Reactome | MHC class II epitopes [plasma membrane]

MHC class II epitopes [plasma membrane]

Stable Identifier

R-ALL-2213228

Type

OtherEntity

Compartment

plasma membrane

Locations in the PathwayBrowser

for Species:

Expand all

Immune System (Bos taurus)

- Adaptive Immune System (Bos taurus)
  - MHC class II antigen presentation (Bos taurus)
    - Transport of antigen loaded MHC II molecules to surface (Bos taurus)
      - MHC Class II bearing antigen peptide [plasma membrane] (Bos taurus)
        
        MHC class II epitopes [plasma membrane]
  - Regulation of T cell activation by CD28 family (Bos taurus)
    - Co-inhibition by PD-1 (Bos taurus)
      - Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Bos taurus)
        
        Antigen-bearing MHC Class II: TCR with dephosphorylated CD3 zeta chain:CD4 [plasma membrane] (Bos taurus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Bos taurus)
        
        MHC class II epitopes [plasma membrane]
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Bos taurus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Bos taurus)
        
        MHC class II epitopes [plasma membrane]
  - TCR signaling (Bos taurus)
    - Downstream TCR signaling (Bos taurus)
      - Change of PKC theta conformation (Bos taurus)
        
        Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Bos taurus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Bos taurus)
        
        MHC class II epitopes [plasma membrane]
    - Generation of second messenger molecules (Bos taurus)
      - Phosphorylation of PLC-gamma1 (Bos taurus)
        
        ZAP-70 and ITK tyrosine kinases [plasma membrane] (Bos taurus)
        
        Activated ZAP-70 [plasma membrane] (Bos taurus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Bos taurus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Bos taurus)
        
        MHC class II epitopes [plasma membrane]
      - Phosphorylation of SLP-76 (Bos taurus)
        
        Activated ZAP-70 [plasma membrane] (Bos taurus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Bos taurus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Bos taurus)
        
        MHC class II epitopes [plasma membrane]
      - Phosphorylation of TBSMs in LAT (Bos taurus)
        
        Activated ZAP-70 [plasma membrane] (Bos taurus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Bos taurus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Bos taurus)
        
        MHC class II epitopes [plasma membrane]
    - Phosphorylation of CD3 and TCR zeta chains (Bos taurus)
      - Activation of Lck (Bos taurus)
        
        Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] (Bos taurus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Bos taurus)
        
        MHC class II epitopes [plasma membrane]
        
        Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Bos taurus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Bos taurus)
        
        MHC class II epitopes [plasma membrane]
      - Dephosphorylation of Lck-pY505 by CD45 (Bos taurus)
        
        Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] (Bos taurus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Bos taurus)
        
        MHC class II epitopes [plasma membrane]
        
        Antigen-bearing MHC Class II : TCR complex:CD4:p-Lck(Y505) [plasma membrane] (Bos taurus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Bos taurus)
        
        MHC class II epitopes [plasma membrane]
      - Inactivation of LCK by PTPN22 (Bos taurus)
        
        Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] (Bos taurus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Bos taurus)
        
        MHC class II epitopes [plasma membrane]
        
        Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Bos taurus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Bos taurus)
        
        MHC class II epitopes [plasma membrane]
      - Inactivation of Lck by Csk (Bos taurus)
        
        Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] (Bos taurus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Bos taurus)
        
        MHC class II epitopes [plasma membrane]
        
        Antigen-bearing MHC Class II : TCR complex:CD4:p-Lck(Y505) [plasma membrane] (Bos taurus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Bos taurus)
        
        MHC class II epitopes [plasma membrane]
      - Phosphorylation of ITAM motifs in CD3 complexes (Bos taurus)
        
        Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Bos taurus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Bos taurus)
        
        MHC class II epitopes [plasma membrane]
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Bos taurus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Bos taurus)
        
        MHC class II epitopes [plasma membrane]
    - Translocation of ZAP-70 to Immunological synapse (Bos taurus)
      - Activation of ZAP-70 (Bos taurus)
        
        Activated ZAP-70 [plasma membrane] (Bos taurus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Bos taurus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Bos taurus)
        
        MHC class II epitopes [plasma membrane]
        
        phospho tyrosine ZAP-70 [plasma membrane] (Bos taurus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Bos taurus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Bos taurus)
        
        MHC class II epitopes [plasma membrane]
      - PTPN22 dephosphorylates ZAP70 (Bos taurus)
        
        ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] (Bos taurus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Bos taurus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Bos taurus)
        
        MHC class II epitopes [plasma membrane]
        
        phospho tyrosine ZAP-70 [plasma membrane] (Bos taurus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Bos taurus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Bos taurus)
        
        MHC class II epitopes [plasma membrane]
      - Phosphorylation of ZAP-70 by Lck (Bos taurus)
        
        Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Bos taurus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Bos taurus)
        
        MHC class II epitopes [plasma membrane]
        
        ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] (Bos taurus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Bos taurus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Bos taurus)
        
        MHC class II epitopes [plasma membrane]
        
        phospho tyrosine ZAP-70 [plasma membrane] (Bos taurus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Bos taurus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Bos taurus)
        
        MHC class II epitopes [plasma membrane]
      - Recruitment of ZAP-70 to phosphorylated ITAMs (Bos taurus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Bos taurus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Bos taurus)
        
        MHC class II epitopes [plasma membrane]
        
        ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] (Bos taurus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Bos taurus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Bos taurus)
        
        MHC class II epitopes [plasma membrane]

Immune System (Canis familiaris)

- Adaptive Immune System (Canis familiaris)
  - MHC class II antigen presentation (Canis familiaris)
    - Transport of antigen loaded MHC II molecules to surface (Canis familiaris)
      - MHC Class II bearing antigen peptide [plasma membrane] (Canis familiaris)
        
        MHC class II epitopes [plasma membrane]
  - Regulation of T cell activation by CD28 family (Canis familiaris)
    - Co-inhibition by PD-1 (Canis familiaris)
      - Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Canis familiaris)
        
        Antigen-bearing MHC Class II: TCR with dephosphorylated CD3 zeta chain:CD4 [plasma membrane] (Canis familiaris)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Canis familiaris)
        
        MHC class II epitopes [plasma membrane]
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Canis familiaris)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Canis familiaris)
        
        MHC class II epitopes [plasma membrane]
  - TCR signaling (Canis familiaris)
    - Downstream TCR signaling (Canis familiaris)
      - Change of PKC theta conformation (Canis familiaris)
        
        Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Canis familiaris)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Canis familiaris)
        
        MHC class II epitopes [plasma membrane]
    - Generation of second messenger molecules (Canis familiaris)
      - Phosphorylation of PLC-gamma1 (Canis familiaris)
        
        ZAP-70 and ITK tyrosine kinases [plasma membrane] (Canis familiaris)
        
        Activated ZAP-70 [plasma membrane] (Canis familiaris)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Canis familiaris)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Canis familiaris)
        
        MHC class II epitopes [plasma membrane]
      - Phosphorylation of SLP-76 (Canis familiaris)
        
        Activated ZAP-70 [plasma membrane] (Canis familiaris)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Canis familiaris)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Canis familiaris)
        
        MHC class II epitopes [plasma membrane]
      - Phosphorylation of TBSMs in LAT (Canis familiaris)
        
        Activated ZAP-70 [plasma membrane] (Canis familiaris)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Canis familiaris)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Canis familiaris)
        
        MHC class II epitopes [plasma membrane]
    - Phosphorylation of CD3 and TCR zeta chains (Canis familiaris)
      - Activation of Lck (Canis familiaris)
        
        Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] (Canis familiaris)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Canis familiaris)
        
        MHC class II epitopes [plasma membrane]
        
        Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Canis familiaris)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Canis familiaris)
        
        MHC class II epitopes [plasma membrane]
      - Dephosphorylation of Lck-pY505 by CD45 (Canis familiaris)
        
        Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] (Canis familiaris)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Canis familiaris)
        
        MHC class II epitopes [plasma membrane]
        
        Antigen-bearing MHC Class II : TCR complex:CD4:p-Lck(Y505) [plasma membrane] (Canis familiaris)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Canis familiaris)
        
        MHC class II epitopes [plasma membrane]
      - Inactivation of LCK by PTPN22 (Canis familiaris)
        
        Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] (Canis familiaris)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Canis familiaris)
        
        MHC class II epitopes [plasma membrane]
        
        Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Canis familiaris)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Canis familiaris)
        
        MHC class II epitopes [plasma membrane]
      - Inactivation of Lck by Csk (Canis familiaris)
        
        Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] (Canis familiaris)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Canis familiaris)
        
        MHC class II epitopes [plasma membrane]
        
        Antigen-bearing MHC Class II : TCR complex:CD4:p-Lck(Y505) [plasma membrane] (Canis familiaris)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Canis familiaris)
        
        MHC class II epitopes [plasma membrane]
      - Phosphorylation of ITAM motifs in CD3 complexes (Canis familiaris)
        
        Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Canis familiaris)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Canis familiaris)
        
        MHC class II epitopes [plasma membrane]
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Canis familiaris)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Canis familiaris)
        
        MHC class II epitopes [plasma membrane]
    - Translocation of ZAP-70 to Immunological synapse (Canis familiaris)
      - Activation of ZAP-70 (Canis familiaris)
        
        Activated ZAP-70 [plasma membrane] (Canis familiaris)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Canis familiaris)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Canis familiaris)
        
        MHC class II epitopes [plasma membrane]
        
        phospho tyrosine ZAP-70 [plasma membrane] (Canis familiaris)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Canis familiaris)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Canis familiaris)
        
        MHC class II epitopes [plasma membrane]
      - PTPN22 dephosphorylates ZAP70 (Canis familiaris)
        
        ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] (Canis familiaris)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Canis familiaris)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Canis familiaris)
        
        MHC class II epitopes [plasma membrane]
        
        phospho tyrosine ZAP-70 [plasma membrane] (Canis familiaris)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Canis familiaris)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Canis familiaris)
        
        MHC class II epitopes [plasma membrane]
      - Phosphorylation of ZAP-70 by Lck (Canis familiaris)
        
        Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Canis familiaris)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Canis familiaris)
        
        MHC class II epitopes [plasma membrane]
        
        ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] (Canis familiaris)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Canis familiaris)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Canis familiaris)
        
        MHC class II epitopes [plasma membrane]
        
        phospho tyrosine ZAP-70 [plasma membrane] (Canis familiaris)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Canis familiaris)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Canis familiaris)
        
        MHC class II epitopes [plasma membrane]
      - Recruitment of ZAP-70 to phosphorylated ITAMs (Canis familiaris)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Canis familiaris)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Canis familiaris)
        
        MHC class II epitopes [plasma membrane]
        
        ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] (Canis familiaris)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Canis familiaris)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Canis familiaris)
        
        MHC class II epitopes [plasma membrane]

Immune System (Homo sapiens)

- Adaptive Immune System (Homo sapiens)
  - MHC class II antigen presentation (Homo sapiens)
    - Transport of antigen loaded MHC II molecules to surface (Homo sapiens)
      - MHC Class II bearing antigen peptide [plasma membrane] (Homo sapiens)
        
        MHC class II epitopes [plasma membrane]
  - Regulation of T cell activation by CD28 family (Homo sapiens)
    - Co-inhibition by PD-1 (Homo sapiens)
      - Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Homo sapiens)
        
        Antigen-bearing MHC Class II: TCR with dephosphorylated CD3 zeta chain:CD4 [plasma membrane] (Homo sapiens)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Homo sapiens)
        
        MHC class II epitopes [plasma membrane]
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Homo sapiens)
        
        MHC class II epitopes [plasma membrane]
  - TCR signaling (Homo sapiens)
    - Downstream TCR signaling (Homo sapiens)
      - Change of PKC theta conformation (Homo sapiens)
        
        Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Homo sapiens)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Homo sapiens)
        
        MHC class II epitopes [plasma membrane]
    - Generation of second messenger molecules (Homo sapiens)
      - Phosphorylation of PLC-gamma1 (Homo sapiens)
        
        ZAP-70 and ITK tyrosine kinases [plasma membrane] (Homo sapiens)
        
        Activated ZAP-70 [plasma membrane] (Homo sapiens)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Homo sapiens)
        
        MHC class II epitopes [plasma membrane]
      - Phosphorylation of SLP-76 (Homo sapiens)
        
        Activated ZAP-70 [plasma membrane] (Homo sapiens)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Homo sapiens)
        
        MHC class II epitopes [plasma membrane]
      - Phosphorylation of TBSMs in LAT (Homo sapiens)
        
        Activated ZAP-70 [plasma membrane] (Homo sapiens)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Homo sapiens)
        
        MHC class II epitopes [plasma membrane]
    - Phosphorylation of CD3 and TCR zeta chains (Homo sapiens)
      - Activation of Lck (Homo sapiens)
        
        Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] (Homo sapiens)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Homo sapiens)
        
        MHC class II epitopes [plasma membrane]
        
        Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Homo sapiens)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Homo sapiens)
        
        MHC class II epitopes [plasma membrane]
      - Dephosphorylation of Lck-pY505 by CD45 (Homo sapiens)
        
        Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] (Homo sapiens)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Homo sapiens)
        
        MHC class II epitopes [plasma membrane]
        
        Antigen-bearing MHC Class II : TCR complex:CD4:p-Lck(Y505) [plasma membrane] (Homo sapiens)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Homo sapiens)
        
        MHC class II epitopes [plasma membrane]
      - Inactivation of LCK by PTPN22 (Homo sapiens)
        
        Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] (Homo sapiens)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Homo sapiens)
        
        MHC class II epitopes [plasma membrane]
        
        Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Homo sapiens)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Homo sapiens)
        
        MHC class II epitopes [plasma membrane]
      - Inactivation of Lck by Csk (Homo sapiens)
        
        Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] (Homo sapiens)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Homo sapiens)
        
        MHC class II epitopes [plasma membrane]
        
        Antigen-bearing MHC Class II : TCR complex:CD4:p-Lck(Y505) [plasma membrane] (Homo sapiens)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Homo sapiens)
        
        MHC class II epitopes [plasma membrane]
      - Phosphorylation of ITAM motifs in CD3 complexes (Homo sapiens)
        
        Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Homo sapiens)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Homo sapiens)
        
        MHC class II epitopes [plasma membrane]
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Homo sapiens)
        
        MHC class II epitopes [plasma membrane]
    - Translocation of ZAP-70 to Immunological synapse (Homo sapiens)
      - Activation of ZAP-70 (Homo sapiens)
        
        Activated ZAP-70 [plasma membrane] (Homo sapiens)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Homo sapiens)
        
        MHC class II epitopes [plasma membrane]
        
        phospho tyrosine ZAP-70 [plasma membrane] (Homo sapiens)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Homo sapiens)
        
        MHC class II epitopes [plasma membrane]
      - PTPN22 dephosphorylates ZAP70 (Homo sapiens)
        
        ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] (Homo sapiens)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Homo sapiens)
        
        MHC class II epitopes [plasma membrane]
        
        phospho tyrosine ZAP-70 [plasma membrane] (Homo sapiens)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Homo sapiens)
        
        MHC class II epitopes [plasma membrane]
      - Phosphorylation of ZAP-70 by Lck (Homo sapiens)
        
        Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Homo sapiens)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Homo sapiens)
        
        MHC class II epitopes [plasma membrane]
        
        ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] (Homo sapiens)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Homo sapiens)
        
        MHC class II epitopes [plasma membrane]
        
        phospho tyrosine ZAP-70 [plasma membrane] (Homo sapiens)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Homo sapiens)
        
        MHC class II epitopes [plasma membrane]
      - Recruitment of ZAP-70 to phosphorylated ITAMs (Homo sapiens)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Homo sapiens)
        
        MHC class II epitopes [plasma membrane]
        
        ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] (Homo sapiens)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Homo sapiens)
        
        MHC class II epitopes [plasma membrane]

Immune System (Mus musculus)

- Adaptive Immune System (Mus musculus)
  - MHC class II antigen presentation (Mus musculus)
    - Transport of antigen loaded MHC II molecules to surface (Mus musculus)
      - MHC Class II bearing antigen peptide [plasma membrane] (Mus musculus)
        
        MHC class II epitopes [plasma membrane]
  - Regulation of T cell activation by CD28 family (Mus musculus)
    - Co-inhibition by PD-1 (Mus musculus)
      - Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Mus musculus)
        
        Antigen-bearing MHC Class II: TCR with dephosphorylated CD3 zeta chain:CD4 [plasma membrane] (Mus musculus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Mus musculus)
        
        MHC class II epitopes [plasma membrane]
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Mus musculus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Mus musculus)
        
        MHC class II epitopes [plasma membrane]
  - TCR signaling (Mus musculus)
    - Downstream TCR signaling (Mus musculus)
      - Change of PKC theta conformation (Mus musculus)
        
        Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Mus musculus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Mus musculus)
        
        MHC class II epitopes [plasma membrane]
    - Generation of second messenger molecules (Mus musculus)
      - Phosphorylation of PLC-gamma1 (Mus musculus)
        
        ZAP-70 and ITK tyrosine kinases [plasma membrane] (Mus musculus)
        
        Activated ZAP-70 [plasma membrane] (Mus musculus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Mus musculus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Mus musculus)
        
        MHC class II epitopes [plasma membrane]
      - Phosphorylation of SLP-76 (Mus musculus)
        
        Activated ZAP-70 [plasma membrane] (Mus musculus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Mus musculus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Mus musculus)
        
        MHC class II epitopes [plasma membrane]
      - Phosphorylation of TBSMs in LAT (Mus musculus)
        
        Activated ZAP-70 [plasma membrane] (Mus musculus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Mus musculus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Mus musculus)
        
        MHC class II epitopes [plasma membrane]
    - Phosphorylation of CD3 and TCR zeta chains (Mus musculus)
      - Activation of Lck (Mus musculus)
        
        Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] (Mus musculus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Mus musculus)
        
        MHC class II epitopes [plasma membrane]
        
        Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Mus musculus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Mus musculus)
        
        MHC class II epitopes [plasma membrane]
      - Dephosphorylation of Lck-pY505 by CD45 (Mus musculus)
        
        Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] (Mus musculus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Mus musculus)
        
        MHC class II epitopes [plasma membrane]
        
        Antigen-bearing MHC Class II : TCR complex:CD4:p-Lck(Y505) [plasma membrane] (Mus musculus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Mus musculus)
        
        MHC class II epitopes [plasma membrane]
      - Inactivation of LCK by PTPN22 (Mus musculus)
        
        Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] (Mus musculus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Mus musculus)
        
        MHC class II epitopes [plasma membrane]
        
        Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Mus musculus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Mus musculus)
        
        MHC class II epitopes [plasma membrane]
      - Inactivation of Lck by Csk (Mus musculus)
        
        Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] (Mus musculus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Mus musculus)
        
        MHC class II epitopes [plasma membrane]
        
        Antigen-bearing MHC Class II : TCR complex:CD4:p-Lck(Y505) [plasma membrane] (Mus musculus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Mus musculus)
        
        MHC class II epitopes [plasma membrane]
      - Phosphorylation of ITAM motifs in CD3 complexes (Mus musculus)
        
        Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Mus musculus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Mus musculus)
        
        MHC class II epitopes [plasma membrane]
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Mus musculus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Mus musculus)
        
        MHC class II epitopes [plasma membrane]
    - Translocation of ZAP-70 to Immunological synapse (Mus musculus)
      - Activation of ZAP-70 (Mus musculus)
        
        Activated ZAP-70 [plasma membrane] (Mus musculus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Mus musculus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Mus musculus)
        
        MHC class II epitopes [plasma membrane]
        
        phospho tyrosine ZAP-70 [plasma membrane] (Mus musculus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Mus musculus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Mus musculus)
        
        MHC class II epitopes [plasma membrane]
      - PTPN22 dephosphorylates ZAP70 (Mus musculus)
        
        ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] (Mus musculus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Mus musculus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Mus musculus)
        
        MHC class II epitopes [plasma membrane]
        
        phospho tyrosine ZAP-70 [plasma membrane] (Mus musculus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Mus musculus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Mus musculus)
        
        MHC class II epitopes [plasma membrane]
      - Phosphorylation of ZAP-70 by Lck (Mus musculus)
        
        Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Mus musculus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Mus musculus)
        
        MHC class II epitopes [plasma membrane]
        
        ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] (Mus musculus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Mus musculus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Mus musculus)
        
        MHC class II epitopes [plasma membrane]
        
        phospho tyrosine ZAP-70 [plasma membrane] (Mus musculus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Mus musculus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Mus musculus)
        
        MHC class II epitopes [plasma membrane]
      - Recruitment of ZAP-70 to phosphorylated ITAMs (Mus musculus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Mus musculus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Mus musculus)
        
        MHC class II epitopes [plasma membrane]
        
        ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] (Mus musculus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Mus musculus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Mus musculus)
        
        MHC class II epitopes [plasma membrane]

Immune System (Rattus norvegicus)

- Adaptive Immune System (Rattus norvegicus)
  - MHC class II antigen presentation (Rattus norvegicus)
    - Transport of antigen loaded MHC II molecules to surface (Rattus norvegicus)
      - MHC Class II bearing antigen peptide [plasma membrane] (Rattus norvegicus)
        
        MHC class II epitopes [plasma membrane]
  - Regulation of T cell activation by CD28 family (Rattus norvegicus)
    - Co-inhibition by PD-1 (Rattus norvegicus)
      - Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Rattus norvegicus)
        
        Antigen-bearing MHC Class II: TCR with dephosphorylated CD3 zeta chain:CD4 [plasma membrane] (Rattus norvegicus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Rattus norvegicus)
        
        MHC class II epitopes [plasma membrane]
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Rattus norvegicus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Rattus norvegicus)
        
        MHC class II epitopes [plasma membrane]
  - TCR signaling (Rattus norvegicus)
    - Downstream TCR signaling (Rattus norvegicus)
      - Change of PKC theta conformation (Rattus norvegicus)
        
        Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Rattus norvegicus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Rattus norvegicus)
        
        MHC class II epitopes [plasma membrane]
    - Generation of second messenger molecules (Rattus norvegicus)
      - Phosphorylation of PLC-gamma1 (Rattus norvegicus)
        
        ZAP-70 and ITK tyrosine kinases [plasma membrane] (Rattus norvegicus)
        
        Activated ZAP-70 [plasma membrane] (Rattus norvegicus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Rattus norvegicus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Rattus norvegicus)
        
        MHC class II epitopes [plasma membrane]
      - Phosphorylation of SLP-76 (Rattus norvegicus)
        
        Activated ZAP-70 [plasma membrane] (Rattus norvegicus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Rattus norvegicus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Rattus norvegicus)
        
        MHC class II epitopes [plasma membrane]
      - Phosphorylation of TBSMs in LAT (Rattus norvegicus)
        
        Activated ZAP-70 [plasma membrane] (Rattus norvegicus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Rattus norvegicus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Rattus norvegicus)
        
        MHC class II epitopes [plasma membrane]
    - Phosphorylation of CD3 and TCR zeta chains (Rattus norvegicus)
      - Activation of Lck (Rattus norvegicus)
        
        Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] (Rattus norvegicus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Rattus norvegicus)
        
        MHC class II epitopes [plasma membrane]
        
        Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Rattus norvegicus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Rattus norvegicus)
        
        MHC class II epitopes [plasma membrane]
      - Dephosphorylation of Lck-pY505 by CD45 (Rattus norvegicus)
        
        Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] (Rattus norvegicus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Rattus norvegicus)
        
        MHC class II epitopes [plasma membrane]
        
        Antigen-bearing MHC Class II : TCR complex:CD4:p-Lck(Y505) [plasma membrane] (Rattus norvegicus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Rattus norvegicus)
        
        MHC class II epitopes [plasma membrane]
      - Inactivation of LCK by PTPN22 (Rattus norvegicus)
        
        Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] (Rattus norvegicus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Rattus norvegicus)
        
        MHC class II epitopes [plasma membrane]
        
        Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Rattus norvegicus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Rattus norvegicus)
        
        MHC class II epitopes [plasma membrane]
      - Inactivation of Lck by Csk (Rattus norvegicus)
        
        Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] (Rattus norvegicus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Rattus norvegicus)
        
        MHC class II epitopes [plasma membrane]
        
        Antigen-bearing MHC Class II : TCR complex:CD4:p-Lck(Y505) [plasma membrane] (Rattus norvegicus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Rattus norvegicus)
        
        MHC class II epitopes [plasma membrane]
      - Phosphorylation of ITAM motifs in CD3 complexes (Rattus norvegicus)
        
        Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Rattus norvegicus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Rattus norvegicus)
        
        MHC class II epitopes [plasma membrane]
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Rattus norvegicus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Rattus norvegicus)
        
        MHC class II epitopes [plasma membrane]
    - Translocation of ZAP-70 to Immunological synapse (Rattus norvegicus)
      - Activation of ZAP-70 (Rattus norvegicus)
        
        Activated ZAP-70 [plasma membrane] (Rattus norvegicus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Rattus norvegicus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Rattus norvegicus)
        
        MHC class II epitopes [plasma membrane]
        
        phospho tyrosine ZAP-70 [plasma membrane] (Rattus norvegicus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Rattus norvegicus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Rattus norvegicus)
        
        MHC class II epitopes [plasma membrane]
      - PTPN22 dephosphorylates ZAP70 (Rattus norvegicus)
        
        ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] (Rattus norvegicus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Rattus norvegicus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Rattus norvegicus)
        
        MHC class II epitopes [plasma membrane]
        
        phospho tyrosine ZAP-70 [plasma membrane] (Rattus norvegicus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Rattus norvegicus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Rattus norvegicus)
        
        MHC class II epitopes [plasma membrane]
      - Phosphorylation of ZAP-70 by Lck (Rattus norvegicus)
        
        Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Rattus norvegicus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Rattus norvegicus)
        
        MHC class II epitopes [plasma membrane]
        
        ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] (Rattus norvegicus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Rattus norvegicus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Rattus norvegicus)
        
        MHC class II epitopes [plasma membrane]
        
        phospho tyrosine ZAP-70 [plasma membrane] (Rattus norvegicus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Rattus norvegicus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Rattus norvegicus)
        
        MHC class II epitopes [plasma membrane]
      - Recruitment of ZAP-70 to phosphorylated ITAMs (Rattus norvegicus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Rattus norvegicus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Rattus norvegicus)
        
        MHC class II epitopes [plasma membrane]
        
        ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] (Rattus norvegicus)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Rattus norvegicus)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Rattus norvegicus)
        
        MHC class II epitopes [plasma membrane]

Immune System (Sus scrofa)

- Adaptive Immune System (Sus scrofa)
  - MHC class II antigen presentation (Sus scrofa)
    - Transport of antigen loaded MHC II molecules to surface (Sus scrofa)
      - MHC Class II bearing antigen peptide [plasma membrane] (Sus scrofa)
        
        MHC class II epitopes [plasma membrane]
  - Regulation of T cell activation by CD28 family (Sus scrofa)
    - Co-inhibition by PD-1 (Sus scrofa)
      - Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Sus scrofa)
        
        Antigen-bearing MHC Class II: TCR with dephosphorylated CD3 zeta chain:CD4 [plasma membrane] (Sus scrofa)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Sus scrofa)
        
        MHC class II epitopes [plasma membrane]
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Sus scrofa)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Sus scrofa)
        
        MHC class II epitopes [plasma membrane]
  - TCR signaling (Sus scrofa)
    - Downstream TCR signaling (Sus scrofa)
      - Change of PKC theta conformation (Sus scrofa)
        
        Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Sus scrofa)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Sus scrofa)
        
        MHC class II epitopes [plasma membrane]
    - Generation of second messenger molecules (Sus scrofa)
      - Phosphorylation of PLC-gamma1 (Sus scrofa)
        
        ZAP-70 and ITK tyrosine kinases [plasma membrane] (Sus scrofa)
        
        Activated ZAP-70 [plasma membrane] (Sus scrofa)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Sus scrofa)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Sus scrofa)
        
        MHC class II epitopes [plasma membrane]
      - Phosphorylation of SLP-76 (Sus scrofa)
        
        Activated ZAP-70 [plasma membrane] (Sus scrofa)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Sus scrofa)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Sus scrofa)
        
        MHC class II epitopes [plasma membrane]
      - Phosphorylation of TBSMs in LAT (Sus scrofa)
        
        Activated ZAP-70 [plasma membrane] (Sus scrofa)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Sus scrofa)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Sus scrofa)
        
        MHC class II epitopes [plasma membrane]
    - Phosphorylation of CD3 and TCR zeta chains (Sus scrofa)
      - Activation of Lck (Sus scrofa)
        
        Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] (Sus scrofa)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Sus scrofa)
        
        MHC class II epitopes [plasma membrane]
        
        Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Sus scrofa)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Sus scrofa)
        
        MHC class II epitopes [plasma membrane]
      - Dephosphorylation of Lck-pY505 by CD45 (Sus scrofa)
        
        Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] (Sus scrofa)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Sus scrofa)
        
        MHC class II epitopes [plasma membrane]
        
        Antigen-bearing MHC Class II : TCR complex:CD4:p-Lck(Y505) [plasma membrane] (Sus scrofa)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Sus scrofa)
        
        MHC class II epitopes [plasma membrane]
      - Inactivation of LCK by PTPN22 (Sus scrofa)
        
        Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] (Sus scrofa)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Sus scrofa)
        
        MHC class II epitopes [plasma membrane]
        
        Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Sus scrofa)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Sus scrofa)
        
        MHC class II epitopes [plasma membrane]
      - Inactivation of Lck by Csk (Sus scrofa)
        
        Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] (Sus scrofa)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Sus scrofa)
        
        MHC class II epitopes [plasma membrane]
        
        Antigen-bearing MHC Class II : TCR complex:CD4:p-Lck(Y505) [plasma membrane] (Sus scrofa)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Sus scrofa)
        
        MHC class II epitopes [plasma membrane]
      - Phosphorylation of ITAM motifs in CD3 complexes (Sus scrofa)
        
        Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Sus scrofa)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Sus scrofa)
        
        MHC class II epitopes [plasma membrane]
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Sus scrofa)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Sus scrofa)
        
        MHC class II epitopes [plasma membrane]
    - Translocation of ZAP-70 to Immunological synapse (Sus scrofa)
      - Activation of ZAP-70 (Sus scrofa)
        
        Activated ZAP-70 [plasma membrane] (Sus scrofa)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Sus scrofa)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Sus scrofa)
        
        MHC class II epitopes [plasma membrane]
        
        phospho tyrosine ZAP-70 [plasma membrane] (Sus scrofa)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Sus scrofa)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Sus scrofa)
        
        MHC class II epitopes [plasma membrane]
      - PTPN22 dephosphorylates ZAP70 (Sus scrofa)
        
        ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] (Sus scrofa)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Sus scrofa)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Sus scrofa)
        
        MHC class II epitopes [plasma membrane]
        
        phospho tyrosine ZAP-70 [plasma membrane] (Sus scrofa)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Sus scrofa)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Sus scrofa)
        
        MHC class II epitopes [plasma membrane]
      - Phosphorylation of ZAP-70 by Lck (Sus scrofa)
        
        Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Sus scrofa)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Sus scrofa)
        
        MHC class II epitopes [plasma membrane]
        
        ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] (Sus scrofa)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Sus scrofa)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Sus scrofa)
        
        MHC class II epitopes [plasma membrane]
        
        phospho tyrosine ZAP-70 [plasma membrane] (Sus scrofa)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Sus scrofa)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Sus scrofa)
        
        MHC class II epitopes [plasma membrane]

Immune System (Xenopus tropicalis)

- Adaptive Immune System (Xenopus tropicalis)
  - Regulation of T cell activation by CD28 family (Xenopus tropicalis)
    - Co-inhibition by PD-1 (Xenopus tropicalis)
      - Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Xenopus tropicalis)
        
        Antigen-bearing MHC Class II: TCR with dephosphorylated CD3 zeta chain:CD4 [plasma membrane] (Xenopus tropicalis)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Xenopus tropicalis)
        
        MHC class II epitopes [plasma membrane]
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Xenopus tropicalis)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Xenopus tropicalis)
        
        MHC class II epitopes [plasma membrane]
  - TCR signaling (Xenopus tropicalis)
    - Generation of second messenger molecules (Xenopus tropicalis)
      - Phosphorylation of PLC-gamma1 (Xenopus tropicalis)
        
        ZAP-70 and ITK tyrosine kinases [plasma membrane] (Xenopus tropicalis)
        
        Activated ZAP-70 [plasma membrane] (Xenopus tropicalis)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Xenopus tropicalis)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Xenopus tropicalis)
        
        MHC class II epitopes [plasma membrane]
    - Phosphorylation of CD3 and TCR zeta chains (Xenopus tropicalis)
      - Activation of Lck (Xenopus tropicalis)
        
        Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] (Xenopus tropicalis)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Xenopus tropicalis)
        
        MHC class II epitopes [plasma membrane]
        
        Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Xenopus tropicalis)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Xenopus tropicalis)
        
        MHC class II epitopes [plasma membrane]
      - Inactivation of Lck by Csk (Xenopus tropicalis)
        
        Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] (Xenopus tropicalis)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Xenopus tropicalis)
        
        MHC class II epitopes [plasma membrane]
        
        Antigen-bearing MHC Class II : TCR complex:CD4:p-Lck(Y505) [plasma membrane] (Xenopus tropicalis)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Xenopus tropicalis)
        
        MHC class II epitopes [plasma membrane]
      - Phosphorylation of ITAM motifs in CD3 complexes (Xenopus tropicalis)
        
        Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Xenopus tropicalis)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Xenopus tropicalis)
        
        MHC class II epitopes [plasma membrane]
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Xenopus tropicalis)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Xenopus tropicalis)
        
        MHC class II epitopes [plasma membrane]
    - Translocation of ZAP-70 to Immunological synapse (Xenopus tropicalis)
      - Activation of ZAP-70 (Xenopus tropicalis)
        
        Activated ZAP-70 [plasma membrane] (Xenopus tropicalis)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Xenopus tropicalis)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Xenopus tropicalis)
        
        MHC class II epitopes [plasma membrane]
        
        phospho tyrosine ZAP-70 [plasma membrane] (Xenopus tropicalis)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Xenopus tropicalis)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Xenopus tropicalis)
        
        MHC class II epitopes [plasma membrane]
      - Phosphorylation of ZAP-70 by Lck (Xenopus tropicalis)
        
        Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Xenopus tropicalis)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Xenopus tropicalis)
        
        MHC class II epitopes [plasma membrane]
        
        ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] (Xenopus tropicalis)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Xenopus tropicalis)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Xenopus tropicalis)
        
        MHC class II epitopes [plasma membrane]
        
        phospho tyrosine ZAP-70 [plasma membrane] (Xenopus tropicalis)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Xenopus tropicalis)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Xenopus tropicalis)
        
        MHC class II epitopes [plasma membrane]
      - Recruitment of ZAP-70 to phosphorylated ITAMs (Xenopus tropicalis)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Xenopus tropicalis)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Xenopus tropicalis)
        
        MHC class II epitopes [plasma membrane]
        
        ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] (Xenopus tropicalis)
        
        Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Xenopus tropicalis)
        
        MHC Class II bearing antigen peptide [plasma membrane] (Xenopus tropicalis)
        
        MHC class II epitopes [plasma membrane]

Participates

as a component of

Cross References

ChEBI

166824, 15841

Cite Us!