New and Updated Pathways. Topics with new or revised pathways in release 75 include Developmental biology (Transcriptional regulation of testis differentiation), Disease (Alternative lengthening of telomeres, Defective DNA double strand break response due to BARD1 loss of function, Defective DNA double strand break response due to BRCA1 loss of function, Signaling by FLT3 in disease), DNA Repair (Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks), Immune system (FLT3 signaling), and Signal transduction (RHOBTB GTPase cycle).
New and Updated Illustrations. Illustrations with embedded navigation features have been added or revised for Developmental biology, Diseases associated with visual transduction, Diseases of DNA repair, Diseases of hemostasis, Diseases of the immune system, Diseases of mitotic cell cycle, Diseases of signal transduction by growth factor receptors and second messengers, FLT3 signaling in disease, Hh mutants abrogate ligand secretion, PI3PK/AKT signaling in cancer, Selective autophagy, Signaling by ERBB2 in cancer, Signaling by PDGFR in disease, Signaling by WNT in cancer, and Uptake and actions of bacterial toxins.
Thanks to our Contributors. Our external authors are Richard J Baer and Francisco Rivero Crespo. Our external reviewers are Richard J Baer, Kenya Imaimatsu, Yoshiakira Kanai, Julhash Kazi, Alan Meeker, Roger Reddel, and Francisco Rivero Crespo.
Annotation Statistics. Reactome comprises 13,534 human reactions organized into 2,477 pathways involving 11,118 proteins and modified forms of proteins encoded by 10,929 different human genes, 13,210 complexes, 1,854 small molecules, and 414 drugs. These annotations are supported by 32,493 literature references. We have projected these reactions onto 79,333 orthologous proteins, creating 18,510 orthologous pathways in 15 non-human species. Version 75 has annotations for 2,620 protein variants (mutated proteins) and their post-translationally modified forms, derived from 327 proteins, which have been used to annotate disease-specific 1,297 reactions and 605 pathways.
Tools and Data. Our services and software tools are designed for biologists, bioinformaticians, and software developers. Pathway data is available to view in our Pathway Browser, to analyze your own dataset, to download, and to access programmatically through our Content and Analysis Services. The ReactomeFIViz app for Cytoscape provides tools to find pathways and network patterns related to cancer and other types of diseases.
Documentation and Training. Visit our online User Guide to access documentation supporting pathway analysis of experimental data. The Developer's Zone provides detailed documentation regarding our software, tools, and web services. Training and learning materials can be found here.
About the Reactome Project. Reactome is a collaboration between groups at the Ontario Institute for Cancer Research, Oregon Health and Science University, New York University Langone Medical Center, and The European Bioinformatics Institute. Reactome annotation files and interaction data derived from Reactome are distributed under a Creative Commons Public Domain (CC0 1.0 Universal) Licence. A Creative Commons Attribution 4.0 International (CC BY 4.0) Licence will apply to all software and code, database data dumps, and Pathway Illustrations (Enhanced High-Level Diagrams), Icon Library, Art and Branding Materials. A full description of the new and updated content is available on the Reactome website.
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