New and Updated Pathways. In version V64, topics with new or revised pathways include Signal Transduction (ESR-mediated signaling and Signaling by NTRK2), Metabolism (Biosynthesis of specialized proresolving mediators (SPMs)), and Metabolism of proteins (Peroxisomal protein import).
Thanks to our Contributors. Hanna Antila, Jorge Azevedo, Kumar Belani, Gerry Boss, Matthew Brenner, Eero Castrén, Arthur Cooper, Diana Downs, Marc Fransen, Trond Hansen, Hui-Chih Hung, Margaret James, Pidder Jansen-Duerr, Hideo Kimura, Luca Magnani, Steven Patterson, Paul Van Veldhoven, Alexander Weiss, and Herman Wolosker are our external reviewers.
Illustrations with embedded navigation features are now available for Digestion and absorption, DNA Double-Strand Break Repair, Signaling by receptor tyrosine kinases, Signaling by FGFR, MAPK family signaling cascades, MAPK1/MAPK3 signaling, Signaling by TGF-beta family, RHO GTPase Effectors, Signaling by Wnt, Signaling by Hedgehog, Death Receptor Signaling, and Intracellular signaling by second messengers.
Annotation Statistics. Reactome comprises 11,754 human reactions organized into 2,216 pathways involving 11,030 proteins encoded by 10,762 different human genes, 1,867 small molecules, and 11,561 complexes. These annotations are supported by 28,254 literature references. We have projected these reactions onto 140,720 orthologous proteins, creating 21,223 orthologous pathways in 18 non-human species. Version 64 has annotations for 1,339 protein variants (mutated proteins) and their post-translationally modified forms, derived from 289 proteins, which have been used to annotate disease-specific complexes, reactions and pathways.
About the Reactome Project. Reactome is a collaboration between groups at the Ontario Institute for Cancer Research, Oregon Health and Science University, New York University Langone Medical Center, and The European Bioinformatics Institute. Reactome annotation files and interaction data derived from Reactome are distributed under a Creative Commons Public Domain (CC0 1.0 Universal) Licence, A Creative Commons Attribution 4.0 International (CC BY 4.0) Licence will apply to all software and code, database data dumps, and Pathway Illustrations (Enhanced High-Level Diagrams), Icon Library, Art and Branding Materials. A full description of the new and updated content is available on the Reactome website.
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