New and Updated Pathways. In version V62, topics with new or revised pathways include Developmental biology (Signaling by Robo receptor), Gene expression  (Transcriptional regulation by E2F6  and Transcriptional regulation by RUNX2), and Immune System (Interleukin-7 family signaling, Interleukin-15  family signalingInterleukin-35  family signaling, and Interleukin-38  family signaling). Illustrations are now available for Aquaporin-mediated transportCellular senescenceEpigenetic regulation of gene expressionGene ExpressionNegative epigenetic regulation of rRNA expressionO2/CO2 exchange in erythrocytesPeptide hormone metabolism, Positive epigenetic regulation of rRNA expressionPost-translational protein modificationResponse to metal ionsSignal Transduction, and SLC-mediated transmembrane transport.

Thanks to our Contributors. Patricia Ducy is our external author. Patricia DucyJorg GoronzyAnna HerlihyAlexander  JaworskiUmesh  KumarJavier Francisco MoraManoj PatidarYuliya  Pylayeva-GuptaKailash Singh, and Ren Sun are our external reviewers.

Annotation Statistics. Reactome comprises 11,302 human reactions organized into 2,176 pathways involving 10,878 proteins encoded by 10,712 different human genes, 1,768 small molecules, and 11,284 complexes. These annotations are supported by 27,526 literature references. We have projected these reactions onto 121,709 orthologous proteins, creating 20,854 orthologous pathways in 18 non-human species. Version 62 has annotations for 1,334 protein variants (mutated proteins) and their post-translationally modified forms, derived from 285 proteins. These have been used to annotate 506 disease-specific complexes and 906 disease-specific reactions organized into 453 pathways and subpathways, and tagged with 294 Disease Ontology terms.

About the Reactome Project. Reactome is a collaboration between groups at the Ontario Institute for Cancer Research, Oregon Health and Science University, New York University Langone Medical Center, and The European Bioinformatics Institute. Reactome data and software are distributed under the terms of the Creative Commons Attribution 4.0 License. A full description of the new and updated content is available on the Reactome website.

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