{
  "dbId" : 10730732,
  "stableId" : "R-XTR-5358508",
  "displayName" : "Mismatch Repair",
  "nodes" : [ {
    "id" : 640,
    "reactomeId" : 10697451,
    "displayName" : "MSH2:MSH3:ADP:DNA containing IDL of 2 bases or more",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 921,
      "y" : 307
    },
    "minX" : 728,
    "maxX" : 1120,
    "minY" : 289,
    "maxY" : 319,
    "prop" : {
      "x" : 728,
      "y" : 295,
      "width" : 386,
      "height" : 24
    },
    "textPosition" : {
      "x" : 743,
      "y" : 298
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1114,
          "y" : 295
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1114,
          "y" : 295
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 637,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 642,
    "reactomeId" : 10697457,
    "displayName" : "msh6",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 385,
      "y" : 110
    },
    "minX" : 355,
    "maxX" : 436,
    "minY" : 93,
    "maxY" : 152,
    "prop" : {
      "x" : 355,
      "y" : 99,
      "width" : 60,
      "height" : 22
    },
    "textPosition" : {
      "x" : 364,
      "y" : 99
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 415,
          "y" : 99
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 415,
          "y" : 99
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 641,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 398,
          "y" : 124
        },
        "to" : {
          "x" : 436,
          "y" : 152
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 643,
    "reactomeId" : 10697443,
    "displayName" : "msh2",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 487,
      "y" : 92
    },
    "minX" : 436,
    "maxX" : 525,
    "minY" : 74,
    "maxY" : 152,
    "prop" : {
      "x" : 456,
      "y" : 80,
      "width" : 63,
      "height" : 25
    },
    "textPosition" : {
      "x" : 466,
      "y" : 82
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 519,
          "y" : 80
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 519,
          "y" : 80
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 641,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 476,
          "y" : 108
        },
        "to" : {
          "x" : 436,
          "y" : 152
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 644,
    "reactomeId" : 113582,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 504,
      "y" : 164
    },
    "minX" : 436,
    "maxX" : 525,
    "minY" : 148,
    "maxY" : 179,
    "prop" : {
      "x" : 485,
      "y" : 149,
      "width" : 39,
      "height" : 30
    },
    "textPosition" : {
      "x" : 488,
      "y" : 153
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 519,
          "y" : 154
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 519,
          "y" : 154
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 641,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 482,
          "y" : 160
        },
        "to" : {
          "x" : 436,
          "y" : 152
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 453,
            "y" : 150
          },
          "b" : {
            "x" : 465,
            "y" : 162
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 459,
            "y" : 156
          }
        }
      }
    } ]
  }, {
    "id" : 646,
    "reactomeId" : 10697447,
    "displayName" : "msh3",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 775,
      "y" : 77
    },
    "minX" : 728,
    "maxX" : 828,
    "minY" : 60,
    "maxY" : 177,
    "prop" : {
      "x" : 728,
      "y" : 66,
      "width" : 94,
      "height" : 23
    },
    "textPosition" : {
      "x" : 754,
      "y" : 67
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 822,
          "y" : 66
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 822,
          "y" : 66
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 645,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 771,
          "y" : 92
        },
        "to" : {
          "x" : 744,
          "y" : 177
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 647,
    "reactomeId" : 113582,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 664,
      "y" : 203
    },
    "minX" : 644,
    "maxX" : 744,
    "minY" : 177,
    "maxY" : 218,
    "prop" : {
      "x" : 644,
      "y" : 188,
      "width" : 40,
      "height" : 30
    },
    "textPosition" : {
      "x" : 647,
      "y" : 192
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 679,
          "y" : 193
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 679,
          "y" : 193
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 645,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 687,
          "y" : 196
        },
        "to" : {
          "x" : 744,
          "y" : 177
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 709,
            "y" : 180
          },
          "b" : {
            "x" : 721,
            "y" : 192
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 715,
            "y" : 186
          }
        }
      }
    } ]
  }, {
    "id" : 648,
    "reactomeId" : 10697443,
    "displayName" : "msh2",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 622,
      "y" : 135
    },
    "minX" : 591,
    "maxX" : 744,
    "minY" : 117,
    "maxY" : 177,
    "prop" : {
      "x" : 591,
      "y" : 123,
      "width" : 63,
      "height" : 25
    },
    "textPosition" : {
      "x" : 601,
      "y" : 125
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 654,
          "y" : 123
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 654,
          "y" : 123
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 645,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 657,
          "y" : 145
        },
        "to" : {
          "x" : 744,
          "y" : 177
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 623,
    "reactomeId" : 10697459,
    "displayName" : "MSH2:MSH6:ADP",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 337,
      "y" : 207
    },
    "minX" : 284,
    "maxX" : 397,
    "minY" : 192,
    "maxY" : 244,
    "prop" : {
      "x" : 284,
      "y" : 198,
      "width" : 107,
      "height" : 19
    },
    "textPosition" : {
      "x" : 294,
      "y" : 182
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 391,
          "y" : 198
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 391,
          "y" : 198
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 641,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 622,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 323,
          "y" : 220
        },
        "to" : {
          "x" : 284,
          "y" : 244
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 624,
    "reactomeId" : 5358514,
    "displayName" : "DNA containing mismatch or 1-2 base IDL",
    "schemaClass" : "OtherEntity",
    "renderableClass" : "Entity",
    "position" : {
      "x" : 178,
      "y" : 143
    },
    "minX" : 116,
    "maxX" : 284,
    "minY" : 109,
    "maxY" : 244,
    "prop" : {
      "x" : 116,
      "y" : 109,
      "width" : 124,
      "height" : 69
    },
    "textPosition" : {
      "x" : 121,
      "y" : 119
    },
    "connectors" : [ {
      "edgeId" : 622,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 214,
          "y" : 181
        },
        "to" : {
          "x" : 284,
          "y" : 244
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 625,
    "reactomeId" : 10697461,
    "displayName" : "MSH2:MSH6:ADP:DNA containing 1-2 base mismatch",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 288,
      "y" : 308
    },
    "minX" : 107,
    "maxX" : 475,
    "minY" : 290,
    "maxY" : 343,
    "prop" : {
      "x" : 107,
      "y" : 296,
      "width" : 362,
      "height" : 24
    },
    "textPosition" : {
      "x" : 121,
      "y" : 299
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 469,
          "y" : 296
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 469,
          "y" : 296
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 626,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 288,
          "y" : 323
        },
        "to" : {
          "x" : 289,
          "y" : 343
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 622,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 627,
    "reactomeId" : 29358,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 367,
      "y" : 342
    },
    "minX" : 289,
    "maxX" : 387,
    "minY" : 326,
    "maxY" : 357,
    "prop" : {
      "x" : 348,
      "y" : 327,
      "width" : 38,
      "height" : 30
    },
    "textPosition" : {
      "x" : 351,
      "y" : 331
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 381,
          "y" : 332
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 381,
          "y" : 332
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 626,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 345,
          "y" : 342
        },
        "to" : {
          "x" : 289,
          "y" : 343
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 311,
            "y" : 336
          },
          "b" : {
            "x" : 323,
            "y" : 348
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 317,
            "y" : 342
          }
        }
      }
    } ]
  }, {
    "id" : 628,
    "reactomeId" : 10697469,
    "displayName" : "MSH2:MSH6:ATP:DNA containing 1-2 base mismatch",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 272,
      "y" : 420
    },
    "minX" : 112,
    "maxX" : 439,
    "minY" : 381,
    "maxY" : 430,
    "prop" : {
      "x" : 112,
      "y" : 410,
      "width" : 321,
      "height" : 20
    },
    "textPosition" : {
      "x" : 136,
      "y" : 395
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 433,
          "y" : 410
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 433,
          "y" : 410
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 626,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 276,
          "y" : 407
        },
        "to" : {
          "x" : 288,
          "y" : 381
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 275,
          "y" : 399
        },
        "b" : {
          "x" : 276,
          "y" : 407
        },
        "c" : {
          "x" : 283,
          "y" : 402
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 283,
          "y" : 402
        }
      }
    } ]
  }, {
    "id" : 629,
    "reactomeId" : 113582,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 195,
      "y" : 388
    },
    "minX" : 176,
    "maxX" : 288,
    "minY" : 372,
    "maxY" : 403,
    "prop" : {
      "x" : 176,
      "y" : 373,
      "width" : 39,
      "height" : 30
    },
    "textPosition" : {
      "x" : 179,
      "y" : 377
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 210,
          "y" : 378
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 210,
          "y" : 378
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 626,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 218,
          "y" : 386
        },
        "to" : {
          "x" : 288,
          "y" : 381
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 247,
            "y" : 377
          },
          "b" : {
            "x" : 259,
            "y" : 389
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 253,
            "y" : 383
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 225,
          "y" : 382
        },
        "b" : {
          "x" : 218,
          "y" : 386
        },
        "c" : {
          "x" : 225,
          "y" : 389
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 225,
          "y" : 389
        }
      }
    } ]
  }, {
    "id" : 631,
    "reactomeId" : 5358610,
    "displayName" : "DNA containing single strand nick (5' phosphate, 3' hydroxyl)",
    "schemaClass" : "OtherEntity",
    "renderableClass" : "Entity",
    "position" : {
      "x" : 711,
      "y" : 956
    },
    "minX" : 503,
    "maxX" : 919,
    "minY" : 941,
    "maxY" : 999,
    "prop" : {
      "x" : 503,
      "y" : 941,
      "width" : 416,
      "height" : 31
    },
    "textPosition" : {
      "x" : 516,
      "y" : 946
    },
    "connectors" : [ {
      "edgeId" : 630,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 664,
          "y" : 975
        },
        "to" : {
          "x" : 583,
          "y" : 999
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 632,
    "reactomeId" : 29358,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 474,
      "y" : 981
    },
    "minX" : 455,
    "maxX" : 583,
    "minY" : 965,
    "maxY" : 999,
    "prop" : {
      "x" : 455,
      "y" : 966,
      "width" : 38,
      "height" : 30
    },
    "textPosition" : {
      "x" : 458,
      "y" : 970
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 488,
          "y" : 971
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 488,
          "y" : 971
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 630,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 496,
          "y" : 984
        },
        "to" : {
          "x" : 583,
          "y" : 999
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 633,
    "reactomeId" : 113541,
    "displayName" : "PPi",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 672,
      "y" : 1111
    },
    "minX" : 554,
    "maxX" : 690,
    "minY" : 1056,
    "maxY" : 1126,
    "prop" : {
      "x" : 656,
      "y" : 1096,
      "width" : 33,
      "height" : 30
    },
    "textPosition" : {
      "x" : 659,
      "y" : 1100
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 684,
          "y" : 1101
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 684,
          "y" : 1101
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 630,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 653,
          "y" : 1103
        },
        "to" : {
          "x" : 554,
          "y" : 1056
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 645,
          "y" : 1104
        },
        "b" : {
          "x" : 653,
          "y" : 1103
        },
        "c" : {
          "x" : 648,
          "y" : 1096
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 648,
          "y" : 1096
        }
      }
    } ]
  }, {
    "id" : 634,
    "reactomeId" : 109966,
    "displayName" : "Repaired double-stranded DNA",
    "schemaClass" : "OtherEntity",
    "renderableClass" : "Entity",
    "position" : {
      "x" : 489,
      "y" : 1113
    },
    "minX" : 358,
    "maxX" : 621,
    "minY" : 1056,
    "maxY" : 1125,
    "prop" : {
      "x" : 358,
      "y" : 1102,
      "width" : 263,
      "height" : 23
    },
    "textPosition" : {
      "x" : 388,
      "y" : 1103
    },
    "connectors" : [ {
      "edgeId" : 630,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 502,
          "y" : 1099
        },
        "to" : {
          "x" : 554,
          "y" : 1056
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 505,
          "y" : 1092
        },
        "b" : {
          "x" : 502,
          "y" : 1099
        },
        "c" : {
          "x" : 510,
          "y" : 1098
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 510,
          "y" : 1098
        }
      }
    } ]
  }, {
    "id" : 635,
    "reactomeId" : 164121,
    "displayName" : "AMP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 467,
      "y" : 1068
    },
    "minX" : 447,
    "maxX" : 554,
    "minY" : 1052,
    "maxY" : 1083,
    "prop" : {
      "x" : 447,
      "y" : 1053,
      "width" : 41,
      "height" : 30
    },
    "textPosition" : {
      "x" : 450,
      "y" : 1057
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 483,
          "y" : 1058
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 483,
          "y" : 1058
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 630,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 491,
          "y" : 1065
        },
        "to" : {
          "x" : 554,
          "y" : 1056
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 497,
          "y" : 1060
        },
        "b" : {
          "x" : 491,
          "y" : 1065
        },
        "c" : {
          "x" : 498,
          "y" : 1068
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 498,
          "y" : 1068
        }
      }
    } ]
  }, {
    "id" : 636,
    "reactomeId" : 10652171,
    "displayName" : "lig1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 480,
      "y" : 1031
    },
    "minX" : 456,
    "maxX" : 559,
    "minY" : 1016,
    "maxY" : 1041,
    "prop" : {
      "x" : 456,
      "y" : 1022,
      "width" : 48,
      "height" : 19
    },
    "textPosition" : {
      "x" : 465,
      "y" : 1021
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 504,
          "y" : 1022
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 504,
          "y" : 1022
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 630,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 507,
          "y" : 1030
        },
        "to" : {
          "x" : 551,
          "y" : 1030
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 555,
          "y" : 1030
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 555,
          "y" : 1030
        }
      }
    } ]
  }, {
    "id" : 638,
    "reactomeId" : 5358527,
    "displayName" : "DNA containing IDL of 2 or more bases",
    "schemaClass" : "OtherEntity",
    "renderableClass" : "Entity",
    "position" : {
      "x" : 1036,
      "y" : 135
    },
    "minX" : 917,
    "maxX" : 1091,
    "minY" : 101,
    "maxY" : 245,
    "prop" : {
      "x" : 982,
      "y" : 101,
      "width" : 109,
      "height" : 68
    },
    "textPosition" : {
      "x" : 981,
      "y" : 110
    },
    "connectors" : [ {
      "edgeId" : 637,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 999,
          "y" : 172
        },
        "to" : {
          "x" : 917,
          "y" : 245
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 639,
    "reactomeId" : 10697449,
    "displayName" : "MSH2:MSH3:ADP",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 845,
      "y" : 213
    },
    "minX" : 792,
    "maxX" : 917,
    "minY" : 196,
    "maxY" : 245,
    "prop" : {
      "x" : 792,
      "y" : 202,
      "width" : 107,
      "height" : 23
    },
    "textPosition" : {
      "x" : 802,
      "y" : 190
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 899,
          "y" : 202
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 899,
          "y" : 202
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 645,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 637,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 870,
          "y" : 228
        },
        "to" : {
          "x" : 917,
          "y" : 245
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  } ],
  "edges" : [ {
    "id" : 641,
    "reactomeId" : 10698105,
    "displayName" : "Formation of MSH2:MSH6 Complex",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 399,
      "y" : 170
    },
    "minX" : 352,
    "maxX" : 436,
    "minY" : 152,
    "maxY" : 195,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 436,
        "y" : 152
      },
      "to" : {
        "x" : 399,
        "y" : 170
      }
    }, {
      "from" : {
        "x" : 399,
        "y" : 170
      },
      "to" : {
        "x" : 352,
        "y" : 195
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 356,
        "y" : 188
      },
      "b" : {
        "x" : 352,
        "y" : 195
      },
      "c" : {
        "x" : 360,
        "y" : 195
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 360,
        "y" : 195
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 399,
        "y" : 170
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 399,
        "y" : 170
      }
    },
    "inputs" : [ {
      "id" : 642,
      "points" : [ {
        "x" : 398,
        "y" : 124
      } ]
    }, {
      "id" : 643,
      "points" : [ {
        "x" : 476,
        "y" : 108
      } ]
    }, {
      "id" : 644,
      "points" : [ {
        "x" : 482,
        "y" : 160
      } ],
      "stoichiometry" : 2
    } ],
    "outputs" : [ {
      "id" : 623
    } ]
  }, {
    "id" : 626,
    "reactomeId" : 10697471,
    "displayName" : "MSH2:MSH6 exchanges ADP for ATP",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 288,
      "y" : 363
    },
    "minX" : 282,
    "maxX" : 294,
    "minY" : 343,
    "maxY" : 381,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 289,
        "y" : 343
      },
      "to" : {
        "x" : 288,
        "y" : 363
      }
    }, {
      "from" : {
        "x" : 288,
        "y" : 363
      },
      "to" : {
        "x" : 288,
        "y" : 381
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 282,
        "y" : 357
      },
      "b" : {
        "x" : 294,
        "y" : 369
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 288,
        "y" : 363
      }
    },
    "inputs" : [ {
      "id" : 625,
      "points" : [ {
        "x" : 288,
        "y" : 323
      } ]
    }, {
      "id" : 627,
      "points" : [ {
        "x" : 345,
        "y" : 342
      } ],
      "stoichiometry" : 2
    } ],
    "outputs" : [ {
      "id" : 628,
      "points" : [ {
        "x" : 276,
        "y" : 407
      } ]
    }, {
      "id" : 629,
      "points" : [ {
        "x" : 218,
        "y" : 386
      } ],
      "stoichiometry" : 2
    } ]
  }, {
    "id" : 645,
    "reactomeId" : 10698103,
    "displayName" : "Formation of MSH2:MSH3 Complex",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 790,
      "y" : 174
    },
    "minX" : 744,
    "maxX" : 828,
    "minY" : 168,
    "maxY" : 199,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 744,
        "y" : 177
      },
      "to" : {
        "x" : 790,
        "y" : 174
      }
    }, {
      "from" : {
        "x" : 790,
        "y" : 174
      },
      "to" : {
        "x" : 828,
        "y" : 199
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 820,
        "y" : 199
      },
      "b" : {
        "x" : 828,
        "y" : 199
      },
      "c" : {
        "x" : 824,
        "y" : 192
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 824,
        "y" : 192
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 790,
        "y" : 174
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 790,
        "y" : 174
      }
    },
    "inputs" : [ {
      "id" : 646,
      "points" : [ {
        "x" : 771,
        "y" : 92
      } ]
    }, {
      "id" : 647,
      "points" : [ {
        "x" : 687,
        "y" : 196
      } ],
      "stoichiometry" : 2
    }, {
      "id" : 648,
      "points" : [ {
        "x" : 657,
        "y" : 145
      } ]
    } ],
    "outputs" : [ {
      "id" : 639
    } ]
  }, {
    "id" : 630,
    "reactomeId" : 10697465,
    "displayName" : "DNA ligase I ligates single stranded nick in double stranded DNA",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 567,
      "y" : 1030
    },
    "minX" : 554,
    "maxX" : 583,
    "minY" : 999,
    "maxY" : 1056,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 583,
        "y" : 999
      },
      "to" : {
        "x" : 567,
        "y" : 1030
      }
    }, {
      "from" : {
        "x" : 567,
        "y" : 1030
      },
      "to" : {
        "x" : 554,
        "y" : 1056
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 561,
        "y" : 1024
      },
      "b" : {
        "x" : 573,
        "y" : 1036
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 567,
        "y" : 1030
      }
    },
    "inputs" : [ {
      "id" : 631,
      "points" : [ {
        "x" : 664,
        "y" : 975
      } ]
    }, {
      "id" : 632,
      "points" : [ {
        "x" : 496,
        "y" : 984
      } ]
    } ],
    "outputs" : [ {
      "id" : 633,
      "points" : [ {
        "x" : 653,
        "y" : 1103
      } ]
    }, {
      "id" : 634,
      "points" : [ {
        "x" : 502,
        "y" : 1099
      } ]
    }, {
      "id" : 635,
      "points" : [ {
        "x" : 491,
        "y" : 1065
      } ]
    } ],
    "catalysts" : [ {
      "id" : 636,
      "points" : [ {
        "x" : 507,
        "y" : 1030
      } ]
    } ]
  }, {
    "id" : 637,
    "reactomeId" : 10697453,
    "displayName" : "MSH2:MSH3 binds insertion/deletion loop of 2 bases or more",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 919,
      "y" : 270
    },
    "minX" : 913,
    "maxX" : 925,
    "minY" : 245,
    "maxY" : 292,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 917,
        "y" : 245
      },
      "to" : {
        "x" : 919,
        "y" : 270
      }
    }, {
      "from" : {
        "x" : 919,
        "y" : 270
      },
      "to" : {
        "x" : 920,
        "y" : 292
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 916,
        "y" : 285
      },
      "b" : {
        "x" : 920,
        "y" : 292
      },
      "c" : {
        "x" : 924,
        "y" : 285
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 924,
        "y" : 285
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 919,
        "y" : 270
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 919,
        "y" : 270
      }
    },
    "inputs" : [ {
      "id" : 638,
      "points" : [ {
        "x" : 999,
        "y" : 172
      } ]
    }, {
      "id" : 639,
      "points" : [ {
        "x" : 870,
        "y" : 228
      } ]
    } ],
    "outputs" : [ {
      "id" : 640
    } ]
  }, {
    "id" : 622,
    "reactomeId" : 10697463,
    "displayName" : "MSH2:MSH6 binds 1 base mismatch or 1-2 base insertion/deletion loop",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 286,
      "y" : 266
    },
    "minX" : 280,
    "maxX" : 292,
    "minY" : 244,
    "maxY" : 293,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 284,
        "y" : 244
      },
      "to" : {
        "x" : 286,
        "y" : 266
      }
    }, {
      "from" : {
        "x" : 286,
        "y" : 266
      },
      "to" : {
        "x" : 287,
        "y" : 293
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 283,
        "y" : 286
      },
      "b" : {
        "x" : 287,
        "y" : 293
      },
      "c" : {
        "x" : 291,
        "y" : 286
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 291,
        "y" : 286
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 286,
        "y" : 266
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 286,
        "y" : 266
      }
    },
    "inputs" : [ {
      "id" : 623,
      "points" : [ {
        "x" : 323,
        "y" : 220
      } ]
    }, {
      "id" : 624,
      "points" : [ {
        "x" : 214,
        "y" : 181
      } ]
    } ],
    "outputs" : [ {
      "id" : 625
    } ]
  } ],
  "compartments" : [ {
    "id" : 660,
    "reactomeId" : 459,
    "displayName" : "cytoplasm",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 585,
      "y" : 608
    },
    "minX" : 0,
    "maxX" : 1171,
    "minY" : 0,
    "maxY" : 1216,
    "prop" : {
      "x" : 0,
      "y" : 0,
      "width" : 1171,
      "height" : 1216
    },
    "textPosition" : {
      "x" : 1053,
      "y" : 1171
    },
    "insets" : {
      "x" : 10,
      "y" : 10,
      "width" : 1151,
      "height" : 1196
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 649 ]
  }, {
    "id" : 649,
    "reactomeId" : 7660,
    "displayName" : "nucleoplasm",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 601,
      "y" : 590
    },
    "minX" : 55,
    "maxX" : 1148,
    "minY" : 28,
    "maxY" : 1152,
    "prop" : {
      "x" : 55,
      "y" : 28,
      "width" : 1093,
      "height" : 1124
    },
    "textPosition" : {
      "x" : 71,
      "y" : 1099
    },
    "insets" : {
      "x" : 65,
      "y" : 38,
      "width" : 1073,
      "height" : 1104
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 622, 623, 624, 625, 626, 627, 628, 629, 631, 630, 632, 633, 634, 635, 636, 637, 638, 639, 640, 641, 642, 643, 644, 645, 646, 647, 648 ]
  } ],
  "notes" : [ ],
  "links" : [ ],
  "shadows" : [ {
    "id" : 661,
    "reactomeId" : 10730730,
    "displayName" : "Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)",
    "schemaClass" : "Pathway",
    "renderableClass" : "Shadow",
    "position" : {
      "x" : 736,
      "y" : 596
    },
    "minX" : 348,
    "maxX" : 1124,
    "minY" : 56,
    "maxY" : 1136,
    "prop" : {
      "x" : 929,
      "y" : 70,
      "width" : 195,
      "height" : 1066
    },
    "points" : [ {
      "x" : 348,
      "y" : 56
    }, {
      "x" : 1124,
      "y" : 56
    }, {
      "x" : 1124,
      "y" : 1136
    }, {
      "x" : 348,
      "y" : 1136
    } ],
    "colour" : "#4684ee"
  }, {
    "id" : 662,
    "reactomeId" : 10730734,
    "displayName" : "Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)",
    "schemaClass" : "Pathway",
    "renderableClass" : "Shadow",
    "position" : {
      "x" : 513,
      "y" : 603
    },
    "minX" : 97,
    "maxX" : 929,
    "minY" : 70,
    "maxY" : 1136,
    "prop" : {
      "x" : 97,
      "y" : 70,
      "width" : 251,
      "height" : 1066
    },
    "points" : [ {
      "x" : 97,
      "y" : 70
    }, {
      "x" : 929,
      "y" : 70
    }, {
      "x" : 929,
      "y" : 1136
    }, {
      "x" : 97,
      "y" : 1136
    } ],
    "colour" : "#dc3912"
  } ],
  "minX" : 0,
  "maxX" : 1171,
  "minY" : 0,
  "maxY" : 1216,
  "disease" : false
}