{
  "dbId" : 11078621,
  "stableId" : "R-SPO-432040",
  "displayName" : "Vasopressin regulates renal water homeostasis via Aquaporins",
  "nodes" : [ {
    "id" : 19410,
    "reactomeId" : 29356,
    "displayName" : "H2O",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 364,
      "y" : 1694
    },
    "minX" : 318,
    "maxX" : 412,
    "minY" : 1678,
    "maxY" : 1710,
    "prop" : {
      "x" : 318,
      "y" : 1679,
      "width" : 93,
      "height" : 31
    },
    "textPosition" : {
      "x" : 347,
      "y" : 1684
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 406,
          "y" : 1684
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 406,
          "y" : 1684
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 19409,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 19411,
    "reactomeId" : 109276,
    "displayName" : "H2O",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 773,
      "y" : 1611
    },
    "minX" : 739,
    "maxX" : 808,
    "minY" : 1590,
    "maxY" : 1631,
    "prop" : {
      "x" : 739,
      "y" : 1591,
      "width" : 68,
      "height" : 40
    },
    "textPosition" : {
      "x" : 756,
      "y" : 1600
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 802,
          "y" : 1596
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 802,
          "y" : 1596
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 19409,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 19412,
    "reactomeId" : 11060679,
    "displayName" : "AQP3 tetramer",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 642,
      "y" : 1537
    },
    "minX" : 588,
    "maxX" : 702,
    "minY" : 1518,
    "maxY" : 1605,
    "prop" : {
      "x" : 588,
      "y" : 1524,
      "width" : 108,
      "height" : 27
    },
    "textPosition" : {
      "x" : 592,
      "y" : 1530
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 696,
          "y" : 1524
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 696,
          "y" : 1524
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 19409,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 638,
          "y" : 1554
        },
        "to" : {
          "x" : 626,
          "y" : 1598
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 625,
          "y" : 1601
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 625,
          "y" : 1601
        }
      }
    } ]
  }, {
    "id" : 19414,
    "reactomeId" : 11055794,
    "displayName" : "PKA tetramer",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 422,
      "y" : 1179
    },
    "minX" : 372,
    "maxX" : 503,
    "minY" : 1160,
    "maxY" : 1195,
    "prop" : {
      "x" : 372,
      "y" : 1166,
      "width" : 101,
      "height" : 27
    },
    "textPosition" : {
      "x" : 377,
      "y" : 1172
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 473,
          "y" : 1166
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 473,
          "y" : 1166
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 19413,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 476,
          "y" : 1188
        },
        "to" : {
          "x" : 503,
          "y" : 1195
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 19415,
    "reactomeId" : 30389,
    "displayName" : "cAMP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 527,
      "y" : 1132
    },
    "minX" : 476,
    "maxX" : 579,
    "minY" : 1113,
    "maxY" : 1195,
    "prop" : {
      "x" : 476,
      "y" : 1114,
      "width" : 102,
      "height" : 36
    },
    "textPosition" : {
      "x" : 506,
      "y" : 1121
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 573,
          "y" : 1119
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 573,
          "y" : 1119
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 19413,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 520,
          "y" : 1153
        },
        "to" : {
          "x" : 503,
          "y" : 1195
        }
      } ],
      "stoichiometry" : {
        "value" : 4,
        "shape" : {
          "a" : {
            "x" : 505,
            "y" : 1168
          },
          "b" : {
            "x" : 517,
            "y" : 1180
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 511,
            "y" : 1174
          }
        }
      }
    } ]
  }, {
    "id" : 19416,
    "reactomeId" : 11055796,
    "displayName" : "PKA tetramer:4xcAMP",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 501,
      "y" : 1273
    },
    "minX" : 403,
    "maxX" : 555,
    "minY" : 1249,
    "maxY" : 1306,
    "prop" : {
      "x" : 454,
      "y" : 1255,
      "width" : 95,
      "height" : 36
    },
    "textPosition" : {
      "x" : 454,
      "y" : 1256
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 549,
          "y" : 1255
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 549,
          "y" : 1255
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 19413,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 19417,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 19417,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 451,
          "y" : 1289
        },
        "to" : {
          "x" : 408,
          "y" : 1306
        }
      }, {
        "from" : {
          "x" : 408,
          "y" : 1306
        },
        "to" : {
          "x" : 407,
          "y" : 1288
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 407,
          "y" : 1284
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 407,
          "y" : 1284
        }
      }
    } ]
  }, {
    "id" : 19418,
    "reactomeId" : 11055792,
    "displayName" : "PRKACA",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 299,
      "y" : 1318
    },
    "minX" : 214,
    "maxX" : 391,
    "minY" : 1270,
    "maxY" : 1329,
    "prop" : {
      "x" : 214,
      "y" : 1307,
      "width" : 171,
      "height" : 22
    },
    "textPosition" : {
      "x" : 272,
      "y" : 1307
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 385,
          "y" : 1307
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 385,
          "y" : 1307
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 19417,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 304,
          "y" : 1301
        },
        "to" : {
          "x" : 321,
          "y" : 1270
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 306,
            "y" : 1279
          },
          "b" : {
            "x" : 318,
            "y" : 1291
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 312,
            "y" : 1285
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 304,
          "y" : 1293
        },
        "b" : {
          "x" : 304,
          "y" : 1301
        },
        "c" : {
          "x" : 311,
          "y" : 1297
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 311,
          "y" : 1297
        }
      }
    } ]
  }, {
    "id" : 19419,
    "reactomeId" : 11055798,
    "displayName" : "cAMP:PKA regulatory subunit",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 295,
      "y" : 1233
    },
    "minX" : 200,
    "maxX" : 396,
    "minY" : 1213,
    "maxY" : 1270,
    "prop" : {
      "x" : 200,
      "y" : 1219,
      "width" : 190,
      "height" : 28
    },
    "textPosition" : {
      "x" : 201,
      "y" : 1226
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 390,
          "y" : 1219
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 390,
          "y" : 1219
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 19417,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 304,
          "y" : 1250
        },
        "to" : {
          "x" : 321,
          "y" : 1270
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 312,
          "y" : 1253
        },
        "b" : {
          "x" : 304,
          "y" : 1250
        },
        "c" : {
          "x" : 305,
          "y" : 1258
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 305,
          "y" : 1258
        }
      }
    } ]
  } ],
  "edges" : [ {
    "id" : 19409,
    "reactomeId" : 11060682,
    "displayName" : "Aquaporin-3 passively transports water out of cell",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 622,
      "y" : 1613
    },
    "minX" : 414,
    "maxX" : 736,
    "minY" : 1607,
    "maxY" : 1679,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 414,
        "y" : 1679
      },
      "to" : {
        "x" : 622,
        "y" : 1613
      }
    }, {
      "from" : {
        "x" : 622,
        "y" : 1613
      },
      "to" : {
        "x" : 736,
        "y" : 1611
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 729,
        "y" : 1615
      },
      "b" : {
        "x" : 736,
        "y" : 1611
      },
      "c" : {
        "x" : 729,
        "y" : 1607
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 729,
        "y" : 1607
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 616,
        "y" : 1607
      },
      "b" : {
        "x" : 628,
        "y" : 1619
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 622,
        "y" : 1613
      }
    },
    "inputs" : [ {
      "id" : 19410
    } ],
    "outputs" : [ {
      "id" : 19411
    } ],
    "catalysts" : [ {
      "id" : 19412,
      "points" : [ {
        "x" : 638,
        "y" : 1554
      } ]
    } ]
  }, {
    "id" : 19413,
    "reactomeId" : 11074232,
    "displayName" : "cAMP binds PKA tetramer",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 503,
      "y" : 1228
    },
    "minX" : 497,
    "maxX" : 509,
    "minY" : 1195,
    "maxY" : 1252,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 503,
        "y" : 1195
      },
      "to" : {
        "x" : 503,
        "y" : 1228
      }
    }, {
      "from" : {
        "x" : 503,
        "y" : 1228
      },
      "to" : {
        "x" : 501,
        "y" : 1252
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 498,
        "y" : 1245
      },
      "b" : {
        "x" : 501,
        "y" : 1252
      },
      "c" : {
        "x" : 506,
        "y" : 1245
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 506,
        "y" : 1245
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 503,
        "y" : 1228
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 503,
        "y" : 1228
      }
    },
    "inputs" : [ {
      "id" : 19414,
      "points" : [ {
        "x" : 476,
        "y" : 1188
      } ]
    }, {
      "id" : 19415,
      "points" : [ {
        "x" : 520,
        "y" : 1153
      } ],
      "stoichiometry" : 4
    } ],
    "outputs" : [ {
      "id" : 19416
    } ]
  }, {
    "id" : 19417,
    "reactomeId" : 11055801,
    "displayName" : "cAMP induces dissociation of inactive PKA tetramers",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 407,
      "y" : 1272
    },
    "minX" : 321,
    "maxX" : 451,
    "minY" : 1266,
    "maxY" : 1278,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 451,
        "y" : 1272
      },
      "to" : {
        "x" : 407,
        "y" : 1272
      }
    }, {
      "from" : {
        "x" : 407,
        "y" : 1272
      },
      "to" : {
        "x" : 321,
        "y" : 1270
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 401,
        "y" : 1266
      },
      "b" : {
        "x" : 413,
        "y" : 1278
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 407,
        "y" : 1272
      }
    },
    "inputs" : [ {
      "id" : 19416
    } ],
    "outputs" : [ {
      "id" : 19418,
      "points" : [ {
        "x" : 304,
        "y" : 1301
      } ],
      "stoichiometry" : 2
    }, {
      "id" : 19419,
      "points" : [ {
        "x" : 304,
        "y" : 1250
      } ]
    } ],
    "catalysts" : [ {
      "id" : 19416,
      "points" : [ {
        "x" : 451,
        "y" : 1289
      }, {
        "x" : 408,
        "y" : 1306
      } ]
    } ]
  } ],
  "compartments" : [ {
    "id" : 19429,
    "reactomeId" : 437050,
    "displayName" : "cytoplasmic vesicle lumen",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 417,
      "y" : 1437
    },
    "minX" : 291,
    "maxX" : 543,
    "minY" : 1384,
    "maxY" : 1490,
    "prop" : {
      "x" : 291,
      "y" : 1384,
      "width" : 252,
      "height" : 106
    },
    "textPosition" : {
      "x" : 313,
      "y" : 1409
    },
    "insets" : {
      "x" : 301,
      "y" : 1394,
      "width" : 232,
      "height" : 86
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    }
  }, {
    "id" : 19420,
    "reactomeId" : 70101,
    "displayName" : "cytosol",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 436,
      "y" : 123
    },
    "minX" : 172,
    "maxX" : 700,
    "minY" : 0,
    "maxY" : 246,
    "prop" : {
      "x" : 172,
      "y" : 0,
      "width" : 528,
      "height" : 246
    },
    "textPosition" : {
      "x" : 189,
      "y" : 193
    },
    "insets" : {
      "x" : 182,
      "y" : 10,
      "width" : 508,
      "height" : 226
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 19434 ]
  }, {
    "id" : 19421,
    "reactomeId" : 70101,
    "displayName" : "cytosol",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 436,
      "y" : 1031
    },
    "minX" : 175,
    "maxX" : 697,
    "minY" : 256,
    "maxY" : 1806,
    "prop" : {
      "x" : 175,
      "y" : 256,
      "width" : 522,
      "height" : 1550
    },
    "textPosition" : {
      "x" : 194,
      "y" : 877
    },
    "insets" : {
      "x" : 185,
      "y" : 266,
      "width" : 502,
      "height" : 1530
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 19415, 19419, 19418, 19414, 19429, 19412, 19409, 19410, 19435, 19416, 19413, 19417 ]
  } ],
  "notes" : [ {
    "id" : 19432,
    "displayName" : "Filtrate",
    "renderableClass" : "Note",
    "position" : {
      "x" : 44,
      "y" : 31
    },
    "minX" : 0,
    "maxX" : 89,
    "minY" : 20,
    "maxY" : 43,
    "prop" : {
      "x" : 0,
      "y" : 20,
      "width" : 89,
      "height" : 23
    },
    "textPosition" : {
      "x" : 18,
      "y" : 21
    }
  }, {
    "id" : 19433,
    "displayName" : "Bloodstream",
    "renderableClass" : "Note",
    "position" : {
      "x" : 762,
      "y" : 37
    },
    "minX" : 710,
    "maxX" : 815,
    "minY" : 26,
    "maxY" : 49,
    "prop" : {
      "x" : 710,
      "y" : 26,
      "width" : 105,
      "height" : 23
    },
    "textPosition" : {
      "x" : 719,
      "y" : 27
    }
  }, {
    "id" : 19434,
    "displayName" : "Proximal tubule, descending thin  limb of Henle",
    "renderableClass" : "Note",
    "position" : {
      "x" : 382,
      "y" : 57
    },
    "minX" : 219,
    "maxX" : 546,
    "minY" : 37,
    "maxY" : 77,
    "prop" : {
      "x" : 219,
      "y" : 37,
      "width" : 327,
      "height" : 40
    },
    "textPosition" : {
      "x" : 231,
      "y" : 46
    }
  }, {
    "id" : 19435,
    "displayName" : "Collecting duct",
    "renderableClass" : "Note",
    "position" : {
      "x" : 381,
      "y" : 308
    },
    "minX" : 293,
    "maxX" : 470,
    "minY" : 287,
    "maxY" : 330,
    "prop" : {
      "x" : 293,
      "y" : 287,
      "width" : 177,
      "height" : 43
    },
    "textPosition" : {
      "x" : 331,
      "y" : 298
    }
  } ],
  "links" : [ ],
  "shadows" : [ ],
  "minX" : 0,
  "maxX" : 815,
  "minY" : 0,
  "maxY" : 1806,
  "disease" : false
}