New and Updated Pathways. In version V60, topics with new or revised pathways include: Cell cycle (Cyclin D associated events in G1), Cell-cell communication (SDK interactions), Cellular response to external stimuli (HSP90 chaperone cycle for steroid hormone receptors (SHR)), Disease (Diseases of Mismatch Repair), Gene Expression (TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest and Transcriptional Regulation by the CBFB:RUNX3 complex), Immune System (Butyrophilins and Regulation of complement cascade), Metabolism (Synthesis of IP2, IP, and Ins in the cytosol, Synthesis of PIPs at the early endosome membrane, Synthesis of PIPs at the ER membrane, Synthesis of PIPs at the late endosome membrane, and Synthesis of PIPs at the plasma membrane), Metabolism of proteins (CREB3 factors activate genes, Neddylation, Protein ubiquitination, and SUMOylation of chromatin organizing proteins), Mitophagy (Receptor Mediated Mitophagy), Neuronal System (Receptor protein tyrosine phosphatases interactions), Organelle biogenesis and maintenance (Cristae formation), and Transport of small molecules (Mitochondrial calcium ion transport).

Thanks to our Contributors.  Wei-Chih Yang and Jian Lu are our external  authors. Joseph Ainscough, Sanjeevani  Arora, Jorge E Azevedo,  Jeehyeon Bae, Lucia Banci, Gautam Bhave, David R Brown, Roberta Bulla, Alexandre M Carmo, Linda Shyue Huey Chuang, Karlene A Cimprich, Laura Crisponi, Alain de Bruin, Luisa Di Stefano , Ilaria Drago, Pablo C Echeverria, Du Feng, Emer S Ferro, Dianne Ford, Frances V Fuller-Pace, Cem Gabay, Dominique Gagliardi, Marcia  Haigis, J Wade Harper, Barry Honig, Yoshiaki Ito, Veerle Janssens, Nathalie Josso, Jaewon  Ko , Vera Kozjak-Pavlovic, Anastasia Kralli, Paul J Lehner, Dominique  Leprince, Bruce D Levy, Wei Li, Francisco Lozano, Jian Lu, Michael J Matunis, Birgit Meldal, Violaine Moreau, Kyungjae Myung, Joseph H Neale, Christian Obinger,  R Jeroen Pasterkamp, Richard Phipps, Didier Picard, Elah Pick, David A Rhodes, Pier e P Roger, Mark G Rush, Joshua R Sanes, Martin Schröder, Pierre Thibault, Dick J H van den Boomen , Thomas E Van Dyke, Roberto M Vanacore, Nobutaka Wakamiya, Qinglu Wang, Bart Westendorp, Sandra E Wiley, Miriam Wittmann, Guilherme Xavier, Wei-Chih Yang, Ali A Zarrin, and Bing Zhu are our external reviewers.

Annotation Statistics. Reactome comprises 10,754 human reactions organized into 2,132 pathways involving 10,907 proteins encoded by 10,658 different human genes, 1,763 small molecules, and 10,748 complexes. These annotations are supported by 26,384 literature references. We have projected these reactions onto 115,881 orthologous proteins, creating 20,701 orthologous pathways in 18 non-human species. Version 60 has annotations for 1,503 protein variants (mutated proteins) and their post-translationally modified forms, derived from 285 proteins. These have been used to annotate 506 disease-specific complexes and 906 disease-specific reactions organized into 453 pathways and subpathways, and tagged with 294 Disease Ontology terms.

About the Reactome Project. Reactome is a collaboration between groups at the Ontario Institute for Cancer Research, Oregon Health and Science University, New York University Langone Medical Center, and The European Bioinformatics Institute. Reactome data and software are distributed under the terms of the Creative Commons Attribution 4.0 License. A full description of the new and updated content is available on the Reactome website.

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