Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
diltiazem [extracellular region]
Stable Identifier
R-ALL-9614110
Type
ChemicalDrug
Compartment
extracellular region
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Drosophila melanogaster
Gallus gallus
Mus musculus
Rattus norvegicus
Sus scrofa
Xenopus tropicalis
Expand all
Muscle contraction (Bos taurus)
Cardiac conduction (Bos taurus)
Phase 0 - rapid depolarisation (Bos taurus)
LTCC multimer transports Ca2+ from extracellular region to cytosol (Bos taurus)
Class IV antihypertensives:LTCC multimer [plasma membrane] (Bos taurus)
Class IV antihypertensives [extracellular region]
diltiazem [extracellular region]
Phase 2 - plateau phase (Bos taurus)
Class IV antihypertensives bind LTCC multimer (Bos taurus)
Class IV antihypertensives [extracellular region]
diltiazem [extracellular region]
Class IV antihypertensives:LTCC multimer [plasma membrane] (Bos taurus)
Class IV antihypertensives [extracellular region]
diltiazem [extracellular region]
LTCC multimer transports Ca2+ from extracellular region to cytosol (Bos taurus)
Class IV antihypertensives:LTCC multimer [plasma membrane] (Bos taurus)
Class IV antihypertensives [extracellular region]
diltiazem [extracellular region]
Muscle contraction (Caenorhabditis elegans)
Cardiac conduction (Caenorhabditis elegans)
Phase 0 - rapid depolarisation (Caenorhabditis elegans)
LTCC multimer transports Ca2+ from extracellular region to cytosol (Caenorhabditis elegans)
Class IV antihypertensives:LTCC multimer [plasma membrane] (Caenorhabditis elegans)
Class IV antihypertensives [extracellular region]
diltiazem [extracellular region]
Phase 2 - plateau phase (Caenorhabditis elegans)
Class IV antihypertensives bind LTCC multimer (Caenorhabditis elegans)
Class IV antihypertensives [extracellular region]
diltiazem [extracellular region]
Class IV antihypertensives:LTCC multimer [plasma membrane] (Caenorhabditis elegans)
Class IV antihypertensives [extracellular region]
diltiazem [extracellular region]
LTCC multimer transports Ca2+ from extracellular region to cytosol (Caenorhabditis elegans)
Class IV antihypertensives:LTCC multimer [plasma membrane] (Caenorhabditis elegans)
Class IV antihypertensives [extracellular region]
diltiazem [extracellular region]
Muscle contraction (Canis familiaris)
Cardiac conduction (Canis familiaris)
Phase 0 - rapid depolarisation (Canis familiaris)
LTCC multimer transports Ca2+ from extracellular region to cytosol (Canis familiaris)
Class IV antihypertensives:LTCC multimer [plasma membrane] (Canis familiaris)
Class IV antihypertensives [extracellular region]
diltiazem [extracellular region]
Phase 2 - plateau phase (Canis familiaris)
Class IV antihypertensives bind LTCC multimer (Canis familiaris)
Class IV antihypertensives [extracellular region]
diltiazem [extracellular region]
Class IV antihypertensives:LTCC multimer [plasma membrane] (Canis familiaris)
Class IV antihypertensives [extracellular region]
diltiazem [extracellular region]
LTCC multimer transports Ca2+ from extracellular region to cytosol (Canis familiaris)
Class IV antihypertensives:LTCC multimer [plasma membrane] (Canis familiaris)
Class IV antihypertensives [extracellular region]
diltiazem [extracellular region]
Muscle contraction (Drosophila melanogaster)
Cardiac conduction (Drosophila melanogaster)
Phase 0 - rapid depolarisation (Drosophila melanogaster)
LTCC multimer transports Ca2+ from extracellular region to cytosol (Drosophila melanogaster)
Class IV antihypertensives:LTCC multimer [plasma membrane] (Drosophila melanogaster)
Class IV antihypertensives [extracellular region]
diltiazem [extracellular region]
Phase 2 - plateau phase (Drosophila melanogaster)
Class IV antihypertensives bind LTCC multimer (Drosophila melanogaster)
Class IV antihypertensives [extracellular region]
diltiazem [extracellular region]
Class IV antihypertensives:LTCC multimer [plasma membrane] (Drosophila melanogaster)
Class IV antihypertensives [extracellular region]
diltiazem [extracellular region]
LTCC multimer transports Ca2+ from extracellular region to cytosol (Drosophila melanogaster)
Class IV antihypertensives:LTCC multimer [plasma membrane] (Drosophila melanogaster)
Class IV antihypertensives [extracellular region]
diltiazem [extracellular region]
Muscle contraction (Gallus gallus)
Cardiac conduction (Gallus gallus)
Phase 0 - rapid depolarisation (Gallus gallus)
LTCC multimer transports Ca2+ from extracellular region to cytosol (Gallus gallus)
Class IV antihypertensives:LTCC multimer [plasma membrane] (Gallus gallus)
Class IV antihypertensives [extracellular region]
diltiazem [extracellular region]
Phase 2 - plateau phase (Gallus gallus)
Class IV antihypertensives bind LTCC multimer (Gallus gallus)
Class IV antihypertensives [extracellular region]
diltiazem [extracellular region]
Class IV antihypertensives:LTCC multimer [plasma membrane] (Gallus gallus)
Class IV antihypertensives [extracellular region]
diltiazem [extracellular region]
LTCC multimer transports Ca2+ from extracellular region to cytosol (Gallus gallus)
Class IV antihypertensives:LTCC multimer [plasma membrane] (Gallus gallus)
Class IV antihypertensives [extracellular region]
diltiazem [extracellular region]
Muscle contraction (Homo sapiens)
Cardiac conduction (Homo sapiens)
Phase 0 - rapid depolarisation (Homo sapiens)
LTCC multimer transports Ca2+ from extracellular region to cytosol (Homo sapiens)
Class IV antihypertensives:LTCC multimer [plasma membrane] (Homo sapiens)
Class IV antihypertensives [extracellular region]
diltiazem [extracellular region]
Phase 2 - plateau phase (Homo sapiens)
Class IV antihypertensives bind LTCC multimer (Homo sapiens)
Class IV antihypertensives [extracellular region]
diltiazem [extracellular region]
Class IV antihypertensives:LTCC multimer [plasma membrane] (Homo sapiens)
Class IV antihypertensives [extracellular region]
diltiazem [extracellular region]
LTCC multimer transports Ca2+ from extracellular region to cytosol (Homo sapiens)
Class IV antihypertensives:LTCC multimer [plasma membrane] (Homo sapiens)
Class IV antihypertensives [extracellular region]
diltiazem [extracellular region]
Muscle contraction (Mus musculus)
Cardiac conduction (Mus musculus)
Phase 0 - rapid depolarisation (Mus musculus)
LTCC multimer transports Ca2+ from extracellular region to cytosol (Mus musculus)
Class IV antihypertensives:LTCC multimer [plasma membrane] (Mus musculus)
Class IV antihypertensives [extracellular region]
diltiazem [extracellular region]
Phase 2 - plateau phase (Mus musculus)
Class IV antihypertensives bind LTCC multimer (Mus musculus)
Class IV antihypertensives [extracellular region]
diltiazem [extracellular region]
Class IV antihypertensives:LTCC multimer [plasma membrane] (Mus musculus)
Class IV antihypertensives [extracellular region]
diltiazem [extracellular region]
LTCC multimer transports Ca2+ from extracellular region to cytosol (Mus musculus)
Class IV antihypertensives:LTCC multimer [plasma membrane] (Mus musculus)
Class IV antihypertensives [extracellular region]
diltiazem [extracellular region]
Muscle contraction (Rattus norvegicus)
Cardiac conduction (Rattus norvegicus)
Phase 0 - rapid depolarisation (Rattus norvegicus)
LTCC multimer transports Ca2+ from extracellular region to cytosol (Rattus norvegicus)
Class IV antihypertensives:LTCC multimer [plasma membrane] (Rattus norvegicus)
Class IV antihypertensives [extracellular region]
diltiazem [extracellular region]
Phase 2 - plateau phase (Rattus norvegicus)
Class IV antihypertensives bind LTCC multimer (Rattus norvegicus)
Class IV antihypertensives [extracellular region]
diltiazem [extracellular region]
Class IV antihypertensives:LTCC multimer [plasma membrane] (Rattus norvegicus)
Class IV antihypertensives [extracellular region]
diltiazem [extracellular region]
LTCC multimer transports Ca2+ from extracellular region to cytosol (Rattus norvegicus)
Class IV antihypertensives:LTCC multimer [plasma membrane] (Rattus norvegicus)
Class IV antihypertensives [extracellular region]
diltiazem [extracellular region]
Muscle contraction (Sus scrofa)
Cardiac conduction (Sus scrofa)
Phase 0 - rapid depolarisation (Sus scrofa)
LTCC multimer transports Ca2+ from extracellular region to cytosol (Sus scrofa)
Class IV antihypertensives:LTCC multimer [plasma membrane] (Sus scrofa)
Class IV antihypertensives [extracellular region]
diltiazem [extracellular region]
Phase 2 - plateau phase (Sus scrofa)
Class IV antihypertensives bind LTCC multimer (Sus scrofa)
Class IV antihypertensives [extracellular region]
diltiazem [extracellular region]
Class IV antihypertensives:LTCC multimer [plasma membrane] (Sus scrofa)
Class IV antihypertensives [extracellular region]
diltiazem [extracellular region]
LTCC multimer transports Ca2+ from extracellular region to cytosol (Sus scrofa)
Class IV antihypertensives:LTCC multimer [plasma membrane] (Sus scrofa)
Class IV antihypertensives [extracellular region]
diltiazem [extracellular region]
Muscle contraction (Xenopus tropicalis)
Cardiac conduction (Xenopus tropicalis)
Phase 0 - rapid depolarisation (Xenopus tropicalis)
LTCC multimer transports Ca2+ from extracellular region to cytosol (Xenopus tropicalis)
Class IV antihypertensives:LTCC multimer [plasma membrane] (Xenopus tropicalis)
Class IV antihypertensives [extracellular region]
diltiazem [extracellular region]
Phase 2 - plateau phase (Xenopus tropicalis)
Class IV antihypertensives bind LTCC multimer (Xenopus tropicalis)
Class IV antihypertensives [extracellular region]
diltiazem [extracellular region]
Class IV antihypertensives:LTCC multimer [plasma membrane] (Xenopus tropicalis)
Class IV antihypertensives [extracellular region]
diltiazem [extracellular region]
LTCC multimer transports Ca2+ from extracellular region to cytosol (Xenopus tropicalis)
Class IV antihypertensives:LTCC multimer [plasma membrane] (Xenopus tropicalis)
Class IV antihypertensives [extracellular region]
diltiazem [extracellular region]
Literature References
PubMed ID
Title
Journal
Year
3891302
Diltiazem. A review of its pharmacological properties and therapeutic efficacy
Chaffman, M
,
Brogden, RN
Drugs
1985
10226758
The pharmacological basis and pathophysiological significance of the heart rate-lowering property of diltiazem
O'Connor, SE
,
Grosset, A
,
Janiak, P
Fundam Clin Pharmacol
1999
1990741
Comparative clinical pharmacology of calcium channel blockers
Kim, KE
Am Fam Physician
1991
External Reference Information
External Reference
diltiazem [Guide to Pharmacology:2298]
Participates
as a member of
Class IV antihypertensives [extracellular region]
Disease
Name
Identifier
Synonyms
intermediate coronary syndrome
DOID:8805
Unstable angina, Angina at rest, Worsening angina, Impending infarction, Preinfarction angina, Anginal chest pain at rest
Arrhythmia
SYMP:0000287
hypertension
DOID:10763
High blood pressure (& [essential hypertension]), HTN, hypertensive disease, hyperpiesia, vascular hypertensive disorder
migraine
DOID:6364
migraine variant, migraine disorder, migraine with or without aura
Cross References
Mondo
0006805
ChEBI
101278
,
101278
Pharos - Ligands
CV8BFLDQ99B6
© 2026
Reactome
This website requires cookies and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our
Privacy Notice
.
I agree, dismiss this banner
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text
