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vortioxetine [extracellular region]
Stable Identifier
R-ALL-9693466
Type
ChemicalDrug
Compartment
extracellular region
Synonyms
Brintellix®, Lu AA21004, Trintellix®
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Drosophila melanogaster
Gallus gallus
Mus musculus
Plasmodium falciparum
Rattus norvegicus
Sus scrofa
Xenopus tropicalis
Expand all
Neuronal System (Bos taurus)
Transmission across Chemical Synapses (Bos taurus)
Neurotransmitter clearance (Bos taurus)
Serotonin clearance from the synaptic cleft (Bos taurus)
SLC6A4 binds TCAs and SSRIs (Bos taurus)
TCAs, SSRIs [extracellular region]
vortioxetine [extracellular region]
SLC6A4:TCAs and SSRIs [plasma membrane] (Bos taurus)
TCAs, SSRIs [extracellular region]
vortioxetine [extracellular region]
Signal Transduction (Bos taurus)
Signaling by GPCR (Bos taurus)
GPCR ligand binding (Bos taurus)
Class A/1 (Rhodopsin-like receptors) (Bos taurus)
Amine ligand-binding receptors (Bos taurus)
Serotonin receptors (Bos taurus)
HTR1A binds HTR1A agonists (Bos taurus)
HTR1A agonists [extracellular region]
vortioxetine [extracellular region]
HTR1A:HTR1A agonists [plasma membrane] (Bos taurus)
HTR1A agonists [extracellular region]
vortioxetine [extracellular region]
Neuronal System (Caenorhabditis elegans)
Transmission across Chemical Synapses (Caenorhabditis elegans)
Neurotransmitter clearance (Caenorhabditis elegans)
Serotonin clearance from the synaptic cleft (Caenorhabditis elegans)
SLC6A4 binds TCAs and SSRIs (Caenorhabditis elegans)
TCAs, SSRIs [extracellular region]
vortioxetine [extracellular region]
SLC6A4:TCAs and SSRIs [plasma membrane] (Caenorhabditis elegans)
TCAs, SSRIs [extracellular region]
vortioxetine [extracellular region]
Signal Transduction (Caenorhabditis elegans)
Signaling by GPCR (Caenorhabditis elegans)
GPCR ligand binding (Caenorhabditis elegans)
Class A/1 (Rhodopsin-like receptors) (Caenorhabditis elegans)
Amine ligand-binding receptors (Caenorhabditis elegans)
Serotonin receptors (Caenorhabditis elegans)
HTR1A binds HTR1A agonists (Caenorhabditis elegans)
HTR1A agonists [extracellular region]
vortioxetine [extracellular region]
HTR1A:HTR1A agonists [plasma membrane] (Caenorhabditis elegans)
HTR1A agonists [extracellular region]
vortioxetine [extracellular region]
Neuronal System (Canis familiaris)
Transmission across Chemical Synapses (Canis familiaris)
Neurotransmitter clearance (Canis familiaris)
Serotonin clearance from the synaptic cleft (Canis familiaris)
SLC6A4 binds TCAs and SSRIs (Canis familiaris)
TCAs, SSRIs [extracellular region]
vortioxetine [extracellular region]
SLC6A4:TCAs and SSRIs [plasma membrane] (Canis familiaris)
TCAs, SSRIs [extracellular region]
vortioxetine [extracellular region]
Signal Transduction (Canis familiaris)
Signaling by GPCR (Canis familiaris)
GPCR ligand binding (Canis familiaris)
Class A/1 (Rhodopsin-like receptors) (Canis familiaris)
Amine ligand-binding receptors (Canis familiaris)
Serotonin receptors (Canis familiaris)
HTR1A binds HTR1A agonists (Canis familiaris)
HTR1A agonists [extracellular region]
vortioxetine [extracellular region]
HTR1A:HTR1A agonists [plasma membrane] (Canis familiaris)
HTR1A agonists [extracellular region]
vortioxetine [extracellular region]
Neuronal System (Danio rerio)
Transmission across Chemical Synapses (Danio rerio)
Neurotransmitter clearance (Danio rerio)
Serotonin clearance from the synaptic cleft (Danio rerio)
SLC6A4 binds TCAs and SSRIs (Danio rerio)
TCAs, SSRIs [extracellular region]
vortioxetine [extracellular region]
SLC6A4:TCAs and SSRIs [plasma membrane] (Danio rerio)
TCAs, SSRIs [extracellular region]
vortioxetine [extracellular region]
Signal Transduction (Danio rerio)
Signaling by GPCR (Danio rerio)
GPCR ligand binding (Danio rerio)
Class A/1 (Rhodopsin-like receptors) (Danio rerio)
Amine ligand-binding receptors (Danio rerio)
Serotonin receptors (Danio rerio)
HTR1A binds HTR1A agonists (Danio rerio)
HTR1A agonists [extracellular region]
vortioxetine [extracellular region]
HTR1A:HTR1A agonists [plasma membrane] (Danio rerio)
HTR1A agonists [extracellular region]
vortioxetine [extracellular region]
Neuronal System (Drosophila melanogaster)
Transmission across Chemical Synapses (Drosophila melanogaster)
Neurotransmitter clearance (Drosophila melanogaster)
Serotonin clearance from the synaptic cleft (Drosophila melanogaster)
SLC6A4 binds TCAs and SSRIs (Drosophila melanogaster)
TCAs, SSRIs [extracellular region]
vortioxetine [extracellular region]
SLC6A4:TCAs and SSRIs [plasma membrane] (Drosophila melanogaster)
TCAs, SSRIs [extracellular region]
vortioxetine [extracellular region]
Signal Transduction (Drosophila melanogaster)
Signaling by GPCR (Drosophila melanogaster)
GPCR ligand binding (Drosophila melanogaster)
Class A/1 (Rhodopsin-like receptors) (Drosophila melanogaster)
Amine ligand-binding receptors (Drosophila melanogaster)
Serotonin receptors (Drosophila melanogaster)
HTR1A binds HTR1A agonists (Drosophila melanogaster)
HTR1A agonists [extracellular region]
vortioxetine [extracellular region]
HTR1A:HTR1A agonists [plasma membrane] (Drosophila melanogaster)
HTR1A agonists [extracellular region]
vortioxetine [extracellular region]
Neuronal System (Gallus gallus)
Transmission across Chemical Synapses (Gallus gallus)
Neurotransmitter clearance (Gallus gallus)
Serotonin clearance from the synaptic cleft (Gallus gallus)
SLC6A4 binds TCAs and SSRIs (Gallus gallus)
TCAs, SSRIs [extracellular region]
vortioxetine [extracellular region]
SLC6A4:TCAs and SSRIs [plasma membrane] (Gallus gallus)
TCAs, SSRIs [extracellular region]
vortioxetine [extracellular region]
Signal Transduction (Gallus gallus)
Signaling by GPCR (Gallus gallus)
GPCR ligand binding (Gallus gallus)
Class A/1 (Rhodopsin-like receptors) (Gallus gallus)
Amine ligand-binding receptors (Gallus gallus)
Serotonin receptors (Gallus gallus)
HTR1A binds HTR1A agonists (Gallus gallus)
HTR1A agonists [extracellular region]
vortioxetine [extracellular region]
HTR1A:HTR1A agonists [plasma membrane] (Gallus gallus)
HTR1A agonists [extracellular region]
vortioxetine [extracellular region]
Neuronal System (Homo sapiens)
Transmission across Chemical Synapses (Homo sapiens)
Neurotransmitter clearance (Homo sapiens)
Serotonin clearance from the synaptic cleft (Homo sapiens)
SLC6A4 binds TCAs and SSRIs (Homo sapiens)
TCAs, SSRIs [extracellular region]
vortioxetine [extracellular region]
SLC6A4:TCAs and SSRIs [plasma membrane] (Homo sapiens)
TCAs, SSRIs [extracellular region]
vortioxetine [extracellular region]
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Amine ligand-binding receptors (Homo sapiens)
Serotonin receptors (Homo sapiens)
HTR1A binds HTR1A agonists (Homo sapiens)
HTR1A agonists [extracellular region]
vortioxetine [extracellular region]
HTR1A:HTR1A agonists [plasma membrane] (Homo sapiens)
HTR1A agonists [extracellular region]
vortioxetine [extracellular region]
Neuronal System (Mus musculus)
Transmission across Chemical Synapses (Mus musculus)
Neurotransmitter clearance (Mus musculus)
Serotonin clearance from the synaptic cleft (Mus musculus)
SLC6A4 binds TCAs and SSRIs (Mus musculus)
TCAs, SSRIs [extracellular region]
vortioxetine [extracellular region]
SLC6A4:TCAs and SSRIs [plasma membrane] (Mus musculus)
TCAs, SSRIs [extracellular region]
vortioxetine [extracellular region]
Signal Transduction (Mus musculus)
Signaling by GPCR (Mus musculus)
GPCR ligand binding (Mus musculus)
Class A/1 (Rhodopsin-like receptors) (Mus musculus)
Amine ligand-binding receptors (Mus musculus)
Serotonin receptors (Mus musculus)
HTR1A binds HTR1A agonists (Mus musculus)
HTR1A agonists [extracellular region]
vortioxetine [extracellular region]
HTR1A:HTR1A agonists [plasma membrane] (Mus musculus)
HTR1A agonists [extracellular region]
vortioxetine [extracellular region]
Neuronal System (Plasmodium falciparum)
Transmission across Chemical Synapses (Plasmodium falciparum)
Neurotransmitter clearance (Plasmodium falciparum)
Serotonin clearance from the synaptic cleft (Plasmodium falciparum)
SLC6A4 binds TCAs and SSRIs (Plasmodium falciparum)
TCAs, SSRIs [extracellular region]
vortioxetine [extracellular region]
SLC6A4:TCAs and SSRIs [plasma membrane] (Plasmodium falciparum)
TCAs, SSRIs [extracellular region]
vortioxetine [extracellular region]
Neuronal System (Rattus norvegicus)
Transmission across Chemical Synapses (Rattus norvegicus)
Neurotransmitter clearance (Rattus norvegicus)
Serotonin clearance from the synaptic cleft (Rattus norvegicus)
SLC6A4 binds TCAs and SSRIs (Rattus norvegicus)
TCAs, SSRIs [extracellular region]
vortioxetine [extracellular region]
SLC6A4:TCAs and SSRIs [plasma membrane] (Rattus norvegicus)
TCAs, SSRIs [extracellular region]
vortioxetine [extracellular region]
Signal Transduction (Rattus norvegicus)
Signaling by GPCR (Rattus norvegicus)
GPCR ligand binding (Rattus norvegicus)
Class A/1 (Rhodopsin-like receptors) (Rattus norvegicus)
Amine ligand-binding receptors (Rattus norvegicus)
Serotonin receptors (Rattus norvegicus)
HTR1A binds HTR1A agonists (Rattus norvegicus)
HTR1A agonists [extracellular region]
vortioxetine [extracellular region]
HTR1A:HTR1A agonists [plasma membrane] (Rattus norvegicus)
HTR1A agonists [extracellular region]
vortioxetine [extracellular region]
Neuronal System (Sus scrofa)
Transmission across Chemical Synapses (Sus scrofa)
Neurotransmitter clearance (Sus scrofa)
Serotonin clearance from the synaptic cleft (Sus scrofa)
SLC6A4 binds TCAs and SSRIs (Sus scrofa)
TCAs, SSRIs [extracellular region]
vortioxetine [extracellular region]
SLC6A4:TCAs and SSRIs [plasma membrane] (Sus scrofa)
TCAs, SSRIs [extracellular region]
vortioxetine [extracellular region]
Neuronal System (Xenopus tropicalis)
Transmission across Chemical Synapses (Xenopus tropicalis)
Neurotransmitter clearance (Xenopus tropicalis)
Serotonin clearance from the synaptic cleft (Xenopus tropicalis)
SLC6A4 binds TCAs and SSRIs (Xenopus tropicalis)
TCAs, SSRIs [extracellular region]
vortioxetine [extracellular region]
SLC6A4:TCAs and SSRIs [plasma membrane] (Xenopus tropicalis)
TCAs, SSRIs [extracellular region]
vortioxetine [extracellular region]
External Reference Information
External Reference
vortioxetine [Guide to Pharmacology:7351]
Participates
as a member of
TCAs, SSRIs [extracellular region]
HTR1A agonists [extracellular region]
Disease
Name
Identifier
Synonyms
major depressive disorder
DOID:1470
single major depressive episode, recurrent major depression
Cross References
Mondo
0002009
ChEBI
76016
Pharos - Ligands
61XVHP11WT9M
PubChem Compound
178103923
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