{
  "dbId" : 10731468,
  "stId" : "R-XTR-9856649",
  "speciesName" : "Xenopus tropicalis",
  "nodes" : [ {
    "dbId" : 10725155,
    "stId" : "R-XTR-9824664",
    "displayName" : "mitf [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 205621,
    "diagramIds" : [ 20231 ],
    "identifier" : "A4IID0",
    "standardIdentifier" : "uniprot:A4IID0",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "mitf" ],
    "parents" : [ 10726907, 10725209 ],
    "children" : [ ]
  }, {
    "dbId" : 10725158,
    "stId" : "R-XTR-9824575",
    "displayName" : "phospho-mitf [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 205621,
    "diagramIds" : [ 20232 ],
    "identifier" : "A4IID0",
    "standardIdentifier" : "uniprot:A4IID0",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "mitf" ],
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10725097,
    "stId" : "R-XTR-9824578",
    "displayName" : "phospho-sox10 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 205621,
    "diagramIds" : [ 20226 ],
    "identifier" : "A4IIJ8",
    "standardIdentifier" : "uniprot:A4IIJ8",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "sox10" ],
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10657641,
    "stId" : "R-XTR-109853",
    "displayName" : "phospho-p-T185,Y187-MAPK1 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 205621,
    "identifier" : "Q28H11",
    "standardIdentifier" : "uniprot:Q28H11",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10661704 ],
    "children" : [ ]
  }, {
    "dbId" : 10725166,
    "stId" : "R-XTR-9824974",
    "displayName" : "p-S69,73 MITF-M:XPO1 [nucleoplasm]",
    "schemaClass" : "Complex",
    "speciesId" : 205621,
    "diagramIds" : [ 20250 ],
    "parents" : [ ],
    "children" : [ 10725164, 10661334 ]
  }, {
    "dbId" : 10725164,
    "stId" : "R-XTR-9824962",
    "displayName" : "phospho-mitf [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 205621,
    "diagramIds" : [ 20248 ],
    "identifier" : "A4IID0",
    "standardIdentifier" : "uniprot:A4IID0",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "mitf" ],
    "parents" : [ 10725166 ],
    "children" : [ ]
  }, {
    "dbId" : 10725170,
    "stId" : "R-XTR-9824966",
    "displayName" : "phospho-mitf [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 205621,
    "diagramIds" : [ 20253 ],
    "identifier" : "A4IID0",
    "standardIdentifier" : "uniprot:A4IID0",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "mitf" ],
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10666739,
    "stId" : "R-XTR-708330",
    "displayName" : "kitlg [extracellular region]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 205621,
    "identifier" : "B4F6K4",
    "standardIdentifier" : "uniprot:B4F6K4",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "kitlg" ],
    "parents" : [ 10666741 ],
    "children" : [ ]
  }, {
    "dbId" : 10725175,
    "stId" : "R-XTR-9824967",
    "displayName" : "phospho-mitf [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 205621,
    "diagramIds" : [ 20238 ],
    "identifier" : "A4IID0",
    "standardIdentifier" : "uniprot:A4IID0",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "mitf" ],
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10678646,
    "stId" : "R-XTR-381325",
    "displayName" : "ep300 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 205621,
    "diagramIds" : [ 20261 ],
    "identifier" : "F7DX95",
    "standardIdentifier" : "uniprot:F7DX95",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "ep300" ],
    "parents" : [ 10726907 ],
    "children" : [ ]
  }, {
    "dbId" : 10665655,
    "stId" : "R-XTR-3247784",
    "displayName" : "wnt3a [extracellular region]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 205621,
    "diagramIds" : [ 20246 ],
    "identifier" : "A0A803J6C2",
    "standardIdentifier" : "uniprot:A0A803J6C2",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "wnt3a" ],
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10666741,
    "stId" : "R-XTR-1433307",
    "displayName" : "sSCF dimer [extracellular region]",
    "schemaClass" : "Complex",
    "speciesId" : 205621,
    "parents" : [ 10666764 ],
    "children" : [ 10666739 ]
  }, {
    "dbId" : 10726907,
    "stId" : "R-XTR-9926393",
    "displayName" : "MITF-M:CREBBP,EP300 [nucleoplasm]",
    "schemaClass" : "Complex",
    "speciesId" : 205621,
    "diagramIds" : [ 20262 ],
    "parents" : [ ],
    "children" : [ 10678646, 10725155 ]
  }, {
    "dbId" : 10725183,
    "stId" : "R-XTR-9824963",
    "displayName" : "phospho-mitf [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 205621,
    "diagramIds" : [ 20244 ],
    "identifier" : "A4IID0",
    "standardIdentifier" : "uniprot:A4IID0",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "mitf" ],
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10659210,
    "stId" : "R-XTR-165539",
    "displayName" : "xpo1 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 205621,
    "diagramIds" : [ 20252 ],
    "identifier" : "A0A8J0QZP3",
    "standardIdentifier" : "uniprot:A0A8J0QZP3",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "xpo1" ],
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10721291,
    "stId" : "R-XTR-9613639",
    "displayName" : "sox10 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 205621,
    "diagramIds" : [ 20224 ],
    "identifier" : "A4IIJ8",
    "standardIdentifier" : "uniprot:A4IIJ8",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "sox10" ],
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10666762,
    "stId" : "R-XTR-205207",
    "displayName" : "phospho-p-7Y-KIT [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 205621,
    "identifier" : "B4F6V0",
    "standardIdentifier" : "uniprot:B4F6V0",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10666764 ],
    "children" : [ ]
  }, {
    "dbId" : 10724106,
    "stId" : "R-XTR-2022823",
    "displayName" : "GSK3B [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 205621,
    "diagramIds" : [ 20245 ],
    "identifier" : "A0A8J0T0Z2",
    "standardIdentifier" : "uniprot:A0A8J0T0Z2",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10661704,
    "stId" : "R-XTR-109855",
    "displayName" : "p-T185,Y187 MAPK1 dimer [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 205621,
    "diagramIds" : [ 20228, 20234 ],
    "parents" : [ ],
    "children" : [ 10657641 ]
  }, {
    "dbId" : 10725199,
    "stId" : "R-XTR-9825679",
    "displayName" : "hint1 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 205621,
    "identifier" : "Q28FL4",
    "standardIdentifier" : "uniprot:Q28FL4",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "hint1" ],
    "parents" : [ 10725201 ],
    "children" : [ ]
  }, {
    "dbId" : 29358,
    "stId" : "R-ALL-29358",
    "displayName" : "ATP [nucleoplasm]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 20225, 20258, 20242, 20230, 20237 ],
    "identifier" : "30616",
    "standardIdentifier" : "chebi:30616",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10666764,
    "stId" : "R-XTR-205310",
    "displayName" : "p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 205621,
    "diagramIds" : [ 20235 ],
    "parents" : [ ],
    "children" : [ 10666762, 10666741 ]
  }, {
    "dbId" : 113582,
    "stId" : "R-ALL-113582",
    "displayName" : "ADP [nucleoplasm]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 20259, 20227, 20243, 20233, 20239 ],
    "identifier" : "456216",
    "standardIdentifier" : "chebi:456216",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10725201,
    "stId" : "R-XTR-9825721",
    "displayName" : "HINT1 dimer [nucleoplasm]",
    "schemaClass" : "Complex",
    "speciesId" : 205621,
    "diagramIds" : [ 20255 ],
    "parents" : [ 10725209 ],
    "children" : [ 10725199 ]
  }, {
    "dbId" : 10661334,
    "stId" : "R-XTR-165529",
    "displayName" : "xpo1 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 205621,
    "diagramIds" : [ 20249 ],
    "identifier" : "A0A8J0QZP3",
    "standardIdentifier" : "uniprot:A0A8J0QZP3",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "xpo1" ],
    "parents" : [ 10725166 ],
    "children" : [ ]
  }, {
    "dbId" : 10725209,
    "stId" : "R-XTR-9825723",
    "displayName" : "MITF-M:HINT1 dimer [nucleoplasm]",
    "schemaClass" : "Complex",
    "speciesId" : 205621,
    "diagramIds" : [ 20256 ],
    "parents" : [ ],
    "children" : [ 10725201, 10725155 ]
  }, {
    "dbId" : 10664735,
    "stId" : "R-XTR-199829",
    "displayName" : "phospho-p-4S,T359,T573-RPS6KA1 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 205621,
    "diagramIds" : [ 20240 ],
    "identifier" : "A0A6I8SXX2",
    "standardIdentifier" : "uniprot:A0A6I8SXX2",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ ],
    "children" : [ ]
  } ],
  "edges" : [ {
    "dbId" : 10725185,
    "stId" : "R-XTR-9824995",
    "displayName" : "GSK3B phosphorylates p-S409 MITF-M at S397, S401 and S405",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10725178 ],
    "inputs" : [ 29358, 10725175 ],
    "outputs" : [ 113582, 10725183 ],
    "catalysts" : [ 10724106 ],
    "efs" : [ ],
    "inhibitors" : [ 10665655 ],
    "diagramIds" : [ 20241 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10725168,
    "stId" : "R-XTR-9824979",
    "displayName" : "XPO1 binds p-S69,73 MITF-M",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10725188 ],
    "following" : [ 10725172 ],
    "inputs" : [ 10725164, 10661334 ],
    "outputs" : [ 10725166 ],
    "efs" : [ ],
    "diagramIds" : [ 20247 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10725188,
    "stId" : "R-XTR-9824999",
    "displayName" : "GSK3B phosphorylates p-S73 MITF-M at residue S69",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10725160 ],
    "following" : [ 10725168 ],
    "inputs" : [ 29358, 10725158 ],
    "outputs" : [ 113582, 10725164 ],
    "catalysts" : [ 10724106 ],
    "efs" : [ ],
    "diagramIds" : [ 20257 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10725172,
    "stId" : "R-XTR-9824986",
    "displayName" : "XPO1-dependent export of p-S69,S73 MITF-M",
    "schemaClass" : "BlackBoxEvent",
    "speciesId" : 0,
    "preceding" : [ 10725168 ],
    "inputs" : [ 10725166 ],
    "outputs" : [ 10659210, 10725170 ],
    "efs" : [ ],
    "diagramIds" : [ 20251 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10725099,
    "stId" : "R-XTR-9824582",
    "displayName" : "MAPK1 phosphorylates SOX10",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 29358, 10721291 ],
    "outputs" : [ 113582, 10725097 ],
    "catalysts" : [ 10661704 ],
    "efs" : [ ],
    "diagramIds" : [ 20223 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10725211,
    "stId" : "R-XTR-9825751",
    "displayName" : "HINT1 binds MITF-M",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 10725201, 10725155 ],
    "outputs" : [ 10725209 ],
    "efs" : [ ],
    "diagramIds" : [ 20254 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10725178,
    "stId" : "R-XTR-9824994",
    "displayName" : "RPS6KA1-dependent phosphorylation of MITF-M",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "following" : [ 10725185 ],
    "inputs" : [ 29358, 10725155 ],
    "outputs" : [ 113582, 10725175 ],
    "catalysts" : [ 10664735 ],
    "efs" : [ ],
    "activators" : [ 10666764 ],
    "diagramIds" : [ 20236 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10725160,
    "stId" : "R-XTR-9824977",
    "displayName" : "MAPK1-dependent phosphorylation of MITF-M",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "following" : [ 10725188 ],
    "inputs" : [ 29358, 10725155 ],
    "outputs" : [ 113582, 10725158 ],
    "catalysts" : [ 10661704 ],
    "efs" : [ ],
    "activators" : [ 10666764 ],
    "diagramIds" : [ 20229 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10726909,
    "stId" : "R-XTR-9926478",
    "displayName" : "MITF-M binds CREBBP,EP300",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 10678646, 10725155 ],
    "outputs" : [ 10726907 ],
    "efs" : [ ],
    "diagramIds" : [ 20260 ],
    "entityFunctionalStatus" : [ ]
  } ]
}