New and Updated Pathways. In version V69, Autophagy, including Chaperone Mediated Autophagy and Microautophagy is new.  Topics with new or revised pathways include Development (Transcriptional Regulation of Granulopoiesis), Disease (Evasion of Oncogene Induced Senescence Due to p16-INK4A Defects and Evasion of Oxidative Stress Induced Senescence Due to p16-INK4A Defects), Immune system (FLT3 Signaling), and Signal Transduction (Extra-Nuclear Estrogen Signaling and Signaling by ERBB4). 

New Illustrations. Illustration with embedded navigation features is now available for Autophagy.

Thanks to our Contributors. David Stern is our external author. Filippo AcconciaDorothy BennettMaria MarinoEmmanouil MetzakopianJulia Skokowa, and Elie Traer are our external reviewers. 

Annotation Statistics. Reactome comprises 12,505 human reactions organized into 2,272 pathways involving 11,009 proteins and modified forms of proteins encoded by 10,833 different human genes, 1,857 small molecules, and 196 drugs. These annotations are supported by 30.027 literature references. We have projected these reactions onto 81,631 orthologous proteins, creating 18,610 orthologous pathways in 15 non-human species. Version 69 has annotations for 1,612 protein variants (mutated proteins) and their post-translationally modified forms, derived from 305 proteins. These have been used to annotate 532 complexes and 968 disease-specific reactions organized into 478 pathways and subpathways, and tagged with 374 Disease Ontology terms.

Tools and Data. Our services and software tools are designed for biologists, bioinformaticians, and software developers. Pathway data is available to view in our Pathway Browser, to analyze your own dataset, to download, and to access programmatically through our Content and Analysis Services. The ReactomeFIViz app for Cytoscape provides tools to find pathways and network patterns related to cancer and other types of diseases.

Documentation and Training. Visit our online User Guide to access documentation supporting pathway analysis of experimental data. The Developer's Zone provides detailed documentation regarding our software, tools, and web services. Training and learning materials can be found here.

About the Reactome Project. Reactome is a collaboration between groups at the Ontario Institute for Cancer Research, Oregon Health and Science University, New York University Langone Medical Center, and The European Bioinformatics Institute. Reactome annotation files and interaction data derived from Reactome are distributed under a Creative Commons Public Domain (CC0 1.0 Universal) Licence. A Creative Commons Attribution 4.0 International (CC BY 4.0) Licence will apply to all software and code, database data dumps, and Pathway Illustrations (Enhanced High-Level Diagrams), Icon Library, Art and Branding Materials. A full description of the new and updated content is available on the Reactome website.

Follow us on Twitter: @reactome to get frequent updates about new and updated pathways, feature updates, and more!

For more information: If you have a question to ask or would like to give us your feedback, please contact our This email address is being protected from spambots. You need JavaScript enabled to view it..

Cite Us!