{
  "dbId" : 10730204,
  "stableId" : "R-XTR-1170546",
  "displayName" : "Prolactin receptor signaling",
  "nodes" : [ {
    "id" : 106880,
    "reactomeId" : 10679517,
    "displayName" : "PRLR ligands:Activated PRLR:p-Y1007-JAK2 dimer",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 137,
      "y" : 643
    },
    "minX" : 86,
    "maxX" : 194,
    "minY" : 604,
    "maxY" : 677,
    "prop" : {
      "x" : 86,
      "y" : 610,
      "width" : 102,
      "height" : 67
    },
    "textPosition" : {
      "x" : 88,
      "y" : 614
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 188,
          "y" : 610
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 188,
          "y" : 610
        }
      }
    },
    "connectors" : [ ]
  }, {
    "id" : 106851,
    "reactomeId" : 10679286,
    "displayName" : "PRLR:JAK2 dimer",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 248,
      "y" : 25
    },
    "minX" : 214,
    "maxX" : 289,
    "minY" : 1,
    "maxY" : 60,
    "prop" : {
      "x" : 214,
      "y" : 7,
      "width" : 69,
      "height" : 36
    },
    "textPosition" : {
      "x" : 213,
      "y" : 8
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 283,
          "y" : 7
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 283,
          "y" : 7
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 106849,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 235,
          "y" : 46
        },
        "to" : {
          "x" : 223,
          "y" : 60
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 106854,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 106850,
    "reactomeId" : 10679278,
    "displayName" : "prl",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 139,
      "y" : 24
    },
    "minX" : 82,
    "maxX" : 223,
    "minY" : 0,
    "maxY" : 60,
    "prop" : {
      "x" : 82,
      "y" : 6,
      "width" : 115,
      "height" : 36
    },
    "textPosition" : {
      "x" : 127,
      "y" : 13
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 197,
          "y" : 6
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 197,
          "y" : 6
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 106849,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 181,
          "y" : 48
        },
        "to" : {
          "x" : 223,
          "y" : 60
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 106853,
    "reactomeId" : 10679299,
    "displayName" : "PRLR ligands:p-S349- PRLR:JAK2 dimer:SCF beta-TrCP complex",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 581,
      "y" : 392
    },
    "minX" : 253,
    "maxX" : 651,
    "minY" : 82,
    "maxY" : 430,
    "prop" : {
      "x" : 517,
      "y" : 355,
      "width" : 128,
      "height" : 75
    },
    "textPosition" : {
      "x" : 525,
      "y" : 367
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 645,
          "y" : 355
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 645,
          "y" : 355
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 106849,
      "type" : "INHIBITOR",
      "segments" : [ {
        "from" : {
          "x" : 541,
          "y" : 352
        },
        "to" : {
          "x" : 256,
          "y" : 85
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 253,
          "y" : 88
        },
        "b" : {
          "x" : 259,
          "y" : 82
        },
        "c" : {
          "x" : 256,
          "y" : 85
        },
        "type" : "STOP",
        "centre" : {
          "x" : 256,
          "y" : 85
        }
      }
    }, {
      "edgeId" : 106856,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 106859,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 106852,
    "reactomeId" : 10679288,
    "displayName" : "PRLR ligands:PRLR:JAK2 dimer",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 146,
      "y" : 82
    },
    "minX" : 90,
    "maxX" : 209,
    "minY" : 58,
    "maxY" : 100,
    "prop" : {
      "x" : 90,
      "y" : 64,
      "width" : 113,
      "height" : 36
    },
    "textPosition" : {
      "x" : 93,
      "y" : 65
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 203,
          "y" : 64
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 203,
          "y" : 64
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 106849,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 106865,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 106855,
    "reactomeId" : 10679284,
    "displayName" : "PRLR:JAK2",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 369,
      "y" : 27
    },
    "minX" : 321,
    "maxX" : 410,
    "minY" : 10,
    "maxY" : 54,
    "prop" : {
      "x" : 334,
      "y" : 16,
      "width" : 70,
      "height" : 22
    },
    "textPosition" : {
      "x" : 335,
      "y" : 17
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 404,
          "y" : 16
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 404,
          "y" : 16
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 106854,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 321,
            "y" : 42
          },
          "b" : {
            "x" : 333,
            "y" : 54
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 327,
            "y" : 48
          }
        }
      }
    } ]
  }, {
    "id" : 106857,
    "reactomeId" : 10680916,
    "displayName" : "PRLR ligands:p-S349- PRLR:JAK2 dimer",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 462,
      "y" : 605
    },
    "minX" : 399,
    "maxX" : 532,
    "minY" : 391,
    "maxY" : 637,
    "prop" : {
      "x" : 399,
      "y" : 573,
      "width" : 127,
      "height" : 64
    },
    "textPosition" : {
      "x" : 406,
      "y" : 588
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 526,
          "y" : 573
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 526,
          "y" : 573
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 106856,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 462,
          "y" : 570
        },
        "to" : {
          "x" : 466,
          "y" : 391
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 458,
          "y" : 563
        },
        "b" : {
          "x" : 462,
          "y" : 570
        },
        "c" : {
          "x" : 466,
          "y" : 563
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 466,
          "y" : 563
        }
      }
    } ]
  }, {
    "id" : 106858,
    "reactomeId" : 10666868,
    "displayName" : "BTRC:CUL1:RBX1:SKP1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 571,
      "y" : 260
    },
    "minX" : 466,
    "maxX" : 653,
    "minY" : 236,
    "maxY" : 391,
    "prop" : {
      "x" : 522,
      "y" : 242,
      "width" : 98,
      "height" : 36
    },
    "textPosition" : {
      "x" : 532,
      "y" : 243
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 620,
          "y" : 242
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 620,
          "y" : 242
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 106856,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 556,
          "y" : 281
        },
        "to" : {
          "x" : 466,
          "y" : 391
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 555,
          "y" : 289
        },
        "b" : {
          "x" : 556,
          "y" : 281
        },
        "c" : {
          "x" : 549,
          "y" : 284
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 549,
          "y" : 284
        }
      }
    }, {
      "edgeId" : 106859,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 623,
          "y" : 259
        },
        "to" : {
          "x" : 653,
          "y" : 259
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 106860,
    "reactomeId" : 10679297,
    "displayName" : "PRLR ligands:p-S349-PRLR:JAK2 dimer",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 565,
      "y" : 175
    },
    "minX" : 446,
    "maxX" : 653,
    "minY" : 144,
    "maxY" : 259,
    "prop" : {
      "x" : 498,
      "y" : 150,
      "width" : 134,
      "height" : 50
    },
    "textPosition" : {
      "x" : 511,
      "y" : 151
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 632,
          "y" : 150
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 632,
          "y" : 150
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 106859,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 591,
          "y" : 203
        },
        "to" : {
          "x" : 653,
          "y" : 259
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 106861,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 495,
          "y" : 175
        },
        "to" : {
          "x" : 446,
          "y" : 176
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 488,
          "y" : 179
        },
        "b" : {
          "x" : 495,
          "y" : 175
        },
        "c" : {
          "x" : 488,
          "y" : 171
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 488,
          "y" : 171
        }
      }
    } ]
  }, {
    "id" : 106863,
    "reactomeId" : 113592,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 346,
      "y" : 136
    },
    "minX" : 327,
    "maxX" : 387,
    "minY" : 120,
    "maxY" : 176,
    "prop" : {
      "x" : 327,
      "y" : 121,
      "width" : 39,
      "height" : 30
    },
    "textPosition" : {
      "x" : 331,
      "y" : 125
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 361,
          "y" : 126
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 361,
          "y" : 126
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 106861,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 361,
          "y" : 154
        },
        "to" : {
          "x" : 387,
          "y" : 176
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 368,
            "y" : 159
          },
          "b" : {
            "x" : 380,
            "y" : 171
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 374,
            "y" : 165
          }
        }
      }
    } ]
  }, {
    "id" : 106862,
    "reactomeId" : 10679288,
    "displayName" : "PRLR ligands:PRLR:JAK2 dimer",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 146,
      "y" : 179
    },
    "minX" : 88,
    "maxX" : 387,
    "minY" : 147,
    "maxY" : 205,
    "prop" : {
      "x" : 88,
      "y" : 153,
      "width" : 116,
      "height" : 52
    },
    "textPosition" : {
      "x" : 92,
      "y" : 170
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 204,
          "y" : 153
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 204,
          "y" : 153
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 106865,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 106861,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 207,
          "y" : 178
        },
        "to" : {
          "x" : 387,
          "y" : 176
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 106864,
    "reactomeId" : 29370,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 469,
      "y" : 130
    },
    "minX" : 446,
    "maxX" : 491,
    "minY" : 114,
    "maxY" : 176,
    "prop" : {
      "x" : 449,
      "y" : 115,
      "width" : 41,
      "height" : 30
    },
    "textPosition" : {
      "x" : 453,
      "y" : 119
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 485,
          "y" : 120
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 485,
          "y" : 120
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 106861,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 461,
          "y" : 148
        },
        "to" : {
          "x" : 446,
          "y" : 176
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 447,
            "y" : 156
          },
          "b" : {
            "x" : 459,
            "y" : 168
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 453,
            "y" : 162
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 461,
          "y" : 156
        },
        "b" : {
          "x" : 461,
          "y" : 148
        },
        "c" : {
          "x" : 454,
          "y" : 152
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 454,
          "y" : 152
        }
      }
    } ]
  }, {
    "id" : 106867,
    "reactomeId" : 113592,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 294,
      "y" : 390
    },
    "minX" : 243,
    "maxX" : 315,
    "minY" : 374,
    "maxY" : 424,
    "prop" : {
      "x" : 274,
      "y" : 375,
      "width" : 40,
      "height" : 30
    },
    "textPosition" : {
      "x" : 278,
      "y" : 379
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 309,
          "y" : 380
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 309,
          "y" : 380
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 106866,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 271,
          "y" : 403
        },
        "to" : {
          "x" : 243,
          "y" : 424
        }
      } ],
      "stoichiometry" : {
        "value" : 4,
        "shape" : {
          "a" : {
            "x" : 251,
            "y" : 407
          },
          "b" : {
            "x" : 263,
            "y" : 419
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 257,
            "y" : 413
          }
        }
      }
    } ]
  }, {
    "id" : 106869,
    "reactomeId" : 10679517,
    "displayName" : "PRLR ligands:Activated PRLR:p-Y1007-JAK2 dimer",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 100,
      "y" : 531
    },
    "minX" : 0,
    "maxX" : 243,
    "minY" : 482,
    "maxY" : 554,
    "prop" : {
      "x" : 0,
      "y" : 509,
      "width" : 201,
      "height" : 45
    },
    "textPosition" : {
      "x" : 1,
      "y" : 514
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 201,
          "y" : 509
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 201,
          "y" : 509
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 106866,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 165,
          "y" : 503
        },
        "to" : {
          "x" : 243,
          "y" : 482
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 171,
          "y" : 497
        },
        "b" : {
          "x" : 165,
          "y" : 503
        },
        "c" : {
          "x" : 173,
          "y" : 505
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 173,
          "y" : 505
        }
      }
    } ]
  }, {
    "id" : 106868,
    "reactomeId" : 10679288,
    "displayName" : "PRLR ligands:PRLR:JAK2 dimer",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 148,
      "y" : 357
    },
    "minX" : 88,
    "maxX" : 243,
    "minY" : 326,
    "maxY" : 424,
    "prop" : {
      "x" : 88,
      "y" : 332,
      "width" : 120,
      "height" : 50
    },
    "textPosition" : {
      "x" : 94,
      "y" : 339
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 208,
          "y" : 332
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 208,
          "y" : 332
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 106866,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 183,
          "y" : 388
        },
        "to" : {
          "x" : 243,
          "y" : 424
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 106871,
    "reactomeId" : 10679521,
    "displayName" : "PRLR ligands:Activated PRLR:JAK2 dimer:SH2B1 beta",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 117,
      "y" : 461
    },
    "minX" : 52,
    "maxX" : 234,
    "minY" : 430,
    "maxY" : 486,
    "prop" : {
      "x" : 52,
      "y" : 436,
      "width" : 131,
      "height" : 50
    },
    "textPosition" : {
      "x" : 51,
      "y" : 437
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 183,
          "y" : 436
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 183,
          "y" : 436
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 106866,
      "type" : "ACTIVATOR",
      "segments" : [ {
        "from" : {
          "x" : 186,
          "y" : 458
        },
        "to" : {
          "x" : 234,
          "y" : 457
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 227,
          "y" : 461
        },
        "b" : {
          "x" : 234,
          "y" : 457
        },
        "c" : {
          "x" : 227,
          "y" : 453
        },
        "type" : "ARROW",
        "empty" : true,
        "centre" : {
          "x" : 227,
          "y" : 453
        }
      }
    } ]
  }, {
    "id" : 106870,
    "reactomeId" : 29370,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 295,
      "y" : 518
    },
    "minX" : 243,
    "maxX" : 317,
    "minY" : 482,
    "maxY" : 533,
    "prop" : {
      "x" : 274,
      "y" : 503,
      "width" : 42,
      "height" : 30
    },
    "textPosition" : {
      "x" : 278,
      "y" : 507
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 311,
          "y" : 508
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 311,
          "y" : 508
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 106866,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 271,
          "y" : 503
        },
        "to" : {
          "x" : 243,
          "y" : 482
        }
      } ],
      "stoichiometry" : {
        "value" : 4,
        "shape" : {
          "a" : {
            "x" : 251,
            "y" : 486
          },
          "b" : {
            "x" : 263,
            "y" : 498
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 257,
            "y" : 492
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 263,
          "y" : 502
        },
        "b" : {
          "x" : 271,
          "y" : 503
        },
        "c" : {
          "x" : 268,
          "y" : 496
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 268,
          "y" : 496
        }
      }
    } ]
  } ],
  "edges" : [ {
    "id" : 106849,
    "reactomeId" : 10679301,
    "displayName" : "Prolactin receptor ligands bind the prolactin receptor",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 249,
      "y" : 79
    },
    "minX" : 206,
    "maxX" : 255,
    "minY" : 60,
    "maxY" : 85,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 223,
        "y" : 60
      },
      "to" : {
        "x" : 249,
        "y" : 79
      }
    }, {
      "from" : {
        "x" : 249,
        "y" : 79
      },
      "to" : {
        "x" : 206,
        "y" : 80
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 213,
        "y" : 76
      },
      "b" : {
        "x" : 206,
        "y" : 80
      },
      "c" : {
        "x" : 213,
        "y" : 84
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 213,
        "y" : 84
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 249,
        "y" : 79
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 249,
        "y" : 79
      }
    },
    "inputs" : [ {
      "id" : 106850,
      "points" : [ {
        "x" : 181,
        "y" : 48
      } ]
    }, {
      "id" : 106851,
      "points" : [ {
        "x" : 235,
        "y" : 46
      } ]
    } ],
    "outputs" : [ {
      "id" : 106852
    } ],
    "inhibitors" : [ {
      "id" : 106853,
      "points" : [ {
        "x" : 541,
        "y" : 352
      } ]
    } ]
  }, {
    "id" : 106865,
    "reactomeId" : 10684766,
    "displayName" : "PRLR activation",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 145,
      "y" : 127
    },
    "minX" : 139,
    "maxX" : 151,
    "minY" : 103,
    "maxY" : 150,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 145,
        "y" : 103
      },
      "to" : {
        "x" : 145,
        "y" : 127
      }
    }, {
      "from" : {
        "x" : 145,
        "y" : 127
      },
      "to" : {
        "x" : 145,
        "y" : 150
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 141,
        "y" : 143
      },
      "b" : {
        "x" : 145,
        "y" : 150
      },
      "c" : {
        "x" : 149,
        "y" : 143
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 149,
        "y" : 143
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 139,
        "y" : 121
      },
      "b" : {
        "x" : 151,
        "y" : 133
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 145,
        "y" : 127
      }
    },
    "inputs" : [ {
      "id" : 106852
    } ],
    "outputs" : [ {
      "id" : 106862
    } ]
  }, {
    "id" : 106866,
    "reactomeId" : 10679523,
    "displayName" : "JAK2 phosphorylation",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 243,
      "y" : 457
    },
    "minX" : 237,
    "maxX" : 249,
    "minY" : 424,
    "maxY" : 482,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 243,
        "y" : 424
      },
      "to" : {
        "x" : 243,
        "y" : 457
      }
    }, {
      "from" : {
        "x" : 243,
        "y" : 457
      },
      "to" : {
        "x" : 243,
        "y" : 482
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 237,
        "y" : 451
      },
      "b" : {
        "x" : 249,
        "y" : 463
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 243,
        "y" : 457
      }
    },
    "inputs" : [ {
      "id" : 106867,
      "points" : [ {
        "x" : 271,
        "y" : 403
      } ],
      "stoichiometry" : 4
    }, {
      "id" : 106868,
      "points" : [ {
        "x" : 183,
        "y" : 388
      } ]
    } ],
    "outputs" : [ {
      "id" : 106869,
      "points" : [ {
        "x" : 165,
        "y" : 503
      } ]
    }, {
      "id" : 106870,
      "points" : [ {
        "x" : 271,
        "y" : 503
      } ],
      "stoichiometry" : 4
    } ],
    "activators" : [ {
      "id" : 106871,
      "points" : [ {
        "x" : 186,
        "y" : 458
      } ]
    } ]
  }, {
    "id" : 106854,
    "reactomeId" : 10682248,
    "displayName" : "PRLR:JAK2 dimerizes",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 309,
      "y" : 55
    },
    "minX" : 286,
    "maxX" : 345,
    "minY" : 41,
    "maxY" : 61,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 345,
        "y" : 41
      },
      "to" : {
        "x" : 309,
        "y" : 55
      }
    }, {
      "from" : {
        "x" : 309,
        "y" : 55
      },
      "to" : {
        "x" : 286,
        "y" : 41
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 294,
        "y" : 41
      },
      "b" : {
        "x" : 286,
        "y" : 41
      },
      "c" : {
        "x" : 290,
        "y" : 48
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 290,
        "y" : 48
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 309,
        "y" : 55
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 309,
        "y" : 55
      }
    },
    "inputs" : [ {
      "id" : 106855,
      "stoichiometry" : 2
    } ],
    "outputs" : [ {
      "id" : 106851
    } ]
  }, {
    "id" : 106856,
    "reactomeId" : 10680918,
    "displayName" : "Prolactin receptor is internalized",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 492,
      "y" : 391
    },
    "minX" : 466,
    "maxX" : 514,
    "minY" : 385,
    "maxY" : 397,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 514,
        "y" : 391
      },
      "to" : {
        "x" : 492,
        "y" : 391
      }
    }, {
      "from" : {
        "x" : 492,
        "y" : 391
      },
      "to" : {
        "x" : 466,
        "y" : 391
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 486,
        "y" : 385
      },
      "b" : {
        "x" : 498,
        "y" : 397
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 492,
        "y" : 391
      }
    },
    "inputs" : [ {
      "id" : 106853
    } ],
    "outputs" : [ {
      "id" : 106857,
      "points" : [ {
        "x" : 462,
        "y" : 570
      } ]
    }, {
      "id" : 106858,
      "points" : [ {
        "x" : 556,
        "y" : 281
      } ]
    } ]
  }, {
    "id" : 106859,
    "reactomeId" : 10682257,
    "displayName" : "PRLR binds SCF beta-TrCP complex",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 654,
      "y" : 300
    },
    "minX" : 610,
    "maxX" : 660,
    "minY" : 259,
    "maxY" : 352,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 653,
        "y" : 259
      },
      "to" : {
        "x" : 654,
        "y" : 300
      }
    }, {
      "from" : {
        "x" : 654,
        "y" : 300
      },
      "to" : {
        "x" : 610,
        "y" : 352
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 611,
        "y" : 344
      },
      "b" : {
        "x" : 610,
        "y" : 352
      },
      "c" : {
        "x" : 618,
        "y" : 349
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 618,
        "y" : 349
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 654,
        "y" : 300
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 654,
        "y" : 300
      }
    },
    "inputs" : [ {
      "id" : 106858,
      "points" : [ {
        "x" : 623,
        "y" : 259
      } ]
    }, {
      "id" : 106860,
      "points" : [ {
        "x" : 591,
        "y" : 203
      } ]
    } ],
    "outputs" : [ {
      "id" : 106853
    } ]
  }, {
    "id" : 106861,
    "reactomeId" : 10682259,
    "displayName" : "PRLR is phosphorylated at Ser-349",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 415,
      "y" : 176
    },
    "minX" : 387,
    "maxX" : 446,
    "minY" : 170,
    "maxY" : 182,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 387,
        "y" : 176
      },
      "to" : {
        "x" : 415,
        "y" : 176
      }
    }, {
      "from" : {
        "x" : 415,
        "y" : 176
      },
      "to" : {
        "x" : 446,
        "y" : 176
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 409,
        "y" : 170
      },
      "b" : {
        "x" : 421,
        "y" : 182
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 415,
        "y" : 176
      }
    },
    "inputs" : [ {
      "id" : 106862,
      "points" : [ {
        "x" : 207,
        "y" : 178
      } ]
    }, {
      "id" : 106863,
      "points" : [ {
        "x" : 361,
        "y" : 154
      } ],
      "stoichiometry" : 2
    } ],
    "outputs" : [ {
      "id" : 106864,
      "points" : [ {
        "x" : 461,
        "y" : 148
      } ],
      "stoichiometry" : 2
    }, {
      "id" : 106860,
      "points" : [ {
        "x" : 495,
        "y" : 175
      } ]
    } ]
  } ],
  "compartments" : [ {
    "id" : 106872,
    "reactomeId" : 70101,
    "displayName" : "cytosol",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 361,
      "y" : 536
    },
    "minX" : 130,
    "maxX" : 593,
    "minY" : 22,
    "maxY" : 1050,
    "prop" : {
      "x" : 130,
      "y" : 22,
      "width" : 463,
      "height" : 1028
    },
    "textPosition" : {
      "x" : 333,
      "y" : 907
    },
    "insets" : {
      "x" : 140,
      "y" : 32,
      "width" : 443,
      "height" : 1008
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 106853, 106868, 106869, 106856, 106854, 106862, 106849, 106852, 106880, 106850, 106871, 106878, 106855, 106851, 106885, 106858, 106861, 106863, 106864, 106860, 106865, 106866, 106867, 106870, 106886 ]
  }, {
    "id" : 106878,
    "reactomeId" : 171907,
    "displayName" : "endosome lumen",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 464,
      "y" : 617
    },
    "minX" : 379,
    "maxX" : 550,
    "minY" : 554,
    "maxY" : 681,
    "prop" : {
      "x" : 379,
      "y" : 554,
      "width" : 171,
      "height" : 127
    },
    "textPosition" : {
      "x" : 405,
      "y" : 631
    },
    "insets" : {
      "x" : 389,
      "y" : 564,
      "width" : 151,
      "height" : 107
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 106857 ]
  } ],
  "notes" : [ ],
  "links" : [ {
    "id" : 106885,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 115,
      "y" : 583
    },
    "minX" : 107,
    "maxX" : 124,
    "minY" : 560,
    "maxY" : 607,
    "segments" : [ {
      "from" : {
        "x" : 124,
        "y" : 607
      },
      "to" : {
        "x" : 107,
        "y" : 560
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 109,
        "y" : 577
      },
      "b" : {
        "x" : 121,
        "y" : 589
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 115,
        "y" : 583
      }
    },
    "inputs" : [ {
      "id" : 106880
    } ],
    "outputs" : [ {
      "id" : 106869
    } ]
  }, {
    "id" : 106886,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 146,
      "y" : 267
    },
    "minX" : 140,
    "maxX" : 152,
    "minY" : 208,
    "maxY" : 326,
    "segments" : [ {
      "from" : {
        "x" : 146,
        "y" : 208
      },
      "to" : {
        "x" : 147,
        "y" : 326
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 140,
        "y" : 261
      },
      "b" : {
        "x" : 152,
        "y" : 273
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 146,
        "y" : 267
      }
    },
    "inputs" : [ {
      "id" : 106862
    } ],
    "outputs" : [ {
      "id" : 106868
    } ]
  } ],
  "shadows" : [ ],
  "minX" : 0,
  "maxX" : 660,
  "minY" : 0,
  "maxY" : 1050,
  "disease" : false
}