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crenolanib [cytosol]
Stable Identifier
R-ALL-9674072
Type
ChemicalDrug
Compartment
cytosol
Synonyms
ARO-002, CP 868596, CP-868596, CP-868,596
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Drosophila melanogaster
Gallus gallus
Mus musculus
Rattus norvegicus
Sus scrofa
Xenopus tropicalis
Expand all
Immune System (Bos taurus)
Cytokine Signaling in Immune system (Bos taurus)
FLT3 Signaling (Bos taurus)
FLT3LG dimer:FLT3 dimer autophosphorylates (Bos taurus)
FLT3LG dimer:FLT3:FLT3-binding type I TKIs [plasma membrane] (Bos taurus)
type I FLT3-binding TKIs [cytosol]
crenolanib [cytosol]
Signal Transduction (Bos taurus)
Signaling by Receptor Tyrosine Kinases (Bos taurus)
Signaling by PDGF (Bos taurus)
Autophosphorylation of PDGF alpha receptors (Bos taurus)
PDGFR:type I PDGFR-binding TKIs [plasma membrane] (Bos taurus)
type I PDGFR-binding tyrosine kinase inhibitors [cytosol]
crenolanib [cytosol]
PDGFRs bind type I TKI (Bos taurus)
type I PDGFR-binding tyrosine kinase inhibitors [cytosol]
crenolanib [cytosol]
PDGFR:type I PDGFR-binding TKIs [plasma membrane] (Bos taurus)
type I PDGFR-binding tyrosine kinase inhibitors [cytosol]
crenolanib [cytosol]
Signal Transduction (Caenorhabditis elegans)
Signaling by Receptor Tyrosine Kinases (Caenorhabditis elegans)
Signaling by PDGF (Caenorhabditis elegans)
Autophosphorylation of PDGF alpha receptors (Caenorhabditis elegans)
PDGFR:type I PDGFR-binding TKIs [plasma membrane] (Caenorhabditis elegans)
type I PDGFR-binding tyrosine kinase inhibitors [cytosol]
crenolanib [cytosol]
PDGFRs bind type I TKI (Caenorhabditis elegans)
type I PDGFR-binding tyrosine kinase inhibitors [cytosol]
crenolanib [cytosol]
PDGFR:type I PDGFR-binding TKIs [plasma membrane] (Caenorhabditis elegans)
type I PDGFR-binding tyrosine kinase inhibitors [cytosol]
crenolanib [cytosol]
Immune System (Canis familiaris)
Cytokine Signaling in Immune system (Canis familiaris)
FLT3 Signaling (Canis familiaris)
FLT3LG dimer:FLT3 dimer autophosphorylates (Canis familiaris)
FLT3LG dimer:FLT3:FLT3-binding type I TKIs [plasma membrane] (Canis familiaris)
type I FLT3-binding TKIs [cytosol]
crenolanib [cytosol]
Signal Transduction (Canis familiaris)
Signaling by Receptor Tyrosine Kinases (Canis familiaris)
Signaling by PDGF (Canis familiaris)
Autophosphorylation of PDGF alpha receptors (Canis familiaris)
PDGFR:type I PDGFR-binding TKIs [plasma membrane] (Canis familiaris)
type I PDGFR-binding tyrosine kinase inhibitors [cytosol]
crenolanib [cytosol]
PDGFRs bind type I TKI (Canis familiaris)
type I PDGFR-binding tyrosine kinase inhibitors [cytosol]
crenolanib [cytosol]
PDGFR:type I PDGFR-binding TKIs [plasma membrane] (Canis familiaris)
type I PDGFR-binding tyrosine kinase inhibitors [cytosol]
crenolanib [cytosol]
Signal Transduction (Danio rerio)
Signaling by Receptor Tyrosine Kinases (Danio rerio)
Signaling by PDGF (Danio rerio)
Autophosphorylation of PDGF alpha receptors (Danio rerio)
PDGFR:type I PDGFR-binding TKIs [plasma membrane] (Danio rerio)
type I PDGFR-binding tyrosine kinase inhibitors [cytosol]
crenolanib [cytosol]
PDGFRs bind type I TKI (Danio rerio)
type I PDGFR-binding tyrosine kinase inhibitors [cytosol]
crenolanib [cytosol]
PDGFR:type I PDGFR-binding TKIs [plasma membrane] (Danio rerio)
type I PDGFR-binding tyrosine kinase inhibitors [cytosol]
crenolanib [cytosol]
Signal Transduction (Drosophila melanogaster)
Signaling by Receptor Tyrosine Kinases (Drosophila melanogaster)
Signaling by PDGF (Drosophila melanogaster)
Autophosphorylation of PDGF alpha receptors (Drosophila melanogaster)
PDGFR:type I PDGFR-binding TKIs [plasma membrane] (Drosophila melanogaster)
type I PDGFR-binding tyrosine kinase inhibitors [cytosol]
crenolanib [cytosol]
PDGFRs bind type I TKI (Drosophila melanogaster)
type I PDGFR-binding tyrosine kinase inhibitors [cytosol]
crenolanib [cytosol]
PDGFR:type I PDGFR-binding TKIs [plasma membrane] (Drosophila melanogaster)
type I PDGFR-binding tyrosine kinase inhibitors [cytosol]
crenolanib [cytosol]
Signal Transduction (Gallus gallus)
Signaling by Receptor Tyrosine Kinases (Gallus gallus)
Signaling by PDGF (Gallus gallus)
Autophosphorylation of PDGF alpha receptors (Gallus gallus)
PDGFR:type I PDGFR-binding TKIs [plasma membrane] (Gallus gallus)
type I PDGFR-binding tyrosine kinase inhibitors [cytosol]
crenolanib [cytosol]
PDGFRs bind type I TKI (Gallus gallus)
type I PDGFR-binding tyrosine kinase inhibitors [cytosol]
crenolanib [cytosol]
PDGFR:type I PDGFR-binding TKIs [plasma membrane] (Gallus gallus)
type I PDGFR-binding tyrosine kinase inhibitors [cytosol]
crenolanib [cytosol]
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
FLT3 signaling in disease (Homo sapiens)
Drug resistance of FLT3 mutants (Homo sapiens)
crenolanib-resistant FLT3 mutants (Homo sapiens)
crenolanib-resistant FLT3 mutants don't bind crenolanib (Homo sapiens)
crenolanib [cytosol]
FLT3 mutants bind TKIs (Homo sapiens)
FLT mutants bind type I TKIs (Homo sapiens)
type I FLT3-binding TKIs [cytosol]
crenolanib [cytosol]
type I TKI-sensitive FLT3 mutants:type I TKIs [plasma membrane] (Homo sapiens)
type I FLT3-binding TKIs [cytosol]
crenolanib [cytosol]
Signaling by PDGFR in disease (Homo sapiens)
PDGFR mutants bind TKIs (Homo sapiens)
PDGFR mutants bind type I TKIs (Homo sapiens)
type I PDGFR-binding tyrosine kinase inhibitors [cytosol]
crenolanib [cytosol]
type I sensitive PDGFR mutants:type I TKIs [plasma membrane] (Homo sapiens)
type I PDGFR-binding tyrosine kinase inhibitors [cytosol]
crenolanib [cytosol]
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
FLT3 Signaling (Homo sapiens)
FLT3 binds type I TKI (Homo sapiens)
type I FLT3-binding TKIs [cytosol]
crenolanib [cytosol]
FLT3LG dimer:FLT3:FLT3-binding type I TKIs [plasma membrane] (Homo sapiens)
type I FLT3-binding TKIs [cytosol]
crenolanib [cytosol]
FLT3LG dimer:FLT3 dimer autophosphorylates (Homo sapiens)
type I FLT3-binding TKIs [cytosol]
crenolanib [cytosol]
FLT3LG dimer:FLT3:FLT3-binding type I TKIs [plasma membrane] (Homo sapiens)
type I FLT3-binding TKIs [cytosol]
crenolanib [cytosol]
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by PDGF (Homo sapiens)
Autophosphorylation of PDGF alpha receptors (Homo sapiens)
PDGFR:type I PDGFR-binding TKIs [plasma membrane] (Homo sapiens)
type I PDGFR-binding tyrosine kinase inhibitors [cytosol]
crenolanib [cytosol]
PDGFRs bind type I TKI (Homo sapiens)
type I PDGFR-binding tyrosine kinase inhibitors [cytosol]
crenolanib [cytosol]
PDGFR:type I PDGFR-binding TKIs [plasma membrane] (Homo sapiens)
type I PDGFR-binding tyrosine kinase inhibitors [cytosol]
crenolanib [cytosol]
Immune System (Mus musculus)
Cytokine Signaling in Immune system (Mus musculus)
FLT3 Signaling (Mus musculus)
FLT3LG dimer:FLT3 dimer autophosphorylates (Mus musculus)
FLT3LG dimer:FLT3:FLT3-binding type I TKIs [plasma membrane] (Mus musculus)
type I FLT3-binding TKIs [cytosol]
crenolanib [cytosol]
Signal Transduction (Mus musculus)
Signaling by Receptor Tyrosine Kinases (Mus musculus)
Signaling by PDGF (Mus musculus)
Autophosphorylation of PDGF alpha receptors (Mus musculus)
PDGFR:type I PDGFR-binding TKIs [plasma membrane] (Mus musculus)
type I PDGFR-binding tyrosine kinase inhibitors [cytosol]
crenolanib [cytosol]
PDGFRs bind type I TKI (Mus musculus)
type I PDGFR-binding tyrosine kinase inhibitors [cytosol]
crenolanib [cytosol]
PDGFR:type I PDGFR-binding TKIs [plasma membrane] (Mus musculus)
type I PDGFR-binding tyrosine kinase inhibitors [cytosol]
crenolanib [cytosol]
Signal Transduction (Rattus norvegicus)
Signaling by Receptor Tyrosine Kinases (Rattus norvegicus)
Signaling by PDGF (Rattus norvegicus)
Autophosphorylation of PDGF alpha receptors (Rattus norvegicus)
PDGFR:type I PDGFR-binding TKIs [plasma membrane] (Rattus norvegicus)
type I PDGFR-binding tyrosine kinase inhibitors [cytosol]
crenolanib [cytosol]
PDGFRs bind type I TKI (Rattus norvegicus)
type I PDGFR-binding tyrosine kinase inhibitors [cytosol]
crenolanib [cytosol]
PDGFR:type I PDGFR-binding TKIs [plasma membrane] (Rattus norvegicus)
type I PDGFR-binding tyrosine kinase inhibitors [cytosol]
crenolanib [cytosol]
Immune System (Sus scrofa)
Cytokine Signaling in Immune system (Sus scrofa)
FLT3 Signaling (Sus scrofa)
FLT3LG dimer:FLT3 dimer autophosphorylates (Sus scrofa)
FLT3LG dimer:FLT3:FLT3-binding type I TKIs [plasma membrane] (Sus scrofa)
type I FLT3-binding TKIs [cytosol]
crenolanib [cytosol]
Signal Transduction (Sus scrofa)
Signaling by Receptor Tyrosine Kinases (Sus scrofa)
Signaling by PDGF (Sus scrofa)
Autophosphorylation of PDGF alpha receptors (Sus scrofa)
PDGFR:type I PDGFR-binding TKIs [plasma membrane] (Sus scrofa)
type I PDGFR-binding tyrosine kinase inhibitors [cytosol]
crenolanib [cytosol]
PDGFRs bind type I TKI (Sus scrofa)
type I PDGFR-binding tyrosine kinase inhibitors [cytosol]
crenolanib [cytosol]
PDGFR:type I PDGFR-binding TKIs [plasma membrane] (Sus scrofa)
type I PDGFR-binding tyrosine kinase inhibitors [cytosol]
crenolanib [cytosol]
Immune System (Xenopus tropicalis)
Cytokine Signaling in Immune system (Xenopus tropicalis)
FLT3 Signaling (Xenopus tropicalis)
FLT3LG dimer:FLT3 dimer autophosphorylates (Xenopus tropicalis)
FLT3LG dimer:FLT3:FLT3-binding type I TKIs [plasma membrane] (Xenopus tropicalis)
type I FLT3-binding TKIs [cytosol]
crenolanib [cytosol]
External Reference Information
External Reference
crenolanib [Guide to Pharmacology:7882]
Participates
as an input of
crenolanib-resistant FLT3 mutants don't bind crenolanib (Homo sapiens)
as a member of
type I FLT3-binding TKIs [cytosol]
type I PDGFR-binding tyrosine kinase inhibitors [cytosol]
Disease
Name
Identifier
Synonyms
cancer
DOID:162
malignant tumor, malignant neoplasm, primary cancer
Cross References
Mondo
0004992
ChEBI
145365
PharmacoDB
PDBC02841
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