{
  "dbId" : 10729608,
  "stId" : "R-XTR-209776",
  "speciesName" : "Xenopus tropicalis",
  "nodes" : [ {
    "dbId" : 74113,
    "stId" : "R-ALL-74113",
    "displayName" : "Na+ [extracellular region]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 107638 ],
    "identifier" : "29101",
    "standardIdentifier" : "chebi:29101",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10668194,
    "stId" : "R-XTR-350873",
    "displayName" : "Ghost homologue of DIO3 [plasma membrane]",
    "schemaClass" : "GenomeEncodedEntity",
    "speciesId" : 205621,
    "parents" : [ 10668196 ],
    "children" : [ ]
  }, {
    "dbId" : 159362,
    "stId" : "R-ALL-159362",
    "displayName" : "DA [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 107619 ],
    "identifier" : "59905",
    "standardIdentifier" : "chebi:59905",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10666915,
    "stId" : "R-XTR-9961635-3",
    "displayName" : "Homologues of DUOXA1 [plasma membrane]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 205621,
    "parents" : [ 10666943 ],
    "children" : [ 10666909, 10666913 ]
  }, {
    "dbId" : 209794,
    "stId" : "R-ALL-209794",
    "displayName" : "ADR [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 107633 ],
    "identifier" : "71406",
    "standardIdentifier" : "chebi:71406",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 209793,
    "stId" : "R-ALL-209793",
    "displayName" : "Ac5HT [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 107688 ],
    "identifier" : "17697",
    "standardIdentifier" : "chebi:17697",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10666913,
    "stId" : "R-XTR-9961635-2",
    "displayName" : "duoxa1 [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 205621,
    "identifier" : "Q0P4G7",
    "standardIdentifier" : "uniprot:Q0P4G7",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "duoxa1" ],
    "parents" : [ 10666915 ],
    "children" : [ ]
  }, {
    "dbId" : 10668196,
    "stId" : "R-XTR-9965622",
    "displayName" : "DIO3 dimer [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 205621,
    "diagramIds" : [ 107680 ],
    "parents" : [ ],
    "children" : [ 10668194 ]
  }, {
    "dbId" : 351629,
    "stId" : "R-ALL-351629",
    "displayName" : "H2O2 [extracellular region]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 107645 ],
    "identifier" : "16240",
    "standardIdentifier" : "chebi:16240",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 351628,
    "stId" : "R-ALL-351628",
    "displayName" : "NADP+ [extracellular region]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 107649, 107665, 107701, 107657 ],
    "identifier" : "18009",
    "standardIdentifier" : "chebi:18009",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10666921,
    "stId" : "R-XTR-5693694",
    "displayName" : "phospho-duox1 [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 205621,
    "identifier" : "A0A6I8PSX5",
    "standardIdentifier" : "uniprot:A0A6I8PSX5",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "duox1" ],
    "parents" : [ 10666929 ],
    "children" : [ ]
  }, {
    "dbId" : 351630,
    "stId" : "R-ALL-351630",
    "displayName" : "I2 [extracellular region]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 107648 ],
    "identifier" : "17606",
    "standardIdentifier" : "chebi:17606",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10666927,
    "stId" : "R-XTR-5693694-2",
    "displayName" : "phospho-duox2 [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 205621,
    "identifier" : "F7ELQ0",
    "standardIdentifier" : "uniprot:F7ELQ0",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "duox2" ],
    "parents" : [ 10666929 ],
    "children" : [ ]
  }, {
    "dbId" : 209934,
    "stId" : "R-ALL-209934",
    "displayName" : "MLT [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 107693 ],
    "identifier" : "16796",
    "standardIdentifier" : "chebi:16796",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 351627,
    "stId" : "R-ALL-351627",
    "displayName" : "NADPH [extracellular region]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 107698, 107656, 107646 ],
    "identifier" : "16474",
    "standardIdentifier" : "chebi:16474",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 351626,
    "stId" : "R-ALL-351626",
    "displayName" : "H+ [extracellular region]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 107700, 107644, 107662 ],
    "identifier" : "15378",
    "standardIdentifier" : "chebi:15378",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 917919,
    "stId" : "R-ALL-917919",
    "displayName" : "heme [plasma membrane]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "identifier" : "60344",
    "standardIdentifier" : "chebi:60344",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ 10666941 ],
    "children" : [ ]
  }, {
    "dbId" : 10666931,
    "stId" : "R-XTR-9961686",
    "displayName" : "p-DUOX1:Ca2+ [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 205621,
    "parents" : [ 10666943 ],
    "children" : [ 140648, 10666929 ]
  }, {
    "dbId" : 351639,
    "stId" : "R-ALL-351639",
    "displayName" : "MIT [extracellular region]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 107654 ],
    "identifier" : "27847",
    "standardIdentifier" : "chebi:27847",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 209937,
    "stId" : "R-ALL-209937",
    "displayName" : "T4 [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 107675 ],
    "identifier" : "58448",
    "standardIdentifier" : "chebi:58448",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10666929,
    "stId" : "R-XTR-5693694-3",
    "displayName" : "Homologues of p-S955,S1217-DUOX1 [plasma membrane]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 205621,
    "parents" : [ 10666931 ],
    "children" : [ 10666927, 10666921 ]
  }, {
    "dbId" : 76183,
    "stId" : "R-ALL-76183",
    "displayName" : "Ac-CoA [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 107687 ],
    "identifier" : "57288",
    "standardIdentifier" : "chebi:57288",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10666933,
    "stId" : "R-XTR-534994",
    "displayName" : "cav1 [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 205621,
    "identifier" : "F7C9K9",
    "standardIdentifier" : "uniprot:F7C9K9",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "cav1" ],
    "parents" : [ 10666952, 10666943 ],
    "children" : [ ]
  }, {
    "dbId" : 10666939,
    "stId" : "R-XTR-2980604",
    "displayName" : "Ghost homologue of TPO [plasma membrane]",
    "schemaClass" : "GenomeEncodedEntity",
    "speciesId" : 205621,
    "parents" : [ 10666941 ],
    "children" : [ ]
  }, {
    "dbId" : 209818,
    "stId" : "R-ALL-209818",
    "displayName" : "I- [extracellular region]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 107639, 107659 ],
    "identifier" : "16382",
    "standardIdentifier" : "chebi:16382",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 176667,
    "stId" : "R-ALL-176667",
    "displayName" : "T3 [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 107678 ],
    "identifier" : "533015",
    "standardIdentifier" : "chebi:533015",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 71067,
    "stId" : "R-ALL-71067",
    "displayName" : "Fe2+ [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "identifier" : "29033",
    "standardIdentifier" : "chebi:29033",
    "chebiIdentifier" : "chebi:29033",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ 10666970 ],
    "children" : [ ]
  }, {
    "dbId" : 10666937,
    "stId" : "R-XTR-9961298",
    "displayName" : "txndc11 [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 205621,
    "identifier" : "Q0VA17",
    "standardIdentifier" : "uniprot:Q0VA17",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "txndc11" ],
    "parents" : [ 10666952, 10666943 ],
    "children" : [ ]
  }, {
    "dbId" : 352030,
    "stId" : "R-ALL-352030",
    "displayName" : "L-Tyr [extracellular region]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 107652, 107658 ],
    "identifier" : "58315",
    "standardIdentifier" : "chebi:58315",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10666943,
    "stId" : "R-XTR-9961426",
    "displayName" : "p-DUOX1:DUOXA1:TPO:CAV1:TXNDC11 [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 205621,
    "diagramIds" : [ 107702 ],
    "parents" : [ 10666954 ],
    "children" : [ 10666941, 10666937, 10666933, 10666931, 10666915 ]
  }, {
    "dbId" : 10666941,
    "stId" : "R-XTR-9961703",
    "displayName" : "TPO:Ca2+:heme [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 205621,
    "parents" : [ 10666952, 10666943 ],
    "children" : [ 140648, 10666939, 917919 ]
  }, {
    "dbId" : 352036,
    "stId" : "R-ALL-352036",
    "displayName" : "L-Ala [extracellular region]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 107669, 107673 ],
    "identifier" : "57972",
    "standardIdentifier" : "chebi:57972",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10667011,
    "stId" : "R-XTR-209957",
    "displayName" : "DBH tetramer [secretory granule lumen]",
    "schemaClass" : "Complex",
    "speciesId" : 205621,
    "diagramIds" : [ 107629 ],
    "parents" : [ ],
    "children" : [ 351594, 351602, 10667009 ]
  }, {
    "dbId" : 76194,
    "stId" : "R-ALL-76194",
    "displayName" : "CoA-SH [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 107689 ],
    "identifier" : "57287",
    "standardIdentifier" : "chebi:57287",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10667009,
    "stId" : "R-XTR-209790",
    "displayName" : "dbh [secretory granule lumen]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 205621,
    "identifier" : "F7BL08",
    "standardIdentifier" : "uniprot:F7BL08",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "dbh" ],
    "parents" : [ 10667011 ],
    "children" : [ ]
  }, {
    "dbId" : 10667018,
    "stId" : "R-XTR-209831",
    "displayName" : "PNMT [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 205621,
    "diagramIds" : [ 107636 ],
    "identifier" : "A0A8J0QU57",
    "standardIdentifier" : "uniprot:A0A8J0QU57",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10666895,
    "stId" : "R-XTR-350886",
    "displayName" : "DIO1 dimer [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 205621,
    "diagramIds" : [ 107682 ],
    "parents" : [ ],
    "children" : [ 10666893 ]
  }, {
    "dbId" : 29870,
    "stId" : "R-ALL-29870",
    "displayName" : "BH4 [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 107612 ],
    "identifier" : "59560",
    "standardIdentifier" : "chebi:59560",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10666893,
    "stId" : "R-XTR-2980823",
    "displayName" : "Ghost homologue of DIO1 [plasma membrane]",
    "schemaClass" : "GenomeEncodedEntity",
    "speciesId" : 205621,
    "parents" : [ 10666895 ],
    "children" : [ ]
  }, {
    "dbId" : 10667025,
    "stId" : "R-XTR-209833",
    "displayName" : "slc5a5 [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 205621,
    "diagramIds" : [ 107642 ],
    "identifier" : "B1WAW1",
    "standardIdentifier" : "uniprot:B1WAW1",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "slc5a5" ],
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 29364,
    "stId" : "R-ALL-29364",
    "displayName" : "NADPH [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 107677 ],
    "identifier" : "57783",
    "standardIdentifier" : "chebi:57783",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10666902,
    "stId" : "R-XTR-209813",
    "displayName" : "aanat [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 205621,
    "diagramIds" : [ 107690 ],
    "identifier" : "A0A8J0R7L3",
    "standardIdentifier" : "uniprot:A0A8J0R7L3",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "aanat" ],
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 73524,
    "stId" : "R-ALL-73524",
    "displayName" : "FMN [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "identifier" : "58210",
    "standardIdentifier" : "chebi:58210",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ 10667034 ],
    "children" : [ ]
  }, {
    "dbId" : 29366,
    "stId" : "R-ALL-29366",
    "displayName" : "NADP+ [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 107679 ],
    "identifier" : "58349",
    "standardIdentifier" : "chebi:58349",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10667034,
    "stId" : "R-XTR-209777",
    "displayName" : "IYD:FMN [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 205621,
    "diagramIds" : [ 107660 ],
    "parents" : [ ],
    "children" : [ 10667032, 73524 ]
  }, {
    "dbId" : 29368,
    "stId" : "R-ALL-29368",
    "displayName" : "O2 [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 107614 ],
    "identifier" : "15379",
    "standardIdentifier" : "chebi:15379",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10667032,
    "stId" : "R-XTR-3006480",
    "displayName" : "iyd [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 205621,
    "identifier" : "F7BBN5",
    "standardIdentifier" : "uniprot:F7BBN5",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "iyd" ],
    "parents" : [ 10667034 ],
    "children" : [ ]
  }, {
    "dbId" : 209849,
    "stId" : "R-ALL-209849",
    "displayName" : "L-Dopa [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 107615 ],
    "identifier" : "57504",
    "standardIdentifier" : "chebi:57504",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10666909,
    "stId" : "R-XTR-9961635",
    "displayName" : "LOC101733132 [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 205621,
    "identifier" : "A0A6I8PZQ1",
    "standardIdentifier" : "uniprot:A0A6I8PZQ1",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "LOC101733132" ],
    "parents" : [ 10666915 ],
    "children" : [ ]
  }, {
    "dbId" : 10666979,
    "stId" : "R-XTR-378967",
    "displayName" : "cga [extracellular region]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 205621,
    "identifier" : "F6W2E6",
    "standardIdentifier" : "uniprot:F6W2E6",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "cga" ],
    "parents" : [ 10666985 ],
    "children" : [ ]
  }, {
    "dbId" : 352327,
    "stId" : "R-ALL-352327",
    "displayName" : "O2 [extracellular region]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 107699 ],
    "identifier" : "15379",
    "standardIdentifier" : "chebi:15379",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 29506,
    "stId" : "R-ALL-29506",
    "displayName" : "L-Tyr [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 107613 ],
    "identifier" : "58315",
    "standardIdentifier" : "chebi:58315",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 352326,
    "stId" : "R-ALL-352326",
    "displayName" : "T4 [extracellular region]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 107672 ],
    "identifier" : "58448",
    "standardIdentifier" : "chebi:58448",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 622410,
    "stId" : "R-ALL-622410",
    "displayName" : "HI [extracellular region]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 107653 ],
    "identifier" : "43451",
    "standardIdentifier" : "chebi:43451",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10666983,
    "stId" : "R-XTR-378957",
    "displayName" : "tshb [extracellular region]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 205621,
    "identifier" : "A0A6I8RBV5",
    "standardIdentifier" : "uniprot:A0A6I8RBV5",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "tshb" ],
    "parents" : [ 10666985 ],
    "children" : [ ]
  }, {
    "dbId" : 83910,
    "stId" : "R-ALL-83910",
    "displayName" : "Na+ [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 107641 ],
    "identifier" : "29101",
    "standardIdentifier" : "chebi:29101",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 71112,
    "stId" : "R-ALL-71112",
    "displayName" : "4aOH-BH4 [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 107616 ],
    "identifier" : "15642",
    "standardIdentifier" : "chebi:15642",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10666985,
    "stId" : "R-XTR-378994",
    "displayName" : "Thyrotropin [extracellular region]",
    "schemaClass" : "Complex",
    "speciesId" : 205621,
    "diagramIds" : [ 107670 ],
    "parents" : [ ],
    "children" : [ 10666983, 10666979 ]
  }, {
    "dbId" : 352329,
    "stId" : "R-ALL-352329",
    "displayName" : "DIT [extracellular region]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 107663 ],
    "identifier" : "57506",
    "standardIdentifier" : "chebi:57506",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 352331,
    "stId" : "R-ALL-352331",
    "displayName" : "T3 [extracellular region]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 107668 ],
    "identifier" : "533015",
    "standardIdentifier" : "chebi:533015",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10667002,
    "stId" : "R-XTR-209895",
    "displayName" : "DDC dimer [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 205621,
    "diagramIds" : [ 107621 ],
    "parents" : [ ],
    "children" : [ 10667000 ]
  }, {
    "dbId" : 10667000,
    "stId" : "R-XTR-209810",
    "displayName" : "ddc [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 205621,
    "identifier" : "Q5M8I7",
    "standardIdentifier" : "uniprot:Q5M8I7",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "ddc" ],
    "parents" : [ 10667002 ],
    "children" : [ ]
  }, {
    "dbId" : 70106,
    "stId" : "R-ALL-70106",
    "displayName" : "H+ [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 107634, 107676, 107695 ],
    "identifier" : "15378",
    "standardIdentifier" : "chebi:15378",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 109276,
    "stId" : "R-ALL-109276",
    "displayName" : "H2O [extracellular region]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 107664, 107647 ],
    "identifier" : "15377",
    "standardIdentifier" : "chebi:15377",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10666945,
    "stId" : "R-XTR-9961463",
    "displayName" : "LOC101733132 [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 205621,
    "identifier" : "A0A6I8PZQ1",
    "standardIdentifier" : "uniprot:A0A6I8PZQ1",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "LOC101733132" ],
    "parents" : [ 10666952 ],
    "children" : [ ]
  }, {
    "dbId" : 10666950,
    "stId" : "R-XTR-9961578",
    "displayName" : "p-DUOX2:Ca2+ [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 205621,
    "parents" : [ 10666952 ],
    "children" : [ 140648, 10666948 ]
  }, {
    "dbId" : 10666948,
    "stId" : "R-XTR-5212693",
    "displayName" : "phospho-duox1 [plasma membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 205621,
    "identifier" : "A0A6I8PSX5",
    "standardIdentifier" : "uniprot:A0A6I8PSX5",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "duox1" ],
    "parents" : [ 10666950 ],
    "children" : [ ]
  }, {
    "dbId" : 10666954,
    "stId" : "R-XTR-9961429",
    "displayName" : "p-DUOX1,2:DUOXA1,2:TPO:CAV1:TXNDC11 [plasma membrane]",
    "schemaClass" : "DefinedSet",
    "speciesId" : 205621,
    "diagramIds" : [ 107650 ],
    "parents" : [ ],
    "children" : [ 10666943, 10666952 ]
  }, {
    "dbId" : 351597,
    "stId" : "R-ALL-351597",
    "displayName" : "NAd [secretory granule lumen]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 107626 ],
    "identifier" : "72587",
    "standardIdentifier" : "chebi:72587",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10666952,
    "stId" : "R-XTR-9961346",
    "displayName" : "p-DUOX2:DUOXA2:TPO:CAV1:TXNDC11 [plasma membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 205621,
    "parents" : [ 10666954 ],
    "children" : [ 10666941, 10666937, 10666933, 10666950, 10666945 ]
  }, {
    "dbId" : 140648,
    "stId" : "R-ALL-140648",
    "displayName" : "Ca2+ [plasma membrane]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "identifier" : "29108",
    "standardIdentifier" : "chebi:29108",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ 10666950, 10666941, 10666931 ],
    "children" : [ ]
  }, {
    "dbId" : 351599,
    "stId" : "R-ALL-351599",
    "displayName" : "DeHA [secretory granule lumen]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 107627 ],
    "identifier" : "58539",
    "standardIdentifier" : "chebi:58539",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 351593,
    "stId" : "R-ALL-351593",
    "displayName" : "O2 [secretory granule lumen]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 107624 ],
    "identifier" : "15379",
    "standardIdentifier" : "chebi:15379",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 351595,
    "stId" : "R-ALL-351595",
    "displayName" : "AscH- [secretory granule lumen]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 107623 ],
    "identifier" : "38290",
    "standardIdentifier" : "chebi:38290",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 351594,
    "stId" : "R-ALL-351594",
    "displayName" : "PQQ [secretory granule lumen]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "identifier" : "18315",
    "standardIdentifier" : "chebi:18315",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ 10667011 ],
    "children" : [ ]
  }, {
    "dbId" : 10666961,
    "stId" : "R-XTR-2976652",
    "displayName" : "asmt [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 205621,
    "diagramIds" : [ 107696 ],
    "identifier" : "A0A6I8PZD3",
    "standardIdentifier" : "uniprot:A0A6I8PZD3",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "asmt" ],
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 71285,
    "stId" : "R-ALL-71285",
    "displayName" : "AdoHcy [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 107635, 107694 ],
    "identifier" : "57856",
    "standardIdentifier" : "chebi:57856",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 209911,
    "stId" : "R-ALL-209911",
    "displayName" : "5HTP [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 107684 ],
    "identifier" : "58266",
    "standardIdentifier" : "chebi:58266",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 351601,
    "stId" : "R-ALL-351601",
    "displayName" : "DA [clathrin-sculpted monoamine transport vesicle lumen]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 107625 ],
    "identifier" : "59905",
    "standardIdentifier" : "chebi:59905",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 71284,
    "stId" : "R-ALL-71284",
    "displayName" : "AdoMet [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 107632, 107692 ],
    "identifier" : "59789",
    "standardIdentifier" : "chebi:59789",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 351603,
    "stId" : "R-ALL-351603",
    "displayName" : "H2O [secretory granule lumen]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 107628 ],
    "identifier" : "15377",
    "standardIdentifier" : "chebi:15377",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 351602,
    "stId" : "R-ALL-351602",
    "displayName" : "Cu2+ [secretory granule lumen]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "identifier" : "28694",
    "standardIdentifier" : "chebi:28694",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ 10667011 ],
    "children" : [ ]
  }, {
    "dbId" : 10666970,
    "stId" : "R-XTR-209926",
    "displayName" : "TH:Fe2+ [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 205621,
    "diagramIds" : [ 107617 ],
    "parents" : [ ],
    "children" : [ 10666968, 71067 ]
  }, {
    "dbId" : 209914,
    "stId" : "R-ALL-209914",
    "displayName" : "5HT [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 107685 ],
    "identifier" : "350546",
    "standardIdentifier" : "chebi:350546",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 113528,
    "stId" : "R-ALL-113528",
    "displayName" : "CO2 [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 107620 ],
    "identifier" : "16526",
    "standardIdentifier" : "chebi:16526",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 209785,
    "stId" : "R-ALL-209785",
    "displayName" : "I- [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 107640 ],
    "identifier" : "16382",
    "standardIdentifier" : "chebi:16382",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10666968,
    "stId" : "R-XTR-2980863",
    "displayName" : "TH [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 205621,
    "identifier" : "F6QRF6",
    "standardIdentifier" : "uniprot:F6QRF6",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10666970 ],
    "children" : [ ]
  }, {
    "dbId" : 209789,
    "stId" : "R-ALL-209789",
    "displayName" : "NAd [cytosol]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 107631 ],
    "identifier" : "72587",
    "standardIdentifier" : "chebi:72587",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  } ],
  "edges" : [ {
    "dbId" : 10667041,
    "stId" : "R-XTR-209925",
    "displayName" : "DIT and MIT combine to form triiodothyronine",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10666957, 10667049 ],
    "inputs" : [ 352329, 351639 ],
    "outputs" : [ 352331, 352036 ],
    "catalysts" : [ 10666954 ],
    "efs" : [ ],
    "activators" : [ 10666985 ],
    "diagramIds" : [ 107667 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10667014,
    "stId" : "R-XTR-209891",
    "displayName" : "Dopamine is oxidised to noradrenaline",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 351595, 351593, 351601 ],
    "outputs" : [ 351599, 351597, 351603 ],
    "catalysts" : [ 10667011 ],
    "efs" : [ ],
    "diagramIds" : [ 107622 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10667047,
    "stId" : "R-XTR-209960",
    "displayName" : "Diiodinated tyrosine can be deiodinated",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10667049 ],
    "following" : [ 10667049 ],
    "inputs" : [ 351627, 352329 ],
    "outputs" : [ 352030, 351628, 209818 ],
    "catalysts" : [ 10667034 ],
    "efs" : [ ],
    "diagramIds" : [ 107666 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10668199,
    "stId" : "R-XTR-350869",
    "displayName" : "Thyroxine is deiodinated to reverse triiodothyronine (RT3)",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 70106, 29364, 209937 ],
    "outputs" : [ 209785, 176667, 29366 ],
    "catalysts" : [ 10668196 ],
    "efs" : [ ],
    "diagramIds" : [ 107674 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10704037,
    "stId" : "R-XTR-5693681",
    "displayName" : "DUOX1 reduces O2 to H2O2",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 351626, 351627, 352327 ],
    "outputs" : [ 351628, 351629 ],
    "catalysts" : [ 10666943 ],
    "efs" : [ ],
    "diagramIds" : [ 107697 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10666987,
    "stId" : "R-XTR-209840",
    "displayName" : "Two DITs combine to form thyroxine",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10667049 ],
    "following" : [ 10666898 ],
    "inputs" : [ 352329 ],
    "outputs" : [ 352326, 352036 ],
    "catalysts" : [ 10666954 ],
    "efs" : [ ],
    "activators" : [ 10666985 ],
    "diagramIds" : [ 107671 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10668201,
    "stId" : "R-XTR-350901",
    "displayName" : "Iodide is organified",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "following" : [ 10667049, 10666957 ],
    "inputs" : [ 351626, 351627, 209818, 351629 ],
    "outputs" : [ 109276, 351630, 351628 ],
    "catalysts" : [ 10666954 ],
    "efs" : [ ],
    "diagramIds" : [ 107643 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10667049,
    "stId" : "R-XTR-209973",
    "displayName" : "Tyrosine is diiodinated",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10668201, 10667047 ],
    "following" : [ 10667041, 10666987, 10667047 ],
    "inputs" : [ 351626, 351627, 352030, 209818, 351629 ],
    "outputs" : [ 109276, 352329, 351628 ],
    "catalysts" : [ 10666954 ],
    "efs" : [ ],
    "diagramIds" : [ 107661 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10666957,
    "stId" : "R-XTR-209815",
    "displayName" : "Tyrosine is monoiodinated",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10667037, 10668201 ],
    "following" : [ 10667041 ],
    "inputs" : [ 351630, 352030 ],
    "outputs" : [ 622410, 351639 ],
    "catalysts" : [ 10666954 ],
    "efs" : [ ],
    "diagramIds" : [ 107651 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10667021,
    "stId" : "R-XTR-209903",
    "displayName" : "Noradrenaline is converted to adrenaline",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 209789, 71284 ],
    "outputs" : [ 70106, 71285, 209794 ],
    "catalysts" : [ 10667018 ],
    "efs" : [ ],
    "diagramIds" : [ 107630 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10666898,
    "stId" : "R-XTR-209772",
    "displayName" : "Thyroxine is deiodinated to triiodothyronine",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10666987 ],
    "inputs" : [ 70106, 29364, 209937 ],
    "outputs" : [ 209785, 176667, 29366 ],
    "catalysts" : [ 10666895 ],
    "efs" : [ ],
    "diagramIds" : [ 107681 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10667028,
    "stId" : "R-XTR-209910",
    "displayName" : "Iodide is taken up by thyroid epithelial cells",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "inputs" : [ 209818, 74113 ],
    "outputs" : [ 209785, 83910 ],
    "catalysts" : [ 10667025 ],
    "efs" : [ ],
    "diagramIds" : [ 107637 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10666964,
    "stId" : "R-XTR-209821",
    "displayName" : "Methylation of N-acetyl-5-HT to form melatonin",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10666905 ],
    "inputs" : [ 71284, 209793 ],
    "outputs" : [ 209934, 70106, 71285 ],
    "catalysts" : [ 10666961 ],
    "efs" : [ ],
    "diagramIds" : [ 107691 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10666905,
    "stId" : "R-XTR-209792",
    "displayName" : "N-acetylation of serotonin",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10667005 ],
    "following" : [ 10666964 ],
    "inputs" : [ 209914, 76183 ],
    "outputs" : [ 76194, 209793 ],
    "catalysts" : [ 10666902 ],
    "efs" : [ ],
    "diagramIds" : [ 107686 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10667039,
    "stId" : "R-XTR-209924",
    "displayName" : "Dopa is decarboxylated to dopamine",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10666973 ],
    "inputs" : [ 209849 ],
    "outputs" : [ 113528, 159362 ],
    "catalysts" : [ 10667002 ],
    "efs" : [ ],
    "diagramIds" : [ 107618 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10667037,
    "stId" : "R-XTR-209921",
    "displayName" : "Monoiodinated tyrosine can be deiodinated",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "following" : [ 10666957 ],
    "inputs" : [ 351627, 351639 ],
    "outputs" : [ 352030, 351628, 209818 ],
    "catalysts" : [ 10667034 ],
    "efs" : [ ],
    "diagramIds" : [ 107655 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10667005,
    "stId" : "R-XTR-209859",
    "displayName" : "Decarboxylation of 5-hydroxytryptophan forms serotonin",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "following" : [ 10666905 ],
    "inputs" : [ 209911 ],
    "outputs" : [ 113528, 209914 ],
    "catalysts" : [ 10667002 ],
    "efs" : [ ],
    "diagramIds" : [ 107683 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10666973,
    "stId" : "R-XTR-209823",
    "displayName" : "Tyrosine is hydroxylated to dopa",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "following" : [ 10667039 ],
    "inputs" : [ 29870, 29368, 29506 ],
    "outputs" : [ 209849, 71112 ],
    "catalysts" : [ 10666970 ],
    "efs" : [ ],
    "diagramIds" : [ 107611 ],
    "entityFunctionalStatus" : [ ]
  } ],
  "subpathways" : [ {
    "dbId" : 10729612,
    "stId" : "R-XTR-209905",
    "displayName" : "Catecholamine biosynthesis",
    "events" : [ 10667014, 10667039, 10666973, 10667021 ]
  }, {
    "dbId" : 10729610,
    "stId" : "R-XTR-209931",
    "displayName" : "Serotonin and melatonin biosynthesis",
    "events" : [ 10666964, 10666905, 10667005 ]
  }, {
    "dbId" : 10729604,
    "stId" : "R-XTR-350864",
    "displayName" : "Regulation of thyroid hormone activity",
    "events" : [ 10666898, 10668199 ]
  }, {
    "dbId" : 10729606,
    "stId" : "R-XTR-209968",
    "displayName" : "Thyroxine biosynthesis",
    "events" : [ 10667041, 10667047, 10667028, 10704037, 10666898, 10668199, 10666987, 10668201, 10667049, 10666957, 10667037 ]
  } ]
}