{ "dbId" : 10731572, "stableId" : "R-XTR-9953170", "displayName" : "GBP-mediated host defense", "nodes" : [ { "id" : 108289, "reactomeId" : 29438, "displayName" : "GTP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 553, "y" : 37 }, "minX" : 533, "maxX" : 584, "minY" : 21, "maxY" : 76, "prop" : { "x" : 533, "y" : 22, "width" : 41, "height" : 31 }, "textPosition" : { "x" : 537, "y" : 27 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 569, "y" : 27 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 569, "y" : 27 } } }, "connectors" : [ { "edgeId" : 108286, "type" : "INPUT", "segments" : [ { "from" : { "x" : 565, "y" : 56 }, "to" : { "x" : 584, "y" : 76 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 568, "y" : 60 }, "b" : { "x" : 580, "y" : 72 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 574, "y" : 66 } } } } ] }, { "id" : 108288, "reactomeId" : 10659883, "displayName" : "furin", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 502, "y" : 76 }, "minX" : 481, "maxX" : 584, "minY" : 59, "maxY" : 88, "prop" : { "x" : 481, "y" : 65, "width" : 43, "height" : 23 }, "textPosition" : { "x" : 484, "y" : 66 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 524, "y" : 65 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 524, "y" : 65 } } }, "connectors" : [ { "edgeId" : 108286, "type" : "INPUT", "segments" : [ { "from" : { "x" : 527, "y" : 76 }, "to" : { "x" : 584, "y" : 76 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 549, "y" : 70 }, "b" : { "x" : 561, "y" : 82 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 555, "y" : 76 } } } } ] }, { "id" : 108290, "reactomeId" : 10728069, "displayName" : "FURIN:GGC-GBP5:GTP, FURIN:GGC-GBP2:GTP", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 706, "y" : 76 }, "minX" : 649, "maxX" : 764, "minY" : 51, "maxY" : 102, "prop" : { "x" : 649, "y" : 51, "width" : 115, "height" : 51 }, "textPosition" : { "x" : 649, "y" : 52 }, "connectors" : [ { "edgeId" : 108286, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 108293, "reactomeId" : 10728146, "displayName" : "GBP1:G-actin", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 420, "y" : 148 }, "minX" : 377, "maxX" : 470, "minY" : 131, "maxY" : 160, "prop" : { "x" : 377, "y" : 137, "width" : 87, "height" : 23 }, "textPosition" : { "x" : 391, "y" : 125 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 464, "y" : 137 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 464, "y" : 137 } } }, "connectors" : [ { "edgeId" : 108291, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 108292, "reactomeId" : 10666259, "displayName" : "G-actin", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 292, "y" : 117 }, "minX" : 266, "maxX" : 324, "minY" : 100, "maxY" : 150, "prop" : { "x" : 266, "y" : 106, "width" : 52, "height" : 23 }, "textPosition" : { "x" : 266, "y" : 108 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 318, "y" : 106 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 318, "y" : 106 } } }, "connectors" : [ { "edgeId" : 108291, "type" : "INPUT", "segments" : [ { "from" : { "x" : 302, "y" : 132 }, "to" : { "x" : 323, "y" : 150 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 108295, "reactomeId" : 10728158, "displayName" : "Homologues of GBP1(1-192)", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 173, "y" : 114 }, "minX" : 96, "maxX" : 217, "minY" : 103, "maxY" : 155, "prop" : { "x" : 130, "y" : 103, "width" : 87, "height" : 23 }, "textPosition" : { "x" : 129, "y" : 90 }, "connectors" : [ { "edgeId" : 108294, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 151, "y" : 129 }, "to" : { "x" : 96, "y" : 155 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 146, "y" : 136 }, "b" : { "x" : 151, "y" : 129 }, "c" : { "x" : 143, "y" : 128 }, "type" : "ARROW", "centre" : { "x" : 143, "y" : 128 } } } ] }, { "id" : 108297, "reactomeId" : 10675872, "displayName" : "Caspase-1 tetramer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 110, "y" : 66 }, "minX" : 47, "maxX" : 180, "minY" : 49, "maxY" : 147, "prop" : { "x" : 47, "y" : 55, "width" : 127, "height" : 23 }, "textPosition" : { "x" : 71, "y" : 43 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 174, "y" : 55 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 174, "y" : 55 } } }, "connectors" : [ { "edgeId" : 108294, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 85, "y" : 81 }, "to" : { "x" : 65, "y" : 87 } }, { "from" : { "x" : 65, "y" : 87 }, "to" : { "x" : 65, "y" : 139 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 65, "y" : 143 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 65, "y" : 143 } } } ] }, { "id" : 108296, "reactomeId" : 10728168, "displayName" : "Homologues of GBP1(193-592)", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 193, "y" : 154 }, "minX" : 96, "maxX" : 245, "minY" : 143, "maxY" : 166, "prop" : { "x" : 142, "y" : 143, "width" : 103, "height" : 23 }, "textPosition" : { "x" : 141, "y" : 137 }, "connectors" : [ { "edgeId" : 108294, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 139, "y" : 154 }, "to" : { "x" : 96, "y" : 155 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 132, "y" : 158 }, "b" : { "x" : 139, "y" : 154 }, "c" : { "x" : 132, "y" : 150 }, "type" : "ARROW", "centre" : { "x" : 132, "y" : 150 } } } ] }, { "id" : 108299, "reactomeId" : 10728061, "displayName" : "Homologues of S-farn-C589, p-S156, T590-GBP1", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 69, "y" : 393 }, "minX" : 11, "maxX" : 128, "minY" : 375, "maxY" : 467, "prop" : { "x" : 11, "y" : 375, "width" : 117, "height" : 37 }, "textPosition" : { "x" : 11, "y" : 369 }, "connectors" : [ { "edgeId" : 108298, "type" : "INPUT", "segments" : [ { "from" : { "x" : 75, "y" : 415 }, "to" : { "x" : 96, "y" : 467 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 108301, "reactomeId" : 10728073, "displayName" : "S-farn-C,p-S,T-GBP1:SFN dimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 96, "y" : 537 }, "minX" : 44, "maxX" : 154, "minY" : 513, "maxY" : 556, "prop" : { "x" : 44, "y" : 519, "width" : 104, "height" : 37 }, "textPosition" : { "x" : 48, "y" : 507 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 148, "y" : 519 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 148, "y" : 519 } } }, "connectors" : [ { "edgeId" : 108298, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 108300, "reactomeId" : 10658596, "displayName" : "SFN dimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 137, "y" : 438 }, "minX" : 96, "maxX" : 178, "minY" : 421, "maxY" : 467, "prop" : { "x" : 103, "y" : 427, "width" : 69, "height" : 23 }, "textPosition" : { "x" : 116, "y" : 415 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 172, "y" : 427 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 172, "y" : 427 } } }, "connectors" : [ { "edgeId" : 108298, "type" : "INPUT", "segments" : [ { "from" : { "x" : 120, "y" : 453 }, "to" : { "x" : 96, "y" : 467 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 108245, "reactomeId" : 10727916, "displayName" : "Homologues of GBP1", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 68, "y" : 244 }, "minX" : 48, "maxX" : 127, "minY" : 233, "maxY" : 256, "prop" : { "x" : 48, "y" : 233, "width" : 40, "height" : 23 }, "textPosition" : { "x" : 50, "y" : 199 }, "connectors" : [ { "edgeId" : 108294, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 108244, "type" : "INPUT", "segments" : [ { "from" : { "x" : 91, "y" : 243 }, "to" : { "x" : 127, "y" : 243 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 108247, "reactomeId" : 111294, "displayName" : "PPi", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 237, "y" : 211 }, "minX" : 215, "maxX" : 255, "minY" : 195, "maxY" : 243, "prop" : { "x" : 220, "y" : 196, "width" : 34, "height" : 31 }, "textPosition" : { "x" : 223, "y" : 201 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 249, "y" : 201 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 249, "y" : 201 } } }, "connectors" : [ { "edgeId" : 108244, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 226, "y" : 230 }, "to" : { "x" : 215, "y" : 243 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 225, "y" : 238 }, "b" : { "x" : 226, "y" : 230 }, "c" : { "x" : 218, "y" : 233 }, "type" : "ARROW", "centre" : { "x" : 218, "y" : 233 } } } ] }, { "id" : 108246, "reactomeId" : 2530486, "displayName" : "FPP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 105, "y" : 210 }, "minX" : 87, "maxX" : 127, "minY" : 194, "maxY" : 243, "prop" : { "x" : 87, "y" : 195, "width" : 37, "height" : 31 }, "textPosition" : { "x" : 90, "y" : 200 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 119, "y" : 200 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 119, "y" : 200 } } }, "connectors" : [ { "edgeId" : 108244, "type" : "INPUT", "segments" : [ { "from" : { "x" : 115, "y" : 229 }, "to" : { "x" : 127, "y" : 243 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 108249, "reactomeId" : 10691143, "displayName" : "FNTA:FNTB", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 171, "y" : 200 }, "minX" : 134, "maxX" : 214, "minY" : 183, "maxY" : 235, "prop" : { "x" : 134, "y" : 189, "width" : 74, "height" : 23 }, "textPosition" : { "x" : 134, "y" : 191 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 208, "y" : 189 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 208, "y" : 189 } } }, "connectors" : [ { "edgeId" : 108244, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 171, "y" : 215 }, "to" : { "x" : 171, "y" : 227 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 171, "y" : 231 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 171, "y" : 231 } } } ] }, { "id" : 108248, "reactomeId" : 10727874, "displayName" : "Homologues of S-farn-C589-GBP1", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 266, "y" : 278 }, "minX" : 205, "maxX" : 327, "minY" : 150, "maxY" : 312, "prop" : { "x" : 205, "y" : 267, "width" : 122, "height" : 23 }, "textPosition" : { "x" : 207, "y" : 261 }, "connectors" : [ { "edgeId" : 108291, "type" : "INPUT", "segments" : [ { "from" : { "x" : 271, "y" : 264 }, "to" : { "x" : 323, "y" : 150 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 108302, "type" : "INPUT", "segments" : [ { "from" : { "x" : 284, "y" : 293 }, "to" : { "x" : 320, "y" : 312 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 108244, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 249, "y" : 264 }, "to" : { "x" : 215, "y" : 243 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 241, "y" : 264 }, "b" : { "x" : 249, "y" : 264 }, "c" : { "x" : 245, "y" : 257 }, "type" : "ARROW", "centre" : { "x" : 245, "y" : 257 } } } ] }, { "id" : 108251, "reactomeId" : 9947981, "displayName" : "GGPP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 372, "y" : 227 }, "minX" : 348, "maxX" : 398, "minY" : 211, "maxY" : 251, "prop" : { "x" : 348, "y" : 212, "width" : 49, "height" : 31 }, "textPosition" : { "x" : 351, "y" : 217 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 392, "y" : 217 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 392, "y" : 217 } } }, "connectors" : [ { "edgeId" : 108250, "type" : "INPUT", "segments" : [ { "from" : { "x" : 382, "y" : 246 }, "to" : { "x" : 389, "y" : 251 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 108253, "reactomeId" : 10727898, "displayName" : "Homologues of GGC-C588-GBP2", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 507, "y" : 283 }, "minX" : 451, "maxX" : 571, "minY" : 251, "maxY" : 385, "prop" : { "x" : 451, "y" : 272, "width" : 112, "height" : 23 }, "textPosition" : { "x" : 453, "y" : 266 }, "connectors" : [ { "edgeId" : 108275, "type" : "INPUT", "segments" : [ { "from" : { "x" : 514, "y" : 298 }, "to" : { "x" : 571, "y" : 385 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 108250, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 496, "y" : 269 }, "to" : { "x" : 477, "y" : 251 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 488, "y" : 267 }, "b" : { "x" : 496, "y" : 269 }, "c" : { "x" : 494, "y" : 261 }, "type" : "ARROW", "centre" : { "x" : 494, "y" : 261 } } } ] }, { "id" : 108252, "reactomeId" : 10727941, "displayName" : "Homologues of GBP2", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 382, "y" : 270 }, "minX" : 362, "maxX" : 402, "minY" : 251, "maxY" : 282, "prop" : { "x" : 362, "y" : 259, "width" : 40, "height" : 23 }, "textPosition" : { "x" : 364, "y" : 225 }, "connectors" : [ { "edgeId" : 108250, "type" : "INPUT", "segments" : [ { "from" : { "x" : 386, "y" : 256 }, "to" : { "x" : 389, "y" : 251 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 108255, "reactomeId" : 10727947, "displayName" : "FNTA:PGGT1B:Zn2+", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 432, "y" : 189 }, "minX" : 368, "maxX" : 679, "minY" : 172, "maxY" : 259, "prop" : { "x" : 368, "y" : 178, "width" : 128, "height" : 23 }, "textPosition" : { "x" : 384, "y" : 166 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 496, "y" : 178 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 496, "y" : 178 } } }, "connectors" : [ { "edgeId" : 108256, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 499, "y" : 189 }, "to" : { "x" : 674, "y" : 189 } }, { "from" : { "x" : 674, "y" : 189 }, "to" : { "x" : 675, "y" : 251 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 675, "y" : 255 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 675, "y" : 255 } } }, { "edgeId" : 108250, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 432, "y" : 204 }, "to" : { "x" : 433, "y" : 235 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 433, "y" : 239 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 433, "y" : 239 } } } ] }, { "id" : 108254, "reactomeId" : 111294, "displayName" : "PPi", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 509, "y" : 223 }, "minX" : 477, "maxX" : 527, "minY" : 207, "maxY" : 251, "prop" : { "x" : 492, "y" : 208, "width" : 34, "height" : 31 }, "textPosition" : { "x" : 495, "y" : 213 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 521, "y" : 213 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 521, "y" : 213 } } }, "connectors" : [ { "edgeId" : 108250, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 489, "y" : 237 }, "to" : { "x" : 477, "y" : 251 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 488, "y" : 245 }, "b" : { "x" : 489, "y" : 237 }, "c" : { "x" : 481, "y" : 240 }, "type" : "ARROW", "centre" : { "x" : 481, "y" : 240 } } } ] }, { "id" : 108257, "reactomeId" : 10728027, "displayName" : "Homologues of GBP5", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 603, "y" : 288 }, "minX" : 583, "maxX" : 649, "minY" : 268, "maxY" : 300, "prop" : { "x" : 583, "y" : 277, "width" : 40, "height" : 23 }, "textPosition" : { "x" : 585, "y" : 243 }, "connectors" : [ { "edgeId" : 108256, "type" : "INPUT", "segments" : [ { "from" : { "x" : 626, "y" : 279 }, "to" : { "x" : 649, "y" : 268 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 108259, "reactomeId" : 10728041, "displayName" : "Homologues of GGC-C583-GBP5", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 713, "y" : 297 }, "minX" : 657, "maxX" : 769, "minY" : 267, "maxY" : 309, "prop" : { "x" : 657, "y" : 286, "width" : 112, "height" : 23 }, "textPosition" : { "x" : 659, "y" : 280 }, "connectors" : [ { "edgeId" : 108256, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 707, "y" : 283 }, "to" : { "x" : 699, "y" : 267 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 700, "y" : 279 }, "b" : { "x" : 707, "y" : 283 }, "c" : { "x" : 707, "y" : 275 }, "type" : "ARROW", "centre" : { "x" : 707, "y" : 275 } } } ] }, { "id" : 108258, "reactomeId" : 9947981, "displayName" : "GGPP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 609, "y" : 244 }, "minX" : 585, "maxX" : 649, "minY" : 228, "maxY" : 268, "prop" : { "x" : 585, "y" : 229, "width" : 49, "height" : 31 }, "textPosition" : { "x" : 588, "y" : 234 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 629, "y" : 234 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 629, "y" : 234 } } }, "connectors" : [ { "edgeId" : 108256, "type" : "INPUT", "segments" : [ { "from" : { "x" : 637, "y" : 258 }, "to" : { "x" : 649, "y" : 268 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 108260, "reactomeId" : 111294, "displayName" : "PPi", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 743, "y" : 235 }, "minX" : 699, "maxX" : 761, "minY" : 219, "maxY" : 267, "prop" : { "x" : 726, "y" : 220, "width" : 34, "height" : 31 }, "textPosition" : { "x" : 729, "y" : 225 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 755, "y" : 225 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 755, "y" : 225 } } }, "connectors" : [ { "edgeId" : 108256, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 723, "y" : 247 }, "to" : { "x" : 699, "y" : 267 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 720, "y" : 255 }, "b" : { "x" : 723, "y" : 247 }, "c" : { "x" : 715, "y" : 248 }, "type" : "ARROW", "centre" : { "x" : 715, "y" : 248 } } } ] }, { "id" : 108263, "reactomeId" : 10727921, "displayName" : "S-farn-GBP1:GTP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 233, "y" : 334 }, "minX" : 178, "maxX" : 295, "minY" : 317, "maxY" : 389, "prop" : { "x" : 178, "y" : 323, "width" : 111, "height" : 23 }, "textPosition" : { "x" : 178, "y" : 325 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 289, "y" : 323 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 289, "y" : 323 } } }, "connectors" : [ { "edgeId" : 108261, "type" : "INPUT", "segments" : [ { "from" : { "x" : 239, "y" : 349 }, "to" : { "x" : 264, "y" : 389 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 245, "y" : 363 }, "b" : { "x" : 257, "y" : 375 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 251, "y" : 369 } } } }, { "edgeId" : 108302, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 108262, "reactomeId" : 6803081, "displayName" : "LPS", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 310, "y" : 372 }, "minX" : 264, "maxX" : 329, "minY" : 356, "maxY" : 389, "prop" : { "x" : 292, "y" : 357, "width" : 36, "height" : 31 }, "textPosition" : { "x" : 295, "y" : 362 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 323, "y" : 362 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 323, "y" : 362 } } }, "connectors" : [ { "edgeId" : 108261, "type" : "INPUT", "segments" : [ { "from" : { "x" : 289, "y" : 378 }, "to" : { "x" : 264, "y" : 389 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 108264, "reactomeId" : 10727923, "displayName" : "S-farn-GBP1:GTP:LPS", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 264, "y" : 453 }, "minX" : 207, "maxX" : 328, "minY" : 429, "maxY" : 472, "prop" : { "x" : 207, "y" : 435, "width" : 115, "height" : 37 }, "textPosition" : { "x" : 207, "y" : 437 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 322, "y" : 435 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 322, "y" : 435 } } }, "connectors" : [ { "edgeId" : 108261, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 108267, "reactomeId" : 29356, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 330, "y" : 665 }, "minX" : 309, "maxX" : 375, "minY" : 640, "maxY" : 681, "prop" : { "x" : 309, "y" : 650, "width" : 43, "height" : 31 }, "textPosition" : { "x" : 313, "y" : 655 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 347, "y" : 655 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 347, "y" : 655 } } }, "connectors" : [ { "edgeId" : 108265, "type" : "INPUT", "segments" : [ { "from" : { "x" : 355, "y" : 653 }, "to" : { "x" : 375, "y" : 640 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 359, "y" : 640 }, "b" : { "x" : 371, "y" : 652 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 365, "y" : 646 } } } } ], "trivial" : true }, { "id" : 108266, "reactomeId" : 10727878, "displayName" : "GBP1 oligomer:GDP:LPS", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 308, "y" : 608 }, "minX" : 245, "maxX" : 408, "minY" : 584, "maxY" : 640, "prop" : { "x" : 245, "y" : 590, "width" : 127, "height" : 37 }, "textPosition" : { "x" : 257, "y" : 592 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 372, "y" : 590 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 372, "y" : 590 } } }, "connectors" : [ { "edgeId" : 108265, "type" : "INPUT", "segments" : [ { "from" : { "x" : 346, "y" : 630 }, "to" : { "x" : 375, "y" : 640 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 108265, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 375, "y" : 614 }, "to" : { "x" : 403, "y" : 617 } }, { "from" : { "x" : 403, "y" : 617 }, "to" : { "x" : 404, "y" : 624 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 404, "y" : 628 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 404, "y" : 628 } } } ] }, { "id" : 108269, "reactomeId" : 29372, "displayName" : "Pi", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 454, "y" : 592 }, "minX" : 428, "maxX" : 469, "minY" : 576, "maxY" : 640, "prop" : { "x" : 441, "y" : 577, "width" : 27, "height" : 31 }, "textPosition" : { "x" : 445, "y" : 582 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 463, "y" : 582 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 463, "y" : 582 } } }, "connectors" : [ { "edgeId" : 108265, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 445, "y" : 611 }, "to" : { "x" : 428, "y" : 640 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 430, "y" : 619 }, "b" : { "x" : 442, "y" : 631 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 436, "y" : 625 } } }, "endShape" : { "a" : { "x" : 445, "y" : 619 }, "b" : { "x" : 445, "y" : 611 }, "c" : { "x" : 438, "y" : 615 }, "type" : "ARROW", "centre" : { "x" : 438, "y" : 615 } } } ] }, { "id" : 108268, "reactomeId" : 10727880, "displayName" : "GBP1 oligomer:GMP:LPS", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 526, "y" : 638 }, "minX" : 428, "maxX" : 596, "minY" : 614, "maxY" : 657, "prop" : { "x" : 462, "y" : 620, "width" : 128, "height" : 37 }, "textPosition" : { "x" : 474, "y" : 622 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 590, "y" : 620 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 590, "y" : 620 } } }, "connectors" : [ { "edgeId" : 108265, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 459, "y" : 639 }, "to" : { "x" : 428, "y" : 640 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 452, "y" : 643 }, "b" : { "x" : 459, "y" : 639 }, "c" : { "x" : 452, "y" : 635 }, "type" : "ARROW", "centre" : { "x" : 452, "y" : 635 } } }, { "edgeId" : 108271, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 108270, "reactomeId" : 70106, "displayName" : "H+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 442, "y" : 688 }, "minX" : 424, "maxX" : 461, "minY" : 640, "maxY" : 704, "prop" : { "x" : 424, "y" : 673, "width" : 36, "height" : 31 }, "textPosition" : { "x" : 428, "y" : 678 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 455, "y" : 678 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 455, "y" : 678 } } }, "connectors" : [ { "edgeId" : 108265, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 437, "y" : 670 }, "to" : { "x" : 428, "y" : 640 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 426, "y" : 649 }, "b" : { "x" : 438, "y" : 661 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 432, "y" : 655 } } }, "endShape" : { "a" : { "x" : 431, "y" : 665 }, "b" : { "x" : 437, "y" : 670 }, "c" : { "x" : 439, "y" : 662 }, "type" : "ARROW", "centre" : { "x" : 439, "y" : 662 } } } ], "trivial" : true }, { "id" : 108273, "reactomeId" : 6803081, "displayName" : "LPS", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 482, "y" : 735 }, "minX" : 464, "maxX" : 523, "minY" : 703, "maxY" : 751, "prop" : { "x" : 464, "y" : 720, "width" : 36, "height" : 31 }, "textPosition" : { "x" : 467, "y" : 725 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 495, "y" : 725 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 495, "y" : 725 } } }, "connectors" : [ { "edgeId" : 108271, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 503, "y" : 720 }, "to" : { "x" : 523, "y" : 703 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 506, "y" : 712 }, "b" : { "x" : 503, "y" : 720 }, "c" : { "x" : 511, "y" : 719 }, "type" : "ARROW", "centre" : { "x" : 511, "y" : 719 } } } ] }, { "id" : 108272, "reactomeId" : 113578, "displayName" : "GMP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 575, "y" : 736 }, "minX" : 523, "maxX" : 598, "minY" : 703, "maxY" : 752, "prop" : { "x" : 554, "y" : 721, "width" : 43, "height" : 31 }, "textPosition" : { "x" : 558, "y" : 726 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 592, "y" : 726 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 592, "y" : 726 } } }, "connectors" : [ { "edgeId" : 108271, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 551, "y" : 722 }, "to" : { "x" : 523, "y" : 703 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 543, "y" : 721 }, "b" : { "x" : 551, "y" : 722 }, "c" : { "x" : 548, "y" : 715 }, "type" : "ARROW", "centre" : { "x" : 548, "y" : 715 } } } ] }, { "id" : 108274, "reactomeId" : 10727874, "displayName" : "Homologues of S-farn-C589-GBP1", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 522, "y" : 781 }, "minX" : 461, "maxX" : 583, "minY" : 703, "maxY" : 793, "prop" : { "x" : 461, "y" : 770, "width" : 122, "height" : 23 }, "textPosition" : { "x" : 463, "y" : 764 }, "connectors" : [ { "edgeId" : 108271, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 522, "y" : 767 }, "to" : { "x" : 523, "y" : 703 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 518, "y" : 760 }, "b" : { "x" : 522, "y" : 767 }, "c" : { "x" : 526, "y" : 760 }, "type" : "ARROW", "centre" : { "x" : 526, "y" : 760 } } } ] }, { "id" : 108277, "reactomeId" : 10727860, "displayName" : "Homologues of GBP4", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 558, "y" : 437 }, "minX" : 538, "maxX" : 578, "minY" : 385, "maxY" : 449, "prop" : { "x" : 538, "y" : 426, "width" : 40, "height" : 23 }, "textPosition" : { "x" : 540, "y" : 392 }, "connectors" : [ { "edgeId" : 108275, "type" : "INPUT", "segments" : [ { "from" : { "x" : 560, "y" : 423 }, "to" : { "x" : 571, "y" : 385 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 108276, "reactomeId" : 29438, "displayName" : "GTP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 364, "y" : 304 }, "minX" : 320, "maxX" : 571, "minY" : 288, "maxY" : 385, "prop" : { "x" : 344, "y" : 289, "width" : 41, "height" : 31 }, "textPosition" : { "x" : 348, "y" : 294 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 380, "y" : 294 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 380, "y" : 294 } } }, "connectors" : [ { "edgeId" : 108302, "type" : "INPUT", "segments" : [ { "from" : { "x" : 341, "y" : 307 }, "to" : { "x" : 320, "y" : 312 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 108275, "type" : "INPUT", "segments" : [ { "from" : { "x" : 388, "y" : 312 }, "to" : { "x" : 571, "y" : 385 } } ], "stoichiometry" : { "value" : 3, "shape" : { "a" : { "x" : 473, "y" : 342 }, "b" : { "x" : 485, "y" : 354 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 479, "y" : 348 } } } } ] }, { "id" : 108279, "reactomeId" : 10727882, "displayName" : "LPS-bound GBP1 oligomer", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 434, "y" : 392 }, "minX" : 379, "maxX" : 571, "minY" : 374, "maxY" : 411, "prop" : { "x" : 379, "y" : 374, "width" : 111, "height" : 37 }, "textPosition" : { "x" : 377, "y" : 375 }, "connectors" : [ { "edgeId" : 108275, "type" : "INPUT", "segments" : [ { "from" : { "x" : 496, "y" : 389 }, "to" : { "x" : 571, "y" : 385 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 108278, "reactomeId" : 10727884, "displayName" : "gbp6.2", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 498, "y" : 442 }, "minX" : 478, "maxX" : 571, "minY" : 385, "maxY" : 454, "prop" : { "x" : 478, "y" : 431, "width" : 40, "height" : 23 }, "textPosition" : { "x" : 478, "y" : 425 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 518, "y" : 431 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 518, "y" : 431 } } }, "connectors" : [ { "edgeId" : 108275, "type" : "INPUT", "segments" : [ { "from" : { "x" : 512, "y" : 428 }, "to" : { "x" : 571, "y" : 385 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 108280, "reactomeId" : 10727900, "displayName" : "LPS:GBP1 oligomer:GBP2:GBP3:GBP4:GTP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 689, "y" : 385 }, "minX" : 629, "maxX" : 756, "minY" : 354, "maxY" : 442, "prop" : { "x" : 629, "y" : 360, "width" : 121, "height" : 51 }, "textPosition" : { "x" : 636, "y" : 362 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 750, "y" : 360 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 750, "y" : 360 } } }, "connectors" : [ { "edgeId" : 108275, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 108281, "type" : "INPUT", "segments" : [ { "from" : { "x" : 695, "y" : 414 }, "to" : { "x" : 703, "y" : 442 } } ], "stoichiometry" : { "value" : 3, "shape" : { "a" : { "x" : 693, "y" : 422 }, "b" : { "x" : 705, "y" : 434 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 699, "y" : 428 } } } } ] }, { "id" : 108283, "reactomeId" : 10727904, "displayName" : "LPS:(GBP1:GBP2:GBP3:GBP4) oligomer", "schemaClass" : "Polymer", "renderableClass" : "Entity", "position" : { "x" : 703, "y" : 568 }, "minX" : 650, "maxX" : 756, "minY" : 488, "maxY" : 594, "prop" : { "x" : 650, "y" : 543, "width" : 106, "height" : 51 }, "textPosition" : { "x" : 651, "y" : 544 }, "connectors" : [ { "edgeId" : 108281, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 703, "y" : 540 }, "to" : { "x" : 703, "y" : 488 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 699, "y" : 533 }, "b" : { "x" : 703, "y" : 540 }, "c" : { "x" : 707, "y" : 533 }, "type" : "ARROW", "centre" : { "x" : 707, "y" : 533 } } } ] }, { "id" : 108282, "reactomeId" : 29356, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 763, "y" : 434 }, "minX" : 703, "maxX" : 786, "minY" : 418, "maxY" : 450, "prop" : { "x" : 742, "y" : 419, "width" : 43, "height" : 31 }, "textPosition" : { "x" : 746, "y" : 424 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 780, "y" : 424 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 780, "y" : 424 } } }, "connectors" : [ { "edgeId" : 108281, "type" : "INPUT", "segments" : [ { "from" : { "x" : 739, "y" : 436 }, "to" : { "x" : 703, "y" : 442 } } ], "stoichiometry" : { "value" : 3, "shape" : { "a" : { "x" : 715, "y" : 433 }, "b" : { "x" : 727, "y" : 445 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 721, "y" : 439 } } } } ], "trivial" : true }, { "id" : 108285, "reactomeId" : 70106, "displayName" : "H+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 646, "y" : 513 }, "minX" : 628, "maxX" : 703, "minY" : 488, "maxY" : 529, "prop" : { "x" : 628, "y" : 498, "width" : 36, "height" : 31 }, "textPosition" : { "x" : 632, "y" : 503 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 659, "y" : 503 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 659, "y" : 503 } } }, "connectors" : [ { "edgeId" : 108281, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 667, "y" : 505 }, "to" : { "x" : 703, "y" : 488 } } ], "stoichiometry" : { "value" : 3, "shape" : { "a" : { "x" : 679, "y" : 490 }, "b" : { "x" : 691, "y" : 502 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 685, "y" : 496 } } }, "endShape" : { "a" : { "x" : 672, "y" : 498 }, "b" : { "x" : 667, "y" : 505 }, "c" : { "x" : 675, "y" : 506 }, "type" : "ARROW", "centre" : { "x" : 675, "y" : 506 } } } ], "trivial" : true }, { "id" : 108284, "reactomeId" : 29372, "displayName" : "Pi", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 757, "y" : 507 }, "minX" : 703, "maxX" : 772, "minY" : 488, "maxY" : 523, "prop" : { "x" : 744, "y" : 492, "width" : 27, "height" : 31 }, "textPosition" : { "x" : 748, "y" : 497 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 766, "y" : 497 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 766, "y" : 497 } } }, "connectors" : [ { "edgeId" : 108281, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 741, "y" : 502 }, "to" : { "x" : 703, "y" : 488 } } ], "stoichiometry" : { "value" : 3, "shape" : { "a" : { "x" : 716, "y" : 489 }, "b" : { "x" : 728, "y" : 501 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 722, "y" : 495 } } }, "endShape" : { "a" : { "x" : 733, "y" : 503 }, "b" : { "x" : 741, "y" : 502 }, "c" : { "x" : 736, "y" : 496 }, "type" : "ARROW", "centre" : { "x" : 736, "y" : 496 } } } ] }, { "id" : 108287, "reactomeId" : 10728063, "displayName" : "GGC-GBP2, GGC-GBP5", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 575, "y" : 134 }, "minX" : 518, "maxX" : 632, "minY" : 76, "maxY" : 153, "prop" : { "x" : 518, "y" : 116, "width" : 114, "height" : 37 }, "textPosition" : { "x" : 520, "y" : 117 }, "connectors" : [ { "edgeId" : 108286, "type" : "INPUT", "segments" : [ { "from" : { "x" : 577, "y" : 110 }, "to" : { "x" : 584, "y" : 76 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 574, "y" : 87 }, "b" : { "x" : 586, "y" : 99 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 580, "y" : 93 } } } } ] } ], "edges" : [ { "id" : 108256, "reactomeId" : 10728043, "displayName" : "FNTA:PGGT1B geranylgeranylates GBP5", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 675, "y" : 267 }, "minX" : 649, "maxX" : 699, "minY" : 261, "maxY" : 273, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 649, "y" : 268 }, "to" : { "x" : 675, "y" : 267 } }, { "from" : { "x" : 675, "y" : 267 }, "to" : { "x" : 699, "y" : 267 } } ], "reactionShape" : { "a" : { "x" : 669, "y" : 261 }, "b" : { "x" : 681, "y" : 273 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 675, "y" : 267 } }, "inputs" : [ { "id" : 108257, "points" : [ { "x" : 626, "y" : 279 } ] }, { "id" : 108258, "points" : [ { "x" : 637, "y" : 258 } ] } ], "outputs" : [ { "id" : 108259, "points" : [ { "x" : 707, "y" : 283 } ] }, { "id" : 108260, "points" : [ { "x" : 723, "y" : 247 } ] } ], "catalysts" : [ { "id" : 108255, "points" : [ { "x" : 499, "y" : 189 }, { "x" : 674, "y" : 189 } ] } ] }, { "id" : 108291, "reactomeId" : 10728148, "displayName" : "GBP1 binds actin", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 346, "y" : 150 }, "minX" : 323, "maxX" : 374, "minY" : 144, "maxY" : 156, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 323, "y" : 150 }, "to" : { "x" : 346, "y" : 150 } }, { "from" : { "x" : 346, "y" : 150 }, "to" : { "x" : 374, "y" : 149 } } ], "endShape" : { "a" : { "x" : 367, "y" : 153 }, "b" : { "x" : 374, "y" : 149 }, "c" : { "x" : 367, "y" : 145 }, "type" : "ARROW", "centre" : { "x" : 367, "y" : 145 } }, "reactionShape" : { "c" : { "x" : 346, "y" : 150 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 346, "y" : 150 } }, "inputs" : [ { "id" : 108292, "points" : [ { "x" : 302, "y" : 132 } ] }, { "id" : 108248, "points" : [ { "x" : 271, "y" : 264 } ] } ], "outputs" : [ { "id" : 108293 } ] }, { "id" : 108261, "reactomeId" : 10727925, "displayName" : "GBP1:GTP binds LPS on the bacterial surface", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 263, "y" : 408 }, "minX" : 257, "maxX" : 269, "minY" : 389, "maxY" : 432, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 264, "y" : 389 }, "to" : { "x" : 263, "y" : 408 } }, { "from" : { "x" : 263, "y" : 408 }, "to" : { "x" : 263, "y" : 432 } } ], "endShape" : { "a" : { "x" : 259, "y" : 425 }, "b" : { "x" : 263, "y" : 432 }, "c" : { "x" : 267, "y" : 425 }, "type" : "ARROW", "centre" : { "x" : 267, "y" : 425 } }, "reactionShape" : { "c" : { "x" : 263, "y" : 408 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 263, "y" : 408 } }, "inputs" : [ { "id" : 108262, "points" : [ { "x" : 289, "y" : 378 } ] }, { "id" : 108263, "points" : [ { "x" : 239, "y" : 349 } ], "stoichiometry" : 2 } ], "outputs" : [ { "id" : 108264 } ] }, { "id" : 108294, "reactomeId" : 10728170, "displayName" : "CASP1 cleaves GBP1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 65, "y" : 155 }, "minX" : 59, "maxX" : 96, "minY" : 149, "maxY" : 230, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 67, "y" : 230 }, "to" : { "x" : 65, "y" : 155 } }, { "from" : { "x" : 65, "y" : 155 }, "to" : { "x" : 96, "y" : 155 } } ], "reactionShape" : { "a" : { "x" : 59, "y" : 149 }, "b" : { "x" : 71, "y" : 161 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 65, "y" : 155 } }, "inputs" : [ { "id" : 108245 } ], "outputs" : [ { "id" : 108295, "points" : [ { "x" : 151, "y" : 129 } ] }, { "id" : 108296, "points" : [ { "x" : 139, "y" : 154 } ] } ], "catalysts" : [ { "id" : 108297, "points" : [ { "x" : 85, "y" : 81 }, { "x" : 65, "y" : 87 } ] } ] }, { "id" : 108265, "reactomeId" : 10727919, "displayName" : "GBP1 hydrolyzes GDP", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 406, "y" : 640 }, "minX" : 375, "maxX" : 428, "minY" : 634, "maxY" : 646, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 375, "y" : 640 }, "to" : { "x" : 406, "y" : 640 } }, { "from" : { "x" : 406, "y" : 640 }, "to" : { "x" : 428, "y" : 640 } } ], "reactionShape" : { "a" : { "x" : 400, "y" : 634 }, "b" : { "x" : 412, "y" : 646 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 406, "y" : 640 } }, "inputs" : [ { "id" : 108266, "points" : [ { "x" : 346, "y" : 630 } ] }, { "id" : 108267, "points" : [ { "x" : 355, "y" : 653 } ], "stoichiometry" : 2 } ], "outputs" : [ { "id" : 108268, "points" : [ { "x" : 459, "y" : 639 } ] }, { "id" : 108269, "points" : [ { "x" : 445, "y" : 611 } ], "stoichiometry" : 2 }, { "id" : 108270, "points" : [ { "x" : 437, "y" : 670 } ], "stoichiometry" : 2 } ], "catalysts" : [ { "id" : 108266, "points" : [ { "x" : 375, "y" : 614 }, { "x" : 403, "y" : 617 } ] } ] }, { "id" : 108298, "reactomeId" : 10728075, "displayName" : "SFN binds S-farn-C589,p-S156,T590-GBP1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 96, "y" : 487 }, "minX" : 90, "maxX" : 102, "minY" : 467, "maxY" : 516, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 96, "y" : 467 }, "to" : { "x" : 96, "y" : 487 } }, { "from" : { "x" : 96, "y" : 487 }, "to" : { "x" : 96, "y" : 516 } } ], "endShape" : { "a" : { "x" : 92, "y" : 509 }, "b" : { "x" : 96, "y" : 516 }, "c" : { "x" : 100, "y" : 509 }, "type" : "ARROW", "centre" : { "x" : 100, "y" : 509 } }, "reactionShape" : { "c" : { "x" : 96, "y" : 487 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 96, "y" : 487 } }, "inputs" : [ { "id" : 108299, "points" : [ { "x" : 75, "y" : 415 } ] }, { "id" : 108300, "points" : [ { "x" : 120, "y" : 453 } ] } ], "outputs" : [ { "id" : 108301 } ] }, { "id" : 108271, "reactomeId" : 10728008, "displayName" : "GMP dissociates from the GBP1 oligomer", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 524, "y" : 681 }, "minX" : 518, "maxX" : 530, "minY" : 660, "maxY" : 703, "reactionType" : "dissociation", "segments" : [ { "from" : { "x" : 525, "y" : 660 }, "to" : { "x" : 524, "y" : 681 } }, { "from" : { "x" : 524, "y" : 681 }, "to" : { "x" : 523, "y" : 703 } } ], "reactionShape" : { "c" : { "x" : 524, "y" : 681 }, "r" : 5, "r1" : 3, "type" : "DOUBLE_CIRCLE", "empty" : true, "centre" : { "x" : 524, "y" : 681 } }, "inputs" : [ { "id" : 108268 } ], "outputs" : [ { "id" : 108272, "points" : [ { "x" : 551, "y" : 722 } ] }, { "id" : 108273, "points" : [ { "x" : 503, "y" : 720 } ] }, { "id" : 108274, "points" : [ { "x" : 522, "y" : 767 } ] } ] }, { "id" : 108302, "reactomeId" : 10728196, "displayName" : "GBP1 binds GTP", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 320, "y" : 334 }, "minX" : 292, "maxX" : 326, "minY" : 312, "maxY" : 340, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 320, "y" : 312 }, "to" : { "x" : 320, "y" : 334 } }, { "from" : { "x" : 320, "y" : 334 }, "to" : { "x" : 292, "y" : 334 } } ], "endShape" : { "a" : { "x" : 299, "y" : 330 }, "b" : { "x" : 292, "y" : 334 }, "c" : { "x" : 299, "y" : 338 }, "type" : "ARROW", "centre" : { "x" : 299, "y" : 338 } }, "reactionShape" : { "c" : { "x" : 320, "y" : 334 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 320, "y" : 334 } }, "inputs" : [ { "id" : 108276, "points" : [ { "x" : 341, "y" : 307 } ] }, { "id" : 108248, "points" : [ { "x" : 284, "y" : 293 } ] } ], "outputs" : [ { "id" : 108263 } ] }, { "id" : 108275, "reactomeId" : 10727931, "displayName" : "GBP2, GBP3, GBP4 bind to GBP1 oligomer on the bacterial surface", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 595, "y" : 385 }, "minX" : 571, "maxX" : 626, "minY" : 379, "maxY" : 391, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 571, "y" : 385 }, "to" : { "x" : 595, "y" : 385 } }, { "from" : { "x" : 595, "y" : 385 }, "to" : { "x" : 626, "y" : 385 } } ], "endShape" : { "a" : { "x" : 619, "y" : 389 }, "b" : { "x" : 626, "y" : 385 }, "c" : { "x" : 619, "y" : 381 }, "type" : "ARROW", "centre" : { "x" : 619, "y" : 381 } }, "reactionShape" : { "c" : { "x" : 595, "y" : 385 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 595, "y" : 385 } }, "inputs" : [ { "id" : 108276, "points" : [ { "x" : 388, "y" : 312 } ], "stoichiometry" : 3 }, { "id" : 108277, "points" : [ { "x" : 560, "y" : 423 } ] }, { "id" : 108253, "points" : [ { "x" : 514, "y" : 298 } ] }, { "id" : 108278, "points" : [ { "x" : 512, "y" : 428 } ] }, { "id" : 108279, "points" : [ { "x" : 496, "y" : 389 } ] } ], "outputs" : [ { "id" : 108280 } ] }, { "id" : 108244, "reactomeId" : 10727952, "displayName" : "FNTA:FNTB transfers farnesyl to GBP1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 171, "y" : 243 }, "minX" : 127, "maxX" : 215, "minY" : 237, "maxY" : 249, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 127, "y" : 243 }, "to" : { "x" : 171, "y" : 243 } }, { "from" : { "x" : 171, "y" : 243 }, "to" : { "x" : 215, "y" : 243 } } ], "reactionShape" : { "a" : { "x" : 165, "y" : 237 }, "b" : { "x" : 177, "y" : 249 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 171, "y" : 243 } }, "inputs" : [ { "id" : 108245, "points" : [ { "x" : 91, "y" : 243 } ] }, { "id" : 108246, "points" : [ { "x" : 115, "y" : 229 } ] } ], "outputs" : [ { "id" : 108247, "points" : [ { "x" : 226, "y" : 230 } ] }, { "id" : 108248, "points" : [ { "x" : 249, "y" : 264 } ] } ], "catalysts" : [ { "id" : 108249, "points" : [ { "x" : 171, "y" : 215 } ] } ] }, { "id" : 108281, "reactomeId" : 10727906, "displayName" : "GBP1:GBP2:GBP3:GBP4 forms higher-order structures", "schemaClass" : "Polymerisation", "renderableClass" : "Reaction", "position" : { "x" : 703, "y" : 466 }, "minX" : 697, "maxX" : 709, "minY" : 442, "maxY" : 488, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 703, "y" : 442 }, "to" : { "x" : 703, "y" : 466 } }, { "from" : { "x" : 703, "y" : 466 }, "to" : { "x" : 703, "y" : 488 } } ], "reactionShape" : { "c" : { "x" : 703, "y" : 466 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 703, "y" : 466 } }, "inputs" : [ { "id" : 108280, "points" : [ { "x" : 695, "y" : 414 } ], "stoichiometry" : 3 }, { "id" : 108282, "points" : [ { "x" : 739, "y" : 436 } ], "stoichiometry" : 3 } ], "outputs" : [ { "id" : 108283, "points" : [ { "x" : 703, "y" : 540 } ] }, { "id" : 108284, "points" : [ { "x" : 741, "y" : 502 } ], "stoichiometry" : 3 }, { "id" : 108285, "points" : [ { "x" : 667, "y" : 505 } ], "stoichiometry" : 3 } ] }, { "id" : 108250, "reactomeId" : 10727950, "displayName" : "FNTA:PGGT1B geranylgeranylates GBP2", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 433, "y" : 251 }, "minX" : 389, "maxX" : 477, "minY" : 245, "maxY" : 257, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 389, "y" : 251 }, "to" : { "x" : 433, "y" : 251 } }, { "from" : { "x" : 433, "y" : 251 }, "to" : { "x" : 477, "y" : 251 } } ], "reactionShape" : { "a" : { "x" : 427, "y" : 245 }, "b" : { "x" : 439, "y" : 257 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 433, "y" : 251 } }, "inputs" : [ { "id" : 108251, "points" : [ { "x" : 382, "y" : 246 } ] }, { "id" : 108252, "points" : [ { "x" : 386, "y" : 256 } ] } ], "outputs" : [ { "id" : 108253, "points" : [ { "x" : 496, "y" : 269 } ] }, { "id" : 108254, "points" : [ { "x" : 489, "y" : 237 } ] } ], "catalysts" : [ { "id" : 108255, "points" : [ { "x" : 432, "y" : 204 } ] } ] }, { "id" : 108286, "reactomeId" : 10728071, "displayName" : "GGC-GBP2, GGC-GBP5 bind furin", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 611, "y" : 76 }, "minX" : 584, "maxX" : 643, "minY" : 70, "maxY" : 82, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 584, "y" : 76 }, "to" : { "x" : 611, "y" : 76 } }, { "from" : { "x" : 611, "y" : 76 }, "to" : { "x" : 643, "y" : 76 } } ], "endShape" : { "a" : { "x" : 636, "y" : 80 }, "b" : { "x" : 643, "y" : 76 }, "c" : { "x" : 636, "y" : 72 }, "type" : "ARROW", "centre" : { "x" : 636, "y" : 72 } }, "reactionShape" : { "a" : { "x" : 605, "y" : 70 }, "b" : { "x" : 617, "y" : 82 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 611, "y" : 76 } }, "inputs" : [ { "id" : 108287, "points" : [ { "x" : 577, "y" : 110 } ], "stoichiometry" : 2 }, { "id" : 108288, "points" : [ { "x" : 527, "y" : 76 } ], "stoichiometry" : 2 }, { "id" : 108289, "points" : [ { "x" : 565, "y" : 56 } ], "stoichiometry" : 2 } ], "outputs" : [ { "id" : 108290 } ] } ], "compartments" : [ { "id" : 108303, "reactomeId" : 70101, "displayName" : "cytosol", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 402, "y" : 415 }, "minX" : 0, "maxX" : 804, "minY" : 0, "maxY" : 831, "prop" : { "x" : 0, "y" : 0, "width" : 804, "height" : 831 }, "textPosition" : { "x" : 712, "y" : 13 }, "insets" : { "x" : 10, "y" : 10, "width" : 784, "height" : 811 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 108245, 108246, 108248, 108247, 108249, 108251, 108252, 108253, 108255, 108254, 108258, 108257, 108259, 108260, 108276, 108262, 108264, 108266, 108268, 108270, 108269, 108272, 108279, 108309, 108310, 108277, 108278, 108280, 108283, 108312, 108287, 108289, 108288, 108290, 108311, 108285, 108284, 108299, 108300, 108301, 108292, 108293, 108296, 108295, 108297, 108273, 108274, 108244, 108250, 108256, 108261, 108265, 108267, 108271, 108275, 108281, 108282, 108286, 108291, 108294, 108298, 108263, 108302, 108313 ] } ], "notes" : [ ], "links" : [ { "id" : 108309, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 393, "y" : 590 }, "minX" : 375, "maxX" : 430, "minY" : 417, "maxY" : 596, "segments" : [ { "from" : { "x" : 375, "y" : 594 }, "to" : { "x" : 393, "y" : 590 } }, { "from" : { "x" : 393, "y" : 590 }, "to" : { "x" : 430, "y" : 417 } } ], "reactionShape" : { "a" : { "x" : 387, "y" : 584 }, "b" : { "x" : 399, "y" : 596 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 393, "y" : 590 } }, "inputs" : [ { "id" : 108266 } ], "outputs" : [ { "id" : 108279 } ] }, { "id" : 108311, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 770, "y" : 203 }, "minX" : 638, "maxX" : 776, "minY" : 134, "maxY" : 283, "segments" : [ { "from" : { "x" : 740, "y" : 283 }, "to" : { "x" : 771, "y" : 273 } }, { "from" : { "x" : 771, "y" : 273 }, "to" : { "x" : 769, "y" : 134 } }, { "from" : { "x" : 769, "y" : 134 }, "to" : { "x" : 638, "y" : 134 } } ], "reactionShape" : { "a" : { "x" : 764, "y" : 197 }, "b" : { "x" : 776, "y" : 209 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 770, "y" : 203 } }, "inputs" : [ { "id" : 108259 } ], "outputs" : [ { "id" : 108287 } ] }, { "id" : 108310, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 479, "y" : 517 }, "minX" : 440, "maxX" : 518, "minY" : 417, "maxY" : 617, "segments" : [ { "from" : { "x" : 518, "y" : 617 }, "to" : { "x" : 440, "y" : 417 } } ], "reactionShape" : { "a" : { "x" : 473, "y" : 511 }, "b" : { "x" : 485, "y" : 523 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 479, "y" : 517 } }, "inputs" : [ { "id" : 108268 } ], "outputs" : [ { "id" : 108279 } ] }, { "id" : 108312, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 578, "y" : 173 }, "minX" : 514, "maxX" : 584, "minY" : 159, "maxY" : 269, "segments" : [ { "from" : { "x" : 514, "y" : 269 }, "to" : { "x" : 578, "y" : 173 } }, { "from" : { "x" : 578, "y" : 173 }, "to" : { "x" : 576, "y" : 159 } } ], "reactionShape" : { "a" : { "x" : 572, "y" : 167 }, "b" : { "x" : 584, "y" : 179 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 578, "y" : 173 } }, "inputs" : [ { "id" : 108253 } ], "outputs" : [ { "id" : 108287 } ] } ], "shadows" : [ { "id" : 108313, "reactomeId" : 10731580, "displayName" : "Regulation of GBP-mediated host defense", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 128, "y" : 305 }, "minX" : 1, "maxX" : 255, "minY" : 45, "maxY" : 566, "prop" : { "x" : 1, "y" : 45, "width" : 254, "height" : 521 }, "points" : [ { "x" : 1, "y" : 45 }, { "x" : 255, "y" : 45 }, { "x" : 255, "y" : 566 }, { "x" : 1, "y" : 566 } ], "colour" : "#4684ee" } ], "minX" : 0, "maxX" : 804, "minY" : 0, "maxY" : 831, "disease" : false }