Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
thioguanine [cytosol]
Stable Identifier
R-ALL-9679095
Type
ChemicalDrug
Compartment
cytosol
Synonyms
6-mercaptoguanine, 6-thioguanine, Lanvis®, Tabloid®
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Dictyostelium discoideum
Drosophila melanogaster
Gallus gallus
Mus musculus
Plasmodium falciparum
Rattus norvegicus
Saccharomyces cerevisiae
Schizosaccharomyces pombe
Sus scrofa
Xenopus tropicalis
Expand all
Metabolism (Bos taurus)
Metabolism of nucleotides (Bos taurus)
Nucleotide biosynthesis (Bos taurus)
Purine ribonucleoside monophosphate biosynthesis (Bos taurus)
IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Bos taurus)
IMPDH tetramers:IMPDH inhibitors [cytosol] (Bos taurus)
IMPDH inhibitors [cytosol]
thioguanine [cytosol]
IMPDH tetramers bind IMPDH inhibitors (Bos taurus)
IMPDH inhibitors [cytosol]
thioguanine [cytosol]
IMPDH tetramers:IMPDH inhibitors [cytosol] (Bos taurus)
IMPDH inhibitors [cytosol]
thioguanine [cytosol]
Metabolism (Caenorhabditis elegans)
Metabolism of nucleotides (Caenorhabditis elegans)
Nucleotide biosynthesis (Caenorhabditis elegans)
Purine ribonucleoside monophosphate biosynthesis (Caenorhabditis elegans)
IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Caenorhabditis elegans)
IMPDH tetramers:IMPDH inhibitors [cytosol] (Caenorhabditis elegans)
IMPDH inhibitors [cytosol]
thioguanine [cytosol]
IMPDH tetramers bind IMPDH inhibitors (Caenorhabditis elegans)
IMPDH inhibitors [cytosol]
thioguanine [cytosol]
IMPDH tetramers:IMPDH inhibitors [cytosol] (Caenorhabditis elegans)
IMPDH inhibitors [cytosol]
thioguanine [cytosol]
Metabolism (Canis familiaris)
Metabolism of nucleotides (Canis familiaris)
Nucleotide biosynthesis (Canis familiaris)
Purine ribonucleoside monophosphate biosynthesis (Canis familiaris)
IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Canis familiaris)
IMPDH tetramers:IMPDH inhibitors [cytosol] (Canis familiaris)
IMPDH inhibitors [cytosol]
thioguanine [cytosol]
IMPDH tetramers bind IMPDH inhibitors (Canis familiaris)
IMPDH inhibitors [cytosol]
thioguanine [cytosol]
IMPDH tetramers:IMPDH inhibitors [cytosol] (Canis familiaris)
IMPDH inhibitors [cytosol]
thioguanine [cytosol]
Metabolism (Danio rerio)
Metabolism of nucleotides (Danio rerio)
Nucleotide biosynthesis (Danio rerio)
Purine ribonucleoside monophosphate biosynthesis (Danio rerio)
IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Danio rerio)
IMPDH tetramers:IMPDH inhibitors [cytosol] (Danio rerio)
IMPDH inhibitors [cytosol]
thioguanine [cytosol]
IMPDH tetramers bind IMPDH inhibitors (Danio rerio)
IMPDH inhibitors [cytosol]
thioguanine [cytosol]
IMPDH tetramers:IMPDH inhibitors [cytosol] (Danio rerio)
IMPDH inhibitors [cytosol]
thioguanine [cytosol]
Metabolism (Dictyostelium discoideum)
Metabolism of nucleotides (Dictyostelium discoideum)
Nucleotide biosynthesis (Dictyostelium discoideum)
Purine ribonucleoside monophosphate biosynthesis (Dictyostelium discoideum)
IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Dictyostelium discoideum)
IMPDH tetramers:IMPDH inhibitors [cytosol] (Dictyostelium discoideum)
IMPDH inhibitors [cytosol]
thioguanine [cytosol]
IMPDH tetramers bind IMPDH inhibitors (Dictyostelium discoideum)
IMPDH inhibitors [cytosol]
thioguanine [cytosol]
IMPDH tetramers:IMPDH inhibitors [cytosol] (Dictyostelium discoideum)
IMPDH inhibitors [cytosol]
thioguanine [cytosol]
Metabolism (Drosophila melanogaster)
Metabolism of nucleotides (Drosophila melanogaster)
Nucleotide biosynthesis (Drosophila melanogaster)
Purine ribonucleoside monophosphate biosynthesis (Drosophila melanogaster)
IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Drosophila melanogaster)
IMPDH tetramers:IMPDH inhibitors [cytosol] (Drosophila melanogaster)
IMPDH inhibitors [cytosol]
thioguanine [cytosol]
IMPDH tetramers bind IMPDH inhibitors (Drosophila melanogaster)
IMPDH inhibitors [cytosol]
thioguanine [cytosol]
IMPDH tetramers:IMPDH inhibitors [cytosol] (Drosophila melanogaster)
IMPDH inhibitors [cytosol]
thioguanine [cytosol]
Metabolism (Gallus gallus)
Metabolism of nucleotides (Gallus gallus)
Nucleotide biosynthesis (Gallus gallus)
Purine ribonucleoside monophosphate biosynthesis (Gallus gallus)
IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Gallus gallus)
IMPDH tetramers:IMPDH inhibitors [cytosol] (Gallus gallus)
IMPDH inhibitors [cytosol]
thioguanine [cytosol]
IMPDH tetramers bind IMPDH inhibitors (Gallus gallus)
IMPDH inhibitors [cytosol]
thioguanine [cytosol]
IMPDH tetramers:IMPDH inhibitors [cytosol] (Gallus gallus)
IMPDH inhibitors [cytosol]
thioguanine [cytosol]
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
Potential therapeutics for SARS (Homo sapiens)
IMPDH tetramers bind IMPDH inhibitors (Homo sapiens)
IMPDH inhibitors [cytosol]
thioguanine [cytosol]
IMPDH tetramers:IMPDH inhibitors [cytosol] (Homo sapiens)
IMPDH inhibitors [cytosol]
thioguanine [cytosol]
SARS-CoV-2 Infection (Homo sapiens)
Early SARS-CoV-2 Infection Events (Homo sapiens)
Translation of Replicase and Assembly of the Replication Transcription Complex (Homo sapiens)
Maturation of replicase proteins (Homo sapiens)
nsp3 binds to PLpro inhibitors (Homo sapiens)
PLpro inhibitors [cytosol]
thioguanine [cytosol]
nsp3:PLpro inhibitors [cytosol] (Severe acute respiratory syndrome coronavirus 2)
PLpro inhibitors [cytosol]
thioguanine [cytosol]
Metabolism (Homo sapiens)
Metabolism of nucleotides (Homo sapiens)
Nucleotide biosynthesis (Homo sapiens)
Purine ribonucleoside monophosphate biosynthesis (Homo sapiens)
IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Homo sapiens)
IMPDH tetramers:IMPDH inhibitors [cytosol] (Homo sapiens)
IMPDH inhibitors [cytosol]
thioguanine [cytosol]
IMPDH tetramers bind IMPDH inhibitors (Homo sapiens)
IMPDH inhibitors [cytosol]
thioguanine [cytosol]
IMPDH tetramers:IMPDH inhibitors [cytosol] (Homo sapiens)
IMPDH inhibitors [cytosol]
thioguanine [cytosol]
Metabolism (Mus musculus)
Metabolism of nucleotides (Mus musculus)
Nucleotide biosynthesis (Mus musculus)
Purine ribonucleoside monophosphate biosynthesis (Mus musculus)
IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Mus musculus)
IMPDH tetramers:IMPDH inhibitors [cytosol] (Mus musculus)
IMPDH inhibitors [cytosol]
thioguanine [cytosol]
IMPDH tetramers bind IMPDH inhibitors (Mus musculus)
IMPDH inhibitors [cytosol]
thioguanine [cytosol]
IMPDH tetramers:IMPDH inhibitors [cytosol] (Mus musculus)
IMPDH inhibitors [cytosol]
thioguanine [cytosol]
Metabolism (Plasmodium falciparum)
Metabolism of nucleotides (Plasmodium falciparum)
Nucleotide biosynthesis (Plasmodium falciparum)
Purine ribonucleoside monophosphate biosynthesis (Plasmodium falciparum)
IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Plasmodium falciparum)
IMPDH tetramers:IMPDH inhibitors [cytosol] (Plasmodium falciparum)
IMPDH inhibitors [cytosol]
thioguanine [cytosol]
IMPDH tetramers bind IMPDH inhibitors (Plasmodium falciparum)
IMPDH inhibitors [cytosol]
thioguanine [cytosol]
IMPDH tetramers:IMPDH inhibitors [cytosol] (Plasmodium falciparum)
IMPDH inhibitors [cytosol]
thioguanine [cytosol]
Metabolism (Rattus norvegicus)
Metabolism of nucleotides (Rattus norvegicus)
Nucleotide biosynthesis (Rattus norvegicus)
Purine ribonucleoside monophosphate biosynthesis (Rattus norvegicus)
IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Rattus norvegicus)
IMPDH tetramers:IMPDH inhibitors [cytosol] (Rattus norvegicus)
IMPDH inhibitors [cytosol]
thioguanine [cytosol]
IMPDH tetramers bind IMPDH inhibitors (Rattus norvegicus)
IMPDH inhibitors [cytosol]
thioguanine [cytosol]
IMPDH tetramers:IMPDH inhibitors [cytosol] (Rattus norvegicus)
IMPDH inhibitors [cytosol]
thioguanine [cytosol]
Metabolism (Saccharomyces cerevisiae)
Metabolism of nucleotides (Saccharomyces cerevisiae)
Nucleotide biosynthesis (Saccharomyces cerevisiae)
Purine ribonucleoside monophosphate biosynthesis (Saccharomyces cerevisiae)
IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Saccharomyces cerevisiae)
IMPDH tetramers:IMPDH inhibitors [cytosol] (Saccharomyces cerevisiae)
IMPDH inhibitors [cytosol]
thioguanine [cytosol]
IMPDH tetramers bind IMPDH inhibitors (Saccharomyces cerevisiae)
IMPDH inhibitors [cytosol]
thioguanine [cytosol]
IMPDH tetramers:IMPDH inhibitors [cytosol] (Saccharomyces cerevisiae)
IMPDH inhibitors [cytosol]
thioguanine [cytosol]
Metabolism (Schizosaccharomyces pombe)
Metabolism of nucleotides (Schizosaccharomyces pombe)
Nucleotide biosynthesis (Schizosaccharomyces pombe)
Purine ribonucleoside monophosphate biosynthesis (Schizosaccharomyces pombe)
IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Schizosaccharomyces pombe)
IMPDH tetramers:IMPDH inhibitors [cytosol] (Schizosaccharomyces pombe)
IMPDH inhibitors [cytosol]
thioguanine [cytosol]
IMPDH tetramers bind IMPDH inhibitors (Schizosaccharomyces pombe)
IMPDH inhibitors [cytosol]
thioguanine [cytosol]
IMPDH tetramers:IMPDH inhibitors [cytosol] (Schizosaccharomyces pombe)
IMPDH inhibitors [cytosol]
thioguanine [cytosol]
Metabolism (Sus scrofa)
Metabolism of nucleotides (Sus scrofa)
Nucleotide biosynthesis (Sus scrofa)
Purine ribonucleoside monophosphate biosynthesis (Sus scrofa)
IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Sus scrofa)
IMPDH tetramers:IMPDH inhibitors [cytosol] (Sus scrofa)
IMPDH inhibitors [cytosol]
thioguanine [cytosol]
IMPDH tetramers bind IMPDH inhibitors (Sus scrofa)
IMPDH inhibitors [cytosol]
thioguanine [cytosol]
IMPDH tetramers:IMPDH inhibitors [cytosol] (Sus scrofa)
IMPDH inhibitors [cytosol]
thioguanine [cytosol]
Metabolism (Xenopus tropicalis)
Metabolism of nucleotides (Xenopus tropicalis)
Nucleotide biosynthesis (Xenopus tropicalis)
Purine ribonucleoside monophosphate biosynthesis (Xenopus tropicalis)
IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2] (Xenopus tropicalis)
IMPDH tetramers:IMPDH inhibitors [cytosol] (Xenopus tropicalis)
IMPDH inhibitors [cytosol]
thioguanine [cytosol]
IMPDH tetramers bind IMPDH inhibitors (Xenopus tropicalis)
IMPDH inhibitors [cytosol]
thioguanine [cytosol]
IMPDH tetramers:IMPDH inhibitors [cytosol] (Xenopus tropicalis)
IMPDH inhibitors [cytosol]
thioguanine [cytosol]
External Reference Information
External Reference
thioguanine [Guide to Pharmacology:6845]
Participates
as a member of
PLpro inhibitors [cytosol]
IMPDH inhibitors [cytosol]
Disease
Name
Identifier
Synonyms
myeloid leukemia
DOID:8692
Non-Lymphocytic Leukemia, myeloid granulocytic leukaemia, myeloid leukaemia, leukaemia myelogenous, leukemia myelogenous, myeloid granulocytic leukemia
Cross References
Mondo
0004643
ChEBI
9555
PubChem Compound
178103451
PharmacoDB
PDBC00163
© 2026
Reactome
This website requires cookies and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our
Privacy Notice
.
I agree, dismiss this banner
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text