{ "dbId" : 10728730, "stableId" : "R-XTR-2142753", "displayName" : "Arachidonate metabolism", "nodes" : [ { "id" : 93441, "reactomeId" : 29364, "displayName" : "NADPH", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 385, "y" : 1222 }, "minX" : 354, "maxX" : 418, "minY" : 1152, "maxY" : 1237, "prop" : { "x" : 354, "y" : 1207, "width" : 63, "height" : 30 }, "textPosition" : { "x" : 360, "y" : 1211 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 412, "y" : 1212 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 412, "y" : 1212 } } }, "connectors" : [ { "edgeId" : 93439, "type" : "INPUT", "segments" : [ { "from" : { "x" : 380, "y" : 1204 }, "to" : { "x" : 365, "y" : 1152 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 93440, "reactomeId" : 70106, "displayName" : "H+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 325, "y" : 1238 }, "minX" : 308, "maxX" : 365, "minY" : 1152, "maxY" : 1253, "prop" : { "x" : 308, "y" : 1223, "width" : 35, "height" : 30 }, "textPosition" : { "x" : 312, "y" : 1227 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 338, "y" : 1228 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 338, "y" : 1228 } } }, "connectors" : [ { "edgeId" : 93439, "type" : "INPUT", "segments" : [ { "from" : { "x" : 331, "y" : 1220 }, "to" : { "x" : 365, "y" : 1152 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 93443, "reactomeId" : 29356, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 267, "y" : 1232 }, "minX" : 245, "maxX" : 302, "minY" : 1152, "maxY" : 1247, "prop" : { "x" : 245, "y" : 1217, "width" : 45, "height" : 30 }, "textPosition" : { "x" : 250, "y" : 1221 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 285, "y" : 1222 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 285, "y" : 1222 } } }, "connectors" : [ { "edgeId" : 93439, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 273, "y" : 1214 }, "to" : { "x" : 302, "y" : 1152 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 272, "y" : 1206 }, "b" : { "x" : 273, "y" : 1214 }, "c" : { "x" : 280, "y" : 1209 }, "type" : "ARROW", "centre" : { "x" : 280, "y" : 1209 } } } ], "trivial" : true }, { "id" : 93442, "reactomeId" : 29368, "displayName" : "O2", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 421, "y" : 1189 }, "minX" : 365, "maxX" : 440, "minY" : 1152, "maxY" : 1204, "prop" : { "x" : 404, "y" : 1174, "width" : 35, "height" : 30 }, "textPosition" : { "x" : 409, "y" : 1178 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 434, "y" : 1179 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 434, "y" : 1179 } } }, "connectors" : [ { "edgeId" : 93439, "type" : "INPUT", "segments" : [ { "from" : { "x" : 401, "y" : 1177 }, "to" : { "x" : 365, "y" : 1152 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 93445, "reactomeId" : 29366, "displayName" : "NADP+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 236, "y" : 1191 }, "minX" : 205, "maxX" : 302, "minY" : 1152, "maxY" : 1206, "prop" : { "x" : 205, "y" : 1176, "width" : 63, "height" : 30 }, "textPosition" : { "x" : 210, "y" : 1180 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 263, "y" : 1181 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 263, "y" : 1181 } } }, "connectors" : [ { "edgeId" : 93439, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 261, "y" : 1173 }, "to" : { "x" : 302, "y" : 1152 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 265, "y" : 1166 }, "b" : { "x" : 261, "y" : 1173 }, "c" : { "x" : 269, "y" : 1173 }, "type" : "ARROW", "centre" : { "x" : 269, "y" : 1173 } } } ] }, { "id" : 93444, "reactomeId" : 2161582, "displayName" : "20cooh-LTB4", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 184, "y" : 1154 }, "minX" : 124, "maxX" : 302, "minY" : 1138, "maxY" : 1169, "prop" : { "x" : 124, "y" : 1139, "width" : 120, "height" : 30 }, "textPosition" : { "x" : 140, "y" : 1143 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 239, "y" : 1144 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 239, "y" : 1144 } } }, "connectors" : [ { "edgeId" : 93439, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 247, "y" : 1152 }, "to" : { "x" : 302, "y" : 1152 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 254, "y" : 1148 }, "b" : { "x" : 247, "y" : 1152 }, "c" : { "x" : 254, "y" : 1156 }, "type" : "ARROW", "centre" : { "x" : 254, "y" : 1156 } } } ] }, { "id" : 93447, "reactomeId" : 266013, "displayName" : "LTC4", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1260, "y" : 1528 }, "minX" : 1233, "maxX" : 1321, "minY" : 1467, "maxY" : 1543, "prop" : { "x" : 1233, "y" : 1513, "width" : 54, "height" : 30 }, "textPosition" : { "x" : 1241, "y" : 1517 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1282, "y" : 1518 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1282, "y" : 1518 } } }, "connectors" : [ { "edgeId" : 93446, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1290, "y" : 1528 }, "to" : { "x" : 1321, "y" : 1529 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 93533, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1259, "y" : 1510 }, "to" : { "x" : 1259, "y" : 1467 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1255, "y" : 1503 }, "b" : { "x" : 1259, "y" : 1510 }, "c" : { "x" : 1263, "y" : 1503 }, "type" : "ARROW", "centre" : { "x" : 1263, "y" : 1503 } } } ] }, { "id" : 93449, "reactomeId" : 210382, "displayName" : "L-Glu", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1399, "y" : 1567 }, "minX" : 1370, "maxX" : 1430, "minY" : 1529, "maxY" : 1582, "prop" : { "x" : 1370, "y" : 1552, "width" : 59, "height" : 30 }, "textPosition" : { "x" : 1380, "y" : 1556 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1424, "y" : 1557 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1424, "y" : 1557 } } }, "connectors" : [ { "edgeId" : 93446, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1389, "y" : 1549 }, "to" : { "x" : 1376, "y" : 1529 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1382, "y" : 1545 }, "b" : { "x" : 1389, "y" : 1549 }, "c" : { "x" : 1389, "y" : 1541 }, "type" : "ARROW", "centre" : { "x" : 1389, "y" : 1541 } } } ] }, { "id" : 93448, "reactomeId" : 109276, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1280, "y" : 1572 }, "minX" : 1259, "maxX" : 1321, "minY" : 1529, "maxY" : 1587, "prop" : { "x" : 1259, "y" : 1557, "width" : 43, "height" : 30 }, "textPosition" : { "x" : 1263, "y" : 1561 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1297, "y" : 1562 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1297, "y" : 1562 } } }, "connectors" : [ { "edgeId" : 93446, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1294, "y" : 1554 }, "to" : { "x" : 1321, "y" : 1529 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 93451, "reactomeId" : 10667991, "displayName" : "GGT1 dimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1343, "y" : 1475 }, "minX" : 1301, "maxX" : 1391, "minY" : 1451, "maxY" : 1521, "prop" : { "x" : 1301, "y" : 1457, "width" : 84, "height" : 36 }, "textPosition" : { "x" : 1303, "y" : 1464 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1385, "y" : 1457 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1385, "y" : 1457 } } }, "connectors" : [ { "edgeId" : 93446, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1343, "y" : 1499 }, "to" : { "x" : 1343, "y" : 1513 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1344, "y" : 1517 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1344, "y" : 1517 } } } ] }, { "id" : 93450, "reactomeId" : 266074, "displayName" : "LTD4", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1435, "y" : 1531 }, "minX" : 1376, "maxX" : 1463, "minY" : 1515, "maxY" : 1546, "prop" : { "x" : 1408, "y" : 1516, "width" : 54, "height" : 30 }, "textPosition" : { "x" : 1416, "y" : 1520 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1457, "y" : 1521 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1457, "y" : 1521 } } }, "connectors" : [ { "edgeId" : 93446, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1405, "y" : 1530 }, "to" : { "x" : 1376, "y" : 1529 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1398, "y" : 1534 }, "b" : { "x" : 1405, "y" : 1530 }, "c" : { "x" : 1398, "y" : 1526 }, "type" : "ARROW", "centre" : { "x" : 1398, "y" : 1526 } } } ] }, { "id" : 93453, "reactomeId" : 113601, "displayName" : "NADPH", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 533, "y" : 777 }, "minX" : 502, "maxX" : 593, "minY" : 761, "maxY" : 909, "prop" : { "x" : 502, "y" : 762, "width" : 63, "height" : 30 }, "textPosition" : { "x" : 508, "y" : 766 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 560, "y" : 767 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 560, "y" : 767 } } }, "connectors" : [ { "edgeId" : 93452, "type" : "INPUT", "segments" : [ { "from" : { "x" : 540, "y" : 795 }, "to" : { "x" : 593, "y" : 897 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 93461, "type" : "INPUT", "segments" : [ { "from" : { "x" : 536, "y" : 795 }, "to" : { "x" : 566, "y" : 909 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 93455, "reactomeId" : 113534, "displayName" : "O2", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 510, "y" : 824 }, "minX" : 493, "maxX" : 593, "minY" : 808, "maxY" : 909, "prop" : { "x" : 493, "y" : 809, "width" : 35, "height" : 30 }, "textPosition" : { "x" : 498, "y" : 813 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 523, "y" : 814 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 523, "y" : 814 } } }, "connectors" : [ { "edgeId" : 93452, "type" : "INPUT", "segments" : [ { "from" : { "x" : 527, "y" : 842 }, "to" : { "x" : 593, "y" : 897 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 93461, "type" : "INPUT", "segments" : [ { "from" : { "x" : 519, "y" : 842 }, "to" : { "x" : 566, "y" : 909 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 93454, "reactomeId" : 140356, "displayName" : "AA", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 693, "y" : 547 }, "minX" : 566, "maxX" : 714, "minY" : 530, "maxY" : 909, "prop" : { "x" : 673, "y" : 531, "width" : 40, "height" : 33 }, "textPosition" : { "x" : 681, "y" : 537 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 708, "y" : 536 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 708, "y" : 536 } } }, "connectors" : [ { "edgeId" : 93452, "type" : "INPUT", "segments" : [ { "from" : { "x" : 688, "y" : 567 }, "to" : { "x" : 593, "y" : 897 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 93461, "type" : "INPUT", "segments" : [ { "from" : { "x" : 687, "y" : 567 }, "to" : { "x" : 566, "y" : 909 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 93457, "reactomeId" : 113564, "displayName" : "NADP+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 632, "y" : 1045 }, "minX" : 565, "maxX" : 665, "minY" : 970, "maxY" : 1060, "prop" : { "x" : 601, "y" : 1030, "width" : 63, "height" : 30 }, "textPosition" : { "x" : 606, "y" : 1034 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 659, "y" : 1035 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 659, "y" : 1035 } } }, "connectors" : [ { "edgeId" : 93452, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 624, "y" : 1027 }, "to" : { "x" : 592, "y" : 970 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 617, "y" : 1023 }, "b" : { "x" : 624, "y" : 1027 }, "c" : { "x" : 624, "y" : 1019 }, "type" : "ARROW", "centre" : { "x" : 624, "y" : 1019 } } }, { "edgeId" : 93461, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 616, "y" : 1027 }, "to" : { "x" : 565, "y" : 982 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 608, "y" : 1025 }, "b" : { "x" : 616, "y" : 1027 }, "c" : { "x" : 613, "y" : 1019 }, "type" : "ARROW", "centre" : { "x" : 613, "y" : 1019 } } } ], "trivial" : true }, { "id" : 93456, "reactomeId" : 156540, "displayName" : "H+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 586, "y" : 735 }, "minX" : 566, "maxX" : 605, "minY" : 719, "maxY" : 909, "prop" : { "x" : 569, "y" : 720, "width" : 35, "height" : 30 }, "textPosition" : { "x" : 573, "y" : 724 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 599, "y" : 725 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 599, "y" : 725 } } }, "connectors" : [ { "edgeId" : 93452, "type" : "INPUT", "segments" : [ { "from" : { "x" : 586, "y" : 753 }, "to" : { "x" : 593, "y" : 897 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 93461, "type" : "INPUT", "segments" : [ { "from" : { "x" : 584, "y" : 753 }, "to" : { "x" : 566, "y" : 909 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 93459, "reactomeId" : 113519, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 554, "y" : 1042 }, "minX" : 532, "maxX" : 592, "minY" : 970, "maxY" : 1057, "prop" : { "x" : 532, "y" : 1027, "width" : 45, "height" : 30 }, "textPosition" : { "x" : 537, "y" : 1031 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 572, "y" : 1032 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 572, "y" : 1032 } } }, "connectors" : [ { "edgeId" : 93452, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 561, "y" : 1024 }, "to" : { "x" : 592, "y" : 970 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 561, "y" : 1016 }, "b" : { "x" : 561, "y" : 1024 }, "c" : { "x" : 568, "y" : 1020 }, "type" : "ARROW", "centre" : { "x" : 568, "y" : 1020 } } }, { "edgeId" : 93461, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 556, "y" : 1024 }, "to" : { "x" : 565, "y" : 982 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 554, "y" : 1016 }, "b" : { "x" : 556, "y" : 1024 }, "c" : { "x" : 561, "y" : 1018 }, "type" : "ARROW", "centre" : { "x" : 561, "y" : 1018 } } } ], "trivial" : true }, { "id" : 93458, "reactomeId" : 2142836, "displayName" : "19-HETE", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 765, "y" : 998 }, "minX" : 592, "maxX" : 807, "minY" : 970, "maxY" : 1013, "prop" : { "x" : 724, "y" : 983, "width" : 82, "height" : 30 }, "textPosition" : { "x" : 735, "y" : 987 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 801, "y" : 988 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 801, "y" : 988 } } }, "connectors" : [ { "edgeId" : 93452, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 721, "y" : 991 }, "to" : { "x" : 592, "y" : 970 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 714, "y" : 994 }, "b" : { "x" : 721, "y" : 991 }, "c" : { "x" : 715, "y" : 986 }, "type" : "ARROW", "centre" : { "x" : 715, "y" : 986 } } } ] }, { "id" : 93460, "reactomeId" : 10689068, "displayName" : "CYP(2)", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 461, "y" : 921 }, "minX" : 434, "maxX" : 585, "minY" : 910, "maxY" : 934, "prop" : { "x" : 434, "y" : 910, "width" : 55, "height" : 22 }, "textPosition" : { "x" : 437, "y" : 910 }, "connectors" : [ { "edgeId" : 93452, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 495, "y" : 923 }, "to" : { "x" : 577, "y" : 930 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 581, "y" : 930 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 581, "y" : 930 } } } ] }, { "id" : 93463, "reactomeId" : 10689078, "displayName" : "CYP(3)", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 460, "y" : 987 }, "minX" : 433, "maxX" : 559, "minY" : 944, "maxY" : 998, "prop" : { "x" : 433, "y" : 976, "width" : 55, "height" : 22 }, "textPosition" : { "x" : 436, "y" : 976 }, "connectors" : [ { "edgeId" : 93461, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 487, "y" : 970 }, "to" : { "x" : 551, "y" : 949 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 555, "y" : 948 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 555, "y" : 948 } } } ] }, { "id" : 93462, "reactomeId" : 2142780, "displayName" : "20-HETE", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 755, "y" : 1034 }, "minX" : 565, "maxX" : 797, "minY" : 982, "maxY" : 1049, "prop" : { "x" : 714, "y" : 1019, "width" : 82, "height" : 30 }, "textPosition" : { "x" : 725, "y" : 1023 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 791, "y" : 1024 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 791, "y" : 1024 } } }, "connectors" : [ { "edgeId" : 93461, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 711, "y" : 1022 }, "to" : { "x" : 565, "y" : 982 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 703, "y" : 1024 }, "b" : { "x" : 711, "y" : 1022 }, "c" : { "x" : 705, "y" : 1016 }, "type" : "ARROW", "centre" : { "x" : 705, "y" : 1016 } } } ] }, { "id" : 93465, "reactomeId" : 70106, "displayName" : "H+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1131, "y" : 584 }, "minX" : 1077, "maxX" : 1150, "minY" : 568, "maxY" : 599, "prop" : { "x" : 1114, "y" : 569, "width" : 35, "height" : 30 }, "textPosition" : { "x" : 1118, "y" : 573 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1144, "y" : 574 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1144, "y" : 574 } } }, "connectors" : [ { "edgeId" : 93464, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1111, "y" : 586 }, "to" : { "x" : 1077, "y" : 593 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 93467, "reactomeId" : 29368, "displayName" : "O2", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1163, "y" : 637 }, "minX" : 1077, "maxX" : 1229, "minY" : 593, "maxY" : 716, "prop" : { "x" : 1146, "y" : 622, "width" : 35, "height" : 30 }, "textPosition" : { "x" : 1151, "y" : 626 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1176, "y" : 627 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1176, "y" : 627 } } }, "connectors" : [ { "edgeId" : 93464, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1143, "y" : 628 }, "to" : { "x" : 1077, "y" : 593 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 93472, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1175, "y" : 655 }, "to" : { "x" : 1229, "y" : 716 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 93466, "reactomeId" : 29364, "displayName" : "NADPH", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1018, "y" : 601 }, "minX" : 987, "maxX" : 1077, "minY" : 585, "maxY" : 616, "prop" : { "x" : 987, "y" : 586, "width" : 63, "height" : 30 }, "textPosition" : { "x" : 993, "y" : 590 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1045, "y" : 591 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1045, "y" : 591 } } }, "connectors" : [ { "edgeId" : 93464, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1053, "y" : 596 }, "to" : { "x" : 1077, "y" : 593 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 93469, "reactomeId" : 2142738, "displayName" : "15R-HETE", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1076, "y" : 492 }, "minX" : 1030, "maxX" : 1123, "minY" : 476, "maxY" : 551, "prop" : { "x" : 1030, "y" : 477, "width" : 92, "height" : 30 }, "textPosition" : { "x" : 1042, "y" : 481 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1117, "y" : 482 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1117, "y" : 482 } } }, "connectors" : [ { "edgeId" : 93464, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1076, "y" : 510 }, "to" : { "x" : 1077, "y" : 551 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1080, "y" : 517 }, "b" : { "x" : 1076, "y" : 510 }, "c" : { "x" : 1072, "y" : 517 }, "type" : "ARROW", "centre" : { "x" : 1072, "y" : 517 } } } ] }, { "id" : 93468, "reactomeId" : 29356, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1032, "y" : 528 }, "minX" : 1010, "maxX" : 1077, "minY" : 512, "maxY" : 551, "prop" : { "x" : 1010, "y" : 513, "width" : 45, "height" : 30 }, "textPosition" : { "x" : 1015, "y" : 517 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1050, "y" : 518 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1050, "y" : 518 } } }, "connectors" : [ { "edgeId" : 93464, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1058, "y" : 539 }, "to" : { "x" : 1077, "y" : 551 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1066, "y" : 539 }, "b" : { "x" : 1058, "y" : 539 }, "c" : { "x" : 1062, "y" : 546 }, "type" : "ARROW", "centre" : { "x" : 1062, "y" : 546 } } } ], "trivial" : true }, { "id" : 93471, "reactomeId" : 10689109, "displayName" : "Ac-PTGS2 dimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 971, "y" : 499 }, "minX" : 934, "maxX" : 1069, "minY" : 477, "maxY" : 576, "prop" : { "x" : 934, "y" : 483, "width" : 74, "height" : 33 }, "textPosition" : { "x" : 935, "y" : 481 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1008, "y" : 483 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1008, "y" : 483 } } }, "connectors" : [ { "edgeId" : 93464, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 982, "y" : 519 }, "to" : { "x" : 1021, "y" : 572 } }, { "from" : { "x" : 1021, "y" : 572 }, "to" : { "x" : 1061, "y" : 572 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1065, "y" : 572 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1065, "y" : 572 } } } ] }, { "id" : 93470, "reactomeId" : 29366, "displayName" : "NADP+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1132, "y" : 532 }, "minX" : 1077, "maxX" : 1165, "minY" : 516, "maxY" : 551, "prop" : { "x" : 1101, "y" : 517, "width" : 63, "height" : 30 }, "textPosition" : { "x" : 1106, "y" : 521 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1159, "y" : 522 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1159, "y" : 522 } } }, "connectors" : [ { "edgeId" : 93464, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1098, "y" : 542 }, "to" : { "x" : 1077, "y" : 551 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1093, "y" : 548 }, "b" : { "x" : 1098, "y" : 542 }, "c" : { "x" : 1090, "y" : 541 }, "type" : "ARROW", "centre" : { "x" : 1090, "y" : 541 } } } ] }, { "id" : 93473, "reactomeId" : 2142718, "displayName" : "15S-HpETE", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1259, "y" : 606 }, "minX" : 1209, "maxX" : 1311, "minY" : 562, "maxY" : 621, "prop" : { "x" : 1209, "y" : 591, "width" : 101, "height" : 30 }, "textPosition" : { "x" : 1221, "y" : 595 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1305, "y" : 596 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1305, "y" : 596 } } }, "connectors" : [ { "edgeId" : 93472, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 93475, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1259, "y" : 588 }, "to" : { "x" : 1259, "y" : 562 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 93474, "reactomeId" : 10689132, "displayName" : "ALOX15B:Fe2+", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1327, "y" : 680 }, "minX" : 1238, "maxX" : 1384, "minY" : 663, "maxY" : 691, "prop" : { "x" : 1276, "y" : 669, "width" : 102, "height" : 22 }, "textPosition" : { "x" : 1277, "y" : 669 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1378, "y" : 669 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1378, "y" : 669 } } }, "connectors" : [ { "edgeId" : 93472, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1270, "y" : 680 }, "to" : { "x" : 1246, "y" : 680 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1242, "y" : 680 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1242, "y" : 680 } } } ] }, { "id" : 93477, "reactomeId" : 29356, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1314, "y" : 494 }, "minX" : 1257, "maxX" : 1338, "minY" : 478, "maxY" : 509, "prop" : { "x" : 1292, "y" : 479, "width" : 45, "height" : 30 }, "textPosition" : { "x" : 1297, "y" : 483 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1332, "y" : 484 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1332, "y" : 484 } } }, "connectors" : [ { "edgeId" : 93475, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1289, "y" : 496 }, "to" : { "x" : 1257, "y" : 501 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1283, "y" : 501 }, "b" : { "x" : 1289, "y" : 496 }, "c" : { "x" : 1282, "y" : 493 }, "type" : "ARROW", "centre" : { "x" : 1282, "y" : 493 } } } ], "trivial" : true }, { "id" : 93476, "reactomeId" : 29450, "displayName" : "GSH", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1197, "y" : 573 }, "minX" : 1175, "maxX" : 1259, "minY" : 557, "maxY" : 588, "prop" : { "x" : 1175, "y" : 558, "width" : 45, "height" : 30 }, "textPosition" : { "x" : 1180, "y" : 562 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1215, "y" : 563 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1215, "y" : 563 } } }, "connectors" : [ { "edgeId" : 93475, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1223, "y" : 569 }, "to" : { "x" : 1259, "y" : 562 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 1235, "y" : 559 }, "b" : { "x" : 1247, "y" : 571 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1241, "y" : 565 } } } } ] }, { "id" : 93479, "reactomeId" : 111745, "displayName" : "GSSG", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1188, "y" : 490 }, "minX" : 1161, "maxX" : 1257, "minY" : 474, "maxY" : 505, "prop" : { "x" : 1161, "y" : 475, "width" : 54, "height" : 30 }, "textPosition" : { "x" : 1167, "y" : 479 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1210, "y" : 480 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1210, "y" : 480 } } }, "connectors" : [ { "edgeId" : 93475, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1218, "y" : 494 }, "to" : { "x" : 1257, "y" : 501 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1226, "y" : 491 }, "b" : { "x" : 1218, "y" : 494 }, "c" : { "x" : 1224, "y" : 499 }, "type" : "ARROW", "centre" : { "x" : 1224, "y" : 499 } } } ] }, { "id" : 93478, "reactomeId" : 2142707, "displayName" : "15S-HETE", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1257, "y" : 461 }, "minX" : 1211, "maxX" : 1304, "minY" : 445, "maxY" : 501, "prop" : { "x" : 1211, "y" : 446, "width" : 92, "height" : 30 }, "textPosition" : { "x" : 1223, "y" : 450 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1298, "y" : 451 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1298, "y" : 451 } } }, "connectors" : [ { "edgeId" : 93475, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1257, "y" : 479 }, "to" : { "x" : 1257, "y" : 501 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1261, "y" : 486 }, "b" : { "x" : 1257, "y" : 479 }, "c" : { "x" : 1253, "y" : 486 }, "type" : "ARROW", "centre" : { "x" : 1253, "y" : 486 } } } ] }, { "id" : 93480, "reactomeId" : 10689060, "displayName" : "GPX1/2/4", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 1333, "y" : 538 }, "minX" : 1266, "maxX" : 1375, "minY" : 527, "maxY" : 549, "prop" : { "x" : 1291, "y" : 527, "width" : 84, "height" : 22 }, "textPosition" : { "x" : 1301, "y" : 527 }, "connectors" : [ { "edgeId" : 93475, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1285, "y" : 536 }, "to" : { "x" : 1274, "y" : 536 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1270, "y" : 535 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1270, "y" : 535 } } } ] }, { "id" : 93483, "reactomeId" : 2142739, "displayName" : "5,6-EET", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 964, "y" : 226 }, "minX" : 926, "maxX" : 1075, "minY" : 210, "maxY" : 241, "prop" : { "x" : 926, "y" : 211, "width" : 77, "height" : 30 }, "textPosition" : { "x" : 937, "y" : 215 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 998, "y" : 216 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 998, "y" : 216 } } }, "connectors" : [ { "edgeId" : 93481, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1006, "y" : 227 }, "to" : { "x" : 1075, "y" : 229 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 93482, "reactomeId" : 29356, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1048, "y" : 278 }, "minX" : 1027, "maxX" : 1075, "minY" : 78, "maxY" : 294, "prop" : { "x" : 1027, "y" : 263, "width" : 43, "height" : 31 }, "textPosition" : { "x" : 1031, "y" : 268 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1065, "y" : 268 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1065, "y" : 268 } } }, "connectors" : [ { "edgeId" : 93540, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1052, "y" : 260 }, "to" : { "x" : 1073, "y" : 182 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 93543, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1047, "y" : 260 }, "to" : { "x" : 1043, "y" : 78 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 93481, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1056, "y" : 260 }, "to" : { "x" : 1075, "y" : 229 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 93546, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1049, "y" : 260 }, "to" : { "x" : 1060, "y" : 134 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 93485, "reactomeId" : 10689123, "displayName" : "EPHX2 dimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1169, "y" : 273 }, "minX" : 1104, "maxX" : 1226, "minY" : 87, "maxY" : 284, "prop" : { "x" : 1118, "y" : 262, "width" : 102, "height" : 22 }, "textPosition" : { "x" : 1125, "y" : 263 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1220, "y" : 262 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1220, "y" : 262 } } }, "connectors" : [ { "edgeId" : 93540, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1161, "y" : 259 }, "to" : { "x" : 1116, "y" : 196 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1114, "y" : 193 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1114, "y" : 193 } } }, { "edgeId" : 93543, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1165, "y" : 259 }, "to" : { "x" : 1109, "y" : 95 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1108, "y" : 91 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1108, "y" : 91 } } }, { "edgeId" : 93481, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1152, "y" : 259 }, "to" : { "x" : 1117, "y" : 238 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1113, "y" : 236 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1113, "y" : 236 } } }, { "edgeId" : 93546, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1164, "y" : 259 }, "to" : { "x" : 1114, "y" : 150 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1112, "y" : 146 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1112, "y" : 146 } } } ] }, { "id" : 93484, "reactomeId" : 2142682, "displayName" : "5,6-DHET", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1273, "y" : 231 }, "minX" : 1235, "maxX" : 1313, "minY" : 215, "maxY" : 247, "prop" : { "x" : 1235, "y" : 216, "width" : 77, "height" : 31 }, "textPosition" : { "x" : 1241, "y" : 221 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1307, "y" : 221 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1307, "y" : 221 } } }, "connectors" : [ { "edgeId" : 93481, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 93487, "reactomeId" : 29368, "displayName" : "O2", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1448, "y" : 724 }, "minX" : 1402, "maxX" : 1467, "minY" : 702, "maxY" : 739, "prop" : { "x" : 1431, "y" : 709, "width" : 35, "height" : 30 }, "textPosition" : { "x" : 1436, "y" : 713 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1461, "y" : 714 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1461, "y" : 714 } } }, "connectors" : [ { "edgeId" : 93486, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1428, "y" : 715 }, "to" : { "x" : 1402, "y" : 702 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 93489, "reactomeId" : 10689097, "displayName" : "ALOX12B:Fe2+", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1500, "y" : 674 }, "minX" : 1410, "maxX" : 1564, "minY" : 657, "maxY" : 685, "prop" : { "x" : 1442, "y" : 663, "width" : 116, "height" : 22 }, "textPosition" : { "x" : 1450, "y" : 664 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1558, "y" : 663 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1558, "y" : 663 } } }, "connectors" : [ { "edgeId" : 93486, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1439, "y" : 675 }, "to" : { "x" : 1418, "y" : 676 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1414, "y" : 676 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1414, "y" : 676 } } } ] }, { "id" : 93488, "reactomeId" : 2142790, "displayName" : "12R-HpETE", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1498, "y" : 576 }, "minX" : 1448, "maxX" : 1550, "minY" : 518, "maxY" : 591, "prop" : { "x" : 1448, "y" : 561, "width" : 101, "height" : 30 }, "textPosition" : { "x" : 1460, "y" : 565 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1544, "y" : 566 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1544, "y" : 566 } } }, "connectors" : [ { "edgeId" : 93527, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 93486, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 93490, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1496, "y" : 558 }, "to" : { "x" : 1494, "y" : 518 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 93491, "reactomeId" : 29450, "displayName" : "GSH", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1579, "y" : 557 }, "minX" : 1494, "maxX" : 1666, "minY" : 518, "maxY" : 572, "prop" : { "x" : 1557, "y" : 542, "width" : 45, "height" : 30 }, "textPosition" : { "x" : 1562, "y" : 546 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1597, "y" : 547 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1597, "y" : 547 } } }, "connectors" : [ { "edgeId" : 93490, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1554, "y" : 546 }, "to" : { "x" : 1494, "y" : 518 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 1518, "y" : 526 }, "b" : { "x" : 1530, "y" : 538 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1524, "y" : 532 } } } }, { "edgeId" : 93496, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1605, "y" : 547 }, "to" : { "x" : 1666, "y" : 519 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 1629, "y" : 527 }, "b" : { "x" : 1641, "y" : 539 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1635, "y" : 533 } } } } ] }, { "id" : 93493, "reactomeId" : 111745, "displayName" : "GSSG", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1579, "y" : 458 }, "minX" : 1493, "maxX" : 1666, "minY" : 442, "maxY" : 474, "prop" : { "x" : 1552, "y" : 443, "width" : 54, "height" : 30 }, "textPosition" : { "x" : 1558, "y" : 447 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1601, "y" : 448 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1601, "y" : 448 } } }, "connectors" : [ { "edgeId" : 93490, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1549, "y" : 463 }, "to" : { "x" : 1493, "y" : 474 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1543, "y" : 468 }, "b" : { "x" : 1549, "y" : 463 }, "c" : { "x" : 1541, "y" : 460 }, "type" : "ARROW", "centre" : { "x" : 1541, "y" : 460 } } }, { "edgeId" : 93496, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1609, "y" : 462 }, "to" : { "x" : 1666, "y" : 472 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1617, "y" : 459 }, "b" : { "x" : 1609, "y" : 462 }, "c" : { "x" : 1615, "y" : 467 }, "type" : "ARROW", "centre" : { "x" : 1615, "y" : 467 } } } ] }, { "id" : 93492, "reactomeId" : 2142716, "displayName" : "12R-HETE", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1494, "y" : 416 }, "minX" : 1448, "maxX" : 1541, "minY" : 400, "maxY" : 474, "prop" : { "x" : 1448, "y" : 401, "width" : 92, "height" : 30 }, "textPosition" : { "x" : 1460, "y" : 405 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1535, "y" : 406 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1535, "y" : 406 } } }, "connectors" : [ { "edgeId" : 93490, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1493, "y" : 434 }, "to" : { "x" : 1493, "y" : 474 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1497, "y" : 441 }, "b" : { "x" : 1493, "y" : 434 }, "c" : { "x" : 1489, "y" : 441 }, "type" : "ARROW", "centre" : { "x" : 1489, "y" : 441 } } } ] }, { "id" : 93495, "reactomeId" : 10689114, "displayName" : "GPX1/2/4", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 1579, "y" : 505 }, "minX" : 1502, "maxX" : 1659, "minY" : 494, "maxY" : 516, "prop" : { "x" : 1537, "y" : 494, "width" : 84, "height" : 22 }, "textPosition" : { "x" : 1547, "y" : 494 }, "connectors" : [ { "edgeId" : 93490, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1531, "y" : 502 }, "to" : { "x" : 1510, "y" : 501 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1506, "y" : 501 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1506, "y" : 501 } } }, { "edgeId" : 93496, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1627, "y" : 503 }, "to" : { "x" : 1651, "y" : 502 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1655, "y" : 502 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1655, "y" : 502 } } } ] }, { "id" : 93494, "reactomeId" : 29356, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1579, "y" : 413 }, "minX" : 1493, "maxX" : 1666, "minY" : 397, "maxY" : 474, "prop" : { "x" : 1557, "y" : 398, "width" : 45, "height" : 30 }, "textPosition" : { "x" : 1562, "y" : 402 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1597, "y" : 403 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1597, "y" : 403 } } }, "connectors" : [ { "edgeId" : 93490, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1557, "y" : 431 }, "to" : { "x" : 1493, "y" : 474 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1553, "y" : 438 }, "b" : { "x" : 1557, "y" : 431 }, "c" : { "x" : 1549, "y" : 432 }, "type" : "ARROW", "centre" : { "x" : 1549, "y" : 432 } } }, { "edgeId" : 93496, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1601, "y" : 431 }, "to" : { "x" : 1666, "y" : 472 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1609, "y" : 431 }, "b" : { "x" : 1601, "y" : 431 }, "c" : { "x" : 1605, "y" : 438 }, "type" : "ARROW", "centre" : { "x" : 1605, "y" : 438 } } } ], "trivial" : true }, { "id" : 93497, "reactomeId" : 2142811, "displayName" : "12S-HpETE", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1668, "y" : 574 }, "minX" : 1618, "maxX" : 1720, "minY" : 519, "maxY" : 589, "prop" : { "x" : 1618, "y" : 559, "width" : 101, "height" : 30 }, "textPosition" : { "x" : 1630, "y" : 563 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1714, "y" : 564 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1714, "y" : 564 } } }, "connectors" : [ { "edgeId" : 93496, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1667, "y" : 556 }, "to" : { "x" : 1666, "y" : 519 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 93498, "reactomeId" : 2142678, "displayName" : "12S-HETE", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1667, "y" : 414 }, "minX" : 1621, "maxX" : 1714, "minY" : 398, "maxY" : 472, "prop" : { "x" : 1621, "y" : 399, "width" : 92, "height" : 30 }, "textPosition" : { "x" : 1633, "y" : 403 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1708, "y" : 404 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1708, "y" : 404 } } }, "connectors" : [ { "edgeId" : 93496, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1666, "y" : 432 }, "to" : { "x" : 1666, "y" : 472 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1670, "y" : 439 }, "b" : { "x" : 1666, "y" : 432 }, "c" : { "x" : 1662, "y" : 439 }, "type" : "ARROW", "centre" : { "x" : 1662, "y" : 439 } } } ] }, { "id" : 93501, "reactomeId" : 29356, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1076, "y" : 652 }, "minX" : 1024, "maxX" : 1099, "minY" : 636, "maxY" : 668, "prop" : { "x" : 1055, "y" : 637, "width" : 43, "height" : 31 }, "textPosition" : { "x" : 1059, "y" : 642 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1093, "y" : 642 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1093, "y" : 642 } } }, "connectors" : [ { "edgeId" : 93499, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1052, "y" : 652 }, "to" : { "x" : 1024, "y" : 654 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 93500, "reactomeId" : 9915525, "displayName" : "AA-PC", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 961, "y" : 633 }, "minX" : 934, "maxX" : 1024, "minY" : 617, "maxY" : 654, "prop" : { "x" : 934, "y" : 618, "width" : 55, "height" : 31 }, "textPosition" : { "x" : 939, "y" : 623 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 984, "y" : 623 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 984, "y" : 623 } } }, "connectors" : [ { "edgeId" : 93499, "type" : "INPUT", "segments" : [ { "from" : { "x" : 992, "y" : 642 }, "to" : { "x" : 1024, "y" : 654 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 93503, "reactomeId" : 70106, "displayName" : "H+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1096, "y" : 711 }, "minX" : 1026, "maxX" : 1115, "minY" : 695, "maxY" : 726, "prop" : { "x" : 1079, "y" : 696, "width" : 35, "height" : 30 }, "textPosition" : { "x" : 1083, "y" : 700 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1109, "y" : 701 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1109, "y" : 701 } } }, "connectors" : [ { "edgeId" : 93499, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1076, "y" : 713 }, "to" : { "x" : 1026, "y" : 719 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1070, "y" : 718 }, "b" : { "x" : 1076, "y" : 713 }, "c" : { "x" : 1069, "y" : 710 }, "type" : "ARROW", "centre" : { "x" : 1069, "y" : 710 } } } ], "trivial" : true }, { "id" : 93502, "reactomeId" : 6814253, "displayName" : "LysoPtdCho", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 965, "y" : 729 }, "minX" : 937, "maxX" : 1026, "minY" : 712, "maxY" : 746, "prop" : { "x" : 937, "y" : 713, "width" : 57, "height" : 33 }, "textPosition" : { "x" : 937, "y" : 712 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 989, "y" : 718 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 989, "y" : 718 } } }, "connectors" : [ { "edgeId" : 93499, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 997, "y" : 724 }, "to" : { "x" : 1026, "y" : 719 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1003, "y" : 719 }, "b" : { "x" : 997, "y" : 724 }, "c" : { "x" : 1005, "y" : 727 }, "type" : "ARROW", "centre" : { "x" : 1005, "y" : 727 } } } ] }, { "id" : 93504, "reactomeId" : 10657627, "displayName" : "Active PLA2:phosphatidylcholine", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 930, "y" : 677 }, "minX" : 868, "maxX" : 1017, "minY" : 653, "maxY" : 696, "prop" : { "x" : 868, "y" : 659, "width" : 124, "height" : 37 }, "textPosition" : { "x" : 871, "y" : 647 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 992, "y" : 659 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 992, "y" : 659 } } }, "connectors" : [ { "edgeId" : 93499, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 995, "y" : 680 }, "to" : { "x" : 1009, "y" : 681 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1013, "y" : 681 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1013, "y" : 681 } } } ] }, { "id" : 93507, "reactomeId" : 192172, "displayName" : "Acyl-CoA", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 605, "y" : 435 }, "minX" : 560, "maxX" : 637, "minY" : 419, "maxY" : 482, "prop" : { "x" : 574, "y" : 420, "width" : 62, "height" : 31 }, "textPosition" : { "x" : 575, "y" : 425 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 631, "y" : 425 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 631, "y" : 425 } } }, "connectors" : [ { "edgeId" : 93505, "type" : "INPUT", "segments" : [ { "from" : { "x" : 590, "y" : 454 }, "to" : { "x" : 560, "y" : 482 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 93506, "reactomeId" : 5696426, "displayName" : "ARACOH", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 525, "y" : 436 }, "minX" : 496, "maxX" : 560, "minY" : 421, "maxY" : 482, "prop" : { "x" : 496, "y" : 422, "width" : 58, "height" : 28 }, "textPosition" : { "x" : 496, "y" : 425 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 549, "y" : 427 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 549, "y" : 427 } } }, "connectors" : [ { "edgeId" : 93505, "type" : "INPUT", "segments" : [ { "from" : { "x" : 535, "y" : 453 }, "to" : { "x" : 560, "y" : 482 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 93509, "reactomeId" : 5696412, "displayName" : "arachidyl ester", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 599, "y" : 583 }, "minX" : 560, "maxX" : 633, "minY" : 533, "maxY" : 602, "prop" : { "x" : 567, "y" : 564, "width" : 65, "height" : 38 }, "textPosition" : { "x" : 566, "y" : 565 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 627, "y" : 569 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 627, "y" : 569 } } }, "connectors" : [ { "edgeId" : 93505, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 584, "y" : 561 }, "to" : { "x" : 560, "y" : 533 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 576, "y" : 558 }, "b" : { "x" : 584, "y" : 561 }, "c" : { "x" : 583, "y" : 553 }, "type" : "ARROW", "centre" : { "x" : 583, "y" : 553 } } } ] }, { "id" : 93508, "reactomeId" : 162743, "displayName" : "CoA-SH", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 511, "y" : 581 }, "minX" : 485, "maxX" : 560, "minY" : 533, "maxY" : 596, "prop" : { "x" : 485, "y" : 566, "width" : 53, "height" : 30 }, "textPosition" : { "x" : 485, "y" : 570 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 533, "y" : 571 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 533, "y" : 571 } } }, "connectors" : [ { "edgeId" : 93505, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 526, "y" : 563 }, "to" : { "x" : 560, "y" : 533 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 529, "y" : 555 }, "b" : { "x" : 526, "y" : 563 }, "c" : { "x" : 534, "y" : 561 }, "type" : "ARROW", "centre" : { "x" : 534, "y" : 561 } } } ] }, { "id" : 93510, "reactomeId" : 10704718, "displayName" : "dgat2l6", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 473, "y" : 506 }, "minX" : 448, "maxX" : 552, "minY" : 487, "maxY" : 519, "prop" : { "x" : 448, "y" : 493, "width" : 51, "height" : 26 }, "textPosition" : { "x" : 449, "y" : 489 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 499, "y" : 493 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 499, "y" : 493 } } }, "connectors" : [ { "edgeId" : 93505, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 502, "y" : 506 }, "to" : { "x" : 544, "y" : 507 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 548, "y" : 508 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 548, "y" : 508 } } } ] }, { "id" : 93513, "reactomeId" : 29356, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1006, "y" : 919 }, "minX" : 985, "maxX" : 1043, "minY" : 887, "maxY" : 934, "prop" : { "x" : 985, "y" : 904, "width" : 43, "height" : 30 }, "textPosition" : { "x" : 989, "y" : 908 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1023, "y" : 909 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1023, "y" : 909 } } }, "connectors" : [ { "edgeId" : 93511, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1023, "y" : 901 }, "to" : { "x" : 1043, "y" : 887 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 93512, "reactomeId" : 5693754, "displayName" : "AEA", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1064, "y" : 946 }, "minX" : 1043, "maxX" : 1085, "minY" : 887, "maxY" : 961, "prop" : { "x" : 1044, "y" : 931, "width" : 40, "height" : 30 }, "textPosition" : { "x" : 1048, "y" : 935 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1079, "y" : 936 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1079, "y" : 936 } } }, "connectors" : [ { "edgeId" : 93511, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1058, "y" : 928 }, "to" : { "x" : 1043, "y" : 887 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 93515, "reactomeId" : 10704057, "displayName" : "FAAH", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 974, "y" : 860 }, "minX" : 954, "maxX" : 1034, "minY" : 843, "maxY" : 871, "prop" : { "x" : 954, "y" : 849, "width" : 40, "height" : 22 }, "textPosition" : { "x" : 954, "y" : 849 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 994, "y" : 849 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 994, "y" : 849 } } }, "connectors" : [ { "edgeId" : 93511, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 997, "y" : 860 }, "to" : { "x" : 1026, "y" : 860 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1030, "y" : 860 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1030, "y" : 860 } } } ] }, { "id" : 93514, "reactomeId" : 1498751, "displayName" : "ETA", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1145, "y" : 869 }, "minX" : 1099, "maxX" : 1166, "minY" : 844, "maxY" : 884, "prop" : { "x" : 1125, "y" : 854, "width" : 40, "height" : 30 }, "textPosition" : { "x" : 1129, "y" : 858 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1160, "y" : 859 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1160, "y" : 859 } } }, "connectors" : [ { "edgeId" : 93511, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1122, "y" : 858 }, "to" : { "x" : 1099, "y" : 844 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1114, "y" : 858 }, "b" : { "x" : 1122, "y" : 858 }, "c" : { "x" : 1118, "y" : 851 }, "type" : "ARROW", "centre" : { "x" : 1118, "y" : 851 } } } ] }, { "id" : 93517, "reactomeId" : 5693752, "displayName" : "AEA", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 544, "y" : 1361 }, "minX" : 524, "maxX" : 585, "minY" : 1345, "maxY" : 1383, "prop" : { "x" : 524, "y" : 1346, "width" : 40, "height" : 30 }, "textPosition" : { "x" : 528, "y" : 1350 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 559, "y" : 1351 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 559, "y" : 1351 } } }, "connectors" : [ { "edgeId" : 93516, "type" : "INPUT", "segments" : [ { "from" : { "x" : 567, "y" : 1371 }, "to" : { "x" : 585, "y" : 1383 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 93519, "reactomeId" : 5693736, "displayName" : "ETA", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 690, "y" : 1350 }, "minX" : 649, "maxX" : 711, "minY" : 1334, "maxY" : 1383, "prop" : { "x" : 670, "y" : 1335, "width" : 40, "height" : 30 }, "textPosition" : { "x" : 674, "y" : 1339 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 705, "y" : 1340 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 705, "y" : 1340 } } }, "connectors" : [ { "edgeId" : 93516, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 671, "y" : 1368 }, "to" : { "x" : 649, "y" : 1383 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 668, "y" : 1375 }, "b" : { "x" : 671, "y" : 1368 }, "c" : { "x" : 663, "y" : 1369 }, "type" : "ARROW", "centre" : { "x" : 663, "y" : 1369 } } } ] }, { "id" : 93518, "reactomeId" : 5693747, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 551, "y" : 1416 }, "minX" : 530, "maxX" : 585, "minY" : 1383, "maxY" : 1431, "prop" : { "x" : 530, "y" : 1401, "width" : 43, "height" : 30 }, "textPosition" : { "x" : 534, "y" : 1405 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 568, "y" : 1406 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 568, "y" : 1406 } } }, "connectors" : [ { "edgeId" : 93516, "type" : "INPUT", "segments" : [ { "from" : { "x" : 566, "y" : 1398 }, "to" : { "x" : 585, "y" : 1383 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 93521, "reactomeId" : 10704064, "displayName" : "faah2", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 619, "y" : 1338 }, "minX" : 595, "maxX" : 649, "minY" : 1321, "maxY" : 1375, "prop" : { "x" : 595, "y" : 1327, "width" : 48, "height" : 22 }, "textPosition" : { "x" : 597, "y" : 1327 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 643, "y" : 1327 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 643, "y" : 1327 } } }, "connectors" : [ { "edgeId" : 93516, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 619, "y" : 1352 }, "to" : { "x" : 619, "y" : 1367 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 619, "y" : 1371 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 619, "y" : 1371 } } } ] }, { "id" : 93520, "reactomeId" : 5693733, "displayName" : "AA", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 696, "y" : 1414 }, "minX" : 649, "maxX" : 714, "minY" : 1383, "maxY" : 1429, "prop" : { "x" : 680, "y" : 1399, "width" : 33, "height" : 30 }, "textPosition" : { "x" : 684, "y" : 1403 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 708, "y" : 1404 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 708, "y" : 1404 } } }, "connectors" : [ { "edgeId" : 93516, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 677, "y" : 1403 }, "to" : { "x" : 649, "y" : 1383 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 669, "y" : 1402 }, "b" : { "x" : 677, "y" : 1403 }, "c" : { "x" : 674, "y" : 1396 }, "type" : "ARROW", "centre" : { "x" : 674, "y" : 1396 } } } ] }, { "id" : 93523, "reactomeId" : 8932801, "displayName" : "5-HETEL", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1730, "y" : 1588 }, "minX" : 1696, "maxX" : 1794, "minY" : 1572, "maxY" : 1603, "prop" : { "x" : 1696, "y" : 1573, "width" : 69, "height" : 30 }, "textPosition" : { "x" : 1701, "y" : 1577 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1760, "y" : 1578 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1760, "y" : 1578 } } }, "connectors" : [ { "edgeId" : 93522, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1768, "y" : 1587 }, "to" : { "x" : 1794, "y" : 1587 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 93525, "reactomeId" : 8932804, "displayName" : "5-HETE", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1945, "y" : 1587 }, "minX" : 1914, "maxX" : 1978, "minY" : 1571, "maxY" : 1602, "prop" : { "x" : 1914, "y" : 1572, "width" : 63, "height" : 30 }, "textPosition" : { "x" : 1919, "y" : 1576 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1972, "y" : 1577 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1972, "y" : 1577 } } }, "connectors" : [ { "edgeId" : 93522, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 93524, "reactomeId" : 109276, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1773, "y" : 1629 }, "minX" : 1752, "maxX" : 1796, "minY" : 1587, "maxY" : 1644, "prop" : { "x" : 1752, "y" : 1614, "width" : 43, "height" : 30 }, "textPosition" : { "x" : 1756, "y" : 1618 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1790, "y" : 1619 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1790, "y" : 1619 } } }, "connectors" : [ { "edgeId" : 93522, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1780, "y" : 1611 }, "to" : { "x" : 1794, "y" : 1587 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 93526, "reactomeId" : 10715577, "displayName" : "PON1,2,3:2xCa2+ dimers", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1834, "y" : 1539 }, "minX" : 1773, "maxX" : 1895, "minY" : 1521, "maxY" : 1579, "prop" : { "x" : 1773, "y" : 1521, "width" : 122, "height" : 36 }, "textPosition" : { "x" : 1773, "y" : 1521 }, "connectors" : [ { "edgeId" : 93522, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1834, "y" : 1563 }, "to" : { "x" : 1834, "y" : 1571 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1835, "y" : 1575 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1835, "y" : 1575 } } } ] }, { "id" : 93529, "reactomeId" : 10716752, "displayName" : "Homologues of ALOXE3", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1381, "y" : 471 }, "minX" : 1351, "maxX" : 1436, "minY" : 460, "maxY" : 482, "prop" : { "x" : 1351, "y" : 460, "width" : 60, "height" : 22 }, "textPosition" : { "x" : 1351, "y" : 447 }, "connectors" : [ { "edgeId" : 93527, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1414, "y" : 471 }, "to" : { "x" : 1428, "y" : 471 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1432, "y" : 471 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1432, "y" : 471 } } } ] }, { "id" : 93528, "reactomeId" : 8942209, "displayName" : "HXA3", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1435, "y" : 366 }, "minX" : 1410, "maxX" : 1462, "minY" : 350, "maxY" : 381, "prop" : { "x" : 1410, "y" : 351, "width" : 51, "height" : 30 }, "textPosition" : { "x" : 1415, "y" : 355 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1456, "y" : 356 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1456, "y" : 356 } } }, "connectors" : [ { "edgeId" : 93527, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 93531, "reactomeId" : 9707237, "displayName" : "ALOX5 inhibitors", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySetDrug", "position" : { "x" : 1603, "y" : 910 }, "minX" : 1528, "maxX" : 1656, "minY" : 899, "maxY" : 938, "prop" : { "x" : 1551, "y" : 899, "width" : 105, "height" : 23 }, "textPosition" : { "x" : 1570, "y" : 893 }, "bgColor" : { "r" : 184, "g" : 154, "b" : 230 }, "fgColor" : { "r" : 161, "g" : 1, "b" : 2 }, "connectors" : [ { "edgeId" : 93530, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1572, "y" : 928 }, "to" : { "x" : 1528, "y" : 938 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 93532, "reactomeId" : 10723007, "displayName" : "ALOX5:ALOX5 inhibitors", "schemaClass" : "Complex", "renderableClass" : "ComplexDrug", "position" : { "x" : 1529, "y" : 998 }, "minX" : 1483, "maxX" : 1582, "minY" : 973, "maxY" : 1017, "prop" : { "x" : 1483, "y" : 979, "width" : 93, "height" : 38 }, "textPosition" : { "x" : 1483, "y" : 982 }, "bgColor" : { "r" : 184, "g" : 154, "b" : 230 }, "fgColor" : { "r" : 161, "g" : 1, "b" : 2 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1576, "y" : 979 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1576, "y" : 979 } } }, "connectors" : [ { "edgeId" : 93530, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 93535, "reactomeId" : 29356, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1191, "y" : 1378 }, "minX" : 1170, "maxX" : 1235, "minY" : 1356, "maxY" : 1394, "prop" : { "x" : 1170, "y" : 1363, "width" : 43, "height" : 31 }, "textPosition" : { "x" : 1174, "y" : 1368 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1208, "y" : 1368 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1208, "y" : 1368 } } }, "connectors" : [ { "edgeId" : 93533, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1216, "y" : 1367 }, "to" : { "x" : 1235, "y" : 1356 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 93534, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1191, "y" : 1331 }, "minX" : 1171, "maxX" : 1235, "minY" : 1315, "maxY" : 1356, "prop" : { "x" : 1171, "y" : 1316, "width" : 40, "height" : 31 }, "textPosition" : { "x" : 1175, "y" : 1321 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1206, "y" : 1321 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1206, "y" : 1321 } } }, "connectors" : [ { "edgeId" : 93533, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1214, "y" : 1342 }, "to" : { "x" : 1235, "y" : 1356 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 93537, "reactomeId" : 29372, "displayName" : "Pi", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1330, "y" : 1385 }, "minX" : 1259, "maxX" : 1345, "minY" : 1369, "maxY" : 1467, "prop" : { "x" : 1317, "y" : 1370, "width" : 27, "height" : 31 }, "textPosition" : { "x" : 1321, "y" : 1375 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1339, "y" : 1375 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1339, "y" : 1375 } } }, "connectors" : [ { "edgeId" : 93533, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1314, "y" : 1400 }, "to" : { "x" : 1259, "y" : 1467 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1313, "y" : 1408 }, "b" : { "x" : 1314, "y" : 1400 }, "c" : { "x" : 1307, "y" : 1403 }, "type" : "ARROW", "centre" : { "x" : 1307, "y" : 1403 } } } ] }, { "id" : 93536, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1285, "y" : 1378 }, "minX" : 1259, "maxX" : 1307, "minY" : 1362, "maxY" : 1467, "prop" : { "x" : 1265, "y" : 1363, "width" : 41, "height" : 31 }, "textPosition" : { "x" : 1269, "y" : 1368 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1301, "y" : 1368 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1301, "y" : 1368 } } }, "connectors" : [ { "edgeId" : 93533, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1280, "y" : 1397 }, "to" : { "x" : 1259, "y" : 1467 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1282, "y" : 1405 }, "b" : { "x" : 1280, "y" : 1397 }, "c" : { "x" : 1274, "y" : 1402 }, "type" : "ARROW", "centre" : { "x" : 1274, "y" : 1402 } } } ] }, { "id" : 93539, "reactomeId" : 10668003, "displayName" : "abcc1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1160, "y" : 1467 }, "minX" : 1136, "maxX" : 1228, "minY" : 1450, "maxY" : 1479, "prop" : { "x" : 1136, "y" : 1456, "width" : 48, "height" : 23 }, "textPosition" : { "x" : 1137, "y" : 1457 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1184, "y" : 1456 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1184, "y" : 1456 } } }, "connectors" : [ { "edgeId" : 93533, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1187, "y" : 1467 }, "to" : { "x" : 1220, "y" : 1467 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1224, "y" : 1467 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1224, "y" : 1467 } } } ] }, { "id" : 93538, "reactomeId" : 70106, "displayName" : "H+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1342, "y" : 1423 }, "minX" : 1259, "maxX" : 1361, "minY" : 1407, "maxY" : 1467, "prop" : { "x" : 1325, "y" : 1408, "width" : 35, "height" : 30 }, "textPosition" : { "x" : 1329, "y" : 1412 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1355, "y" : 1413 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1355, "y" : 1413 } } }, "connectors" : [ { "edgeId" : 93533, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1322, "y" : 1432 }, "to" : { "x" : 1259, "y" : 1467 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1318, "y" : 1439 }, "b" : { "x" : 1322, "y" : 1432 }, "c" : { "x" : 1314, "y" : 1432 }, "type" : "ARROW", "centre" : { "x" : 1314, "y" : 1432 } } } ], "trivial" : true }, { "id" : 93541, "reactomeId" : 2142662, "displayName" : "8,9-EET", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 964, "y" : 181 }, "minX" : 931, "maxX" : 1073, "minY" : 165, "maxY" : 197, "prop" : { "x" : 931, "y" : 166, "width" : 66, "height" : 31 }, "textPosition" : { "x" : 936, "y" : 171 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 992, "y" : 171 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 992, "y" : 171 } } }, "connectors" : [ { "edgeId" : 93540, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1000, "y" : 181 }, "to" : { "x" : 1073, "y" : 182 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 93542, "reactomeId" : 2142765, "displayName" : "8,9-DHET", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1273, "y" : 185 }, "minX" : 1235, "maxX" : 1313, "minY" : 169, "maxY" : 201, "prop" : { "x" : 1235, "y" : 170, "width" : 77, "height" : 31 }, "textPosition" : { "x" : 1241, "y" : 175 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1307, "y" : 175 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1307, "y" : 175 } } }, "connectors" : [ { "edgeId" : 93540, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 93545, "reactomeId" : 2142783, "displayName" : "14,15-DHET", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1273, "y" : 83 }, "minX" : 1227, "maxX" : 1321, "minY" : 67, "maxY" : 99, "prop" : { "x" : 1227, "y" : 68, "width" : 93, "height" : 31 }, "textPosition" : { "x" : 1233, "y" : 73 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1315, "y" : 73 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1315, "y" : 73 } } }, "connectors" : [ { "edgeId" : 93543, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 93544, "reactomeId" : 2142792, "displayName" : "14,15-EET", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 964, "y" : 77 }, "minX" : 923, "maxX" : 1043, "minY" : 61, "maxY" : 93, "prop" : { "x" : 923, "y" : 62, "width" : 82, "height" : 31 }, "textPosition" : { "x" : 928, "y" : 67 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1000, "y" : 67 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1000, "y" : 67 } } }, "connectors" : [ { "edgeId" : 93543, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1008, "y" : 77 }, "to" : { "x" : 1043, "y" : 78 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 93547, "reactomeId" : 2142835, "displayName" : "11,12-EET", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 964, "y" : 132 }, "minX" : 923, "maxX" : 1060, "minY" : 116, "maxY" : 148, "prop" : { "x" : 923, "y" : 117, "width" : 82, "height" : 31 }, "textPosition" : { "x" : 928, "y" : 122 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1000, "y" : 122 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1000, "y" : 122 } } }, "connectors" : [ { "edgeId" : 93546, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1008, "y" : 132 }, "to" : { "x" : 1060, "y" : 134 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 93548, "reactomeId" : 2142779, "displayName" : "11,12-DHET", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1273, "y" : 140 }, "minX" : 1227, "maxX" : 1321, "minY" : 124, "maxY" : 156, "prop" : { "x" : 1227, "y" : 125, "width" : 93, "height" : 31 }, "textPosition" : { "x" : 1233, "y" : 130 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1315, "y" : 130 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1315, "y" : 130 } } }, "connectors" : [ { "edgeId" : 93546, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 93589, "reactomeId" : 10728728, "displayName" : "Synthesis of Prostaglandins (PG) and Thromboxanes (TX)", "schemaClass" : "Pathway", "renderableClass" : "ProcessNode", "position" : { "x" : 970, "y" : 411 }, "minX" : 889, "maxX" : 1052, "minY" : 371, "maxY" : 452, "prop" : { "x" : 889, "y" : 371, "width" : 163, "height" : 81 }, "textPosition" : { "x" : 898, "y" : 376 }, "connectors" : [ ] }, { "id" : 93407, "reactomeId" : 265281, "displayName" : "LTA4", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1270, "y" : 1076 }, "minX" : 1071, "maxX" : 1385, "minY" : 1060, "maxY" : 1155, "prop" : { "x" : 1243, "y" : 1061, "width" : 54, "height" : 30 }, "textPosition" : { "x" : 1251, "y" : 1065 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1292, "y" : 1066 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1292, "y" : 1066 } } }, "connectors" : [ { "edgeId" : 93406, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1268, "y" : 1094 }, "to" : { "x" : 1267, "y" : 1115 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 93411, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1300, "y" : 1075 }, "to" : { "x" : 1385, "y" : 1075 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1307, "y" : 1071 }, "b" : { "x" : 1300, "y" : 1075 }, "c" : { "x" : 1307, "y" : 1079 }, "type" : "ARROW", "centre" : { "x" : 1307, "y" : 1079 } } }, { "edgeId" : 93420, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1240, "y" : 1086 }, "to" : { "x" : 1071, "y" : 1155 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 93409, "reactomeId" : 266066, "displayName" : "LTC4", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1266, "y" : 1311 }, "minX" : 1235, "maxX" : 1294, "minY" : 1295, "maxY" : 1356, "prop" : { "x" : 1239, "y" : 1296, "width" : 54, "height" : 30 }, "textPosition" : { "x" : 1247, "y" : 1300 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1288, "y" : 1301 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1288, "y" : 1301 } } }, "connectors" : [ { "edgeId" : 93533, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1255, "y" : 1329 }, "to" : { "x" : 1235, "y" : 1356 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 93406, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 93408, "reactomeId" : 29450, "displayName" : "GSH", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1101, "y" : 1106 }, "minX" : 1032, "maxX" : 1267, "minY" : 1090, "maxY" : 1121, "prop" : { "x" : 1079, "y" : 1091, "width" : 45, "height" : 30 }, "textPosition" : { "x" : 1084, "y" : 1095 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1119, "y" : 1096 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1119, "y" : 1096 } } }, "connectors" : [ { "edgeId" : 93406, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1127, "y" : 1107 }, "to" : { "x" : 1267, "y" : 1115 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 93417, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1076, "y" : 1106 }, "to" : { "x" : 1032, "y" : 1107 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 93410, "reactomeId" : 10667916, "displayName" : "ALOX5:ALOX5AP:LTC4S", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1449, "y" : 877 }, "minX" : 999, "maxX" : 1528, "minY" : 853, "maxY" : 1162, "prop" : { "x" : 1384, "y" : 859, "width" : 130, "height" : 36 }, "textPosition" : { "x" : 1395, "y" : 860 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1514, "y" : 859 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1514, "y" : 859 } } }, "connectors" : [ { "edgeId" : 93530, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1472, "y" : 898 }, "to" : { "x" : 1528, "y" : 938 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 93406, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1437, "y" : 898 }, "to" : { "x" : 1275, "y" : 1154 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1272, "y" : 1158 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1272, "y" : 1158 } } }, { "edgeId" : 93411, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1449, "y" : 898 }, "to" : { "x" : 1450, "y" : 1059 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1450, "y" : 1063 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1450, "y" : 1063 } } }, { "edgeId" : 93414, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1381, "y" : 877 }, "to" : { "x" : 1323, "y" : 878 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1319, "y" : 878 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1319, "y" : 878 } } }, { "edgeId" : 93417, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1426, "y" : 898 }, "to" : { "x" : 1292, "y" : 1004 } }, { "from" : { "x" : 1292, "y" : 1004 }, "to" : { "x" : 1004, "y" : 1004 } }, { "from" : { "x" : 1004, "y" : 1004 }, "to" : { "x" : 999, "y" : 1133 } }, { "from" : { "x" : 999, "y" : 1133 }, "to" : { "x" : 1016, "y" : 1133 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1020, "y" : 1133 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1020, "y" : 1133 } } } ] }, { "id" : 93413, "reactomeId" : 29356, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1347, "y" : 1111 }, "minX" : 1325, "maxX" : 1385, "minY" : 1075, "maxY" : 1126, "prop" : { "x" : 1325, "y" : 1096, "width" : 45, "height" : 30 }, "textPosition" : { "x" : 1330, "y" : 1100 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1365, "y" : 1101 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1365, "y" : 1101 } } }, "connectors" : [ { "edgeId" : 93411, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1362, "y" : 1093 }, "to" : { "x" : 1385, "y" : 1075 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1365, "y" : 1086 }, "b" : { "x" : 1362, "y" : 1093 }, "c" : { "x" : 1370, "y" : 1092 }, "type" : "ARROW", "centre" : { "x" : 1370, "y" : 1092 } } } ], "trivial" : true }, { "id" : 93412, "reactomeId" : 266010, "displayName" : "5S-HpETE", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1450, "y" : 1132 }, "minX" : 1404, "maxX" : 1497, "minY" : 1116, "maxY" : 1147, "prop" : { "x" : 1404, "y" : 1117, "width" : 92, "height" : 30 }, "textPosition" : { "x" : 1416, "y" : 1121 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1491, "y" : 1122 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1491, "y" : 1122 } } }, "connectors" : [ { "edgeId" : 93411, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 93414, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 93415, "reactomeId" : 29368, "displayName" : "O2", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1329, "y" : 815 }, "minX" : 1308, "maxX" : 1348, "minY" : 799, "maxY" : 842, "prop" : { "x" : 1312, "y" : 800, "width" : 35, "height" : 30 }, "textPosition" : { "x" : 1317, "y" : 804 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1342, "y" : 805 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1342, "y" : 805 } } }, "connectors" : [ { "edgeId" : 93414, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1317, "y" : 833 }, "to" : { "x" : 1308, "y" : 842 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 93416, "reactomeId" : 29768, "displayName" : "AA", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1231, "y" : 800 }, "minX" : 1026, "maxX" : 1402, "minY" : 593, "maxY" : 844, "prop" : { "x" : 1212, "y" : 784, "width" : 38, "height" : 32 }, "textPosition" : { "x" : 1219, "y" : 789 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1245, "y" : 789 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1245, "y" : 789 } } }, "connectors" : [ { "edgeId" : 93511, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1209, "y" : 806 }, "to" : { "x" : 1099, "y" : 844 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1204, "y" : 812 }, "b" : { "x" : 1209, "y" : 806 }, "c" : { "x" : 1201, "y" : 804 }, "type" : "ARROW", "centre" : { "x" : 1201, "y" : 804 } } }, { "edgeId" : 93464, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1219, "y" : 781 }, "to" : { "x" : 1077, "y" : 593 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 93472, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1230, "y" : 781 }, "to" : { "x" : 1229, "y" : 716 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 93414, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1253, "y" : 810 }, "to" : { "x" : 1308, "y" : 842 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 93486, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1253, "y" : 789 }, "to" : { "x" : 1402, "y" : 702 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 93499, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1209, "y" : 792 }, "to" : { "x" : 1026, "y" : 719 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1201, "y" : 793 }, "b" : { "x" : 1209, "y" : 792 }, "c" : { "x" : 1204, "y" : 786 }, "type" : "ARROW", "centre" : { "x" : 1204, "y" : 786 } } } ] }, { "id" : 93419, "reactomeId" : 2142726, "displayName" : "EXC4", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1048, "y" : 1187 }, "minX" : 1021, "maxX" : 1076, "minY" : 1171, "maxY" : 1202, "prop" : { "x" : 1021, "y" : 1172, "width" : 54, "height" : 30 }, "textPosition" : { "x" : 1028, "y" : 1176 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1070, "y" : 1177 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1070, "y" : 1177 } } }, "connectors" : [ { "edgeId" : 93417, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 93418, "reactomeId" : 2142772, "displayName" : "EXA4", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1033, "y" : 1077 }, "minX" : 1006, "maxX" : 1061, "minY" : 1061, "maxY" : 1107, "prop" : { "x" : 1006, "y" : 1062, "width" : 54, "height" : 30 }, "textPosition" : { "x" : 1013, "y" : 1066 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1055, "y" : 1067 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1055, "y" : 1067 } } }, "connectors" : [ { "edgeId" : 93417, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1032, "y" : 1095 }, "to" : { "x" : 1032, "y" : 1107 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 93421, "reactomeId" : 29356, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1212, "y" : 1200 }, "minX" : 1071, "maxX" : 1236, "minY" : 1155, "maxY" : 1215, "prop" : { "x" : 1190, "y" : 1185, "width" : 45, "height" : 30 }, "textPosition" : { "x" : 1195, "y" : 1189 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1230, "y" : 1190 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1230, "y" : 1190 } } }, "connectors" : [ { "edgeId" : 93420, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1187, "y" : 1192 }, "to" : { "x" : 1071, "y" : 1155 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 93423, "reactomeId" : 10668012, "displayName" : "LTA4H:Zn2+", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 963, "y" : 1207 }, "minX" : 914, "maxX" : 1018, "minY" : 1163, "maxY" : 1218, "prop" : { "x" : 914, "y" : 1196, "width" : 98, "height" : 22 }, "textPosition" : { "x" : 920, "y" : 1197 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1012, "y" : 1196 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1012, "y" : 1196 } } }, "connectors" : [ { "edgeId" : 93420, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 963, "y" : 1193 }, "to" : { "x" : 964, "y" : 1171 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 964, "y" : 1167 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 964, "y" : 1167 } } } ] }, { "id" : 93422, "reactomeId" : 266056, "displayName" : "LTB4", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 900, "y" : 1157 }, "minX" : 833, "maxX" : 928, "minY" : 1141, "maxY" : 1172, "prop" : { "x" : 873, "y" : 1142, "width" : 54, "height" : 30 }, "textPosition" : { "x" : 881, "y" : 1146 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 922, "y" : 1147 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 922, "y" : 1147 } } }, "connectors" : [ { "edgeId" : 93420, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 93424, "type" : "INPUT", "segments" : [ { "from" : { "x" : 870, "y" : 1157 }, "to" : { "x" : 833, "y" : 1157 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 93425, "reactomeId" : 70106, "displayName" : "H+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 802, "y" : 1196 }, "minX" : 785, "maxX" : 833, "minY" : 1157, "maxY" : 1211, "prop" : { "x" : 785, "y" : 1181, "width" : 35, "height" : 30 }, "textPosition" : { "x" : 789, "y" : 1185 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 815, "y" : 1186 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 815, "y" : 1186 } } }, "connectors" : [ { "edgeId" : 93424, "type" : "INPUT", "segments" : [ { "from" : { "x" : 813, "y" : 1178 }, "to" : { "x" : 833, "y" : 1157 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 93427, "reactomeId" : 29368, "displayName" : "O2", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 867, "y" : 1196 }, "minX" : 833, "maxX" : 886, "minY" : 1157, "maxY" : 1211, "prop" : { "x" : 850, "y" : 1181, "width" : 35, "height" : 30 }, "textPosition" : { "x" : 855, "y" : 1185 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 880, "y" : 1186 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 880, "y" : 1186 } } }, "connectors" : [ { "edgeId" : 93424, "type" : "INPUT", "segments" : [ { "from" : { "x" : 853, "y" : 1178 }, "to" : { "x" : 833, "y" : 1157 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 93426, "reactomeId" : 29364, "displayName" : "NADPH", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 837, "y" : 1235 }, "minX" : 806, "maxX" : 870, "minY" : 1157, "maxY" : 1250, "prop" : { "x" : 806, "y" : 1220, "width" : 63, "height" : 30 }, "textPosition" : { "x" : 812, "y" : 1224 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 864, "y" : 1225 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 864, "y" : 1225 } } }, "connectors" : [ { "edgeId" : 93424, "type" : "INPUT", "segments" : [ { "from" : { "x" : 836, "y" : 1217 }, "to" : { "x" : 833, "y" : 1157 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 93429, "reactomeId" : 29356, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 721, "y" : 1195 }, "minX" : 699, "maxX" : 755, "minY" : 1156, "maxY" : 1210, "prop" : { "x" : 699, "y" : 1180, "width" : 45, "height" : 30 }, "textPosition" : { "x" : 704, "y" : 1184 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 739, "y" : 1185 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 739, "y" : 1185 } } }, "connectors" : [ { "edgeId" : 93424, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 734, "y" : 1177 }, "to" : { "x" : 755, "y" : 1156 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 736, "y" : 1169 }, "b" : { "x" : 734, "y" : 1177 }, "c" : { "x" : 742, "y" : 1175 }, "type" : "ARROW", "centre" : { "x" : 742, "y" : 1175 } } } ], "trivial" : true }, { "id" : 93428, "reactomeId" : 2161636, "displayName" : "20OH-LTB4", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 682, "y" : 1157 }, "minX" : 615, "maxX" : 755, "minY" : 1141, "maxY" : 1173, "prop" : { "x" : 638, "y" : 1142, "width" : 89, "height" : 31 }, "textPosition" : { "x" : 645, "y" : 1147 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 722, "y" : 1147 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 722, "y" : 1147 } } }, "connectors" : [ { "edgeId" : 93424, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 730, "y" : 1156 }, "to" : { "x" : 755, "y" : 1156 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 737, "y" : 1152 }, "b" : { "x" : 730, "y" : 1156 }, "c" : { "x" : 737, "y" : 1160 }, "type" : "ARROW", "centre" : { "x" : 737, "y" : 1160 } } }, { "edgeId" : 93432, "type" : "INPUT", "segments" : [ { "from" : { "x" : 635, "y" : 1155 }, "to" : { "x" : 615, "y" : 1154 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 93431, "reactomeId" : 10667287, "displayName" : "Cytochrome P450 (CYP4F2/4F3 based)", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 591, "y" : 1106 }, "minX" : 339, "maxX" : 799, "minY" : 1087, "maxY" : 1148, "prop" : { "x" : 507, "y" : 1087, "width" : 169, "height" : 39 }, "textPosition" : { "x" : 524, "y" : 1089 }, "connectors" : [ { "edgeId" : 93424, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 682, "y" : 1113 }, "to" : { "x" : 794, "y" : 1125 } }, { "from" : { "x" : 794, "y" : 1125 }, "to" : { "x" : 794, "y" : 1140 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 795, "y" : 1144 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 795, "y" : 1144 } } }, { "edgeId" : 93432, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 591, "y" : 1132 }, "to" : { "x" : 591, "y" : 1137 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 591, "y" : 1141 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 591, "y" : 1141 } } }, { "edgeId" : 93439, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 501, "y" : 1112 }, "to" : { "x" : 351, "y" : 1125 } }, { "from" : { "x" : 351, "y" : 1125 }, "to" : { "x" : 344, "y" : 1138 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 343, "y" : 1141 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 343, "y" : 1141 } } } ] }, { "id" : 93430, "reactomeId" : 29366, "displayName" : "NADP+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 757, "y" : 1236 }, "minX" : 726, "maxX" : 790, "minY" : 1156, "maxY" : 1251, "prop" : { "x" : 726, "y" : 1221, "width" : 63, "height" : 30 }, "textPosition" : { "x" : 731, "y" : 1225 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 784, "y" : 1226 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 784, "y" : 1226 } } }, "connectors" : [ { "edgeId" : 93424, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 756, "y" : 1218 }, "to" : { "x" : 755, "y" : 1156 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 752, "y" : 1211 }, "b" : { "x" : 756, "y" : 1218 }, "c" : { "x" : 760, "y" : 1211 }, "type" : "ARROW", "centre" : { "x" : 760, "y" : 1211 } } } ] }, { "id" : 93433, "reactomeId" : 70106, "displayName" : "H+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 592, "y" : 1192 }, "minX" : 575, "maxX" : 615, "minY" : 1154, "maxY" : 1207, "prop" : { "x" : 575, "y" : 1177, "width" : 35, "height" : 30 }, "textPosition" : { "x" : 579, "y" : 1181 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 605, "y" : 1182 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 605, "y" : 1182 } } }, "connectors" : [ { "edgeId" : 93432, "type" : "INPUT", "segments" : [ { "from" : { "x" : 601, "y" : 1174 }, "to" : { "x" : 615, "y" : 1154 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 93435, "reactomeId" : 29368, "displayName" : "O2", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 659, "y" : 1196 }, "minX" : 615, "maxX" : 678, "minY" : 1154, "maxY" : 1211, "prop" : { "x" : 642, "y" : 1181, "width" : 35, "height" : 30 }, "textPosition" : { "x" : 647, "y" : 1185 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 672, "y" : 1186 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 672, "y" : 1186 } } }, "connectors" : [ { "edgeId" : 93432, "type" : "INPUT", "segments" : [ { "from" : { "x" : 643, "y" : 1178 }, "to" : { "x" : 615, "y" : 1154 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 93434, "reactomeId" : 29364, "displayName" : "NADPH", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 631, "y" : 1234 }, "minX" : 600, "maxX" : 664, "minY" : 1154, "maxY" : 1249, "prop" : { "x" : 600, "y" : 1219, "width" : 63, "height" : 30 }, "textPosition" : { "x" : 606, "y" : 1223 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 658, "y" : 1224 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 658, "y" : 1224 } } }, "connectors" : [ { "edgeId" : 93432, "type" : "INPUT", "segments" : [ { "from" : { "x" : 628, "y" : 1216 }, "to" : { "x" : 615, "y" : 1154 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 93437, "reactomeId" : 29356, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 547, "y" : 1233 }, "minX" : 525, "maxX" : 571, "minY" : 1153, "maxY" : 1248, "prop" : { "x" : 525, "y" : 1218, "width" : 45, "height" : 30 }, "textPosition" : { "x" : 530, "y" : 1222 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 565, "y" : 1223 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 565, "y" : 1223 } } }, "connectors" : [ { "edgeId" : 93432, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 547, "y" : 1215 }, "to" : { "x" : 548, "y" : 1153 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 541, "y" : 1178 }, "b" : { "x" : 553, "y" : 1190 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 547, "y" : 1184 } } }, "endShape" : { "a" : { "x" : 543, "y" : 1208 }, "b" : { "x" : 547, "y" : 1215 }, "c" : { "x" : 551, "y" : 1208 }, "type" : "ARROW", "centre" : { "x" : 551, "y" : 1208 } } } ], "trivial" : true }, { "id" : 93436, "reactomeId" : 2142740, "displayName" : "20cho-LTB4", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 458, "y" : 1153 }, "minX" : 365, "maxX" : 548, "minY" : 1137, "maxY" : 1168, "prop" : { "x" : 408, "y" : 1138, "width" : 101, "height" : 30 }, "textPosition" : { "x" : 418, "y" : 1142 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 504, "y" : 1143 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 504, "y" : 1143 } } }, "connectors" : [ { "edgeId" : 93432, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 512, "y" : 1153 }, "to" : { "x" : 548, "y" : 1153 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 519, "y" : 1149 }, "b" : { "x" : 512, "y" : 1153 }, "c" : { "x" : 519, "y" : 1157 }, "type" : "ARROW", "centre" : { "x" : 519, "y" : 1157 } } }, { "edgeId" : 93439, "type" : "INPUT", "segments" : [ { "from" : { "x" : 405, "y" : 1152 }, "to" : { "x" : 365, "y" : 1152 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 93438, "reactomeId" : 29366, "displayName" : "NADP+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 508, "y" : 1197 }, "minX" : 482, "maxX" : 548, "minY" : 1153, "maxY" : 1213, "prop" : { "x" : 482, "y" : 1181, "width" : 53, "height" : 32 }, "textPosition" : { "x" : 482, "y" : 1186 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 530, "y" : 1186 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 530, "y" : 1186 } } }, "connectors" : [ { "edgeId" : 93432, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 522, "y" : 1178 }, "to" : { "x" : 548, "y" : 1153 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 524, "y" : 1170 }, "b" : { "x" : 522, "y" : 1178 }, "c" : { "x" : 530, "y" : 1176 }, "type" : "ARROW", "centre" : { "x" : 530, "y" : 1176 } } } ] } ], "edges" : [ { "id" : 93505, "reactomeId" : 10704721, "displayName" : "AWAT1 transfers acyl group from acyl-CoA to ARACOH, forming wax esters", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 560, "y" : 508 }, "minX" : 554, "maxX" : 566, "minY" : 482, "maxY" : 533, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 560, "y" : 482 }, "to" : { "x" : 560, "y" : 508 } }, { "from" : { "x" : 560, "y" : 508 }, "to" : { "x" : 560, "y" : 533 } } ], "reactionShape" : { "a" : { "x" : 554, "y" : 502 }, "b" : { "x" : 566, "y" : 514 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 560, "y" : 508 } }, "inputs" : [ { "id" : 93506, "points" : [ { "x" : 535, "y" : 453 } ] }, { "id" : 93507, "points" : [ { "x" : 590, "y" : 454 } ] } ], "outputs" : [ { "id" : 93508, "points" : [ { "x" : 526, "y" : 563 } ] }, { "id" : 93509, "points" : [ { "x" : 584, "y" : 561 } ] } ], "catalysts" : [ { "id" : 93510, "points" : [ { "x" : 502, "y" : 506 } ] } ] }, { "id" : 93511, "reactomeId" : 10704060, "displayName" : "FAAH hydrolyses AEA to AA and ETA", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1042, "y" : 860 }, "minX" : 1036, "maxX" : 1099, "minY" : 844, "maxY" : 887, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1043, "y" : 887 }, "to" : { "x" : 1042, "y" : 860 } }, { "from" : { "x" : 1042, "y" : 860 }, "to" : { "x" : 1099, "y" : 844 } } ], "reactionShape" : { "a" : { "x" : 1036, "y" : 854 }, "b" : { "x" : 1048, "y" : 866 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1042, "y" : 860 } }, "inputs" : [ { "id" : 93512, "points" : [ { "x" : 1058, "y" : 928 } ] }, { "id" : 93513, "points" : [ { "x" : 1023, "y" : 901 } ] } ], "outputs" : [ { "id" : 93514, "points" : [ { "x" : 1122, "y" : 858 } ] }, { "id" : 93416, "points" : [ { "x" : 1209, "y" : 806 } ] } ], "catalysts" : [ { "id" : 93515, "points" : [ { "x" : 997, "y" : 860 } ] } ] }, { "id" : 93446, "reactomeId" : 10667994, "displayName" : "GGT1, 5 dimers hydrolyse LTC4 to LTD4", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1344, "y" : 1529 }, "minX" : 1321, "maxX" : 1376, "minY" : 1523, "maxY" : 1535, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1321, "y" : 1529 }, "to" : { "x" : 1344, "y" : 1529 } }, { "from" : { "x" : 1344, "y" : 1529 }, "to" : { "x" : 1376, "y" : 1529 } } ], "reactionShape" : { "a" : { "x" : 1338, "y" : 1523 }, "b" : { "x" : 1350, "y" : 1535 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1344, "y" : 1529 } }, "inputs" : [ { "id" : 93447, "points" : [ { "x" : 1290, "y" : 1528 } ] }, { "id" : 93448, "points" : [ { "x" : 1294, "y" : 1554 } ] } ], "outputs" : [ { "id" : 93449, "points" : [ { "x" : 1389, "y" : 1549 } ] }, { "id" : 93450, "points" : [ { "x" : 1405, "y" : 1530 } ] } ], "catalysts" : [ { "id" : 93451, "points" : [ { "x" : 1343, "y" : 1499 } ] } ] }, { "id" : 93452, "reactomeId" : 10689071, "displayName" : "Arachidonate is hydroxylated to 19-HETE by CYP(2)", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 593, "y" : 931 }, "minX" : 587, "maxX" : 599, "minY" : 897, "maxY" : 970, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 593, "y" : 897 }, "to" : { "x" : 593, "y" : 931 } }, { "from" : { "x" : 593, "y" : 931 }, "to" : { "x" : 592, "y" : 970 } } ], "reactionShape" : { "a" : { "x" : 587, "y" : 925 }, "b" : { "x" : 599, "y" : 937 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 593, "y" : 931 } }, "inputs" : [ { "id" : 93453, "points" : [ { "x" : 540, "y" : 795 } ] }, { "id" : 93454, "points" : [ { "x" : 688, "y" : 567 } ] }, { "id" : 93455, "points" : [ { "x" : 527, "y" : 842 } ] }, { "id" : 93456, "points" : [ { "x" : 586, "y" : 753 } ] } ], "outputs" : [ { "id" : 93457, "points" : [ { "x" : 624, "y" : 1027 } ] }, { "id" : 93458, "points" : [ { "x" : 721, "y" : 991 } ] }, { "id" : 93459, "points" : [ { "x" : 561, "y" : 1024 } ] } ], "catalysts" : [ { "id" : 93460, "points" : [ { "x" : 495, "y" : 923 } ] } ] }, { "id" : 93516, "reactomeId" : 10704067, "displayName" : "FAAH2 hydrolyses AEA to AA and ETA", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 619, "y" : 1383 }, "minX" : 585, "maxX" : 649, "minY" : 1377, "maxY" : 1389, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 585, "y" : 1383 }, "to" : { "x" : 619, "y" : 1383 } }, { "from" : { "x" : 619, "y" : 1383 }, "to" : { "x" : 649, "y" : 1383 } } ], "reactionShape" : { "a" : { "x" : 613, "y" : 1377 }, "b" : { "x" : 625, "y" : 1389 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 619, "y" : 1383 } }, "inputs" : [ { "id" : 93517, "points" : [ { "x" : 567, "y" : 1371 } ] }, { "id" : 93518, "points" : [ { "x" : 566, "y" : 1398 } ] } ], "outputs" : [ { "id" : 93519, "points" : [ { "x" : 671, "y" : 1368 } ] }, { "id" : 93520, "points" : [ { "x" : 677, "y" : 1403 } ] } ], "catalysts" : [ { "id" : 93521, "points" : [ { "x" : 619, "y" : 1352 } ] } ] }, { "id" : 93522, "reactomeId" : 10715580, "displayName" : "PON1,2,3:Ca2+ dimers hydrolyse 5-HETEL to 5-HETE", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1835, "y" : 1587 }, "minX" : 1794, "maxX" : 1911, "minY" : 1581, "maxY" : 1593, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1794, "y" : 1587 }, "to" : { "x" : 1835, "y" : 1587 } }, { "from" : { "x" : 1835, "y" : 1587 }, "to" : { "x" : 1911, "y" : 1587 } } ], "endShape" : { "a" : { "x" : 1904, "y" : 1591 }, "b" : { "x" : 1911, "y" : 1587 }, "c" : { "x" : 1904, "y" : 1583 }, "type" : "ARROW", "centre" : { "x" : 1904, "y" : 1583 } }, "reactionShape" : { "a" : { "x" : 1829, "y" : 1581 }, "b" : { "x" : 1841, "y" : 1593 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1835, "y" : 1587 } }, "inputs" : [ { "id" : 93523, "points" : [ { "x" : 1768, "y" : 1587 } ] }, { "id" : 93524, "points" : [ { "x" : 1780, "y" : 1611 } ] } ], "outputs" : [ { "id" : 93525 } ], "catalysts" : [ { "id" : 93526, "points" : [ { "x" : 1834, "y" : 1563 } ] } ] }, { "id" : 93461, "reactomeId" : 10689081, "displayName" : "Arachidonate is hydroxylated to 20-HETE by CYP(3)", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 566, "y" : 944 }, "minX" : 560, "maxX" : 572, "minY" : 909, "maxY" : 982, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 566, "y" : 909 }, "to" : { "x" : 566, "y" : 944 } }, { "from" : { "x" : 566, "y" : 944 }, "to" : { "x" : 565, "y" : 982 } } ], "reactionShape" : { "a" : { "x" : 560, "y" : 938 }, "b" : { "x" : 572, "y" : 950 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 566, "y" : 944 } }, "inputs" : [ { "id" : 93453, "points" : [ { "x" : 536, "y" : 795 } ] }, { "id" : 93456, "points" : [ { "x" : 584, "y" : 753 } ] }, { "id" : 93454, "points" : [ { "x" : 687, "y" : 567 } ] }, { "id" : 93455, "points" : [ { "x" : 519, "y" : 842 } ] } ], "outputs" : [ { "id" : 93457, "points" : [ { "x" : 616, "y" : 1027 } ] }, { "id" : 93462, "points" : [ { "x" : 711, "y" : 1022 } ] }, { "id" : 93459, "points" : [ { "x" : 556, "y" : 1024 } ] } ], "catalysts" : [ { "id" : 93463, "points" : [ { "x" : 487, "y" : 970 } ] } ] }, { "id" : 93527, "reactomeId" : 10716755, "displayName" : "ALOXE3 isomerises 12R-HpETE to HXA3", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1444, "y" : 471 }, "minX" : 1436, "maxX" : 1490, "minY" : 384, "maxY" : 558, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1490, "y" : 558 }, "to" : { "x" : 1444, "y" : 471 } }, { "from" : { "x" : 1444, "y" : 471 }, "to" : { "x" : 1436, "y" : 384 } } ], "endShape" : { "a" : { "x" : 1441, "y" : 391 }, "b" : { "x" : 1436, "y" : 384 }, "c" : { "x" : 1433, "y" : 391 }, "type" : "ARROW", "centre" : { "x" : 1433, "y" : 391 } }, "reactionShape" : { "a" : { "x" : 1438, "y" : 465 }, "b" : { "x" : 1450, "y" : 477 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1444, "y" : 471 } }, "inputs" : [ { "id" : 93488 } ], "outputs" : [ { "id" : 93528 } ], "catalysts" : [ { "id" : 93529, "points" : [ { "x" : 1414, "y" : 471 } ] } ] }, { "id" : 93464, "reactomeId" : 10689112, "displayName" : "Arachidonate is oxidised to 15R-HETE by Acetyl-PTGS2", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1077, "y" : 572 }, "minX" : 1071, "maxX" : 1083, "minY" : 551, "maxY" : 593, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1077, "y" : 593 }, "to" : { "x" : 1077, "y" : 572 } }, { "from" : { "x" : 1077, "y" : 572 }, "to" : { "x" : 1077, "y" : 551 } } ], "reactionShape" : { "a" : { "x" : 1071, "y" : 566 }, "b" : { "x" : 1083, "y" : 578 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1077, "y" : 572 } }, "inputs" : [ { "id" : 93416, "points" : [ { "x" : 1219, "y" : 781 } ] }, { "id" : 93465, "points" : [ { "x" : 1111, "y" : 586 } ] }, { "id" : 93466, "points" : [ { "x" : 1053, "y" : 596 } ] }, { "id" : 93467, "points" : [ { "x" : 1143, "y" : 628 } ] } ], "outputs" : [ { "id" : 93468, "points" : [ { "x" : 1058, "y" : 539 } ] }, { "id" : 93469, "points" : [ { "x" : 1076, "y" : 510 } ] }, { "id" : 93470, "points" : [ { "x" : 1098, "y" : 542 } ] } ], "catalysts" : [ { "id" : 93471, "points" : [ { "x" : 982, "y" : 519 }, { "x" : 1021, "y" : 572 } ] } ] }, { "id" : 93530, "reactomeId" : 10723009, "displayName" : "ALOX5 binds ALOX5 inhibitors", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1529, "y" : 937 }, "minX" : 1523, "maxX" : 1535, "minY" : 931, "maxY" : 976, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1528, "y" : 938 }, "to" : { "x" : 1529, "y" : 937 } }, { "from" : { "x" : 1529, "y" : 937 }, "to" : { "x" : 1529, "y" : 976 } } ], "endShape" : { "a" : { "x" : 1525, "y" : 969 }, "b" : { "x" : 1529, "y" : 976 }, "c" : { "x" : 1533, "y" : 969 }, "type" : "ARROW", "centre" : { "x" : 1533, "y" : 969 } }, "reactionShape" : { "c" : { "x" : 1529, "y" : 937 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1529, "y" : 937 } }, "inputs" : [ { "id" : 93531, "points" : [ { "x" : 1572, "y" : 928 } ] }, { "id" : 93410, "points" : [ { "x" : 1472, "y" : 898 } ] } ], "outputs" : [ { "id" : 93532 } ] }, { "id" : 93533, "reactomeId" : 10668006, "displayName" : "LTC4 is exported from the cytosol by ABCC1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1236, "y" : 1467 }, "minX" : 1230, "maxX" : 1259, "minY" : 1356, "maxY" : 1473, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1235, "y" : 1356 }, "to" : { "x" : 1236, "y" : 1467 } }, { "from" : { "x" : 1236, "y" : 1467 }, "to" : { "x" : 1259, "y" : 1467 } } ], "reactionShape" : { "a" : { "x" : 1230, "y" : 1461 }, "b" : { "x" : 1242, "y" : 1473 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1236, "y" : 1467 } }, "inputs" : [ { "id" : 93534, "points" : [ { "x" : 1214, "y" : 1342 } ] }, { "id" : 93535, "points" : [ { "x" : 1216, "y" : 1367 } ] }, { "id" : 93409, "points" : [ { "x" : 1255, "y" : 1329 } ] } ], "outputs" : [ { "id" : 93447, "points" : [ { "x" : 1259, "y" : 1510 } ] }, { "id" : 93536, "points" : [ { "x" : 1280, "y" : 1397 } ] }, { "id" : 93537, "points" : [ { "x" : 1314, "y" : 1400 } ] }, { "id" : 93538, "points" : [ { "x" : 1322, "y" : 1432 } ] } ], "catalysts" : [ { "id" : 93539, "points" : [ { "x" : 1187, "y" : 1467 } ] } ] }, { "id" : 93406, "reactomeId" : 10667997, "displayName" : "LTA4 is converted to LTC4 by LTC4S", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1266, "y" : 1168 }, "minX" : 1260, "maxX" : 1272, "minY" : 1115, "maxY" : 1293, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1267, "y" : 1115 }, "to" : { "x" : 1266, "y" : 1168 } }, { "from" : { "x" : 1266, "y" : 1168 }, "to" : { "x" : 1266, "y" : 1293 } } ], "endShape" : { "a" : { "x" : 1262, "y" : 1286 }, "b" : { "x" : 1266, "y" : 1293 }, "c" : { "x" : 1270, "y" : 1286 }, "type" : "ARROW", "centre" : { "x" : 1270, "y" : 1286 } }, "reactionShape" : { "a" : { "x" : 1260, "y" : 1162 }, "b" : { "x" : 1272, "y" : 1174 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1266, "y" : 1168 } }, "inputs" : [ { "id" : 93407, "points" : [ { "x" : 1268, "y" : 1094 } ] }, { "id" : 93408, "points" : [ { "x" : 1127, "y" : 1107 } ] } ], "outputs" : [ { "id" : 93409 } ], "catalysts" : [ { "id" : 93410, "points" : [ { "x" : 1437, "y" : 898 } ] } ] }, { "id" : 93472, "reactomeId" : 10689135, "displayName" : "Arachidonate is oxidised to 15S-HpETE by ALOX15/15B", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1230, "y" : 680 }, "minX" : 1224, "maxX" : 1253, "minY" : 624, "maxY" : 716, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1229, "y" : 716 }, "to" : { "x" : 1230, "y" : 680 } }, { "from" : { "x" : 1230, "y" : 680 }, "to" : { "x" : 1253, "y" : 624 } } ], "endShape" : { "a" : { "x" : 1254, "y" : 632 }, "b" : { "x" : 1253, "y" : 624 }, "c" : { "x" : 1247, "y" : 629 }, "type" : "ARROW", "centre" : { "x" : 1247, "y" : 629 } }, "reactionShape" : { "a" : { "x" : 1224, "y" : 674 }, "b" : { "x" : 1236, "y" : 686 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1230, "y" : 680 } }, "inputs" : [ { "id" : 93416, "points" : [ { "x" : 1230, "y" : 781 } ] }, { "id" : 93467, "points" : [ { "x" : 1175, "y" : 655 } ] } ], "outputs" : [ { "id" : 93473 } ], "catalysts" : [ { "id" : 93474, "points" : [ { "x" : 1270, "y" : 680 } ] } ] }, { "id" : 93475, "reactomeId" : 10689063, "displayName" : "15S-HpETE is reduced to 15S-HETE by GPX1/2/4", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1258, "y" : 535 }, "minX" : 1252, "maxX" : 1264, "minY" : 501, "maxY" : 562, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1259, "y" : 562 }, "to" : { "x" : 1258, "y" : 535 } }, { "from" : { "x" : 1258, "y" : 535 }, "to" : { "x" : 1257, "y" : 501 } } ], "reactionShape" : { "a" : { "x" : 1252, "y" : 529 }, "b" : { "x" : 1264, "y" : 541 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1258, "y" : 535 } }, "inputs" : [ { "id" : 93473, "points" : [ { "x" : 1259, "y" : 588 } ] }, { "id" : 93476, "points" : [ { "x" : 1223, "y" : 569 } ], "stoichiometry" : 2 } ], "outputs" : [ { "id" : 93477, "points" : [ { "x" : 1289, "y" : 496 } ] }, { "id" : 93478, "points" : [ { "x" : 1257, "y" : 479 } ] }, { "id" : 93479, "points" : [ { "x" : 1218, "y" : 494 } ] } ], "catalysts" : [ { "id" : 93480, "points" : [ { "x" : 1285, "y" : 536 } ] } ] }, { "id" : 93411, "reactomeId" : 10667999, "displayName" : "5S-HpETE is dehydrated to LTA4 by ALOX5", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1450, "y" : 1075 }, "minX" : 1385, "maxX" : 1456, "minY" : 1069, "maxY" : 1114, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1450, "y" : 1114 }, "to" : { "x" : 1450, "y" : 1075 } }, { "from" : { "x" : 1450, "y" : 1075 }, "to" : { "x" : 1385, "y" : 1075 } } ], "reactionShape" : { "a" : { "x" : 1444, "y" : 1069 }, "b" : { "x" : 1456, "y" : 1081 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1450, "y" : 1075 } }, "inputs" : [ { "id" : 93412 } ], "outputs" : [ { "id" : 93413, "points" : [ { "x" : 1362, "y" : 1093 } ] }, { "id" : 93407, "points" : [ { "x" : 1300, "y" : 1075 } ] } ], "catalysts" : [ { "id" : 93410, "points" : [ { "x" : 1449, "y" : 898 } ] } ] }, { "id" : 93540, "reactomeId" : 10726881, "displayName" : "8,9-EET is hydrolysed to 8.9-DHET by EPHX2", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1107, "y" : 183 }, "minX" : 1073, "maxX" : 1232, "minY" : 177, "maxY" : 189, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1073, "y" : 182 }, "to" : { "x" : 1107, "y" : 183 } }, { "from" : { "x" : 1107, "y" : 183 }, "to" : { "x" : 1232, "y" : 184 } } ], "endShape" : { "a" : { "x" : 1225, "y" : 188 }, "b" : { "x" : 1232, "y" : 184 }, "c" : { "x" : 1225, "y" : 180 }, "type" : "ARROW", "centre" : { "x" : 1225, "y" : 180 } }, "reactionShape" : { "a" : { "x" : 1101, "y" : 177 }, "b" : { "x" : 1113, "y" : 189 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1107, "y" : 183 } }, "inputs" : [ { "id" : 93541, "points" : [ { "x" : 1000, "y" : 181 } ] }, { "id" : 93482, "points" : [ { "x" : 1052, "y" : 260 } ] } ], "outputs" : [ { "id" : 93542 } ], "catalysts" : [ { "id" : 93485, "points" : [ { "x" : 1161, "y" : 259 } ] } ] }, { "id" : 93543, "reactomeId" : 10726885, "displayName" : "14,15-EET is hydrolysed to 14,15-DHET by EPHX2", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1104, "y" : 80 }, "minX" : 1043, "maxX" : 1224, "minY" : 74, "maxY" : 86, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1043, "y" : 78 }, "to" : { "x" : 1104, "y" : 80 } }, { "from" : { "x" : 1104, "y" : 80 }, "to" : { "x" : 1224, "y" : 82 } } ], "endShape" : { "a" : { "x" : 1217, "y" : 86 }, "b" : { "x" : 1224, "y" : 82 }, "c" : { "x" : 1217, "y" : 78 }, "type" : "ARROW", "centre" : { "x" : 1217, "y" : 78 } }, "reactionShape" : { "a" : { "x" : 1098, "y" : 74 }, "b" : { "x" : 1110, "y" : 86 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1104, "y" : 80 } }, "inputs" : [ { "id" : 93544, "points" : [ { "x" : 1008, "y" : 77 } ] }, { "id" : 93482, "points" : [ { "x" : 1047, "y" : 260 } ] } ], "outputs" : [ { "id" : 93545 } ], "catalysts" : [ { "id" : 93485, "points" : [ { "x" : 1165, "y" : 259 } ] } ] }, { "id" : 93414, "reactomeId" : 10667919, "displayName" : "Arachidonate is oxidised to 5S-HpETE by ALOX5", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1307, "y" : 878 }, "minX" : 1301, "maxX" : 1441, "minY" : 842, "maxY" : 1114, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1308, "y" : 842 }, "to" : { "x" : 1307, "y" : 878 } }, { "from" : { "x" : 1307, "y" : 878 }, "to" : { "x" : 1441, "y" : 1114 } } ], "endShape" : { "a" : { "x" : 1434, "y" : 1110 }, "b" : { "x" : 1441, "y" : 1114 }, "c" : { "x" : 1441, "y" : 1106 }, "type" : "ARROW", "centre" : { "x" : 1441, "y" : 1106 } }, "reactionShape" : { "a" : { "x" : 1301, "y" : 872 }, "b" : { "x" : 1313, "y" : 884 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1307, "y" : 878 } }, "inputs" : [ { "id" : 93415, "points" : [ { "x" : 1317, "y" : 833 } ] }, { "id" : 93416, "points" : [ { "x" : 1253, "y" : 810 } ] } ], "outputs" : [ { "id" : 93412 } ], "catalysts" : [ { "id" : 93410, "points" : [ { "x" : 1381, "y" : 877 } ] } ] }, { "id" : 93481, "reactomeId" : 10689126, "displayName" : "5,6-EET is hydrolysed to 5,6-DHET by EPHX2", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1103, "y" : 230 }, "minX" : 1075, "maxX" : 1232, "minY" : 224, "maxY" : 236, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1075, "y" : 229 }, "to" : { "x" : 1103, "y" : 230 } }, { "from" : { "x" : 1103, "y" : 230 }, "to" : { "x" : 1232, "y" : 230 } } ], "endShape" : { "a" : { "x" : 1225, "y" : 234 }, "b" : { "x" : 1232, "y" : 230 }, "c" : { "x" : 1225, "y" : 226 }, "type" : "ARROW", "centre" : { "x" : 1225, "y" : 226 } }, "reactionShape" : { "a" : { "x" : 1097, "y" : 224 }, "b" : { "x" : 1109, "y" : 236 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1103, "y" : 230 } }, "inputs" : [ { "id" : 93482, "points" : [ { "x" : 1056, "y" : 260 } ] }, { "id" : 93483, "points" : [ { "x" : 1006, "y" : 227 } ] } ], "outputs" : [ { "id" : 93484 } ], "catalysts" : [ { "id" : 93485, "points" : [ { "x" : 1152, "y" : 259 } ] } ] }, { "id" : 93417, "reactomeId" : 10689046, "displayName" : "EXA4 is converted to EXC4 by LTC4S", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1032, "y" : 1133 }, "minX" : 1026, "maxX" : 1043, "minY" : 1107, "maxY" : 1169, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1032, "y" : 1107 }, "to" : { "x" : 1032, "y" : 1133 } }, { "from" : { "x" : 1032, "y" : 1133 }, "to" : { "x" : 1043, "y" : 1169 } } ], "endShape" : { "a" : { "x" : 1037, "y" : 1164 }, "b" : { "x" : 1043, "y" : 1169 }, "c" : { "x" : 1045, "y" : 1161 }, "type" : "ARROW", "centre" : { "x" : 1045, "y" : 1161 } }, "reactionShape" : { "a" : { "x" : 1026, "y" : 1127 }, "b" : { "x" : 1038, "y" : 1139 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1032, "y" : 1133 } }, "inputs" : [ { "id" : 93418, "points" : [ { "x" : 1032, "y" : 1095 } ] }, { "id" : 93408, "points" : [ { "x" : 1076, "y" : 1106 } ] } ], "outputs" : [ { "id" : 93419 } ], "catalysts" : [ { "id" : 93410, "points" : [ { "x" : 1426, "y" : 898 }, { "x" : 1292, "y" : 1004 }, { "x" : 1004, "y" : 1004 }, { "x" : 999, "y" : 1133 } ] } ] }, { "id" : 93546, "reactomeId" : 10726883, "displayName" : "11,12-EET is hydrolysed to 11,12-DHET by EPHX2", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1107, "y" : 135 }, "minX" : 1060, "maxX" : 1224, "minY" : 129, "maxY" : 141, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1060, "y" : 134 }, "to" : { "x" : 1107, "y" : 135 } }, { "from" : { "x" : 1107, "y" : 135 }, "to" : { "x" : 1224, "y" : 138 } } ], "endShape" : { "a" : { "x" : 1217, "y" : 142 }, "b" : { "x" : 1224, "y" : 138 }, "c" : { "x" : 1217, "y" : 134 }, "type" : "ARROW", "centre" : { "x" : 1217, "y" : 134 } }, "reactionShape" : { "a" : { "x" : 1101, "y" : 129 }, "b" : { "x" : 1113, "y" : 141 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1107, "y" : 135 } }, "inputs" : [ { "id" : 93547, "points" : [ { "x" : 1008, "y" : 132 } ] }, { "id" : 93482, "points" : [ { "x" : 1049, "y" : 260 } ] } ], "outputs" : [ { "id" : 93548 } ], "catalysts" : [ { "id" : 93485, "points" : [ { "x" : 1164, "y" : 259 } ] } ] }, { "id" : 93420, "reactomeId" : 10668015, "displayName" : "LTA4 is hydolysed to LTB4 by LTA4H", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 964, "y" : 1155 }, "minX" : 930, "maxX" : 1071, "minY" : 1149, "maxY" : 1161, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1071, "y" : 1155 }, "to" : { "x" : 964, "y" : 1155 } }, { "from" : { "x" : 964, "y" : 1155 }, "to" : { "x" : 930, "y" : 1156 } } ], "endShape" : { "a" : { "x" : 937, "y" : 1152 }, "b" : { "x" : 930, "y" : 1156 }, "c" : { "x" : 937, "y" : 1160 }, "type" : "ARROW", "centre" : { "x" : 937, "y" : 1160 } }, "reactionShape" : { "a" : { "x" : 958, "y" : 1149 }, "b" : { "x" : 970, "y" : 1161 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 964, "y" : 1155 } }, "inputs" : [ { "id" : 93407, "points" : [ { "x" : 1240, "y" : 1086 } ] }, { "id" : 93421, "points" : [ { "x" : 1187, "y" : 1192 } ] } ], "outputs" : [ { "id" : 93422 } ], "catalysts" : [ { "id" : 93423, "points" : [ { "x" : 963, "y" : 1193 } ] } ] }, { "id" : 93486, "reactomeId" : 10689100, "displayName" : "Arachidonate is oxidised to 12R-HpETE by ALOX12B", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1402, "y" : 677 }, "minX" : 1396, "maxX" : 1483, "minY" : 594, "maxY" : 702, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1402, "y" : 702 }, "to" : { "x" : 1402, "y" : 677 } }, { "from" : { "x" : 1402, "y" : 677 }, "to" : { "x" : 1483, "y" : 594 } } ], "endShape" : { "a" : { "x" : 1481, "y" : 602 }, "b" : { "x" : 1483, "y" : 594 }, "c" : { "x" : 1475, "y" : 596 }, "type" : "ARROW", "centre" : { "x" : 1475, "y" : 596 } }, "reactionShape" : { "a" : { "x" : 1396, "y" : 671 }, "b" : { "x" : 1408, "y" : 683 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1402, "y" : 677 } }, "inputs" : [ { "id" : 93416, "points" : [ { "x" : 1253, "y" : 789 } ] }, { "id" : 93487, "points" : [ { "x" : 1428, "y" : 715 } ] } ], "outputs" : [ { "id" : 93488 } ], "catalysts" : [ { "id" : 93489, "points" : [ { "x" : 1439, "y" : 675 } ] } ] }, { "id" : 93424, "reactomeId" : 10667290, "displayName" : "CYP4F2, 4F3 20-hydroxylate LTB4", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 795, "y" : 1156 }, "minX" : 755, "maxX" : 833, "minY" : 1150, "maxY" : 1162, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 833, "y" : 1157 }, "to" : { "x" : 795, "y" : 1156 } }, { "from" : { "x" : 795, "y" : 1156 }, "to" : { "x" : 755, "y" : 1156 } } ], "reactionShape" : { "a" : { "x" : 789, "y" : 1150 }, "b" : { "x" : 801, "y" : 1162 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 795, "y" : 1156 } }, "inputs" : [ { "id" : 93422, "points" : [ { "x" : 870, "y" : 1157 } ] }, { "id" : 93425, "points" : [ { "x" : 813, "y" : 1178 } ] }, { "id" : 93426, "points" : [ { "x" : 836, "y" : 1217 } ] }, { "id" : 93427, "points" : [ { "x" : 853, "y" : 1178 } ] } ], "outputs" : [ { "id" : 93428, "points" : [ { "x" : 730, "y" : 1156 } ] }, { "id" : 93429, "points" : [ { "x" : 734, "y" : 1177 } ] }, { "id" : 93430, "points" : [ { "x" : 756, "y" : 1218 } ] } ], "catalysts" : [ { "id" : 93431, "points" : [ { "x" : 682, "y" : 1113 }, { "x" : 794, "y" : 1125 } ] } ] }, { "id" : 93490, "reactomeId" : 10689117, "displayName" : "12R-HpETE is reduced to 12R-HETE by GPX1/2/4", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1494, "y" : 500 }, "minX" : 1488, "maxX" : 1500, "minY" : 474, "maxY" : 518, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1494, "y" : 518 }, "to" : { "x" : 1494, "y" : 500 } }, { "from" : { "x" : 1494, "y" : 500 }, "to" : { "x" : 1493, "y" : 474 } } ], "reactionShape" : { "a" : { "x" : 1488, "y" : 494 }, "b" : { "x" : 1500, "y" : 506 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1494, "y" : 500 } }, "inputs" : [ { "id" : 93488, "points" : [ { "x" : 1496, "y" : 558 } ] }, { "id" : 93491, "points" : [ { "x" : 1554, "y" : 546 } ], "stoichiometry" : 2 } ], "outputs" : [ { "id" : 93492, "points" : [ { "x" : 1493, "y" : 434 } ] }, { "id" : 93493, "points" : [ { "x" : 1549, "y" : 463 } ] }, { "id" : 93494, "points" : [ { "x" : 1557, "y" : 431 } ] } ], "catalysts" : [ { "id" : 93495, "points" : [ { "x" : 1531, "y" : 502 } ] } ] }, { "id" : 93496, "reactomeId" : 10689128, "displayName" : "12S-HpETE is reduced to 12S-HETE by GPX1/2/4", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1667, "y" : 501 }, "minX" : 1661, "maxX" : 1673, "minY" : 472, "maxY" : 519, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1666, "y" : 519 }, "to" : { "x" : 1667, "y" : 501 } }, { "from" : { "x" : 1667, "y" : 501 }, "to" : { "x" : 1666, "y" : 472 } } ], "reactionShape" : { "a" : { "x" : 1661, "y" : 495 }, "b" : { "x" : 1673, "y" : 507 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1667, "y" : 501 } }, "inputs" : [ { "id" : 93497, "points" : [ { "x" : 1667, "y" : 556 } ] }, { "id" : 93491, "points" : [ { "x" : 1605, "y" : 547 } ], "stoichiometry" : 2 } ], "outputs" : [ { "id" : 93494, "points" : [ { "x" : 1601, "y" : 431 } ] }, { "id" : 93498, "points" : [ { "x" : 1666, "y" : 432 } ] }, { "id" : 93493, "points" : [ { "x" : 1609, "y" : 462 } ] } ], "catalysts" : [ { "id" : 93495, "points" : [ { "x" : 1627, "y" : 503 } ] } ] }, { "id" : 93432, "reactomeId" : 10689043, "displayName" : "20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 591, "y" : 1153 }, "minX" : 548, "maxX" : 615, "minY" : 1147, "maxY" : 1159, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 615, "y" : 1154 }, "to" : { "x" : 591, "y" : 1153 } }, { "from" : { "x" : 591, "y" : 1153 }, "to" : { "x" : 548, "y" : 1153 } } ], "reactionShape" : { "a" : { "x" : 585, "y" : 1147 }, "b" : { "x" : 597, "y" : 1159 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 591, "y" : 1153 } }, "inputs" : [ { "id" : 93428, "points" : [ { "x" : 635, "y" : 1155 } ] }, { "id" : 93433, "points" : [ { "x" : 601, "y" : 1174 } ] }, { "id" : 93434, "points" : [ { "x" : 628, "y" : 1216 } ] }, { "id" : 93435, "points" : [ { "x" : 643, "y" : 1178 } ] } ], "outputs" : [ { "id" : 93436, "points" : [ { "x" : 512, "y" : 1153 } ] }, { "id" : 93437, "points" : [ { "x" : 547, "y" : 1215 } ], "stoichiometry" : 2 }, { "id" : 93438, "points" : [ { "x" : 522, "y" : 1178 } ] } ], "catalysts" : [ { "id" : 93431, "points" : [ { "x" : 591, "y" : 1132 } ] } ] }, { "id" : 93499, "reactomeId" : 10657633, "displayName" : "PLA2G4A (cPLA2) hydrolyzes phosphatidylcholine", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1025, "y" : 682 }, "minX" : 1019, "maxX" : 1031, "minY" : 654, "maxY" : 719, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1024, "y" : 654 }, "to" : { "x" : 1025, "y" : 682 } }, { "from" : { "x" : 1025, "y" : 682 }, "to" : { "x" : 1026, "y" : 719 } } ], "reactionShape" : { "a" : { "x" : 1019, "y" : 676 }, "b" : { "x" : 1031, "y" : 688 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1025, "y" : 682 } }, "inputs" : [ { "id" : 93500, "points" : [ { "x" : 992, "y" : 642 } ] }, { "id" : 93501, "points" : [ { "x" : 1052, "y" : 652 } ] } ], "outputs" : [ { "id" : 93502, "points" : [ { "x" : 997, "y" : 724 } ] }, { "id" : 93416, "points" : [ { "x" : 1209, "y" : 792 } ] }, { "id" : 93503, "points" : [ { "x" : 1076, "y" : 713 } ] } ], "catalysts" : [ { "id" : 93504, "points" : [ { "x" : 995, "y" : 680 } ] } ] }, { "id" : 93439, "reactomeId" : 10689066, "displayName" : "20cho-LTB4 is oxidised to 20cooh-LTB4 by CYP4F2/4F3", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 337, "y" : 1152 }, "minX" : 302, "maxX" : 365, "minY" : 1146, "maxY" : 1158, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 365, "y" : 1152 }, "to" : { "x" : 337, "y" : 1152 } }, { "from" : { "x" : 337, "y" : 1152 }, "to" : { "x" : 302, "y" : 1152 } } ], "reactionShape" : { "a" : { "x" : 331, "y" : 1146 }, "b" : { "x" : 343, "y" : 1158 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 337, "y" : 1152 } }, "inputs" : [ { "id" : 93436, "points" : [ { "x" : 405, "y" : 1152 } ] }, { "id" : 93440, "points" : [ { "x" : 331, "y" : 1220 } ] }, { "id" : 93441, "points" : [ { "x" : 380, "y" : 1204 } ] }, { "id" : 93442, "points" : [ { "x" : 401, "y" : 1177 } ] } ], "outputs" : [ { "id" : 93443, "points" : [ { "x" : 273, "y" : 1214 } ] }, { "id" : 93444, "points" : [ { "x" : 247, "y" : 1152 } ] }, { "id" : 93445, "points" : [ { "x" : 261, "y" : 1173 } ] } ], "catalysts" : [ { "id" : 93431, "points" : [ { "x" : 501, "y" : 1112 }, { "x" : 351, "y" : 1125 } ] } ] } ], "compartments" : [ { "id" : 93587, "reactomeId" : 13977, "displayName" : "lipid droplet", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 613, "y" : 1379 }, "minX" : 477, "maxX" : 749, "minY" : 1303, "maxY" : 1455, "prop" : { "x" : 477, "y" : 1303, "width" : 272, "height" : 152 }, "textPosition" : { "x" : 654, "y" : 1306 }, "insets" : { "x" : 487, "y" : 1313, "width" : 252, "height" : 132 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 93517, 93518, 93519, 93521, 93516, 93520 ] }, { "id" : 93549, "reactomeId" : 70101, "displayName" : "cytosol", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 1015, "y" : 741 }, "minX" : 0, "maxX" : 2031, "minY" : 0, "maxY" : 1483, "prop" : { "x" : 0, "y" : 0, "width" : 2031, "height" : 1483 }, "textPosition" : { "x" : 20, "y" : 1420 }, "insets" : { "x" : 10, "y" : 10, "width" : 2011, "height" : 1463 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 93550, 93551, 93406, 93409, 93412, 93416, 93418, 93417, 93419, 93420, 93421, 93422, 93423, 93428, 93425, 93426, 93424, 93427, 93436, 93437, 93438, 93433, 93434, 93435, 93432, 93439, 93443, 93444, 93445, 93442, 93441, 93440, 93451, 93468, 93469, 93465, 93466, 93464, 93470, 93472, 93473, 93474, 93467, 93477, 93478, 93476, 93479, 93475, 93480, 93483, 93481, 93485, 93486, 93488, 93489, 93487, 93490, 93492, 93491, 93493, 93495, 93497, 93496, 93494, 93498, 93429, 93430, 93598, 93511, 93513, 93587, 93407, 93408, 93411, 93413, 93415, 93414, 93514, 93512, 93527, 93528, 93529, 93597, 93599, 93596, 93530, 93531, 93532, 93499, 93503, 93501, 93533, 93534, 93535, 93536, 93537, 93539, 93538, 93541, 93547, 93544, 93482, 93484, 93540, 93542, 93543, 93545, 93546, 93548 ] }, { "id" : 93551, "reactomeId" : 13231, "displayName" : "nuclear envelope", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 1434, "y" : 839 }, "minX" : 1366, "maxX" : 1503, "minY" : 798, "maxY" : 880, "prop" : { "x" : 1366, "y" : 798, "width" : 137, "height" : 82 }, "textPosition" : { "x" : 1372, "y" : 814 }, "insets" : { "x" : 1376, "y" : 808, "width" : 117, "height" : 62 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 93410 ] }, { "id" : 93550, "reactomeId" : 17957, "displayName" : "endoplasmic reticulum lumen", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 720, "y" : 739 }, "minX" : 467, "maxX" : 974, "minY" : 357, "maxY" : 1122, "prop" : { "x" : 467, "y" : 357, "width" : 507, "height" : 765 }, "textPosition" : { "x" : 569, "y" : 379 }, "insets" : { "x" : 477, "y" : 367, "width" : 487, "height" : 745 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 93431, 93454, 93455, 93456, 93453, 93457, 93459, 93452, 93458, 93460, 93462, 93461, 93463, 93504, 93471, 93505, 93506, 93507, 93508, 93509, 93510, 93515, 93595, 93589, 93600, 93601, 93502, 93500 ] } ], "notes" : [ ], "links" : [ { "id" : 93601, "renderableClass" : "Interaction", "position" : { "x" : 801, "y" : 494 }, "minX" : 716, "maxX" : 886, "minY" : 451, "maxY" : 537, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 716, "y" : 537 }, "to" : { "x" : 886, "y" : 451 } } ], "endShape" : { "a" : { "x" : 882, "y" : 458 }, "b" : { "x" : 886, "y" : 451 }, "c" : { "x" : 878, "y" : 451 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 878, "y" : 451 } }, "reactionShape" : { "a" : { "x" : 795, "y" : 488 }, "b" : { "x" : 807, "y" : 500 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 801, "y" : 494 } }, "inputs" : [ { "id" : 93454 } ], "outputs" : [ { "id" : 93589 } ] }, { "id" : 93600, "renderableClass" : "Interaction", "position" : { "x" : 970, "y" : 467 }, "minX" : 964, "maxX" : 976, "minY" : 455, "maxY" : 480, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 970, "y" : 455 }, "to" : { "x" : 970, "y" : 480 } } ], "endShape" : { "a" : { "x" : 966, "y" : 473 }, "b" : { "x" : 970, "y" : 480 }, "c" : { "x" : 974, "y" : 473 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 974, "y" : 473 } }, "reactionShape" : { "a" : { "x" : 964, "y" : 461 }, "b" : { "x" : 976, "y" : 473 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 970, "y" : 467 } }, "inputs" : [ { "id" : 93589 } ], "outputs" : [ { "id" : 93471 } ] }, { "id" : 93597, "renderableClass" : "EntitySetAndEntitySetLink", "position" : { "x" : 460, "y" : 954 }, "minX" : 454, "maxX" : 466, "minY" : 938, "maxY" : 970, "segments" : [ { "from" : { "x" : 460, "y" : 970 }, "to" : { "x" : 460, "y" : 938 } } ], "reactionShape" : { "a" : { "x" : 454, "y" : 948 }, "b" : { "x" : 466, "y" : 960 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 460, "y" : 954 } }, "inputs" : [ { "id" : 93463 } ], "outputs" : [ { "id" : 93460 } ] }, { "id" : 93598, "renderableClass" : "EntitySetAndEntitySetLink", "position" : { "x" : 1456, "y" : 521 }, "minX" : 1381, "maxX" : 1531, "minY" : 510, "maxY" : 532, "segments" : [ { "from" : { "x" : 1381, "y" : 532 }, "to" : { "x" : 1531, "y" : 510 } } ], "reactionShape" : { "a" : { "x" : 1450, "y" : 515 }, "b" : { "x" : 1462, "y" : 527 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1456, "y" : 521 } }, "inputs" : [ { "id" : 93480 } ], "outputs" : [ { "id" : 93495 } ] } ], "shadows" : [ { "id" : 93603, "reactomeId" : 10729662, "displayName" : "Synthesis of 5-eicosatetraenoic acids", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 1594, "y" : 1214 }, "minX" : 1202, "maxX" : 1987, "minY" : 774, "maxY" : 1654, "prop" : { "x" : 1666, "y" : 826, "width" : 321, "height" : 771 }, "points" : [ { "x" : 1202, "y" : 774 }, { "x" : 1987, "y" : 774 }, { "x" : 1987, "y" : 1654 }, { "x" : 1202, "y" : 1654 } ], "colour" : "#dc3912" }, { "id" : 93602, "reactomeId" : 10729630, "displayName" : "Synthesis of Leukotrienes (LT) and Eoxins (EX)", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 890, "y" : 1185 }, "minX" : 114, "maxX" : 1666, "minY" : 774, "maxY" : 1597, "prop" : { "x" : 114, "y" : 1070, "width" : 1088, "height" : 527 }, "points" : [ { "x" : 114, "y" : 774 }, { "x" : 1666, "y" : 774 }, { "x" : 1666, "y" : 1597 }, { "x" : 114, "y" : 1597 } ], "colour" : "#4684ee" }, { "id" : 93605, "reactomeId" : 10730498, "displayName" : "Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE)", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 619, "y" : 795 }, "minX" : 423, "maxX" : 816, "minY" : 521, "maxY" : 1070, "prop" : { "x" : 423, "y" : 521, "width" : 393, "height" : 253 }, "points" : [ { "x" : 423, "y" : 521 }, { "x" : 816, "y" : 521 }, { "x" : 816, "y" : 1070 }, { "x" : 423, "y" : 1070 } ], "colour" : "#666666" }, { "id" : 93604, "reactomeId" : 10730496, "displayName" : "Synthesis of 15-eicosatetraenoic acid derivatives", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 1156, "y" : 631 }, "minX" : 924, "maxX" : 1388, "minY" : 436, "maxY" : 826, "prop" : { "x" : 924, "y" : 436, "width" : 278, "height" : 338 }, "points" : [ { "x" : 924, "y" : 436 }, { "x" : 1388, "y" : 436 }, { "x" : 1388, "y" : 826 }, { "x" : 924, "y" : 826 } ], "colour" : "#008000" }, { "id" : 93607, "reactomeId" : 10730502, "displayName" : "Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 1121, "y" : 178 }, "minX" : 913, "maxX" : 1330, "minY" : 52, "maxY" : 304, "prop" : { "x" : 913, "y" : 52, "width" : 417, "height" : 252 }, "points" : [ { "x" : 913, "y" : 52 }, { "x" : 1330, "y" : 52 }, { "x" : 1330, "y" : 304 }, { "x" : 913, "y" : 304 } ], "colour" : "#cb4ac5" }, { "id" : 93606, "reactomeId" : 10730500, "displayName" : "Synthesis of 12-eicosatetraenoic acid derivatives", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 1465, "y" : 583 }, "minX" : 1202, "maxX" : 1729, "minY" : 341, "maxY" : 826, "prop" : { "x" : 1388, "y" : 436, "width" : 341, "height" : 338 }, "points" : [ { "x" : 1202, "y" : 341 }, { "x" : 1729, "y" : 341 }, { "x" : 1729, "y" : 826 }, { "x" : 1202, "y" : 826 } ], "colour" : "#4942cc" } ], "minX" : 0, "maxX" : 2031, "minY" : 0, "maxY" : 1644, "disease" : false }