Reactome | selumetinib [cytosol]

selumetinib [cytosol]

Stable Identifier

R-ALL-9657511

Type

ChemicalDrug

Compartment

cytosol

Locations in the PathwayBrowser

for Species:

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Signal Transduction (Bos taurus)

- MAPK family signaling cascades (Bos taurus)
  - MAPK1/MAPK3 signaling (Bos taurus)
    - RAF/MAP kinase cascade (Bos taurus)
      - MAP2K and MAPK activation (Bos taurus)
        
        MAP2Ks phosphorylate MAPKs (Bos taurus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Bos taurus)
        
        single mechanism MAP2K1/2 inhibitors [cytosol]
        
        selumetinib [cytosol]
        
        Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Bos taurus)
        
        single mechanism MAP2K1/2 inhibitors [cytosol]
        
        selumetinib [cytosol]
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Bos taurus)
        
        single mechanism MAP2K1/2 inhibitors [cytosol]
        
        selumetinib [cytosol]

Signal Transduction (Caenorhabditis elegans)

- MAPK family signaling cascades (Caenorhabditis elegans)
  - MAPK1/MAPK3 signaling (Caenorhabditis elegans)
    - RAF/MAP kinase cascade (Caenorhabditis elegans)
      - MAP2K and MAPK activation (Caenorhabditis elegans)
        
        MAP2Ks phosphorylate MAPKs (Caenorhabditis elegans)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Caenorhabditis elegans)
        
        single mechanism MAP2K1/2 inhibitors [cytosol]
        
        selumetinib [cytosol]
        
        Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Caenorhabditis elegans)
        
        single mechanism MAP2K1/2 inhibitors [cytosol]
        
        selumetinib [cytosol]
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Caenorhabditis elegans)
        
        single mechanism MAP2K1/2 inhibitors [cytosol]
        
        selumetinib [cytosol]

Signal Transduction (Canis familiaris)

- MAPK family signaling cascades (Canis familiaris)
  - MAPK1/MAPK3 signaling (Canis familiaris)
    - RAF/MAP kinase cascade (Canis familiaris)
      - MAP2K and MAPK activation (Canis familiaris)
        
        MAP2Ks phosphorylate MAPKs (Canis familiaris)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Canis familiaris)
        
        single mechanism MAP2K1/2 inhibitors [cytosol]
        
        selumetinib [cytosol]
        
        Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Canis familiaris)
        
        single mechanism MAP2K1/2 inhibitors [cytosol]
        
        selumetinib [cytosol]
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Canis familiaris)
        
        single mechanism MAP2K1/2 inhibitors [cytosol]
        
        selumetinib [cytosol]

Signal Transduction (Drosophila melanogaster)

- MAPK family signaling cascades (Drosophila melanogaster)
  - MAPK1/MAPK3 signaling (Drosophila melanogaster)
    - RAF/MAP kinase cascade (Drosophila melanogaster)
      - MAP2K and MAPK activation (Drosophila melanogaster)
        
        MAP2Ks phosphorylate MAPKs (Drosophila melanogaster)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Drosophila melanogaster)
        
        single mechanism MAP2K1/2 inhibitors [cytosol]
        
        selumetinib [cytosol]
        
        Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Drosophila melanogaster)
        
        single mechanism MAP2K1/2 inhibitors [cytosol]
        
        selumetinib [cytosol]
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Drosophila melanogaster)
        
        single mechanism MAP2K1/2 inhibitors [cytosol]
        
        selumetinib [cytosol]

Signal Transduction (Gallus gallus)

- MAPK family signaling cascades (Gallus gallus)
  - MAPK1/MAPK3 signaling (Gallus gallus)
    - RAF/MAP kinase cascade (Gallus gallus)
      - MAP2K and MAPK activation (Gallus gallus)
        
        MAP2Ks phosphorylate MAPKs (Gallus gallus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Gallus gallus)
        
        single mechanism MAP2K1/2 inhibitors [cytosol]
        
        selumetinib [cytosol]
        
        Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Gallus gallus)
        
        single mechanism MAP2K1/2 inhibitors [cytosol]
        
        selumetinib [cytosol]
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Gallus gallus)
        
        single mechanism MAP2K1/2 inhibitors [cytosol]
        
        selumetinib [cytosol]

Signal Transduction (Homo sapiens)

- MAPK family signaling cascades (Homo sapiens)
  - MAPK1/MAPK3 signaling (Homo sapiens)
    - RAF/MAP kinase cascade (Homo sapiens)
      - MAP2K and MAPK activation (Homo sapiens)
        
        MAP2Ks phosphorylate MAPKs (Homo sapiens)
        
        single mechanism MAP2K1/2 inhibitors [cytosol]
        
        selumetinib [cytosol]
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
        
        single mechanism MAP2K1/2 inhibitors [cytosol]
        
        selumetinib [cytosol]
        
        Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Homo sapiens)
        
        single mechanism MAP2K1/2 inhibitors [cytosol]
        
        selumetinib [cytosol]
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Homo sapiens)
        
        single mechanism MAP2K1/2 inhibitors [cytosol]
        
        selumetinib [cytosol]

Signal Transduction (Mus musculus)

- MAPK family signaling cascades (Mus musculus)
  - MAPK1/MAPK3 signaling (Mus musculus)
    - RAF/MAP kinase cascade (Mus musculus)
      - MAP2K and MAPK activation (Mus musculus)
        
        MAP2Ks phosphorylate MAPKs (Mus musculus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Mus musculus)
        
        single mechanism MAP2K1/2 inhibitors [cytosol]
        
        selumetinib [cytosol]
        
        Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Mus musculus)
        
        single mechanism MAP2K1/2 inhibitors [cytosol]
        
        selumetinib [cytosol]
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Mus musculus)
        
        single mechanism MAP2K1/2 inhibitors [cytosol]
        
        selumetinib [cytosol]

Signal Transduction (Rattus norvegicus)

- MAPK family signaling cascades (Rattus norvegicus)
  - MAPK1/MAPK3 signaling (Rattus norvegicus)
    - RAF/MAP kinase cascade (Rattus norvegicus)
      - MAP2K and MAPK activation (Rattus norvegicus)
        
        MAP2Ks phosphorylate MAPKs (Rattus norvegicus)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Rattus norvegicus)
        
        single mechanism MAP2K1/2 inhibitors [cytosol]
        
        selumetinib [cytosol]
        
        Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Rattus norvegicus)
        
        single mechanism MAP2K1/2 inhibitors [cytosol]
        
        selumetinib [cytosol]
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Rattus norvegicus)
        
        single mechanism MAP2K1/2 inhibitors [cytosol]
        
        selumetinib [cytosol]

Signal Transduction (Sus scrofa)

- MAPK family signaling cascades (Sus scrofa)
  - MAPK1/MAPK3 signaling (Sus scrofa)
    - RAF/MAP kinase cascade (Sus scrofa)
      - MAP2K and MAPK activation (Sus scrofa)
        
        MAP2Ks phosphorylate MAPKs (Sus scrofa)
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Sus scrofa)
        
        single mechanism MAP2K1/2 inhibitors [cytosol]
        
        selumetinib [cytosol]
        
        Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Sus scrofa)
        
        single mechanism MAP2K1/2 inhibitors [cytosol]
        
        selumetinib [cytosol]
        
        activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Sus scrofa)
        
        single mechanism MAP2K1/2 inhibitors [cytosol]
        
        selumetinib [cytosol]

Literature References

PubMed ID	Title	Journal	Year
17332304	Biological characterization of ARRY-142886 (AZD6244), a potent, highly selective mitogen-activated protein kinase kinase 1/2 inhibitor Bernat, BA, Marsh, V, Parry, J, Yeh, TC, Evans, RJ, Lee, PA, Gross, S, Wallace, E, Colwell, H, Hurley, B, Marlow, A, Koch, K, Brandhuber, BJ, Lyssikatos, J, Ballard, J, Smith, D, Winkler, JD	Clin. Cancer Res.	2007
17237274	Targeted inhibition of the extracellular signal-regulated kinase kinase pathway with AZD6244 (ARRY-142886) in the treatment of hepatocellular carcinoma Huynh, H, Soo, KC, Chow, PK, Tran, E	Mol. Cancer Ther.	2007

External Reference Information

External Reference

selumetinib [Guide to Pharmacology:5665]

Participates

as a candidate of

single mechanism MAP2K1/2 inhibitors [cytosol]

Disease

Name	Identifier	Synonyms
cancer	DOID:162	malignant tumor, malignant neoplasm, primary cancer

Cross References

ChEBI

90227

PharmacoDB

PDBC00053

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