{ "dbId" : 10559115, "stableId" : "R-SSC-9948299", "displayName" : "Ribosome-associated quality control", "nodes" : [ { "id" : 8513, "reactomeId" : 10555077, "displayName" : "NEMF:60S ribosomal subunit:peptidyl-tRNA with nascent peptide-Ala", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1034, "y" : 712 }, "minX" : 651, "maxX" : 1260, "minY" : 689, "maxY" : 837, "prop" : { "x" : 814, "y" : 695, "width" : 440, "height" : 35 }, "textPosition" : { "x" : 818, "y" : 709 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1254, "y" : 695 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1254, "y" : 695 } } }, "connectors" : [ { "edgeId" : 8512, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1024, "y" : 733 }, "to" : { "x" : 965, "y" : 837 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 8520, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1050, "y" : 733 }, "to" : { "x" : 1144, "y" : 827 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 8528, "type" : "INPUT", "segments" : [ { "from" : { "x" : 811, "y" : 711 }, "to" : { "x" : 651, "y" : 711 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 8514, "reactomeId" : 10555144, "displayName" : "NEDD8-K699-CUL2:ELOB:ELOC:RBX1:KLHDC10", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 855, "y" : 801 }, "minX" : 771, "maxX" : 975, "minY" : 775, "maxY" : 1020, "prop" : { "x" : 771, "y" : 781, "width" : 169, "height" : 40 }, "textPosition" : { "x" : 775, "y" : 786 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 940, "y" : 781 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 940, "y" : 781 } } }, "connectors" : [ { "edgeId" : 8512, "type" : "INPUT", "segments" : [ { "from" : { "x" : 916, "y" : 824 }, "to" : { "x" : 965, "y" : 837 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 8516, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 855, "y" : 824 }, "to" : { "x" : 860, "y" : 1020 } }, { "from" : { "x" : 860, "y" : 1020 }, "to" : { "x" : 975, "y" : 1016 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 859, "y" : 831 }, "b" : { "x" : 855, "y" : 824 }, "c" : { "x" : 851, "y" : 831 }, "type" : "ARROW", "centre" : { "x" : 851, "y" : 831 } } } ] }, { "id" : 8515, "reactomeId" : 10555148, "displayName" : "NEDD8-K699-CUL2:ELOB:ELOC:RBX1:KLHDC10:nascent peptide-Alanine", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 967, "y" : 912 }, "minX" : 882, "maxX" : 1058, "minY" : 878, "maxY" : 980, "prop" : { "x" : 882, "y" : 884, "width" : 170, "height" : 57 }, "textPosition" : { "x" : 886, "y" : 892 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1052, "y" : 884 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1052, "y" : 884 } } }, "connectors" : [ { "edgeId" : 8512, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 8516, "type" : "INPUT", "segments" : [ { "from" : { "x" : 962, "y" : 944 }, "to" : { "x" : 971, "y" : 964 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 8516, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 969, "y" : 944 }, "to" : { "x" : 972, "y" : 972 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 972, "y" : 976 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 972, "y" : 976 } } } ] }, { "id" : 8517, "reactomeId" : 10550384, "displayName" : "Ub:UBE2D2", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1062, "y" : 987 }, "minX" : 971, "maxX" : 1138, "minY" : 952, "maxY" : 999, "prop" : { "x" : 1012, "y" : 975, "width" : 100, "height" : 24 }, "textPosition" : { "x" : 1022, "y" : 978 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1112, "y" : 975 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1112, "y" : 975 } } }, "connectors" : [ { "edgeId" : 8516, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1014, "y" : 972 }, "to" : { "x" : 971, "y" : 964 } } ], "stoichiometry" : { "value" : 3, "shape" : { "a" : { "x" : 986, "y" : 962 }, "b" : { "x" : 998, "y" : 974 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 992, "y" : 968 } } } }, { "edgeId" : 8524, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1088, "y" : 972 }, "to" : { "x" : 1138, "y" : 952 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 1107, "y" : 956 }, "b" : { "x" : 1119, "y" : 968 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1113, "y" : 962 } } } } ] }, { "id" : 8518, "reactomeId" : 10459548, "displayName" : "UBE2D2", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1065, "y" : 1024 }, "minX" : 975, "maxX" : 1140, "minY" : 1004, "maxY" : 1038, "prop" : { "x" : 1032, "y" : 1010, "width" : 66, "height" : 28 }, "textPosition" : { "x" : 1036, "y" : 1013 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1098, "y" : 1010 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1098, "y" : 1010 } } }, "connectors" : [ { "edgeId" : 8516, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1029, "y" : 1021 }, "to" : { "x" : 975, "y" : 1016 } } ], "stoichiometry" : { "value" : 3, "shape" : { "a" : { "x" : 996, "y" : 1012 }, "b" : { "x" : 1008, "y" : 1024 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1002, "y" : 1018 } } }, "endShape" : { "a" : { "x" : 1022, "y" : 1024 }, "b" : { "x" : 1029, "y" : 1021 }, "c" : { "x" : 1022, "y" : 1016 }, "type" : "ARROW", "centre" : { "x" : 1022, "y" : 1016 } } }, { "edgeId" : 8524, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1101, "y" : 1020 }, "to" : { "x" : 1140, "y" : 1015 } } ], "stoichiometry" : { "value" : 3, "shape" : { "a" : { "x" : 1114, "y" : 1011 }, "b" : { "x" : 1126, "y" : 1023 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1120, "y" : 1017 } } }, "endShape" : { "a" : { "x" : 1107, "y" : 1015 }, "b" : { "x" : 1101, "y" : 1020 }, "c" : { "x" : 1108, "y" : 1023 }, "type" : "ARROW", "centre" : { "x" : 1108, "y" : 1023 } } } ] }, { "id" : 8519, "reactomeId" : 10555150, "displayName" : "K48polyUb-nascent peptide-Alanine", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1069, "y" : 1090 }, "minX" : 949, "maxX" : 1195, "minY" : 1015, "maxY" : 1104, "prop" : { "x" : 949, "y" : 1077, "width" : 240, "height" : 27 }, "textPosition" : { "x" : 954, "y" : 1083 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1189, "y" : 1077 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1189, "y" : 1077 } } }, "connectors" : [ { "edgeId" : 8516, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1051, "y" : 1074 }, "to" : { "x" : 975, "y" : 1016 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1043, "y" : 1073 }, "b" : { "x" : 1051, "y" : 1074 }, "c" : { "x" : 1048, "y" : 1067 }, "type" : "ARROW", "centre" : { "x" : 1048, "y" : 1067 } } }, { "edgeId" : 8524, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1081, "y" : 1074 }, "to" : { "x" : 1140, "y" : 1015 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1083, "y" : 1066 }, "b" : { "x" : 1081, "y" : 1074 }, "c" : { "x" : 1089, "y" : 1072 }, "type" : "ARROW", "centre" : { "x" : 1089, "y" : 1072 } } }, { "edgeId" : 8525, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 8521, "reactomeId" : 10487116, "displayName" : "RCHY1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1243, "y" : 823 }, "minX" : 1140, "maxX" : 1283, "minY" : 804, "maxY" : 1015, "prop" : { "x" : 1210, "y" : 810, "width" : 67, "height" : 26 }, "textPosition" : { "x" : 1219, "y" : 812 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1277, "y" : 810 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1277, "y" : 810 } } }, "connectors" : [ { "edgeId" : 8520, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1207, "y" : 824 }, "to" : { "x" : 1144, "y" : 827 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 8524, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1243, "y" : 839 }, "to" : { "x" : 1244, "y" : 1014 } }, { "from" : { "x" : 1244, "y" : 1014 }, "to" : { "x" : 1140, "y" : 1015 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1247, "y" : 846 }, "b" : { "x" : 1243, "y" : 839 }, "c" : { "x" : 1239, "y" : 846 }, "type" : "ARROW", "centre" : { "x" : 1239, "y" : 846 } } } ] }, { "id" : 8522, "reactomeId" : 10550384, "displayName" : "Ub:UBE2D2", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1194, "y" : 787 }, "minX" : 1144, "maxX" : 1251, "minY" : 767, "maxY" : 827, "prop" : { "x" : 1144, "y" : 773, "width" : 101, "height" : 28 }, "textPosition" : { "x" : 1155, "y" : 780 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1245, "y" : 773 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1245, "y" : 773 } } }, "connectors" : [ { "edgeId" : 8520, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1176, "y" : 804 }, "to" : { "x" : 1144, "y" : 827 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 8523, "reactomeId" : 10555157, "displayName" : "RCHY1:Ub:UBE2D2:nascent peptide-Ala", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1148, "y" : 911 }, "minX" : 1071, "maxX" : 1231, "minY" : 886, "maxY" : 972, "prop" : { "x" : 1071, "y" : 892, "width" : 154, "height" : 39 }, "textPosition" : { "x" : 1081, "y" : 896 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1225, "y" : 892 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1225, "y" : 892 } } }, "connectors" : [ { "edgeId" : 8520, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 8524, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1143, "y" : 934 }, "to" : { "x" : 1138, "y" : 952 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 8524, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1145, "y" : 934 }, "to" : { "x" : 1141, "y" : 964 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1141, "y" : 968 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1141, "y" : 968 } } } ] }, { "id" : 8526, "reactomeId" : 10447615, "displayName" : "Ub", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1071, "y" : 1220 }, "minX" : 1056, "maxX" : 1087, "minY" : 1159, "maxY" : 1232, "prop" : { "x" : 1056, "y" : 1208, "width" : 31, "height" : 24 }, "textPosition" : { "x" : 1059, "y" : 1209 }, "connectors" : [ { "edgeId" : 8525, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 3, "shape" : { "a" : { "x" : 1063, "y" : 1159 }, "b" : { "x" : 1075, "y" : 1171 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1069, "y" : 1165 } } } } ] }, { "id" : 8527, "reactomeId" : 10447709, "displayName" : "26S proteasome", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1133, "y" : 1267 }, "minX" : 1071, "maxX" : 1201, "minY" : 1125, "maxY" : 1280, "prop" : { "x" : 1071, "y" : 1255, "width" : 124, "height" : 25 }, "textPosition" : { "x" : 1077, "y" : 1259 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1195, "y" : 1255 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1195, "y" : 1255 } } }, "connectors" : [ { "edgeId" : 8525, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1132, "y" : 1252 }, "to" : { "x" : 1132, "y" : 1127 } }, { "from" : { "x" : 1132, "y" : 1127 }, "to" : { "x" : 1085, "y" : 1128 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1081, "y" : 1129 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1081, "y" : 1129 } } } ] }, { "id" : 8529, "reactomeId" : 10487300, "displayName" : "LTN1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 676, "y" : 769 }, "minX" : 647, "maxX" : 711, "minY" : 711, "maxY" : 781, "prop" : { "x" : 647, "y" : 758, "width" : 58, "height" : 23 }, "textPosition" : { "x" : 657, "y" : 759 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 705, "y" : 758 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 705, "y" : 758 } } }, "connectors" : [ { "edgeId" : 8528, "type" : "INPUT", "segments" : [ { "from" : { "x" : 671, "y" : 755 }, "to" : { "x" : 651, "y" : 711 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 8530, "reactomeId" : 10555069, "displayName" : "TCF25", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 631, "y" : 806 }, "minX" : 602, "maxX" : 666, "minY" : 711, "maxY" : 819, "prop" : { "x" : 602, "y" : 793, "width" : 58, "height" : 26 }, "textPosition" : { "x" : 608, "y" : 795 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 660, "y" : 793 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 660, "y" : 793 } } }, "connectors" : [ { "edgeId" : 8528, "type" : "INPUT", "segments" : [ { "from" : { "x" : 633, "y" : 790 }, "to" : { "x" : 651, "y" : 711 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 8531, "reactomeId" : 10555079, "displayName" : "LTN1:TCF25:NEMF:60S ribosomal subunit:peptidyl-tRNA with nascent peptide-Ala", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 370, "y" : 718 }, "minX" : 238, "maxX" : 509, "minY" : 693, "maxY" : 775, "prop" : { "x" : 238, "y" : 699, "width" : 265, "height" : 39 }, "textPosition" : { "x" : 255, "y" : 689 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 503, "y" : 699 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 503, "y" : 699 } } }, "connectors" : [ { "edgeId" : 8528, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 8532, "type" : "INPUT", "segments" : [ { "from" : { "x" : 304, "y" : 741 }, "to" : { "x" : 253, "y" : 753 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 8532, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 330, "y" : 741 }, "to" : { "x" : 268, "y" : 769 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 264, "y" : 771 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 264, "y" : 771 } } } ] }, { "id" : 8533, "reactomeId" : 10550346, "displayName" : "Ub:UBE2D1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 160, "y" : 708 }, "minX" : 116, "maxX" : 253, "minY" : 688, "maxY" : 753, "prop" : { "x" : 116, "y" : 694, "width" : 89, "height" : 28 }, "textPosition" : { "x" : 121, "y" : 701 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 205, "y" : 694 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 205, "y" : 694 } } }, "connectors" : [ { "edgeId" : 8532, "type" : "INPUT", "segments" : [ { "from" : { "x" : 188, "y" : 725 }, "to" : { "x" : 253, "y" : 753 } } ], "stoichiometry" : { "value" : 3, "shape" : { "a" : { "x" : 214, "y" : 733 }, "b" : { "x" : 226, "y" : 745 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 220, "y" : 739 } } } } ] }, { "id" : 8534, "reactomeId" : 10447778, "displayName" : "UBE2D1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 153, "y" : 811 }, "minX" : 123, "maxX" : 252, "minY" : 791, "maxY" : 825, "prop" : { "x" : 123, "y" : 797, "width" : 61, "height" : 28 }, "textPosition" : { "x" : 124, "y" : 800 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 184, "y" : 797 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 184, "y" : 797 } } }, "connectors" : [ { "edgeId" : 8532, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 187, "y" : 806 }, "to" : { "x" : 252, "y" : 796 } } ], "stoichiometry" : { "value" : 3, "shape" : { "a" : { "x" : 213, "y" : 795 }, "b" : { "x" : 225, "y" : 807 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 219, "y" : 801 } } }, "endShape" : { "a" : { "x" : 193, "y" : 801 }, "b" : { "x" : 187, "y" : 806 }, "c" : { "x" : 194, "y" : 809 }, "type" : "ARROW", "centre" : { "x" : 194, "y" : 809 } } } ] }, { "id" : 8535, "reactomeId" : 10555089, "displayName" : "LTN1:TCF25:NEMF:60S ribosomal subunit:peptidyl-tRNA with K48polyUb-nascent peptide-Ala", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 379, "y" : 841 }, "minX" : 222, "maxX" : 543, "minY" : 796, "maxY" : 862, "prop" : { "x" : 222, "y" : 821, "width" : 315, "height" : 41 }, "textPosition" : { "x" : 229, "y" : 813 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 537, "y" : 821 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 537, "y" : 821 } } }, "connectors" : [ { "edgeId" : 8532, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 321, "y" : 818 }, "to" : { "x" : 252, "y" : 796 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 313, "y" : 820 }, "b" : { "x" : 321, "y" : 818 }, "c" : { "x" : 316, "y" : 812 }, "type" : "ARROW", "centre" : { "x" : 316, "y" : 812 } } } ] }, { "id" : 8485, "reactomeId" : 10555058, "displayName" : "80S Ribosome:no-go mRNA:peptidyl-tRNA with elongating peptide", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 162, "y" : 45 }, "minX" : 51, "maxX" : 279, "minY" : 20, "maxY" : 111, "prop" : { "x" : 51, "y" : 26, "width" : 222, "height" : 38 }, "textPosition" : { "x" : 64, "y" : 15 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 273, "y" : 26 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 273, "y" : 26 } } }, "connectors" : [ { "edgeId" : 8484, "type" : "INPUT", "segments" : [ { "from" : { "x" : 165, "y" : 67 }, "to" : { "x" : 174, "y" : 111 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 8486, "reactomeId" : 10541394, "displayName" : "Ub:UBE2D1,2,3", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 281, "y" : 105 }, "minX" : 174, "maxX" : 340, "minY" : 85, "maxY" : 217, "prop" : { "x" : 229, "y" : 91, "width" : 105, "height" : 29 }, "textPosition" : { "x" : 230, "y" : 99 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 334, "y" : 91 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 334, "y" : 91 } } }, "connectors" : [ { "edgeId" : 8484, "type" : "INPUT", "segments" : [ { "from" : { "x" : 226, "y" : 107 }, "to" : { "x" : 174, "y" : 111 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 8489, "type" : "INPUT", "segments" : [ { "from" : { "x" : 281, "y" : 123 }, "to" : { "x" : 282, "y" : 217 } } ], "stoichiometry" : { "value" : 8, "shape" : { "a" : { "x" : 275, "y" : 164 }, "b" : { "x" : 287, "y" : 176 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 281, "y" : 170 } } } } ] }, { "id" : 8487, "reactomeId" : 10555056, "displayName" : "ZNF598", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 105, "y" : 109 }, "minX" : 73, "maxX" : 174, "minY" : 89, "maxY" : 123, "prop" : { "x" : 73, "y" : 95, "width" : 65, "height" : 28 }, "textPosition" : { "x" : 77, "y" : 98 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 138, "y" : 95 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 138, "y" : 95 } } }, "connectors" : [ { "edgeId" : 8484, "type" : "INPUT", "segments" : [ { "from" : { "x" : 141, "y" : 109 }, "to" : { "x" : 174, "y" : 111 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 8488, "reactomeId" : 10555060, "displayName" : "ZNF598:Ub:UBE2D1,2,3:80S Ribosome:mRNA:peptidyl-tRNA with nascent peptide", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 177, "y" : 193 }, "minX" : 99, "maxX" : 282, "minY" : 151, "maxY" : 239, "prop" : { "x" : 99, "y" : 157, "width" : 157, "height" : 73 }, "textPosition" : { "x" : 107, "y" : 167 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 256, "y" : 157 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 256, "y" : 157 } } }, "connectors" : [ { "edgeId" : 8484, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 8489, "type" : "INPUT", "segments" : [ { "from" : { "x" : 259, "y" : 210 }, "to" : { "x" : 282, "y" : 217 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 8489, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 259, "y" : 228 }, "to" : { "x" : 270, "y" : 234 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 273, "y" : 235 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 273, "y" : 235 } } } ] }, { "id" : 8490, "reactomeId" : 10459554, "displayName" : "UBE2D1,2,3", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 375, "y" : 277 }, "minX" : 305, "maxX" : 418, "minY" : 254, "maxY" : 291, "prop" : { "x" : 332, "y" : 263, "width" : 86, "height" : 28 }, "textPosition" : { "x" : 334, "y" : 266 }, "connectors" : [ { "edgeId" : 8489, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 326, "y" : 264 }, "to" : { "x" : 305, "y" : 257 } } ], "stoichiometry" : { "value" : 9, "shape" : { "a" : { "x" : 309, "y" : 254 }, "b" : { "x" : 321, "y" : 266 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 315, "y" : 260 } } }, "endShape" : { "a" : { "x" : 318, "y" : 266 }, "b" : { "x" : 326, "y" : 264 }, "c" : { "x" : 321, "y" : 258 }, "type" : "ARROW", "centre" : { "x" : 321, "y" : 258 } } } ] }, { "id" : 8491, "reactomeId" : 10555046, "displayName" : "K63polyUb-80S Ribosome:no-go mRNA:peptidyl-tRNA with elongating peptide", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 171, "y" : 283 }, "minX" : 79, "maxX" : 305, "minY" : 251, "maxY" : 352, "prop" : { "x" : 79, "y" : 257, "width" : 184, "height" : 52 }, "textPosition" : { "x" : 83, "y" : 260 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 263, "y" : 257 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 263, "y" : 257 } } }, "connectors" : [ { "edgeId" : 8489, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 266, "y" : 265 }, "to" : { "x" : 305, "y" : 257 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 272, "y" : 260 }, "b" : { "x" : 266, "y" : 265 }, "c" : { "x" : 274, "y" : 268 }, "type" : "ARROW", "centre" : { "x" : 274, "y" : 268 } } }, { "edgeId" : 8492, "type" : "INPUT", "segments" : [ { "from" : { "x" : 175, "y" : 312 }, "to" : { "x" : 182, "y" : 352 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 8493, "reactomeId" : 10555031, "displayName" : "RQT complex", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 327, "y" : 354 }, "minX" : 182, "maxX" : 388, "minY" : 337, "maxY" : 366, "prop" : { "x" : 273, "y" : 343, "width" : 109, "height" : 23 }, "textPosition" : { "x" : 284, "y" : 345 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 382, "y" : 343 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 382, "y" : 343 } } }, "connectors" : [ { "edgeId" : 8492, "type" : "INPUT", "segments" : [ { "from" : { "x" : 270, "y" : 353 }, "to" : { "x" : 182, "y" : 352 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 8494, "reactomeId" : 10555048, "displayName" : "RQT complex:K63polyUb-80S Ribosome:no-go mRNA:peptidyl tRNA with nascent peptide", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 186, "y" : 425 }, "minX" : 57, "maxX" : 322, "minY" : 398, "maxY" : 447, "prop" : { "x" : 57, "y" : 404, "width" : 259, "height" : 43 }, "textPosition" : { "x" : 57, "y" : 398 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 316, "y" : 404 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 316, "y" : 404 } } }, "connectors" : [ { "edgeId" : 8492, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 8496, "reactomeId" : 10555173, "displayName" : "PELO:HBS1L-1:GTP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 758, "y" : 79 }, "minX" : 683, "maxX" : 954, "minY" : 60, "maxY" : 107, "prop" : { "x" : 683, "y" : 66, "width" : 150, "height" : 26 }, "textPosition" : { "x" : 697, "y" : 71 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 833, "y" : 66 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 833, "y" : 66 } } }, "connectors" : [ { "edgeId" : 8495, "type" : "INPUT", "segments" : [ { "from" : { "x" : 836, "y" : 89 }, "to" : { "x" : 954, "y" : 107 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 8497, "reactomeId" : 10555165, "displayName" : "80S Ribosome:non-stop mRNA:peptidyl-tRNA with elongating peptide", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 988, "y" : 46 }, "minX" : 867, "maxX" : 1116, "minY" : 20, "maxY" : 107, "prop" : { "x" : 867, "y" : 26, "width" : 243, "height" : 41 }, "textPosition" : { "x" : 867, "y" : 32 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1110, "y" : 26 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1110, "y" : 26 } } }, "connectors" : [ { "edgeId" : 8495, "type" : "INPUT", "segments" : [ { "from" : { "x" : 976, "y" : 70 }, "to" : { "x" : 954, "y" : 107 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 8498, "reactomeId" : 10555175, "displayName" : "PELO:HBS1L-1:GTP:80S ribosome:non-stop mRNA:peptidyl-tRNA with nascent peptide", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 959, "y" : 182 }, "minX" : 854, "maxX" : 1071, "minY" : 147, "maxY" : 256, "prop" : { "x" : 854, "y" : 153, "width" : 211, "height" : 58 }, "textPosition" : { "x" : 870, "y" : 148 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1065, "y" : 153 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1065, "y" : 153 } } }, "connectors" : [ { "edgeId" : 8495, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 8499, "type" : "INPUT", "segments" : [ { "from" : { "x" : 955, "y" : 214 }, "to" : { "x" : 951, "y" : 240 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 8499, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 958, "y" : 214 }, "to" : { "x" : 957, "y" : 248 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 957, "y" : 252 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 957, "y" : 252 } } } ] }, { "id" : 8500, "reactomeId" : 10555182, "displayName" : "ABCE1:ATP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 843, "y" : 235 }, "minX" : 799, "maxX" : 951, "minY" : 217, "maxY" : 248, "prop" : { "x" : 799, "y" : 223, "width" : 88, "height" : 25 }, "textPosition" : { "x" : 805, "y" : 227 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 887, "y" : 223 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 887, "y" : 223 } } }, "connectors" : [ { "edgeId" : 8499, "type" : "INPUT", "segments" : [ { "from" : { "x" : 890, "y" : 237 }, "to" : { "x" : 951, "y" : 240 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 8501, "reactomeId" : 10555186, "displayName" : "HBS1L-1:GDP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1046, "y" : 294 }, "minX" : 958, "maxX" : 1103, "minY" : 275, "maxY" : 308, "prop" : { "x" : 996, "y" : 281, "width" : 101, "height" : 27 }, "textPosition" : { "x" : 1002, "y" : 287 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1097, "y" : 281 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1097, "y" : 281 } } }, "connectors" : [ { "edgeId" : 8499, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 993, "y" : 287 }, "to" : { "x" : 958, "y" : 283 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 986, "y" : 290 }, "b" : { "x" : 993, "y" : 287 }, "c" : { "x" : 987, "y" : 282 }, "type" : "ARROW", "centre" : { "x" : 987, "y" : 282 } } } ] }, { "id" : 8502, "reactomeId" : 10555184, "displayName" : "ABCE1:ATP:PELO:80S Ribosome:non-stop mRNA:peptidyl-tRNA with elongating peptide", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 960, "y" : 343 }, "minX" : 857, "maxX" : 1070, "minY" : 283, "maxY" : 402, "prop" : { "x" : 857, "y" : 317, "width" : 207, "height" : 53 }, "textPosition" : { "x" : 857, "y" : 321 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1064, "y" : 317 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1064, "y" : 317 } } }, "connectors" : [ { "edgeId" : 8499, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 959, "y" : 314 }, "to" : { "x" : 958, "y" : 283 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 955, "y" : 307 }, "b" : { "x" : 959, "y" : 314 }, "c" : { "x" : 963, "y" : 307 }, "type" : "ARROW", "centre" : { "x" : 963, "y" : 307 } } }, { "edgeId" : 8504, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 8504, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 960, "y" : 373 }, "to" : { "x" : 961, "y" : 394 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 961, "y" : 398 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 961, "y" : 398 } } } ] }, { "id" : 8503, "reactomeId" : 29372, "displayName" : "Pi", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 909, "y" : 291 }, "minX" : 890, "maxX" : 958, "minY" : 273, "maxY" : 308, "prop" : { "x" : 890, "y" : 274, "width" : 39, "height" : 34 }, "textPosition" : { "x" : 900, "y" : 280 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 924, "y" : 279 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 924, "y" : 279 } } }, "connectors" : [ { "edgeId" : 8499, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 932, "y" : 287 }, "to" : { "x" : 958, "y" : 283 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 938, "y" : 282 }, "b" : { "x" : 932, "y" : 287 }, "c" : { "x" : 939, "y" : 290 }, "type" : "ARROW", "centre" : { "x" : 939, "y" : 290 } } } ] }, { "id" : 8505, "reactomeId" : 10555169, "displayName" : "PELO", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1089, "y" : 409 }, "minX" : 963, "maxX" : 1126, "minY" : 389, "maxY" : 433, "prop" : { "x" : 1059, "y" : 395, "width" : 61, "height" : 28 }, "textPosition" : { "x" : 1070, "y" : 398 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1120, "y" : 395 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1120, "y" : 395 } } }, "connectors" : [ { "edgeId" : 8504, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1056, "y" : 414 }, "to" : { "x" : 963, "y" : 433 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1050, "y" : 419 }, "b" : { "x" : 1056, "y" : 414 }, "c" : { "x" : 1048, "y" : 411 }, "type" : "ARROW", "centre" : { "x" : 1048, "y" : 411 } } } ] }, { "id" : 8506, "reactomeId" : 10555210, "displayName" : "ABCE1:ADP:40S ribosomal subunit", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1015, "y" : 491 }, "minX" : 899, "maxX" : 1137, "minY" : 433, "maxY" : 505, "prop" : { "x" : 899, "y" : 478, "width" : 232, "height" : 27 }, "textPosition" : { "x" : 904, "y" : 484 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1131, "y" : 478 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1131, "y" : 478 } } }, "connectors" : [ { "edgeId" : 8504, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1002, "y" : 475 }, "to" : { "x" : 963, "y" : 433 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 994, "y" : 473 }, "b" : { "x" : 1002, "y" : 475 }, "c" : { "x" : 1000, "y" : 467 }, "type" : "ARROW", "centre" : { "x" : 1000, "y" : 467 } } } ] }, { "id" : 8507, "reactomeId" : 10555052, "displayName" : "60S ribosomal subunit:peptidyl-tRNA with nascent peptide", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 686, "y" : 512 }, "minX" : 499, "maxX" : 963, "minY" : 433, "maxY" : 559, "prop" : { "x" : 499, "y" : 496, "width" : 375, "height" : 32 }, "textPosition" : { "x" : 501, "y" : 507 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 874, "y" : 496 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 874, "y" : 496 } } }, "connectors" : [ { "edgeId" : 8504, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 742, "y" : 493 }, "to" : { "x" : 963, "y" : 433 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 748, "y" : 487 }, "b" : { "x" : 742, "y" : 493 }, "c" : { "x" : 750, "y" : 495 }, "type" : "ARROW", "centre" : { "x" : 750, "y" : 495 } } }, { "edgeId" : 8509, "type" : "INPUT", "segments" : [ { "from" : { "x" : 710, "y" : 531 }, "to" : { "x" : 757, "y" : 559 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 8508, "reactomeId" : 29372, "displayName" : "Pi", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1084, "y" : 454 }, "minX" : 963, "maxX" : 1105, "minY" : 433, "maxY" : 471, "prop" : { "x" : 1065, "y" : 437, "width" : 39, "height" : 34 }, "textPosition" : { "x" : 1075, "y" : 443 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1099, "y" : 442 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1099, "y" : 442 } } }, "connectors" : [ { "edgeId" : 8504, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1062, "y" : 450 }, "to" : { "x" : 963, "y" : 433 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 1006, "y" : 435 }, "b" : { "x" : 1018, "y" : 447 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1012, "y" : 441 } } }, "endShape" : { "a" : { "x" : 1054, "y" : 453 }, "b" : { "x" : 1062, "y" : 450 }, "c" : { "x" : 1056, "y" : 445 }, "type" : "ARROW", "centre" : { "x" : 1056, "y" : 445 } } } ] }, { "id" : 8510, "reactomeId" : 10555075, "displayName" : "NEMF", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 686, "y" : 575 }, "minX" : 656, "maxX" : 757, "minY" : 558, "maxY" : 587, "prop" : { "x" : 656, "y" : 564, "width" : 60, "height" : 23 }, "textPosition" : { "x" : 665, "y" : 565 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 716, "y" : 564 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 716, "y" : 564 } } }, "connectors" : [ { "edgeId" : 8509, "type" : "INPUT", "segments" : [ { "from" : { "x" : 719, "y" : 568 }, "to" : { "x" : 757, "y" : 559 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 8511, "reactomeId" : 10555083, "displayName" : "NEMF:60S ribosomal subunit:peptidyl-tRNA with nascent peptide", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1032, "y" : 560 }, "minX" : 827, "maxX" : 1243, "minY" : 538, "maxY" : 576, "prop" : { "x" : 827, "y" : 544, "width" : 410, "height" : 32 }, "textPosition" : { "x" : 827, "y" : 555 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1237, "y" : 544 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1237, "y" : 544 } } }, "connectors" : [ { "edgeId" : 8509, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] } ], "edges" : [ { "id" : 8512, "reactomeId" : 10555155, "displayName" : "NEDD8-K699-CUL2:ELOB:ELOC:RBX1:KLHDC10 binds alanine-tailed nascent peptide", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 965, "y" : 859 }, "minX" : 959, "maxX" : 971, "minY" : 837, "maxY" : 881, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 965, "y" : 837 }, "to" : { "x" : 965, "y" : 859 } }, { "from" : { "x" : 965, "y" : 859 }, "to" : { "x" : 965, "y" : 881 } } ], "endShape" : { "a" : { "x" : 961, "y" : 874 }, "b" : { "x" : 965, "y" : 881 }, "c" : { "x" : 969, "y" : 874 }, "type" : "ARROW", "centre" : { "x" : 969, "y" : 874 } }, "reactionShape" : { "a" : { "x" : 959, "y" : 853 }, "b" : { "x" : 971, "y" : 865 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 965, "y" : 859 } }, "inputs" : [ { "id" : 8513, "points" : [ { "x" : 1024, "y" : 733 } ] }, { "id" : 8514, "points" : [ { "x" : 916, "y" : 824 } ] } ], "outputs" : [ { "id" : 8515 } ] }, { "id" : 8516, "reactomeId" : 10555153, "displayName" : "NEDD8-K699-CUL2:ELOB:ELOC:RBX1:KLHDC10 K48 polyubiquitinates alanine-tailed nascent peptide", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 973, "y" : 988 }, "minX" : 967, "maxX" : 979, "minY" : 964, "maxY" : 1016, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 971, "y" : 964 }, "to" : { "x" : 973, "y" : 988 } }, { "from" : { "x" : 973, "y" : 988 }, "to" : { "x" : 975, "y" : 1016 } } ], "reactionShape" : { "a" : { "x" : 967, "y" : 982 }, "b" : { "x" : 979, "y" : 994 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 973, "y" : 988 } }, "inputs" : [ { "id" : 8517, "points" : [ { "x" : 1014, "y" : 972 } ], "stoichiometry" : 3 }, { "id" : 8515, "points" : [ { "x" : 962, "y" : 944 } ] } ], "outputs" : [ { "id" : 8518, "points" : [ { "x" : 1029, "y" : 1021 } ], "stoichiometry" : 3 }, { "id" : 8519, "points" : [ { "x" : 1051, "y" : 1074 } ] }, { "id" : 8514, "points" : [ { "x" : 855, "y" : 824 }, { "x" : 860, "y" : 1020 } ] } ], "catalysts" : [ { "id" : 8515, "points" : [ { "x" : 969, "y" : 944 } ] } ] }, { "id" : 8484, "reactomeId" : 10555065, "displayName" : "ZNF598 and Ub:UBE2D1,2,3 bind stalled 80S ribosome", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 176, "y" : 132 }, "minX" : 170, "maxX" : 182, "minY" : 111, "maxY" : 154, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 174, "y" : 111 }, "to" : { "x" : 176, "y" : 132 } }, { "from" : { "x" : 176, "y" : 132 }, "to" : { "x" : 176, "y" : 154 } } ], "endShape" : { "a" : { "x" : 172, "y" : 147 }, "b" : { "x" : 176, "y" : 154 }, "c" : { "x" : 180, "y" : 147 }, "type" : "ARROW", "centre" : { "x" : 180, "y" : 147 } }, "reactionShape" : { "c" : { "x" : 176, "y" : 132 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 176, "y" : 132 } }, "inputs" : [ { "id" : 8485, "points" : [ { "x" : 165, "y" : 67 } ] }, { "id" : 8486, "points" : [ { "x" : 226, "y" : 107 } ] }, { "id" : 8487, "points" : [ { "x" : 141, "y" : 109 } ] } ], "outputs" : [ { "id" : 8488 } ] }, { "id" : 8520, "reactomeId" : 10555159, "displayName" : "RCHY1 binds alanine-tailed nascent peptide and Ub:UBE2D2", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 1143, "y" : 859 }, "minX" : 1137, "maxX" : 1149, "minY" : 827, "maxY" : 889, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 1144, "y" : 827 }, "to" : { "x" : 1143, "y" : 859 } }, { "from" : { "x" : 1143, "y" : 859 }, "to" : { "x" : 1146, "y" : 889 } } ], "endShape" : { "a" : { "x" : 1141, "y" : 883 }, "b" : { "x" : 1146, "y" : 889 }, "c" : { "x" : 1149, "y" : 882 }, "type" : "ARROW", "centre" : { "x" : 1149, "y" : 882 } }, "reactionShape" : { "a" : { "x" : 1137, "y" : 853 }, "b" : { "x" : 1149, "y" : 865 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 1143, "y" : 859 } }, "inputs" : [ { "id" : 8513, "points" : [ { "x" : 1050, "y" : 733 } ] }, { "id" : 8521, "points" : [ { "x" : 1207, "y" : 824 } ] }, { "id" : 8522, "points" : [ { "x" : 1176, "y" : 804 } ] } ], "outputs" : [ { "id" : 8523 } ] }, { "id" : 8489, "reactomeId" : 10555063, "displayName" : "ZNF598 K63 polyubiquitinates RPS10 (eS10) and RPS20 (uS10) of the 40S ribosomal subunit", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 284, "y" : 241 }, "minX" : 278, "maxX" : 305, "minY" : 217, "maxY" : 257, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 282, "y" : 217 }, "to" : { "x" : 284, "y" : 241 } }, { "from" : { "x" : 284, "y" : 241 }, "to" : { "x" : 305, "y" : 257 } } ], "reactionShape" : { "a" : { "x" : 278, "y" : 235 }, "b" : { "x" : 290, "y" : 247 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 284, "y" : 241 } }, "inputs" : [ { "id" : 8486, "points" : [ { "x" : 281, "y" : 123 } ], "stoichiometry" : 8 }, { "id" : 8488, "points" : [ { "x" : 259, "y" : 210 } ] } ], "outputs" : [ { "id" : 8490, "points" : [ { "x" : 326, "y" : 264 } ], "stoichiometry" : 9 }, { "id" : 8491, "points" : [ { "x" : 266, "y" : 265 } ] } ], "catalysts" : [ { "id" : 8488, "points" : [ { "x" : 259, "y" : 228 } ] } ] }, { "id" : 8492, "reactomeId" : 10555050, "displayName" : "RQT complex binds K63polyUb-80S ribosome:no-go mRNA:peptidyl-tRNA with nascent peptide", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 183, "y" : 374 }, "minX" : 177, "maxX" : 189, "minY" : 352, "maxY" : 401, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 182, "y" : 352 }, "to" : { "x" : 183, "y" : 374 } }, { "from" : { "x" : 183, "y" : 374 }, "to" : { "x" : 184, "y" : 401 } } ], "endShape" : { "a" : { "x" : 180, "y" : 394 }, "b" : { "x" : 184, "y" : 401 }, "c" : { "x" : 188, "y" : 394 }, "type" : "ARROW", "centre" : { "x" : 188, "y" : 394 } }, "reactionShape" : { "c" : { "x" : 183, "y" : 374 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 183, "y" : 374 } }, "inputs" : [ { "id" : 8493, "points" : [ { "x" : 270, "y" : 353 } ] }, { "id" : 8491, "points" : [ { "x" : 175, "y" : 312 } ] } ], "outputs" : [ { "id" : 8494 } ] }, { "id" : 8524, "reactomeId" : 10555180, "displayName" : "RCHY1 K48 polyubiquitinates alanine-tailed nascent peptide", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1139, "y" : 980 }, "minX" : 1133, "maxX" : 1145, "minY" : 952, "maxY" : 1015, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1138, "y" : 952 }, "to" : { "x" : 1139, "y" : 980 } }, { "from" : { "x" : 1139, "y" : 980 }, "to" : { "x" : 1140, "y" : 1015 } } ], "reactionShape" : { "a" : { "x" : 1133, "y" : 974 }, "b" : { "x" : 1145, "y" : 986 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1139, "y" : 980 } }, "inputs" : [ { "id" : 8517, "points" : [ { "x" : 1088, "y" : 972 } ], "stoichiometry" : 2 }, { "id" : 8523, "points" : [ { "x" : 1143, "y" : 934 } ] } ], "outputs" : [ { "id" : 8518, "points" : [ { "x" : 1101, "y" : 1020 } ], "stoichiometry" : 3 }, { "id" : 8521, "points" : [ { "x" : 1243, "y" : 839 }, { "x" : 1244, "y" : 1014 } ] }, { "id" : 8519, "points" : [ { "x" : 1081, "y" : 1074 } ] } ], "catalysts" : [ { "id" : 8523, "points" : [ { "x" : 1145, "y" : 934 } ] } ] }, { "id" : 8525, "reactomeId" : 10555161, "displayName" : "The proteasome degrades the K48-polyubiquitinated alanine-tailed nascent peptide", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 1069, "y" : 1129 }, "minX" : 1063, "maxX" : 1075, "minY" : 1107, "maxY" : 1202, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 1069, "y" : 1107 }, "to" : { "x" : 1069, "y" : 1129 } }, { "from" : { "x" : 1069, "y" : 1129 }, "to" : { "x" : 1070, "y" : 1202 } } ], "endShape" : { "a" : { "x" : 1066, "y" : 1195 }, "b" : { "x" : 1070, "y" : 1202 }, "c" : { "x" : 1074, "y" : 1195 }, "type" : "ARROW", "centre" : { "x" : 1074, "y" : 1195 } }, "reactionShape" : { "a" : { "x" : 1063, "y" : 1123 }, "b" : { "x" : 1075, "y" : 1135 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 1069, "y" : 1129 } }, "inputs" : [ { "id" : 8519 } ], "outputs" : [ { "id" : 8526, "stoichiometry" : 3 } ], "catalysts" : [ { "id" : 8527, "points" : [ { "x" : 1132, "y" : 1252 }, { "x" : 1132, "y" : 1127 } ] } ] }, { "id" : 8495, "reactomeId" : 10555177, "displayName" : "PELO:HBS1L-1:GTP binds 80S ribosome:non-stop mRNA:peptidyl-tRNA with nascent peptide", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 955, "y" : 128 }, "minX" : 949, "maxX" : 961, "minY" : 107, "maxY" : 150, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 954, "y" : 107 }, "to" : { "x" : 955, "y" : 128 } }, { "from" : { "x" : 955, "y" : 128 }, "to" : { "x" : 956, "y" : 150 } } ], "endShape" : { "a" : { "x" : 952, "y" : 143 }, "b" : { "x" : 956, "y" : 150 }, "c" : { "x" : 960, "y" : 143 }, "type" : "ARROW", "centre" : { "x" : 960, "y" : 143 } }, "reactionShape" : { "c" : { "x" : 955, "y" : 128 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 955, "y" : 128 } }, "inputs" : [ { "id" : 8496, "points" : [ { "x" : 836, "y" : 89 } ] }, { "id" : 8497, "points" : [ { "x" : 976, "y" : 70 } ] } ], "outputs" : [ { "id" : 8498 } ] }, { "id" : 8528, "reactomeId" : 10555081, "displayName" : "LTN1 and TCF25 bind NEMF:60S ribosomal subunit:peptidyl-tRNA with nascent peptide-Ala", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 551, "y" : 712 }, "minX" : 506, "maxX" : 651, "minY" : 706, "maxY" : 718, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 651, "y" : 711 }, "to" : { "x" : 551, "y" : 712 } }, { "from" : { "x" : 551, "y" : 712 }, "to" : { "x" : 506, "y" : 713 } } ], "endShape" : { "a" : { "x" : 513, "y" : 709 }, "b" : { "x" : 506, "y" : 713 }, "c" : { "x" : 513, "y" : 717 }, "type" : "ARROW", "centre" : { "x" : 513, "y" : 717 } }, "reactionShape" : { "c" : { "x" : 551, "y" : 712 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 551, "y" : 712 } }, "inputs" : [ { "id" : 8513, "points" : [ { "x" : 811, "y" : 711 } ] }, { "id" : 8529, "points" : [ { "x" : 671, "y" : 755 } ] }, { "id" : 8530, "points" : [ { "x" : 633, "y" : 790 } ] } ], "outputs" : [ { "id" : 8531 } ] }, { "id" : 8499, "reactomeId" : 10555189, "displayName" : "ABCE1:ATP binds PELO:HBS1L-1:GTP:80S ribosome:non-stop mRNA:peptidyl-tRNA with nascent peptide and HBS1L-1:GDP is released", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 957, "y" : 264 }, "minX" : 951, "maxX" : 963, "minY" : 240, "maxY" : 283, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 951, "y" : 240 }, "to" : { "x" : 957, "y" : 264 } }, { "from" : { "x" : 957, "y" : 264 }, "to" : { "x" : 958, "y" : 283 } } ], "reactionShape" : { "a" : { "x" : 951, "y" : 258 }, "b" : { "x" : 963, "y" : 270 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 957, "y" : 264 } }, "inputs" : [ { "id" : 8498, "points" : [ { "x" : 955, "y" : 214 } ] }, { "id" : 8500, "points" : [ { "x" : 890, "y" : 237 } ] } ], "outputs" : [ { "id" : 8501, "points" : [ { "x" : 993, "y" : 287 } ] }, { "id" : 8502, "points" : [ { "x" : 959, "y" : 314 } ] }, { "id" : 8503, "points" : [ { "x" : 932, "y" : 287 } ] } ], "catalysts" : [ { "id" : 8498, "points" : [ { "x" : 958, "y" : 214 } ] } ] }, { "id" : 8532, "reactomeId" : 10555092, "displayName" : "LTN1 K48 polyubiquitinates the nascent peptide in NEMF:60S ribosomal subunit:peptidyl-tRNA with nascent peptide", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 253, "y" : 776 }, "minX" : 247, "maxX" : 259, "minY" : 753, "maxY" : 796, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 253, "y" : 753 }, "to" : { "x" : 253, "y" : 776 } }, { "from" : { "x" : 253, "y" : 776 }, "to" : { "x" : 252, "y" : 796 } } ], "reactionShape" : { "a" : { "x" : 247, "y" : 770 }, "b" : { "x" : 259, "y" : 782 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 253, "y" : 776 } }, "inputs" : [ { "id" : 8533, "points" : [ { "x" : 188, "y" : 725 } ], "stoichiometry" : 3 }, { "id" : 8531, "points" : [ { "x" : 304, "y" : 741 } ] } ], "outputs" : [ { "id" : 8534, "points" : [ { "x" : 187, "y" : 806 } ], "stoichiometry" : 3 }, { "id" : 8535, "points" : [ { "x" : 321, "y" : 818 } ] } ], "catalysts" : [ { "id" : 8531, "points" : [ { "x" : 330, "y" : 741 } ] } ] }, { "id" : 8504, "reactomeId" : 10555213, "displayName" : "ABCE1:PELO:80S Ribosome:non-stop mRNA:peptidyl-tRNA with elongating peptide dissociates yielding ABCE1:40S ribosomal subunit, PELO, and 60S ribosomal subunit:peptidyl-tRNA with nascent peptide", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 962, "y" : 410 }, "minX" : 953, "maxX" : 968, "minY" : 373, "maxY" : 433, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 953, "y" : 373 }, "to" : { "x" : 962, "y" : 410 } }, { "from" : { "x" : 962, "y" : 410 }, "to" : { "x" : 963, "y" : 433 } } ], "reactionShape" : { "a" : { "x" : 956, "y" : 404 }, "b" : { "x" : 968, "y" : 416 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 962, "y" : 410 } }, "inputs" : [ { "id" : 8502 } ], "outputs" : [ { "id" : 8505, "points" : [ { "x" : 1056, "y" : 414 } ] }, { "id" : 8506, "points" : [ { "x" : 1002, "y" : 475 } ] }, { "id" : 8507, "points" : [ { "x" : 742, "y" : 493 } ] }, { "id" : 8508, "points" : [ { "x" : 1062, "y" : 450 } ], "stoichiometry" : 2 } ], "catalysts" : [ { "id" : 8502, "points" : [ { "x" : 960, "y" : 373 } ] } ] }, { "id" : 8509, "reactomeId" : 10555085, "displayName" : "NEMF binds 60S ribosomal subunit:peptidyl-tRNA with nascent peptide", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 788, "y" : 558 }, "minX" : 757, "maxX" : 824, "minY" : 552, "maxY" : 564, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 757, "y" : 559 }, "to" : { "x" : 788, "y" : 558 } }, { "from" : { "x" : 788, "y" : 558 }, "to" : { "x" : 824, "y" : 558 } } ], "endShape" : { "a" : { "x" : 817, "y" : 562 }, "b" : { "x" : 824, "y" : 558 }, "c" : { "x" : 817, "y" : 554 }, "type" : "ARROW", "centre" : { "x" : 817, "y" : 554 } }, "reactionShape" : { "c" : { "x" : 788, "y" : 558 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 788, "y" : 558 } }, "inputs" : [ { "id" : 8510, "points" : [ { "x" : 719, "y" : 568 } ] }, { "id" : 8507, "points" : [ { "x" : 710, "y" : 531 } ] } ], "outputs" : [ { "id" : 8511 } ] } ], "compartments" : [ { "id" : 8536, "reactomeId" : 70101, "displayName" : "cytosol", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 663, "y" : 676 }, "minX" : 0, "maxX" : 1327, "minY" : 0, "maxY" : 1353, "prop" : { "x" : 0, "y" : 0, "width" : 1327, "height" : 1353 }, "textPosition" : { "x" : 22, "y" : 1292 }, "insets" : { "x" : 10, "y" : 10, "width" : 1307, "height" : 1333 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 8484, 8485, 8486, 8487, 8488, 8489, 8491, 8490, 8492, 8493, 8494, 8507, 8495, 8496, 8497, 8498, 8499, 8500, 8501, 8502, 8503, 8504, 8505, 8506, 8508, 8509, 8510, 8511, 8513, 8512, 8514, 8515, 8516, 8517, 8518, 8519, 8520, 8521, 8523, 8522, 8524, 8525, 8526, 8527, 8528, 8529, 8530, 8531, 8532, 8533, 8534, 8535 ] } ], "notes" : [ ], "links" : [ ], "shadows" : [ { "id" : 8537, "reactomeId" : 10559113, "displayName" : "ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 234, "y" : 236 }, "minX" : 41, "maxX" : 428, "minY" : 16, "maxY" : 457, "prop" : { "x" : 41, "y" : 16, "width" : 387, "height" : 441 }, "points" : [ { "x" : 41, "y" : 16 }, { "x" : 428, "y" : 16 }, { "x" : 428, "y" : 457 }, { "x" : 41, "y" : 457 } ], "colour" : "#4684ee" }, { "id" : 8538, "reactomeId" : 10559117, "displayName" : "Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 696, "y" : 888 }, "minX" : 106, "maxX" : 1287, "minY" : 486, "maxY" : 1290, "prop" : { "x" : 106, "y" : 538, "width" : 1181, "height" : 752 }, "points" : [ { "x" : 106, "y" : 486 }, { "x" : 1287, "y" : 486 }, { "x" : 1287, "y" : 1290 }, { "x" : 106, "y" : 1290 } ], "colour" : "#dc3912" }, { "id" : 8539, "reactomeId" : 10559121, "displayName" : "PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 815, "y" : 277 }, "minX" : 489, "maxX" : 1141, "minY" : 16, "maxY" : 538, "prop" : { "x" : 489, "y" : 16, "width" : 652, "height" : 470 }, "points" : [ { "x" : 489, "y" : 16 }, { "x" : 1141, "y" : 16 }, { "x" : 1141, "y" : 538 }, { "x" : 489, "y" : 538 } ], "colour" : "#008000" } ], "minX" : 0, "maxX" : 1327, "minY" : 0, "maxY" : 1353, "disease" : false }