{
  "dbId" : 10729766,
  "stableId" : "R-XTR-380972",
  "displayName" : "Energy dependent regulation of mTOR by LKB1-AMPK",
  "nodes" : [ {
    "id" : 14512,
    "reactomeId" : 10670969,
    "displayName" : "mTORC1:Ragulator:Rag:GNP:RHEB:GDP",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 570,
      "y" : 995
    },
    "minX" : 507,
    "maxX" : 639,
    "minY" : 932,
    "maxY" : 1013,
    "prop" : {
      "x" : 507,
      "y" : 977,
      "width" : 126,
      "height" : 36
    },
    "textPosition" : {
      "x" : 519,
      "y" : 964
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 633,
          "y" : 977
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 633,
          "y" : 977
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 14510,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 588,
          "y" : 974
        },
        "to" : {
          "x" : 633,
          "y" : 932
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 590,
          "y" : 966
        },
        "b" : {
          "x" : 588,
          "y" : 974
        },
        "c" : {
          "x" : 596,
          "y" : 972
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 596,
          "y" : 972
        }
      }
    } ]
  }, {
    "id" : 14529,
    "reactomeId" : 10660800,
    "displayName" : "mTORC1 with p-S722,S792-RPTOR:Ragulator:Rag:GNP:RHEB:GTP",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 305,
      "y" : 928
    },
    "minX" : 244,
    "maxX" : 373,
    "minY" : 890,
    "maxY" : 960,
    "prop" : {
      "x" : 244,
      "y" : 896,
      "width" : 123,
      "height" : 64
    },
    "textPosition" : {
      "x" : 247,
      "y" : 883
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 367,
          "y" : 896
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 367,
          "y" : 896
        }
      }
    },
    "connectors" : [ ]
  }, {
    "id" : 14513,
    "reactomeId" : 29372,
    "displayName" : "Pi",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 694,
      "y" : 973
    },
    "minX" : 633,
    "maxX" : 709,
    "minY" : 932,
    "maxY" : 986,
    "prop" : {
      "x" : 681,
      "y" : 960,
      "width" : 27,
      "height" : 26
    },
    "textPosition" : {
      "x" : 685,
      "y" : 962
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 703,
          "y" : 965
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 703,
          "y" : 965
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 14510,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 678,
          "y" : 963
        },
        "to" : {
          "x" : 633,
          "y" : 932
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 670,
          "y" : 962
        },
        "b" : {
          "x" : 678,
          "y" : 963
        },
        "c" : {
          "x" : 675,
          "y" : 956
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 675,
          "y" : 956
        }
      }
    } ]
  }, {
    "id" : 14514,
    "reactomeId" : 10670967,
    "displayName" : "TSC1:p-S1387-TSC2",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1091,
      "y" : 629
    },
    "minX" : 650,
    "maxX" : 1155,
    "minY" : 604,
    "maxY" : 875,
    "prop" : {
      "x" : 1033,
      "y" : 610,
      "width" : 116,
      "height" : 38
    },
    "textPosition" : {
      "x" : 1041,
      "y" : 613
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1149,
          "y" : 610
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1149,
          "y" : 610
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 14510,
      "type" : "ACTIVATOR",
      "segments" : [ {
        "from" : {
          "x" : 1056,
          "y" : 651
        },
        "to" : {
          "x" : 650,
          "y" : 875
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 654,
          "y" : 868
        },
        "b" : {
          "x" : 650,
          "y" : 875
        },
        "c" : {
          "x" : 658,
          "y" : 875
        },
        "type" : "ARROW",
        "empty" : true,
        "centre" : {
          "x" : 658,
          "y" : 875
        }
      }
    } ]
  }, {
    "id" : 14531,
    "reactomeId" : 10729094,
    "displayName" : "MTOR signalling",
    "schemaClass" : "Pathway",
    "renderableClass" : "EncapsulatedNode",
    "position" : {
      "x" : 119,
      "y" : 985
    },
    "minX" : 39,
    "maxX" : 200,
    "minY" : 961,
    "maxY" : 1010,
    "prop" : {
      "x" : 39,
      "y" : 961,
      "width" : 161,
      "height" : 49
    },
    "textPosition" : {
      "x" : 63,
      "y" : 971
    },
    "connectors" : [ ]
  }, {
    "id" : 14511,
    "reactomeId" : 10660771,
    "displayName" : "Active mTORC1 complex",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 464,
      "y" : 926
    },
    "minX" : 412,
    "maxX" : 634,
    "minY" : 875,
    "maxY" : 944,
    "prop" : {
      "x" : 412,
      "y" : 908,
      "width" : 105,
      "height" : 36
    },
    "textPosition" : {
      "x" : 412,
      "y" : 909
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 517,
          "y" : 908
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 517,
          "y" : 908
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 14510,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 14510,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 496,
          "y" : 905
        },
        "to" : {
          "x" : 551,
          "y" : 878
        }
      }, {
        "from" : {
          "x" : 551,
          "y" : 878
        },
        "to" : {
          "x" : 626,
          "y" : 879
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 630,
          "y" : 879
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 630,
          "y" : 879
        }
      }
    } ]
  } ],
  "edges" : [ {
    "id" : 14510,
    "reactomeId" : 10670972,
    "displayName" : "RHEB in mTORC1:RHEB:GTP hydrolyses GTP",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 642,
      "y" : 879
    },
    "minX" : 520,
    "maxX" : 648,
    "minY" : 873,
    "maxY" : 932,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 520,
        "y" : 912
      },
      "to" : {
        "x" : 642,
        "y" : 879
      }
    }, {
      "from" : {
        "x" : 642,
        "y" : 879
      },
      "to" : {
        "x" : 633,
        "y" : 932
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 636,
        "y" : 873
      },
      "b" : {
        "x" : 648,
        "y" : 885
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 642,
        "y" : 879
      }
    },
    "inputs" : [ {
      "id" : 14511
    } ],
    "outputs" : [ {
      "id" : 14512,
      "points" : [ {
        "x" : 588,
        "y" : 974
      } ]
    }, {
      "id" : 14513,
      "points" : [ {
        "x" : 678,
        "y" : 963
      } ]
    } ],
    "catalysts" : [ {
      "id" : 14511,
      "points" : [ {
        "x" : 496,
        "y" : 905
      }, {
        "x" : 551,
        "y" : 878
      } ]
    } ],
    "activators" : [ {
      "id" : 14514,
      "points" : [ {
        "x" : 1056,
        "y" : 651
      } ]
    } ]
  } ],
  "compartments" : [ {
    "id" : 14530,
    "reactomeId" : 17938,
    "displayName" : "lysosomal membrane",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 407,
      "y" : 979
    },
    "minX" : 264,
    "maxX" : 550,
    "minY" : 911,
    "maxY" : 1047,
    "prop" : {
      "x" : 264,
      "y" : 911,
      "width" : 286,
      "height" : 136
    },
    "textPosition" : {
      "x" : 333,
      "y" : 1010
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 14529, 14511, 14512, 14533 ]
  }, {
    "id" : 14523,
    "reactomeId" : 70101,
    "displayName" : "cytosol",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 560,
      "y" : 543
    },
    "minX" : 0,
    "maxX" : 1120,
    "minY" : 0,
    "maxY" : 1087,
    "prop" : {
      "x" : 0,
      "y" : 0,
      "width" : 1120,
      "height" : 1087
    },
    "textPosition" : {
      "x" : 71,
      "y" : 1016
    },
    "insets" : {
      "x" : 10,
      "y" : 10,
      "width" : 1100,
      "height" : 1067
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 14526, 14514, 14510, 14513, 14530, 14531, 14532 ]
  } ],
  "notes" : [ {
    "id" : 14526,
    "displayName" : "High ATP concentration",
    "renderableClass" : "Note",
    "position" : {
      "x" : 120,
      "y" : 514
    },
    "minX" : 26,
    "maxX" : 215,
    "minY" : 437,
    "maxY" : 591,
    "prop" : {
      "x" : 26,
      "y" : 437,
      "width" : 189,
      "height" : 154
    },
    "textPosition" : {
      "x" : 43,
      "y" : 503
    }
  } ],
  "links" : [ {
    "id" : 14532,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 216,
      "y" : 951
    },
    "minX" : 191,
    "maxX" : 241,
    "minY" : 944,
    "maxY" : 958,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 241,
        "y" : 944
      },
      "to" : {
        "x" : 191,
        "y" : 958
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 197,
        "y" : 952
      },
      "b" : {
        "x" : 191,
        "y" : 958
      },
      "c" : {
        "x" : 199,
        "y" : 960
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 199,
        "y" : 960
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 210,
        "y" : 945
      },
      "b" : {
        "x" : 222,
        "y" : 957
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 216,
        "y" : 951
      }
    },
    "inputs" : [ {
      "id" : 14529
    } ],
    "outputs" : [ {
      "id" : 14531
    } ]
  }, {
    "id" : 14533,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 379,
      "y" : 985
    },
    "minX" : 203,
    "maxX" : 438,
    "minY" : 947,
    "maxY" : 991,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 438,
        "y" : 947
      },
      "to" : {
        "x" : 379,
        "y" : 985
      }
    }, {
      "from" : {
        "x" : 379,
        "y" : 985
      },
      "to" : {
        "x" : 203,
        "y" : 985
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 210,
        "y" : 981
      },
      "b" : {
        "x" : 203,
        "y" : 985
      },
      "c" : {
        "x" : 210,
        "y" : 989
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 210,
        "y" : 989
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 373,
        "y" : 979
      },
      "b" : {
        "x" : 385,
        "y" : 991
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 379,
        "y" : 985
      }
    },
    "inputs" : [ {
      "id" : 14511
    } ],
    "outputs" : [ {
      "id" : 14531
    } ]
  } ],
  "shadows" : [ ],
  "minX" : 0,
  "maxX" : 1155,
  "minY" : 0,
  "maxY" : 1087,
  "disease" : false
}