New and Updated Topics and Pathways. In V79 we have introduced the new topic Drug Absorption, Distribution, Metabolism and Excretion in which we cover both pharmacokinetics and pharmacodynamics of Aspirin, Azathioprine, and Paracetamol. Topics with new or revised pathways in this release include Cell Cycle (Cyclin D associated events in G1 and Drug-mediated inhibition of CDK4/CDK6 activity), DNA Replication (Assembly of the pre-replicative complex), Immune System (Interferon alpha/beta signaling), Metabolism (Cholesterol biosynthesis and Choline catabolism), and Sensory Perception (Expression and translocation of Olfactory Receptors).

New and Updated Illustrations. Illustrations with embedded navigation features have been added or revised for Diseases associated with glycosaminoglycan metabolism, Diseases associated with glycosylation precursor biosynthesis,Diseases associated with N-glycosylation of proteins, Diseases of Telomere Maintenance, DNA Replication, Drug Absorption, Distribution, Metabolism, and Excretion (ADME), Drug resistance of ALK mutants, Drug resistance of FLT3 mutants, Drug resistance of KIT mutants, Drug resistance of PDGFR mutants, Metabolism, Signaling by AMER1 mutants, Signaling by APC mutants, Signaling by AXIN mutants, Signaling by CTNNB1 phospho-site mutants.

Thanks to our Contributors. Our external authors are Jelena Kusic-Tisma and Damjana Rozman. Our external reviewers are Andrew J Brown, Rachel Huddart, Anne Morgat, Sisira Kadambat Nair, Alexander F Palazzo, Francesco Raimondi, Qingtang Shen.

Annotation Statistics. Reactome comprises 13,960 human reactions organized into 2,553 pathways involving 11,270 proteins and modified forms of proteins encoded by 11,071 different human genes, 13,853 complexes, 1,987 small molecules, and 527 drugs. These annotations are supported by 34,252 literature references. We have projected these reactions onto 77,418 orthologous proteins, creating 19,597 orthologous pathways in 15 non-human species. Version 79 has annotations for 5,064 protein variants (mutated proteins) and their post-translationally modified forms, derived from 347 proteins, which have been used to annotate disease-specific 1,540 reactions and 674 pathways.

Tools and Data. Our services and software tools are designed for biologists, bioinformaticians, and software developers. Pathway data is available to view in our Pathway Browser, to analyze your own dataset, to download, and access programmatically through our Content and Analysis Services. The ReactomeGSA package provides tools for multi-omics data analysis. The idg.reactome.org Web Portal provides a collection of web-based tools to help researchers place understudied proteins in a pathway context. 

Documentation and Training. Visit our online User Guide to access documentation supporting pathway analysis of experimental data. The Developer's Zone provides detailed documentation regarding our software, tools, and web services. Training and learning materials can be found here.

About the Reactome Project. Reactome is a collaboration between groups at the Ontario Institute for Cancer Research, Oregon Health and Science University, New York University Langone Medical Center, and The European Bioinformatics Institute. Reactome annotation files and interaction data derived from Reactome are distributed under a Creative Commons Public Domain (CC0 1.0 Universal) Licence. A Creative Commons Attribution 4.0 International (CC BY 4.0) Licence will apply to all software and code, database data dumps, and Pathway Illustrations (Enhanced High-Level Diagrams), Icon Library, Art and Branding Materials. A full description of the new and updated content is available on the Reactome website.

Follow us on Twitter: @reactome to get frequent updates about new and updated pathways, feature updates, and more!

For more information: If you have a question to ask or would like to give us your feedback, please contact our helpdesk.

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