Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
AZD3463 [cytosol]
Stable Identifier
R-ALL-9702329
Type
ChemicalDrug
Compartment
cytosol
Synonyms
AZD-3463, CS-1382, HY-15609, KB-154896
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Canis familiaris
Danio rerio
Gallus gallus
Mus musculus
Rattus norvegicus
Sus scrofa
Xenopus tropicalis
Expand all
Signal Transduction (Bos taurus)
Signaling by Receptor Tyrosine Kinases (Bos taurus)
Signaling by ALK (Bos taurus)
ALK autophosphorylation (Bos taurus)
ALK dimer:ligand:type I ALK binding TKI [plasma membrane] (Bos taurus)
type I ALK-binding TKIs [cytosol]
AZD3463 [cytosol]
Liganded-ALK dimer binds type I ALK-binding TKIs (Bos taurus)
type I ALK-binding TKIs [cytosol]
AZD3463 [cytosol]
ALK dimer:ligand:type I ALK binding TKI [plasma membrane] (Bos taurus)
type I ALK-binding TKIs [cytosol]
AZD3463 [cytosol]
Signal Transduction (Canis familiaris)
Signaling by Receptor Tyrosine Kinases (Canis familiaris)
Signaling by ALK (Canis familiaris)
ALK autophosphorylation (Canis familiaris)
ALK dimer:ligand:type I ALK binding TKI [plasma membrane] (Canis familiaris)
type I ALK-binding TKIs [cytosol]
AZD3463 [cytosol]
Liganded-ALK dimer binds type I ALK-binding TKIs (Canis familiaris)
type I ALK-binding TKIs [cytosol]
AZD3463 [cytosol]
ALK dimer:ligand:type I ALK binding TKI [plasma membrane] (Canis familiaris)
type I ALK-binding TKIs [cytosol]
AZD3463 [cytosol]
Signal Transduction (Danio rerio)
Signaling by Receptor Tyrosine Kinases (Danio rerio)
Signaling by ALK (Danio rerio)
ALK autophosphorylation (Danio rerio)
ALK dimer:ligand:type I ALK binding TKI [plasma membrane] (Danio rerio)
type I ALK-binding TKIs [cytosol]
AZD3463 [cytosol]
Liganded-ALK dimer binds type I ALK-binding TKIs (Danio rerio)
type I ALK-binding TKIs [cytosol]
AZD3463 [cytosol]
ALK dimer:ligand:type I ALK binding TKI [plasma membrane] (Danio rerio)
type I ALK-binding TKIs [cytosol]
AZD3463 [cytosol]
Signal Transduction (Gallus gallus)
Signaling by Receptor Tyrosine Kinases (Gallus gallus)
Signaling by ALK (Gallus gallus)
ALK autophosphorylation (Gallus gallus)
ALK dimer:ligand:type I ALK binding TKI [plasma membrane] (Gallus gallus)
type I ALK-binding TKIs [cytosol]
AZD3463 [cytosol]
Liganded-ALK dimer binds type I ALK-binding TKIs (Gallus gallus)
type I ALK-binding TKIs [cytosol]
AZD3463 [cytosol]
ALK dimer:ligand:type I ALK binding TKI [plasma membrane] (Gallus gallus)
type I ALK-binding TKIs [cytosol]
AZD3463 [cytosol]
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Signaling by ALK in cancer (Homo sapiens)
ALK mutants bind TKIs (Homo sapiens)
ALK mutants bind type I TKIs (Homo sapiens)
type I ALK-binding TKIs [cytosol]
AZD3463 [cytosol]
type I ALK-binding TKIs:type I-sensitive ALK mutants [cytosol] (Homo sapiens)
type I ALK-binding TKIs [cytosol]
AZD3463 [cytosol]
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by ALK (Homo sapiens)
ALK autophosphorylation (Homo sapiens)
type I ALK-binding TKIs [cytosol]
AZD3463 [cytosol]
ALK dimer:ligand:type I ALK binding TKI [plasma membrane] (Homo sapiens)
type I ALK-binding TKIs [cytosol]
AZD3463 [cytosol]
Liganded-ALK dimer binds type I ALK-binding TKIs (Homo sapiens)
type I ALK-binding TKIs [cytosol]
AZD3463 [cytosol]
ALK dimer:ligand:type I ALK binding TKI [plasma membrane] (Homo sapiens)
type I ALK-binding TKIs [cytosol]
AZD3463 [cytosol]
Signal Transduction (Mus musculus)
Signaling by Receptor Tyrosine Kinases (Mus musculus)
Signaling by ALK (Mus musculus)
ALK autophosphorylation (Mus musculus)
ALK dimer:ligand:type I ALK binding TKI [plasma membrane] (Mus musculus)
type I ALK-binding TKIs [cytosol]
AZD3463 [cytosol]
Liganded-ALK dimer binds type I ALK-binding TKIs (Mus musculus)
type I ALK-binding TKIs [cytosol]
AZD3463 [cytosol]
ALK dimer:ligand:type I ALK binding TKI [plasma membrane] (Mus musculus)
type I ALK-binding TKIs [cytosol]
AZD3463 [cytosol]
Signal Transduction (Rattus norvegicus)
Signaling by Receptor Tyrosine Kinases (Rattus norvegicus)
Signaling by ALK (Rattus norvegicus)
ALK autophosphorylation (Rattus norvegicus)
ALK dimer:ligand:type I ALK binding TKI [plasma membrane] (Rattus norvegicus)
type I ALK-binding TKIs [cytosol]
AZD3463 [cytosol]
Liganded-ALK dimer binds type I ALK-binding TKIs (Rattus norvegicus)
type I ALK-binding TKIs [cytosol]
AZD3463 [cytosol]
ALK dimer:ligand:type I ALK binding TKI [plasma membrane] (Rattus norvegicus)
type I ALK-binding TKIs [cytosol]
AZD3463 [cytosol]
Signal Transduction (Sus scrofa)
Signaling by Receptor Tyrosine Kinases (Sus scrofa)
Signaling by ALK (Sus scrofa)
ALK autophosphorylation (Sus scrofa)
ALK dimer:ligand:type I ALK binding TKI [plasma membrane] (Sus scrofa)
type I ALK-binding TKIs [cytosol]
AZD3463 [cytosol]
Liganded-ALK dimer binds type I ALK-binding TKIs (Sus scrofa)
type I ALK-binding TKIs [cytosol]
AZD3463 [cytosol]
ALK dimer:ligand:type I ALK binding TKI [plasma membrane] (Sus scrofa)
type I ALK-binding TKIs [cytosol]
AZD3463 [cytosol]
Signal Transduction (Xenopus tropicalis)
Signaling by Receptor Tyrosine Kinases (Xenopus tropicalis)
Signaling by ALK (Xenopus tropicalis)
ALK autophosphorylation (Xenopus tropicalis)
ALK dimer:ligand:type I ALK binding TKI [plasma membrane] (Xenopus tropicalis)
type I ALK-binding TKIs [cytosol]
AZD3463 [cytosol]
Liganded-ALK dimer binds type I ALK-binding TKIs (Xenopus tropicalis)
type I ALK-binding TKIs [cytosol]
AZD3463 [cytosol]
ALK dimer:ligand:type I ALK binding TKI [plasma membrane] (Xenopus tropicalis)
type I ALK-binding TKIs [cytosol]
AZD3463 [cytosol]
External Reference Information
External Reference
AZD3463 [Guide to Pharmacology:7706]
Participates
as a member of
type I ALK-binding TKIs [cytosol]
Disease
Name
Identifier
Synonyms
cancer
DOID:162
malignant tumor, malignant neoplasm, primary cancer
Cross References
Mondo
0004992
ChEBI
167653
,
167653
PharmacoDB
PDBC02419
© 2026
Reactome
This website requires cookies and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our
Privacy Notice
.
I agree, dismiss this banner
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text
