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AscH- [nucleoplasm]
Stable Identifier
R-ALL-5251226
Type
Chemical Compound [SimpleEntity]
Compartment
nucleoplasm
Synonyms
Ascorbate
Icon
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Drosophila melanogaster
Gallus gallus
Mus musculus
Rattus norvegicus
Sus scrofa
Xenopus tropicalis
Expand all
Cellular responses to stimuli (Bos taurus)
Cellular responses to stress (Bos taurus)
Cellular response to hypoxia (Bos taurus)
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Bos taurus)
Nuclear PHD1,3 hydroxylates proline residues on HIF1A (Bos taurus)
PHD1,3 [nucleoplasm] (Bos taurus)
EGLN2:AscH-:Fe2+ [nucleoplasm] (Bos taurus)
AscH- [nucleoplasm]
EGLN3:AscH-:Fe2+ [nucleoplasm] (Bos taurus)
AscH- [nucleoplasm]
Nuclear PHD1,3 hydroxylates proline residues on HIF3A (Bos taurus)
PHD1,3 [nucleoplasm] (Bos taurus)
EGLN2:AscH-:Fe2+ [nucleoplasm] (Bos taurus)
AscH- [nucleoplasm]
EGLN3:AscH-:Fe2+ [nucleoplasm] (Bos taurus)
AscH- [nucleoplasm]
Cellular responses to stimuli (Caenorhabditis elegans)
Cellular responses to stress (Caenorhabditis elegans)
Cellular response to hypoxia (Caenorhabditis elegans)
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Caenorhabditis elegans)
Nuclear PHD1,3 hydroxylates proline residues on HIF1A (Caenorhabditis elegans)
PHD1,3 [nucleoplasm] (Caenorhabditis elegans)
EGLN2:AscH-:Fe2+ [nucleoplasm] (Caenorhabditis elegans)
AscH- [nucleoplasm]
EGLN3:AscH-:Fe2+ [nucleoplasm] (Caenorhabditis elegans)
AscH- [nucleoplasm]
Nuclear PHD1,3 hydroxylates proline residues on HIF3A (Caenorhabditis elegans)
PHD1,3 [nucleoplasm] (Caenorhabditis elegans)
EGLN2:AscH-:Fe2+ [nucleoplasm] (Caenorhabditis elegans)
AscH- [nucleoplasm]
EGLN3:AscH-:Fe2+ [nucleoplasm] (Caenorhabditis elegans)
AscH- [nucleoplasm]
Cellular responses to stimuli (Canis familiaris)
Cellular responses to stress (Canis familiaris)
Cellular response to hypoxia (Canis familiaris)
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Canis familiaris)
Nuclear PHD1,3 hydroxylates proline residues on HIF1A (Canis familiaris)
PHD1,3 [nucleoplasm] (Canis familiaris)
EGLN2:AscH-:Fe2+ [nucleoplasm] (Canis familiaris)
AscH- [nucleoplasm]
EGLN3:AscH-:Fe2+ [nucleoplasm] (Canis familiaris)
AscH- [nucleoplasm]
Nuclear PHD1,3 hydroxylates proline residues on HIF3A (Canis familiaris)
PHD1,3 [nucleoplasm] (Canis familiaris)
EGLN2:AscH-:Fe2+ [nucleoplasm] (Canis familiaris)
AscH- [nucleoplasm]
EGLN3:AscH-:Fe2+ [nucleoplasm] (Canis familiaris)
AscH- [nucleoplasm]
Cellular responses to stimuli (Danio rerio)
Cellular responses to stress (Danio rerio)
Cellular response to hypoxia (Danio rerio)
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Danio rerio)
Nuclear PHD1,3 hydroxylates proline residues on HIF1A (Danio rerio)
EGLN2:AscH-:Fe2+ [nucleoplasm] (Danio rerio)
AscH- [nucleoplasm]
Nuclear PHD1,3 hydroxylates proline residues on HIF3A (Danio rerio)
EGLN2:AscH-:Fe2+ [nucleoplasm] (Danio rerio)
AscH- [nucleoplasm]
Cellular responses to stimuli (Drosophila melanogaster)
Cellular responses to stress (Drosophila melanogaster)
Cellular response to hypoxia (Drosophila melanogaster)
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Drosophila melanogaster)
Nuclear PHD1,3 hydroxylates proline residues on HIF1A (Drosophila melanogaster)
PHD1,3 [nucleoplasm] (Drosophila melanogaster)
EGLN2:AscH-:Fe2+ [nucleoplasm] (Drosophila melanogaster)
AscH- [nucleoplasm]
EGLN3:AscH-:Fe2+ [nucleoplasm] (Drosophila melanogaster)
AscH- [nucleoplasm]
Nuclear PHD1,3 hydroxylates proline residues on HIF3A (Drosophila melanogaster)
PHD1,3 [nucleoplasm] (Drosophila melanogaster)
EGLN2:AscH-:Fe2+ [nucleoplasm] (Drosophila melanogaster)
AscH- [nucleoplasm]
EGLN3:AscH-:Fe2+ [nucleoplasm] (Drosophila melanogaster)
AscH- [nucleoplasm]
Cellular responses to stimuli (Gallus gallus)
Cellular responses to stress (Gallus gallus)
Cellular response to hypoxia (Gallus gallus)
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Gallus gallus)
Nuclear PHD1,3 hydroxylates proline residues on HIF1A (Gallus gallus)
EGLN3:AscH-:Fe2+ [nucleoplasm] (Gallus gallus)
AscH- [nucleoplasm]
Nuclear PHD1,3 hydroxylates proline residues on HIF3A (Gallus gallus)
EGLN3:AscH-:Fe2+ [nucleoplasm] (Gallus gallus)
AscH- [nucleoplasm]
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to hypoxia (Homo sapiens)
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Homo sapiens)
Nuclear PHD1,3 hydroxylates proline residues on EPAS1 (HIF2A) (Homo sapiens)
PHD1,3 [nucleoplasm] (Homo sapiens)
EGLN2:AscH-:Fe2+ [nucleoplasm] (Homo sapiens)
AscH- [nucleoplasm]
EGLN3:AscH-:Fe2+ [nucleoplasm] (Homo sapiens)
AscH- [nucleoplasm]
Nuclear PHD1,3 hydroxylates proline residues on HIF1A (Homo sapiens)
PHD1,3 [nucleoplasm] (Homo sapiens)
EGLN2:AscH-:Fe2+ [nucleoplasm] (Homo sapiens)
AscH- [nucleoplasm]
EGLN3:AscH-:Fe2+ [nucleoplasm] (Homo sapiens)
AscH- [nucleoplasm]
Nuclear PHD1,3 hydroxylates proline residues on HIF3A (Homo sapiens)
PHD1,3 [nucleoplasm] (Homo sapiens)
EGLN2:AscH-:Fe2+ [nucleoplasm] (Homo sapiens)
AscH- [nucleoplasm]
EGLN3:AscH-:Fe2+ [nucleoplasm] (Homo sapiens)
AscH- [nucleoplasm]
Gene expression (Transcription) (Homo sapiens)
Epigenetic regulation of gene expression (Homo sapiens)
TET1,2,3 and TDG demethylate DNA (Homo sapiens)
TET1,2,3 oxidizes 5-methylcytosine to 5-hydroxymethylcytosine (Homo sapiens)
AscH- [nucleoplasm]
Cellular responses to stimuli (Mus musculus)
Cellular responses to stress (Mus musculus)
Cellular response to hypoxia (Mus musculus)
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Mus musculus)
Nuclear PHD1,3 hydroxylates proline residues on HIF1A (Mus musculus)
PHD1,3 [nucleoplasm] (Mus musculus)
EGLN2:AscH-:Fe2+ [nucleoplasm] (Mus musculus)
AscH- [nucleoplasm]
EGLN3:AscH-:Fe2+ [nucleoplasm] (Mus musculus)
AscH- [nucleoplasm]
Nuclear PHD1,3 hydroxylates proline residues on HIF3A (Mus musculus)
PHD1,3 [nucleoplasm] (Mus musculus)
EGLN2:AscH-:Fe2+ [nucleoplasm] (Mus musculus)
AscH- [nucleoplasm]
EGLN3:AscH-:Fe2+ [nucleoplasm] (Mus musculus)
AscH- [nucleoplasm]
Cellular responses to stimuli (Rattus norvegicus)
Cellular responses to stress (Rattus norvegicus)
Cellular response to hypoxia (Rattus norvegicus)
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Rattus norvegicus)
Nuclear PHD1,3 hydroxylates proline residues on HIF1A (Rattus norvegicus)
PHD1,3 [nucleoplasm] (Rattus norvegicus)
EGLN2:AscH-:Fe2+ [nucleoplasm] (Rattus norvegicus)
AscH- [nucleoplasm]
EGLN3:AscH-:Fe2+ [nucleoplasm] (Rattus norvegicus)
AscH- [nucleoplasm]
Nuclear PHD1,3 hydroxylates proline residues on HIF3A (Rattus norvegicus)
PHD1,3 [nucleoplasm] (Rattus norvegicus)
EGLN2:AscH-:Fe2+ [nucleoplasm] (Rattus norvegicus)
AscH- [nucleoplasm]
EGLN3:AscH-:Fe2+ [nucleoplasm] (Rattus norvegicus)
AscH- [nucleoplasm]
Cellular responses to stimuli (Sus scrofa)
Cellular responses to stress (Sus scrofa)
Cellular response to hypoxia (Sus scrofa)
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Sus scrofa)
Nuclear PHD1,3 hydroxylates proline residues on HIF1A (Sus scrofa)
EGLN3:AscH-:Fe2+ [nucleoplasm] (Sus scrofa)
AscH- [nucleoplasm]
Nuclear PHD1,3 hydroxylates proline residues on HIF3A (Sus scrofa)
EGLN3:AscH-:Fe2+ [nucleoplasm] (Sus scrofa)
AscH- [nucleoplasm]
Cellular responses to stimuli (Xenopus tropicalis)
Cellular responses to stress (Xenopus tropicalis)
Cellular response to hypoxia (Xenopus tropicalis)
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha (Xenopus tropicalis)
Nuclear PHD1,3 hydroxylates proline residues on HIF1A (Xenopus tropicalis)
PHD1,3 [nucleoplasm] (Xenopus tropicalis)
EGLN2:AscH-:Fe2+ [nucleoplasm] (Xenopus tropicalis)
AscH- [nucleoplasm]
EGLN3:AscH-:Fe2+ [nucleoplasm] (Xenopus tropicalis)
AscH- [nucleoplasm]
Nuclear PHD1,3 hydroxylates proline residues on HIF3A (Xenopus tropicalis)
PHD1,3 [nucleoplasm] (Xenopus tropicalis)
EGLN2:AscH-:Fe2+ [nucleoplasm] (Xenopus tropicalis)
AscH- [nucleoplasm]
EGLN3:AscH-:Fe2+ [nucleoplasm] (Xenopus tropicalis)
AscH- [nucleoplasm]
External Reference Information
External Reference
L-ascorbate [ChEBI:38290]
Participates
as a component of
EGLN2:AscH-:Fe2+ [nucleoplasm] (Canis familiaris)
EGLN2:AscH-:Fe2+ [nucleoplasm] (Xenopus tropicalis)
EGLN2:AscH-:Fe2+ [nucleoplasm] (Drosophila melanogaster)
EGLN2:AscH-:Fe2+ [nucleoplasm] (Bos taurus)
EGLN2:AscH-:Fe2+ [nucleoplasm] (Caenorhabditis elegans)
EGLN2:AscH-:Fe2+ [nucleoplasm] (Mus musculus)
EGLN2:AscH-:Fe2+ [nucleoplasm] (Rattus norvegicus)
EGLN2:AscH-:Fe2+ [nucleoplasm] (Homo sapiens)
EGLN3:AscH-:Fe2+ [nucleoplasm] (Rattus norvegicus)
EGLN3:AscH-:Fe2+ [nucleoplasm] (Drosophila melanogaster)
EGLN3:AscH-:Fe2+ [nucleoplasm] (Caenorhabditis elegans)
EGLN3:AscH-:Fe2+ [nucleoplasm] (Sus scrofa)
EGLN3:AscH-:Fe2+ [nucleoplasm] (Xenopus tropicalis)
EGLN3:AscH-:Fe2+ [nucleoplasm] (Bos taurus)
EGLN3:AscH-:Fe2+ [nucleoplasm] (Canis familiaris)
EGLN3:AscH-:Fe2+ [nucleoplasm] (Mus musculus)
EGLN3:AscH-:Fe2+ [nucleoplasm] (Gallus gallus)
EGLN3:AscH-:Fe2+ [nucleoplasm] (Homo sapiens)
EGLN2:AscH-:Fe2+ [nucleoplasm] (Danio rerio)
This entity regulates
Positively
Tet1,2,3 oxidizes 5-methylcytosine to 5-hydroxymethylcytosine
(Mus musculus)
TET1,2,3 oxidizes 5-methylcytosine to 5-hydroxymethylcytosine
(Homo sapiens)
Other forms of this molecule
AscH- [extracellular region]
AscH- [secretory granule lumen]
AscH- [cytosol]
Cross References
AraCyc
ASCORBATE
CAS
50-81-7
COMPOUND
C00072
PubChem Compound
44229109
ZINC
ZINC000100006770
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![AscH- [nucleoplasm] icon](/icon/R-ICO-013873.svg){kind=icon}
