R-HSA-2644603ONCOGENIC OVEREXPRESSIONOF NOTCH1 TARGET GENESUbRBX1SKP1FBXW7CUL1CYTOSOLNUCLEUSNOTCH1-ICDNOTCH1-ICDwith mutantPEST domainNEIGHBORING CELL CYTOSOLDLL/JAG ligandligand-dependentcleavageligand-independentcleavageligand-independentcleavageNOTCH1 PESTdomain mutantNOTCH1 HD + PESTdomain mutantNOTCH1HD mutantNOTCH1 t(7;9)(q34;q34.3)translocation mutantNOTCH1target genesDefectiveubiquin-dependentdegradationSCF E3complexSIGNALING BY NOTCH1 t(7;9)(NOTCH1:M1580_K2555)TRANSLOCATION MUTANTXXX/YYYSIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCERXXX/YYYSIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCERXXX/YYYSIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCERXXX/YYYUbRBX1SKP1FBXW7CUL1FBXW7 MUTANTS AND NOTCH1 IN CANCERXXX/YYY