R-HSA-5602358_v88CHUKIKBKGIKBKBCHUKENDOPLASMIC RETICULUMENDOSOMEviral dsRNATLR3TLR3TLR7TLR4TLR5BACTERIAL FLAGELLINIKBKBIKBKB DEFICIENCY CAUSES SCIDXXX/YYYIKBKGIKBKG DEFICIENCY CAUSESANHIDROTIC ECTODERMAL DYSPLASIAWITH IMMUNODEFICIENCY (EDA-ID) (VIA TLR)XXX/YYYIRAK4IRAK4IRAK4 DEFICIENCY (TLR2/4)XXX/YYYIRAK4IRAK4IRAK4 DEFICIENCY (TLR5)XXX/YYYMYD88MYD88MYD88 DEFICIENCY (TLR2/4)XXX/YYYMYD88MYD88MYD88 DEFICIENCY (TLR5)XXX/YYYTLR3 DEFICIENCY - HSEXXX/YYYTICAM1TICAM1TICAM1 DEFICIENCY - HSEXXX/YYYTRAF3TRAF3TRAF3 DEFICIENCY - HSEXXX/YYYUNC93B1UNC93B1UNC93B1 DEFICIENCY - HSEXXX/YYYRELARELANFKB1NFKB1NFKBIANFKBIAIKBA VARIANT LEADS TO EDA-IDXXX/YYYDEFECTIVE REGULATION OF TLR BY ENDOGENOUS LIGANDXXX/YYY