New and Updated Topics and Pathways. Topics with new or revised pathways in V76 include Cellular responses to external stimuli (Cytoprotection by HMOX1 and Heme signaling), Disease (Defective pyroptosis), Gene Expression (tRNA-derived small RNA (tsRNA) biogenesis), Immune system (DDX58/IFIH1-mediated induction of interferon-alpha/beta and Signaling by CSF3 (G-CSF)), Programmed cell death (Pyroptosis), Sensory Perception (Sensory processing of sound), and Signal transduction (Miro GTPase Cycle, RHO GTPase Cycle, and RHOH GTPase Cycle).
New and Updated Illustrations. Illustrations with embedded navigation features have been added or revised for Cellular responses to stress, Cytokine Signaling in Immune system, Diseases of Metabolism, Metabolic disorders of biological oxidations enzymes, Sensory Perception, and Sensory processing of sound.
Thanks to our Contributors. Our external reviewers are Katia Basso, Ines Castro, Peter Dallos, Anindya Dutta, Philippe Fort, David N. Furness, Thirumala-Devi Kanneganti, Carlos Henrique Inacio Ramos, Michael Schrader, Hans-Uwe Simon, Julia Somers, Zhangli Su, Ivo P. Touw, Briana Wilson, and Zhibin Zhang.
Annotation Statistics. Reactome comprises 13,732 human reactions organized into 2,516 pathways involving 11,362 proteins and modified forms of proteins encoded by 11,073 different human genes, 13,409 complexes, 1,856 small molecules, and 415 drugs. These annotations are supported by 33,453 literature references. We have projected these reactions onto 74,384 orthologous proteins, creating 18,051 orthologous pathways in 15 non-human species. Version 76 has annotations for 2,949 protein variants (mutated proteins) and their post-translationally modified forms, derived from 337 proteins, which have been used to annotate disease-specific 1,550 reactions and 653 pathways.
Tools and Data. Our services and software tools are designed for biologists, bioinformaticians, and software developers. Pathway data is available to view in our Pathway Browser, to analyze your own dataset, to download, and to access programmatically through our Content and Analysis Services. The ReactomeFIViz app for Cytoscape and the ReactomeGSA package provides tools for multi-omics data analysis.
Documentation and Training. Visit our online User Guide to access documentation supporting pathway analysis of experimental data. The Developer's Zone provides detailed documentation regarding our software, tools, and web services. Training and learning materials can be found here.
About the Reactome Project. Reactome is a collaboration between groups at the Ontario Institute for Cancer Research, Oregon Health and Science University, New York University Langone Medical Center, and The European Bioinformatics Institute. Reactome annotation files and interaction data derived from Reactome are distributed under a Creative Commons Public Domain (CC0 1.0 Universal) Licence. A Creative Commons Attribution 4.0 International (CC BY 4.0) Licence will apply to all software and code, database data dumps, and Pathway Illustrations (Enhanced High-Level Diagrams), Icon Library, Art and Branding Materials. A full description of the new and updated content is available on the Reactome website.
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