{
  "dbId" : 10730998,
  "stId" : "R-XTR-5686938",
  "speciesName" : "Xenopus tropicalis",
  "nodes" : [ {
    "dbId" : 10660838,
    "stId" : "R-XTR-166010",
    "displayName" : "bpi5 [extracellular region]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 205621,
    "identifier" : "A0A6I8QHS4",
    "standardIdentifier" : "uniprot:A0A6I8QHS4",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "bpi5" ],
    "parents" : [ 10660848 ],
    "children" : [ ]
  }, {
    "dbId" : 10714468,
    "stId" : "R-XTR-8869676",
    "displayName" : "LBP:oxPL [extracellular region]",
    "schemaClass" : "Complex",
    "speciesId" : 205621,
    "diagramIds" : [ 133721 ],
    "parents" : [ ],
    "children" : [ 2186967, 10660848 ]
  }, {
    "dbId" : 10660842,
    "stId" : "R-XTR-166010-2",
    "displayName" : "LOC116408073 [extracellular region]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 205621,
    "identifier" : "A0A803J315",
    "standardIdentifier" : "uniprot:A0A803J315",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "LOC116408073" ],
    "parents" : [ 10660848 ],
    "children" : [ ]
  }, {
    "dbId" : 10729128,
    "stId" : "R-XTR-975155",
    "displayName" : "MyD88 dependent cascade initiated on endosome",
    "schemaClass" : "Pathway",
    "speciesId" : 205621,
    "diagramIds" : [ 133733 ]
  }, {
    "dbId" : 10658217,
    "stId" : "R-XTR-9647689",
    "displayName" : "gsdme [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 205621,
    "identifier" : "A0A7D9NJQ2",
    "standardIdentifier" : "uniprot:A0A7D9NJQ2",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "gsdme" ],
    "parents" : [ 10710228 ],
    "children" : [ ]
  }, {
    "dbId" : 10725103,
    "stId" : "R-XTR-1678924",
    "displayName" : "C-ter TLR7 dimer [endolysosome membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 205621,
    "diagramIds" : [ 133724 ],
    "parents" : [ 10725105 ],
    "children" : [ 10725101 ]
  }, {
    "dbId" : 10660846,
    "stId" : "R-XTR-166010-3",
    "displayName" : "bpi [extracellular region]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 205621,
    "identifier" : "Q5FWR5",
    "standardIdentifier" : "uniprot:Q5FWR5",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "bpi" ],
    "parents" : [ 10660848 ],
    "children" : [ ]
  }, {
    "dbId" : 10729134,
    "stId" : "R-XTR-166058",
    "displayName" : "MyD88:MAL(TIRAP) cascade initiated on plasma membrane",
    "schemaClass" : "Pathway",
    "speciesId" : 205621,
    "diagramIds" : [ 133728 ]
  }, {
    "dbId" : 10725101,
    "stId" : "R-XTR-1679027",
    "displayName" : "tlr7 [endolysosome membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 205621,
    "identifier" : "B2GUH5",
    "standardIdentifier" : "uniprot:B2GUH5",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "tlr7" ],
    "parents" : [ 10725103 ],
    "children" : [ ]
  }, {
    "dbId" : 9824730,
    "stId" : "R-ALL-9824730",
    "displayName" : "Gua-Rib [endolysosome lumen]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "identifier" : "16750",
    "standardIdentifier" : "chebi:16750",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ 9824768 ],
    "children" : [ ]
  }, {
    "dbId" : 10725105,
    "stId" : "R-XTR-9824779",
    "displayName" : "G analog:C-ter TLR7 dimer [endolysosome membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 205621,
    "diagramIds" : [ 133725 ],
    "parents" : [ ],
    "children" : [ 10725103, 9824768 ]
  }, {
    "dbId" : 179856,
    "stId" : "R-ALL-179856",
    "displayName" : "PI(4,5)P2 [plasma membrane]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "identifier" : "58456",
    "standardIdentifier" : "chebi:58456",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ 5620974 ],
    "children" : [ ]
  }, {
    "dbId" : 10660848,
    "stId" : "R-XTR-166010-4",
    "displayName" : "Homologues of LBP [extracellular region]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 205621,
    "diagramIds" : [ 133719 ],
    "parents" : [ 10714468 ],
    "children" : [ 10660846, 10660842, 10660838 ]
  }, {
    "dbId" : 9824768,
    "stId" : "R-ALL-9824768",
    "displayName" : "G analog [endolysosome lumen]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 0,
    "diagramIds" : [ 133723 ],
    "parents" : [ 10725105 ],
    "children" : [ 9824730, 9824783, 9824770, 9824695 ]
  }, {
    "dbId" : 181015,
    "stId" : "R-ALL-181015",
    "displayName" : "Lipoteichoic acid [extracellular region]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 133713 ],
    "identifier" : "28640",
    "standardIdentifier" : "chebi:28640",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ 10709577 ],
    "children" : [ ]
  }, {
    "dbId" : 9824770,
    "stId" : "R-ALL-9824770",
    "displayName" : "dG [endolysosome lumen]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "identifier" : "17172",
    "standardIdentifier" : "chebi:17172",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ 9824768 ],
    "children" : [ ]
  }, {
    "dbId" : 9824783,
    "stId" : "R-ALL-9824783",
    "displayName" : "8-OHdG [endolysosome lumen]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "identifier" : "40304",
    "standardIdentifier" : "chebi:40304",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ 9824768 ],
    "children" : [ ]
  }, {
    "dbId" : 9824695,
    "stId" : "R-ALL-9824695",
    "displayName" : "2',3'-cyclic GMP [endolysosome lumen]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "identifier" : "28181",
    "standardIdentifier" : "chebi:28181",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ 9824768 ],
    "children" : [ ]
  }, {
    "dbId" : 10668032,
    "stId" : "R-XTR-266221",
    "displayName" : "hmgb1 [nucleoplasm]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 205621,
    "diagramIds" : [ 133716 ],
    "identifier" : "Q6P4N5",
    "standardIdentifier" : "uniprot:Q6P4N5",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "hmgb1" ],
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10728896,
    "stId" : "R-XTR-5620971",
    "displayName" : "Pyroptosis",
    "schemaClass" : "Pathway",
    "speciesId" : 205621,
    "diagramIds" : [ 133732 ]
  }, {
    "dbId" : 10709575,
    "stId" : "R-XTR-6797422",
    "displayName" : "hmgb1 [extracellular region]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 205621,
    "diagramIds" : [ 133710 ],
    "identifier" : "Q6P4N5",
    "standardIdentifier" : "uniprot:Q6P4N5",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "hmgb1" ],
    "parents" : [ 10709577, 10709581 ],
    "children" : [ ]
  }, {
    "dbId" : 392417,
    "stId" : "R-ALL-392417",
    "displayName" : "PI4P [plasma membrane]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "identifier" : "17526",
    "standardIdentifier" : "chebi:17526",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ 5620974 ],
    "children" : [ ]
  }, {
    "dbId" : 10709577,
    "stId" : "R-XTR-6801223",
    "displayName" : "HC23,45-HMGB1:LTA [extracellular region]",
    "schemaClass" : "Complex",
    "speciesId" : 205621,
    "diagramIds" : [ 133714 ],
    "parents" : [ ],
    "children" : [ 181015, 10709575 ]
  }, {
    "dbId" : 10709581,
    "stId" : "R-XTR-6801229",
    "displayName" : "HC23,45-HMGB1:LPS [extracellular region]",
    "schemaClass" : "Complex",
    "speciesId" : 205621,
    "diagramIds" : [ 133711 ],
    "parents" : [ ],
    "children" : [ 166005, 10709575 ]
  }, {
    "dbId" : 2186967,
    "stId" : "R-ALL-2186967",
    "displayName" : "oxidized phospholipids [extracellular region]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 133720 ],
    "identifier" : "60156",
    "standardIdentifier" : "chebi:60156",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ 10714468 ],
    "children" : [ ]
  }, {
    "dbId" : 10710228,
    "stId" : "R-XTR-9710248",
    "displayName" : "GSDME oligomer:PIP [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 205621,
    "diagramIds" : [ 133717 ],
    "parents" : [ ],
    "children" : [ 5620974, 10658217 ]
  }, {
    "dbId" : 166005,
    "stId" : "R-ALL-166005",
    "displayName" : "LPS [extracellular region]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 133709 ],
    "identifier" : "16412",
    "standardIdentifier" : "chebi:16412",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ 10709581 ],
    "children" : [ ]
  }, {
    "dbId" : 5620974,
    "stId" : "R-ALL-5620974",
    "displayName" : "PI4P,PI(4,5)P2,PIP3 [plasma membrane]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 0,
    "parents" : [ 10710228 ],
    "children" : [ 179856, 392417, 179838 ]
  }, {
    "dbId" : 179838,
    "stId" : "R-ALL-179838",
    "displayName" : "PI(3,4,5)P3 [plasma membrane]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "identifier" : "57836",
    "standardIdentifier" : "chebi:57836",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ 5620974 ],
    "children" : [ ]
  } ],
  "edges" : [ {
    "dbId" : 10725107,
    "stId" : "R-XTR-9824732",
    "displayName" : "G or G analog binds C-ter TLR7 dimer",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 10725103, 9824768 ],
    "outputs" : [ 10725105 ],
    "efs" : [ ],
    "diagramIds" : [ 133722 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10710230,
    "stId" : "R-XTR-6805981",
    "displayName" : "HMGB1 release from cells",
    "schemaClass" : "BlackBoxEvent",
    "speciesId" : 0,
    "following" : [ 10709579, 10709583 ],
    "inputs" : [ 10668032 ],
    "outputs" : [ 10709575 ],
    "efs" : [ ],
    "activators" : [ 10710228 ],
    "diagramIds" : [ 133715 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10714470,
    "stId" : "R-XTR-8869683",
    "displayName" : "oxPL binds LBP",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 2186967, 10660848 ],
    "outputs" : [ 10714468 ],
    "efs" : [ ],
    "diagramIds" : [ 133718 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10709579,
    "stId" : "R-XTR-6804099",
    "displayName" : "HMGB1 binds LTP",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10710230 ],
    "inputs" : [ 181015, 10709575 ],
    "outputs" : [ 10709577 ],
    "efs" : [ ],
    "diagramIds" : [ 133712 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10709583,
    "stId" : "R-XTR-6804100",
    "displayName" : "HMGB1 binds LPS",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10710230 ],
    "inputs" : [ 166005, 10709575 ],
    "outputs" : [ 10709581 ],
    "efs" : [ ],
    "diagramIds" : [ 133708 ],
    "entityFunctionalStatus" : [ ]
  } ]
}