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pexidartinib [cytosol]
Stable Identifier
R-ALL-9677649
Type
ChemicalDrug
Compartment
cytosol
Synonyms
PLX3397, PLX-3397, Turalio®
Icon
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Canis familiaris
Mus musculus
Rattus norvegicus
Sus scrofa
Expand all
Immune System (Bos taurus)
Cytokine Signaling in Immune system (Bos taurus)
FLT3 Signaling (Bos taurus)
FLT3LG dimer:FLT3 dimer autophosphorylates (Bos taurus)
FLT3:FLT3-binding type II TKIs [plasma membrane] (Bos taurus)
type II FLT3-binding TKIs [cytosol]
pexidartinib [cytosol]
Immune System (Canis familiaris)
Cytokine Signaling in Immune system (Canis familiaris)
FLT3 Signaling (Canis familiaris)
FLT3LG dimer:FLT3 dimer autophosphorylates (Canis familiaris)
FLT3:FLT3-binding type II TKIs [plasma membrane] (Canis familiaris)
type II FLT3-binding TKIs [cytosol]
pexidartinib [cytosol]
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
FLT3 signaling in disease (Homo sapiens)
Drug resistance of FLT3 mutants (Homo sapiens)
pexidartinib-resistant FLT3 mutants (Homo sapiens)
pexidartinib-resistant FLT3 mutants don't bind pexidartinib (Homo sapiens)
pexidartinib [cytosol]
FLT3 mutants bind TKIs (Homo sapiens)
FLT mutants bind type II TKIs (Homo sapiens)
type II FLT3-binding TKIs [cytosol]
pexidartinib [cytosol]
type II TKI-sensitive FLT3 mutants:type II TKIs [plasma membrane] (Homo sapiens)
type II FLT3-binding TKIs [cytosol]
pexidartinib [cytosol]
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
FLT3 Signaling (Homo sapiens)
FLT3 binds type II TKI (Homo sapiens)
type II FLT3-binding TKIs [cytosol]
pexidartinib [cytosol]
FLT3:FLT3-binding type II TKIs [plasma membrane] (Homo sapiens)
type II FLT3-binding TKIs [cytosol]
pexidartinib [cytosol]
FLT3LG dimer:FLT3 dimer autophosphorylates (Homo sapiens)
type II FLT3-binding TKIs [cytosol]
pexidartinib [cytosol]
FLT3:FLT3-binding type II TKIs [plasma membrane] (Homo sapiens)
type II FLT3-binding TKIs [cytosol]
pexidartinib [cytosol]
Immune System (Mus musculus)
Cytokine Signaling in Immune system (Mus musculus)
FLT3 Signaling (Mus musculus)
FLT3LG dimer:FLT3 dimer autophosphorylates (Mus musculus)
FLT3:FLT3-binding type II TKIs [plasma membrane] (Mus musculus)
type II FLT3-binding TKIs [cytosol]
pexidartinib [cytosol]
Immune System (Rattus norvegicus)
Cytokine Signaling in Immune system (Rattus norvegicus)
FLT3 Signaling (Rattus norvegicus)
FLT3LG dimer:FLT3 dimer autophosphorylates (Rattus norvegicus)
FLT3:FLT3-binding type II TKIs [plasma membrane] (Rattus norvegicus)
type II FLT3-binding TKIs [cytosol]
pexidartinib [cytosol]
Immune System (Sus scrofa)
Cytokine Signaling in Immune system (Sus scrofa)
FLT3 Signaling (Sus scrofa)
FLT3LG dimer:FLT3 dimer autophosphorylates (Sus scrofa)
FLT3:FLT3-binding type II TKIs [plasma membrane] (Sus scrofa)
type II FLT3-binding TKIs [cytosol]
pexidartinib [cytosol]
External Reference Information
External Reference
pexidartinib [Guide to Pharmacology:8710]
Participates
as an input of
pexidartinib-resistant FLT3 mutants don't bind pexidartinib (Homo sapiens)
as a member of
type II FLT3-binding TKIs [cytosol]
Disease
Name
Identifier
Synonyms
cancer
DOID:162
malignant tumor, malignant neoplasm, primary cancer
Cross References
ChEBI
145373
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