Reactome | PLX-4720 [cytosol]

PLX-4720 [cytosol]

Stable Identifier

R-ALL-6802250

Type

ChemicalDrug

Compartment

cytosol

Synonyms

C17H14ClF2N3O3S, N-(3-(5-chloro-1H-pyrrolo(2,3-b)pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide

Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
  - Oncogenic MAPK signaling (Homo sapiens)
    - Paradoxical activation of RAF signaling by kinase inactive BRAF (Homo sapiens)
      - Activated MAP2Ks phosphorylate MAPKs downstream of inactive BRAF mutants (Homo sapiens)
        
        RAS:GTP: inactive p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
        
        mutant RAS:inactive BRAF:p-S338,T491,S494,S729 RAF1 [plasma membrane] (Homo sapiens)
        
        genetically or chemically inactive BRAF [cytosol] (Homo sapiens)
        
        WT BRAF:inhibitors [cytosol] (Homo sapiens)
        
        PLX-4720 [cytosol]
        
        RAS:GTP:inactive p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
        
        mutant RAS:inactive BRAF:p-S338,T491,S494,S729 RAF1 [plasma membrane] (Homo sapiens)
        
        genetically or chemically inactive BRAF [cytosol] (Homo sapiens)
        
        WT BRAF:inhibitors [cytosol] (Homo sapiens)
        
        PLX-4720 [cytosol]
      - Dissociation of paradoxically activated RAS:BRAF complexes (Homo sapiens)
        
        RAS:GTP:inactive p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
        
        mutant RAS:inactive BRAF:p-S338,T491,S494,S729 RAF1 [plasma membrane] (Homo sapiens)
        
        genetically or chemically inactive BRAF [cytosol] (Homo sapiens)
        
        WT BRAF:inhibitors [cytosol] (Homo sapiens)
        
        PLX-4720 [cytosol]
        
        mutant RAS:inactive BRAF:p-S338,T491,S494,S729 RAF1 [plasma membrane] (Homo sapiens)
        
        genetically or chemically inactive BRAF [cytosol] (Homo sapiens)
        
        WT BRAF:inhibitors [cytosol] (Homo sapiens)
        
        PLX-4720 [cytosol]
      - Inactive BRAF mutants bind mutant RAS:GTP (Homo sapiens)
        
        chemically or genetically inactive BRAF mutants:mutant RAS:GTP [plasma membrane] (Homo sapiens)
        
        genetically or chemically inactive BRAF [cytosol] (Homo sapiens)
        
        WT BRAF:inhibitors [cytosol] (Homo sapiens)
        
        PLX-4720 [cytosol]
        
        genetically or chemically inactive BRAF [cytosol] (Homo sapiens)
        
        WT BRAF:inhibitors [cytosol] (Homo sapiens)
        
        PLX-4720 [cytosol]
      - Inactive BRAF mutants:mutant RAS:GTP bind RAF1 (Homo sapiens)
        
        chemically or genetically inactive BRAF mutants:mutant RAS:GTP [plasma membrane] (Homo sapiens)
        
        genetically or chemically inactive BRAF [cytosol] (Homo sapiens)
        
        WT BRAF:inhibitors [cytosol] (Homo sapiens)
        
        PLX-4720 [cytosol]
        
        mutant RAS:inactive BRAF:RAF1 [plasma membrane] (Homo sapiens)
        
        genetically or chemically inactive BRAF [cytosol] (Homo sapiens)
        
        WT BRAF:inhibitors [cytosol] (Homo sapiens)
        
        PLX-4720 [cytosol]
      - RAF is paradoxically phosphorylated downstream of kinase-inactive RAF (Homo sapiens)
        
        mutant RAS:inactive BRAF:RAF1 [plasma membrane] (Homo sapiens)
        
        genetically or chemically inactive BRAF [cytosol] (Homo sapiens)
        
        WT BRAF:inhibitors [cytosol] (Homo sapiens)
        
        PLX-4720 [cytosol]
        
        mutant RAS:inactive BRAF:p-S338,T491,S494,S729 RAF1 [plasma membrane] (Homo sapiens)
        
        genetically or chemically inactive BRAF [cytosol] (Homo sapiens)
        
        WT BRAF:inhibitors [cytosol] (Homo sapiens)
        
        PLX-4720 [cytosol]
      - RAS:GTP:inactive p-RAF complexes phosphorylate MAP2Ks (Homo sapiens)
        
        RAS:GTP: inactive p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
        
        mutant RAS:inactive BRAF:p-S338,T491,S494,S729 RAF1 [plasma membrane] (Homo sapiens)
        
        genetically or chemically inactive BRAF [cytosol] (Homo sapiens)
        
        WT BRAF:inhibitors [cytosol] (Homo sapiens)
        
        PLX-4720 [cytosol]
        
        RAS:GTP:inactive p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
        
        mutant RAS:inactive BRAF:p-S338,T491,S494,S729 RAF1 [plasma membrane] (Homo sapiens)
        
        genetically or chemically inactive BRAF [cytosol] (Homo sapiens)
        
        WT BRAF:inhibitors [cytosol] (Homo sapiens)
        
        PLX-4720 [cytosol]
      - RAS:GTP:p-RAF complexes paradoxically bind MAP2Ks and MAPKs (Homo sapiens)
        
        RAS:GTP:inactive p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
        
        mutant RAS:inactive BRAF:p-S338,T491,S494,S729 RAF1 [plasma membrane] (Homo sapiens)
        
        genetically or chemically inactive BRAF [cytosol] (Homo sapiens)
        
        WT BRAF:inhibitors [cytosol] (Homo sapiens)
        
        PLX-4720 [cytosol]
        
        mutant RAS:inactive BRAF:p-S338,T491,S494,S729 RAF1 [plasma membrane] (Homo sapiens)
        
        genetically or chemically inactive BRAF [cytosol] (Homo sapiens)
        
        WT BRAF:inhibitors [cytosol] (Homo sapiens)
        
        PLX-4720 [cytosol]
    - Signaling by high-kinase activity BRAF mutants (Homo sapiens)
      - Inhibitors bind and inhibit highly active BRAF mutants (Homo sapiens)
        
        BRAF inhibitors [cytosol]
        
        PLX-4720 [cytosol]
        
        BRAF inhibitors:high kinase activity BRAF mutants [cytosol] (Homo sapiens)
        
        BRAF inhibitors [cytosol]
        
        PLX-4720 [cytosol]

External Reference Information

External Reference

PLX-4720 [Guide to Pharmacology:5703]

Participates

as a component of

WT BRAF:inhibitors [cytosol] (Homo sapiens)

as a candidate of

BRAF inhibitors [cytosol]

Disease

Name	Identifier	Synonyms
cancer	DOID:162	malignant tumor, malignant neoplasm, primary cancer

Cross References

ChEBI

90295

PharmacoDB

PDBC00033

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