New and Updated Pathways. In version V63, topics with new or revised pathways include Immune System (Interleukin-20  family signaling, Interleukin-21 signaling, Interleukin-37 signaling, and other Interleukin signaling), Metabolism (Vitamin D (calciferol) metabolism), and Signal Transduction (Signaling by NOTCH3). Illustrations are now available for DNA Repair, Base Excision Repair, Signaling by GPCR,  GPCR ligand binding,  GPCR downstream signaling, and Translation.

Thanks to our Contributors. Laurence Bindoff, Roberta Carriero, Sandip Datta, Cecilia Garlanda, Elzbieta Glaser, Michael Holick, Tony Kouzarides , Alberto Mantovani, and Birgit Meldal are our external reviewers.

Annotation Statistics. Reactome comprises 11,426 human reactions organized into 2,179 pathways involving 10,996 proteins encoded by 10,739 different human genes, 1,764 small molecules, and 11,366 complexes. These annotations are supported by 27,694 literature references. We have projected these reactions onto 138,985 orthologous proteins, creating 20,932 orthologous pathways in 18 non-human species. Version 63 has annotations for 1,334 protein variants (mutated proteins) and their post-translationally modified forms, derived from 287 proteins. These have been used to annotate 506 disease-specific complexes and 906 disease-specific reactions organized into 453 pathways and subpathways, and tagged with 294 Disease Ontology terms.

About the Reactome Project. Reactome is a collaboration between groups at the Ontario Institute for Cancer Research, Oregon Health and Science University, New York University Langone Medical Center, and The European Bioinformatics Institute. Reactome annotation files and interaction data derived from Reactome are distributed under a Creative Commons Public Domain (CC0 1.0 Universal) Licence,. A Creative Commons Attribution 4.0 International (CC BY 4.0) Licence will apply to all software and code, database data dumps, and Pathway Illustrations (Enhanced High-Level Diagrams), Icon Library, Art and Branding Materials. A full description of the new and updated content is available on the ,..

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