Reactome | azelastine [extracellular region]

azelastine [extracellular region]

Stable Identifier

R-ALL-9692551

Type

ChemicalDrug

Compartment

extracellular region

Locations in the PathwayBrowser

for Species:

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Signal Transduction (Canis familiaris)

- Signaling by GPCR (Canis familiaris)
  - GPCR ligand binding (Canis familiaris)
    - Class A/1 (Rhodopsin-like receptors) (Canis familiaris)
      - Amine ligand-binding receptors (Canis familiaris)
        
        Histamine receptors (Canis familiaris)
        
        HRH1 binds HRH1 inverse agonists (Canis familiaris)
        
        HRH1 inverse agonists [extracellular region]
        
        azelastine [extracellular region]
        
        HRH1:HRH1 inverse agonists [plasma membrane] (Canis familiaris)
        
        HRH1 inverse agonists [extracellular region]
        
        azelastine [extracellular region]

Signal Transduction (Gallus gallus)

- Signaling by GPCR (Gallus gallus)
  - GPCR ligand binding (Gallus gallus)
    - Class A/1 (Rhodopsin-like receptors) (Gallus gallus)
      - Amine ligand-binding receptors (Gallus gallus)
        
        Histamine receptors (Gallus gallus)
        
        HRH1 binds HRH1 inverse agonists (Gallus gallus)
        
        HRH1 inverse agonists [extracellular region]
        
        azelastine [extracellular region]
        
        HRH1:HRH1 inverse agonists [plasma membrane] (Gallus gallus)
        
        HRH1 inverse agonists [extracellular region]
        
        azelastine [extracellular region]

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - SARS-CoV Infections (Homo sapiens)
      - SARS-CoV-1 Infection (Homo sapiens)
        
        Attachment and Entry (Homo sapiens)
        
        glycosylated-ACE2 binds ACE2 inhibitors (Homo sapiens)
        
        ACE2 inhibitors [extracellular region]
        
        azelastine [extracellular region]
        
        glycosylated-ACE2:ACE2 inhibitors [plasma membrane] (Homo sapiens)
        
        ACE2 inhibitors [extracellular region]
        
        azelastine [extracellular region]

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Amine ligand-binding receptors (Homo sapiens)
        
        Histamine receptors (Homo sapiens)
        
        HRH1 binds HRH1 inverse agonists (Homo sapiens)
        
        HRH1 inverse agonists [extracellular region]
        
        azelastine [extracellular region]
        
        HRH1:HRH1 inverse agonists [plasma membrane] (Homo sapiens)
        
        HRH1 inverse agonists [extracellular region]
        
        azelastine [extracellular region]

Signal Transduction (Mus musculus)

- Signaling by GPCR (Mus musculus)
  - GPCR ligand binding (Mus musculus)
    - Class A/1 (Rhodopsin-like receptors) (Mus musculus)
      - Amine ligand-binding receptors (Mus musculus)
        
        Histamine receptors (Mus musculus)
        
        HRH1 binds HRH1 inverse agonists (Mus musculus)
        
        HRH1 inverse agonists [extracellular region]
        
        azelastine [extracellular region]
        
        HRH1:HRH1 inverse agonists [plasma membrane] (Mus musculus)
        
        HRH1 inverse agonists [extracellular region]
        
        azelastine [extracellular region]

Signal Transduction (Rattus norvegicus)

- Signaling by GPCR (Rattus norvegicus)
  - GPCR ligand binding (Rattus norvegicus)
    - Class A/1 (Rhodopsin-like receptors) (Rattus norvegicus)
      - Amine ligand-binding receptors (Rattus norvegicus)
        
        Histamine receptors (Rattus norvegicus)
        
        HRH1 binds HRH1 inverse agonists (Rattus norvegicus)
        
        HRH1 inverse agonists [extracellular region]
        
        azelastine [extracellular region]
        
        HRH1:HRH1 inverse agonists [plasma membrane] (Rattus norvegicus)
        
        HRH1 inverse agonists [extracellular region]
        
        azelastine [extracellular region]

Signal Transduction (Sus scrofa)

- Signaling by GPCR (Sus scrofa)
  - GPCR ligand binding (Sus scrofa)
    - Class A/1 (Rhodopsin-like receptors) (Sus scrofa)
      - Amine ligand-binding receptors (Sus scrofa)
        
        Histamine receptors (Sus scrofa)
        
        HRH1 binds HRH1 inverse agonists (Sus scrofa)
        
        HRH1 inverse agonists [extracellular region]
        
        azelastine [extracellular region]
        
        HRH1:HRH1 inverse agonists [plasma membrane] (Sus scrofa)
        
        HRH1 inverse agonists [extracellular region]
        
        azelastine [extracellular region]

Signal Transduction (Xenopus tropicalis)

- Signaling by GPCR (Xenopus tropicalis)
  - GPCR ligand binding (Xenopus tropicalis)
    - Class A/1 (Rhodopsin-like receptors) (Xenopus tropicalis)
      - Amine ligand-binding receptors (Xenopus tropicalis)
        
        Histamine receptors (Xenopus tropicalis)
        
        HRH1 binds HRH1 inverse agonists (Xenopus tropicalis)
        
        HRH1 inverse agonists [extracellular region]
        
        azelastine [extracellular region]
        
        HRH1:HRH1 inverse agonists [plasma membrane] (Xenopus tropicalis)
        
        HRH1 inverse agonists [extracellular region]
        
        azelastine [extracellular region]

External Reference Information

External Reference

azelastine [Guide to Pharmacology:7121]

Participates

as a candidate of

ACE2 inhibitors [extracellular region]

as a member of

HRH1 inverse agonists [extracellular region]

Disease

Name	Identifier	Synonyms
allergic rhinitis	DOID:4481	Non-seasonal allergic rhinitis, seasonal allergic rhinitis, atopic rhinitis, hay fever, Perenial allergic rhinitis, pollenosis
allergic conjunctivitis	DOID:11204

Cross References

Mondo

0005642

ChEBI

2950

Pharos - Ligands

VKY49BVV56A6

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