{
  "dbId" : 10557763,
  "stableId" : "R-SSC-1474228",
  "displayName" : "Degradation of the extracellular matrix",
  "nodes" : [ {
    "id" : 138114,
    "reactomeId" : 10508679,
    "displayName" : "BCAN",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1724,
      "y" : 218
    },
    "minX" : 1625,
    "maxX" : 1786,
    "minY" : 201,
    "maxY" : 229,
    "prop" : {
      "x" : 1668,
      "y" : 207,
      "width" : 112,
      "height" : 22
    },
    "textPosition" : {
      "x" : 1703,
      "y" : 207
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1780,
          "y" : 207
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1780,
          "y" : 207
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 138112,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1662,
          "y" : 215
        },
        "to" : {
          "x" : 1625,
          "y" : 214
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1655,
          "y" : 219
        },
        "b" : {
          "x" : 1662,
          "y" : 215
        },
        "c" : {
          "x" : 1655,
          "y" : 211
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1655,
          "y" : 211
        }
      }
    } ]
  }, {
    "id" : 138115,
    "reactomeId" : 10508703,
    "displayName" : "MMP1, 2, 3, 7,8,10,13,19",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1580,
      "y" : 278
    },
    "minX" : 1514,
    "maxX" : 1646,
    "minY" : 216,
    "maxY" : 296,
    "prop" : {
      "x" : 1514,
      "y" : 260,
      "width" : 132,
      "height" : 36
    },
    "textPosition" : {
      "x" : 1536,
      "y" : 260
    },
    "connectors" : [ {
      "edgeId" : 138112,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 1580,
          "y" : 254
        },
        "to" : {
          "x" : 1581,
          "y" : 224
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1581,
          "y" : 220
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1581,
          "y" : 220
        }
      }
    } ]
  }, {
    "id" : 138113,
    "reactomeId" : 10508691,
    "displayName" : "BCAN",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1723,
      "y" : 262
    },
    "minX" : 1625,
    "maxX" : 1789,
    "minY" : 214,
    "maxY" : 273,
    "prop" : {
      "x" : 1663,
      "y" : 251,
      "width" : 120,
      "height" : 22
    },
    "textPosition" : {
      "x" : 1702,
      "y" : 251
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1783,
          "y" : 251
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1783,
          "y" : 251
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 138112,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1700,
          "y" : 245
        },
        "to" : {
          "x" : 1625,
          "y" : 214
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1692,
          "y" : 246
        },
        "b" : {
          "x" : 1700,
          "y" : 245
        },
        "c" : {
          "x" : 1695,
          "y" : 239
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1695,
          "y" : 239
        }
      }
    } ]
  }, {
    "id" : 138118,
    "reactomeId" : 10504679,
    "displayName" : "DCN",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 501,
      "y" : 62
    },
    "minX" : 433,
    "maxX" : 543,
    "minY" : 45,
    "maxY" : 115,
    "prop" : {
      "x" : 466,
      "y" : 51,
      "width" : 71,
      "height" : 22
    },
    "textPosition" : {
      "x" : 484,
      "y" : 51
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 537,
          "y" : 51
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 537,
          "y" : 51
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 138116,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 474,
          "y" : 76
        },
        "to" : {
          "x" : 433,
          "y" : 90
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 469,
          "y" : 82
        },
        "b" : {
          "x" : 474,
          "y" : 76
        },
        "c" : {
          "x" : 466,
          "y" : 74
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 466,
          "y" : 74
        }
      }
    }, {
      "edgeId" : 138121,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 486,
          "y" : 76
        },
        "to" : {
          "x" : 433,
          "y" : 115
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 483,
          "y" : 83
        },
        "b" : {
          "x" : 486,
          "y" : 76
        },
        "c" : {
          "x" : 478,
          "y" : 77
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 478,
          "y" : 77
        }
      }
    } ]
  }, {
    "id" : 138119,
    "reactomeId" : 10504681,
    "displayName" : "DCN",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 504,
      "y" : 145
    },
    "minX" : 433,
    "maxX" : 555,
    "minY" : 90,
    "maxY" : 156,
    "prop" : {
      "x" : 460,
      "y" : 135,
      "width" : 89,
      "height" : 21
    },
    "textPosition" : {
      "x" : 487,
      "y" : 135
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 549,
          "y" : 135
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 549,
          "y" : 135
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 138116,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 490,
          "y" : 132
        },
        "to" : {
          "x" : 433,
          "y" : 90
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 482,
          "y" : 131
        },
        "b" : {
          "x" : 490,
          "y" : 132
        },
        "c" : {
          "x" : 487,
          "y" : 125
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 487,
          "y" : 125
        }
      }
    }, {
      "edgeId" : 138121,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 479,
          "y" : 132
        },
        "to" : {
          "x" : 433,
          "y" : 115
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 471,
          "y" : 133
        },
        "b" : {
          "x" : 479,
          "y" : 132
        },
        "c" : {
          "x" : 474,
          "y" : 126
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 474,
          "y" : 126
        }
      }
    } ]
  }, {
    "id" : 138117,
    "reactomeId" : 10503374,
    "displayName" : "DCN",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 347,
      "y" : 99
    },
    "minX" : 330,
    "maxX" : 371,
    "minY" : 82,
    "maxY" : 110,
    "prop" : {
      "x" : 330,
      "y" : 88,
      "width" : 35,
      "height" : 22
    },
    "textPosition" : {
      "x" : 330,
      "y" : 88
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 365,
          "y" : 88
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 365,
          "y" : 88
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 138116,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 138121,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 138123,
    "reactomeId" : 10457225,
    "displayName" : "A2M tetramer",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 88,
      "y" : 1115
    },
    "minX" : 41,
    "maxX" : 141,
    "minY" : 1079,
    "maxY" : 1127,
    "prop" : {
      "x" : 41,
      "y" : 1104,
      "width" : 94,
      "height" : 23
    },
    "textPosition" : {
      "x" : 41,
      "y" : 1106
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 135,
          "y" : 1104
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 135,
          "y" : 1104
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 138122,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 95,
          "y" : 1101
        },
        "to" : {
          "x" : 113,
          "y" : 1079
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 138120,
    "reactomeId" : 10504683,
    "displayName" : "MMP2, MMP3, MMP7",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 402,
      "y" : 28
    },
    "minX" : 368,
    "maxX" : 437,
    "minY" : 4,
    "maxY" : 79,
    "prop" : {
      "x" : 368,
      "y" : 4,
      "width" : 69,
      "height" : 49
    },
    "textPosition" : {
      "x" : 376,
      "y" : 4
    },
    "connectors" : [ {
      "edgeId" : 138116,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 402,
          "y" : 59
        },
        "to" : {
          "x" : 402,
          "y" : 71
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 403,
          "y" : 75
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 403,
          "y" : 75
        }
      }
    } ]
  }, {
    "id" : 138127,
    "reactomeId" : 10491910,
    "displayName" : "MMP2, MMP7, MMP9",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1180,
      "y" : 391
    },
    "minX" : 1131,
    "maxX" : 1256,
    "minY" : 373,
    "maxY" : 420,
    "prop" : {
      "x" : 1131,
      "y" : 373,
      "width" : 99,
      "height" : 36
    },
    "textPosition" : {
      "x" : 1132,
      "y" : 373
    },
    "connectors" : [ {
      "edgeId" : 138126,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1227,
          "y" : 415
        },
        "to" : {
          "x" : 1256,
          "y" : 420
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 138124,
    "reactomeId" : 10491900,
    "displayName" : "MMP1, 3, 13, (2, 7-12, 19)",
    "schemaClass" : "CandidateSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 59,
      "y" : 1038
    },
    "minX" : 11,
    "maxX" : 113,
    "minY" : 1021,
    "maxY" : 1079,
    "prop" : {
      "x" : 11,
      "y" : 1021,
      "width" : 97,
      "height" : 34
    },
    "textPosition" : {
      "x" : 13,
      "y" : 1021
    },
    "connectors" : [ {
      "edgeId" : 138122,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 81,
          "y" : 1061
        },
        "to" : {
          "x" : 113,
          "y" : 1079
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 138125,
    "reactomeId" : 10491902,
    "displayName" : "Alpha 2-macroglobulin:MMP1, 3, 13, (2, 7-12, 19)",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 295,
      "y" : 1078
    },
    "minX" : 208,
    "maxX" : 389,
    "minY" : 1053,
    "maxY" : 1098,
    "prop" : {
      "x" : 208,
      "y" : 1059,
      "width" : 175,
      "height" : 39
    },
    "textPosition" : {
      "x" : 210,
      "y" : 1063
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 383,
          "y" : 1059
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 383,
          "y" : 1059
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 138122,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 138131,
    "reactomeId" : 10470032,
    "displayName" : "SPP1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1226,
      "y" : 329
    },
    "minX" : 1204,
    "maxX" : 1254,
    "minY" : 312,
    "maxY" : 340,
    "prop" : {
      "x" : 1204,
      "y" : 318,
      "width" : 44,
      "height" : 22
    },
    "textPosition" : {
      "x" : 1206,
      "y" : 318
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1248,
          "y" : 318
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1248,
          "y" : 318
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 138130,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 138128,
    "reactomeId" : 10491908,
    "displayName" : "CD44",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1181,
      "y" : 438
    },
    "minX" : 1158,
    "maxX" : 1256,
    "minY" : 420,
    "maxY" : 449,
    "prop" : {
      "x" : 1158,
      "y" : 427,
      "width" : 46,
      "height" : 22
    },
    "textPosition" : {
      "x" : 1160,
      "y" : 427
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1204,
          "y" : 427
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1204,
          "y" : 427
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 138126,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1207,
          "y" : 432
        },
        "to" : {
          "x" : 1256,
          "y" : 420
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 138129,
    "reactomeId" : 10491912,
    "displayName" : "CD44:MMP2, MMP7, MMP9",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1358,
      "y" : 441
    },
    "minX" : 1313,
    "maxX" : 1410,
    "minY" : 417,
    "maxY" : 459,
    "prop" : {
      "x" : 1313,
      "y" : 423,
      "width" : 91,
      "height" : 36
    },
    "textPosition" : {
      "x" : 1314,
      "y" : 424
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1404,
          "y" : 423
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1404,
          "y" : 423
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 138126,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 138134,
    "reactomeId" : 10509657,
    "displayName" : "MMP3, MMP7",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1290,
      "y" : 270
    },
    "minX" : 1245,
    "maxX" : 1336,
    "minY" : 259,
    "maxY" : 320,
    "prop" : {
      "x" : 1245,
      "y" : 259,
      "width" : 91,
      "height" : 22
    },
    "textPosition" : {
      "x" : 1246,
      "y" : 259
    },
    "connectors" : [ {
      "edgeId" : 138130,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 1290,
          "y" : 287
        },
        "to" : {
          "x" : 1291,
          "y" : 312
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1291,
          "y" : 316
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1291,
          "y" : 316
        }
      }
    } ]
  }, {
    "id" : 138132,
    "reactomeId" : 10509655,
    "displayName" : "SPP1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1394,
      "y" : 300
    },
    "minX" : 1323,
    "maxX" : 1447,
    "minY" : 283,
    "maxY" : 328,
    "prop" : {
      "x" : 1348,
      "y" : 289,
      "width" : 93,
      "height" : 22
    },
    "textPosition" : {
      "x" : 1374,
      "y" : 289
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1441,
          "y" : 289
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1441,
          "y" : 289
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 138130,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1366,
          "y" : 314
        },
        "to" : {
          "x" : 1323,
          "y" : 328
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1361,
          "y" : 320
        },
        "b" : {
          "x" : 1366,
          "y" : 314
        },
        "c" : {
          "x" : 1358,
          "y" : 312
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1358,
          "y" : 312
        }
      }
    } ]
  }, {
    "id" : 138133,
    "reactomeId" : 10509653,
    "displayName" : "SPP1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1390,
      "y" : 352
    },
    "minX" : 1323,
    "maxX" : 1438,
    "minY" : 328,
    "maxY" : 363,
    "prop" : {
      "x" : 1348,
      "y" : 341,
      "width" : 84,
      "height" : 22
    },
    "textPosition" : {
      "x" : 1370,
      "y" : 341
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1432,
          "y" : 341
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1432,
          "y" : 341
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 138130,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1359,
          "y" : 338
        },
        "to" : {
          "x" : 1323,
          "y" : 328
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1351,
          "y" : 340
        },
        "b" : {
          "x" : 1359,
          "y" : 338
        },
        "c" : {
          "x" : 1353,
          "y" : 332
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1353,
          "y" : 332
        }
      }
    } ]
  }, {
    "id" : 138138,
    "reactomeId" : 8848706,
    "displayName" : "substrate protein for calpains",
    "schemaClass" : "OtherEntity",
    "renderableClass" : "Entity",
    "position" : {
      "x" : 889,
      "y" : 495
    },
    "minX" : 835,
    "maxX" : 943,
    "minY" : 476,
    "maxY" : 515,
    "prop" : {
      "x" : 835,
      "y" : 476,
      "width" : 108,
      "height" : 39
    },
    "textPosition" : {
      "x" : 850,
      "y" : 471
    },
    "connectors" : [ {
      "edgeId" : 138137,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 138139,
    "reactomeId" : 8848709,
    "displayName" : "calpain-cleaved protein",
    "schemaClass" : "OtherEntity",
    "renderableClass" : "Entity",
    "position" : {
      "x" : 890,
      "y" : 638
    },
    "minX" : 840,
    "maxX" : 940,
    "minY" : 577,
    "maxY" : 658,
    "prop" : {
      "x" : 840,
      "y" : 619,
      "width" : 100,
      "height" : 39
    },
    "textPosition" : {
      "x" : 860,
      "y" : 614
    },
    "connectors" : [ {
      "edgeId" : 138137,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 883,
            "y" : 577
          },
          "b" : {
            "x" : 895,
            "y" : 589
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 889,
            "y" : 583
          }
        }
      }
    } ]
  }, {
    "id" : 138136,
    "reactomeId" : 10509860,
    "displayName" : "ADAM10, ADAM15",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 575,
      "y" : 500
    },
    "minX" : 494,
    "maxX" : 610,
    "minY" : 482,
    "maxY" : 570,
    "prop" : {
      "x" : 541,
      "y" : 482,
      "width" : 69,
      "height" : 36
    },
    "textPosition" : {
      "x" : 542,
      "y" : 482
    },
    "connectors" : [ {
      "edgeId" : 138135,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 553,
          "y" : 524
        },
        "to" : {
          "x" : 501,
          "y" : 563
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 498,
          "y" : 566
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 498,
          "y" : 566
        }
      }
    } ]
  }, {
    "id" : 138142,
    "reactomeId" : 10533002,
    "displayName" : "Homologues of CAST",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 834,
      "y" : 550
    },
    "minX" : 813,
    "maxX" : 880,
    "minY" : 539,
    "maxY" : 561,
    "prop" : {
      "x" : 813,
      "y" : 539,
      "width" : 43,
      "height" : 22
    },
    "textPosition" : {
      "x" : 813,
      "y" : 519
    },
    "connectors" : [ {
      "edgeId" : 138137,
      "type" : "INHIBITOR",
      "segments" : [ {
        "from" : {
          "x" : 859,
          "y" : 550
        },
        "to" : {
          "x" : 880,
          "y" : 550
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 880,
          "y" : 554
        },
        "b" : {
          "x" : 880,
          "y" : 546
        },
        "c" : {
          "x" : 880,
          "y" : 550
        },
        "type" : "STOP",
        "centre" : {
          "x" : 880,
          "y" : 550
        }
      }
    } ]
  }, {
    "id" : 138140,
    "reactomeId" : 10532991,
    "displayName" : "CAPN:4xCa2+:CAPNS",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 972,
      "y" : 551
    },
    "minX" : 897,
    "maxX" : 1027,
    "minY" : 527,
    "maxY" : 569,
    "prop" : {
      "x" : 924,
      "y" : 533,
      "width" : 97,
      "height" : 36
    },
    "textPosition" : {
      "x" : 924,
      "y" : 534
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1021,
          "y" : 533
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1021,
          "y" : 533
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 138137,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 921,
          "y" : 550
        },
        "to" : {
          "x" : 905,
          "y" : 550
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 901,
          "y" : 550
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 901,
          "y" : 550
        }
      }
    } ]
  }, {
    "id" : 138141,
    "reactomeId" : 74016,
    "displayName" : "Ca2+",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 999,
      "y" : 495
    },
    "minX" : 897,
    "maxX" : 1022,
    "minY" : 479,
    "maxY" : 546,
    "prop" : {
      "x" : 978,
      "y" : 480,
      "width" : 43,
      "height" : 30
    },
    "textPosition" : {
      "x" : 978,
      "y" : 484
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1016,
          "y" : 485
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1016,
          "y" : 485
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 138137,
      "type" : "ACTIVATOR",
      "segments" : [ {
        "from" : {
          "x" : 975,
          "y" : 505
        },
        "to" : {
          "x" : 897,
          "y" : 546
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 901,
          "y" : 539
        },
        "b" : {
          "x" : 897,
          "y" : 546
        },
        "c" : {
          "x" : 905,
          "y" : 546
        },
        "type" : "ARROW",
        "empty" : true,
        "centre" : {
          "x" : 905,
          "y" : 546
        }
      }
    } ]
  }, {
    "id" : 138146,
    "reactomeId" : 10534694,
    "displayName" : "ACAN(17-375)",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 679,
      "y" : 1050
    },
    "minX" : 576,
    "maxX" : 733,
    "minY" : 1037,
    "maxY" : 1073,
    "prop" : {
      "x" : 626,
      "y" : 1037,
      "width" : 107,
      "height" : 27
    },
    "textPosition" : {
      "x" : 632,
      "y" : 1040
    },
    "connectors" : [ {
      "edgeId" : 138143,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 620,
          "y" : 1061
        },
        "to" : {
          "x" : 576,
          "y" : 1073
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 614,
          "y" : 1067
        },
        "b" : {
          "x" : 620,
          "y" : 1061
        },
        "c" : {
          "x" : 612,
          "y" : 1059
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 612,
          "y" : 1059
        }
      }
    } ]
  }, {
    "id" : 138147,
    "reactomeId" : 10534702,
    "displayName" : "ACAN(376-2415)",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 679,
      "y" : 1101
    },
    "minX" : 576,
    "maxX" : 739,
    "minY" : 1073,
    "maxY" : 1116,
    "prop" : {
      "x" : 619,
      "y" : 1086,
      "width" : 120,
      "height" : 30
    },
    "textPosition" : {
      "x" : 623,
      "y" : 1090
    },
    "connectors" : [ {
      "edgeId" : 138143,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 623,
          "y" : 1080
        },
        "to" : {
          "x" : 576,
          "y" : 1073
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 616,
          "y" : 1083
        },
        "b" : {
          "x" : 623,
          "y" : 1080
        },
        "c" : {
          "x" : 617,
          "y" : 1075
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 617,
          "y" : 1075
        }
      }
    } ]
  }, {
    "id" : 138144,
    "reactomeId" : 10503332,
    "displayName" : "Aggrecan",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 422,
      "y" : 930
    },
    "minX" : 389,
    "maxX" : 482,
    "minY" : 919,
    "maxY" : 1074,
    "prop" : {
      "x" : 389,
      "y" : 919,
      "width" : 66,
      "height" : 22
    },
    "textPosition" : {
      "x" : 392,
      "y" : 913
    },
    "connectors" : [ {
      "edgeId" : 138143,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 426,
          "y" : 947
        },
        "to" : {
          "x" : 482,
          "y" : 1074
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 138145,
    "reactomeId" : 109276,
    "displayName" : "H2O",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 433,
      "y" : 1101
    },
    "minX" : 412,
    "maxX" : 482,
    "minY" : 1074,
    "maxY" : 1117,
    "prop" : {
      "x" : 412,
      "y" : 1086,
      "width" : 43,
      "height" : 31
    },
    "textPosition" : {
      "x" : 416,
      "y" : 1091
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 450,
          "y" : 1091
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 450,
          "y" : 1091
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 138143,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 458,
          "y" : 1089
        },
        "to" : {
          "x" : 482,
          "y" : 1074
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ],
    "trivial" : true
  }, {
    "id" : 138150,
    "reactomeId" : 10539310,
    "displayName" : "OPTC",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1279,
      "y" : 942
    },
    "minX" : 1256,
    "maxX" : 1309,
    "minY" : 925,
    "maxY" : 953,
    "prop" : {
      "x" : 1256,
      "y" : 931,
      "width" : 47,
      "height" : 22
    },
    "textPosition" : {
      "x" : 1259,
      "y" : 931
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1303,
          "y" : 931
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1303,
          "y" : 931
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 138149,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 138155,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 138158,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 138151,
    "reactomeId" : 10539316,
    "displayName" : "OPTC",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1681,
      "y" : 937
    },
    "minX" : 1394,
    "maxX" : 1739,
    "minY" : 861,
    "maxY" : 1063,
    "prop" : {
      "x" : 1629,
      "y" : 926,
      "width" : 104,
      "height" : 22
    },
    "textPosition" : {
      "x" : 1661,
      "y" : 926
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1733,
          "y" : 926
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1733,
          "y" : 926
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 138149,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1639,
          "y" : 923
        },
        "to" : {
          "x" : 1394,
          "y" : 861
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1631,
          "y" : 925
        },
        "b" : {
          "x" : 1639,
          "y" : 923
        },
        "c" : {
          "x" : 1633,
          "y" : 917
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1633,
          "y" : 917
        }
      }
    }, {
      "edgeId" : 138155,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1660,
          "y" : 951
        },
        "to" : {
          "x" : 1449,
          "y" : 1063
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1656,
          "y" : 958
        },
        "b" : {
          "x" : 1660,
          "y" : 951
        },
        "c" : {
          "x" : 1652,
          "y" : 951
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1652,
          "y" : 951
        }
      }
    }, {
      "edgeId" : 138158,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1626,
          "y" : 938
        },
        "to" : {
          "x" : 1409,
          "y" : 946
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1619,
          "y" : 942
        },
        "b" : {
          "x" : 1626,
          "y" : 938
        },
        "c" : {
          "x" : 1619,
          "y" : 934
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1619,
          "y" : 934
        }
      }
    } ]
  }, {
    "id" : 138148,
    "reactomeId" : 10534708,
    "displayName" : "HTRA1 trimer",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 533,
      "y" : 1131
    },
    "minX" : 496,
    "maxX" : 576,
    "minY" : 1082,
    "maxY" : 1151,
    "prop" : {
      "x" : 496,
      "y" : 1111,
      "width" : 74,
      "height" : 40
    },
    "textPosition" : {
      "x" : 507,
      "y" : 1116
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 570,
          "y" : 1111
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 570,
          "y" : 1111
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 138143,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 533,
          "y" : 1108
        },
        "to" : {
          "x" : 533,
          "y" : 1090
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 533,
          "y" : 1086
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 533,
          "y" : 1086
        }
      }
    } ]
  }, {
    "id" : 138154,
    "reactomeId" : 10491867,
    "displayName" : "MMP2(110-660)",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1337,
      "y" : 816
    },
    "minX" : 1283,
    "maxX" : 1397,
    "minY" : 798,
    "maxY" : 855,
    "prop" : {
      "x" : 1283,
      "y" : 804,
      "width" : 108,
      "height" : 25
    },
    "textPosition" : {
      "x" : 1284,
      "y" : 806
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1391,
          "y" : 804
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1391,
          "y" : 804
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 138149,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 1344,
          "y" : 832
        },
        "to" : {
          "x" : 1356,
          "y" : 848
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1358,
          "y" : 851
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1358,
          "y" : 851
        }
      }
    } ]
  }, {
    "id" : 138152,
    "reactomeId" : 10539312,
    "displayName" : "OPTC",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1477,
      "y" : 845
    },
    "minX" : 1394,
    "maxX" : 1528,
    "minY" : 828,
    "maxY" : 861,
    "prop" : {
      "x" : 1432,
      "y" : 834,
      "width" : 90,
      "height" : 22
    },
    "textPosition" : {
      "x" : 1457,
      "y" : 834
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1522,
          "y" : 834
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1522,
          "y" : 834
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 138149,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1429,
          "y" : 853
        },
        "to" : {
          "x" : 1394,
          "y" : 861
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1423,
          "y" : 858
        },
        "b" : {
          "x" : 1429,
          "y" : 853
        },
        "c" : {
          "x" : 1421,
          "y" : 851
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1421,
          "y" : 851
        }
      }
    } ]
  }, {
    "id" : 138153,
    "reactomeId" : 10539314,
    "displayName" : "OPTC",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1482,
      "y" : 917
    },
    "minX" : 1394,
    "maxX" : 1541,
    "minY" : 861,
    "maxY" : 946,
    "prop" : {
      "x" : 1429,
      "y" : 907,
      "width" : 106,
      "height" : 21
    },
    "textPosition" : {
      "x" : 1462,
      "y" : 907
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1535,
          "y" : 907
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1535,
          "y" : 907
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 138149,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1465,
          "y" : 904
        },
        "to" : {
          "x" : 1394,
          "y" : 861
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1457,
          "y" : 904
        },
        "b" : {
          "x" : 1465,
          "y" : 904
        },
        "c" : {
          "x" : 1461,
          "y" : 897
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1461,
          "y" : 897
        }
      }
    }, {
      "edgeId" : 138158,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1455,
          "y" : 931
        },
        "to" : {
          "x" : 1409,
          "y" : 946
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1450,
          "y" : 937
        },
        "b" : {
          "x" : 1455,
          "y" : 931
        },
        "c" : {
          "x" : 1447,
          "y" : 929
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1447,
          "y" : 929
        }
      }
    } ]
  }, {
    "id" : 138159,
    "reactomeId" : 10539321,
    "displayName" : "OPTC",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1486,
      "y" : 967
    },
    "minX" : 1409,
    "maxX" : 1539,
    "minY" : 946,
    "maxY" : 978,
    "prop" : {
      "x" : 1440,
      "y" : 956,
      "width" : 93,
      "height" : 22
    },
    "textPosition" : {
      "x" : 1466,
      "y" : 956
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1533,
          "y" : 956
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1533,
          "y" : 956
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 138158,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1445,
          "y" : 953
        },
        "to" : {
          "x" : 1409,
          "y" : 946
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1437,
          "y" : 956
        },
        "b" : {
          "x" : 1445,
          "y" : 953
        },
        "c" : {
          "x" : 1439,
          "y" : 948
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1439,
          "y" : 948
        }
      }
    } ]
  }, {
    "id" : 138156,
    "reactomeId" : 10539480,
    "displayName" : "OPTC",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1537,
      "y" : 1096
    },
    "minX" : 1449,
    "maxX" : 1591,
    "minY" : 1063,
    "maxY" : 1107,
    "prop" : {
      "x" : 1489,
      "y" : 1085,
      "width" : 96,
      "height" : 22
    },
    "textPosition" : {
      "x" : 1517,
      "y" : 1085
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1585,
          "y" : 1085
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1585,
          "y" : 1085
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 138155,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1507,
          "y" : 1082
        },
        "to" : {
          "x" : 1449,
          "y" : 1063
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1499,
          "y" : 1084
        },
        "b" : {
          "x" : 1507,
          "y" : 1082
        },
        "c" : {
          "x" : 1502,
          "y" : 1076
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1502,
          "y" : 1076
        }
      }
    } ]
  }, {
    "id" : 138157,
    "reactomeId" : 10491863,
    "displayName" : "MMP13",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1312,
      "y" : 1067
    },
    "minX" : 1286,
    "maxX" : 1391,
    "minY" : 1050,
    "maxY" : 1078,
    "prop" : {
      "x" : 1286,
      "y" : 1056,
      "width" : 52,
      "height" : 22
    },
    "textPosition" : {
      "x" : 1286,
      "y" : 1056
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1338,
          "y" : 1056
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1338,
          "y" : 1056
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 138155,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 1341,
          "y" : 1065
        },
        "to" : {
          "x" : 1383,
          "y" : 1064
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1387,
          "y" : 1063
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1387,
          "y" : 1063
        }
      }
    } ]
  }, {
    "id" : 138163,
    "reactomeId" : 10539619,
    "displayName" : "SCUBE3",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1377,
      "y" : 690
    },
    "minX" : 1349,
    "maxX" : 1411,
    "minY" : 673,
    "maxY" : 701,
    "prop" : {
      "x" : 1349,
      "y" : 679,
      "width" : 56,
      "height" : 22
    },
    "textPosition" : {
      "x" : 1352,
      "y" : 673
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1405,
          "y" : 679
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1405,
          "y" : 679
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 138162,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 138160,
    "reactomeId" : 10539323,
    "displayName" : "OPTC",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1434,
      "y" : 1002
    },
    "minX" : 1387,
    "maxX" : 1487,
    "minY" : 946,
    "maxY" : 1017,
    "prop" : {
      "x" : 1387,
      "y" : 987,
      "width" : 94,
      "height" : 30
    },
    "textPosition" : {
      "x" : 1414,
      "y" : 991
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1481,
          "y" : 987
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1481,
          "y" : 987
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 138158,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1427,
          "y" : 984
        },
        "to" : {
          "x" : 1409,
          "y" : 946
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1420,
          "y" : 979
        },
        "b" : {
          "x" : 1427,
          "y" : 984
        },
        "c" : {
          "x" : 1428,
          "y" : 976
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1428,
          "y" : 976
        }
      }
    } ]
  }, {
    "id" : 138161,
    "reactomeId" : 10491875,
    "displayName" : "MMP7(95-267)",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1378,
      "y" : 905
    },
    "minX" : 1345,
    "maxX" : 1418,
    "minY" : 886,
    "maxY" : 939,
    "prop" : {
      "x" : 1345,
      "y" : 892,
      "width" : 67,
      "height" : 27
    },
    "textPosition" : {
      "x" : 1347,
      "y" : 888
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1412,
          "y" : 892
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1412,
          "y" : 892
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 138158,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 1376,
          "y" : 922
        },
        "to" : {
          "x" : 1375,
          "y" : 931
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1374,
          "y" : 935
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1374,
          "y" : 935
        }
      }
    } ]
  }, {
    "id" : 138166,
    "reactomeId" : 10509329,
    "displayName" : "MMP2, MMP9",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1435,
      "y" : 778
    },
    "minX" : 1392,
    "maxX" : 1479,
    "minY" : 737,
    "maxY" : 789,
    "prop" : {
      "x" : 1392,
      "y" : 767,
      "width" : 87,
      "height" : 22
    },
    "textPosition" : {
      "x" : 1409,
      "y" : 761
    },
    "connectors" : [ {
      "edgeId" : 138162,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 1434,
          "y" : 761
        },
        "to" : {
          "x" : 1434,
          "y" : 745
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1434,
          "y" : 741
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1434,
          "y" : 741
        }
      }
    } ]
  }, {
    "id" : 138164,
    "reactomeId" : 10539621,
    "displayName" : "SCUBE3",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1473,
      "y" : 691
    },
    "minX" : 1426,
    "maxX" : 1526,
    "minY" : 674,
    "maxY" : 729,
    "prop" : {
      "x" : 1426,
      "y" : 680,
      "width" : 94,
      "height" : 22
    },
    "textPosition" : {
      "x" : 1444,
      "y" : 680
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1520,
          "y" : 680
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1520,
          "y" : 680
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 138162,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1472,
          "y" : 705
        },
        "to" : {
          "x" : 1470,
          "y" : 729
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1475,
          "y" : 712
        },
        "b" : {
          "x" : 1472,
          "y" : 705
        },
        "c" : {
          "x" : 1467,
          "y" : 712
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1467,
          "y" : 712
        }
      }
    } ]
  }, {
    "id" : 138165,
    "reactomeId" : 10539623,
    "displayName" : "SCUBE3",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1593,
      "y" : 692
    },
    "minX" : 1470,
    "maxX" : 1651,
    "minY" : 675,
    "maxY" : 729,
    "prop" : {
      "x" : 1541,
      "y" : 681,
      "width" : 104,
      "height" : 22
    },
    "textPosition" : {
      "x" : 1564,
      "y" : 681
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1645,
          "y" : 681
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1645,
          "y" : 681
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 138162,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1556,
          "y" : 706
        },
        "to" : {
          "x" : 1470,
          "y" : 729
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1550,
          "y" : 712
        },
        "b" : {
          "x" : 1556,
          "y" : 706
        },
        "c" : {
          "x" : 1548,
          "y" : 704
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1548,
          "y" : 704
        }
      }
    } ]
  }, {
    "id" : 138170,
    "reactomeId" : 10557811,
    "displayName" : "Activation of Matrix Metalloproteinases",
    "schemaClass" : "Pathway",
    "renderableClass" : "ProcessNode",
    "position" : {
      "x" : 70,
      "y" : 32
    },
    "minX" : 0,
    "maxX" : 140,
    "minY" : 4,
    "maxY" : 61,
    "prop" : {
      "x" : 0,
      "y" : 4,
      "width" : 140,
      "height" : 57
    },
    "textPosition" : {
      "x" : 1,
      "y" : 11
    },
    "connectors" : [ ]
  }, {
    "id" : 138171,
    "reactomeId" : 10557761,
    "displayName" : "Collagen degradation",
    "schemaClass" : "Pathway",
    "renderableClass" : "ProcessNode",
    "position" : {
      "x" : 227,
      "y" : 34
    },
    "minX" : 164,
    "maxX" : 290,
    "minY" : 7,
    "maxY" : 61,
    "prop" : {
      "x" : 164,
      "y" : 7,
      "width" : 126,
      "height" : 54
    },
    "textPosition" : {
      "x" : 180,
      "y" : 12
    },
    "connectors" : [ ]
  }, {
    "id" : 138168,
    "reactomeId" : 10539632,
    "displayName" : "SCUBE1,SCUBE3",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1103,
      "y" : 694
    },
    "minX" : 1050,
    "maxX" : 1157,
    "minY" : 683,
    "maxY" : 705,
    "prop" : {
      "x" : 1050,
      "y" : 683,
      "width" : 107,
      "height" : 22
    },
    "textPosition" : {
      "x" : 1073,
      "y" : 677
    },
    "connectors" : [ {
      "edgeId" : 138167,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 138169,
    "reactomeId" : 10539638,
    "displayName" : "SCUBE1,SCUBE3 polymer, SCUBE3 polymer",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1266,
      "y" : 694
    },
    "minX" : 1208,
    "maxX" : 1325,
    "minY" : 669,
    "maxY" : 719,
    "prop" : {
      "x" : 1208,
      "y" : 669,
      "width" : 117,
      "height" : 50
    },
    "textPosition" : {
      "x" : 1208,
      "y" : 669
    },
    "connectors" : [ {
      "edgeId" : 138167,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 138074,
    "reactomeId" : 10493590,
    "displayName" : "Elastin",
    "schemaClass" : "Polymer",
    "renderableClass" : "Entity",
    "position" : {
      "x" : 590,
      "y" : 99
    },
    "minX" : 567,
    "maxX" : 613,
    "minY" : 88,
    "maxY" : 110,
    "prop" : {
      "x" : 567,
      "y" : 88,
      "width" : 46,
      "height" : 22
    },
    "textPosition" : {
      "x" : 569,
      "y" : 82
    },
    "connectors" : [ {
      "edgeId" : 138073,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 138077,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 138075,
    "reactomeId" : 10493598,
    "displayName" : "Cleaved elastin",
    "schemaClass" : "Polymer",
    "renderableClass" : "Entity",
    "position" : {
      "x" : 759,
      "y" : 100
    },
    "minX" : 711,
    "maxX" : 807,
    "minY" : 89,
    "maxY" : 111,
    "prop" : {
      "x" : 711,
      "y" : 89,
      "width" : 96,
      "height" : 22
    },
    "textPosition" : {
      "x" : 728,
      "y" : 83
    },
    "connectors" : [ {
      "edgeId" : 138073,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 138077,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 138078,
    "reactomeId" : 10492177,
    "displayName" : "MMP14,TMPRSS6",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 447,
      "y" : 390
    },
    "minX" : 393,
    "maxX" : 934,
    "minY" : 112,
    "maxY" : 401,
    "prop" : {
      "x" : 393,
      "y" : 379,
      "width" : 109,
      "height" : 22
    },
    "textPosition" : {
      "x" : 415,
      "y" : 373
    },
    "connectors" : [ {
      "edgeId" : 138121,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 445,
          "y" : 373
        },
        "to" : {
          "x" : 406,
          "y" : 132
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 405,
          "y" : 128
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 405,
          "y" : 128
        }
      }
    }, {
      "edgeId" : 138077,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 455,
          "y" : 373
        },
        "to" : {
          "x" : 663,
          "y" : 124
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 665,
          "y" : 121
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 665,
          "y" : 121
        }
      }
    }, {
      "edgeId" : 138094,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 466,
          "y" : 373
        },
        "to" : {
          "x" : 926,
          "y" : 118
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 930,
          "y" : 116
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 930,
          "y" : 116
        }
      }
    } ]
  }, {
    "id" : 138076,
    "reactomeId" : 10493604,
    "displayName" : "Elastin-degrading extracellular proteinases",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 661,
      "y" : 25
    },
    "minX" : 603,
    "maxX" : 719,
    "minY" : 0,
    "maxY" : 79,
    "prop" : {
      "x" : 603,
      "y" : 0,
      "width" : 116,
      "height" : 50
    },
    "textPosition" : {
      "x" : 616,
      "y" : -6
    },
    "connectors" : [ {
      "edgeId" : 138073,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 660,
          "y" : 56
        },
        "to" : {
          "x" : 660,
          "y" : 71
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 660,
          "y" : 75
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 660,
          "y" : 75
        }
      }
    } ]
  }, {
    "id" : 138082,
    "reactomeId" : 10504503,
    "displayName" : "MMP2,9,12,13",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 141,
      "y" : 200
    },
    "minX" : 93,
    "maxX" : 189,
    "minY" : 160,
    "maxY" : 211,
    "prop" : {
      "x" : 93,
      "y" : 189,
      "width" : 96,
      "height" : 22
    },
    "textPosition" : {
      "x" : 93,
      "y" : 189
    },
    "connectors" : [ {
      "edgeId" : 138079,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 140,
          "y" : 183
        },
        "to" : {
          "x" : 140,
          "y" : 168
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 140,
          "y" : 164
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 140,
          "y" : 164
        }
      }
    } ]
  }, {
    "id" : 138080,
    "reactomeId" : 10493771,
    "displayName" : "Fibrillin 1,2,(3)",
    "schemaClass" : "CandidateSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 61,
      "y" : 153
    },
    "minX" : 13,
    "maxX" : 110,
    "minY" : 142,
    "maxY" : 164,
    "prop" : {
      "x" : 13,
      "y" : 142,
      "width" : 97,
      "height" : 22
    },
    "textPosition" : {
      "x" : 13,
      "y" : 142
    },
    "connectors" : [ {
      "edgeId" : 138079,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 138081,
    "reactomeId" : 10504501,
    "displayName" : "Cleaved fibrillin 1,2,(3)",
    "schemaClass" : "CandidateSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 253,
      "y" : 154
    },
    "minX" : 175,
    "maxX" : 331,
    "minY" : 140,
    "maxY" : 169,
    "prop" : {
      "x" : 175,
      "y" : 140,
      "width" : 156,
      "height" : 29
    },
    "textPosition" : {
      "x" : 179,
      "y" : 144
    },
    "connectors" : [ {
      "edgeId" : 138079,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 138086,
    "reactomeId" : 10493621,
    "displayName" : "MMP1, 3, 7, 12, 13, 19, CTSS",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 134,
      "y" : 688
    },
    "minX" : 91,
    "maxX" : 177,
    "minY" : 666,
    "maxY" : 779,
    "prop" : {
      "x" : 91,
      "y" : 666,
      "width" : 86,
      "height" : 45
    },
    "textPosition" : {
      "x" : 92,
      "y" : 664
    },
    "connectors" : [ {
      "edgeId" : 138083,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 139,
          "y" : 717
        },
        "to" : {
          "x" : 155,
          "y" : 771
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 157,
          "y" : 775
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 157,
          "y" : 775
        }
      }
    } ]
  }, {
    "id" : 138084,
    "reactomeId" : 10469681,
    "displayName" : "Fibronectin matrix",
    "schemaClass" : "Polymer",
    "renderableClass" : "Entity",
    "position" : {
      "x" : 59,
      "y" : 817
    },
    "minX" : 3,
    "maxX" : 116,
    "minY" : 806,
    "maxY" : 828,
    "prop" : {
      "x" : 3,
      "y" : 806,
      "width" : 113,
      "height" : 22
    },
    "textPosition" : {
      "x" : 18,
      "y" : 800
    },
    "connectors" : [ {
      "edgeId" : 138083,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 138087,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 138091,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 138089,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 138085,
    "reactomeId" : 10493615,
    "displayName" : "Cleaved fibronectin matrix",
    "schemaClass" : "Polymer",
    "renderableClass" : "Entity",
    "position" : {
      "x" : 300,
      "y" : 823
    },
    "minX" : 238,
    "maxX" : 362,
    "minY" : 805,
    "maxY" : 841,
    "prop" : {
      "x" : 238,
      "y" : 805,
      "width" : 124,
      "height" : 36
    },
    "textPosition" : {
      "x" : 241,
      "y" : 805
    },
    "connectors" : [ {
      "edgeId" : 138083,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 138087,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 138089,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 138090,
    "reactomeId" : 10498969,
    "displayName" : "Homologues of CTSG",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 110,
      "y" : 749
    },
    "minX" : 90,
    "maxX" : 162,
    "minY" : 738,
    "maxY" : 821,
    "prop" : {
      "x" : 90,
      "y" : 738,
      "width" : 40,
      "height" : 22
    },
    "textPosition" : {
      "x" : 90,
      "y" : 711
    },
    "connectors" : [ {
      "edgeId" : 138089,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 117,
          "y" : 763
        },
        "to" : {
          "x" : 155,
          "y" : 814
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 158,
          "y" : 817
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 158,
          "y" : 817
        }
      }
    } ]
  }, {
    "id" : 138088,
    "reactomeId" : 10492171,
    "displayName" : "MMP14",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 222,
      "y" : 747
    },
    "minX" : 178,
    "maxX" : 254,
    "minY" : 730,
    "maxY" : 802,
    "prop" : {
      "x" : 196,
      "y" : 736,
      "width" : 52,
      "height" : 23
    },
    "textPosition" : {
      "x" : 196,
      "y" : 737
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 248,
          "y" : 736
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 248,
          "y" : 736
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 138087,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 212,
          "y" : 762
        },
        "to" : {
          "x" : 184,
          "y" : 795
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 182,
          "y" : 798
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 182,
          "y" : 798
        }
      }
    } ]
  }, {
    "id" : 138095,
    "reactomeId" : 10469643,
    "displayName" : "Laminin-332",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 871,
      "y" : 99
    },
    "minX" : 829,
    "maxX" : 919,
    "minY" : 82,
    "maxY" : 110,
    "prop" : {
      "x" : 829,
      "y" : 88,
      "width" : 84,
      "height" : 22
    },
    "textPosition" : {
      "x" : 829,
      "y" : 89
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 913,
          "y" : 88
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 913,
          "y" : 88
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 138094,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 138092,
    "reactomeId" : 10508592,
    "displayName" : "Cleaved fibronectin matrix Ala(271)/Val(272)",
    "schemaClass" : "Polymer",
    "renderableClass" : "Entity",
    "position" : {
      "x" : 282,
      "y" : 914
    },
    "minX" : 220,
    "maxX" : 344,
    "minY" : 889,
    "maxY" : 939,
    "prop" : {
      "x" : 220,
      "y" : 889,
      "width" : 124,
      "height" : 50
    },
    "textPosition" : {
      "x" : 221,
      "y" : 889
    },
    "connectors" : [ {
      "edgeId" : 138091,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 138093,
    "reactomeId" : 10508596,
    "displayName" : "ADAM8",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 88,
      "y" : 971
    },
    "minX" : 62,
    "maxX" : 120,
    "minY" : 925,
    "maxY" : 982,
    "prop" : {
      "x" : 62,
      "y" : 960,
      "width" : 52,
      "height" : 22
    },
    "textPosition" : {
      "x" : 62,
      "y" : 960
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 114,
          "y" : 960
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 114,
          "y" : 960
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 138091,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 91,
          "y" : 957
        },
        "to" : {
          "x" : 100,
          "y" : 933
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 102,
          "y" : 929
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 102,
          "y" : 929
        }
      }
    } ]
  }, {
    "id" : 138098,
    "reactomeId" : 10508731,
    "displayName" : "CDH1(155-882):Ca2+ dimer",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 546,
      "y" : 438
    },
    "minX" : 487,
    "maxX" : 611,
    "minY" : 414,
    "maxY" : 456,
    "prop" : {
      "x" : 487,
      "y" : 420,
      "width" : 118,
      "height" : 36
    },
    "textPosition" : {
      "x" : 492,
      "y" : 421
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 605,
          "y" : 420
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 605,
          "y" : 420
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 138135,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 138097,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 138099,
    "reactomeId" : 10508735,
    "displayName" : "E-cadherin strand dimer fragment 155-700",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 516,
      "y" : 691
    },
    "minX" : 433,
    "maxX" : 581,
    "minY" : 620,
    "maxY" : 716,
    "prop" : {
      "x" : 457,
      "y" : 666,
      "width" : 118,
      "height" : 50
    },
    "textPosition" : {
      "x" : 467,
      "y" : 653
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 575,
          "y" : 666
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 575,
          "y" : 666
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 138135,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 495,
          "y" : 663
        },
        "to" : {
          "x" : 458,
          "y" : 621
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 487,
          "y" : 660
        },
        "b" : {
          "x" : 495,
          "y" : 663
        },
        "c" : {
          "x" : 493,
          "y" : 655
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 493,
          "y" : 655
        }
      }
    }, {
      "edgeId" : 138097,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 486,
          "y" : 663
        },
        "to" : {
          "x" : 433,
          "y" : 620
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 478,
          "y" : 662
        },
        "b" : {
          "x" : 486,
          "y" : 663
        },
        "c" : {
          "x" : 483,
          "y" : 656
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 483,
          "y" : 656
        }
      }
    } ]
  }, {
    "id" : 138096,
    "reactomeId" : 10508720,
    "displayName" : "Cleaved laminin-332",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1040,
      "y" : 99
    },
    "minX" : 975,
    "maxX" : 1112,
    "minY" : 82,
    "maxY" : 110,
    "prop" : {
      "x" : 975,
      "y" : 88,
      "width" : 131,
      "height" : 22
    },
    "textPosition" : {
      "x" : 986,
      "y" : 75
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1106,
          "y" : 88
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1106,
          "y" : 88
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 138094,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 138103,
    "reactomeId" : 10503895,
    "displayName" : "NID1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1163,
      "y" : 138
    },
    "minX" : 1145,
    "maxX" : 1188,
    "minY" : 121,
    "maxY" : 149,
    "prop" : {
      "x" : 1145,
      "y" : 127,
      "width" : 37,
      "height" : 22
    },
    "textPosition" : {
      "x" : 1145,
      "y" : 127
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1182,
          "y" : 127
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1182,
          "y" : 127
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 138102,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 138100,
    "reactomeId" : 10508739,
    "displayName" : "E-cadherin strand dimer fragment 701-882",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 372,
      "y" : 686
    },
    "minX" : 313,
    "maxX" : 458,
    "minY" : 620,
    "maxY" : 711,
    "prop" : {
      "x" : 313,
      "y" : 661,
      "width" : 118,
      "height" : 50
    },
    "textPosition" : {
      "x" : 323,
      "y" : 648
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 431,
          "y" : 661
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 431,
          "y" : 661
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 138135,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 405,
          "y" : 658
        },
        "to" : {
          "x" : 458,
          "y" : 621
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 408,
          "y" : 651
        },
        "b" : {
          "x" : 405,
          "y" : 658
        },
        "c" : {
          "x" : 413,
          "y" : 657
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 413,
          "y" : 657
        }
      }
    }, {
      "edgeId" : 138097,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 395,
          "y" : 658
        },
        "to" : {
          "x" : 433,
          "y" : 620
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 397,
          "y" : 650
        },
        "b" : {
          "x" : 395,
          "y" : 658
        },
        "c" : {
          "x" : 403,
          "y" : 656
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 403,
          "y" : 656
        }
      }
    } ]
  }, {
    "id" : 138101,
    "reactomeId" : 10508745,
    "displayName" : "MMP9, KLK7",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 262,
      "y" : 561
    },
    "minX" : 220,
    "maxX" : 440,
    "minY" : 543,
    "maxY" : 582,
    "prop" : {
      "x" : 220,
      "y" : 543,
      "width" : 85,
      "height" : 37
    },
    "textPosition" : {
      "x" : 222,
      "y" : 551
    },
    "connectors" : [ {
      "edgeId" : 138097,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 311,
          "y" : 565
        },
        "to" : {
          "x" : 432,
          "y" : 577
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 436,
          "y" : 578
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 436,
          "y" : 578
        }
      }
    } ]
  }, {
    "id" : 138106,
    "reactomeId" : 10491894,
    "displayName" : "MMP19",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1198,
      "y" : 62
    },
    "minX" : 1171,
    "maxX" : 1269,
    "minY" : 45,
    "maxY" : 132,
    "prop" : {
      "x" : 1171,
      "y" : 51,
      "width" : 54,
      "height" : 22
    },
    "textPosition" : {
      "x" : 1172,
      "y" : 51
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1225,
          "y" : 51
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1225,
          "y" : 51
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 138102,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 1209,
          "y" : 76
        },
        "to" : {
          "x" : 1262,
          "y" : 125
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1265,
          "y" : 128
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1265,
          "y" : 128
        }
      }
    } ]
  }, {
    "id" : 138104,
    "reactomeId" : 10508724,
    "displayName" : "NID1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1408,
      "y" : 190
    },
    "minX" : 1308,
    "maxX" : 1456,
    "minY" : 136,
    "maxY" : 201,
    "prop" : {
      "x" : 1367,
      "y" : 179,
      "width" : 83,
      "height" : 22
    },
    "textPosition" : {
      "x" : 1390,
      "y" : 179
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1450,
          "y" : 179
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1450,
          "y" : 179
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 138102,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1387,
          "y" : 176
        },
        "to" : {
          "x" : 1308,
          "y" : 136
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1379,
          "y" : 176
        },
        "b" : {
          "x" : 1387,
          "y" : 176
        },
        "c" : {
          "x" : 1383,
          "y" : 169
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1383,
          "y" : 169
        }
      }
    } ]
  }, {
    "id" : 138105,
    "reactomeId" : 10508726,
    "displayName" : "NID1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1415,
      "y" : 110
    },
    "minX" : 1308,
    "maxX" : 1474,
    "minY" : 93,
    "maxY" : 136,
    "prop" : {
      "x" : 1363,
      "y" : 99,
      "width" : 105,
      "height" : 22
    },
    "textPosition" : {
      "x" : 1397,
      "y" : 99
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1468,
          "y" : 99
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1468,
          "y" : 99
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 138102,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1369,
          "y" : 124
        },
        "to" : {
          "x" : 1308,
          "y" : 136
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1363,
          "y" : 129
        },
        "b" : {
          "x" : 1369,
          "y" : 124
        },
        "c" : {
          "x" : 1361,
          "y" : 121
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1361,
          "y" : 121
        }
      }
    } ]
  }, {
    "id" : 138110,
    "reactomeId" : 10508601,
    "displayName" : "BCAN",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1717,
      "y" : 137
    },
    "minX" : 1621,
    "maxX" : 1779,
    "minY" : 120,
    "maxY" : 162,
    "prop" : {
      "x" : 1661,
      "y" : 126,
      "width" : 112,
      "height" : 22
    },
    "textPosition" : {
      "x" : 1696,
      "y" : 126
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1773,
          "y" : 126
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1773,
          "y" : 126
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 138107,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1674,
          "y" : 154
        },
        "to" : {
          "x" : 1621,
          "y" : 162
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1668,
          "y" : 159
        },
        "b" : {
          "x" : 1674,
          "y" : 154
        },
        "c" : {
          "x" : 1667,
          "y" : 151
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1667,
          "y" : 151
        }
      }
    } ]
  }, {
    "id" : 138111,
    "reactomeId" : 10508633,
    "displayName" : "ADAMTS4, ADAMTS5",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1577,
      "y" : 107
    },
    "minX" : 1540,
    "maxX" : 1615,
    "minY" : 89,
    "maxY" : 155,
    "prop" : {
      "x" : 1540,
      "y" : 89,
      "width" : 75,
      "height" : 36
    },
    "textPosition" : {
      "x" : 1540,
      "y" : 89
    },
    "connectors" : [ {
      "edgeId" : 138107,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 1578,
          "y" : 131
        },
        "to" : {
          "x" : 1580,
          "y" : 147
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1580,
          "y" : 151
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1580,
          "y" : 151
        }
      }
    } ]
  }, {
    "id" : 138108,
    "reactomeId" : 10497818,
    "displayName" : "BCAN",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1522,
      "y" : 182
    },
    "minX" : 1492,
    "maxX" : 1558,
    "minY" : 165,
    "maxY" : 193,
    "prop" : {
      "x" : 1492,
      "y" : 171,
      "width" : 60,
      "height" : 22
    },
    "textPosition" : {
      "x" : 1501,
      "y" : 171
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1552,
          "y" : 171
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1552,
          "y" : 171
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 138112,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 138107,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 138109,
    "reactomeId" : 10508613,
    "displayName" : "BCAN",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1723,
      "y" : 185
    },
    "minX" : 1621,
    "maxX" : 1789,
    "minY" : 162,
    "maxY" : 196,
    "prop" : {
      "x" : 1663,
      "y" : 174,
      "width" : 120,
      "height" : 22
    },
    "textPosition" : {
      "x" : 1702,
      "y" : 174
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1783,
          "y" : 174
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1783,
          "y" : 174
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 138107,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1674,
          "y" : 168
        },
        "to" : {
          "x" : 1621,
          "y" : 162
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1667,
          "y" : 171
        },
        "b" : {
          "x" : 1674,
          "y" : 168
        },
        "c" : {
          "x" : 1668,
          "y" : 163
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1668,
          "y" : 163
        }
      }
    } ]
  } ],
  "edges" : [ {
    "id" : 138112,
    "reactomeId" : 10508706,
    "displayName" : "Brevican degradation by MMP1, 2, 3, 7,8,10,13,19",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1581,
      "y" : 208
    },
    "minX" : 1546,
    "maxX" : 1625,
    "minY" : 199,
    "maxY" : 214,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1546,
        "y" : 199
      },
      "to" : {
        "x" : 1581,
        "y" : 208
      }
    }, {
      "from" : {
        "x" : 1581,
        "y" : 208
      },
      "to" : {
        "x" : 1625,
        "y" : 214
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1575,
        "y" : 202
      },
      "b" : {
        "x" : 1587,
        "y" : 214
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1581,
        "y" : 208
      }
    },
    "inputs" : [ {
      "id" : 138108
    } ],
    "outputs" : [ {
      "id" : 138113,
      "points" : [ {
        "x" : 1700,
        "y" : 245
      } ]
    }, {
      "id" : 138114,
      "points" : [ {
        "x" : 1662,
        "y" : 215
      } ]
    } ],
    "catalysts" : [ {
      "id" : 138115,
      "points" : [ {
        "x" : 1580,
        "y" : 254
      } ]
    } ]
  }, {
    "id" : 138116,
    "reactomeId" : 10504686,
    "displayName" : "DCN (decorin) degradation by MMP2, MMP3, MMP7",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 403,
      "y" : 87
    },
    "minX" : 368,
    "maxX" : 433,
    "minY" : 81,
    "maxY" : 95,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 368,
        "y" : 95
      },
      "to" : {
        "x" : 403,
        "y" : 87
      }
    }, {
      "from" : {
        "x" : 403,
        "y" : 87
      },
      "to" : {
        "x" : 433,
        "y" : 90
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 397,
        "y" : 81
      },
      "b" : {
        "x" : 409,
        "y" : 93
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 403,
        "y" : 87
      }
    },
    "inputs" : [ {
      "id" : 138117
    } ],
    "outputs" : [ {
      "id" : 138118,
      "points" : [ {
        "x" : 474,
        "y" : 76
      } ]
    }, {
      "id" : 138119,
      "points" : [ {
        "x" : 490,
        "y" : 132
      } ]
    } ],
    "catalysts" : [ {
      "id" : 138120,
      "points" : [ {
        "x" : 402,
        "y" : 59
      } ]
    } ]
  }, {
    "id" : 138122,
    "reactomeId" : 10491904,
    "displayName" : "MMP1,3,13 (2, 7-12, 19) binding by Alpha-2 macroglubulin",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 160,
      "y" : 1078
    },
    "minX" : 113,
    "maxX" : 205,
    "minY" : 1072,
    "maxY" : 1084,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 113,
        "y" : 1079
      },
      "to" : {
        "x" : 160,
        "y" : 1078
      }
    }, {
      "from" : {
        "x" : 160,
        "y" : 1078
      },
      "to" : {
        "x" : 205,
        "y" : 1078
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 198,
        "y" : 1082
      },
      "b" : {
        "x" : 205,
        "y" : 1078
      },
      "c" : {
        "x" : 198,
        "y" : 1074
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 198,
        "y" : 1074
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 160,
        "y" : 1078
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 160,
        "y" : 1078
      }
    },
    "inputs" : [ {
      "id" : 138123,
      "points" : [ {
        "x" : 95,
        "y" : 1101
      } ]
    }, {
      "id" : 138124,
      "points" : [ {
        "x" : 81,
        "y" : 1061
      } ]
    } ],
    "outputs" : [ {
      "id" : 138125
    } ]
  }, {
    "id" : 138121,
    "reactomeId" : 10508750,
    "displayName" : "DCN (decorin) degradation by MMP14",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 403,
      "y" : 116
    },
    "minX" : 368,
    "maxX" : 433,
    "minY" : 104,
    "maxY" : 122,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 368,
        "y" : 104
      },
      "to" : {
        "x" : 403,
        "y" : 116
      }
    }, {
      "from" : {
        "x" : 403,
        "y" : 116
      },
      "to" : {
        "x" : 433,
        "y" : 115
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 397,
        "y" : 110
      },
      "b" : {
        "x" : 409,
        "y" : 122
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 403,
        "y" : 116
      }
    },
    "inputs" : [ {
      "id" : 138117
    } ],
    "outputs" : [ {
      "id" : 138118,
      "points" : [ {
        "x" : 486,
        "y" : 76
      } ]
    }, {
      "id" : 138119,
      "points" : [ {
        "x" : 479,
        "y" : 132
      } ]
    } ],
    "catalysts" : [ {
      "id" : 138078,
      "points" : [ {
        "x" : 445,
        "y" : 373
      } ]
    } ]
  }, {
    "id" : 138126,
    "reactomeId" : 10491914,
    "displayName" : "MMP2, MMP7, MMP9 bind CD44",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1280,
      "y" : 420
    },
    "minX" : 1256,
    "maxX" : 1310,
    "minY" : 414,
    "maxY" : 428,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 1256,
        "y" : 420
      },
      "to" : {
        "x" : 1280,
        "y" : 420
      }
    }, {
      "from" : {
        "x" : 1280,
        "y" : 420
      },
      "to" : {
        "x" : 1310,
        "y" : 428
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1302,
        "y" : 430
      },
      "b" : {
        "x" : 1310,
        "y" : 428
      },
      "c" : {
        "x" : 1304,
        "y" : 422
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1304,
        "y" : 422
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1280,
        "y" : 420
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1280,
        "y" : 420
      }
    },
    "inputs" : [ {
      "id" : 138127,
      "points" : [ {
        "x" : 1227,
        "y" : 415
      } ]
    }, {
      "id" : 138128,
      "points" : [ {
        "x" : 1207,
        "y" : 432
      } ]
    } ],
    "outputs" : [ {
      "id" : 138129
    } ]
  }, {
    "id" : 138130,
    "reactomeId" : 10509660,
    "displayName" : "OPN (osteopontin) degradation by MMP3, MMP7",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1291,
      "y" : 328
    },
    "minX" : 1251,
    "maxX" : 1323,
    "minY" : 322,
    "maxY" : 334,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1251,
        "y" : 328
      },
      "to" : {
        "x" : 1291,
        "y" : 328
      }
    }, {
      "from" : {
        "x" : 1291,
        "y" : 328
      },
      "to" : {
        "x" : 1323,
        "y" : 328
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1285,
        "y" : 322
      },
      "b" : {
        "x" : 1297,
        "y" : 334
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1291,
        "y" : 328
      }
    },
    "inputs" : [ {
      "id" : 138131
    } ],
    "outputs" : [ {
      "id" : 138132,
      "points" : [ {
        "x" : 1366,
        "y" : 314
      } ]
    }, {
      "id" : 138133,
      "points" : [ {
        "x" : 1359,
        "y" : 338
      } ]
    } ],
    "catalysts" : [ {
      "id" : 138134,
      "points" : [ {
        "x" : 1290,
        "y" : 287
      } ]
    } ]
  }, {
    "id" : 138135,
    "reactomeId" : 10509863,
    "displayName" : "E-cadherin degradation by ADAM10, ADAM15",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 488,
      "y" : 573
    },
    "minX" : 458,
    "maxX" : 538,
    "minY" : 459,
    "maxY" : 621,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 538,
        "y" : 459
      },
      "to" : {
        "x" : 488,
        "y" : 573
      }
    }, {
      "from" : {
        "x" : 488,
        "y" : 573
      },
      "to" : {
        "x" : 458,
        "y" : 621
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 482,
        "y" : 567
      },
      "b" : {
        "x" : 494,
        "y" : 579
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 488,
        "y" : 573
      }
    },
    "inputs" : [ {
      "id" : 138098
    } ],
    "outputs" : [ {
      "id" : 138099,
      "points" : [ {
        "x" : 495,
        "y" : 663
      } ]
    }, {
      "id" : 138100,
      "points" : [ {
        "x" : 405,
        "y" : 658
      } ]
    } ],
    "catalysts" : [ {
      "id" : 138136,
      "points" : [ {
        "x" : 553,
        "y" : 524
      } ]
    } ]
  }, {
    "id" : 138073,
    "reactomeId" : 10493607,
    "displayName" : "Elastin degradation by elastin-degrading extracellular proteinases",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 660,
      "y" : 87
    },
    "minX" : 616,
    "maxX" : 708,
    "minY" : 81,
    "maxY" : 95,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 616,
        "y" : 95
      },
      "to" : {
        "x" : 660,
        "y" : 87
      }
    }, {
      "from" : {
        "x" : 660,
        "y" : 87
      },
      "to" : {
        "x" : 708,
        "y" : 93
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 701,
        "y" : 96
      },
      "b" : {
        "x" : 708,
        "y" : 93
      },
      "c" : {
        "x" : 702,
        "y" : 88
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 702,
        "y" : 88
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 654,
        "y" : 81
      },
      "b" : {
        "x" : 666,
        "y" : 93
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 660,
        "y" : 87
      }
    },
    "inputs" : [ {
      "id" : 138074
    } ],
    "outputs" : [ {
      "id" : 138075
    } ],
    "catalysts" : [ {
      "id" : 138076,
      "points" : [ {
        "x" : 660,
        "y" : 56
      } ]
    } ]
  }, {
    "id" : 138137,
    "reactomeId" : 10533004,
    "displayName" : "CAPN:4xCa2+:CAPNS cleave cytoskeletal proteins",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 889,
      "y" : 550
    },
    "minX" : 883,
    "maxX" : 895,
    "minY" : 518,
    "maxY" : 616,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 889,
        "y" : 518
      },
      "to" : {
        "x" : 889,
        "y" : 550
      }
    }, {
      "from" : {
        "x" : 889,
        "y" : 550
      },
      "to" : {
        "x" : 889,
        "y" : 616
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 885,
        "y" : 609
      },
      "b" : {
        "x" : 889,
        "y" : 616
      },
      "c" : {
        "x" : 893,
        "y" : 609
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 893,
        "y" : 609
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 883,
        "y" : 544
      },
      "b" : {
        "x" : 895,
        "y" : 556
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 889,
        "y" : 550
      }
    },
    "inputs" : [ {
      "id" : 138138
    } ],
    "outputs" : [ {
      "id" : 138139,
      "stoichiometry" : 2
    } ],
    "catalysts" : [ {
      "id" : 138140,
      "points" : [ {
        "x" : 921,
        "y" : 550
      } ]
    } ],
    "inhibitors" : [ {
      "id" : 138142,
      "points" : [ {
        "x" : 859,
        "y" : 550
      } ]
    } ],
    "activators" : [ {
      "id" : 138141,
      "points" : [ {
        "x" : 975,
        "y" : 505
      } ]
    } ]
  }, {
    "id" : 138143,
    "reactomeId" : 10534711,
    "displayName" : "HTRA1 hydrolyzes ACAN (Aggrecan)",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 533,
      "y" : 1074
    },
    "minX" : 482,
    "maxX" : 576,
    "minY" : 1068,
    "maxY" : 1080,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 482,
        "y" : 1074
      },
      "to" : {
        "x" : 533,
        "y" : 1074
      }
    }, {
      "from" : {
        "x" : 533,
        "y" : 1074
      },
      "to" : {
        "x" : 576,
        "y" : 1073
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 527,
        "y" : 1068
      },
      "b" : {
        "x" : 539,
        "y" : 1080
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 533,
        "y" : 1074
      }
    },
    "inputs" : [ {
      "id" : 138144,
      "points" : [ {
        "x" : 426,
        "y" : 947
      } ]
    }, {
      "id" : 138145,
      "points" : [ {
        "x" : 458,
        "y" : 1089
      } ]
    } ],
    "outputs" : [ {
      "id" : 138146,
      "points" : [ {
        "x" : 620,
        "y" : 1061
      } ]
    }, {
      "id" : 138147,
      "points" : [ {
        "x" : 623,
        "y" : 1080
      } ]
    } ],
    "catalysts" : [ {
      "id" : 138148,
      "points" : [ {
        "x" : 533,
        "y" : 1108
      } ]
    } ]
  }, {
    "id" : 138079,
    "reactomeId" : 10504506,
    "displayName" : "Fibrillin 1, 2,(3) degradation by MMP2, 9, 12 and 13",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 140,
      "y" : 152
    },
    "minX" : 116,
    "maxX" : 169,
    "minY" : 146,
    "maxY" : 158,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 116,
        "y" : 152
      },
      "to" : {
        "x" : 140,
        "y" : 152
      }
    }, {
      "from" : {
        "x" : 140,
        "y" : 152
      },
      "to" : {
        "x" : 169,
        "y" : 152
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 162,
        "y" : 156
      },
      "b" : {
        "x" : 169,
        "y" : 152
      },
      "c" : {
        "x" : 162,
        "y" : 148
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 162,
        "y" : 148
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 134,
        "y" : 146
      },
      "b" : {
        "x" : 146,
        "y" : 158
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 140,
        "y" : 152
      }
    },
    "inputs" : [ {
      "id" : 138080
    } ],
    "outputs" : [ {
      "id" : 138081
    } ],
    "catalysts" : [ {
      "id" : 138082,
      "points" : [ {
        "x" : 140,
        "y" : 183
      } ]
    } ]
  }, {
    "id" : 138077,
    "reactomeId" : 10504584,
    "displayName" : "Elastin degradation by MMP14",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 673,
      "y" : 112
    },
    "minX" : 616,
    "maxX" : 708,
    "minY" : 102,
    "maxY" : 118,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 616,
        "y" : 102
      },
      "to" : {
        "x" : 673,
        "y" : 112
      }
    }, {
      "from" : {
        "x" : 673,
        "y" : 112
      },
      "to" : {
        "x" : 708,
        "y" : 106
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 702,
        "y" : 111
      },
      "b" : {
        "x" : 708,
        "y" : 106
      },
      "c" : {
        "x" : 700,
        "y" : 103
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 700,
        "y" : 103
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 667,
        "y" : 106
      },
      "b" : {
        "x" : 679,
        "y" : 118
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 673,
        "y" : 112
      }
    },
    "inputs" : [ {
      "id" : 138074
    } ],
    "outputs" : [ {
      "id" : 138075
    } ],
    "catalysts" : [ {
      "id" : 138078,
      "points" : [ {
        "x" : 455,
        "y" : 373
      } ]
    } ]
  }, {
    "id" : 138083,
    "reactomeId" : 10493624,
    "displayName" : "Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 160,
      "y" : 786
    },
    "minX" : 94,
    "maxX" : 235,
    "minY" : 780,
    "maxY" : 806,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 94,
        "y" : 803
      },
      "to" : {
        "x" : 160,
        "y" : 786
      }
    }, {
      "from" : {
        "x" : 160,
        "y" : 786
      },
      "to" : {
        "x" : 235,
        "y" : 806
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 227,
        "y" : 808
      },
      "b" : {
        "x" : 235,
        "y" : 806
      },
      "c" : {
        "x" : 229,
        "y" : 800
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 229,
        "y" : 800
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 154,
        "y" : 780
      },
      "b" : {
        "x" : 166,
        "y" : 792
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 160,
        "y" : 786
      }
    },
    "inputs" : [ {
      "id" : 138084
    } ],
    "outputs" : [ {
      "id" : 138085
    } ],
    "catalysts" : [ {
      "id" : 138086,
      "points" : [ {
        "x" : 139,
        "y" : 717
      } ]
    } ]
  }, {
    "id" : 138087,
    "reactomeId" : 10504647,
    "displayName" : "Fibronectin degradation by MMP14",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 174,
      "y" : 807
    },
    "minX" : 119,
    "maxX" : 235,
    "minY" : 801,
    "maxY" : 815,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 119,
        "y" : 812
      },
      "to" : {
        "x" : 174,
        "y" : 807
      }
    }, {
      "from" : {
        "x" : 174,
        "y" : 807
      },
      "to" : {
        "x" : 235,
        "y" : 815
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 228,
        "y" : 818
      },
      "b" : {
        "x" : 235,
        "y" : 815
      },
      "c" : {
        "x" : 229,
        "y" : 810
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 229,
        "y" : 810
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 168,
        "y" : 801
      },
      "b" : {
        "x" : 180,
        "y" : 813
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 174,
        "y" : 807
      }
    },
    "inputs" : [ {
      "id" : 138084
    } ],
    "outputs" : [ {
      "id" : 138085
    } ],
    "catalysts" : [ {
      "id" : 138088,
      "points" : [ {
        "x" : 212,
        "y" : 762
      } ]
    } ]
  }, {
    "id" : 138149,
    "reactomeId" : 10539319,
    "displayName" : "MMP2 cleaves OPTC",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1365,
      "y" : 861
    },
    "minX" : 1290,
    "maxX" : 1394,
    "minY" : 855,
    "maxY" : 928,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1290,
        "y" : 928
      },
      "to" : {
        "x" : 1365,
        "y" : 861
      }
    }, {
      "from" : {
        "x" : 1365,
        "y" : 861
      },
      "to" : {
        "x" : 1394,
        "y" : 861
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1359,
        "y" : 855
      },
      "b" : {
        "x" : 1371,
        "y" : 867
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1365,
        "y" : 861
      }
    },
    "inputs" : [ {
      "id" : 138150
    } ],
    "outputs" : [ {
      "id" : 138151,
      "points" : [ {
        "x" : 1639,
        "y" : 923
      } ]
    }, {
      "id" : 138152,
      "points" : [ {
        "x" : 1429,
        "y" : 853
      } ]
    }, {
      "id" : 138153,
      "points" : [ {
        "x" : 1465,
        "y" : 904
      } ]
    } ],
    "catalysts" : [ {
      "id" : 138154,
      "points" : [ {
        "x" : 1344,
        "y" : 832
      } ]
    } ]
  }, {
    "id" : 138091,
    "reactomeId" : 10508599,
    "displayName" : "Fibronectin degradation by ADAM8",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 106,
      "y" : 918
    },
    "minX" : 64,
    "maxX" : 217,
    "minY" : 831,
    "maxY" : 924,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 64,
        "y" : 831
      },
      "to" : {
        "x" : 106,
        "y" : 918
      }
    }, {
      "from" : {
        "x" : 106,
        "y" : 918
      },
      "to" : {
        "x" : 217,
        "y" : 915
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 210,
        "y" : 919
      },
      "b" : {
        "x" : 217,
        "y" : 915
      },
      "c" : {
        "x" : 210,
        "y" : 911
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 210,
        "y" : 911
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 100,
        "y" : 912
      },
      "b" : {
        "x" : 112,
        "y" : 924
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 106,
        "y" : 918
      }
    },
    "inputs" : [ {
      "id" : 138084
    } ],
    "outputs" : [ {
      "id" : 138092
    } ],
    "catalysts" : [ {
      "id" : 138093,
      "points" : [ {
        "x" : 91,
        "y" : 957
      } ]
    } ]
  }, {
    "id" : 138155,
    "reactomeId" : 10539483,
    "displayName" : "MMP13 cleaves OPTC",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1399,
      "y" : 1063
    },
    "minX" : 1289,
    "maxX" : 1449,
    "minY" : 956,
    "maxY" : 1069,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1289,
        "y" : 956
      },
      "to" : {
        "x" : 1399,
        "y" : 1063
      }
    }, {
      "from" : {
        "x" : 1399,
        "y" : 1063
      },
      "to" : {
        "x" : 1449,
        "y" : 1063
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1393,
        "y" : 1057
      },
      "b" : {
        "x" : 1405,
        "y" : 1069
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1399,
        "y" : 1063
      }
    },
    "inputs" : [ {
      "id" : 138150
    } ],
    "outputs" : [ {
      "id" : 138156,
      "points" : [ {
        "x" : 1507,
        "y" : 1082
      } ]
    }, {
      "id" : 138151,
      "points" : [ {
        "x" : 1660,
        "y" : 951
      } ]
    } ],
    "catalysts" : [ {
      "id" : 138157,
      "points" : [ {
        "x" : 1341,
        "y" : 1065
      } ]
    } ]
  }, {
    "id" : 138089,
    "reactomeId" : 10508576,
    "displayName" : "Fibronectin degradation by CTSG",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 165,
      "y" : 827
    },
    "minX" : 119,
    "maxX" : 235,
    "minY" : 821,
    "maxY" : 833,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 119,
        "y" : 822
      },
      "to" : {
        "x" : 165,
        "y" : 827
      }
    }, {
      "from" : {
        "x" : 165,
        "y" : 827
      },
      "to" : {
        "x" : 235,
        "y" : 824
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 228,
        "y" : 828
      },
      "b" : {
        "x" : 235,
        "y" : 824
      },
      "c" : {
        "x" : 228,
        "y" : 820
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 228,
        "y" : 820
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 159,
        "y" : 821
      },
      "b" : {
        "x" : 171,
        "y" : 833
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 165,
        "y" : 827
      }
    },
    "inputs" : [ {
      "id" : 138084
    } ],
    "outputs" : [ {
      "id" : 138085
    } ],
    "catalysts" : [ {
      "id" : 138090,
      "points" : [ {
        "x" : 117,
        "y" : 763
      } ]
    } ]
  }, {
    "id" : 138094,
    "reactomeId" : 10508722,
    "displayName" : "Laminin-322 degradation by MMP14",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 940,
      "y" : 110
    },
    "minX" : 916,
    "maxX" : 972,
    "minY" : 104,
    "maxY" : 116,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 916,
        "y" : 105
      },
      "to" : {
        "x" : 940,
        "y" : 110
      }
    }, {
      "from" : {
        "x" : 940,
        "y" : 110
      },
      "to" : {
        "x" : 972,
        "y" : 106
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 966,
        "y" : 111
      },
      "b" : {
        "x" : 972,
        "y" : 106
      },
      "c" : {
        "x" : 965,
        "y" : 103
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 965,
        "y" : 103
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 934,
        "y" : 104
      },
      "b" : {
        "x" : 946,
        "y" : 116
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 940,
        "y" : 110
      }
    },
    "inputs" : [ {
      "id" : 138095
    } ],
    "outputs" : [ {
      "id" : 138096
    } ],
    "catalysts" : [ {
      "id" : 138078,
      "points" : [ {
        "x" : 466,
        "y" : 373
      } ]
    } ]
  }, {
    "id" : 138158,
    "reactomeId" : 10539326,
    "displayName" : "MMP7 cleaves OPTC",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1373,
      "y" : 947
    },
    "minX" : 1306,
    "maxX" : 1409,
    "minY" : 941,
    "maxY" : 953,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1306,
        "y" : 943
      },
      "to" : {
        "x" : 1373,
        "y" : 947
      }
    }, {
      "from" : {
        "x" : 1373,
        "y" : 947
      },
      "to" : {
        "x" : 1409,
        "y" : 946
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1367,
        "y" : 941
      },
      "b" : {
        "x" : 1379,
        "y" : 953
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1373,
        "y" : 947
      }
    },
    "inputs" : [ {
      "id" : 138150
    } ],
    "outputs" : [ {
      "id" : 138153,
      "points" : [ {
        "x" : 1455,
        "y" : 931
      } ]
    }, {
      "id" : 138159,
      "points" : [ {
        "x" : 1445,
        "y" : 953
      } ]
    }, {
      "id" : 138151,
      "points" : [ {
        "x" : 1626,
        "y" : 938
      } ]
    }, {
      "id" : 138160,
      "points" : [ {
        "x" : 1427,
        "y" : 984
      } ]
    } ],
    "catalysts" : [ {
      "id" : 138161,
      "points" : [ {
        "x" : 1376,
        "y" : 922
      } ]
    } ]
  }, {
    "id" : 138162,
    "reactomeId" : 10539626,
    "displayName" : "MMP2, MMP9 cleave SCUBE3",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1434,
      "y" : 729
    },
    "minX" : 1393,
    "maxX" : 1470,
    "minY" : 704,
    "maxY" : 735,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1393,
        "y" : 704
      },
      "to" : {
        "x" : 1434,
        "y" : 729
      }
    }, {
      "from" : {
        "x" : 1434,
        "y" : 729
      },
      "to" : {
        "x" : 1470,
        "y" : 729
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1428,
        "y" : 723
      },
      "b" : {
        "x" : 1440,
        "y" : 735
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1434,
        "y" : 729
      }
    },
    "inputs" : [ {
      "id" : 138163
    } ],
    "outputs" : [ {
      "id" : 138164,
      "points" : [ {
        "x" : 1472,
        "y" : 705
      } ]
    }, {
      "id" : 138165,
      "points" : [ {
        "x" : 1556,
        "y" : 706
      } ]
    } ],
    "catalysts" : [ {
      "id" : 138166,
      "points" : [ {
        "x" : 1434,
        "y" : 761
      } ]
    } ]
  }, {
    "id" : 138097,
    "reactomeId" : 10508748,
    "displayName" : "E-cadherin degradation by MMP9, KLK7",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 448,
      "y" : 579
    },
    "minX" : 433,
    "maxX" : 533,
    "minY" : 459,
    "maxY" : 620,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 533,
        "y" : 459
      },
      "to" : {
        "x" : 448,
        "y" : 579
      }
    }, {
      "from" : {
        "x" : 448,
        "y" : 579
      },
      "to" : {
        "x" : 433,
        "y" : 620
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 442,
        "y" : 573
      },
      "b" : {
        "x" : 454,
        "y" : 585
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 448,
        "y" : 579
      }
    },
    "inputs" : [ {
      "id" : 138098
    } ],
    "outputs" : [ {
      "id" : 138099,
      "points" : [ {
        "x" : 486,
        "y" : 663
      } ]
    }, {
      "id" : 138100,
      "points" : [ {
        "x" : 395,
        "y" : 658
      } ]
    } ],
    "catalysts" : [ {
      "id" : 138101,
      "points" : [ {
        "x" : 311,
        "y" : 565
      } ]
    } ]
  }, {
    "id" : 138102,
    "reactomeId" : 10508729,
    "displayName" : "NID1 degradation by MMP19",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1274,
      "y" : 136
    },
    "minX" : 1185,
    "maxX" : 1308,
    "minY" : 130,
    "maxY" : 142,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1185,
        "y" : 137
      },
      "to" : {
        "x" : 1274,
        "y" : 136
      }
    }, {
      "from" : {
        "x" : 1274,
        "y" : 136
      },
      "to" : {
        "x" : 1308,
        "y" : 136
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1268,
        "y" : 130
      },
      "b" : {
        "x" : 1280,
        "y" : 142
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1274,
        "y" : 136
      }
    },
    "inputs" : [ {
      "id" : 138103
    } ],
    "outputs" : [ {
      "id" : 138104,
      "points" : [ {
        "x" : 1387,
        "y" : 176
      } ]
    }, {
      "id" : 138105,
      "points" : [ {
        "x" : 1369,
        "y" : 124
      } ]
    } ],
    "catalysts" : [ {
      "id" : 138106,
      "points" : [ {
        "x" : 1209,
        "y" : 76
      } ]
    } ]
  }, {
    "id" : 138167,
    "reactomeId" : 10539640,
    "displayName" : "SCUBE1, SCUBE3 oligomerize",
    "schemaClass" : "Polymerisation",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1182,
      "y" : 693
    },
    "minX" : 1163,
    "maxX" : 1202,
    "minY" : 687,
    "maxY" : 699,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 1163,
        "y" : 693
      },
      "to" : {
        "x" : 1182,
        "y" : 693
      }
    }, {
      "from" : {
        "x" : 1182,
        "y" : 693
      },
      "to" : {
        "x" : 1202,
        "y" : 693
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1195,
        "y" : 697
      },
      "b" : {
        "x" : 1202,
        "y" : 693
      },
      "c" : {
        "x" : 1195,
        "y" : 689
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1195,
        "y" : 689
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1182,
        "y" : 693
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1182,
        "y" : 693
      }
    },
    "inputs" : [ {
      "id" : 138168
    } ],
    "outputs" : [ {
      "id" : 138169
    } ]
  }, {
    "id" : 138107,
    "reactomeId" : 10508636,
    "displayName" : "Brevican degradation by ADAMTS4, ADAMTS5",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1581,
      "y" : 163
    },
    "minX" : 1558,
    "maxX" : 1621,
    "minY" : 157,
    "maxY" : 172,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1558,
        "y" : 172
      },
      "to" : {
        "x" : 1581,
        "y" : 163
      }
    }, {
      "from" : {
        "x" : 1581,
        "y" : 163
      },
      "to" : {
        "x" : 1621,
        "y" : 162
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1575,
        "y" : 157
      },
      "b" : {
        "x" : 1587,
        "y" : 169
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1581,
        "y" : 163
      }
    },
    "inputs" : [ {
      "id" : 138108
    } ],
    "outputs" : [ {
      "id" : 138109,
      "points" : [ {
        "x" : 1674,
        "y" : 168
      } ]
    }, {
      "id" : 138110,
      "points" : [ {
        "x" : 1674,
        "y" : 154
      } ]
    } ],
    "catalysts" : [ {
      "id" : 138111,
      "points" : [ {
        "x" : 1578,
        "y" : 131
      } ]
    } ]
  } ],
  "compartments" : [ {
    "id" : 138172,
    "reactomeId" : 70101,
    "displayName" : "cytosol",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 987,
      "y" : 565
    },
    "minX" : 354,
    "maxX" : 1620,
    "minY" : 432,
    "maxY" : 699,
    "prop" : {
      "x" : 354,
      "y" : 432,
      "width" : 1266,
      "height" : 267
    },
    "textPosition" : {
      "x" : 1037,
      "y" : 563
    },
    "insets" : {
      "x" : 364,
      "y" : 442,
      "width" : 1246,
      "height" : 247
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 138098, 138099, 138135, 138100, 138097, 138136, 138137, 138138, 138139, 138140, 138142, 138141, 138128, 138129, 138163, 138164, 138165, 138168, 138169, 138167, 138177 ]
  } ],
  "notes" : [ ],
  "links" : [ {
    "id" : 138178,
    "renderableClass" : "EntitySetAndEntitySetLink",
    "position" : {
      "x" : 1506,
      "y" : 531
    },
    "minX" : 1438,
    "maxX" : 1574,
    "minY" : 302,
    "maxY" : 761,
    "segments" : [ {
      "from" : {
        "x" : 1438,
        "y" : 761
      },
      "to" : {
        "x" : 1574,
        "y" : 302
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1500,
        "y" : 525
      },
      "b" : {
        "x" : 1512,
        "y" : 537
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1506,
        "y" : 531
      }
    },
    "inputs" : [ {
      "id" : 138166
    } ],
    "outputs" : [ {
      "id" : 138115
    } ]
  }, {
    "id" : 138179,
    "renderableClass" : "EntitySetAndEntitySetLink",
    "position" : {
      "x" : 1054,
      "y" : 408
    },
    "minX" : 686,
    "maxX" : 1423,
    "minY" : 56,
    "maxY" : 761,
    "segments" : [ {
      "from" : {
        "x" : 1423,
        "y" : 761
      },
      "to" : {
        "x" : 686,
        "y" : 56
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1048,
        "y" : 402
      },
      "b" : {
        "x" : 1060,
        "y" : 414
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1054,
        "y" : 408
      }
    },
    "inputs" : [ {
      "id" : 138166
    } ],
    "outputs" : [ {
      "id" : 138076
    } ]
  }, {
    "id" : 138177,
    "renderableClass" : "EntitySetAndMemberLink",
    "position" : {
      "x" : 1393,
      "y" : 798
    },
    "minX" : 1379,
    "maxX" : 1408,
    "minY" : 792,
    "maxY" : 804,
    "segments" : [ {
      "from" : {
        "x" : 1379,
        "y" : 801
      },
      "to" : {
        "x" : 1408,
        "y" : 795
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1387,
        "y" : 792
      },
      "b" : {
        "x" : 1399,
        "y" : 804
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1393,
        "y" : 798
      }
    },
    "inputs" : [ {
      "id" : 138154
    } ],
    "outputs" : [ {
      "id" : 138166
    } ]
  }, {
    "id" : 138182,
    "renderableClass" : "EntitySetAndEntitySetLink",
    "position" : {
      "x" : 750,
      "y" : 907
    },
    "minX" : 114,
    "maxX" : 1386,
    "minY" : 786,
    "maxY" : 1028,
    "segments" : [ {
      "from" : {
        "x" : 1386,
        "y" : 786
      },
      "to" : {
        "x" : 114,
        "y" : 1028
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 744,
        "y" : 901
      },
      "b" : {
        "x" : 756,
        "y" : 913
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 750,
        "y" : 907
      }
    },
    "inputs" : [ {
      "id" : 138166
    } ],
    "outputs" : [ {
      "id" : 138124
    } ]
  }, {
    "id" : 138183,
    "renderableClass" : "EntitySetAndEntitySetLink",
    "position" : {
      "x" : 927,
      "y" : 410
    },
    "minX" : 435,
    "maxX" : 1419,
    "minY" : 59,
    "maxY" : 761,
    "segments" : [ {
      "from" : {
        "x" : 1419,
        "y" : 761
      },
      "to" : {
        "x" : 435,
        "y" : 59
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 921,
        "y" : 404
      },
      "b" : {
        "x" : 933,
        "y" : 416
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 927,
        "y" : 410
      }
    },
    "inputs" : [ {
      "id" : 138166
    } ],
    "outputs" : [ {
      "id" : 138120
    } ]
  }, {
    "id" : 138180,
    "renderableClass" : "EntitySetAndEntitySetLink",
    "position" : {
      "x" : 1309,
      "y" : 588
    },
    "minX" : 1192,
    "maxX" : 1427,
    "minY" : 415,
    "maxY" : 761,
    "segments" : [ {
      "from" : {
        "x" : 1427,
        "y" : 761
      },
      "to" : {
        "x" : 1192,
        "y" : 415
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1303,
        "y" : 582
      },
      "b" : {
        "x" : 1315,
        "y" : 594
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1309,
        "y" : 588
      }
    },
    "inputs" : [ {
      "id" : 138166
    } ],
    "outputs" : [ {
      "id" : 138127
    } ]
  }, {
    "id" : 138186,
    "renderableClass" : "EntitySetAndEntitySetLink",
    "position" : {
      "x" : 787,
      "y" : 489
    },
    "minX" : 165,
    "maxX" : 1410,
    "minY" : 217,
    "maxY" : 761,
    "segments" : [ {
      "from" : {
        "x" : 1410,
        "y" : 761
      },
      "to" : {
        "x" : 165,
        "y" : 217
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 781,
        "y" : 483
      },
      "b" : {
        "x" : 793,
        "y" : 495
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 787,
        "y" : 489
      }
    },
    "inputs" : [ {
      "id" : 138166
    } ],
    "outputs" : [ {
      "id" : 138082
    } ]
  }, {
    "id" : 138187,
    "renderableClass" : "EntitySetAndEntitySetLink",
    "position" : {
      "x" : 848,
      "y" : 668
    },
    "minX" : 311,
    "maxX" : 1386,
    "minY" : 568,
    "maxY" : 769,
    "segments" : [ {
      "from" : {
        "x" : 1386,
        "y" : 769
      },
      "to" : {
        "x" : 311,
        "y" : 568
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 842,
        "y" : 662
      },
      "b" : {
        "x" : 854,
        "y" : 674
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 848,
        "y" : 668
      }
    },
    "inputs" : [ {
      "id" : 138166
    } ],
    "outputs" : [ {
      "id" : 138101
    } ]
  } ],
  "shadows" : [ ],
  "minX" : 0,
  "maxX" : 1789,
  "minY" : 0,
  "maxY" : 1151,
  "disease" : false
}