New and Updated Pathways. In version V65, topics with new or revised pathways include Immune System (Interleukin-9 signalingand Signal Transduction (Signaling by NOTCH4 and Signaling by NTRK3 (TRKC)). Illustrations with embedded navigation features are now available for Carbohydrate Metabolism and Homology Directed Repair.

Thanks to our Contributors. Jorge Azevedo, Antonio G√≥mez-Outes, Jan HaavikEun-Kyeong Jo, Paula Licona-Limon, Jared Rutter, and Pantelis Tsoulfas, are our external reviewers.

Annotation Statistics. Reactome comprises 11,896 human reactions organized into 2,222 pathways involving 10,935 proteins encoded by 10,763 different human genes, 1,880 small molecules, and 11,674 complexes. These annotations are supported by 28,436 literature references. We have projected these reactions onto 159,163 orthologous proteins, creating 23,450 orthologous pathways in 18 non-human species. Version 65 has annotations for 1,339 protein variants (mutated proteins) and their post-translationally modified forms, derived from 289 proteins, which have been used to annotate disease-specific complexes, reactions and pathways.

About the Reactome Project. Reactome is a collaboration between groups at the Ontario Institute for Cancer Research, Oregon Health and Science University, New York University Langone Medical Center, and The European Bioinformatics Institute. Reactome annotation files and interaction data derived from Reactome are distributed under a Creative Commons Public Domain (CC0 1.0 Universal) Licence, A Creative Commons Attribution 4.0 International (CC BY 4.0) Licence will apply to all software and code, database data dumps, and Pathway Illustrations (Enhanced High-Level Diagrams), Icon Library, Art and Branding Materials. A full description of the new and updated content is available on the Reactome website.

Follow us on Twitter: @reactome to get frequent updates about new and updated pathways, feature updates, and more!

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