{
  "dbId" : 10730516,
  "stableId" : "R-XTR-1980145",
  "displayName" : "Signaling by NOTCH2",
  "nodes" : [ {
    "id" : 144547,
    "reactomeId" : 10667532,
    "displayName" : "MAML",
    "schemaClass" : "CandidateSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 697,
      "y" : 587
    },
    "minX" : 667,
    "maxX" : 722,
    "minY" : 576,
    "maxY" : 624,
    "prop" : {
      "x" : 672,
      "y" : 576,
      "width" : 50,
      "height" : 22
    },
    "textPosition" : {
      "x" : 676,
      "y" : 576
    },
    "connectors" : [ {
      "edgeId" : 144546,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 688,
          "y" : 604
        },
        "to" : {
          "x" : 667,
          "y" : 624
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 144550,
    "reactomeId" : 10689728,
    "displayName" : "NOTCH2 Coactivator Complex",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 843,
      "y" : 613
    },
    "minX" : 791,
    "maxX" : 901,
    "minY" : 584,
    "maxY" : 637,
    "prop" : {
      "x" : 791,
      "y" : 590,
      "width" : 104,
      "height" : 47
    },
    "textPosition" : {
      "x" : 801,
      "y" : 588
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 895,
          "y" : 590
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 895,
          "y" : 590
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 144546,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 144567,
    "reactomeId" : 10730450,
    "displayName" : "Signaling by NOTCH1",
    "schemaClass" : "Pathway",
    "renderableClass" : "EncapsulatedNode",
    "position" : {
      "x" : 782,
      "y" : 1066
    },
    "minX" : 708,
    "maxX" : 857,
    "minY" : 1046,
    "maxY" : 1087,
    "prop" : {
      "x" : 708,
      "y" : 1046,
      "width" : 149,
      "height" : 41
    },
    "textPosition" : {
      "x" : 710,
      "y" : 1052
    },
    "connectors" : [ ]
  }, {
    "id" : 144548,
    "reactomeId" : 10667504,
    "displayName" : "rbpj",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 637,
      "y" : 607
    },
    "minX" : 619,
    "maxX" : 667,
    "minY" : 590,
    "maxY" : 624,
    "prop" : {
      "x" : 619,
      "y" : 596,
      "width" : 36,
      "height" : 22
    },
    "textPosition" : {
      "x" : 621,
      "y" : 596
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 655,
          "y" : 596
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 655,
          "y" : 596
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 144546,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 658,
          "y" : 617
        },
        "to" : {
          "x" : 667,
          "y" : 624
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 144564,
    "reactomeId" : 10730456,
    "displayName" : "Pre-NOTCH Expression and Processing",
    "schemaClass" : "Pathway",
    "renderableClass" : "EncapsulatedNode",
    "position" : {
      "x" : 629,
      "y" : 224
    },
    "minX" : 495,
    "maxX" : 763,
    "minY" : 201,
    "maxY" : 247,
    "prop" : {
      "x" : 495,
      "y" : 201,
      "width" : 268,
      "height" : 46
    },
    "textPosition" : {
      "x" : 501,
      "y" : 209
    },
    "connectors" : [ ]
  }, {
    "id" : 144549,
    "reactomeId" : 10667508,
    "displayName" : "NICD2",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 604,
      "y" : 730
    },
    "minX" : 581,
    "maxX" : 667,
    "minY" : 624,
    "maxY" : 741,
    "prop" : {
      "x" : 581,
      "y" : 719,
      "width" : 46,
      "height" : 22
    },
    "textPosition" : {
      "x" : 581,
      "y" : 719
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 627,
          "y" : 719
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 627,
          "y" : 719
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 144546,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 610,
          "y" : 716
        },
        "to" : {
          "x" : 667,
          "y" : 624
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 144554,
    "reactomeId" : 10691918,
    "displayName" : "MDK:NOTCH2",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 290,
      "y" : 1164
    },
    "minX" : 259,
    "maxX" : 328,
    "minY" : 1141,
    "maxY" : 1181,
    "prop" : {
      "x" : 259,
      "y" : 1147,
      "width" : 63,
      "height" : 34
    },
    "textPosition" : {
      "x" : 261,
      "y" : 1146
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 322,
          "y" : 1147
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 322,
          "y" : 1147
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 144551,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 144552,
    "reactomeId" : 10691916,
    "displayName" : "MDK",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 243,
      "y" : 1219
    },
    "minX" : 225,
    "maxX" : 292,
    "minY" : 1202,
    "maxY" : 1230,
    "prop" : {
      "x" : 225,
      "y" : 1208,
      "width" : 36,
      "height" : 22
    },
    "textPosition" : {
      "x" : 226,
      "y" : 1209
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 261,
          "y" : 1208
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 261,
          "y" : 1208
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 144551,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 264,
          "y" : 1221
        },
        "to" : {
          "x" : 292,
          "y" : 1226
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 144553,
    "reactomeId" : 10686008,
    "displayName" : "NOTCH2",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 292,
      "y" : 1260
    },
    "minX" : 262,
    "maxX" : 328,
    "minY" : 1226,
    "maxY" : 1271,
    "prop" : {
      "x" : 262,
      "y" : 1249,
      "width" : 60,
      "height" : 22
    },
    "textPosition" : {
      "x" : 263,
      "y" : 1250
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 322,
          "y" : 1249
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 322,
          "y" : 1249
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 144551,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 292,
          "y" : 1246
        },
        "to" : {
          "x" : 292,
          "y" : 1226
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  } ],
  "edges" : [ {
    "id" : 144546,
    "reactomeId" : 10689730,
    "displayName" : "NICD2 binds RBPJ and MAML in the nucleus",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 686,
      "y" : 631
    },
    "minX" : 667,
    "maxX" : 788,
    "minY" : 618,
    "maxY" : 637,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 667,
        "y" : 624
      },
      "to" : {
        "x" : 686,
        "y" : 631
      }
    }, {
      "from" : {
        "x" : 686,
        "y" : 631
      },
      "to" : {
        "x" : 788,
        "y" : 618
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 782,
        "y" : 623
      },
      "b" : {
        "x" : 788,
        "y" : 618
      },
      "c" : {
        "x" : 781,
        "y" : 615
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 781,
        "y" : 615
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 686,
        "y" : 631
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 686,
        "y" : 631
      }
    },
    "inputs" : [ {
      "id" : 144547,
      "points" : [ {
        "x" : 688,
        "y" : 604
      } ]
    }, {
      "id" : 144548,
      "points" : [ {
        "x" : 658,
        "y" : 617
      } ]
    }, {
      "id" : 144549,
      "points" : [ {
        "x" : 610,
        "y" : 716
      } ]
    } ],
    "outputs" : [ {
      "id" : 144550
    } ]
  }, {
    "id" : 144551,
    "reactomeId" : 10691920,
    "displayName" : "NOTCH2 binds MDK",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 291,
      "y" : 1211
    },
    "minX" : 285,
    "maxX" : 297,
    "minY" : 1184,
    "maxY" : 1226,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 292,
        "y" : 1226
      },
      "to" : {
        "x" : 291,
        "y" : 1211
      }
    }, {
      "from" : {
        "x" : 291,
        "y" : 1211
      },
      "to" : {
        "x" : 290,
        "y" : 1184
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 294,
        "y" : 1191
      },
      "b" : {
        "x" : 290,
        "y" : 1184
      },
      "c" : {
        "x" : 286,
        "y" : 1191
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 286,
        "y" : 1191
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 291,
        "y" : 1211
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 291,
        "y" : 1211
      }
    },
    "inputs" : [ {
      "id" : 144552,
      "points" : [ {
        "x" : 264,
        "y" : 1221
      } ]
    }, {
      "id" : 144553,
      "points" : [ {
        "x" : 292,
        "y" : 1246
      } ]
    } ],
    "outputs" : [ {
      "id" : 144554
    } ]
  } ],
  "compartments" : [ {
    "id" : 144555,
    "reactomeId" : 70101,
    "displayName" : "cytosol",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 106,
      "y" : 710
    },
    "minX" : 0,
    "maxX" : 213,
    "minY" : 0,
    "maxY" : 1420,
    "prop" : {
      "x" : 0,
      "y" : 0,
      "width" : 213,
      "height" : 1420
    },
    "textPosition" : {
      "x" : 21,
      "y" : 667
    },
    "insets" : {
      "x" : 10,
      "y" : 10,
      "width" : 193,
      "height" : 1400
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 144559 ]
  }, {
    "id" : 144558,
    "reactomeId" : 7660,
    "displayName" : "nucleoplasm",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 793,
      "y" : 723
    },
    "minX" : 538,
    "maxX" : 1049,
    "minY" : 326,
    "maxY" : 1120,
    "prop" : {
      "x" : 538,
      "y" : 326,
      "width" : 511,
      "height" : 794
    },
    "textPosition" : {
      "x" : 567,
      "y" : 1069
    },
    "insets" : {
      "x" : 548,
      "y" : 336,
      "width" : 491,
      "height" : 774
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 144549, 144550, 144546, 144547, 144548, 144567, 144575, 144576 ]
  }, {
    "id" : 144556,
    "reactomeId" : 70101,
    "displayName" : "cytosol",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 712,
      "y" : 715
    },
    "minX" : 265,
    "maxX" : 1160,
    "minY" : 13,
    "maxY" : 1418,
    "prop" : {
      "x" : 265,
      "y" : 13,
      "width" : 895,
      "height" : 1405
    },
    "textPosition" : {
      "x" : 335,
      "y" : 728
    },
    "insets" : {
      "x" : 275,
      "y" : 23,
      "width" : 875,
      "height" : 1385
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 144558, 144560, 144571, 144572, 144570, 144569, 144564, 144573, 144553, 144554, 144551, 144568, 144577, 144578 ]
  } ],
  "notes" : [ {
    "id" : 144560,
    "displayName" : "Signal Receiving Cell",
    "renderableClass" : "Note",
    "position" : {
      "x" : 547,
      "y" : 1368
    },
    "minX" : 482,
    "maxX" : 613,
    "minY" : 1357,
    "maxY" : 1379,
    "prop" : {
      "x" : 482,
      "y" : 1357,
      "width" : 131,
      "height" : 22
    },
    "textPosition" : {
      "x" : 491,
      "y" : 1351
    }
  }, {
    "id" : 144559,
    "displayName" : "Signal Sending Cell",
    "renderableClass" : "Note",
    "position" : {
      "x" : 114,
      "y" : 1346
    },
    "minX" : 43,
    "maxX" : 186,
    "minY" : 1335,
    "maxY" : 1357,
    "prop" : {
      "x" : 43,
      "y" : 1335,
      "width" : 143,
      "height" : 22
    },
    "textPosition" : {
      "x" : 51,
      "y" : 1335
    }
  } ],
  "links" : [ {
    "id" : 144574,
    "renderableClass" : "FlowLine",
    "position" : {
      "x" : 1206,
      "y" : 642
    },
    "minX" : 766,
    "maxX" : 1212,
    "minY" : 222,
    "maxY" : 1065,
    "segments" : [ {
      "from" : {
        "x" : 766,
        "y" : 223
      },
      "to" : {
        "x" : 1206,
        "y" : 222
      }
    }, {
      "from" : {
        "x" : 1206,
        "y" : 222
      },
      "to" : {
        "x" : 1206,
        "y" : 1063
      }
    }, {
      "from" : {
        "x" : 1206,
        "y" : 1063
      },
      "to" : {
        "x" : 860,
        "y" : 1065
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 867,
        "y" : 1061
      },
      "b" : {
        "x" : 860,
        "y" : 1065
      },
      "c" : {
        "x" : 867,
        "y" : 1069
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 867,
        "y" : 1069
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 1200,
        "y" : 636
      },
      "b" : {
        "x" : 1212,
        "y" : 648
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1206,
        "y" : 642
      }
    },
    "inputs" : [ {
      "id" : 144564
    } ],
    "outputs" : [ {
      "id" : 144567
    } ]
  } ],
  "shadows" : [ {
    "id" : 144576,
    "reactomeId" : 10730586,
    "displayName" : "NOTCH2 Activation and Transmission of Signal to the Nucleus",
    "schemaClass" : "Pathway",
    "renderableClass" : "Shadow",
    "position" : {
      "x" : 273,
      "y" : 1209
    },
    "minX" : 215,
    "maxX" : 332,
    "minY" : 1137,
    "maxY" : 1281,
    "prop" : {
      "x" : 215,
      "y" : 1137,
      "width" : 117,
      "height" : 144
    },
    "points" : [ {
      "x" : 215,
      "y" : 1137
    }, {
      "x" : 332,
      "y" : 1137
    }, {
      "x" : 332,
      "y" : 1281
    }, {
      "x" : 215,
      "y" : 1281
    } ],
    "colour" : "#dc3912"
  }, {
    "id" : 144575,
    "reactomeId" : 10730514,
    "displayName" : "NOTCH2 intracellular domain regulates transcription",
    "schemaClass" : "Pathway",
    "renderableClass" : "Shadow",
    "position" : {
      "x" : 738,
      "y" : 658
    },
    "minX" : 571,
    "maxX" : 905,
    "minY" : 566,
    "maxY" : 751,
    "prop" : {
      "x" : 571,
      "y" : 566,
      "width" : 334,
      "height" : 185
    },
    "points" : [ {
      "x" : 571,
      "y" : 566
    }, {
      "x" : 905,
      "y" : 566
    }, {
      "x" : 905,
      "y" : 751
    }, {
      "x" : 571,
      "y" : 751
    } ],
    "colour" : "#4684ee"
  } ],
  "minX" : 0,
  "maxX" : 1212,
  "minY" : 0,
  "maxY" : 1420,
  "disease" : false
}