mRNA Transcript Targeted by HuR Phosphorylated on Ser221 and Ser318 [cytosol]

Stable Identifier
R-ALL-517560
Type
OtherEntity
Compartment
cytosol
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General
Phosphorylated HuR (phosphoserine221 and phosphoserine318) binds AU-rich elements in the following mRNAs: Cyclooxygenase-2 (COX-2, PTGS2), Cyclin A (CCNA, CCNA2), and Cyclin D1 (CCND1).
Literature References
PubMed ID Title Journal Year
20086103 Tandem phosphorylation of serine 221 and 318 by PKC{delta} coordinates mRNA binding and nucleo-cytoplasmic shuttling of HuR

Doller, A, Schlepckow, K, Schwalbe, H, Pfeilschifter, J, Eberhardt, W

Mol Cell Biol 2010
18285462 Posttranslational modification of the AU-rich element binding protein HuR by protein kinase Cdelta elicits angiotensin II-induced stabilization and nuclear export of cyclooxygenase 2 mRNA

Doller, A, Akool, el-S, Huwiler, A, Müller, R, Radeke, HH, Pfeilschifter, J, Eberhardt, W

Mol Cell Biol 2008
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