Reactome | flibanserin [extracellular region]

flibanserin [extracellular region]

Stable Identifier

R-ALL-9693462

Type

ChemicalDrug

Compartment

extracellular region

Synonyms

Addyi®, BIMT-17, Girosa® (proposed trade name)

Locations in the PathwayBrowser

for Species:

Expand all

Signal Transduction (Bos taurus)

- Signaling by GPCR (Bos taurus)
  - GPCR ligand binding (Bos taurus)
    - Class A/1 (Rhodopsin-like receptors) (Bos taurus)
      - Amine ligand-binding receptors (Bos taurus)
        
        Serotonin receptors (Bos taurus)
        
        HTR1A binds HTR1A agonists (Bos taurus)
        
        HTR1A agonists [extracellular region]
        
        flibanserin [extracellular region]
        
        HTR1A:HTR1A agonists [plasma membrane] (Bos taurus)
        
        HTR1A agonists [extracellular region]
        
        flibanserin [extracellular region]

Signal Transduction (Caenorhabditis elegans)

- Signaling by GPCR (Caenorhabditis elegans)
  - GPCR ligand binding (Caenorhabditis elegans)
    - Class A/1 (Rhodopsin-like receptors) (Caenorhabditis elegans)
      - Amine ligand-binding receptors (Caenorhabditis elegans)
        
        Serotonin receptors (Caenorhabditis elegans)
        
        HTR1A binds HTR1A agonists (Caenorhabditis elegans)
        
        HTR1A agonists [extracellular region]
        
        flibanserin [extracellular region]
        
        HTR1A:HTR1A agonists [plasma membrane] (Caenorhabditis elegans)
        
        HTR1A agonists [extracellular region]
        
        flibanserin [extracellular region]

Signal Transduction (Canis familiaris)

- Signaling by GPCR (Canis familiaris)
  - GPCR ligand binding (Canis familiaris)
    - Class A/1 (Rhodopsin-like receptors) (Canis familiaris)
      - Amine ligand-binding receptors (Canis familiaris)
        
        Serotonin receptors (Canis familiaris)
        
        HTR1A binds HTR1A agonists (Canis familiaris)
        
        HTR1A agonists [extracellular region]
        
        flibanserin [extracellular region]
        
        HTR1A:HTR1A agonists [plasma membrane] (Canis familiaris)
        
        HTR1A agonists [extracellular region]
        
        flibanserin [extracellular region]

Signal Transduction (Danio rerio)

- Signaling by GPCR (Danio rerio)
  - GPCR ligand binding (Danio rerio)
    - Class A/1 (Rhodopsin-like receptors) (Danio rerio)
      - Amine ligand-binding receptors (Danio rerio)
        
        Serotonin receptors (Danio rerio)
        
        HTR1A binds HTR1A agonists (Danio rerio)
        
        HTR1A agonists [extracellular region]
        
        flibanserin [extracellular region]
        
        HTR1A:HTR1A agonists [plasma membrane] (Danio rerio)
        
        HTR1A agonists [extracellular region]
        
        flibanserin [extracellular region]

Signal Transduction (Drosophila melanogaster)

- Signaling by GPCR (Drosophila melanogaster)
  - GPCR ligand binding (Drosophila melanogaster)
    - Class A/1 (Rhodopsin-like receptors) (Drosophila melanogaster)
      - Amine ligand-binding receptors (Drosophila melanogaster)
        
        Serotonin receptors (Drosophila melanogaster)
        
        HTR1A binds HTR1A agonists (Drosophila melanogaster)
        
        HTR1A agonists [extracellular region]
        
        flibanserin [extracellular region]
        
        HTR1A:HTR1A agonists [plasma membrane] (Drosophila melanogaster)
        
        HTR1A agonists [extracellular region]
        
        flibanserin [extracellular region]

Signal Transduction (Gallus gallus)

- Signaling by GPCR (Gallus gallus)
  - GPCR ligand binding (Gallus gallus)
    - Class A/1 (Rhodopsin-like receptors) (Gallus gallus)
      - Amine ligand-binding receptors (Gallus gallus)
        
        Serotonin receptors (Gallus gallus)
        
        HTR1A binds HTR1A agonists (Gallus gallus)
        
        HTR1A agonists [extracellular region]
        
        flibanserin [extracellular region]
        
        HTR1A:HTR1A agonists [plasma membrane] (Gallus gallus)
        
        HTR1A agonists [extracellular region]
        
        flibanserin [extracellular region]

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Amine ligand-binding receptors (Homo sapiens)
        
        Serotonin receptors (Homo sapiens)
        
        HTR1A binds HTR1A agonists (Homo sapiens)
        
        HTR1A agonists [extracellular region]
        
        flibanserin [extracellular region]
        
        HTR1A:HTR1A agonists [plasma membrane] (Homo sapiens)
        
        HTR1A agonists [extracellular region]
        
        flibanserin [extracellular region]

Signal Transduction (Mus musculus)

- Signaling by GPCR (Mus musculus)
  - GPCR ligand binding (Mus musculus)
    - Class A/1 (Rhodopsin-like receptors) (Mus musculus)
      - Amine ligand-binding receptors (Mus musculus)
        
        Serotonin receptors (Mus musculus)
        
        HTR1A binds HTR1A agonists (Mus musculus)
        
        HTR1A agonists [extracellular region]
        
        flibanserin [extracellular region]
        
        HTR1A:HTR1A agonists [plasma membrane] (Mus musculus)
        
        HTR1A agonists [extracellular region]
        
        flibanserin [extracellular region]

Signal Transduction (Rattus norvegicus)

- Signaling by GPCR (Rattus norvegicus)
  - GPCR ligand binding (Rattus norvegicus)
    - Class A/1 (Rhodopsin-like receptors) (Rattus norvegicus)
      - Amine ligand-binding receptors (Rattus norvegicus)
        
        Serotonin receptors (Rattus norvegicus)
        
        HTR1A binds HTR1A agonists (Rattus norvegicus)
        
        HTR1A agonists [extracellular region]
        
        flibanserin [extracellular region]
        
        HTR1A:HTR1A agonists [plasma membrane] (Rattus norvegicus)
        
        HTR1A agonists [extracellular region]
        
        flibanserin [extracellular region]

External Reference Information

External Reference

flibanserin [Guide to Pharmacology:8182]

Participates

as a member of

HTR1A agonists [extracellular region]

Disease

Name	Identifier	Synonyms
hypoactive sexual desire disorder	DOID:13868	Lack or loss of sexual desire

Cross References

Mondo

0001821

ChEBI

90865

Pharos - Ligands

GR23QZKJ5F95

PubChem Compound

249565862

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