{
  "dbId" : 10728728,
  "stableId" : "R-XTR-2162123",
  "displayName" : "Synthesis of Prostaglandins (PG) and Thromboxanes (TX)",
  "nodes" : [ {
    "id" : 22976,
    "reactomeId" : 879535,
    "displayName" : "PGF2a",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 95,
      "y" : 262
    },
    "minX" : 65,
    "maxX" : 126,
    "minY" : 246,
    "maxY" : 540,
    "prop" : {
      "x" : 65,
      "y" : 247,
      "width" : 60,
      "height" : 31
    },
    "textPosition" : {
      "x" : 71,
      "y" : 252
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 120,
          "y" : 252
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 120,
          "y" : 252
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 22972,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 94,
          "y" : 281
        },
        "to" : {
          "x" : 94,
          "y" : 540
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 98,
          "y" : 288
        },
        "b" : {
          "x" : 94,
          "y" : 281
        },
        "c" : {
          "x" : 90,
          "y" : 288
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 90,
          "y" : 288
        }
      }
    } ]
  }, {
    "id" : 22977,
    "reactomeId" : 29366,
    "displayName" : "NADP+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 78,
      "y" : 583
    },
    "minX" : 47,
    "maxX" : 111,
    "minY" : 540,
    "maxY" : 598,
    "prop" : {
      "x" : 47,
      "y" : 568,
      "width" : 63,
      "height" : 30
    },
    "textPosition" : {
      "x" : 52,
      "y" : 572
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 105,
          "y" : 573
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 105,
          "y" : 573
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 22972,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 83,
          "y" : 565
        },
        "to" : {
          "x" : 94,
          "y" : 540
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 82,
          "y" : 557
        },
        "b" : {
          "x" : 83,
          "y" : 565
        },
        "c" : {
          "x" : 89,
          "y" : 560
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 89,
          "y" : 560
        }
      }
    } ]
  }, {
    "id" : 22978,
    "reactomeId" : 10689023,
    "displayName" : "cbr1.2",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 171,
      "y" : 599
    },
    "minX" : 148,
    "maxX" : 200,
    "minY" : 548,
    "maxY" : 610,
    "prop" : {
      "x" : 148,
      "y" : 588,
      "width" : 46,
      "height" : 22
    },
    "textPosition" : {
      "x" : 151,
      "y" : 582
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 194,
          "y" : 588
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 194,
          "y" : 588
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 22972,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 171,
          "y" : 585
        },
        "to" : {
          "x" : 171,
          "y" : 556
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 171,
          "y" : 552
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 171,
          "y" : 552
        }
      }
    } ]
  }, {
    "id" : 22980,
    "reactomeId" : 2161634,
    "displayName" : "PGD2",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 953,
      "y" : 1094
    },
    "minX" : 926,
    "maxX" : 981,
    "minY" : 1078,
    "maxY" : 1109,
    "prop" : {
      "x" : 926,
      "y" : 1079,
      "width" : 54,
      "height" : 30
    },
    "textPosition" : {
      "x" : 932,
      "y" : 1083
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 975,
          "y" : 1084
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 975,
          "y" : 1084
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 22979,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 22981,
    "reactomeId" : 10689016,
    "displayName" : "ptgds",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 872,
      "y" : 891
    },
    "minX" : 845,
    "maxX" : 955,
    "minY" : 874,
    "maxY" : 902,
    "prop" : {
      "x" : 845,
      "y" : 880,
      "width" : 55,
      "height" : 22
    },
    "textPosition" : {
      "x" : 850,
      "y" : 880
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 900,
          "y" : 880
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 900,
          "y" : 880
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 22979,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 903,
          "y" : 891
        },
        "to" : {
          "x" : 947,
          "y" : 892
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 951,
          "y" : 892
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 951,
          "y" : 892
        }
      }
    } ]
  }, {
    "id" : 22983,
    "reactomeId" : 879629,
    "displayName" : "PGD2",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 437,
      "y" : 521
    },
    "minX" : 410,
    "maxX" : 465,
    "minY" : 505,
    "maxY" : 536,
    "prop" : {
      "x" : 410,
      "y" : 506,
      "width" : 54,
      "height" : 30
    },
    "textPosition" : {
      "x" : 416,
      "y" : 510
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 459,
          "y" : 511
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 459,
          "y" : 511
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 22982,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 22984,
    "reactomeId" : 10689037,
    "displayName" : "HPGDS dimer",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 503,
      "y" : 465
    },
    "minX" : 445,
    "maxX" : 537,
    "minY" : 442,
    "maxY" : 482,
    "prop" : {
      "x" : 476,
      "y" : 448,
      "width" : 55,
      "height" : 34
    },
    "textPosition" : {
      "x" : 476,
      "y" : 447
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 531,
          "y" : 448
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 531,
          "y" : 448
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 22982,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 473,
          "y" : 465
        },
        "to" : {
          "x" : 453,
          "y" : 465
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 449,
          "y" : 465
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 449,
          "y" : 465
        }
      }
    } ]
  }, {
    "id" : 22986,
    "reactomeId" : 31593,
    "displayName" : "PGI2",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1059,
      "y" : 927
    },
    "minX" : 1035,
    "maxX" : 1085,
    "minY" : 911,
    "maxY" : 942,
    "prop" : {
      "x" : 1035,
      "y" : 912,
      "width" : 49,
      "height" : 30
    },
    "textPosition" : {
      "x" : 1041,
      "y" : 916
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1079,
          "y" : 917
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1079,
          "y" : 917
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 22985,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 22987,
    "reactomeId" : 10656381,
    "displayName" : "PTGIS,CYP8B1",
    "schemaClass" : "CandidateSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1587,
      "y" : 857
    },
    "minX" : 1067,
    "maxX" : 1643,
    "minY" : 846,
    "maxY" : 868,
    "prop" : {
      "x" : 1531,
      "y" : 846,
      "width" : 112,
      "height" : 22
    },
    "textPosition" : {
      "x" : 1540,
      "y" : 846
    },
    "connectors" : [ {
      "edgeId" : 22985,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 1525,
          "y" : 857
        },
        "to" : {
          "x" : 1075,
          "y" : 858
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1071,
          "y" : 858
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1071,
          "y" : 858
        }
      }
    } ]
  }, {
    "id" : 23052,
    "reactomeId" : 10731370,
    "displayName" : "Aspirin ADME",
    "schemaClass" : "Pathway",
    "renderableClass" : "EncapsulatedNode",
    "position" : {
      "x" : 1099,
      "y" : 20
    },
    "minX" : 1040,
    "maxX" : 1158,
    "minY" : 0,
    "maxY" : 41,
    "prop" : {
      "x" : 1040,
      "y" : 0,
      "width" : 118,
      "height" : 41
    },
    "textPosition" : {
      "x" : 1050,
      "y" : 6
    },
    "connectors" : [ ]
  }, {
    "id" : 22989,
    "reactomeId" : 10667892,
    "displayName" : "PTGES2(88-377), PTGES3",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 237,
      "y" : 459
    },
    "minX" : 181,
    "maxX" : 328,
    "minY" : 441,
    "maxY" : 477,
    "prop" : {
      "x" : 181,
      "y" : 441,
      "width" : 112,
      "height" : 36
    },
    "textPosition" : {
      "x" : 190,
      "y" : 441
    },
    "connectors" : [ {
      "edgeId" : 22988,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 299,
          "y" : 466
        },
        "to" : {
          "x" : 320,
          "y" : 470
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 324,
          "y" : 471
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 324,
          "y" : 471
        }
      }
    } ]
  }, {
    "id" : 22991,
    "reactomeId" : 10690057,
    "displayName" : "PTGS2 dimer",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1609,
      "y" : 395
    },
    "minX" : 1103,
    "maxX" : 1666,
    "minY" : 184,
    "maxY" : 523,
    "prop" : {
      "x" : 1558,
      "y" : 384,
      "width" : 102,
      "height" : 22
    },
    "textPosition" : {
      "x" : 1565,
      "y" : 385
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1660,
          "y" : 384
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1660,
          "y" : 384
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 23010,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1621,
          "y" : 381
        },
        "to" : {
          "x" : 1656,
          "y" : 353
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 22990,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 1555,
          "y" : 394
        },
        "to" : {
          "x" : 1403,
          "y" : 394
        }
      }, {
        "from" : {
          "x" : 1403,
          "y" : 394
        },
        "to" : {
          "x" : 1291,
          "y" : 395
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1287,
          "y" : 395
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1287,
          "y" : 395
        }
      }
    }, {
      "edgeId" : 22992,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 1555,
          "y" : 401
        },
        "to" : {
          "x" : 1295,
          "y" : 434
        }
      }, {
        "from" : {
          "x" : 1295,
          "y" : 434
        },
        "to" : {
          "x" : 1111,
          "y" : 517
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1107,
          "y" : 519
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1107,
          "y" : 519
        }
      }
    }, {
      "edgeId" : 22999,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1583,
          "y" : 381
        },
        "to" : {
          "x" : 1232,
          "y" : 230
        }
      }, {
        "from" : {
          "x" : 1232,
          "y" : 230
        },
        "to" : {
          "x" : 1232,
          "y" : 184
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 23004,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1608,
          "y" : 409
        },
        "to" : {
          "x" : 1606,
          "y" : 440
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 23006,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1594,
          "y" : 381
        },
        "to" : {
          "x" : 1488,
          "y" : 303
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 22993,
    "reactomeId" : 549282,
    "displayName" : "MNA",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 883,
      "y" : 583
    },
    "minX" : 859,
    "maxX" : 1087,
    "minY" : 524,
    "maxY" : 598,
    "prop" : {
      "x" : 859,
      "y" : 568,
      "width" : 49,
      "height" : 30
    },
    "textPosition" : {
      "x" : 866,
      "y" : 572
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 903,
          "y" : 573
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 903,
          "y" : 573
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 22992,
      "type" : "ACTIVATOR",
      "segments" : [ {
        "from" : {
          "x" : 911,
          "y" : 576
        },
        "to" : {
          "x" : 1087,
          "y" : 526
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1081,
          "y" : 532
        },
        "b" : {
          "x" : 1087,
          "y" : 526
        },
        "c" : {
          "x" : 1079,
          "y" : 524
        },
        "type" : "ARROW",
        "empty" : true,
        "centre" : {
          "x" : 1079,
          "y" : 524
        }
      }
    } ]
  }, {
    "id" : 22994,
    "reactomeId" : 10690060,
    "displayName" : "PTGS2 dimer:PTGS2 inhibitors",
    "schemaClass" : "Complex",
    "renderableClass" : "ComplexDrug",
    "position" : {
      "x" : 1610,
      "y" : 521
    },
    "minX" : 1104,
    "maxX" : 1679,
    "minY" : 459,
    "maxY" : 539,
    "prop" : {
      "x" : 1547,
      "y" : 503,
      "width" : 126,
      "height" : 36
    },
    "textPosition" : {
      "x" : 1555,
      "y" : 504
    },
    "bgColor" : {
      "r" : 184,
      "g" : 154,
      "b" : 230
    },
    "fgColor" : {
      "r" : 161,
      "g" : 1,
      "b" : 2
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1673,
          "y" : 503
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1673,
          "y" : 503
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 22992,
      "type" : "INHIBITOR",
      "segments" : [ {
        "from" : {
          "x" : 1568,
          "y" : 500
        },
        "to" : {
          "x" : 1467,
          "y" : 459
        }
      }, {
        "from" : {
          "x" : 1467,
          "y" : 459
        },
        "to" : {
          "x" : 1105,
          "y" : 522
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1104,
          "y" : 518
        },
        "b" : {
          "x" : 1106,
          "y" : 526
        },
        "c" : {
          "x" : 1105,
          "y" : 522
        },
        "type" : "STOP",
        "centre" : {
          "x" : 1105,
          "y" : 522
        }
      }
    }, {
      "edgeId" : 23004,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 22996,
    "reactomeId" : 2314693,
    "displayName" : "ASA-",
    "schemaClass" : "ChemicalDrug",
    "renderableClass" : "ChemicalDrug",
    "position" : {
      "x" : 1147,
      "y" : 171
    },
    "minX" : 1069,
    "maxX" : 1232,
    "minY" : 154,
    "maxY" : 189,
    "prop" : {
      "x" : 1123,
      "y" : 154,
      "width" : 49,
      "height" : 35
    },
    "textPosition" : {
      "x" : 1129,
      "y" : 161
    },
    "bgColor" : {
      "r" : 184,
      "g" : 154,
      "b" : 230
    },
    "connectors" : [ {
      "edgeId" : 22995,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1120,
          "y" : 176
        },
        "to" : {
          "x" : 1069,
          "y" : 188
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 22999,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1175,
          "y" : 174
        },
        "to" : {
          "x" : 1232,
          "y" : 184
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 22997,
    "reactomeId" : 10690073,
    "displayName" : "Ac-PTGS1 dimer",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 935,
      "y" : 199
    },
    "minX" : 902,
    "maxX" : 1069,
    "minY" : 132,
    "maxY" : 217,
    "prop" : {
      "x" : 902,
      "y" : 181,
      "width" : 67,
      "height" : 36
    },
    "textPosition" : {
      "x" : 900,
      "y" : 182
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 969,
          "y" : 181
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 969,
          "y" : 181
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 22995,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 972,
          "y" : 182
        },
        "to" : {
          "x" : 1069,
          "y" : 132
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 976,
          "y" : 175
        },
        "b" : {
          "x" : 972,
          "y" : 182
        },
        "c" : {
          "x" : 980,
          "y" : 182
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 980,
          "y" : 182
        }
      }
    } ]
  }, {
    "id" : 22998,
    "reactomeId" : 2314690,
    "displayName" : "ST",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1154,
      "y" : 117
    },
    "minX" : 1069,
    "maxX" : 1233,
    "minY" : 101,
    "maxY" : 132,
    "prop" : {
      "x" : 1139,
      "y" : 102,
      "width" : 30,
      "height" : 30
    },
    "textPosition" : {
      "x" : 1142,
      "y" : 106
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1164,
          "y" : 107
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1164,
          "y" : 107
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 22995,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1136,
          "y" : 119
        },
        "to" : {
          "x" : 1069,
          "y" : 132
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1130,
          "y" : 124
        },
        "b" : {
          "x" : 1136,
          "y" : 119
        },
        "c" : {
          "x" : 1128,
          "y" : 116
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1128,
          "y" : 116
        }
      }
    }, {
      "edgeId" : 22999,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1172,
          "y" : 119
        },
        "to" : {
          "x" : 1233,
          "y" : 129
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1179,
          "y" : 116
        },
        "b" : {
          "x" : 1172,
          "y" : 119
        },
        "c" : {
          "x" : 1178,
          "y" : 124
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1178,
          "y" : 124
        }
      }
    } ]
  }, {
    "id" : 23000,
    "reactomeId" : 10689109,
    "displayName" : "Ac-PTGS2 dimer",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1303,
      "y" : 203
    },
    "minX" : 1233,
    "maxX" : 1343,
    "minY" : 129,
    "maxY" : 220,
    "prop" : {
      "x" : 1270,
      "y" : 186,
      "width" : 67,
      "height" : 34
    },
    "textPosition" : {
      "x" : 1268,
      "y" : 185
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1337,
          "y" : 186
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1337,
          "y" : 186
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 22999,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1286,
          "y" : 183
        },
        "to" : {
          "x" : 1233,
          "y" : 129
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1278,
          "y" : 181
        },
        "b" : {
          "x" : 1286,
          "y" : 183
        },
        "c" : {
          "x" : 1284,
          "y" : 175
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1284,
          "y" : 175
        }
      }
    } ]
  }, {
    "id" : 23002,
    "reactomeId" : 9677343,
    "displayName" : "PTGS1 Inhibitors",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySetDrug",
    "position" : {
      "x" : 740,
      "y" : 422
    },
    "minX" : 672,
    "maxX" : 848,
    "minY" : 410,
    "maxY" : 435,
    "prop" : {
      "x" : 672,
      "y" : 410,
      "width" : 137,
      "height" : 25
    },
    "textPosition" : {
      "x" : 685,
      "y" : 412
    },
    "bgColor" : {
      "r" : 184,
      "g" : 154,
      "b" : 230
    },
    "fgColor" : {
      "r" : 161,
      "g" : 1,
      "b" : 2
    },
    "connectors" : [ {
      "edgeId" : 23001,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 815,
          "y" : 423
        },
        "to" : {
          "x" : 848,
          "y" : 424
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 23003,
    "reactomeId" : 10722377,
    "displayName" : "PTGS1 dimer:PTGS1 Inhibitors",
    "schemaClass" : "Complex",
    "renderableClass" : "ComplexDrug",
    "position" : {
      "x" : 871,
      "y" : 508
    },
    "minX" : 808,
    "maxX" : 940,
    "minY" : 486,
    "maxY" : 525,
    "prop" : {
      "x" : 808,
      "y" : 492,
      "width" : 126,
      "height" : 33
    },
    "textPosition" : {
      "x" : 816,
      "y" : 490
    },
    "bgColor" : {
      "r" : 184,
      "g" : 154,
      "b" : 230
    },
    "fgColor" : {
      "r" : 161,
      "g" : 1,
      "b" : 2
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 934,
          "y" : 492
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 934,
          "y" : 492
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 23001,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 23005,
    "reactomeId" : 9716714,
    "displayName" : "PTGS2 inhibitors",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySetDrug",
    "position" : {
      "x" : 1673,
      "y" : 432
    },
    "minX" : 1606,
    "maxX" : 1716,
    "minY" : 415,
    "maxY" : 449,
    "prop" : {
      "x" : 1630,
      "y" : 415,
      "width" : 86,
      "height" : 34
    },
    "textPosition" : {
      "x" : 1640,
      "y" : 415
    },
    "bgColor" : {
      "r" : 184,
      "g" : 154,
      "b" : 230
    },
    "fgColor" : {
      "r" : 161,
      "g" : 1,
      "b" : 2
    },
    "connectors" : [ {
      "edgeId" : 23004,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1624,
          "y" : 437
        },
        "to" : {
          "x" : 1606,
          "y" : 440
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 23007,
    "reactomeId" : 9716837,
    "displayName" : "PTGS inhibitors",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySetDrug",
    "position" : {
      "x" : 1320,
      "y" : 115
    },
    "minX" : 1257,
    "maxX" : 1675,
    "minY" : 103,
    "maxY" : 353,
    "prop" : {
      "x" : 1257,
      "y" : 103,
      "width" : 127,
      "height" : 25
    },
    "textPosition" : {
      "x" : 1269,
      "y" : 105
    },
    "bgColor" : {
      "r" : 184,
      "g" : 154,
      "b" : 230
    },
    "fgColor" : {
      "r" : 161,
      "g" : 1,
      "b" : 2
    },
    "connectors" : [ {
      "edgeId" : 23010,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1390,
          "y" : 114
        },
        "to" : {
          "x" : 1673,
          "y" : 114
        }
      }, {
        "from" : {
          "x" : 1673,
          "y" : 114
        },
        "to" : {
          "x" : 1675,
          "y" : 324
        }
      }, {
        "from" : {
          "x" : 1675,
          "y" : 324
        },
        "to" : {
          "x" : 1656,
          "y" : 353
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 23006,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1331,
          "y" : 134
        },
        "to" : {
          "x" : 1488,
          "y" : 303
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 23008,
    "reactomeId" : 10723347,
    "displayName" : "PTGS2 dimer:PTGS inhibitors",
    "schemaClass" : "Complex",
    "renderableClass" : "ComplexDrug",
    "position" : {
      "x" : 1593,
      "y" : 254
    },
    "minX" : 1495,
    "maxX" : 1659,
    "minY" : 230,
    "maxY" : 272,
    "prop" : {
      "x" : 1533,
      "y" : 236,
      "width" : 120,
      "height" : 36
    },
    "textPosition" : {
      "x" : 1542,
      "y" : 237
    },
    "bgColor" : {
      "r" : 184,
      "g" : 154,
      "b" : 230
    },
    "fgColor" : {
      "r" : 161,
      "g" : 1,
      "b" : 2
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1653,
          "y" : 236
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1653,
          "y" : 236
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 23010,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 23006,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1530,
          "y" : 262
        },
        "to" : {
          "x" : 1495,
          "y" : 268
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1524,
          "y" : 267
        },
        "b" : {
          "x" : 1530,
          "y" : 262
        },
        "c" : {
          "x" : 1522,
          "y" : 259
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1522,
          "y" : 259
        }
      }
    } ]
  }, {
    "id" : 23009,
    "reactomeId" : 10723351,
    "displayName" : "PTGS1 dimer:PTGS Inhibitors",
    "schemaClass" : "Complex",
    "renderableClass" : "ComplexDrug",
    "position" : {
      "x" : 1493,
      "y" : 199
    },
    "minX" : 1434,
    "maxX" : 1558,
    "minY" : 177,
    "maxY" : 268,
    "prop" : {
      "x" : 1434,
      "y" : 183,
      "width" : 118,
      "height" : 33
    },
    "textPosition" : {
      "x" : 1442,
      "y" : 181
    },
    "bgColor" : {
      "r" : 184,
      "g" : 154,
      "b" : 230
    },
    "fgColor" : {
      "r" : 161,
      "g" : 1,
      "b" : 2
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1552,
          "y" : 183
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1552,
          "y" : 183
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 23006,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1493,
          "y" : 219
        },
        "to" : {
          "x" : 1495,
          "y" : 268
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1497,
          "y" : 226
        },
        "b" : {
          "x" : 1493,
          "y" : 219
        },
        "c" : {
          "x" : 1489,
          "y" : 226
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1489,
          "y" : 226
        }
      }
    } ]
  }, {
    "id" : 22959,
    "reactomeId" : 113534,
    "displayName" : "O2",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1203,
      "y" : 367
    },
    "minX" : 1138,
    "maxX" : 1275,
    "minY" : 351,
    "maxY" : 382,
    "prop" : {
      "x" : 1186,
      "y" : 352,
      "width" : 35,
      "height" : 30
    },
    "textPosition" : {
      "x" : 1191,
      "y" : 356
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1216,
          "y" : 357
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1216,
          "y" : 357
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 22958,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1183,
          "y" : 367
        },
        "to" : {
          "x" : 1138,
          "y" : 367
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 1154,
            "y" : 361
          },
          "b" : {
            "x" : 1166,
            "y" : 373
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1160,
            "y" : 367
          }
        }
      }
    }, {
      "edgeId" : 22990,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1224,
          "y" : 366
        },
        "to" : {
          "x" : 1275,
          "y" : 366
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 1243,
            "y" : 360
          },
          "b" : {
            "x" : 1255,
            "y" : 372
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1249,
            "y" : 366
          }
        }
      }
    } ],
    "trivial" : true
  }, {
    "id" : 22960,
    "reactomeId" : 140356,
    "displayName" : "AA",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1200,
      "y" : 325
    },
    "minX" : 1138,
    "maxX" : 1275,
    "minY" : 308,
    "maxY" : 367,
    "prop" : {
      "x" : 1180,
      "y" : 309,
      "width" : 40,
      "height" : 33
    },
    "textPosition" : {
      "x" : 1188,
      "y" : 315
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1215,
          "y" : 314
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1215,
          "y" : 314
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 22958,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1177,
          "y" : 338
        },
        "to" : {
          "x" : 1138,
          "y" : 367
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 22990,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1223,
          "y" : 335
        },
        "to" : {
          "x" : 1275,
          "y" : 366
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 22961,
    "reactomeId" : 140357,
    "displayName" : "PGG2",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1085,
      "y" : 427
    },
    "minX" : 1003,
    "maxX" : 1113,
    "minY" : 411,
    "maxY" : 480,
    "prop" : {
      "x" : 1058,
      "y" : 412,
      "width" : 54,
      "height" : 30
    },
    "textPosition" : {
      "x" : 1064,
      "y" : 416
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1107,
          "y" : 417
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1107,
          "y" : 417
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 22958,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 22990,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 22992,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1084,
          "y" : 445
        },
        "to" : {
          "x" : 1082,
          "y" : 480
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 22963,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1060,
          "y" : 445
        },
        "to" : {
          "x" : 1003,
          "y" : 477
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 22962,
    "reactomeId" : 10658666,
    "displayName" : "PTGS1 dimer",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 883,
      "y" : 367
    },
    "minX" : 832,
    "maxX" : 1488,
    "minY" : 188,
    "maxY" : 519,
    "prop" : {
      "x" : 832,
      "y" : 356,
      "width" : 102,
      "height" : 22
    },
    "textPosition" : {
      "x" : 839,
      "y" : 357
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 934,
          "y" : 356
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 934,
          "y" : 356
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 22958,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 937,
          "y" : 367
        },
        "to" : {
          "x" : 1078,
          "y" : 367
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1082,
          "y" : 367
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1082,
          "y" : 367
        }
      }
    }, {
      "edgeId" : 22963,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 891,
          "y" : 381
        },
        "to" : {
          "x" : 993,
          "y" : 511
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 996,
          "y" : 515
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 996,
          "y" : 515
        }
      }
    }, {
      "edgeId" : 22995,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 882,
          "y" : 353
        },
        "to" : {
          "x" : 882,
          "y" : 273
        }
      }, {
        "from" : {
          "x" : 882,
          "y" : 273
        },
        "to" : {
          "x" : 1069,
          "y" : 188
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 23001,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 876,
          "y" : 381
        },
        "to" : {
          "x" : 848,
          "y" : 424
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 23006,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 932,
          "y" : 353
        },
        "to" : {
          "x" : 1192,
          "y" : 298
        }
      }, {
        "from" : {
          "x" : 1192,
          "y" : 298
        },
        "to" : {
          "x" : 1488,
          "y" : 303
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 22964,
    "reactomeId" : 9915557,
    "displayName" : "hydrogen donor",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 996,
      "y" : 420
    },
    "minX" : 960,
    "maxX" : 1082,
    "minY" : 396,
    "maxY" : 480,
    "prop" : {
      "x" : 960,
      "y" : 397,
      "width" : 73,
      "height" : 46
    },
    "textPosition" : {
      "x" : 961,
      "y" : 402
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1028,
          "y" : 402
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1028,
          "y" : 402
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 22992,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1028,
          "y" : 446
        },
        "to" : {
          "x" : 1082,
          "y" : 480
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 22963,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 998,
          "y" : 446
        },
        "to" : {
          "x" : 1003,
          "y" : 477
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 22965,
    "reactomeId" : 113519,
    "displayName" : "H2O",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1051,
      "y" : 583
    },
    "minX" : 985,
    "maxX" : 1124,
    "minY" : 567,
    "maxY" : 624,
    "prop" : {
      "x" : 1030,
      "y" : 568,
      "width" : 43,
      "height" : 31
    },
    "textPosition" : {
      "x" : 1034,
      "y" : 573
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1068,
          "y" : 573
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1068,
          "y" : 573
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 22992,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1076,
          "y" : 594
        },
        "to" : {
          "x" : 1124,
          "y" : 621
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1084,
          "y" : 594
        },
        "b" : {
          "x" : 1076,
          "y" : 594
        },
        "c" : {
          "x" : 1080,
          "y" : 601
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1080,
          "y" : 601
        }
      }
    }, {
      "edgeId" : 22963,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1027,
          "y" : 596
        },
        "to" : {
          "x" : 985,
          "y" : 624
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1023,
          "y" : 603
        },
        "b" : {
          "x" : 1027,
          "y" : 596
        },
        "c" : {
          "x" : 1019,
          "y" : 597
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1019,
          "y" : 597
        }
      }
    } ],
    "trivial" : true
  }, {
    "id" : 22966,
    "reactomeId" : 30138,
    "displayName" : "PGH2",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1055,
      "y" : 758
    },
    "minX" : 985,
    "maxX" : 1124,
    "minY" : 621,
    "maxY" : 773,
    "prop" : {
      "x" : 1028,
      "y" : 743,
      "width" : 54,
      "height" : 30
    },
    "textPosition" : {
      "x" : 1034,
      "y" : 747
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1077,
          "y" : 748
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1077,
          "y" : 748
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 22979,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 22985,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 22992,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1062,
          "y" : 740
        },
        "to" : {
          "x" : 1124,
          "y" : 621
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1062,
          "y" : 732
        },
        "b" : {
          "x" : 1062,
          "y" : 740
        },
        "c" : {
          "x" : 1069,
          "y" : 736
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1069,
          "y" : 736
        }
      }
    }, {
      "edgeId" : 22963,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1047,
          "y" : 740
        },
        "to" : {
          "x" : 985,
          "y" : 624
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1040,
          "y" : 736
        },
        "b" : {
          "x" : 1047,
          "y" : 740
        },
        "c" : {
          "x" : 1047,
          "y" : 732
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1047,
          "y" : 732
        }
      }
    } ]
  }, {
    "id" : 22967,
    "reactomeId" : 9915551,
    "displayName" : "hydrogen acceptor",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1052,
      "y" : 636
    },
    "minX" : 985,
    "maxX" : 1124,
    "minY" : 614,
    "maxY" : 657,
    "prop" : {
      "x" : 1014,
      "y" : 615,
      "width" : 77,
      "height" : 42
    },
    "textPosition" : {
      "x" : 1017,
      "y" : 618
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1086,
          "y" : 620
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1086,
          "y" : 620
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 22992,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1094,
          "y" : 627
        },
        "to" : {
          "x" : 1124,
          "y" : 621
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1100,
          "y" : 622
        },
        "b" : {
          "x" : 1094,
          "y" : 627
        },
        "c" : {
          "x" : 1102,
          "y" : 630
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1102,
          "y" : 630
        }
      }
    }, {
      "edgeId" : 22963,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1011,
          "y" : 629
        },
        "to" : {
          "x" : 985,
          "y" : 624
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1003,
          "y" : 632
        },
        "b" : {
          "x" : 1011,
          "y" : 629
        },
        "c" : {
          "x" : 1005,
          "y" : 624
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1005,
          "y" : 624
        }
      }
    } ]
  }, {
    "id" : 22969,
    "reactomeId" : 265283,
    "displayName" : "PGH2",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 438,
      "y" : 392
    },
    "minX" : 411,
    "maxX" : 466,
    "minY" : 376,
    "maxY" : 407,
    "prop" : {
      "x" : 411,
      "y" : 377,
      "width" : 54,
      "height" : 30
    },
    "textPosition" : {
      "x" : 417,
      "y" : 381
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 460,
          "y" : 382
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 460,
          "y" : 382
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 22982,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 22988,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 22968,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 22970,
    "reactomeId" : 265287,
    "displayName" : "PGE2",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 672,
      "y" : 673
    },
    "minX" : 645,
    "maxX" : 700,
    "minY" : 657,
    "maxY" : 688,
    "prop" : {
      "x" : 645,
      "y" : 658,
      "width" : 54,
      "height" : 30
    },
    "textPosition" : {
      "x" : 651,
      "y" : 662
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 694,
          "y" : 663
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 694,
          "y" : 663
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 22968,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 22971,
    "reactomeId" : 10689032,
    "displayName" : "PTGES trimer",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 877,
      "y" : 694
    },
    "minX" : 678,
    "maxX" : 912,
    "minY" : 621,
    "maxY" : 710,
    "prop" : {
      "x" : 848,
      "y" : 678,
      "width" : 58,
      "height" : 32
    },
    "textPosition" : {
      "x" : 851,
      "y" : 675
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 906,
          "y" : 678
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 906,
          "y" : 678
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 22968,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 845,
          "y" : 683
        },
        "to" : {
          "x" : 686,
          "y" : 626
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 682,
          "y" : 625
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 682,
          "y" : 625
        }
      }
    } ]
  }, {
    "id" : 22973,
    "reactomeId" : 265287,
    "displayName" : "PGE2",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 314,
      "y" : 540
    },
    "minX" : 217,
    "maxX" : 342,
    "minY" : 524,
    "maxY" : 555,
    "prop" : {
      "x" : 287,
      "y" : 525,
      "width" : 54,
      "height" : 30
    },
    "textPosition" : {
      "x" : 293,
      "y" : 529
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 336,
          "y" : 530
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 336,
          "y" : 530
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 22988,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 22972,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 284,
          "y" : 540
        },
        "to" : {
          "x" : 217,
          "y" : 540
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 22974,
    "reactomeId" : 29364,
    "displayName" : "NADPH",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 252,
      "y" : 573
    },
    "minX" : 217,
    "maxX" : 285,
    "minY" : 540,
    "maxY" : 588,
    "prop" : {
      "x" : 221,
      "y" : 558,
      "width" : 63,
      "height" : 30
    },
    "textPosition" : {
      "x" : 227,
      "y" : 562
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 279,
          "y" : 563
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 279,
          "y" : 563
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 22972,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 236,
          "y" : 555
        },
        "to" : {
          "x" : 217,
          "y" : 540
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 22975,
    "reactomeId" : 70106,
    "displayName" : "H+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 262,
      "y" : 519
    },
    "minX" : 217,
    "maxX" : 281,
    "minY" : 503,
    "maxY" : 540,
    "prop" : {
      "x" : 245,
      "y" : 504,
      "width" : 35,
      "height" : 30
    },
    "textPosition" : {
      "x" : 249,
      "y" : 508
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 275,
          "y" : 509
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 275,
          "y" : 509
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 22972,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 242,
          "y" : 527
        },
        "to" : {
          "x" : 217,
          "y" : 540
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ],
    "trivial" : true
  } ],
  "edges" : [ {
    "id" : 23010,
    "reactomeId" : 10723349,
    "displayName" : "PTGS2 dimer binds PTGS inhibitors",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1656,
      "y" : 351
    },
    "minX" : 1604,
    "maxX" : 1662,
    "minY" : 275,
    "maxY" : 357,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 1656,
        "y" : 353
      },
      "to" : {
        "x" : 1656,
        "y" : 351
      }
    }, {
      "from" : {
        "x" : 1656,
        "y" : 351
      },
      "to" : {
        "x" : 1604,
        "y" : 275
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1611,
        "y" : 278
      },
      "b" : {
        "x" : 1604,
        "y" : 275
      },
      "c" : {
        "x" : 1605,
        "y" : 283
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1605,
        "y" : 283
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1656,
        "y" : 351
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1656,
        "y" : 351
      }
    },
    "inputs" : [ {
      "id" : 23007,
      "points" : [ {
        "x" : 1390,
        "y" : 114
      }, {
        "x" : 1673,
        "y" : 114
      }, {
        "x" : 1675,
        "y" : 324
      } ]
    }, {
      "id" : 22991,
      "points" : [ {
        "x" : 1621,
        "y" : 381
      } ]
    } ],
    "outputs" : [ {
      "id" : 23008
    } ]
  }, {
    "id" : 22979,
    "reactomeId" : 10689019,
    "displayName" : "PGH2 is isomerised to PGD2 by PTGDS",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 963,
      "y" : 892
    },
    "minX" : 953,
    "maxX" : 1044,
    "minY" : 776,
    "maxY" : 1076,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1044,
        "y" : 776
      },
      "to" : {
        "x" : 963,
        "y" : 892
      }
    }, {
      "from" : {
        "x" : 963,
        "y" : 892
      },
      "to" : {
        "x" : 953,
        "y" : 1076
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 949,
        "y" : 1069
      },
      "b" : {
        "x" : 953,
        "y" : 1076
      },
      "c" : {
        "x" : 957,
        "y" : 1069
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 957,
        "y" : 1069
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 957,
        "y" : 886
      },
      "b" : {
        "x" : 969,
        "y" : 898
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 963,
        "y" : 892
      }
    },
    "inputs" : [ {
      "id" : 22966
    } ],
    "outputs" : [ {
      "id" : 22980
    } ],
    "catalysts" : [ {
      "id" : 22981,
      "points" : [ {
        "x" : 903,
        "y" : 891
      } ]
    } ]
  }, {
    "id" : 22982,
    "reactomeId" : 10689040,
    "displayName" : "PGH2 is isomerised to PGD2 by HPGDS",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 437,
      "y" : 465
    },
    "minX" : 431,
    "maxX" : 443,
    "minY" : 410,
    "maxY" : 503,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 437,
        "y" : 410
      },
      "to" : {
        "x" : 437,
        "y" : 465
      }
    }, {
      "from" : {
        "x" : 437,
        "y" : 465
      },
      "to" : {
        "x" : 437,
        "y" : 503
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 433,
        "y" : 496
      },
      "b" : {
        "x" : 437,
        "y" : 503
      },
      "c" : {
        "x" : 441,
        "y" : 496
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 441,
        "y" : 496
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 431,
        "y" : 459
      },
      "b" : {
        "x" : 443,
        "y" : 471
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 437,
        "y" : 465
      }
    },
    "inputs" : [ {
      "id" : 22969
    } ],
    "outputs" : [ {
      "id" : 22983
    } ],
    "catalysts" : [ {
      "id" : 22984,
      "points" : [ {
        "x" : 473,
        "y" : 465
      } ]
    } ]
  }, {
    "id" : 22985,
    "reactomeId" : 10656384,
    "displayName" : "PTGIS, CYP8A1 isomerise PGH2 to PGI2",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1059,
      "y" : 858
    },
    "minX" : 1053,
    "maxX" : 1065,
    "minY" : 776,
    "maxY" : 909,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1055,
        "y" : 776
      },
      "to" : {
        "x" : 1059,
        "y" : 858
      }
    }, {
      "from" : {
        "x" : 1059,
        "y" : 858
      },
      "to" : {
        "x" : 1059,
        "y" : 909
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1055,
        "y" : 902
      },
      "b" : {
        "x" : 1059,
        "y" : 909
      },
      "c" : {
        "x" : 1063,
        "y" : 902
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1063,
        "y" : 902
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 1053,
        "y" : 852
      },
      "b" : {
        "x" : 1065,
        "y" : 864
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1059,
        "y" : 858
      }
    },
    "inputs" : [ {
      "id" : 22966
    } ],
    "outputs" : [ {
      "id" : 22986
    } ],
    "catalysts" : [ {
      "id" : 22987,
      "points" : [ {
        "x" : 1525,
        "y" : 857
      } ]
    } ]
  }, {
    "id" : 22988,
    "reactomeId" : 10667895,
    "displayName" : "Prostaglandin E synthase isomerizes PGH2 to PGE2",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 336,
      "y" : 473
    },
    "minX" : 318,
    "maxX" : 419,
    "minY" : 410,
    "maxY" : 522,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 419,
        "y" : 410
      },
      "to" : {
        "x" : 336,
        "y" : 473
      }
    }, {
      "from" : {
        "x" : 336,
        "y" : 473
      },
      "to" : {
        "x" : 318,
        "y" : 522
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 317,
        "y" : 514
      },
      "b" : {
        "x" : 318,
        "y" : 522
      },
      "c" : {
        "x" : 324,
        "y" : 517
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 324,
        "y" : 517
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 330,
        "y" : 467
      },
      "b" : {
        "x" : 342,
        "y" : 479
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 336,
        "y" : 473
      }
    },
    "inputs" : [ {
      "id" : 22969
    } ],
    "outputs" : [ {
      "id" : 22973
    } ],
    "catalysts" : [ {
      "id" : 22989,
      "points" : [ {
        "x" : 299,
        "y" : 466
      } ]
    } ]
  }, {
    "id" : 22958,
    "reactomeId" : 10658669,
    "displayName" : "Arachidonate is oxidised to PGG2 by PTGS1",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1094,
      "y" : 367
    },
    "minX" : 1087,
    "maxX" : 1138,
    "minY" : 361,
    "maxY" : 409,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1138,
        "y" : 367
      },
      "to" : {
        "x" : 1094,
        "y" : 367
      }
    }, {
      "from" : {
        "x" : 1094,
        "y" : 367
      },
      "to" : {
        "x" : 1087,
        "y" : 409
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1084,
        "y" : 402
      },
      "b" : {
        "x" : 1087,
        "y" : 409
      },
      "c" : {
        "x" : 1092,
        "y" : 403
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1092,
        "y" : 403
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 1088,
        "y" : 361
      },
      "b" : {
        "x" : 1100,
        "y" : 373
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1094,
        "y" : 367
      }
    },
    "inputs" : [ {
      "id" : 22959,
      "points" : [ {
        "x" : 1183,
        "y" : 367
      } ],
      "stoichiometry" : 2
    }, {
      "id" : 22960,
      "points" : [ {
        "x" : 1177,
        "y" : 338
      } ]
    } ],
    "outputs" : [ {
      "id" : 22961
    } ],
    "catalysts" : [ {
      "id" : 22962,
      "points" : [ {
        "x" : 937,
        "y" : 367
      } ]
    } ]
  }, {
    "id" : 22990,
    "reactomeId" : 10690068,
    "displayName" : "Arachidonate is oxidised to PGG2 by PTGS2",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1275,
      "y" : 395
    },
    "minX" : 1115,
    "maxX" : 1281,
    "minY" : 366,
    "maxY" : 422,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1275,
        "y" : 366
      },
      "to" : {
        "x" : 1275,
        "y" : 395
      }
    }, {
      "from" : {
        "x" : 1275,
        "y" : 395
      },
      "to" : {
        "x" : 1115,
        "y" : 422
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1121,
        "y" : 417
      },
      "b" : {
        "x" : 1115,
        "y" : 422
      },
      "c" : {
        "x" : 1122,
        "y" : 425
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1122,
        "y" : 425
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 1269,
        "y" : 389
      },
      "b" : {
        "x" : 1281,
        "y" : 401
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1275,
        "y" : 395
      }
    },
    "inputs" : [ {
      "id" : 22960,
      "points" : [ {
        "x" : 1223,
        "y" : 335
      } ]
    }, {
      "id" : 22959,
      "points" : [ {
        "x" : 1224,
        "y" : 366
      } ],
      "stoichiometry" : 2
    } ],
    "outputs" : [ {
      "id" : 22961
    } ],
    "catalysts" : [ {
      "id" : 22991,
      "points" : [ {
        "x" : 1555,
        "y" : 394
      }, {
        "x" : 1403,
        "y" : 394
      } ]
    } ]
  }, {
    "id" : 22992,
    "reactomeId" : 10690062,
    "displayName" : "PGG2 is reduced to PGH2 by PTGS2",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1096,
      "y" : 524
    },
    "minX" : 1082,
    "maxX" : 1124,
    "minY" : 480,
    "maxY" : 621,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1082,
        "y" : 480
      },
      "to" : {
        "x" : 1096,
        "y" : 524
      }
    }, {
      "from" : {
        "x" : 1096,
        "y" : 524
      },
      "to" : {
        "x" : 1124,
        "y" : 621
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1090,
        "y" : 518
      },
      "b" : {
        "x" : 1102,
        "y" : 530
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1096,
        "y" : 524
      }
    },
    "inputs" : [ {
      "id" : 22961,
      "points" : [ {
        "x" : 1084,
        "y" : 445
      } ]
    }, {
      "id" : 22964,
      "points" : [ {
        "x" : 1028,
        "y" : 446
      } ]
    } ],
    "outputs" : [ {
      "id" : 22966,
      "points" : [ {
        "x" : 1062,
        "y" : 740
      } ]
    }, {
      "id" : 22967,
      "points" : [ {
        "x" : 1094,
        "y" : 627
      } ]
    }, {
      "id" : 22965,
      "points" : [ {
        "x" : 1076,
        "y" : 594
      } ]
    } ],
    "catalysts" : [ {
      "id" : 22991,
      "points" : [ {
        "x" : 1555,
        "y" : 401
      }, {
        "x" : 1295,
        "y" : 434
      } ]
    } ],
    "inhibitors" : [ {
      "id" : 22994,
      "points" : [ {
        "x" : 1568,
        "y" : 500
      }, {
        "x" : 1467,
        "y" : 459
      } ]
    } ],
    "activators" : [ {
      "id" : 22993,
      "points" : [ {
        "x" : 911,
        "y" : 576
      } ]
    } ]
  }, {
    "id" : 22963,
    "reactomeId" : 10658672,
    "displayName" : "PGG2 is reduced to PGH2 by PTGS1",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1003,
      "y" : 524
    },
    "minX" : 985,
    "maxX" : 1009,
    "minY" : 477,
    "maxY" : 624,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1003,
        "y" : 477
      },
      "to" : {
        "x" : 1003,
        "y" : 524
      }
    }, {
      "from" : {
        "x" : 1003,
        "y" : 524
      },
      "to" : {
        "x" : 985,
        "y" : 624
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 997,
        "y" : 518
      },
      "b" : {
        "x" : 1009,
        "y" : 530
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1003,
        "y" : 524
      }
    },
    "inputs" : [ {
      "id" : 22961,
      "points" : [ {
        "x" : 1060,
        "y" : 445
      } ]
    }, {
      "id" : 22964,
      "points" : [ {
        "x" : 998,
        "y" : 446
      } ]
    } ],
    "outputs" : [ {
      "id" : 22965,
      "points" : [ {
        "x" : 1027,
        "y" : 596
      } ]
    }, {
      "id" : 22966,
      "points" : [ {
        "x" : 1047,
        "y" : 740
      } ]
    }, {
      "id" : 22967,
      "points" : [ {
        "x" : 1011,
        "y" : 629
      } ]
    } ],
    "catalysts" : [ {
      "id" : 22962,
      "points" : [ {
        "x" : 891,
        "y" : 381
      } ]
    } ]
  }, {
    "id" : 22995,
    "reactomeId" : 10690075,
    "displayName" : "ASA- acetylates PTGS1",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1069,
      "y" : 158
    },
    "minX" : 1063,
    "maxX" : 1075,
    "minY" : 132,
    "maxY" : 188,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1069,
        "y" : 188
      },
      "to" : {
        "x" : 1069,
        "y" : 158
      }
    }, {
      "from" : {
        "x" : 1069,
        "y" : 158
      },
      "to" : {
        "x" : 1069,
        "y" : 132
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1063,
        "y" : 152
      },
      "b" : {
        "x" : 1075,
        "y" : 164
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1069,
        "y" : 158
      }
    },
    "inputs" : [ {
      "id" : 22962,
      "points" : [ {
        "x" : 882,
        "y" : 353
      }, {
        "x" : 882,
        "y" : 273
      } ]
    }, {
      "id" : 22996,
      "points" : [ {
        "x" : 1120,
        "y" : 176
      } ]
    } ],
    "outputs" : [ {
      "id" : 22997,
      "points" : [ {
        "x" : 972,
        "y" : 182
      } ]
    }, {
      "id" : 22998,
      "points" : [ {
        "x" : 1136,
        "y" : 119
      } ]
    } ]
  }, {
    "id" : 22999,
    "reactomeId" : 10690077,
    "displayName" : "ASA- acetylates PTGS2",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1232,
      "y" : 156
    },
    "minX" : 1226,
    "maxX" : 1238,
    "minY" : 129,
    "maxY" : 184,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1232,
        "y" : 184
      },
      "to" : {
        "x" : 1232,
        "y" : 156
      }
    }, {
      "from" : {
        "x" : 1232,
        "y" : 156
      },
      "to" : {
        "x" : 1233,
        "y" : 129
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1226,
        "y" : 150
      },
      "b" : {
        "x" : 1238,
        "y" : 162
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1232,
        "y" : 156
      }
    },
    "inputs" : [ {
      "id" : 22991,
      "points" : [ {
        "x" : 1583,
        "y" : 381
      }, {
        "x" : 1232,
        "y" : 230
      } ]
    }, {
      "id" : 22996,
      "points" : [ {
        "x" : 1175,
        "y" : 174
      } ]
    } ],
    "outputs" : [ {
      "id" : 22998,
      "points" : [ {
        "x" : 1172,
        "y" : 119
      } ]
    }, {
      "id" : 23000,
      "points" : [ {
        "x" : 1286,
        "y" : 183
      } ]
    } ]
  }, {
    "id" : 22968,
    "reactomeId" : 10689035,
    "displayName" : "PGH2 is isomerised to PGE2 by PTGES",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 671,
      "y" : 621
    },
    "minX" : 468,
    "maxX" : 677,
    "minY" : 403,
    "maxY" : 655,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 468,
        "y" : 403
      },
      "to" : {
        "x" : 664,
        "y" : 491
      }
    }, {
      "from" : {
        "x" : 664,
        "y" : 491
      },
      "to" : {
        "x" : 671,
        "y" : 621
      }
    }, {
      "from" : {
        "x" : 671,
        "y" : 621
      },
      "to" : {
        "x" : 671,
        "y" : 655
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 667,
        "y" : 648
      },
      "b" : {
        "x" : 671,
        "y" : 655
      },
      "c" : {
        "x" : 675,
        "y" : 648
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 675,
        "y" : 648
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 665,
        "y" : 615
      },
      "b" : {
        "x" : 677,
        "y" : 627
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 671,
        "y" : 621
      }
    },
    "inputs" : [ {
      "id" : 22969
    } ],
    "outputs" : [ {
      "id" : 22970
    } ],
    "catalysts" : [ {
      "id" : 22971,
      "points" : [ {
        "x" : 845,
        "y" : 683
      } ]
    } ]
  }, {
    "id" : 23001,
    "reactomeId" : 10722379,
    "displayName" : "PTGS1 dimer binds PTGS1 Inhibitors",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 847,
      "y" : 457
    },
    "minX" : 841,
    "maxX" : 863,
    "minY" : 424,
    "maxY" : 489,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 848,
        "y" : 424
      },
      "to" : {
        "x" : 847,
        "y" : 457
      }
    }, {
      "from" : {
        "x" : 847,
        "y" : 457
      },
      "to" : {
        "x" : 863,
        "y" : 489
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 856,
        "y" : 485
      },
      "b" : {
        "x" : 863,
        "y" : 489
      },
      "c" : {
        "x" : 863,
        "y" : 481
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 863,
        "y" : 481
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 847,
        "y" : 457
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 847,
        "y" : 457
      }
    },
    "inputs" : [ {
      "id" : 23002,
      "points" : [ {
        "x" : 815,
        "y" : 423
      } ]
    }, {
      "id" : 22962,
      "points" : [ {
        "x" : 876,
        "y" : 381
      } ]
    } ],
    "outputs" : [ {
      "id" : 23003
    } ]
  }, {
    "id" : 22972,
    "reactomeId" : 10689026,
    "displayName" : "PGE2 is converted to PGF2a by CBR1",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 171,
      "y" : 540
    },
    "minX" : 94,
    "maxX" : 217,
    "minY" : 534,
    "maxY" : 546,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 217,
        "y" : 540
      },
      "to" : {
        "x" : 171,
        "y" : 540
      }
    }, {
      "from" : {
        "x" : 171,
        "y" : 540
      },
      "to" : {
        "x" : 94,
        "y" : 540
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 165,
        "y" : 534
      },
      "b" : {
        "x" : 177,
        "y" : 546
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 171,
        "y" : 540
      }
    },
    "inputs" : [ {
      "id" : 22973,
      "points" : [ {
        "x" : 284,
        "y" : 540
      } ]
    }, {
      "id" : 22974,
      "points" : [ {
        "x" : 236,
        "y" : 555
      } ]
    }, {
      "id" : 22975,
      "points" : [ {
        "x" : 242,
        "y" : 527
      } ]
    } ],
    "outputs" : [ {
      "id" : 22976,
      "points" : [ {
        "x" : 94,
        "y" : 281
      } ]
    }, {
      "id" : 22977,
      "points" : [ {
        "x" : 83,
        "y" : 565
      } ]
    } ],
    "catalysts" : [ {
      "id" : 22978,
      "points" : [ {
        "x" : 171,
        "y" : 585
      } ]
    } ]
  }, {
    "id" : 23004,
    "reactomeId" : 10690065,
    "displayName" : "PTGS2 dimer binds PTGS2 inhibitors",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1607,
      "y" : 470
    },
    "minX" : 1600,
    "maxX" : 1612,
    "minY" : 434,
    "maxY" : 500,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 1606,
        "y" : 440
      },
      "to" : {
        "x" : 1607,
        "y" : 470
      }
    }, {
      "from" : {
        "x" : 1607,
        "y" : 470
      },
      "to" : {
        "x" : 1609,
        "y" : 500
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1605,
        "y" : 493
      },
      "b" : {
        "x" : 1609,
        "y" : 500
      },
      "c" : {
        "x" : 1613,
        "y" : 493
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1613,
        "y" : 493
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1607,
        "y" : 470
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1607,
        "y" : 470
      }
    },
    "inputs" : [ {
      "id" : 22991,
      "points" : [ {
        "x" : 1608,
        "y" : 409
      } ]
    }, {
      "id" : 23005,
      "points" : [ {
        "x" : 1624,
        "y" : 437
      } ]
    } ],
    "outputs" : [ {
      "id" : 22994
    } ]
  }, {
    "id" : 23006,
    "reactomeId" : 10723353,
    "displayName" : "PTGS1,2 dimers bind PTGS Inhibitors",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1497,
      "y" : 290
    },
    "minX" : 1488,
    "maxX" : 1503,
    "minY" : 268,
    "maxY" : 303,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 1488,
        "y" : 303
      },
      "to" : {
        "x" : 1497,
        "y" : 290
      }
    }, {
      "from" : {
        "x" : 1497,
        "y" : 290
      },
      "to" : {
        "x" : 1495,
        "y" : 268
      }
    } ],
    "reactionShape" : {
      "c" : {
        "x" : 1497,
        "y" : 290
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1497,
        "y" : 290
      }
    },
    "inputs" : [ {
      "id" : 22962,
      "points" : [ {
        "x" : 932,
        "y" : 353
      }, {
        "x" : 1192,
        "y" : 298
      } ]
    }, {
      "id" : 22991,
      "points" : [ {
        "x" : 1594,
        "y" : 381
      } ]
    }, {
      "id" : 23007,
      "points" : [ {
        "x" : 1331,
        "y" : 134
      } ]
    } ],
    "outputs" : [ {
      "id" : 23008,
      "points" : [ {
        "x" : 1530,
        "y" : 262
      } ]
    }, {
      "id" : 23009,
      "points" : [ {
        "x" : 1493,
        "y" : 219
      } ]
    } ]
  } ],
  "compartments" : [ {
    "id" : 23011,
    "reactomeId" : 70101,
    "displayName" : "cytosol",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 868,
      "y" : 642
    },
    "minX" : 0,
    "maxX" : 1736,
    "minY" : 51,
    "maxY" : 1233,
    "prop" : {
      "x" : 0,
      "y" : 51,
      "width" : 1736,
      "height" : 1182
    },
    "textPosition" : {
      "x" : 295,
      "y" : 74
    },
    "insets" : {
      "x" : 10,
      "y" : 61,
      "width" : 1716,
      "height" : 1162
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 23012, 22969, 22976, 22974, 22972, 22977, 22975, 22978, 22973, 22982, 22983, 22984, 22988, 22968, 22970, 22989, 23053, 23054, 23055, 23056, 22995, 22998, 22999, 23001, 23002, 23005, 23007, 23010, 23057, 22996 ]
  }, {
    "id" : 23012,
    "reactomeId" : 17957,
    "displayName" : "endoplasmic reticulum lumen",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 1244,
      "y" : 701
    },
    "minX" : 876,
    "maxX" : 1612,
    "minY" : 197,
    "maxY" : 1206,
    "prop" : {
      "x" : 876,
      "y" : 197,
      "width" : 736,
      "height" : 1009
    },
    "textPosition" : {
      "x" : 907,
      "y" : 253
    },
    "insets" : {
      "x" : 886,
      "y" : 207,
      "width" : 716,
      "height" : 989
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 22958, 22959, 22961, 22966, 22963, 22971, 22979, 22980, 22981, 22985, 22986, 22960, 22990, 22992, 22962, 22994, 22987, 23000, 22997, 22993, 22991, 23003, 23009, 23008, 23004, 23006, 22964, 22965, 22967 ]
  } ],
  "notes" : [ ],
  "links" : [ {
    "id" : 23057,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 1101,
      "y" : 146
    },
    "minX" : 1095,
    "maxX" : 1120,
    "minY" : 44,
    "maxY" : 157,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 1099,
        "y" : 44
      },
      "to" : {
        "x" : 1101,
        "y" : 146
      }
    }, {
      "from" : {
        "x" : 1101,
        "y" : 146
      },
      "to" : {
        "x" : 1120,
        "y" : 157
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1112,
        "y" : 157
      },
      "b" : {
        "x" : 1120,
        "y" : 157
      },
      "c" : {
        "x" : 1116,
        "y" : 150
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 1116,
        "y" : 150
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 1095,
        "y" : 140
      },
      "b" : {
        "x" : 1107,
        "y" : 152
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1101,
        "y" : 146
      }
    },
    "inputs" : [ {
      "id" : 23052
    } ],
    "outputs" : [ {
      "id" : 22996
    } ]
  } ],
  "shadows" : [ ],
  "minX" : 0,
  "maxX" : 1736,
  "minY" : 0,
  "maxY" : 1233,
  "disease" : false
}