Reactome | macitentan [extracellular region]

macitentan [extracellular region]

Stable Identifier

R-ALL-9731352

Type

ChemicalDrug

Compartment

extracellular region

Synonyms

ACT-064992, Opsumit®

Locations in the PathwayBrowser

for Species:

Expand all

Signal Transduction (Bos taurus)

- Signaling by GPCR (Bos taurus)
  - GPCR ligand binding (Bos taurus)
    - Class A/1 (Rhodopsin-like receptors) (Bos taurus)
      - Peptide ligand-binding receptors (Bos taurus)
        
        EDNRA, EDNRB bind non-selective ERAs (Bos taurus)
        
        non-selective ERAs [extracellular region]
        
        macitentan [extracellular region]
        
        EDNRA,EDNRB:non-selective ERAs [plasma membrane] (Bos taurus)
        
        non-selective ERAs [extracellular region]
        
        macitentan [extracellular region]

Signal Transduction (Canis familiaris)

- Signaling by GPCR (Canis familiaris)
  - GPCR ligand binding (Canis familiaris)
    - Class A/1 (Rhodopsin-like receptors) (Canis familiaris)
      - Peptide ligand-binding receptors (Canis familiaris)
        
        EDNRA, EDNRB bind non-selective ERAs (Canis familiaris)
        
        non-selective ERAs [extracellular region]
        
        macitentan [extracellular region]
        
        EDNRA,EDNRB:non-selective ERAs [plasma membrane] (Canis familiaris)
        
        non-selective ERAs [extracellular region]
        
        macitentan [extracellular region]

Signal Transduction (Danio rerio)

- Signaling by GPCR (Danio rerio)
  - GPCR ligand binding (Danio rerio)
    - Class A/1 (Rhodopsin-like receptors) (Danio rerio)
      - Peptide ligand-binding receptors (Danio rerio)
        
        EDNRA, EDNRB bind non-selective ERAs (Danio rerio)
        
        non-selective ERAs [extracellular region]
        
        macitentan [extracellular region]
        
        EDNRA,EDNRB:non-selective ERAs [plasma membrane] (Danio rerio)
        
        non-selective ERAs [extracellular region]
        
        macitentan [extracellular region]

Signal Transduction (Gallus gallus)

- Signaling by GPCR (Gallus gallus)
  - GPCR ligand binding (Gallus gallus)
    - Class A/1 (Rhodopsin-like receptors) (Gallus gallus)
      - Peptide ligand-binding receptors (Gallus gallus)
        
        EDNRA, EDNRB bind non-selective ERAs (Gallus gallus)
        
        non-selective ERAs [extracellular region]
        
        macitentan [extracellular region]
        
        EDNRA,EDNRB:non-selective ERAs [plasma membrane] (Gallus gallus)
        
        non-selective ERAs [extracellular region]
        
        macitentan [extracellular region]

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Peptide ligand-binding receptors (Homo sapiens)
        
        EDNRA, EDNRB bind non-selective ERAs (Homo sapiens)
        
        non-selective ERAs [extracellular region]
        
        macitentan [extracellular region]
        
        EDNRA,EDNRB:non-selective ERAs [plasma membrane] (Homo sapiens)
        
        non-selective ERAs [extracellular region]
        
        macitentan [extracellular region]

Signal Transduction (Mus musculus)

- Signaling by GPCR (Mus musculus)
  - GPCR ligand binding (Mus musculus)
    - Class A/1 (Rhodopsin-like receptors) (Mus musculus)
      - Peptide ligand-binding receptors (Mus musculus)
        
        EDNRA, EDNRB bind non-selective ERAs (Mus musculus)
        
        non-selective ERAs [extracellular region]
        
        macitentan [extracellular region]
        
        EDNRA,EDNRB:non-selective ERAs [plasma membrane] (Mus musculus)
        
        non-selective ERAs [extracellular region]
        
        macitentan [extracellular region]

Signal Transduction (Rattus norvegicus)

- Signaling by GPCR (Rattus norvegicus)
  - GPCR ligand binding (Rattus norvegicus)
    - Class A/1 (Rhodopsin-like receptors) (Rattus norvegicus)
      - Peptide ligand-binding receptors (Rattus norvegicus)
        
        EDNRA, EDNRB bind non-selective ERAs (Rattus norvegicus)
        
        non-selective ERAs [extracellular region]
        
        macitentan [extracellular region]
        
        EDNRA,EDNRB:non-selective ERAs [plasma membrane] (Rattus norvegicus)
        
        non-selective ERAs [extracellular region]
        
        macitentan [extracellular region]

Signal Transduction (Sus scrofa)

- Signaling by GPCR (Sus scrofa)
  - GPCR ligand binding (Sus scrofa)
    - Class A/1 (Rhodopsin-like receptors) (Sus scrofa)
      - Peptide ligand-binding receptors (Sus scrofa)
        
        EDNRA, EDNRB bind non-selective ERAs (Sus scrofa)
        
        non-selective ERAs [extracellular region]
        
        macitentan [extracellular region]
        
        EDNRA,EDNRB:non-selective ERAs [plasma membrane] (Sus scrofa)
        
        non-selective ERAs [extracellular region]
        
        macitentan [extracellular region]

Signal Transduction (Xenopus tropicalis)

- Signaling by GPCR (Xenopus tropicalis)
  - GPCR ligand binding (Xenopus tropicalis)
    - Class A/1 (Rhodopsin-like receptors) (Xenopus tropicalis)
      - Peptide ligand-binding receptors (Xenopus tropicalis)
        
        EDNRA, EDNRB bind non-selective ERAs (Xenopus tropicalis)
        
        non-selective ERAs [extracellular region]
        
        macitentan [extracellular region]
        
        EDNRA,EDNRB:non-selective ERAs [plasma membrane] (Xenopus tropicalis)
        
        non-selective ERAs [extracellular region]
        
        macitentan [extracellular region]

External Reference Information

External Reference

macitentan [Guide to Pharmacology:7352]

Participates

as a member of

non-selective ERAs [extracellular region]

Disease

Name	Identifier	Synonyms
pulmonary hypertension	DOID:6432

Cross References

Mondo

0005149

ChEBI

76607

PubChem Compound

178103924

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