BEZ235 [cytosol]

Stable Identifier
R-ALL-2399744
Type
ChemicalDrug
Compartment
cytosol
Synonyms
NVP-BEZ235, dactolisib
Locations in the PathwayBrowser
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Literature References
PubMed ID Title Journal Year
18606717 Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity

Furet, P, De Pover, A, Brachmann, S, Finan, P, Chène, P, Fabbro, D, García-Echeverría, C, Maira, SM, Murphy, L, Gabriel, D, Schnell, C, Schoemaker, K, Fritsch, C, Brueggen, J, Simonen, M, Sellers, W, Stauffer, F

Mol. Cancer Ther. 2008
18829560 NVP-BEZ235, a dual PI3K/mTOR inhibitor, prevents PI3K signaling and inhibits the growth of cancer cells with activating PI3K mutations

Arribas, J, Maira, M, Baselga, J, Guzman, M, Parra, JL, Eichhorn, PJ, Atzori, F, Botero, ML, Serra, V, Valero, V, Markman, B, Di Cosimo, S, Llonch, E, Garcia-Echeverria, C, Scaltriti, M

Cancer Res. 2008
External Reference Information
External Reference
dactolisib [Guide to Pharmacology:7950]
Participates
as a member of
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Cross References
ChEBI
PharmacoDB
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