R HSA 3229121

New and Updated Topics and Pathways. In V80, Topics with new or revised pathways include Cellular responses to stimuli (Cellular response to chemical stress, Cytoprotection by HMOX1, KEAP1-NFE2L2 pathway), Disease (Defective HDR through Homologous Recombination (HRR) Due to BRCA2 Loss of Function, Diseases of nucleotide metabolism, and SARS-CoV-2-host interactions), DNA repair (Presynaptic phase of homologous DNA pairing and strand exchange), Drug ADME (Atorvastatin ADME), Metabolism (Cobalamin (Cbl, vitamin B12) transport and metabolism), and Metabolism of Proteins (Neddylation).

New and Updated Illustrations. Cellular response to chemical stress, Defects in cobalamin (B12) metabolism, Diseases of Metabolism, Diseases of Mismatch Repair (MMR), Diseases of nucleotide metabolism, Drug Absorption, Distribution, Metabolism and Excretion (ADME), Glycogen storage diseases, RAS GTPase cycle mutants, and Signaling by MRAS-complex mutants have a new or revised Illustration with embedded navigation features.

Thanks to our Contributors. Antonio Cuadrado, Wolf-Dietrich Heyer, David P Hill, Rachel HuddartHang Phuong Le, Jie Liu, Francesco Messina, and Julia Somers are our external reviewers.

Annotation Statistics. Reactome comprises 14,108 human reactions organized into 2,580 pathways involving 11,285 proteins and modified forms of proteins encoded by 11,084 different human genes, 13,869 complexes, 1,987 small molecules, and 532 drugs. These annotations are supported by 34,703 literature references. We have projected these reactions onto 77,392 orthologous proteins, creating 18,830 orthologous pathways in 15 non-human species. Version 80 has annotations for 5,422 protein variants (mutated proteins) and their post-translationally modified forms, derived from 352 proteins, which have been used to annotate disease-specific 1,601 reactions and 695 pathways.

Tools and Data. Our services and software tools are designed for biologists, bioinformaticians, and software developers. Pathway data is available to view in our Pathway Browser, to analyze your own dataset, to download, and access programmatically through our Content and Analysis Services. The ReactomeGSA package provides tools for multi-omics data analysis. The idg.reactome.org Web Portal provides a collection of web-based tools to help researchers place understudied proteins in a pathway context. 

Documentation and Training. Visit our online User Guide to access documentation supporting pathway analysis of experimental data. The Developer's Zone provides detailed documentation regarding our software, tools, and web services. Training and learning materials can be found here.

About the Reactome Project. Reactome is a collaboration between groups at the Ontario Institute for Cancer Research, Oregon Health and Science University, New York University Langone Medical Center, and The European Bioinformatics Institute. Reactome annotation files and interaction data derived from Reactome are distributed under a Creative Commons Public Domain (CC0 1.0 Universal) Licence. A Creative Commons Attribution 4.0 International (CC BY 4.0) Licence will apply to all software and code, database data dumps, and Pathway Illustrations (Enhanced High-Level Diagrams), Icon Library, Art and Branding Materials. A full description of the new and updated content is available on the Reactome website.

Follow us on Twitter: @reactome to get frequent updates about new and updated pathways, feature updates, and more!

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