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nintedanib [cytosol]
Stable Identifier
R-ALL-9616923
Type
ChemicalDrug
Compartment
cytosol
Synonyms
BIBF 1120, BIBF1120, BIBF-1120, methyl (3Z)-3-((4-{methyl((4-methylpiperazin-1-yl)acetyl)amino}anilino)(phenyl)methylidene)-2-oxo-2,3-dihydro-1H-indole-6-carboxylate
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Drosophila melanogaster
Gallus gallus
Mus musculus
Rattus norvegicus
Sus scrofa
Xenopus tropicalis
Expand all
Signal Transduction (Bos taurus)
Signaling by Receptor Tyrosine Kinases (Bos taurus)
Signaling by PDGF (Bos taurus)
PDGF dimer binds two receptors simultaneously (Bos taurus)
PDGFR:type II PDGFR-binding TKIs [plasma membrane] (Bos taurus)
type II PDGFR-binding tyrosine kinase inhibitors [cytosol]
nintedanib [cytosol]
PDGFRs bind type II TKI (Bos taurus)
type II PDGFR-binding tyrosine kinase inhibitors [cytosol]
nintedanib [cytosol]
PDGFR:type II PDGFR-binding TKIs [plasma membrane] (Bos taurus)
type II PDGFR-binding tyrosine kinase inhibitors [cytosol]
nintedanib [cytosol]
Signal Transduction (Caenorhabditis elegans)
Signaling by Receptor Tyrosine Kinases (Caenorhabditis elegans)
Signaling by PDGF (Caenorhabditis elegans)
PDGF dimer binds two receptors simultaneously (Caenorhabditis elegans)
PDGFR:type II PDGFR-binding TKIs [plasma membrane] (Caenorhabditis elegans)
type II PDGFR-binding tyrosine kinase inhibitors [cytosol]
nintedanib [cytosol]
PDGFRs bind type II TKI (Caenorhabditis elegans)
type II PDGFR-binding tyrosine kinase inhibitors [cytosol]
nintedanib [cytosol]
PDGFR:type II PDGFR-binding TKIs [plasma membrane] (Caenorhabditis elegans)
type II PDGFR-binding tyrosine kinase inhibitors [cytosol]
nintedanib [cytosol]
Signal Transduction (Canis familiaris)
Signaling by Receptor Tyrosine Kinases (Canis familiaris)
Signaling by PDGF (Canis familiaris)
PDGF dimer binds two receptors simultaneously (Canis familiaris)
PDGFR:type II PDGFR-binding TKIs [plasma membrane] (Canis familiaris)
type II PDGFR-binding tyrosine kinase inhibitors [cytosol]
nintedanib [cytosol]
PDGFRs bind type II TKI (Canis familiaris)
type II PDGFR-binding tyrosine kinase inhibitors [cytosol]
nintedanib [cytosol]
PDGFR:type II PDGFR-binding TKIs [plasma membrane] (Canis familiaris)
type II PDGFR-binding tyrosine kinase inhibitors [cytosol]
nintedanib [cytosol]
Signal Transduction (Danio rerio)
Signaling by Receptor Tyrosine Kinases (Danio rerio)
Signaling by PDGF (Danio rerio)
PDGF dimer binds two receptors simultaneously (Danio rerio)
PDGFR:type II PDGFR-binding TKIs [plasma membrane] (Danio rerio)
type II PDGFR-binding tyrosine kinase inhibitors [cytosol]
nintedanib [cytosol]
PDGFRs bind type II TKI (Danio rerio)
type II PDGFR-binding tyrosine kinase inhibitors [cytosol]
nintedanib [cytosol]
PDGFR:type II PDGFR-binding TKIs [plasma membrane] (Danio rerio)
type II PDGFR-binding tyrosine kinase inhibitors [cytosol]
nintedanib [cytosol]
Signal Transduction (Drosophila melanogaster)
Signaling by Receptor Tyrosine Kinases (Drosophila melanogaster)
Signaling by PDGF (Drosophila melanogaster)
PDGF dimer binds two receptors simultaneously (Drosophila melanogaster)
PDGFR:type II PDGFR-binding TKIs [plasma membrane] (Drosophila melanogaster)
type II PDGFR-binding tyrosine kinase inhibitors [cytosol]
nintedanib [cytosol]
PDGFRs bind type II TKI (Drosophila melanogaster)
type II PDGFR-binding tyrosine kinase inhibitors [cytosol]
nintedanib [cytosol]
PDGFR:type II PDGFR-binding TKIs [plasma membrane] (Drosophila melanogaster)
type II PDGFR-binding tyrosine kinase inhibitors [cytosol]
nintedanib [cytosol]
Signal Transduction (Gallus gallus)
Signaling by Receptor Tyrosine Kinases (Gallus gallus)
Signaling by PDGF (Gallus gallus)
PDGF dimer binds two receptors simultaneously (Gallus gallus)
PDGFR:type II PDGFR-binding TKIs [plasma membrane] (Gallus gallus)
type II PDGFR-binding tyrosine kinase inhibitors [cytosol]
nintedanib [cytosol]
PDGFRs bind type II TKI (Gallus gallus)
type II PDGFR-binding tyrosine kinase inhibitors [cytosol]
nintedanib [cytosol]
PDGFR:type II PDGFR-binding TKIs [plasma membrane] (Gallus gallus)
type II PDGFR-binding tyrosine kinase inhibitors [cytosol]
nintedanib [cytosol]
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Signaling by FGFR in disease (Homo sapiens)
Signaling by FGFR3 in disease (Homo sapiens)
FGFR3 mutants bind and are inactivated by tyrosine kinase inhibitors (Homo sapiens)
Tyrosine kinase inhibitors of FGFR3 mutants [cytosol]
nintedanib [cytosol]
FGFR3 mutant dimers:TKIs [plasma membrane] (Homo sapiens)
Tyrosine kinase inhibitors of FGFR3 mutants [cytosol]
nintedanib [cytosol]
Signaling by PDGFR in disease (Homo sapiens)
PDGFR mutants bind TKIs (Homo sapiens)
PDGFR mutants bind type II TKIs (Homo sapiens)
type II PDGFR-binding tyrosine kinase inhibitors [cytosol]
nintedanib [cytosol]
type II sensitive PDGFR mutants:type II TKIs [plasma membrane] (Homo sapiens)
type II PDGFR-binding tyrosine kinase inhibitors [cytosol]
nintedanib [cytosol]
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by PDGF (Homo sapiens)
PDGF dimer binds two receptors simultaneously (Homo sapiens)
PDGFR:type II PDGFR-binding TKIs [plasma membrane] (Homo sapiens)
type II PDGFR-binding tyrosine kinase inhibitors [cytosol]
nintedanib [cytosol]
PDGFRs bind type II TKI (Homo sapiens)
type II PDGFR-binding tyrosine kinase inhibitors [cytosol]
nintedanib [cytosol]
PDGFR:type II PDGFR-binding TKIs [plasma membrane] (Homo sapiens)
type II PDGFR-binding tyrosine kinase inhibitors [cytosol]
nintedanib [cytosol]
Signal Transduction (Mus musculus)
Signaling by Receptor Tyrosine Kinases (Mus musculus)
Signaling by PDGF (Mus musculus)
PDGF dimer binds two receptors simultaneously (Mus musculus)
PDGFR:type II PDGFR-binding TKIs [plasma membrane] (Mus musculus)
type II PDGFR-binding tyrosine kinase inhibitors [cytosol]
nintedanib [cytosol]
PDGFRs bind type II TKI (Mus musculus)
type II PDGFR-binding tyrosine kinase inhibitors [cytosol]
nintedanib [cytosol]
PDGFR:type II PDGFR-binding TKIs [plasma membrane] (Mus musculus)
type II PDGFR-binding tyrosine kinase inhibitors [cytosol]
nintedanib [cytosol]
Signal Transduction (Rattus norvegicus)
Signaling by Receptor Tyrosine Kinases (Rattus norvegicus)
Signaling by PDGF (Rattus norvegicus)
PDGF dimer binds two receptors simultaneously (Rattus norvegicus)
PDGFR:type II PDGFR-binding TKIs [plasma membrane] (Rattus norvegicus)
type II PDGFR-binding tyrosine kinase inhibitors [cytosol]
nintedanib [cytosol]
PDGFRs bind type II TKI (Rattus norvegicus)
type II PDGFR-binding tyrosine kinase inhibitors [cytosol]
nintedanib [cytosol]
PDGFR:type II PDGFR-binding TKIs [plasma membrane] (Rattus norvegicus)
type II PDGFR-binding tyrosine kinase inhibitors [cytosol]
nintedanib [cytosol]
Signal Transduction (Sus scrofa)
Signaling by Receptor Tyrosine Kinases (Sus scrofa)
Signaling by PDGF (Sus scrofa)
PDGF dimer binds two receptors simultaneously (Sus scrofa)
PDGFR:type II PDGFR-binding TKIs [plasma membrane] (Sus scrofa)
type II PDGFR-binding tyrosine kinase inhibitors [cytosol]
nintedanib [cytosol]
PDGFRs bind type II TKI (Sus scrofa)
type II PDGFR-binding tyrosine kinase inhibitors [cytosol]
nintedanib [cytosol]
PDGFR:type II PDGFR-binding TKIs [plasma membrane] (Sus scrofa)
type II PDGFR-binding tyrosine kinase inhibitors [cytosol]
nintedanib [cytosol]
Signal Transduction (Xenopus tropicalis)
Signaling by Receptor Tyrosine Kinases (Xenopus tropicalis)
Signaling by PDGF (Xenopus tropicalis)
PDGF dimer binds two receptors simultaneously (Xenopus tropicalis)
PDGFR:type II PDGFR-binding TKIs [plasma membrane] (Xenopus tropicalis)
type II PDGFR-binding tyrosine kinase inhibitors [cytosol]
nintedanib [cytosol]
PDGFRs bind type II TKI (Xenopus tropicalis)
type II PDGFR-binding tyrosine kinase inhibitors [cytosol]
nintedanib [cytosol]
PDGFR:type II PDGFR-binding TKIs [plasma membrane] (Xenopus tropicalis)
type II PDGFR-binding tyrosine kinase inhibitors [cytosol]
nintedanib [cytosol]
External Reference Information
External Reference
nintedanib [Guide to Pharmacology:5936]
Participates
as a member of
Tyrosine kinase inhibitors of FGFR3 mutants [cytosol]
type II PDGFR-binding tyrosine kinase inhibitors [cytosol]
Disease
Name
Identifier
Synonyms
cancer
DOID:162
malignant tumor, malignant neoplasm, primary cancer
Cross References
ChEBI
85164
Pharos - Ligands
41D7PT4QXULZ
PharmacoDB
PDBC01871
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