Maternal to zygotic transition
New and Updated Topics and Pathways. In V86, Topics with new or revised pathways include Cellular responses to stimuli (KEAP1-NFE2L2 pathway), Developmental biology (Formation of anterior neural plate, Formation of posterior neural plate, and Maternal to zygotic transition (MZT)), Immune system (PKR-mediated signaling), Metabolism (Vitamin B5 (pantothenate) metabolism), Metabolism of RNA (Mitochondrial RNA degradation), and Metabolism of proteins (Protein hydroxylation).
New and Updated Illustrations. New or revised Illustrations with embedded navigation features have been created for Antiviral mechanism by IFN-stimulated genes, Developmental Biology, Gastrulation, Maternal to zygotic transition, and Metabolism of RNA.
Thanks to our Contributors. David Hill, Hisato Kondoh, Rekha Patel, and Wei Xie are our external reviewers.
Annotation Statistics. Reactome comprises 14,803 human reactions organized into 2,647 pathways involving 30,338 proteins and modified forms of proteins encoded by 11,154 different human genes, 14,441 complexes, 2,025 small molecules, and 1,119 drugs. These annotations are supported by 37,156 literature references. We have projected these reactions onto 84,414 orthologous proteins, creating 19,561 orthologous pathways in 14 non-human species. Version 86 has annotations for 4,919 protein variants (mutated proteins) and their post-translationally modified forms, derived from 354 proteins, which have contributed to the annotation of 1,667 disease-specific reactions and 707 pathways.
Tools and Data. Our services and software tools are designed for biologists, bioinformaticians, and software developers. Pathway data is available to view in our Pathway Browser, to analyze your own dataset, to download, and access programmatically through our Content and Analysis Services. The ReactomeFIViz app and ReactomeGSA package provide tools for multi-omics data analysis. The idg.reactome.org Web Portal provides a collection of web-based tools to help researchers place understudied proteins in a pathway context.
Documentation and Training. Visit our online User Guide to access documentation supporting pathway analysis of experimental data. The Developer's Zone provides detailed documentation regarding our software, tools, and web services. Training and learning materials can be found here.
About the Reactome Project. Reactome is a collaboration between groups at the Ontario Institute for Cancer Research, Oregon Health and Science University, New York University Langone Medical Center, and The EMBL - European Bioinformatics Institute. Reactome is an ELIXIR Core Data Resource as well as a Global Core Biodata Resource. Reactome annotation files and interaction data derived from Reactome are distributed under a Creative Commons Public Domain (CC0 1.0 Universal) Licence. A Creative Commons Attribution 4.0 International (CC BY 4.0) Licence applies to all software and code, database data dumps, and Pathway Illustrations (Enhanced High-Level Diagrams), Icon Library, Art and Branding Materials. A full description of the new and updated content is available on the Reactome website.
For more information: If you have a question, want to provide feedback, or are interested in collaborating with us to annotate a topic, please contact us at This email address is being protected from spambots. You need JavaScript enabled to view it..
