{ "dbId" : 11078497, "stableId" : "R-SPO-9955298", "displayName" : "SLC-mediated transport of organic anions", "nodes" : [ { "id" : 25109, "reactomeId" : 29654, "displayName" : "CIT", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2013, "y" : 634 }, "minX" : 1998, "maxX" : 2105, "minY" : 618, "maxY" : 650, "prop" : { "x" : 1998, "y" : 619, "width" : 31, "height" : 31 }, "textPosition" : { "x" : 2000, "y" : 624 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2024, "y" : 624 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2024, "y" : 624 } } }, "connectors" : [ { "edgeId" : 25108, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2032, "y" : 634 }, "to" : { "x" : 2105, "y" : 636 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 25110, "reactomeId" : 198498, "displayName" : "MAL", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2206, "y" : 680 }, "minX" : 2105, "maxX" : 2229, "minY" : 636, "maxY" : 696, "prop" : { "x" : 2185, "y" : 665, "width" : 43, "height" : 31 }, "textPosition" : { "x" : 2190, "y" : 670 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2223, "y" : 670 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2223, "y" : 670 } } }, "connectors" : [ { "edgeId" : 25108, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2182, "y" : 670 }, "to" : { "x" : 2105, "y" : 636 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 25111, "reactomeId" : 76190, "displayName" : "CIT", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2213, "y" : 601 }, "minX" : 2109, "maxX" : 2231, "minY" : 585, "maxY" : 635, "prop" : { "x" : 2196, "y" : 586, "width" : 34, "height" : 31 }, "textPosition" : { "x" : 2200, "y" : 591 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2225, "y" : 591 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2225, "y" : 591 } } }, "connectors" : [ { "edgeId" : 25108, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 2193, "y" : 606 }, "to" : { "x" : 2109, "y" : 635 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2188, "y" : 612 }, "b" : { "x" : 2193, "y" : 606 }, "c" : { "x" : 2185, "y" : 604 }, "type" : "ARROW", "centre" : { "x" : 2185, "y" : 604 } } } ] }, { "id" : 25112, "reactomeId" : 113544, "displayName" : "MAL", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1825, "y" : 555 }, "minX" : 1804, "maxX" : 2109, "minY" : 539, "maxY" : 635, "prop" : { "x" : 1804, "y" : 540, "width" : 43, "height" : 31 }, "textPosition" : { "x" : 1809, "y" : 545 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1842, "y" : 545 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1842, "y" : 545 } } }, "connectors" : [ { "edgeId" : 25108, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1850, "y" : 561 }, "to" : { "x" : 2109, "y" : 635 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1858, "y" : 559 }, "b" : { "x" : 1850, "y" : 561 }, "c" : { "x" : 1856, "y" : 567 }, "type" : "ARROW", "centre" : { "x" : 1856, "y" : 567 } } } ] }, { "id" : 25113, "reactomeId" : 11054939, "displayName" : "SLC25A1", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 2005, "y" : 684 }, "minX" : 1894, "maxX" : 2100, "minY" : 636, "maxY" : 696, "prop" : { "x" : 1975, "y" : 673, "width" : 60, "height" : 23 }, "textPosition" : { "x" : 1978, "y" : 667 }, "connectors" : [ { "edgeId" : 25108, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 2029, "y" : 667 }, "to" : { "x" : 2092, "y" : 641 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 2096, "y" : 640 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2096, "y" : 640 } } }, { "edgeId" : 25114, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1969, "y" : 683 }, "to" : { "x" : 1902, "y" : 682 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1898, "y" : 682 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1898, "y" : 682 } } } ] }, { "id" : 25115, "reactomeId" : 372364, "displayName" : "PEP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1814, "y" : 618 }, "minX" : 1795, "maxX" : 1886, "minY" : 602, "maxY" : 686, "prop" : { "x" : 1795, "y" : 603, "width" : 39, "height" : 31 }, "textPosition" : { "x" : 1798, "y" : 608 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1829, "y" : 608 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1829, "y" : 608 } } }, "connectors" : [ { "edgeId" : 25114, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1830, "y" : 637 }, "to" : { "x" : 1886, "y" : 686 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 25116, "reactomeId" : 1454930, "displayName" : "organic anion", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1930, "y" : 742 }, "minX" : 1881, "maxX" : 1980, "minY" : 686, "maxY" : 758, "prop" : { "x" : 1881, "y" : 727, "width" : 98, "height" : 31 }, "textPosition" : { "x" : 1883, "y" : 732 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1974, "y" : 732 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1974, "y" : 732 } } }, "connectors" : [ { "edgeId" : 25114, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1917, "y" : 724 }, "to" : { "x" : 1886, "y" : 686 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 25117, "reactomeId" : 9815686, "displayName" : "organic anion", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1938, "y" : 628 }, "minX" : 1884, "maxX" : 1988, "minY" : 612, "maxY" : 681, "prop" : { "x" : 1889, "y" : 613, "width" : 98, "height" : 31 }, "textPosition" : { "x" : 1891, "y" : 618 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1982, "y" : 618 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1982, "y" : 618 } } }, "connectors" : [ { "edgeId" : 25114, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1922, "y" : 647 }, "to" : { "x" : 1884, "y" : 681 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1920, "y" : 655 }, "b" : { "x" : 1922, "y" : 647 }, "c" : { "x" : 1914, "y" : 649 }, "type" : "ARROW", "centre" : { "x" : 1914, "y" : 649 } } } ] }, { "id" : 25118, "reactomeId" : 29492, "displayName" : "PEP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1824, "y" : 754 }, "minX" : 1805, "maxX" : 1884, "minY" : 681, "maxY" : 770, "prop" : { "x" : 1805, "y" : 739, "width" : 39, "height" : 31 }, "textPosition" : { "x" : 1808, "y" : 744 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1839, "y" : 744 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1839, "y" : 744 } } }, "connectors" : [ { "edgeId" : 25114, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1836, "y" : 736 }, "to" : { "x" : 1884, "y" : 681 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1838, "y" : 728 }, "b" : { "x" : 1836, "y" : 736 }, "c" : { "x" : 1844, "y" : 733 }, "type" : "ARROW", "centre" : { "x" : 1844, "y" : 733 } } } ] } ], "edges" : [ { "id" : 25108, "reactomeId" : 11054942, "displayName" : "SLC25A1 exchanges CIT and MAL", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2107, "y" : 635 }, "minX" : 2103, "maxX" : 2115, "minY" : 629, "maxY" : 641, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 2105, "y" : 636 }, "to" : { "x" : 2107, "y" : 635 } }, { "from" : { "x" : 2107, "y" : 635 }, "to" : { "x" : 2109, "y" : 635 } } ], "reactionShape" : { "a" : { "x" : 2101, "y" : 629 }, "b" : { "x" : 2113, "y" : 641 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2107, "y" : 635 } }, "inputs" : [ { "id" : 25109, "points" : [ { "x" : 2032, "y" : 634 } ] }, { "id" : 25110, "points" : [ { "x" : 2182, "y" : 670 } ] } ], "outputs" : [ { "id" : 25111, "points" : [ { "x" : 2193, "y" : 606 } ] }, { "id" : 25112, "points" : [ { "x" : 1850, "y" : 561 } ] } ], "catalysts" : [ { "id" : 25113, "points" : [ { "x" : 2029, "y" : 667 } ] } ] }, { "id" : 25114, "reactomeId" : 11059510, "displayName" : "SLC25A1 may exchange mitochondrial PEP for cytosolic anion", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1886, "y" : 682 }, "minX" : 1880, "maxX" : 1892, "minY" : 676, "maxY" : 688, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1886, "y" : 686 }, "to" : { "x" : 1886, "y" : 682 } }, { "from" : { "x" : 1886, "y" : 682 }, "to" : { "x" : 1884, "y" : 681 } } ], "reactionShape" : { "a" : { "x" : 1880, "y" : 676 }, "b" : { "x" : 1892, "y" : 688 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1886, "y" : 682 } }, "inputs" : [ { "id" : 25115, "points" : [ { "x" : 1830, "y" : 637 } ] }, { "id" : 25116, "points" : [ { "x" : 1917, "y" : 724 } ] } ], "outputs" : [ { "id" : 25117, "points" : [ { "x" : 1922, "y" : 647 } ] }, { "id" : 25118, "points" : [ { "x" : 1836, "y" : 736 } ] } ], "catalysts" : [ { "id" : 25113, "points" : [ { "x" : 1969, "y" : 683 } ] } ] } ], "compartments" : [ { "id" : 25152, "reactomeId" : 161320, "displayName" : "lysosomal lumen", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 435, "y" : 319 }, "minX" : 321, "maxX" : 550, "minY" : 225, "maxY" : 413, "prop" : { "x" : 321, "y" : 225, "width" : 229, "height" : 188 }, "textPosition" : { "x" : 385, "y" : 362 }, "insets" : { "x" : 331, "y" : 235, "width" : 209, "height" : 168 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 } }, { "id" : 25159, "reactomeId" : 5460, "displayName" : "mitochondrial matrix", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 1899, "y" : 556 }, "minX" : 1683, "maxX" : 2115, "minY" : 427, "maxY" : 685, "prop" : { "x" : 1683, "y" : 427, "width" : 432, "height" : 258 }, "textPosition" : { "x" : 1956, "y" : 470 }, "insets" : { "x" : 1693, "y" : 437, "width" : 412, "height" : 238 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 25112, 25113, 25108, 25109, 25117, 25115, 25114 ] }, { "id" : 25119, "reactomeId" : 70101, "displayName" : "cytosol", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 1159, "y" : 483 }, "minX" : 0, "maxX" : 2318, "minY" : 0, "maxY" : 967, "prop" : { "x" : 0, "y" : 0, "width" : 2318, "height" : 967 }, "textPosition" : { "x" : 694, "y" : 196 }, "insets" : { "x" : 10, "y" : 10, "width" : 2298, "height" : 947 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 25166, 25167, 25152, 25168, 25111, 25159, 25116, 25118, 25110 ] } ], "notes" : [ ], "links" : [ ], "shadows" : [ { "id" : 25160, "reactomeId" : 11078495, "displayName" : "Organic anion transport by SLC5/17/25 transporters", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 2012, "y" : 655 }, "minX" : 1785, "maxX" : 2240, "minY" : 530, "maxY" : 780, "prop" : { "x" : 1785, "y" : 530, "width" : 455, "height" : 250 }, "points" : [ { "x" : 1785, "y" : 530 }, { "x" : 2240, "y" : 530 }, { "x" : 2240, "y" : 780 }, { "x" : 1785, "y" : 780 } ], "colour" : "#4684ee" } ], "minX" : 0, "maxX" : 2318, "minY" : 0, "maxY" : 967, "disease" : false }