{
  "dbId" : 10558393,
  "stableId" : "R-SSC-8951664",
  "displayName" : "Neddylation",
  "nodes" : [ {
    "id" : 100357,
    "reactomeId" : 10521718,
    "displayName" : "UCHL3,SENP8:NEDD8(1-88)",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 117,
      "y" : 472
    },
    "minX" : 67,
    "maxX" : 218,
    "minY" : 434,
    "maxY" : 497,
    "prop" : {
      "x" : 67,
      "y" : 447,
      "width" : 101,
      "height" : 50
    },
    "textPosition" : {
      "x" : 69,
      "y" : 462
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 168,
          "y" : 447
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 168,
          "y" : 447
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 100355,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 171,
          "y" : 477
        },
        "to" : {
          "x" : 196,
          "y" : 480
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 100355,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 156,
          "y" : 444
        },
        "to" : {
          "x" : 177,
          "y" : 434
        }
      }, {
        "from" : {
          "x" : 177,
          "y" : 434
        },
        "to" : {
          "x" : 211,
          "y" : 467
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 214,
          "y" : 470
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 214,
          "y" : 470
        }
      }
    } ]
  }, {
    "id" : 100356,
    "reactomeId" : 29356,
    "displayName" : "H2O",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 131,
      "y" : 531
    },
    "minX" : 105,
    "maxX" : 196,
    "minY" : 480,
    "maxY" : 549,
    "prop" : {
      "x" : 105,
      "y" : 514,
      "width" : 53,
      "height" : 35
    },
    "textPosition" : {
      "x" : 114,
      "y" : 521
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 153,
          "y" : 519
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 153,
          "y" : 519
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 100355,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 153,
          "y" : 511
        },
        "to" : {
          "x" : 196,
          "y" : 480
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ],
    "trivial" : true
  }, {
    "id" : 100359,
    "reactomeId" : 10521724,
    "displayName" : "NEDD8",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 289,
      "y" : 527
    },
    "minX" : 237,
    "maxX" : 348,
    "minY" : 478,
    "maxY" : 545,
    "prop" : {
      "x" : 237,
      "y" : 509,
      "width" : 105,
      "height" : 36
    },
    "textPosition" : {
      "x" : 264,
      "y" : 516
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 342,
          "y" : 509
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 342,
          "y" : 509
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 100355,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 273,
          "y" : 506
        },
        "to" : {
          "x" : 247,
          "y" : 478
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 265,
          "y" : 504
        },
        "b" : {
          "x" : 273,
          "y" : 506
        },
        "c" : {
          "x" : 271,
          "y" : 498
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 271,
          "y" : 498
        }
      }
    } ]
  }, {
    "id" : 100358,
    "reactomeId" : 10521722,
    "displayName" : "UCHL3,SENP8:NEDD8",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 356,
      "y" : 478
    },
    "minX" : 247,
    "maxX" : 419,
    "minY" : 454,
    "maxY" : 496,
    "prop" : {
      "x" : 300,
      "y" : 460,
      "width" : 113,
      "height" : 36
    },
    "textPosition" : {
      "x" : 308,
      "y" : 461
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 413,
          "y" : 460
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 413,
          "y" : 460
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 100355,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 297,
          "y" : 478
        },
        "to" : {
          "x" : 247,
          "y" : 478
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 290,
          "y" : 482
        },
        "b" : {
          "x" : 297,
          "y" : 478
        },
        "c" : {
          "x" : 290,
          "y" : 474
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 290,
          "y" : 474
        }
      }
    }, {
      "edgeId" : 100360,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 100361,
    "reactomeId" : 10521714,
    "displayName" : "UCHL3,SENP8",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 491,
      "y" : 517
    },
    "minX" : 435,
    "maxX" : 548,
    "minY" : 485,
    "maxY" : 530,
    "prop" : {
      "x" : 435,
      "y" : 504,
      "width" : 113,
      "height" : 26
    },
    "textPosition" : {
      "x" : 445,
      "y" : 506
    },
    "connectors" : [ {
      "edgeId" : 100360,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 478,
          "y" : 498
        },
        "to" : {
          "x" : 461,
          "y" : 485
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 470,
          "y" : 497
        },
        "b" : {
          "x" : 478,
          "y" : 498
        },
        "c" : {
          "x" : 475,
          "y" : 491
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 475,
          "y" : 491
        }
      }
    } ]
  }, {
    "id" : 100362,
    "reactomeId" : 10521720,
    "displayName" : "NEDD8",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 513,
      "y" : 410
    },
    "minX" : 461,
    "maxX" : 2951,
    "minY" : 164,
    "maxY" : 667,
    "prop" : {
      "x" : 488,
      "y" : 399,
      "width" : 50,
      "height" : 22
    },
    "textPosition" : {
      "x" : 491,
      "y" : 393
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 538,
          "y" : 399
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 538,
          "y" : 399
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 100360,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 505,
          "y" : 424
        },
        "to" : {
          "x" : 461,
          "y" : 485
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 504,
          "y" : 432
        },
        "b" : {
          "x" : 505,
          "y" : 424
        },
        "c" : {
          "x" : 498,
          "y" : 427
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 498,
          "y" : 427
        }
      }
    }, {
      "edgeId" : 100385,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 536,
          "y" : 396
        },
        "to" : {
          "x" : 1008,
          "y" : 174
        }
      }, {
        "from" : {
          "x" : 1008,
          "y" : 174
        },
        "to" : {
          "x" : 2787,
          "y" : 164
        }
      }, {
        "from" : {
          "x" : 2787,
          "y" : 164
        },
        "to" : {
          "x" : 2951,
          "y" : 667
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 541,
          "y" : 389
        },
        "b" : {
          "x" : 536,
          "y" : 396
        },
        "c" : {
          "x" : 544,
          "y" : 397
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 544,
          "y" : 397
        }
      }
    } ]
  }, {
    "id" : 100365,
    "reactomeId" : 10509880,
    "displayName" : "UBE2M",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 885,
      "y" : 710
    },
    "minX" : 845,
    "maxX" : 2084,
    "minY" : 690,
    "maxY" : 1277,
    "prop" : {
      "x" : 845,
      "y" : 696,
      "width" : 81,
      "height" : 28
    },
    "textPosition" : {
      "x" : 860,
      "y" : 699
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 926,
          "y" : 696
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 926,
          "y" : 696
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 100363,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 929,
          "y" : 722
        },
        "to" : {
          "x" : 1453,
          "y" : 886
        }
      }, {
        "from" : {
          "x" : 1453,
          "y" : 886
        },
        "to" : {
          "x" : 2084,
          "y" : 878
        }
      }, {
        "from" : {
          "x" : 2084,
          "y" : 878
        },
        "to" : {
          "x" : 2084,
          "y" : 825
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 937,
          "y" : 720
        },
        "b" : {
          "x" : 929,
          "y" : 722
        },
        "c" : {
          "x" : 934,
          "y" : 728
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 934,
          "y" : 728
        }
      }
    }, {
      "edgeId" : 100397,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 899,
          "y" : 727
        },
        "to" : {
          "x" : 1460,
          "y" : 1277
        }
      }, {
        "from" : {
          "x" : 1460,
          "y" : 1277
        },
        "to" : {
          "x" : 2070,
          "y" : 1277
        }
      }, {
        "from" : {
          "x" : 2070,
          "y" : 1277
        },
        "to" : {
          "x" : 2063,
          "y" : 1204
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 907,
          "y" : 729
        },
        "b" : {
          "x" : 899,
          "y" : 727
        },
        "c" : {
          "x" : 901,
          "y" : 735
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 901,
          "y" : 735
        }
      }
    } ]
  }, {
    "id" : 100364,
    "reactomeId" : 10541073,
    "displayName" : "NEDD8-AcM-UBE2M:CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1883,
      "y" : 830
    },
    "minX" : 1804,
    "maxX" : 2045,
    "minY" : 781,
    "maxY" : 862,
    "prop" : {
      "x" : 1804,
      "y" : 798,
      "width" : 159,
      "height" : 64
    },
    "textPosition" : {
      "x" : 1804,
      "y" : 799
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1963,
          "y" : 798
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1963,
          "y" : 798
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 100363,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 100363,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 1966,
          "y" : 798
        },
        "to" : {
          "x" : 2006,
          "y" : 781
        }
      }, {
        "from" : {
          "x" : 2006,
          "y" : 781
        },
        "to" : {
          "x" : 2038,
          "y" : 814
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 2041,
          "y" : 816
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2041,
          "y" : 816
        }
      }
    } ]
  }, {
    "id" : 100366,
    "reactomeId" : 10541080,
    "displayName" : "NEDD8-CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2193,
      "y" : 824
    },
    "minX" : 2084,
    "maxX" : 2263,
    "minY" : 786,
    "maxY" : 856,
    "prop" : {
      "x" : 2130,
      "y" : 792,
      "width" : 127,
      "height" : 64
    },
    "textPosition" : {
      "x" : 2134,
      "y" : 793
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2257,
          "y" : 792
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2257,
          "y" : 792
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 100363,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 2127,
          "y" : 824
        },
        "to" : {
          "x" : 2084,
          "y" : 825
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 2120,
          "y" : 828
        },
        "b" : {
          "x" : 2127,
          "y" : 824
        },
        "c" : {
          "x" : 2120,
          "y" : 820
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 2120,
          "y" : 820
        }
      }
    } ]
  }, {
    "id" : 100369,
    "reactomeId" : 10541263,
    "displayName" : "NEDD8-CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1732,
      "y" : 1470
    },
    "minX" : 1586,
    "maxX" : 1813,
    "minY" : 1431,
    "maxY" : 1503,
    "prop" : {
      "x" : 1658,
      "y" : 1437,
      "width" : 149,
      "height" : 66
    },
    "textPosition" : {
      "x" : 1673,
      "y" : 1440
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1807,
          "y" : 1437
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1807,
          "y" : 1437
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 100367,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1655,
          "y" : 1471
        },
        "to" : {
          "x" : 1586,
          "y" : 1472
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1648,
          "y" : 1475
        },
        "b" : {
          "x" : 1655,
          "y" : 1471
        },
        "c" : {
          "x" : 1648,
          "y" : 1467
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1648,
          "y" : 1467
        }
      }
    }, {
      "edgeId" : 100389,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 100368,
    "reactomeId" : 10541249,
    "displayName" : "NEDD8-AcM-UBE2M:CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUND1,2,4,5",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1418,
      "y" : 1469
    },
    "minX" : 1352,
    "maxX" : 1550,
    "minY" : 1419,
    "maxY" : 1513,
    "prop" : {
      "x" : 1352,
      "y" : 1425,
      "width" : 133,
      "height" : 88
    },
    "textPosition" : {
      "x" : 1353,
      "y" : 1436
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1485,
          "y" : 1425
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1485,
          "y" : 1425
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 100367,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 100367,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 1488,
          "y" : 1447
        },
        "to" : {
          "x" : 1521,
          "y" : 1436
        }
      }, {
        "from" : {
          "x" : 1521,
          "y" : 1436
        },
        "to" : {
          "x" : 1543,
          "y" : 1461
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1546,
          "y" : 1464
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1546,
          "y" : 1464
        }
      }
    } ]
  }, {
    "id" : 100370,
    "reactomeId" : 10541251,
    "displayName" : "UBE2M",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1645,
      "y" : 1533
    },
    "minX" : 1586,
    "maxX" : 1701,
    "minY" : 1472,
    "maxY" : 1551,
    "prop" : {
      "x" : 1596,
      "y" : 1515,
      "width" : 99,
      "height" : 36
    },
    "textPosition" : {
      "x" : 1620,
      "y" : 1522
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1695,
          "y" : 1515
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1695,
          "y" : 1515
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 100367,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1627,
          "y" : 1512
        },
        "to" : {
          "x" : 1586,
          "y" : 1472
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1619,
          "y" : 1510
        },
        "b" : {
          "x" : 1627,
          "y" : 1512
        },
        "c" : {
          "x" : 1625,
          "y" : 1504
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1625,
          "y" : 1504
        }
      }
    } ]
  }, {
    "id" : 100373,
    "reactomeId" : 10541519,
    "displayName" : "CAND1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 525,
      "y" : 1131
    },
    "minX" : 500,
    "maxX" : 1028,
    "minY" : 1114,
    "maxY" : 1172,
    "prop" : {
      "x" : 500,
      "y" : 1120,
      "width" : 51,
      "height" : 22
    },
    "textPosition" : {
      "x" : 500,
      "y" : 1120
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 551,
          "y" : 1120
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 551,
          "y" : 1120
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 100371,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 548,
          "y" : 1145
        },
        "to" : {
          "x" : 607,
          "y" : 1170
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 100375,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 554,
          "y" : 1130
        },
        "to" : {
          "x" : 967,
          "y" : 1121
        }
      }, {
        "from" : {
          "x" : 967,
          "y" : 1121
        },
        "to" : {
          "x" : 1028,
          "y" : 1172
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 561,
          "y" : 1126
        },
        "b" : {
          "x" : 554,
          "y" : 1130
        },
        "c" : {
          "x" : 561,
          "y" : 1134
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 561,
          "y" : 1134
        }
      }
    } ]
  }, {
    "id" : 100372,
    "reactomeId" : 10541553,
    "displayName" : "CRL E3 ubiquitin ligases",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 438,
      "y" : 1206
    },
    "minX" : 383,
    "maxX" : 607,
    "minY" : 1170,
    "maxY" : 1224,
    "prop" : {
      "x" : 383,
      "y" : 1188,
      "width" : 110,
      "height" : 36
    },
    "textPosition" : {
      "x" : 382,
      "y" : 1188
    },
    "connectors" : [ {
      "edgeId" : 100371,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 499,
          "y" : 1194
        },
        "to" : {
          "x" : 607,
          "y" : 1170
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 100374,
    "reactomeId" : 10541555,
    "displayName" : "CRL E3 ubiquitin ligase:CAND1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 748,
      "y" : 1179
    },
    "minX" : 698,
    "maxX" : 889,
    "minY" : 1148,
    "maxY" : 1204,
    "prop" : {
      "x" : 698,
      "y" : 1154,
      "width" : 101,
      "height" : 50
    },
    "textPosition" : {
      "x" : 703,
      "y" : 1155
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 799,
          "y" : 1154
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 799,
          "y" : 1154
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 100371,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 100375,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 802,
          "y" : 1177
        },
        "to" : {
          "x" : 889,
          "y" : 1175
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 100377,
    "reactomeId" : 10541569,
    "displayName" : "CRL E3 ubiquitin ligase:COMMDs:CCDC22",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1144,
      "y" : 1183
    },
    "minX" : 1028,
    "maxX" : 1210,
    "minY" : 1161,
    "maxY" : 1206,
    "prop" : {
      "x" : 1078,
      "y" : 1161,
      "width" : 132,
      "height" : 45
    },
    "textPosition" : {
      "x" : 1088,
      "y" : 1159
    },
    "connectors" : [ {
      "edgeId" : 100375,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1072,
          "y" : 1176
        },
        "to" : {
          "x" : 1028,
          "y" : 1172
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1065,
          "y" : 1179
        },
        "b" : {
          "x" : 1072,
          "y" : 1176
        },
        "c" : {
          "x" : 1065,
          "y" : 1171
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1065,
          "y" : 1171
        }
      }
    } ]
  }, {
    "id" : 100376,
    "reactomeId" : 10541029,
    "displayName" : "COMMDs:CCDC22",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 703,
      "y" : 1260
    },
    "minX" : 655,
    "maxX" : 889,
    "minY" : 1175,
    "maxY" : 1278,
    "prop" : {
      "x" : 655,
      "y" : 1242,
      "width" : 96,
      "height" : 36
    },
    "textPosition" : {
      "x" : 670,
      "y" : 1243
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 751,
          "y" : 1242
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 751,
          "y" : 1242
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 100375,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 742,
          "y" : 1239
        },
        "to" : {
          "x" : 889,
          "y" : 1175
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 100379,
    "reactomeId" : 10541213,
    "displayName" : "RBX1:CUL4:DDB1:DCAFs",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 639,
      "y" : 1461
    },
    "minX" : 578,
    "maxX" : 743,
    "minY" : 1437,
    "maxY" : 1479,
    "prop" : {
      "x" : 578,
      "y" : 1443,
      "width" : 123,
      "height" : 36
    },
    "textPosition" : {
      "x" : 581,
      "y" : 1444
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 701,
          "y" : 1443
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 701,
          "y" : 1443
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 100378,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 704,
          "y" : 1466
        },
        "to" : {
          "x" : 743,
          "y" : 1470
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 100381,
    "reactomeId" : 10541561,
    "displayName" : "CRL4 E3 ubiquitin ligase:CAND1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 865,
      "y" : 1472
    },
    "minX" : 797,
    "maxX" : 963,
    "minY" : 1448,
    "maxY" : 1490,
    "prop" : {
      "x" : 797,
      "y" : 1454,
      "width" : 137,
      "height" : 36
    },
    "textPosition" : {
      "x" : 805,
      "y" : 1455
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 934,
          "y" : 1454
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 934,
          "y" : 1454
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 100378,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 100382,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 937,
          "y" : 1468
        },
        "to" : {
          "x" : 963,
          "y" : 1467
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 100380,
    "reactomeId" : 10541559,
    "displayName" : "CAND1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 689,
      "y" : 1538
    },
    "minX" : 661,
    "maxX" : 1069,
    "minY" : 1463,
    "maxY" : 1555,
    "prop" : {
      "x" : 661,
      "y" : 1527,
      "width" : 56,
      "height" : 22
    },
    "textPosition" : {
      "x" : 664,
      "y" : 1527
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 717,
          "y" : 1527
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 717,
          "y" : 1527
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 100378,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 697,
          "y" : 1524
        },
        "to" : {
          "x" : 743,
          "y" : 1470
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 100382,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 720,
          "y" : 1539
        },
        "to" : {
          "x" : 1069,
          "y" : 1555
        }
      }, {
        "from" : {
          "x" : 1069,
          "y" : 1555
        },
        "to" : {
          "x" : 1037,
          "y" : 1463
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 727,
          "y" : 1535
        },
        "b" : {
          "x" : 720,
          "y" : 1539
        },
        "c" : {
          "x" : 727,
          "y" : 1543
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 727,
          "y" : 1543
        }
      }
    } ]
  }, {
    "id" : 100383,
    "reactomeId" : 10541237,
    "displayName" : "COMMDs:CCDC22",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 939,
      "y" : 1519
    },
    "minX" : 887,
    "maxX" : 998,
    "minY" : 1467,
    "maxY" : 1537,
    "prop" : {
      "x" : 887,
      "y" : 1501,
      "width" : 105,
      "height" : 36
    },
    "textPosition" : {
      "x" : 907,
      "y" : 1502
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 992,
          "y" : 1501
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 992,
          "y" : 1501
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 100382,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 947,
          "y" : 1498
        },
        "to" : {
          "x" : 963,
          "y" : 1467
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 100384,
    "reactomeId" : 10541239,
    "displayName" : "CRL4 E3 ubiquitin ligase:COMMDs:CCDC22",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1151,
      "y" : 1459
    },
    "minX" : 1037,
    "maxX" : 1220,
    "minY" : 1428,
    "maxY" : 1485,
    "prop" : {
      "x" : 1089,
      "y" : 1434,
      "width" : 125,
      "height" : 51
    },
    "textPosition" : {
      "x" : 1091,
      "y" : 1436
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1214,
          "y" : 1434
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1214,
          "y" : 1434
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 100382,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1086,
          "y" : 1461
        },
        "to" : {
          "x" : 1037,
          "y" : 1463
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1079,
          "y" : 1465
        },
        "b" : {
          "x" : 1086,
          "y" : 1461
        },
        "c" : {
          "x" : 1079,
          "y" : 1457
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1079,
          "y" : 1457
        }
      }
    } ]
  }, {
    "id" : 100387,
    "reactomeId" : 10541653,
    "displayName" : "CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 3090,
      "y" : 669
    },
    "minX" : 2951,
    "maxX" : 3167,
    "minY" : 638,
    "maxY" : 700,
    "prop" : {
      "x" : 3013,
      "y" : 638,
      "width" : 154,
      "height" : 62
    },
    "textPosition" : {
      "x" : 3013,
      "y" : 644
    },
    "connectors" : [ {
      "edgeId" : 100385,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 3007,
          "y" : 667
        },
        "to" : {
          "x" : 2951,
          "y" : 667
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 3000,
          "y" : 671
        },
        "b" : {
          "x" : 3007,
          "y" : 667
        },
        "c" : {
          "x" : 3000,
          "y" : 663
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 3000,
          "y" : 663
        }
      }
    } ]
  }, {
    "id" : 100386,
    "reactomeId" : 10541647,
    "displayName" : "NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 2745,
      "y" : 674
    },
    "minX" : 2667,
    "maxX" : 2823,
    "minY" : 636,
    "maxY" : 712,
    "prop" : {
      "x" : 2667,
      "y" : 636,
      "width" : 156,
      "height" : 76
    },
    "textPosition" : {
      "x" : 2666,
      "y" : 649
    },
    "connectors" : [ {
      "edgeId" : 100385,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 100388,
    "reactomeId" : 10535278,
    "displayName" : "COP9",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2866,
      "y" : 612
    },
    "minX" : 2836,
    "maxX" : 2904,
    "minY" : 592,
    "maxY" : 663,
    "prop" : {
      "x" : 2836,
      "y" : 598,
      "width" : 60,
      "height" : 28
    },
    "textPosition" : {
      "x" : 2845,
      "y" : 605
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2896,
          "y" : 598
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2896,
          "y" : 598
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 100385,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 2876,
          "y" : 629
        },
        "to" : {
          "x" : 2897,
          "y" : 655
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 2900,
          "y" : 659
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2900,
          "y" : 659
        }
      }
    } ]
  }, {
    "id" : 100391,
    "reactomeId" : 10541658,
    "displayName" : "NEDD8",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 2017,
      "y" : 1565
    },
    "minX" : 1959,
    "maxX" : 2061,
    "minY" : 1476,
    "maxY" : 1580,
    "prop" : {
      "x" : 1979,
      "y" : 1551,
      "width" : 76,
      "height" : 29
    },
    "textPosition" : {
      "x" : 1991,
      "y" : 1555
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2055,
          "y" : 1551
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2055,
          "y" : 1551
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 100389,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 2007,
          "y" : 1548
        },
        "to" : {
          "x" : 1959,
          "y" : 1476
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 2000,
          "y" : 1544
        },
        "b" : {
          "x" : 2007,
          "y" : 1548
        },
        "c" : {
          "x" : 2006,
          "y" : 1540
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 2006,
          "y" : 1540
        }
      }
    } ]
  }, {
    "id" : 100390,
    "reactomeId" : 10541660,
    "displayName" : "CRL4 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2074,
      "y" : 1476
    },
    "minX" : 1959,
    "maxX" : 2147,
    "minY" : 1435,
    "maxY" : 1511,
    "prop" : {
      "x" : 2007,
      "y" : 1441,
      "width" : 134,
      "height" : 70
    },
    "textPosition" : {
      "x" : 2011,
      "y" : 1448
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2141,
          "y" : 1441
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2141,
          "y" : 1441
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 100389,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 2004,
          "y" : 1476
        },
        "to" : {
          "x" : 1959,
          "y" : 1476
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1997,
          "y" : 1480
        },
        "b" : {
          "x" : 2004,
          "y" : 1476
        },
        "c" : {
          "x" : 1997,
          "y" : 1472
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1997,
          "y" : 1472
        }
      }
    } ]
  }, {
    "id" : 100392,
    "reactomeId" : 10523933,
    "displayName" : "COP9 signalosome",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1885,
      "y" : 1536
    },
    "minX" : 1830,
    "maxX" : 1947,
    "minY" : 1481,
    "maxY" : 1554,
    "prop" : {
      "x" : 1830,
      "y" : 1518,
      "width" : 111,
      "height" : 36
    },
    "textPosition" : {
      "x" : 1842,
      "y" : 1519
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1941,
          "y" : 1518
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1941,
          "y" : 1518
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 100389,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 1883,
          "y" : 1515
        },
        "to" : {
          "x" : 1882,
          "y" : 1489
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1882,
          "y" : 1485
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1882,
          "y" : 1485
        }
      }
    } ]
  }, {
    "id" : 100395,
    "reactomeId" : 10541607,
    "displayName" : "CUL9:RBX1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1609,
      "y" : 1243
    },
    "minX" : 1562,
    "maxX" : 1706,
    "minY" : 1196,
    "maxY" : 1254,
    "prop" : {
      "x" : 1562,
      "y" : 1232,
      "width" : 95,
      "height" : 22
    },
    "textPosition" : {
      "x" : 1572,
      "y" : 1233
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1657,
          "y" : 1232
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1657,
          "y" : 1232
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 100393,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1631,
          "y" : 1229
        },
        "to" : {
          "x" : 1706,
          "y" : 1196
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 100394,
    "reactomeId" : 10509878,
    "displayName" : "NEDD8-AcM-UBE2M",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1457,
      "y" : 666
    },
    "minX" : 1415,
    "maxX" : 1706,
    "minY" : 638,
    "maxY" : 1196,
    "prop" : {
      "x" : 1415,
      "y" : 644,
      "width" : 85,
      "height" : 45
    },
    "textPosition" : {
      "x" : 1415,
      "y" : 654
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1500,
          "y" : 644
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1500,
          "y" : 644
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 100393,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1467,
          "y" : 692
        },
        "to" : {
          "x" : 1706,
          "y" : 1196
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 100396,
    "reactomeId" : 10541609,
    "displayName" : "NEDD8-AcM-UBE2M:CUL9:RBX1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1852,
      "y" : 1196
    },
    "minX" : 1785,
    "maxX" : 2023,
    "minY" : 1167,
    "maxY" : 1218,
    "prop" : {
      "x" : 1785,
      "y" : 1174,
      "width" : 135,
      "height" : 44
    },
    "textPosition" : {
      "x" : 1787,
      "y" : 1183
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1920,
          "y" : 1174
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1920,
          "y" : 1174
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 100393,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 100397,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 100397,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 1923,
          "y" : 1180
        },
        "to" : {
          "x" : 1982,
          "y" : 1167
        }
      }, {
        "from" : {
          "x" : 1982,
          "y" : 1167
        },
        "to" : {
          "x" : 2016,
          "y" : 1199
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 2019,
          "y" : 1202
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2019,
          "y" : 1202
        }
      }
    } ]
  }, {
    "id" : 100398,
    "reactomeId" : 10541614,
    "displayName" : "NEDD8-CUL9:RBX1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2192,
      "y" : 1198
    },
    "minX" : 2063,
    "maxX" : 2372,
    "minY" : 1134,
    "maxY" : 1216,
    "prop" : {
      "x" : 2122,
      "y" : 1180,
      "width" : 140,
      "height" : 36
    },
    "textPosition" : {
      "x" : 2131,
      "y" : 1195
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2262,
          "y" : 1180
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2262,
          "y" : 1180
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 100397,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 2119,
          "y" : 1201
        },
        "to" : {
          "x" : 2063,
          "y" : 1204
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 2112,
          "y" : 1205
        },
        "b" : {
          "x" : 2119,
          "y" : 1201
        },
        "c" : {
          "x" : 2112,
          "y" : 1197
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 2112,
          "y" : 1197
        }
      }
    }, {
      "edgeId" : 100399,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 2265,
          "y" : 1196
        },
        "to" : {
          "x" : 2364,
          "y" : 1195
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 2368,
          "y" : 1195
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2368,
          "y" : 1195
        }
      }
    }, {
      "edgeId" : 100404,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2228,
          "y" : 1177
        },
        "to" : {
          "x" : 2321,
          "y" : 1134
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 100401,
    "reactomeId" : 10456847,
    "displayName" : "BIRC5",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 2306,
      "y" : 1254
    },
    "minX" : 2276,
    "maxX" : 2369,
    "minY" : 1235,
    "maxY" : 1267,
    "prop" : {
      "x" : 2276,
      "y" : 1241,
      "width" : 61,
      "height" : 26
    },
    "textPosition" : {
      "x" : 2285,
      "y" : 1243
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2337,
          "y" : 1241
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2337,
          "y" : 1241
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 100399,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2340,
          "y" : 1249
        },
        "to" : {
          "x" : 2369,
          "y" : 1245
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 100400,
    "reactomeId" : 10447615,
    "displayName" : "Ub",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 2377,
      "y" : 1304
    },
    "minX" : 2365,
    "maxX" : 2390,
    "minY" : 1245,
    "maxY" : 1315,
    "prop" : {
      "x" : 2365,
      "y" : 1293,
      "width" : 25,
      "height" : 22
    },
    "textPosition" : {
      "x" : 2365,
      "y" : 1293
    },
    "connectors" : [ {
      "edgeId" : 100399,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2375,
          "y" : 1287
        },
        "to" : {
          "x" : 2369,
          "y" : 1245
        }
      } ],
      "stoichiometry" : {
        "value" : 3,
        "shape" : {
          "a" : {
            "x" : 2366,
            "y" : 1260
          },
          "b" : {
            "x" : 2378,
            "y" : 1272
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 2372,
            "y" : 1266
          }
        }
      }
    } ]
  }, {
    "id" : 100403,
    "reactomeId" : 10541633,
    "displayName" : "NEDD8-CUL9:RBX1:CUL7:CCDC8:OBSL1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2477,
      "y" : 1123
    },
    "minX" : 2385,
    "maxX" : 2547,
    "minY" : 1099,
    "maxY" : 1193,
    "prop" : {
      "x" : 2414,
      "y" : 1105,
      "width" : 127,
      "height" : 36
    },
    "textPosition" : {
      "x" : 2414,
      "y" : 1106
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2541,
          "y" : 1105
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2541,
          "y" : 1105
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 100399,
      "type" : "INHIBITOR",
      "segments" : [ {
        "from" : {
          "x" : 2452,
          "y" : 1144
        },
        "to" : {
          "x" : 2387,
          "y" : 1190
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 2385,
          "y" : 1187
        },
        "b" : {
          "x" : 2389,
          "y" : 1193
        },
        "c" : {
          "x" : 2387,
          "y" : 1190
        },
        "type" : "STOP",
        "centre" : {
          "x" : 2387,
          "y" : 1190
        }
      }
    }, {
      "edgeId" : 100404,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 100402,
    "reactomeId" : 10541620,
    "displayName" : "ub-BIRC5",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 2465,
      "y" : 1182
    },
    "minX" : 2433,
    "maxX" : 2504,
    "minY" : 1165,
    "maxY" : 1193,
    "prop" : {
      "x" : 2433,
      "y" : 1171,
      "width" : 65,
      "height" : 22
    },
    "textPosition" : {
      "x" : 2434,
      "y" : 1171
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2498,
          "y" : 1171
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2498,
          "y" : 1171
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 100399,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 100405,
    "reactomeId" : 10541631,
    "displayName" : "CUL7:CCDC8:OBSL1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2210,
      "y" : 1133
    },
    "minX" : 2162,
    "maxX" : 2321,
    "minY" : 1109,
    "maxY" : 1152,
    "prop" : {
      "x" : 2162,
      "y" : 1115,
      "width" : 97,
      "height" : 37
    },
    "textPosition" : {
      "x" : 2166,
      "y" : 1117
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2259,
          "y" : 1115
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2259,
          "y" : 1115
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 100404,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2262,
          "y" : 1133
        },
        "to" : {
          "x" : 2321,
          "y" : 1134
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 100407,
    "reactomeId" : 10541667,
    "displayName" : "RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2677,
      "y" : 896
    },
    "minX" : 2593,
    "maxX" : 3663,
    "minY" : 755,
    "maxY" : 959,
    "prop" : {
      "x" : 2593,
      "y" : 865,
      "width" : 168,
      "height" : 62
    },
    "textPosition" : {
      "x" : 2593,
      "y" : 878
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2761,
          "y" : 865
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2761,
          "y" : 865
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 100432,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 2694,
          "y" : 862
        },
        "to" : {
          "x" : 2752,
          "y" : 766
        }
      }, {
        "from" : {
          "x" : 2752,
          "y" : 766
        },
        "to" : {
          "x" : 3663,
          "y" : 755
        }
      }, {
        "from" : {
          "x" : 3663,
          "y" : 755
        },
        "to" : {
          "x" : 3627,
          "y" : 873
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 2694,
          "y" : 854
        },
        "b" : {
          "x" : 2694,
          "y" : 862
        },
        "c" : {
          "x" : 2701,
          "y" : 858
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 2701,
          "y" : 858
        }
      }
    }, {
      "edgeId" : 100445,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2746,
          "y" : 930
        },
        "to" : {
          "x" : 2818,
          "y" : 959
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 100406,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2764,
          "y" : 886
        },
        "to" : {
          "x" : 2841,
          "y" : 877
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 100409,
    "reactomeId" : 10541680,
    "displayName" : "RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:hydroxyPro-HIF-alpha",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 3025,
      "y" : 862
    },
    "minX" : 2918,
    "maxX" : 3259,
    "minY" : 776,
    "maxY" : 891,
    "prop" : {
      "x" : 2918,
      "y" : 834,
      "width" : 215,
      "height" : 57
    },
    "textPosition" : {
      "x" : 2928,
      "y" : 842
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 3133,
          "y" : 834
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3133,
          "y" : 834
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 100406,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 100410,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 3136,
          "y" : 858
        },
        "to" : {
          "x" : 3216,
          "y" : 855
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 100410,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 3093,
          "y" : 831
        },
        "to" : {
          "x" : 3233,
          "y" : 776
        }
      }, {
        "from" : {
          "x" : 3233,
          "y" : 776
        },
        "to" : {
          "x" : 3254,
          "y" : 842
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 3255,
          "y" : 846
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3255,
          "y" : 846
        }
      }
    } ]
  }, {
    "id" : 100408,
    "reactomeId" : 10489469,
    "displayName" : "hydroxyPro-HIF-alpha",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 2800,
      "y" : 824
    },
    "minX" : 2747,
    "maxX" : 2853,
    "minY" : 806,
    "maxY" : 877,
    "prop" : {
      "x" : 2747,
      "y" : 806,
      "width" : 106,
      "height" : 36
    },
    "textPosition" : {
      "x" : 2748,
      "y" : 806
    },
    "connectors" : [ {
      "edgeId" : 100406,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2813,
          "y" : 848
        },
        "to" : {
          "x" : 2841,
          "y" : 877
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 100411,
    "reactomeId" : 10459556,
    "displayName" : "UBE2D1,2,3:Ubiquitin",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 3130,
      "y" : 923
    },
    "minX" : 3088,
    "maxX" : 3216,
    "minY" : 855,
    "maxY" : 941,
    "prop" : {
      "x" : 3088,
      "y" : 905,
      "width" : 84,
      "height" : 36
    },
    "textPosition" : {
      "x" : 3098,
      "y" : 892
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 3172,
          "y" : 905
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3172,
          "y" : 905
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 100410,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 3152,
          "y" : 902
        },
        "to" : {
          "x" : 3216,
          "y" : 855
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 100413,
    "reactomeId" : 10541684,
    "displayName" : "ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:NEDD8-CUL2:RBX1:COMMDs:CCDC22:DCUN1D1,2,4,5",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 3441,
      "y" : 863
    },
    "minX" : 3294,
    "maxX" : 3545,
    "minY" : 822,
    "maxY" : 899,
    "prop" : {
      "x" : 3343,
      "y" : 828,
      "width" : 196,
      "height" : 71
    },
    "textPosition" : {
      "x" : 3346,
      "y" : 836
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 3539,
          "y" : 828
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3539,
          "y" : 828
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 100432,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 100410,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 3340,
          "y" : 857
        },
        "to" : {
          "x" : 3294,
          "y" : 855
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 3333,
          "y" : 861
        },
        "b" : {
          "x" : 3340,
          "y" : 857
        },
        "c" : {
          "x" : 3333,
          "y" : 853
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 3333,
          "y" : 853
        }
      }
    } ]
  }, {
    "id" : 100412,
    "reactomeId" : 10459554,
    "displayName" : "UBE2D1,2,3",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 3329,
      "y" : 780
    },
    "minX" : 3278,
    "maxX" : 3381,
    "minY" : 768,
    "maxY" : 855,
    "prop" : {
      "x" : 3278,
      "y" : 768,
      "width" : 103,
      "height" : 24
    },
    "textPosition" : {
      "x" : 3288,
      "y" : 769
    },
    "connectors" : [ {
      "edgeId" : 100410,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 3323,
          "y" : 798
        },
        "to" : {
          "x" : 3294,
          "y" : 855
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 3323,
          "y" : 806
        },
        "b" : {
          "x" : 3323,
          "y" : 798
        },
        "c" : {
          "x" : 3316,
          "y" : 802
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 3316,
          "y" : 802
        }
      }
    } ]
  }, {
    "id" : 100414,
    "reactomeId" : 10541673,
    "displayName" : "RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:UBXN7",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 3249,
      "y" : 979
    },
    "minX" : 3166,
    "maxX" : 3339,
    "minY" : 866,
    "maxY" : 1008,
    "prop" : {
      "x" : 3166,
      "y" : 951,
      "width" : 167,
      "height" : 57
    },
    "textPosition" : {
      "x" : 3171,
      "y" : 959
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 3333,
          "y" : 951
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3333,
          "y" : 951
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 100445,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 100410,
      "type" : "INHIBITOR",
      "segments" : [ {
        "from" : {
          "x" : 3251,
          "y" : 948
        },
        "to" : {
          "x" : 3258,
          "y" : 866
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 3254,
          "y" : 866
        },
        "b" : {
          "x" : 3262,
          "y" : 866
        },
        "c" : {
          "x" : 3258,
          "y" : 866
        },
        "type" : "STOP",
        "centre" : {
          "x" : 3258,
          "y" : 866
        }
      }
    } ]
  }, {
    "id" : 100417,
    "reactomeId" : 10541692,
    "displayName" : "NUB1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 366,
      "y" : 171
    },
    "minX" : 334,
    "maxX" : 761,
    "minY" : 126,
    "maxY" : 203,
    "prop" : {
      "x" : 334,
      "y" : 157,
      "width" : 64,
      "height" : 29
    },
    "textPosition" : {
      "x" : 345,
      "y" : 161
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 398,
          "y" : 157
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 398,
          "y" : 157
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 100420,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 404,
          "y" : 165
        },
        "to" : {
          "x" : 644,
          "y" : 126
        }
      }, {
        "from" : {
          "x" : 644,
          "y" : 126
        },
        "to" : {
          "x" : 761,
          "y" : 195
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 410,
          "y" : 160
        },
        "b" : {
          "x" : 404,
          "y" : 165
        },
        "c" : {
          "x" : 411,
          "y" : 168
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 411,
          "y" : 168
        }
      }
    }, {
      "edgeId" : 100415,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 404,
          "y" : 180
        },
        "to" : {
          "x" : 475,
          "y" : 203
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 100416,
    "reactomeId" : 10541698,
    "displayName" : "NEDD8,UBD",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 361,
      "y" : 242
    },
    "minX" : 322,
    "maxX" : 475,
    "minY" : 203,
    "maxY" : 253,
    "prop" : {
      "x" : 322,
      "y" : 231,
      "width" : 79,
      "height" : 22
    },
    "textPosition" : {
      "x" : 334,
      "y" : 225
    },
    "connectors" : [ {
      "edgeId" : 100415,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 393,
          "y" : 225
        },
        "to" : {
          "x" : 475,
          "y" : 203
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 100419,
    "reactomeId" : 10541700,
    "displayName" : "NEDD8,UBD:NUB1:26S proteasome",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 613,
      "y" : 200
    },
    "minX" : 547,
    "maxX" : 686,
    "minY" : 173,
    "maxY" : 221,
    "prop" : {
      "x" : 547,
      "y" : 179,
      "width" : 133,
      "height" : 42
    },
    "textPosition" : {
      "x" : 552,
      "y" : 186
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 680,
          "y" : 179
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 680,
          "y" : 179
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 100420,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 100415,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 100418,
    "reactomeId" : 10447709,
    "displayName" : "26S proteasome",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 393,
      "y" : 120
    },
    "minX" : 342,
    "maxX" : 761,
    "minY" : 76,
    "maxY" : 203,
    "prop" : {
      "x" : 342,
      "y" : 109,
      "width" : 103,
      "height" : 22
    },
    "textPosition" : {
      "x" : 351,
      "y" : 96
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 445,
          "y" : 109
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 445,
          "y" : 109
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 100420,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 448,
          "y" : 111
        },
        "to" : {
          "x" : 667,
          "y" : 76
        }
      }, {
        "from" : {
          "x" : 667,
          "y" : 76
        },
        "to" : {
          "x" : 761,
          "y" : 195
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 454,
          "y" : 106
        },
        "b" : {
          "x" : 448,
          "y" : 111
        },
        "c" : {
          "x" : 455,
          "y" : 114
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 455,
          "y" : 114
        }
      }
    }, {
      "edgeId" : 100415,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 403,
          "y" : 134
        },
        "to" : {
          "x" : 475,
          "y" : 203
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 100423,
    "reactomeId" : 10541707,
    "displayName" : "DCUN1D3",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 2040,
      "y" : 32
    },
    "minX" : 1972,
    "maxX" : 2177,
    "minY" : 7,
    "maxY" : 52,
    "prop" : {
      "x" : 1972,
      "y" : 13,
      "width" : 136,
      "height" : 39
    },
    "textPosition" : {
      "x" : 2006,
      "y" : 22
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2108,
          "y" : 13
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2108,
          "y" : 13
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 100421,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2111,
          "y" : 34
        },
        "to" : {
          "x" : 2177,
          "y" : 37
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 100422,
    "reactomeId" : 10541031,
    "displayName" : "CRL1 E3 ubiquitin ligase:COMMDs:CCDC22",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1599,
      "y" : 558
    },
    "minX" : 1522,
    "maxX" : 2177,
    "minY" : 37,
    "maxY" : 586,
    "prop" : {
      "x" : 1522,
      "y" : 531,
      "width" : 154,
      "height" : 55
    },
    "textPosition" : {
      "x" : 1539,
      "y" : 537
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1676,
          "y" : 531
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1676,
          "y" : 531
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 100421,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1679,
          "y" : 545
        },
        "to" : {
          "x" : 2074,
          "y" : 479
        }
      }, {
        "from" : {
          "x" : 2074,
          "y" : 479
        },
        "to" : {
          "x" : 2177,
          "y" : 37
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 100424,
    "reactomeId" : 10541709,
    "displayName" : "CRL1 E3 ubiquitin ligase complex:MyrG-DCUN1D3",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2392,
      "y" : 36
    },
    "minX" : 2307,
    "maxX" : 2483,
    "minY" : 0,
    "maxY" : 67,
    "prop" : {
      "x" : 2307,
      "y" : 6,
      "width" : 170,
      "height" : 61
    },
    "textPosition" : {
      "x" : 2311,
      "y" : 32
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2477,
          "y" : 6
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2477,
          "y" : 6
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 100421,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 100427,
    "reactomeId" : 10447615,
    "displayName" : "Ub",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 2828,
      "y" : 1015
    },
    "minX" : 2816,
    "maxX" : 2841,
    "minY" : 1004,
    "maxY" : 1079,
    "prop" : {
      "x" : 2816,
      "y" : 1004,
      "width" : 25,
      "height" : 22
    },
    "textPosition" : {
      "x" : 2816,
      "y" : 1004
    },
    "connectors" : [ {
      "edgeId" : 100425,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2829,
          "y" : 1032
        },
        "to" : {
          "x" : 2836,
          "y" : 1079
        }
      } ],
      "stoichiometry" : {
        "value" : 3,
        "shape" : {
          "a" : {
            "x" : 2826,
            "y" : 1049
          },
          "b" : {
            "x" : 2838,
            "y" : 1061
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 2832,
            "y" : 1055
          }
        }
      }
    }, {
      "edgeId" : 100430,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 100426,
    "reactomeId" : 10541671,
    "displayName" : "UBXN7",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 2732,
      "y" : 983
    },
    "minX" : 2701,
    "maxX" : 2836,
    "minY" : 959,
    "maxY" : 1332,
    "prop" : {
      "x" : 2701,
      "y" : 971,
      "width" : 63,
      "height" : 24
    },
    "textPosition" : {
      "x" : 2708,
      "y" : 972
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2764,
          "y" : 971
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2764,
          "y" : 971
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 100425,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2745,
          "y" : 998
        },
        "to" : {
          "x" : 2836,
          "y" : 1079
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 100440,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2733,
          "y" : 998
        },
        "to" : {
          "x" : 2763,
          "y" : 1332
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 100445,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2767,
          "y" : 974
        },
        "to" : {
          "x" : 2818,
          "y" : 959
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 100429,
    "reactomeId" : 10541675,
    "displayName" : "MUL1 dimer",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2867,
      "y" : 1134
    },
    "minX" : 2825,
    "maxX" : 2988,
    "minY" : 964,
    "maxY" : 1150,
    "prop" : {
      "x" : 2825,
      "y" : 1119,
      "width" : 84,
      "height" : 31
    },
    "textPosition" : {
      "x" : 2827,
      "y" : 1129
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2909,
          "y" : 1119
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2909,
          "y" : 1119
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 100425,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 2867,
          "y" : 1116
        },
        "to" : {
          "x" : 2869,
          "y" : 1096
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 2869,
          "y" : 1092
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2869,
          "y" : 1092
        }
      }
    }, {
      "edgeId" : 100445,
      "type" : "INHIBITOR",
      "segments" : [ {
        "from" : {
          "x" : 2877,
          "y" : 1116
        },
        "to" : {
          "x" : 2985,
          "y" : 966
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 2982,
          "y" : 964
        },
        "b" : {
          "x" : 2988,
          "y" : 968
        },
        "c" : {
          "x" : 2985,
          "y" : 966
        },
        "type" : "STOP",
        "centre" : {
          "x" : 2985,
          "y" : 966
        }
      }
    } ]
  }, {
    "id" : 100428,
    "reactomeId" : 10549206,
    "displayName" : "UBXN7",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 3022,
      "y" : 1075
    },
    "minX" : 2977,
    "maxX" : 3074,
    "minY" : 1050,
    "maxY" : 1095,
    "prop" : {
      "x" : 2977,
      "y" : 1056,
      "width" : 91,
      "height" : 39
    },
    "textPosition" : {
      "x" : 2998,
      "y" : 1065
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 3068,
          "y" : 1056
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3068,
          "y" : 1056
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 100425,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 100430,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 100431,
    "reactomeId" : 10447709,
    "displayName" : "26S proteasome",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 3254,
      "y" : 1106
    },
    "minX" : 3111,
    "maxX" : 3584,
    "minY" : 879,
    "maxY" : 1224,
    "prop" : {
      "x" : 3203,
      "y" : 1095,
      "width" : 103,
      "height" : 22
    },
    "textPosition" : {
      "x" : 3212,
      "y" : 1082
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 3306,
          "y" : 1095
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3306,
          "y" : 1095
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 100430,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 3233,
          "y" : 1092
        },
        "to" : {
          "x" : 3118,
          "y" : 1032
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 3115,
          "y" : 1031
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3115,
          "y" : 1031
        }
      }
    }, {
      "edgeId" : 100432,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 3270,
          "y" : 1092
        },
        "to" : {
          "x" : 3577,
          "y" : 885
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 3580,
          "y" : 883
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3580,
          "y" : 883
        }
      }
    }, {
      "edgeId" : 100446,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 3255,
          "y" : 1120
        },
        "to" : {
          "x" : 3265,
          "y" : 1216
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 3266,
          "y" : 1220
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3266,
          "y" : 1220
        }
      }
    } ]
  }, {
    "id" : 100433,
    "reactomeId" : 10447615,
    "displayName" : "Ub",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 3681,
      "y" : 917
    },
    "minX" : 3627,
    "maxX" : 3694,
    "minY" : 873,
    "maxY" : 928,
    "prop" : {
      "x" : 3669,
      "y" : 906,
      "width" : 25,
      "height" : 22
    },
    "textPosition" : {
      "x" : 3669,
      "y" : 906
    },
    "connectors" : [ {
      "edgeId" : 100432,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 3663,
          "y" : 906
        },
        "to" : {
          "x" : 3627,
          "y" : 873
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 3655,
          "y" : 904
        },
        "b" : {
          "x" : 3663,
          "y" : 906
        },
        "c" : {
          "x" : 3661,
          "y" : 898
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 3661,
          "y" : 898
        }
      }
    } ]
  }, {
    "id" : 100435,
    "reactomeId" : 10548561,
    "displayName" : "KEAP1:NEDD8-CUL3:RBX1:NFE2L2",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2909,
      "y" : 1408
    },
    "minX" : 2848,
    "maxX" : 3058,
    "minY" : 1380,
    "maxY" : 1459,
    "prop" : {
      "x" : 2848,
      "y" : 1386,
      "width" : 123,
      "height" : 44
    },
    "textPosition" : {
      "x" : 2860,
      "y" : 1381
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2971,
          "y" : 1386
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2971,
          "y" : 1386
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 100434,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2974,
          "y" : 1411
        },
        "to" : {
          "x" : 3019,
          "y" : 1415
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 100434,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 2954,
          "y" : 1433
        },
        "to" : {
          "x" : 3015,
          "y" : 1459
        }
      }, {
        "from" : {
          "x" : 3015,
          "y" : 1459
        },
        "to" : {
          "x" : 3051,
          "y" : 1428
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 3054,
          "y" : 1425
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3054,
          "y" : 1425
        }
      }
    } ]
  }, {
    "id" : 100437,
    "reactomeId" : 10549213,
    "displayName" : "ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 3284,
      "y" : 1415
    },
    "minX" : 3223,
    "maxX" : 3352,
    "minY" : 1329,
    "maxY" : 1434,
    "prop" : {
      "x" : 3223,
      "y" : 1397,
      "width" : 123,
      "height" : 37
    },
    "textPosition" : {
      "x" : 3224,
      "y" : 1399
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 3346,
          "y" : 1397
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3346,
          "y" : 1397
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 100434,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 100443,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 3277,
          "y" : 1394
        },
        "to" : {
          "x" : 3252,
          "y" : 1329
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 100436,
    "reactomeId" : 10447615,
    "displayName" : "Ub",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 2993,
      "y" : 1295
    },
    "minX" : 2981,
    "maxX" : 3019,
    "minY" : 1284,
    "maxY" : 1415,
    "prop" : {
      "x" : 2981,
      "y" : 1284,
      "width" : 25,
      "height" : 22
    },
    "textPosition" : {
      "x" : 2981,
      "y" : 1284
    },
    "connectors" : [ {
      "edgeId" : 100434,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2995,
          "y" : 1312
        },
        "to" : {
          "x" : 3019,
          "y" : 1415
        }
      } ],
      "stoichiometry" : {
        "value" : 3,
        "shape" : {
          "a" : {
            "x" : 3001,
            "y" : 1357
          },
          "b" : {
            "x" : 3013,
            "y" : 1369
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 3007,
            "y" : 1363
          }
        }
      }
    }, {
      "edgeId" : 100446,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 100439,
    "reactomeId" : 10548563,
    "displayName" : "NFE2L2 inducers:KEAP1:CUL3:RBX1:NFE2L2",
    "schemaClass" : "Complex",
    "renderableClass" : "ComplexDrug",
    "position" : {
      "x" : 3160,
      "y" : 1483
    },
    "minX" : 3069,
    "maxX" : 3226,
    "minY" : 1419,
    "maxY" : 1509,
    "prop" : {
      "x" : 3100,
      "y" : 1458,
      "width" : 120,
      "height" : 51
    },
    "textPosition" : {
      "x" : 3102,
      "y" : 1460
    },
    "bgColor" : {
      "r" : 184,
      "g" : 154,
      "b" : 230
    },
    "fgColor" : {
      "r" : 161,
      "g" : 1,
      "b" : 2
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 3220,
          "y" : 1458
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3220,
          "y" : 1458
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 100434,
      "type" : "INHIBITOR",
      "segments" : [ {
        "from" : {
          "x" : 3122,
          "y" : 1455
        },
        "to" : {
          "x" : 3071,
          "y" : 1422
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 3069,
          "y" : 1425
        },
        "b" : {
          "x" : 3073,
          "y" : 1419
        },
        "c" : {
          "x" : 3071,
          "y" : 1422
        },
        "type" : "STOP",
        "centre" : {
          "x" : 3071,
          "y" : 1422
        }
      }
    } ]
  }, {
    "id" : 100438,
    "reactomeId" : 1250243,
    "displayName" : "ROS",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 3056,
      "y" : 1361
    },
    "minX" : 3036,
    "maxX" : 3077,
    "minY" : 1345,
    "maxY" : 1409,
    "prop" : {
      "x" : 3036,
      "y" : 1346,
      "width" : 40,
      "height" : 31
    },
    "textPosition" : {
      "x" : 3039,
      "y" : 1351
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 3071,
          "y" : 1351
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3071,
          "y" : 1351
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 100434,
      "type" : "INHIBITOR",
      "segments" : [ {
        "from" : {
          "x" : 3057,
          "y" : 1380
        },
        "to" : {
          "x" : 3062,
          "y" : 1408
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 3058,
          "y" : 1409
        },
        "b" : {
          "x" : 3066,
          "y" : 1407
        },
        "c" : {
          "x" : 3062,
          "y" : 1408
        },
        "type" : "STOP",
        "centre" : {
          "x" : 3062,
          "y" : 1408
        }
      }
    } ]
  }, {
    "id" : 100441,
    "reactomeId" : 10549313,
    "displayName" : "NPLOC4:UFD1:VCP hexamer",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2619,
      "y" : 1334
    },
    "minX" : 2559,
    "maxX" : 2763,
    "minY" : 1310,
    "maxY" : 1353,
    "prop" : {
      "x" : 2559,
      "y" : 1316,
      "width" : 120,
      "height" : 37
    },
    "textPosition" : {
      "x" : 2570,
      "y" : 1318
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2679,
          "y" : 1316
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2679,
          "y" : 1316
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 100440,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2682,
          "y" : 1333
        },
        "to" : {
          "x" : 2763,
          "y" : 1332
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 100442,
    "reactomeId" : 10549225,
    "displayName" : "UBXN7:NPLOC4:UBF1:VCP hexamer",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 3140,
      "y" : 1328
    },
    "minX" : 3080,
    "maxX" : 3252,
    "minY" : 1304,
    "maxY" : 1347,
    "prop" : {
      "x" : 3080,
      "y" : 1310,
      "width" : 120,
      "height" : 37
    },
    "textPosition" : {
      "x" : 3087,
      "y" : 1298
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 3200,
          "y" : 1310
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3200,
          "y" : 1310
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 100440,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 100443,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 3203,
          "y" : 1328
        },
        "to" : {
          "x" : 3252,
          "y" : 1329
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 100444,
    "reactomeId" : 10549227,
    "displayName" : "ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1:UBXN7:UBF1:NPLOC4:VCP hexamer",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 3427,
      "y" : 1332
    },
    "minX" : 3364,
    "maxX" : 3497,
    "minY" : 1287,
    "maxY" : 1372,
    "prop" : {
      "x" : 3364,
      "y" : 1293,
      "width" : 127,
      "height" : 79
    },
    "textPosition" : {
      "x" : 3365,
      "y" : 1295
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 3491,
          "y" : 1293
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3491,
          "y" : 1293
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 100443,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 100447,
    "reactomeId" : 10538105,
    "displayName" : "NFE2L2",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 3679,
      "y" : 1339
    },
    "minX" : 3642,
    "maxX" : 3723,
    "minY" : 1322,
    "maxY" : 1351,
    "prop" : {
      "x" : 3642,
      "y" : 1328,
      "width" : 75,
      "height" : 23
    },
    "textPosition" : {
      "x" : 3652,
      "y" : 1329
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 3717,
          "y" : 1328
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 3717,
          "y" : 1328
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 100446,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 100456,
    "reactomeId" : 10541645,
    "displayName" : "NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1946,
      "y" : 400
    },
    "minX" : 1868,
    "maxX" : 2031,
    "minY" : 370,
    "maxY" : 425,
    "prop" : {
      "x" : 1868,
      "y" : 376,
      "width" : 157,
      "height" : 49
    },
    "textPosition" : {
      "x" : 1887,
      "y" : 362
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2025,
          "y" : 376
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2025,
          "y" : 376
        }
      }
    },
    "connectors" : [ ]
  }, {
    "id" : 100465,
    "reactomeId" : 10541157,
    "displayName" : "CRL3 E3 ubiquitin ligase:COMMDs:CCDC22",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1386,
      "y" : 1052
    },
    "minX" : 1319,
    "maxX" : 1459,
    "minY" : 1020,
    "maxY" : 1078,
    "prop" : {
      "x" : 1319,
      "y" : 1026,
      "width" : 134,
      "height" : 52
    },
    "textPosition" : {
      "x" : 1326,
      "y" : 1029
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1453,
          "y" : 1026
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1453,
          "y" : 1026
        }
      }
    },
    "connectors" : [ ]
  }, {
    "id" : 100464,
    "reactomeId" : 10541567,
    "displayName" : "CRL5 E3 ubiquitin ligase:COMMDs:CCDC22",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1342,
      "y" : 259
    },
    "minX" : 1270,
    "maxX" : 1421,
    "minY" : 228,
    "maxY" : 284,
    "prop" : {
      "x" : 1270,
      "y" : 234,
      "width" : 145,
      "height" : 50
    },
    "textPosition" : {
      "x" : 1282,
      "y" : 235
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1415,
          "y" : 234
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1415,
          "y" : 234
        }
      }
    },
    "connectors" : [ ]
  }, {
    "id" : 100466,
    "reactomeId" : 10541069,
    "displayName" : "CRL2 E3 ubiquitin ligase:COMMDs:CCDC22",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1469,
      "y" : 845
    },
    "minX" : 1411,
    "maxX" : 1534,
    "minY" : 815,
    "maxY" : 870,
    "prop" : {
      "x" : 1411,
      "y" : 821,
      "width" : 117,
      "height" : 49
    },
    "textPosition" : {
      "x" : 1410,
      "y" : 821
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1528,
          "y" : 821
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1528,
          "y" : 821
        }
      }
    },
    "connectors" : [ ]
  }, {
    "id" : 100469,
    "reactomeId" : 10548559,
    "displayName" : "KEAP1:NEDD8-CUL3:RBX1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 2697,
      "y" : 1562
    },
    "minX" : 2630,
    "maxX" : 2771,
    "minY" : 1538,
    "maxY" : 1580,
    "prop" : {
      "x" : 2630,
      "y" : 1544,
      "width" : 135,
      "height" : 36
    },
    "textPosition" : {
      "x" : 2631,
      "y" : 1545
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2765,
          "y" : 1544
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2765,
          "y" : 1544
        }
      }
    },
    "connectors" : [ ]
  }, {
    "id" : 100468,
    "reactomeId" : 10548555,
    "displayName" : "NFE2L2",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 2684,
      "y" : 1429
    },
    "minX" : 2646,
    "maxX" : 2729,
    "minY" : 1410,
    "maxY" : 1442,
    "prop" : {
      "x" : 2646,
      "y" : 1416,
      "width" : 77,
      "height" : 26
    },
    "textPosition" : {
      "x" : 2657,
      "y" : 1418
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2723,
          "y" : 1416
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2723,
          "y" : 1416
        }
      }
    },
    "connectors" : [ ]
  }, {
    "id" : 100471,
    "reactomeId" : 10558287,
    "displayName" : "KEAP1-NFE2L2 pathway",
    "schemaClass" : "Pathway",
    "renderableClass" : "EncapsulatedNode",
    "position" : {
      "x" : 2600,
      "y" : 1489
    },
    "minX" : 2533,
    "maxX" : 2667,
    "minY" : 1460,
    "maxY" : 1518,
    "prop" : {
      "x" : 2533,
      "y" : 1460,
      "width" : 134,
      "height" : 58
    },
    "textPosition" : {
      "x" : 2545,
      "y" : 1467
    },
    "connectors" : [ ]
  } ],
  "edges" : [ {
    "id" : 100355,
    "reactomeId" : 10521727,
    "displayName" : "UCHL3, SENP8 cleave NEDD8",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 223,
      "y" : 478
    },
    "minX" : 196,
    "maxX" : 247,
    "minY" : 472,
    "maxY" : 484,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 196,
        "y" : 480
      },
      "to" : {
        "x" : 223,
        "y" : 478
      }
    }, {
      "from" : {
        "x" : 223,
        "y" : 478
      },
      "to" : {
        "x" : 247,
        "y" : 478
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 217,
        "y" : 472
      },
      "b" : {
        "x" : 229,
        "y" : 484
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 223,
        "y" : 478
      }
    },
    "inputs" : [ {
      "id" : 100356,
      "points" : [ {
        "x" : 153,
        "y" : 511
      } ]
    }, {
      "id" : 100357,
      "points" : [ {
        "x" : 171,
        "y" : 477
      } ]
    } ],
    "outputs" : [ {
      "id" : 100358,
      "points" : [ {
        "x" : 297,
        "y" : 478
      } ]
    }, {
      "id" : 100359,
      "points" : [ {
        "x" : 273,
        "y" : 506
      } ]
    } ],
    "catalysts" : [ {
      "id" : 100357,
      "points" : [ {
        "x" : 156,
        "y" : 444
      }, {
        "x" : 177,
        "y" : 434
      } ]
    } ]
  }, {
    "id" : 100421,
    "reactomeId" : 10541711,
    "displayName" : "MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2244,
      "y" : 40
    },
    "minX" : 2177,
    "maxX" : 2304,
    "minY" : 34,
    "maxY" : 46,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 2177,
        "y" : 37
      },
      "to" : {
        "x" : 2244,
        "y" : 40
      }
    }, {
      "from" : {
        "x" : 2244,
        "y" : 40
      },
      "to" : {
        "x" : 2304,
        "y" : 38
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 2297,
        "y" : 42
      },
      "b" : {
        "x" : 2304,
        "y" : 38
      },
      "c" : {
        "x" : 2297,
        "y" : 34
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 2297,
        "y" : 34
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 2244,
        "y" : 40
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 2244,
        "y" : 40
      }
    },
    "inputs" : [ {
      "id" : 100422,
      "points" : [ {
        "x" : 1679,
        "y" : 545
      }, {
        "x" : 2074,
        "y" : 479
      } ]
    }, {
      "id" : 100423,
      "points" : [ {
        "x" : 2111,
        "y" : 34
      } ]
    } ],
    "outputs" : [ {
      "id" : 100424
    } ]
  }, {
    "id" : 100420,
    "reactomeId" : 10541704,
    "displayName" : "26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 706,
      "y" : 195
    },
    "minX" : 683,
    "maxX" : 761,
    "minY" : 189,
    "maxY" : 201,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 683,
        "y" : 196
      },
      "to" : {
        "x" : 706,
        "y" : 195
      }
    }, {
      "from" : {
        "x" : 706,
        "y" : 195
      },
      "to" : {
        "x" : 761,
        "y" : 195
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 700,
        "y" : 189
      },
      "b" : {
        "x" : 712,
        "y" : 201
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 706,
        "y" : 195
      }
    },
    "inputs" : [ {
      "id" : 100419
    } ],
    "outputs" : [ {
      "id" : 100417,
      "points" : [ {
        "x" : 404,
        "y" : 165
      }, {
        "x" : 644,
        "y" : 126
      } ]
    }, {
      "id" : 100418,
      "points" : [ {
        "x" : 448,
        "y" : 111
      }, {
        "x" : 667,
        "y" : 76
      } ]
    } ]
  }, {
    "id" : 100425,
    "reactomeId" : 10549209,
    "displayName" : "MUL1 ubiquitinates UBXN7",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2870,
      "y" : 1080
    },
    "minX" : 2836,
    "maxX" : 2974,
    "minY" : 1074,
    "maxY" : 1086,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 2836,
        "y" : 1079
      },
      "to" : {
        "x" : 2870,
        "y" : 1080
      }
    }, {
      "from" : {
        "x" : 2870,
        "y" : 1080
      },
      "to" : {
        "x" : 2974,
        "y" : 1076
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 2967,
        "y" : 1080
      },
      "b" : {
        "x" : 2974,
        "y" : 1076
      },
      "c" : {
        "x" : 2967,
        "y" : 1072
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 2967,
        "y" : 1072
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 2864,
        "y" : 1074
      },
      "b" : {
        "x" : 2876,
        "y" : 1086
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 2870,
        "y" : 1080
      }
    },
    "inputs" : [ {
      "id" : 100426,
      "points" : [ {
        "x" : 2745,
        "y" : 998
      } ]
    }, {
      "id" : 100427,
      "points" : [ {
        "x" : 2829,
        "y" : 1032
      } ],
      "stoichiometry" : 3
    } ],
    "outputs" : [ {
      "id" : 100428
    } ],
    "catalysts" : [ {
      "id" : 100429,
      "points" : [ {
        "x" : 2867,
        "y" : 1116
      } ]
    } ]
  }, {
    "id" : 100360,
    "reactomeId" : 10540254,
    "displayName" : "Release of mature NEDD8",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 437,
      "y" : 472
    },
    "minX" : 416,
    "maxX" : 461,
    "minY" : 466,
    "maxY" : 485,
    "reactionType" : "dissociation",
    "segments" : [ {
      "from" : {
        "x" : 416,
        "y" : 473
      },
      "to" : {
        "x" : 437,
        "y" : 472
      }
    }, {
      "from" : {
        "x" : 437,
        "y" : 472
      },
      "to" : {
        "x" : 461,
        "y" : 485
      }
    } ],
    "reactionShape" : {
      "c" : {
        "x" : 437,
        "y" : 472
      },
      "r" : 5,
      "r1" : 3,
      "type" : "DOUBLE_CIRCLE",
      "empty" : true,
      "centre" : {
        "x" : 437,
        "y" : 472
      }
    },
    "inputs" : [ {
      "id" : 100358
    } ],
    "outputs" : [ {
      "id" : 100361,
      "points" : [ {
        "x" : 478,
        "y" : 498
      } ]
    }, {
      "id" : 100362,
      "points" : [ {
        "x" : 505,
        "y" : 424
      } ]
    } ]
  }, {
    "id" : 100363,
    "reactomeId" : 10541083,
    "displayName" : "AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2049,
      "y" : 825
    },
    "minX" : 1966,
    "maxX" : 2084,
    "minY" : 819,
    "maxY" : 831,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1966,
        "y" : 827
      },
      "to" : {
        "x" : 2049,
        "y" : 825
      }
    }, {
      "from" : {
        "x" : 2049,
        "y" : 825
      },
      "to" : {
        "x" : 2084,
        "y" : 825
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 2043,
        "y" : 819
      },
      "b" : {
        "x" : 2055,
        "y" : 831
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 2049,
        "y" : 825
      }
    },
    "inputs" : [ {
      "id" : 100364
    } ],
    "outputs" : [ {
      "id" : 100365,
      "points" : [ {
        "x" : 929,
        "y" : 722
      }, {
        "x" : 1453,
        "y" : 886
      }, {
        "x" : 2084,
        "y" : 878
      } ]
    }, {
      "id" : 100366,
      "points" : [ {
        "x" : 2127,
        "y" : 824
      } ]
    } ],
    "catalysts" : [ {
      "id" : 100364,
      "points" : [ {
        "x" : 1966,
        "y" : 798
      }, {
        "x" : 2006,
        "y" : 781
      } ]
    } ]
  }, {
    "id" : 100367,
    "reactomeId" : 10541266,
    "displayName" : "AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1554,
      "y" : 1473
    },
    "minX" : 1488,
    "maxX" : 1586,
    "minY" : 1467,
    "maxY" : 1479,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1488,
        "y" : 1470
      },
      "to" : {
        "x" : 1554,
        "y" : 1473
      }
    }, {
      "from" : {
        "x" : 1554,
        "y" : 1473
      },
      "to" : {
        "x" : 1586,
        "y" : 1472
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1548,
        "y" : 1467
      },
      "b" : {
        "x" : 1560,
        "y" : 1479
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1554,
        "y" : 1473
      }
    },
    "inputs" : [ {
      "id" : 100368
    } ],
    "outputs" : [ {
      "id" : 100369,
      "points" : [ {
        "x" : 1655,
        "y" : 1471
      } ]
    }, {
      "id" : 100370,
      "points" : [ {
        "x" : 1627,
        "y" : 1512
      } ]
    } ],
    "catalysts" : [ {
      "id" : 100368,
      "points" : [ {
        "x" : 1488,
        "y" : 1447
      }, {
        "x" : 1521,
        "y" : 1436
      } ]
    } ]
  }, {
    "id" : 100430,
    "reactomeId" : 10549211,
    "displayName" : "ub UBXN7 is degraded by the 26S proteasome",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 3104,
      "y" : 1025
    },
    "minX" : 2847,
    "maxX" : 3110,
    "minY" : 1008,
    "maxY" : 1053,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 3053,
        "y" : 1053
      },
      "to" : {
        "x" : 3104,
        "y" : 1025
      }
    }, {
      "from" : {
        "x" : 3104,
        "y" : 1025
      },
      "to" : {
        "x" : 3000,
        "y" : 1008
      }
    }, {
      "from" : {
        "x" : 3000,
        "y" : 1008
      },
      "to" : {
        "x" : 2847,
        "y" : 1014
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 2854,
        "y" : 1010
      },
      "b" : {
        "x" : 2847,
        "y" : 1014
      },
      "c" : {
        "x" : 2854,
        "y" : 1018
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 2854,
        "y" : 1018
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 3098,
        "y" : 1019
      },
      "b" : {
        "x" : 3110,
        "y" : 1031
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 3104,
        "y" : 1025
      }
    },
    "inputs" : [ {
      "id" : 100428
    } ],
    "outputs" : [ {
      "id" : 100427
    } ],
    "catalysts" : [ {
      "id" : 100431,
      "points" : [ {
        "x" : 3233,
        "y" : 1092
      } ]
    } ]
  }, {
    "id" : 100432,
    "reactomeId" : 10549202,
    "displayName" : "26S proteasome degrades HIFalpha",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 3590,
      "y" : 876
    },
    "minX" : 3542,
    "maxX" : 3627,
    "minY" : 870,
    "maxY" : 882,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 3542,
        "y" : 871
      },
      "to" : {
        "x" : 3590,
        "y" : 876
      }
    }, {
      "from" : {
        "x" : 3590,
        "y" : 876
      },
      "to" : {
        "x" : 3627,
        "y" : 873
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 3584,
        "y" : 870
      },
      "b" : {
        "x" : 3596,
        "y" : 882
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 3590,
        "y" : 876
      }
    },
    "inputs" : [ {
      "id" : 100413
    } ],
    "outputs" : [ {
      "id" : 100407,
      "points" : [ {
        "x" : 2694,
        "y" : 862
      }, {
        "x" : 2752,
        "y" : 766
      }, {
        "x" : 3663,
        "y" : 755
      } ]
    }, {
      "id" : 100433,
      "points" : [ {
        "x" : 3663,
        "y" : 906
      } ]
    } ],
    "catalysts" : [ {
      "id" : 100431,
      "points" : [ {
        "x" : 3270,
        "y" : 1092
      } ]
    } ]
  }, {
    "id" : 100371,
    "reactomeId" : 10541557,
    "displayName" : "CAND1 binds cytosolic CRL E3 ubiquitin ligases",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 652,
      "y" : 1171
    },
    "minX" : 607,
    "maxX" : 695,
    "minY" : 1165,
    "maxY" : 1177,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 607,
        "y" : 1170
      },
      "to" : {
        "x" : 652,
        "y" : 1171
      }
    }, {
      "from" : {
        "x" : 652,
        "y" : 1171
      },
      "to" : {
        "x" : 695,
        "y" : 1174
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 688,
        "y" : 1178
      },
      "b" : {
        "x" : 695,
        "y" : 1174
      },
      "c" : {
        "x" : 688,
        "y" : 1170
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 688,
        "y" : 1170
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 652,
        "y" : 1171
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 652,
        "y" : 1171
      }
    },
    "inputs" : [ {
      "id" : 100372,
      "points" : [ {
        "x" : 499,
        "y" : 1194
      } ]
    }, {
      "id" : 100373,
      "points" : [ {
        "x" : 548,
        "y" : 1145
      } ]
    } ],
    "outputs" : [ {
      "id" : 100374
    } ]
  }, {
    "id" : 100434,
    "reactomeId" : 10549216,
    "displayName" : "KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 3063,
      "y" : 1417
    },
    "minX" : 3019,
    "maxX" : 3220,
    "minY" : 1411,
    "maxY" : 1423,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 3019,
        "y" : 1415
      },
      "to" : {
        "x" : 3063,
        "y" : 1417
      }
    }, {
      "from" : {
        "x" : 3063,
        "y" : 1417
      },
      "to" : {
        "x" : 3220,
        "y" : 1415
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 3213,
        "y" : 1419
      },
      "b" : {
        "x" : 3220,
        "y" : 1415
      },
      "c" : {
        "x" : 3213,
        "y" : 1411
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 3213,
        "y" : 1411
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 3057,
        "y" : 1411
      },
      "b" : {
        "x" : 3069,
        "y" : 1423
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 3063,
        "y" : 1417
      }
    },
    "inputs" : [ {
      "id" : 100435,
      "points" : [ {
        "x" : 2974,
        "y" : 1411
      } ]
    }, {
      "id" : 100436,
      "points" : [ {
        "x" : 2995,
        "y" : 1312
      } ],
      "stoichiometry" : 3
    } ],
    "outputs" : [ {
      "id" : 100437
    } ],
    "catalysts" : [ {
      "id" : 100435,
      "points" : [ {
        "x" : 2954,
        "y" : 1433
      }, {
        "x" : 3015,
        "y" : 1459
      } ]
    } ],
    "inhibitors" : [ {
      "id" : 100438,
      "points" : [ {
        "x" : 3057,
        "y" : 1380
      } ]
    }, {
      "id" : 100439,
      "points" : [ {
        "x" : 3122,
        "y" : 1455
      } ]
    } ]
  }, {
    "id" : 100375,
    "reactomeId" : 10541571,
    "displayName" : "COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 976,
      "y" : 1174
    },
    "minX" : 889,
    "maxX" : 1028,
    "minY" : 1168,
    "maxY" : 1180,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 889,
        "y" : 1175
      },
      "to" : {
        "x" : 976,
        "y" : 1174
      }
    }, {
      "from" : {
        "x" : 976,
        "y" : 1174
      },
      "to" : {
        "x" : 1028,
        "y" : 1172
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 970,
        "y" : 1168
      },
      "b" : {
        "x" : 982,
        "y" : 1180
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 976,
        "y" : 1174
      }
    },
    "inputs" : [ {
      "id" : 100374,
      "points" : [ {
        "x" : 802,
        "y" : 1177
      } ]
    }, {
      "id" : 100376,
      "points" : [ {
        "x" : 742,
        "y" : 1239
      } ]
    } ],
    "outputs" : [ {
      "id" : 100373,
      "points" : [ {
        "x" : 554,
        "y" : 1130
      }, {
        "x" : 967,
        "y" : 1121
      } ]
    }, {
      "id" : 100377,
      "points" : [ {
        "x" : 1072,
        "y" : 1176
      } ]
    } ]
  }, {
    "id" : 100440,
    "reactomeId" : 10549315,
    "displayName" : "UBXN7 binds VCP hexamer:UBF1:NPLOC4",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2930,
      "y" : 1333
    },
    "minX" : 2763,
    "maxX" : 3077,
    "minY" : 1327,
    "maxY" : 1339,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 2763,
        "y" : 1332
      },
      "to" : {
        "x" : 2930,
        "y" : 1333
      }
    }, {
      "from" : {
        "x" : 2930,
        "y" : 1333
      },
      "to" : {
        "x" : 3077,
        "y" : 1329
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 3070,
        "y" : 1333
      },
      "b" : {
        "x" : 3077,
        "y" : 1329
      },
      "c" : {
        "x" : 3070,
        "y" : 1325
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 3070,
        "y" : 1325
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 2930,
        "y" : 1333
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 2930,
        "y" : 1333
      }
    },
    "inputs" : [ {
      "id" : 100441,
      "points" : [ {
        "x" : 2682,
        "y" : 1333
      } ]
    }, {
      "id" : 100426,
      "points" : [ {
        "x" : 2733,
        "y" : 998
      } ]
    } ],
    "outputs" : [ {
      "id" : 100442
    } ]
  }, {
    "id" : 100443,
    "reactomeId" : 10549229,
    "displayName" : "UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 3317,
      "y" : 1335
    },
    "minX" : 3252,
    "maxX" : 3361,
    "minY" : 1329,
    "maxY" : 1341,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 3252,
        "y" : 1329
      },
      "to" : {
        "x" : 3317,
        "y" : 1335
      }
    }, {
      "from" : {
        "x" : 3317,
        "y" : 1335
      },
      "to" : {
        "x" : 3361,
        "y" : 1333
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 3354,
        "y" : 1337
      },
      "b" : {
        "x" : 3361,
        "y" : 1333
      },
      "c" : {
        "x" : 3354,
        "y" : 1329
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 3354,
        "y" : 1329
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 3317,
        "y" : 1335
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 3317,
        "y" : 1335
      }
    },
    "inputs" : [ {
      "id" : 100442,
      "points" : [ {
        "x" : 3203,
        "y" : 1328
      } ]
    }, {
      "id" : 100437,
      "points" : [ {
        "x" : 3277,
        "y" : 1394
      } ]
    } ],
    "outputs" : [ {
      "id" : 100444
    } ]
  }, {
    "id" : 100378,
    "reactomeId" : 10541563,
    "displayName" : "CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 763,
      "y" : 1470
    },
    "minX" : 743,
    "maxX" : 794,
    "minY" : 1464,
    "maxY" : 1476,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 743,
        "y" : 1470
      },
      "to" : {
        "x" : 763,
        "y" : 1470
      }
    }, {
      "from" : {
        "x" : 763,
        "y" : 1470
      },
      "to" : {
        "x" : 794,
        "y" : 1470
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 787,
        "y" : 1474
      },
      "b" : {
        "x" : 794,
        "y" : 1470
      },
      "c" : {
        "x" : 787,
        "y" : 1466
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 787,
        "y" : 1466
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 763,
        "y" : 1470
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 763,
        "y" : 1470
      }
    },
    "inputs" : [ {
      "id" : 100379,
      "points" : [ {
        "x" : 704,
        "y" : 1466
      } ]
    }, {
      "id" : 100380,
      "points" : [ {
        "x" : 697,
        "y" : 1524
      } ]
    } ],
    "outputs" : [ {
      "id" : 100381
    } ]
  }, {
    "id" : 100445,
    "reactomeId" : 10541677,
    "displayName" : "VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2990,
      "y" : 959
    },
    "minX" : 2818,
    "maxX" : 3163,
    "minY" : 953,
    "maxY" : 972,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 2818,
        "y" : 959
      },
      "to" : {
        "x" : 2990,
        "y" : 959
      }
    }, {
      "from" : {
        "x" : 2990,
        "y" : 959
      },
      "to" : {
        "x" : 3163,
        "y" : 972
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 3156,
        "y" : 975
      },
      "b" : {
        "x" : 3163,
        "y" : 972
      },
      "c" : {
        "x" : 3156,
        "y" : 967
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 3156,
        "y" : 967
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 2990,
        "y" : 959
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 2990,
        "y" : 959
      }
    },
    "inputs" : [ {
      "id" : 100426,
      "points" : [ {
        "x" : 2767,
        "y" : 974
      } ]
    }, {
      "id" : 100407,
      "points" : [ {
        "x" : 2746,
        "y" : 930
      } ]
    } ],
    "outputs" : [ {
      "id" : 100414
    } ],
    "inhibitors" : [ {
      "id" : 100429,
      "points" : [ {
        "x" : 2877,
        "y" : 1116
      } ]
    } ]
  }, {
    "id" : 100446,
    "reactomeId" : 10538107,
    "displayName" : "26S proteasome degrades Ub-NFE2L2",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 3267,
      "y" : 1232
    },
    "minX" : 3012,
    "maxX" : 3664,
    "minY" : 1226,
    "maxY" : 1325,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 3664,
        "y" : 1325
      },
      "to" : {
        "x" : 3561,
        "y" : 1245
      }
    }, {
      "from" : {
        "x" : 3561,
        "y" : 1245
      },
      "to" : {
        "x" : 3267,
        "y" : 1232
      }
    }, {
      "from" : {
        "x" : 3267,
        "y" : 1232
      },
      "to" : {
        "x" : 3012,
        "y" : 1292
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 3018,
        "y" : 1287
      },
      "b" : {
        "x" : 3012,
        "y" : 1292
      },
      "c" : {
        "x" : 3020,
        "y" : 1294
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 3020,
        "y" : 1294
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 3261,
        "y" : 1226
      },
      "b" : {
        "x" : 3273,
        "y" : 1238
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 3267,
        "y" : 1232
      }
    },
    "inputs" : [ {
      "id" : 100447
    } ],
    "outputs" : [ {
      "id" : 100436
    } ],
    "catalysts" : [ {
      "id" : 100431,
      "points" : [ {
        "x" : 3255,
        "y" : 1120
      } ]
    } ]
  }, {
    "id" : 100382,
    "reactomeId" : 10541565,
    "displayName" : "COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 990,
      "y" : 1466
    },
    "minX" : 963,
    "maxX" : 1037,
    "minY" : 1460,
    "maxY" : 1472,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 963,
        "y" : 1467
      },
      "to" : {
        "x" : 990,
        "y" : 1466
      }
    }, {
      "from" : {
        "x" : 990,
        "y" : 1466
      },
      "to" : {
        "x" : 1037,
        "y" : 1463
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 984,
        "y" : 1460
      },
      "b" : {
        "x" : 996,
        "y" : 1472
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 990,
        "y" : 1466
      }
    },
    "inputs" : [ {
      "id" : 100383,
      "points" : [ {
        "x" : 947,
        "y" : 1498
      } ]
    }, {
      "id" : 100381,
      "points" : [ {
        "x" : 937,
        "y" : 1468
      } ]
    } ],
    "outputs" : [ {
      "id" : 100380,
      "points" : [ {
        "x" : 720,
        "y" : 1539
      }, {
        "x" : 1069,
        "y" : 1555
      } ]
    }, {
      "id" : 100384,
      "points" : [ {
        "x" : 1086,
        "y" : 1461
      } ]
    } ]
  }, {
    "id" : 100385,
    "reactomeId" : 10541656,
    "displayName" : "COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2907,
      "y" : 668
    },
    "minX" : 2829,
    "maxX" : 2951,
    "minY" : 662,
    "maxY" : 674,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 2829,
        "y" : 671
      },
      "to" : {
        "x" : 2907,
        "y" : 668
      }
    }, {
      "from" : {
        "x" : 2907,
        "y" : 668
      },
      "to" : {
        "x" : 2951,
        "y" : 667
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 2901,
        "y" : 662
      },
      "b" : {
        "x" : 2913,
        "y" : 674
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 2907,
        "y" : 668
      }
    },
    "inputs" : [ {
      "id" : 100386
    } ],
    "outputs" : [ {
      "id" : 100362,
      "points" : [ {
        "x" : 536,
        "y" : 396
      }, {
        "x" : 1008,
        "y" : 174
      }, {
        "x" : 2787,
        "y" : 164
      } ]
    }, {
      "id" : 100387,
      "points" : [ {
        "x" : 3007,
        "y" : 667
      } ]
    } ],
    "catalysts" : [ {
      "id" : 100388,
      "points" : [ {
        "x" : 2876,
        "y" : 629
      } ]
    } ]
  }, {
    "id" : 100389,
    "reactomeId" : 10541663,
    "displayName" : "COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1881,
      "y" : 1473
    },
    "minX" : 1810,
    "maxX" : 1959,
    "minY" : 1467,
    "maxY" : 1479,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1810,
        "y" : 1471
      },
      "to" : {
        "x" : 1881,
        "y" : 1473
      }
    }, {
      "from" : {
        "x" : 1881,
        "y" : 1473
      },
      "to" : {
        "x" : 1959,
        "y" : 1476
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1875,
        "y" : 1467
      },
      "b" : {
        "x" : 1887,
        "y" : 1479
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1881,
        "y" : 1473
      }
    },
    "inputs" : [ {
      "id" : 100369
    } ],
    "outputs" : [ {
      "id" : 100390,
      "points" : [ {
        "x" : 2004,
        "y" : 1476
      } ]
    }, {
      "id" : 100391,
      "points" : [ {
        "x" : 2007,
        "y" : 1548
      } ]
    } ],
    "catalysts" : [ {
      "id" : 100392,
      "points" : [ {
        "x" : 1883,
        "y" : 1515
      } ]
    } ]
  }, {
    "id" : 100393,
    "reactomeId" : 10541638,
    "displayName" : "NEDD8:AcM-UBE2M binds CUL9:RBX1 ubiquitin ligase complex",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1744,
      "y" : 1195
    },
    "minX" : 1706,
    "maxX" : 1782,
    "minY" : 1189,
    "maxY" : 1201,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 1706,
        "y" : 1196
      },
      "to" : {
        "x" : 1744,
        "y" : 1195
      }
    }, {
      "from" : {
        "x" : 1744,
        "y" : 1195
      },
      "to" : {
        "x" : 1782,
        "y" : 1195
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1775,
        "y" : 1199
      },
      "b" : {
        "x" : 1782,
        "y" : 1195
      },
      "c" : {
        "x" : 1775,
        "y" : 1191
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1775,
        "y" : 1191
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1744,
        "y" : 1195
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1744,
        "y" : 1195
      }
    },
    "inputs" : [ {
      "id" : 100394,
      "points" : [ {
        "x" : 1467,
        "y" : 692
      } ]
    }, {
      "id" : 100395,
      "points" : [ {
        "x" : 1631,
        "y" : 1229
      } ]
    } ],
    "outputs" : [ {
      "id" : 100396
    } ]
  }, {
    "id" : 100397,
    "reactomeId" : 10541617,
    "displayName" : "AcM-UBE2M transfers NEDD8 to CUL9:RBX1",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2028,
      "y" : 1210
    },
    "minX" : 1923,
    "maxX" : 2063,
    "minY" : 1201,
    "maxY" : 1216,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1923,
        "y" : 1201
      },
      "to" : {
        "x" : 2028,
        "y" : 1210
      }
    }, {
      "from" : {
        "x" : 2028,
        "y" : 1210
      },
      "to" : {
        "x" : 2063,
        "y" : 1204
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 2022,
        "y" : 1204
      },
      "b" : {
        "x" : 2034,
        "y" : 1216
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 2028,
        "y" : 1210
      }
    },
    "inputs" : [ {
      "id" : 100396
    } ],
    "outputs" : [ {
      "id" : 100365,
      "points" : [ {
        "x" : 899,
        "y" : 727
      }, {
        "x" : 1460,
        "y" : 1277
      }, {
        "x" : 2070,
        "y" : 1277
      } ]
    }, {
      "id" : 100398,
      "points" : [ {
        "x" : 2119,
        "y" : 1201
      } ]
    } ],
    "catalysts" : [ {
      "id" : 100396,
      "points" : [ {
        "x" : 1923,
        "y" : 1180
      }, {
        "x" : 1982,
        "y" : 1167
      } ]
    } ]
  }, {
    "id" : 100399,
    "reactomeId" : 10541635,
    "displayName" : "CUL9:RBX1 ubiquitinates BIRC5",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2380,
      "y" : 1195
    },
    "minX" : 2369,
    "maxX" : 2430,
    "minY" : 1186,
    "maxY" : 1245,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 2369,
        "y" : 1245
      },
      "to" : {
        "x" : 2380,
        "y" : 1195
      }
    }, {
      "from" : {
        "x" : 2380,
        "y" : 1195
      },
      "to" : {
        "x" : 2430,
        "y" : 1186
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 2424,
        "y" : 1191
      },
      "b" : {
        "x" : 2430,
        "y" : 1186
      },
      "c" : {
        "x" : 2422,
        "y" : 1183
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 2422,
        "y" : 1183
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 2374,
        "y" : 1189
      },
      "b" : {
        "x" : 2386,
        "y" : 1201
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 2380,
        "y" : 1195
      }
    },
    "inputs" : [ {
      "id" : 100400,
      "points" : [ {
        "x" : 2375,
        "y" : 1287
      } ],
      "stoichiometry" : 3
    }, {
      "id" : 100401,
      "points" : [ {
        "x" : 2340,
        "y" : 1249
      } ]
    } ],
    "outputs" : [ {
      "id" : 100402
    } ],
    "catalysts" : [ {
      "id" : 100398,
      "points" : [ {
        "x" : 2265,
        "y" : 1196
      } ]
    } ],
    "inhibitors" : [ {
      "id" : 100403,
      "points" : [ {
        "x" : 2452,
        "y" : 1144
      } ]
    } ]
  }, {
    "id" : 100404,
    "reactomeId" : 10541665,
    "displayName" : "NEDD8-CUL9:RBX1 binds CUL7:CCDC8:OBSL1",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2350,
      "y" : 1124
    },
    "minX" : 2321,
    "maxX" : 2411,
    "minY" : 1118,
    "maxY" : 1134,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 2321,
        "y" : 1134
      },
      "to" : {
        "x" : 2350,
        "y" : 1124
      }
    }, {
      "from" : {
        "x" : 2350,
        "y" : 1124
      },
      "to" : {
        "x" : 2411,
        "y" : 1123
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 2404,
        "y" : 1127
      },
      "b" : {
        "x" : 2411,
        "y" : 1123
      },
      "c" : {
        "x" : 2404,
        "y" : 1119
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 2404,
        "y" : 1119
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 2350,
        "y" : 1124
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 2350,
        "y" : 1124
      }
    },
    "inputs" : [ {
      "id" : 100398,
      "points" : [ {
        "x" : 2228,
        "y" : 1177
      } ]
    }, {
      "id" : 100405,
      "points" : [ {
        "x" : 2262,
        "y" : 1133
      } ]
    } ],
    "outputs" : [ {
      "id" : 100403
    } ]
  }, {
    "id" : 100406,
    "reactomeId" : 10541682,
    "displayName" : "VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2883,
      "y" : 874
    },
    "minX" : 2841,
    "maxX" : 2915,
    "minY" : 868,
    "maxY" : 880,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 2841,
        "y" : 877
      },
      "to" : {
        "x" : 2883,
        "y" : 874
      }
    }, {
      "from" : {
        "x" : 2883,
        "y" : 874
      },
      "to" : {
        "x" : 2915,
        "y" : 871
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 2908,
        "y" : 876
      },
      "b" : {
        "x" : 2915,
        "y" : 871
      },
      "c" : {
        "x" : 2908,
        "y" : 868
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 2908,
        "y" : 868
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 2883,
        "y" : 874
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 2883,
        "y" : 874
      }
    },
    "inputs" : [ {
      "id" : 100407,
      "points" : [ {
        "x" : 2764,
        "y" : 886
      } ]
    }, {
      "id" : 100408,
      "points" : [ {
        "x" : 2813,
        "y" : 848
      } ]
    } ],
    "outputs" : [ {
      "id" : 100409
    } ]
  }, {
    "id" : 100410,
    "reactomeId" : 10541687,
    "displayName" : "VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 3259,
      "y" : 857
    },
    "minX" : 3216,
    "maxX" : 3294,
    "minY" : 851,
    "maxY" : 863,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 3216,
        "y" : 855
      },
      "to" : {
        "x" : 3259,
        "y" : 857
      }
    }, {
      "from" : {
        "x" : 3259,
        "y" : 857
      },
      "to" : {
        "x" : 3294,
        "y" : 855
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 3253,
        "y" : 851
      },
      "b" : {
        "x" : 3265,
        "y" : 863
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 3259,
        "y" : 857
      }
    },
    "inputs" : [ {
      "id" : 100411,
      "points" : [ {
        "x" : 3152,
        "y" : 902
      } ]
    }, {
      "id" : 100409,
      "points" : [ {
        "x" : 3136,
        "y" : 858
      } ]
    } ],
    "outputs" : [ {
      "id" : 100412,
      "points" : [ {
        "x" : 3323,
        "y" : 798
      } ]
    }, {
      "id" : 100413,
      "points" : [ {
        "x" : 3340,
        "y" : 857
      } ]
    } ],
    "catalysts" : [ {
      "id" : 100409,
      "points" : [ {
        "x" : 3093,
        "y" : 831
      }, {
        "x" : 3233,
        "y" : 776
      } ]
    } ],
    "inhibitors" : [ {
      "id" : 100414,
      "points" : [ {
        "x" : 3251,
        "y" : 948
      } ]
    } ]
  }, {
    "id" : 100415,
    "reactomeId" : 10541702,
    "displayName" : "NEDD8 and UBD bind NUB1 and the 26S proteasome",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 505,
      "y" : 200
    },
    "minX" : 475,
    "maxX" : 544,
    "minY" : 194,
    "maxY" : 206,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 475,
        "y" : 203
      },
      "to" : {
        "x" : 505,
        "y" : 200
      }
    }, {
      "from" : {
        "x" : 505,
        "y" : 200
      },
      "to" : {
        "x" : 544,
        "y" : 200
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 537,
        "y" : 204
      },
      "b" : {
        "x" : 544,
        "y" : 200
      },
      "c" : {
        "x" : 537,
        "y" : 196
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 537,
        "y" : 196
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 505,
        "y" : 200
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 505,
        "y" : 200
      }
    },
    "inputs" : [ {
      "id" : 100416,
      "points" : [ {
        "x" : 393,
        "y" : 225
      } ]
    }, {
      "id" : 100417,
      "points" : [ {
        "x" : 404,
        "y" : 180
      } ]
    }, {
      "id" : 100418,
      "points" : [ {
        "x" : 403,
        "y" : 134
      } ]
    } ],
    "outputs" : [ {
      "id" : 100419
    } ]
  } ],
  "compartments" : [ {
    "id" : 100448,
    "reactomeId" : 70101,
    "displayName" : "cytosol",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 2092,
      "y" : 1222
    },
    "minX" : 0,
    "maxX" : 4184,
    "minY" : 22,
    "maxY" : 2422,
    "prop" : {
      "x" : 0,
      "y" : 22,
      "width" : 4184,
      "height" : 2400
    },
    "textPosition" : {
      "x" : 728,
      "y" : 861
    },
    "insets" : {
      "x" : 10,
      "y" : 32,
      "width" : 4164,
      "height" : 2380
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 100355, 100356, 100357, 100358, 100359, 100360, 100361, 100362, 100365, 100363, 100394, 100456, 100459, 100371, 100373, 100374, 100375, 100372, 100377, 100464, 100475, 100465, 100476, 100466, 100477, 100422, 100478, 100376, 100385, 100388, 100386, 100479, 100480, 100481, 100482, 100393, 100395, 100396, 100397, 100398, 100399, 100400, 100401, 100402, 100403, 100404, 100405, 100406, 100412, 100413, 100414, 100426, 100415, 100416, 100483, 100417, 100418, 100419, 100408, 100420, 100421, 100423, 100424, 100425, 100428, 100430, 100431, 100366, 100364, 100407, 100467, 100409, 100410, 100411, 100387, 100432, 100433, 100468, 100469, 100435, 100434, 100437, 100438, 100440, 100441, 100442, 100443, 100444, 100436, 100439, 100427, 100445, 100471, 100484, 100485, 100447, 100446 ]
  }, {
    "id" : 100467,
    "reactomeId" : 17927,
    "displayName" : "mitochondrial intermembrane space",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 2913,
      "y" : 1195
    },
    "minX" : 2779,
    "maxX" : 3047,
    "minY" : 1137,
    "maxY" : 1253,
    "prop" : {
      "x" : 2779,
      "y" : 1137,
      "width" : 268,
      "height" : 116
    },
    "textPosition" : {
      "x" : 2794,
      "y" : 1156
    },
    "insets" : {
      "x" : 2789,
      "y" : 1147,
      "width" : 248,
      "height" : 96
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 100429 ]
  }, {
    "id" : 100459,
    "reactomeId" : 7660,
    "displayName" : "nucleoplasm",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 1443,
      "y" : 1599
    },
    "minX" : 375,
    "maxX" : 2512,
    "minY" : 1404,
    "maxY" : 1794,
    "prop" : {
      "x" : 375,
      "y" : 1404,
      "width" : 2137,
      "height" : 390
    },
    "textPosition" : {
      "x" : 1221,
      "y" : 1623
    },
    "insets" : {
      "x" : 385,
      "y" : 1414,
      "width" : 2117,
      "height" : 370
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 100368, 100367, 100370, 100369, 100379, 100378, 100381, 100380, 100382, 100384, 100383, 100389, 100392, 100391, 100390 ]
  } ],
  "notes" : [ ],
  "links" : [ {
    "id" : 100480,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 2338,
      "y" : 537
    },
    "minX" : 2016,
    "maxX" : 2661,
    "minY" : 428,
    "maxY" : 647,
    "segments" : [ {
      "from" : {
        "x" : 2016,
        "y" : 428
      },
      "to" : {
        "x" : 2661,
        "y" : 647
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 2332,
        "y" : 531
      },
      "b" : {
        "x" : 2344,
        "y" : 543
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 2338,
        "y" : 537
      }
    },
    "inputs" : [ {
      "id" : 100456
    } ],
    "outputs" : [ {
      "id" : 100386
    } ]
  }, {
    "id" : 100483,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 436,
      "y" : 327
    },
    "minX" : 371,
    "maxX" : 502,
    "minY" : 259,
    "maxY" : 396,
    "segments" : [ {
      "from" : {
        "x" : 502,
        "y" : 396
      },
      "to" : {
        "x" : 371,
        "y" : 259
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 430,
        "y" : 321
      },
      "b" : {
        "x" : 442,
        "y" : 333
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 436,
        "y" : 327
      }
    },
    "inputs" : [ {
      "id" : 100362
    } ],
    "outputs" : [ {
      "id" : 100416
    } ]
  }, {
    "id" : 100485,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 2655,
      "y" : 1531
    },
    "minX" : 2639,
    "maxX" : 2671,
    "minY" : 1521,
    "maxY" : 1541,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 2639,
        "y" : 1521
      },
      "to" : {
        "x" : 2671,
        "y" : 1541
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 2663,
        "y" : 1541
      },
      "b" : {
        "x" : 2671,
        "y" : 1541
      },
      "c" : {
        "x" : 2667,
        "y" : 1534
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 2667,
        "y" : 1534
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 2649,
        "y" : 1525
      },
      "b" : {
        "x" : 2661,
        "y" : 1537
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 2655,
        "y" : 1531
      }
    },
    "inputs" : [ {
      "id" : 100471
    } ],
    "outputs" : [ {
      "id" : 100469
    } ]
  }, {
    "id" : 100484,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 2653,
      "y" : 1451
    },
    "minX" : 2642,
    "maxX" : 2664,
    "minY" : 1445,
    "maxY" : 1457,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 2642,
        "y" : 1457
      },
      "to" : {
        "x" : 2664,
        "y" : 1445
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 2660,
        "y" : 1452
      },
      "b" : {
        "x" : 2664,
        "y" : 1445
      },
      "c" : {
        "x" : 2656,
        "y" : 1445
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 2656,
        "y" : 1445
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 2647,
        "y" : 1445
      },
      "b" : {
        "x" : 2659,
        "y" : 1457
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 2653,
        "y" : 1451
      }
    },
    "inputs" : [ {
      "id" : 100471
    } ],
    "outputs" : [ {
      "id" : 100468
    } ]
  }, {
    "id" : 100475,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 1242,
      "y" : 721
    },
    "minX" : 1148,
    "maxX" : 1336,
    "minY" : 287,
    "maxY" : 1155,
    "segments" : [ {
      "from" : {
        "x" : 1336,
        "y" : 287
      },
      "to" : {
        "x" : 1148,
        "y" : 1155
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1236,
        "y" : 715
      },
      "b" : {
        "x" : 1248,
        "y" : 727
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1242,
        "y" : 721
      }
    },
    "inputs" : [ {
      "id" : 100464
    } ],
    "outputs" : [ {
      "id" : 100377
    } ]
  }, {
    "id" : 100477,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 1304,
      "y" : 1014
    },
    "minX" : 1165,
    "maxX" : 1444,
    "minY" : 873,
    "maxY" : 1155,
    "segments" : [ {
      "from" : {
        "x" : 1444,
        "y" : 873
      },
      "to" : {
        "x" : 1165,
        "y" : 1155
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1298,
        "y" : 1008
      },
      "b" : {
        "x" : 1310,
        "y" : 1020
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1304,
        "y" : 1014
      }
    },
    "inputs" : [ {
      "id" : 100466
    } ],
    "outputs" : [ {
      "id" : 100377
    } ]
  }, {
    "id" : 100476,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 1260,
      "y" : 1118
    },
    "minX" : 1186,
    "maxX" : 1335,
    "minY" : 1081,
    "maxY" : 1155,
    "segments" : [ {
      "from" : {
        "x" : 1335,
        "y" : 1081
      },
      "to" : {
        "x" : 1186,
        "y" : 1155
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1254,
        "y" : 1112
      },
      "b" : {
        "x" : 1266,
        "y" : 1124
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1260,
        "y" : 1118
      }
    },
    "inputs" : [ {
      "id" : 100465
    } ],
    "outputs" : [ {
      "id" : 100377
    } ]
  }, {
    "id" : 100479,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 2460,
      "y" : 750
    },
    "minX" : 2260,
    "maxX" : 2661,
    "minY" : 695,
    "maxY" : 806,
    "segments" : [ {
      "from" : {
        "x" : 2260,
        "y" : 806
      },
      "to" : {
        "x" : 2661,
        "y" : 695
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 2454,
        "y" : 744
      },
      "b" : {
        "x" : 2466,
        "y" : 756
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 2460,
        "y" : 750
      }
    },
    "inputs" : [ {
      "id" : 100366
    } ],
    "outputs" : [ {
      "id" : 100386
    } ]
  }, {
    "id" : 100478,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 1369,
      "y" : 872
    },
    "minX" : 1160,
    "maxX" : 1578,
    "minY" : 589,
    "maxY" : 1155,
    "segments" : [ {
      "from" : {
        "x" : 1578,
        "y" : 589
      },
      "to" : {
        "x" : 1160,
        "y" : 1155
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1363,
        "y" : 866
      },
      "b" : {
        "x" : 1375,
        "y" : 878
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1369,
        "y" : 872
      }
    },
    "inputs" : [ {
      "id" : 100422
    } ],
    "outputs" : [ {
      "id" : 100377
    } ]
  } ],
  "shadows" : [ ],
  "minX" : 0,
  "maxX" : 4184,
  "minY" : 0,
  "maxY" : 2422,
  "disease" : false
}