{ "dbId" : 11079141, "stableId" : "R-SPO-428157", "displayName" : "Sphingolipid metabolism", "nodes" : [ { "id" : 45440, "reactomeId" : 428040, "displayName" : "H+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2568, "y" : 899 }, "minX" : 2497, "maxX" : 2587, "minY" : 878, "maxY" : 915, "prop" : { "x" : 2550, "y" : 884, "width" : 36, "height" : 31 }, "textPosition" : { "x" : 2554, "y" : 889 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2581, "y" : 889 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2581, "y" : 889 } } }, "connectors" : [ { "edgeId" : 45435, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 2547, "y" : 893 }, "to" : { "x" : 2497, "y" : 878 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2539, "y" : 895 }, "b" : { "x" : 2547, "y" : 893 }, "c" : { "x" : 2542, "y" : 887 }, "type" : "ARROW", "centre" : { "x" : 2542, "y" : 887 } } } ], "trivial" : true }, { "id" : 45441, "reactomeId" : 11062924, "displayName" : "ppn1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 2572, "y" : 856 }, "minX" : 2506, "maxX" : 2603, "minY" : 839, "maxY" : 868, "prop" : { "x" : 2548, "y" : 845, "width" : 49, "height" : 23 }, "textPosition" : { "x" : 2552, "y" : 846 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2597, "y" : 845 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2597, "y" : 845 } } }, "connectors" : [ { "edgeId" : 45435, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 2545, "y" : 856 }, "to" : { "x" : 2514, "y" : 857 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 2510, "y" : 857 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2510, "y" : 857 } } } ] }, { "id" : 45443, "reactomeId" : 429776, "displayName" : "SPHM d18:1", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 68, "y" : 380 }, "minX" : 6, "maxX" : 168, "minY" : 363, "maxY" : 425, "prop" : { "x" : 24, "y" : 365, "width" : 89, "height" : 31 }, "textPosition" : { "x" : 27, "y" : 370 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 108, "y" : 370 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 108, "y" : 370 } } }, "connectors" : [ { "edgeId" : 45442, "type" : "INPUT", "segments" : [ { "from" : { "x" : 21, "y" : 367 }, "to" : { "x" : 6, "y" : 363 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 45449, "type" : "INPUT", "segments" : [ { "from" : { "x" : 102, "y" : 399 }, "to" : { "x" : 168, "y" : 425 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 45444, "reactomeId" : 29356, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 161, "y" : 353 }, "minX" : 6, "maxX" : 184, "minY" : 337, "maxY" : 425, "prop" : { "x" : 140, "y" : 338, "width" : 43, "height" : 31 }, "textPosition" : { "x" : 144, "y" : 343 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 178, "y" : 343 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 178, "y" : 343 } } }, "connectors" : [ { "edgeId" : 45442, "type" : "INPUT", "segments" : [ { "from" : { "x" : 137, "y" : 354 }, "to" : { "x" : 6, "y" : 363 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 45449, "type" : "INPUT", "segments" : [ { "from" : { "x" : 162, "y" : 372 }, "to" : { "x" : 168, "y" : 425 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 45445, "reactomeId" : 429807, "displayName" : "CERA", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 73, "y" : 506 }, "minX" : 33, "maxX" : 164, "minY" : 487, "maxY" : 530, "prop" : { "x" : 49, "y" : 491, "width" : 48, "height" : 31 }, "textPosition" : { "x" : 53, "y" : 496 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 92, "y" : 496 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 92, "y" : 496 } } }, "connectors" : [ { "edgeId" : 45442, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 46, "y" : 520 }, "to" : { "x" : 33, "y" : 530 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 43, "y" : 527 }, "b" : { "x" : 46, "y" : 520 }, "c" : { "x" : 38, "y" : 521 }, "type" : "ARROW", "centre" : { "x" : 38, "y" : 521 } } }, { "edgeId" : 45449, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 100, "y" : 500 }, "to" : { "x" : 164, "y" : 487 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 106, "y" : 495 }, "b" : { "x" : 100, "y" : 500 }, "c" : { "x" : 108, "y" : 503 }, "type" : "ARROW", "centre" : { "x" : 108, "y" : 503 } } } ] }, { "id" : 45446, "reactomeId" : 1610735, "displayName" : "ChoP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 81, "y" : 601 }, "minX" : 33, "maxX" : 164, "minY" : 487, "maxY" : 617, "prop" : { "x" : 58, "y" : 586, "width" : 46, "height" : 31 }, "textPosition" : { "x" : 61, "y" : 591 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 99, "y" : 591 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 99, "y" : 591 } } }, "connectors" : [ { "edgeId" : 45442, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 70, "y" : 583 }, "to" : { "x" : 33, "y" : 530 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 63, "y" : 580 }, "b" : { "x" : 70, "y" : 583 }, "c" : { "x" : 69, "y" : 575 }, "type" : "ARROW", "centre" : { "x" : 69, "y" : 575 } } }, { "edgeId" : 45449, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 92, "y" : 583 }, "to" : { "x" : 164, "y" : 487 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 93, "y" : 575 }, "b" : { "x" : 92, "y" : 583 }, "c" : { "x" : 99, "y" : 580 }, "type" : "ARROW", "centre" : { "x" : 99, "y" : 580 } } } ] }, { "id" : 45447, "reactomeId" : 70106, "displayName" : "H+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 161, "y" : 548 }, "minX" : 33, "maxX" : 180, "minY" : 487, "maxY" : 564, "prop" : { "x" : 143, "y" : 533, "width" : 36, "height" : 31 }, "textPosition" : { "x" : 147, "y" : 538 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 174, "y" : 538 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 174, "y" : 538 } } }, "connectors" : [ { "edgeId" : 45442, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 140, "y" : 545 }, "to" : { "x" : 33, "y" : 530 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 133, "y" : 548 }, "b" : { "x" : 140, "y" : 545 }, "c" : { "x" : 134, "y" : 540 }, "type" : "ARROW", "centre" : { "x" : 134, "y" : 540 } } }, { "edgeId" : 45449, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 161, "y" : 530 }, "to" : { "x" : 164, "y" : 487 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 157, "y" : 523 }, "b" : { "x" : 161, "y" : 530 }, "c" : { "x" : 165, "y" : 523 }, "type" : "ARROW", "centre" : { "x" : 165, "y" : 523 } } } ], "trivial" : true }, { "id" : 45448, "reactomeId" : 11062934, "displayName" : "SMPD2,3:Mg2+", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 70, "y" : 645 }, "minX" : 8, "maxX" : 126, "minY" : 549, "maxY" : 657, "prop" : { "x" : 20, "y" : 634, "width" : 100, "height" : 23 }, "textPosition" : { "x" : 36, "y" : 622 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 120, "y" : 634 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 120, "y" : 634 } } }, "connectors" : [ { "edgeId" : 45442, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 62, "y" : 631 }, "to" : { "x" : 15, "y" : 556 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 12, "y" : 553 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 12, "y" : 553 } } } ] }, { "id" : 45576, "reactomeId" : 11079631, "displayName" : "Class A/1 (Rhodopsin-like receptors)", "schemaClass" : "Pathway", "renderableClass" : "EncapsulatedNode", "position" : { "x" : 1351, "y" : 1372 }, "minX" : 1295, "maxX" : 1408, "minY" : 1343, "maxY" : 1402, "prop" : { "x" : 1295, "y" : 1343, "width" : 113, "height" : 59 }, "textPosition" : { "x" : 1294, "y" : 1344 }, "connectors" : [ ] }, { "id" : 45577, "reactomeId" : 9840585, "displayName" : "GM1", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2273, "y" : 25 }, "minX" : 2251, "maxX" : 2296, "minY" : 9, "maxY" : 41, "prop" : { "x" : 2251, "y" : 10, "width" : 44, "height" : 31 }, "textPosition" : { "x" : 2255, "y" : 15 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2290, "y" : 15 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2290, "y" : 15 } } }, "connectors" : [ ] }, { "id" : 45450, "reactomeId" : 11063091, "displayName" : "ENPP7", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 82, "y" : 695 }, "minX" : 59, "maxX" : 199, "minY" : 463, "maxY" : 707, "prop" : { "x" : 59, "y" : 684, "width" : 47, "height" : 23 }, "textPosition" : { "x" : 62, "y" : 678 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 106, "y" : 684 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 106, "y" : 684 } } }, "connectors" : [ { "edgeId" : 45449, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 99, "y" : 681 }, "to" : { "x" : 149, "y" : 652 } }, { "from" : { "x" : 149, "y" : 652 }, "to" : { "x" : 149, "y" : 590 } }, { "from" : { "x" : 149, "y" : 590 }, "to" : { "x" : 189, "y" : 566 } }, { "from" : { "x" : 189, "y" : 566 }, "to" : { "x" : 199, "y" : 466 } }, { "from" : { "x" : 199, "y" : 466 }, "to" : { "x" : 186, "y" : 466 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 182, "y" : 467 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 182, "y" : 467 } } } ] }, { "id" : 45452, "reactomeId" : 11062971, "displayName" : "active ARSA:Ca2+", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 788, "y" : 1219 }, "minX" : 732, "maxX" : 851, "minY" : 1202, "maxY" : 1231, "prop" : { "x" : 732, "y" : 1208, "width" : 113, "height" : 23 }, "textPosition" : { "x" : 746, "y" : 1196 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 845, "y" : 1208 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 845, "y" : 1208 } } }, "connectors" : [ { "edgeId" : 45451, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 45453, "reactomeId" : 11063969, "displayName" : "active ARSA:Ca2+", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2085, "y" : 771 }, "minX" : 2029, "maxX" : 2148, "minY" : 754, "maxY" : 783, "prop" : { "x" : 2029, "y" : 760, "width" : 113, "height" : 23 }, "textPosition" : { "x" : 2043, "y" : 748 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2142, "y" : 760 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2142, "y" : 760 } } }, "connectors" : [ { "edgeId" : 45451, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 45454, "reactomeId" : 11063974, "displayName" : "M6PR", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1700, "y" : 796 }, "minX" : 1679, "maxX" : 1811, "minY" : 779, "maxY" : 860, "prop" : { "x" : 1679, "y" : 785, "width" : 42, "height" : 23 }, "textPosition" : { "x" : 1679, "y" : 786 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1721, "y" : 785 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1721, "y" : 785 } } }, "connectors" : [ { "edgeId" : 45451, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1724, "y" : 807 }, "to" : { "x" : 1803, "y" : 854 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1807, "y" : 856 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1807, "y" : 856 } } } ] }, { "id" : 45582, "reactomeId" : 11079197, "displayName" : "Sialic acid metabolism", "schemaClass" : "Pathway", "renderableClass" : "EncapsulatedNode", "position" : { "x" : 2126, "y" : 22 }, "minX" : 2084, "maxX" : 2168, "minY" : 0, "maxY" : 45, "prop" : { "x" : 2084, "y" : 0, "width" : 84, "height" : 45 }, "textPosition" : { "x" : 2085, "y" : -6 }, "connectors" : [ ] }, { "id" : 45456, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1026, "y" : 678 }, "minX" : 1006, "maxX" : 1065, "minY" : 662, "maxY" : 694, "prop" : { "x" : 1006, "y" : 663, "width" : 40, "height" : 31 }, "textPosition" : { "x" : 1010, "y" : 668 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1041, "y" : 668 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1041, "y" : 668 } } }, "connectors" : [ { "edgeId" : 45455, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1049, "y" : 680 }, "to" : { "x" : 1065, "y" : 683 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 45457, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1312, "y" : 676 }, "minX" : 1184, "maxX" : 1334, "minY" : 660, "maxY" : 692, "prop" : { "x" : 1292, "y" : 661, "width" : 41, "height" : 31 }, "textPosition" : { "x" : 1296, "y" : 666 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1328, "y" : 666 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1328, "y" : 666 } } }, "connectors" : [ { "edgeId" : 45455, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1289, "y" : 676 }, "to" : { "x" : 1184, "y" : 681 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1282, "y" : 680 }, "b" : { "x" : 1289, "y" : 676 }, "c" : { "x" : 1282, "y" : 672 }, "type" : "ARROW", "centre" : { "x" : 1282, "y" : 672 } } } ] }, { "id" : 45458, "reactomeId" : 70106, "displayName" : "H+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1278, "y" : 643 }, "minX" : 1184, "maxX" : 1297, "minY" : 627, "maxY" : 681, "prop" : { "x" : 1260, "y" : 628, "width" : 36, "height" : 31 }, "textPosition" : { "x" : 1264, "y" : 633 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1291, "y" : 633 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1291, "y" : 633 } } }, "connectors" : [ { "edgeId" : 45455, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1257, "y" : 650 }, "to" : { "x" : 1184, "y" : 681 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1252, "y" : 656 }, "b" : { "x" : 1257, "y" : 650 }, "c" : { "x" : 1249, "y" : 649 }, "type" : "ARROW", "centre" : { "x" : 1249, "y" : 649 } } } ], "trivial" : true }, { "id" : 45459, "reactomeId" : 11075972, "displayName" : "Homologues of SPHK2", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1134, "y" : 626 }, "minX" : 1111, "maxX" : 1198, "minY" : 586, "maxY" : 673, "prop" : { "x" : 1111, "y" : 615, "width" : 47, "height" : 23 }, "textPosition" : { "x" : 1109, "y" : 588 }, "connectors" : [ { "edgeId" : 45455, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1134, "y" : 641 }, "to" : { "x" : 1135, "y" : 665 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1135, "y" : 669 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1135, "y" : 669 } } }, { "edgeId" : 45461, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1152, "y" : 612 }, "to" : { "x" : 1198, "y" : 586 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 45460, "reactomeId" : 11075974, "displayName" : "SPHK2:SPHK2 inhibitors", "schemaClass" : "Complex", "renderableClass" : "ComplexDrug", "position" : { "x" : 1278, "y" : 598 }, "minX" : 1142, "maxX" : 1331, "minY" : 574, "maxY" : 680, "prop" : { "x" : 1232, "y" : 580, "width" : 93, "height" : 37 }, "textPosition" : { "x" : 1231, "y" : 582 }, "bgColor" : { "r" : 184, "g" : 154, "b" : 230 }, "fgColor" : { "r" : 161, "g" : 1, "b" : 2 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1325, "y" : 580 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1325, "y" : 580 } } }, "connectors" : [ { "edgeId" : 45455, "type" : "INHIBITOR", "segments" : [ { "from" : { "x" : 1246, "y" : 620 }, "to" : { "x" : 1144, "y" : 677 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1142, "y" : 674 }, "b" : { "x" : 1146, "y" : 680 }, "c" : { "x" : 1144, "y" : 677 }, "type" : "STOP", "centre" : { "x" : 1144, "y" : 677 } } }, { "edgeId" : 45461, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 45462, "reactomeId" : 9695954, "displayName" : "SPHK2 inhibitors", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySetDrug", "position" : { "x" : 1283, "y" : 513 }, "minX" : 1198, "maxX" : 1335, "minY" : 502, "maxY" : 586, "prop" : { "x" : 1231, "y" : 502, "width" : 104, "height" : 23 }, "textPosition" : { "x" : 1250, "y" : 496 }, "bgColor" : { "r" : 184, "g" : 154, "b" : 230 }, "fgColor" : { "r" : 161, "g" : 1, "b" : 2 }, "connectors" : [ { "edgeId" : 45461, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1269, "y" : 531 }, "to" : { "x" : 1198, "y" : 586 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 45464, "reactomeId" : 9840879, "displayName" : "SM3", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2361, "y" : 461 }, "minX" : 2341, "maxX" : 2383, "minY" : 445, "maxY" : 517, "prop" : { "x" : 2341, "y" : 446, "width" : 41, "height" : 31 }, "textPosition" : { "x" : 2344, "y" : 451 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2377, "y" : 451 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2377, "y" : 451 } } }, "connectors" : [ { "edgeId" : 45463, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2361, "y" : 480 }, "to" : { "x" : 2361, "y" : 517 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 45465, "reactomeId" : 1605715, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2315, "y" : 490 }, "minX" : 2294, "maxX" : 2361, "minY" : 474, "maxY" : 517, "prop" : { "x" : 2294, "y" : 475, "width" : 43, "height" : 31 }, "textPosition" : { "x" : 2298, "y" : 480 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2332, "y" : 480 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2332, "y" : 480 } } }, "connectors" : [ { "edgeId" : 45463, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2340, "y" : 502 }, "to" : { "x" : 2361, "y" : 517 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 45466, "reactomeId" : 1605601, "displayName" : "LacCer", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2363, "y" : 634 }, "minX" : 2335, "maxX" : 2392, "minY" : 556, "maxY" : 650, "prop" : { "x" : 2335, "y" : 619, "width" : 56, "height" : 31 }, "textPosition" : { "x" : 2338, "y" : 624 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2386, "y" : 624 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2386, "y" : 624 } } }, "connectors" : [ { "edgeId" : 45463, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 2362, "y" : 616 }, "to" : { "x" : 2362, "y" : 556 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2358, "y" : 609 }, "b" : { "x" : 2362, "y" : 616 }, "c" : { "x" : 2366, "y" : 609 }, "type" : "ARROW", "centre" : { "x" : 2366, "y" : 609 } } } ] }, { "id" : 45467, "reactomeId" : 1606845, "displayName" : "SO4(2-)", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2306, "y" : 584 }, "minX" : 2275, "maxX" : 2362, "minY" : 556, "maxY" : 600, "prop" : { "x" : 2275, "y" : 569, "width" : 63, "height" : 31 }, "textPosition" : { "x" : 2279, "y" : 574 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2333, "y" : 574 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2333, "y" : 574 } } }, "connectors" : [ { "edgeId" : 45463, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 2337, "y" : 566 }, "to" : { "x" : 2362, "y" : 556 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2342, "y" : 560 }, "b" : { "x" : 2337, "y" : 566 }, "c" : { "x" : 2345, "y" : 567 }, "type" : "ARROW", "centre" : { "x" : 2345, "y" : 567 } } } ] }, { "id" : 45468, "reactomeId" : 11063969, "displayName" : "active ARSA:Ca2+", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2288, "y" : 537 }, "minX" : 2232, "maxX" : 2353, "minY" : 520, "maxY" : 549, "prop" : { "x" : 2232, "y" : 526, "width" : 113, "height" : 23 }, "textPosition" : { "x" : 2246, "y" : 514 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2345, "y" : 526 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2345, "y" : 526 } } }, "connectors" : [ { "edgeId" : 45463, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 2348, "y" : 535 }, "to" : { "x" : 2345, "y" : 535 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 2349, "y" : 535 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2349, "y" : 535 } } } ] }, { "id" : 45470, "reactomeId" : 29356, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1372, "y" : 1212 }, "minX" : 1351, "maxX" : 1404, "minY" : 1196, "maxY" : 1294, "prop" : { "x" : 1351, "y" : 1197, "width" : 43, "height" : 31 }, "textPosition" : { "x" : 1355, "y" : 1202 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1389, "y" : 1202 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1389, "y" : 1202 } } }, "connectors" : [ { "edgeId" : 45469, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1378, "y" : 1231 }, "to" : { "x" : 1404, "y" : 1294 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 45471, "reactomeId" : 428203, "displayName" : "C18-S1P", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1376, "y" : 689 }, "minX" : 1342, "maxX" : 1524, "minY" : 673, "maxY" : 1294, "prop" : { "x" : 1342, "y" : 674, "width" : 69, "height" : 31 }, "textPosition" : { "x" : 1346, "y" : 679 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1406, "y" : 679 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1406, "y" : 679 } } }, "connectors" : [ { "edgeId" : 45482, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1381, "y" : 708 }, "to" : { "x" : 1524, "y" : 1130 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 45469, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1376, "y" : 708 }, "to" : { "x" : 1404, "y" : 1294 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 45472, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1356, "y" : 1248 }, "minX" : 1336, "maxX" : 1404, "minY" : 1232, "maxY" : 1294, "prop" : { "x" : 1336, "y" : 1233, "width" : 40, "height" : 31 }, "textPosition" : { "x" : 1340, "y" : 1238 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1371, "y" : 1238 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1371, "y" : 1238 } } }, "connectors" : [ { "edgeId" : 45469, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1372, "y" : 1267 }, "to" : { "x" : 1404, "y" : 1294 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 45473, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1477, "y" : 1206 }, "minX" : 1407, "maxX" : 1499, "minY" : 1190, "maxY" : 1295, "prop" : { "x" : 1457, "y" : 1191, "width" : 41, "height" : 31 }, "textPosition" : { "x" : 1461, "y" : 1196 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1493, "y" : 1196 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1493, "y" : 1196 } } }, "connectors" : [ { "edgeId" : 45469, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1464, "y" : 1225 }, "to" : { "x" : 1407, "y" : 1295 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1463, "y" : 1233 }, "b" : { "x" : 1464, "y" : 1225 }, "c" : { "x" : 1457, "y" : 1228 }, "type" : "ARROW", "centre" : { "x" : 1457, "y" : 1228 } } } ] }, { "id" : 45474, "reactomeId" : 419305, "displayName" : "C18-S1P", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1469, "y" : 1339 }, "minX" : 1407, "maxX" : 1527, "minY" : 1295, "maxY" : 1355, "prop" : { "x" : 1435, "y" : 1324, "width" : 69, "height" : 31 }, "textPosition" : { "x" : 1439, "y" : 1329 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1499, "y" : 1329 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1499, "y" : 1329 } } }, "connectors" : [ { "edgeId" : 45487, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1507, "y" : 1339 }, "to" : { "x" : 1527, "y" : 1339 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 45469, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1447, "y" : 1321 }, "to" : { "x" : 1407, "y" : 1295 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1439, "y" : 1321 }, "b" : { "x" : 1447, "y" : 1321 }, "c" : { "x" : 1443, "y" : 1314 }, "type" : "ARROW", "centre" : { "x" : 1443, "y" : 1314 } } } ] }, { "id" : 45475, "reactomeId" : 70106, "displayName" : "H+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1437, "y" : 1177 }, "minX" : 1407, "maxX" : 1456, "minY" : 1161, "maxY" : 1295, "prop" : { "x" : 1419, "y" : 1162, "width" : 36, "height" : 31 }, "textPosition" : { "x" : 1423, "y" : 1167 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1450, "y" : 1167 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1450, "y" : 1167 } } }, "connectors" : [ { "edgeId" : 45469, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1433, "y" : 1196 }, "to" : { "x" : 1407, "y" : 1295 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1435, "y" : 1204 }, "b" : { "x" : 1433, "y" : 1196 }, "c" : { "x" : 1427, "y" : 1202 }, "type" : "ARROW", "centre" : { "x" : 1427, "y" : 1202 } } } ], "trivial" : true }, { "id" : 45476, "reactomeId" : 29372, "displayName" : "Pi", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1510, "y" : 1240 }, "minX" : 1407, "maxX" : 1525, "minY" : 1224, "maxY" : 1295, "prop" : { "x" : 1497, "y" : 1225, "width" : 27, "height" : 31 }, "textPosition" : { "x" : 1501, "y" : 1230 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1519, "y" : 1230 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1519, "y" : 1230 } } }, "connectors" : [ { "edgeId" : 45469, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1494, "y" : 1247 }, "to" : { "x" : 1407, "y" : 1295 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1490, "y" : 1254 }, "b" : { "x" : 1494, "y" : 1247 }, "c" : { "x" : 1486, "y" : 1247 }, "type" : "ARROW", "centre" : { "x" : 1486, "y" : 1247 } } } ] }, { "id" : 45477, "reactomeId" : 11059104, "displayName" : "Homologues of ABCC1", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1323, "y" : 1292 }, "minX" : 1277, "maxX" : 1397, "minY" : 1281, "maxY" : 1304, "prop" : { "x" : 1277, "y" : 1281, "width" : 92, "height" : 23 }, "textPosition" : { "x" : 1278, "y" : 1275 }, "connectors" : [ { "edgeId" : 45469, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1375, "y" : 1292 }, "to" : { "x" : 1389, "y" : 1292 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1393, "y" : 1293 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1393, "y" : 1293 } } } ] }, { "id" : 45479, "reactomeId" : 29356, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1272, "y" : 808 }, "minX" : 1230, "maxX" : 1295, "minY" : 792, "maxY" : 824, "prop" : { "x" : 1251, "y" : 793, "width" : 43, "height" : 31 }, "textPosition" : { "x" : 1255, "y" : 798 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1289, "y" : 798 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1289, "y" : 798 } } }, "connectors" : [ { "edgeId" : 45478, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1248, "y" : 801 }, "to" : { "x" : 1230, "y" : 795 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 45480, "reactomeId" : 29372, "displayName" : "Pi", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 960, "y" : 754 }, "minX" : 947, "maxX" : 1005, "minY" : 738, "maxY" : 770, "prop" : { "x" : 947, "y" : 739, "width" : 27, "height" : 31 }, "textPosition" : { "x" : 951, "y" : 744 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 969, "y" : 744 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 969, "y" : 744 } } }, "connectors" : [ { "edgeId" : 45478, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 977, "y" : 758 }, "to" : { "x" : 1005, "y" : 768 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 985, "y" : 757 }, "b" : { "x" : 977, "y" : 758 }, "c" : { "x" : 982, "y" : 764 }, "type" : "ARROW", "centre" : { "x" : 982, "y" : 764 } } } ] }, { "id" : 45481, "reactomeId" : 11060297, "displayName" : "SGPP", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 938, "y" : 788 }, "minX" : 919, "maxX" : 1004, "minY" : 777, "maxY" : 800, "prop" : { "x" : 919, "y" : 777, "width" : 38, "height" : 23 }, "textPosition" : { "x" : 921, "y" : 771 }, "connectors" : [ { "edgeId" : 45478, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 963, "y" : 787 }, "to" : { "x" : 996, "y" : 786 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1000, "y" : 786 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1000, "y" : 786 } } } ] }, { "id" : 45483, "reactomeId" : 29356, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1480, "y" : 1142 }, "minX" : 1459, "maxX" : 1524, "minY" : 1126, "maxY" : 1158, "prop" : { "x" : 1459, "y" : 1127, "width" : 43, "height" : 31 }, "textPosition" : { "x" : 1463, "y" : 1132 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1497, "y" : 1132 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1497, "y" : 1132 } } }, "connectors" : [ { "edgeId" : 45482, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1505, "y" : 1136 }, "to" : { "x" : 1524, "y" : 1130 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 45484, "reactomeId" : 1132148, "displayName" : "sphingosine", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1610, "y" : 1152 }, "minX" : 1564, "maxX" : 1654, "minY" : 1128, "maxY" : 1330, "prop" : { "x" : 1568, "y" : 1137, "width" : 85, "height" : 31 }, "textPosition" : { "x" : 1568, "y" : 1142 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1648, "y" : 1142 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1648, "y" : 1142 } } }, "connectors" : [ { "edgeId" : 45482, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1576, "y" : 1134 }, "to" : { "x" : 1564, "y" : 1131 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1568, "y" : 1136 }, "b" : { "x" : 1576, "y" : 1134 }, "c" : { "x" : 1570, "y" : 1128 }, "type" : "ARROW", "centre" : { "x" : 1570, "y" : 1128 } } }, { "edgeId" : 45487, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1608, "y" : 1171 }, "to" : { "x" : 1597, "y" : 1330 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1612, "y" : 1178 }, "b" : { "x" : 1608, "y" : 1171 }, "c" : { "x" : 1604, "y" : 1178 }, "type" : "ARROW", "centre" : { "x" : 1604, "y" : 1178 } } } ] }, { "id" : 45485, "reactomeId" : 29372, "displayName" : "Pi", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1597, "y" : 1101 }, "minX" : 1564, "maxX" : 1612, "minY" : 1085, "maxY" : 1131, "prop" : { "x" : 1584, "y" : 1086, "width" : 27, "height" : 31 }, "textPosition" : { "x" : 1588, "y" : 1091 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1606, "y" : 1091 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1606, "y" : 1091 } } }, "connectors" : [ { "edgeId" : 45482, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1581, "y" : 1113 }, "to" : { "x" : 1564, "y" : 1131 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1579, "y" : 1121 }, "b" : { "x" : 1581, "y" : 1113 }, "c" : { "x" : 1573, "y" : 1115 }, "type" : "ARROW", "centre" : { "x" : 1573, "y" : 1115 } } } ] }, { "id" : 45486, "reactomeId" : 11060305, "displayName" : "dpp1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1556, "y" : 1285 }, "minX" : 1522, "maxX" : 1596, "minY" : 1138, "maxY" : 1297, "prop" : { "x" : 1522, "y" : 1274, "width" : 68, "height" : 23 }, "textPosition" : { "x" : 1536, "y" : 1275 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1590, "y" : 1274 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1590, "y" : 1274 } } }, "connectors" : [ { "edgeId" : 45482, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1555, "y" : 1268 }, "to" : { "x" : 1548, "y" : 1146 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1548, "y" : 1142 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1548, "y" : 1142 } } } ] }, { "id" : 45488, "reactomeId" : 109276, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1521, "y" : 1374 }, "minX" : 1500, "maxX" : 1544, "minY" : 1339, "maxY" : 1390, "prop" : { "x" : 1500, "y" : 1359, "width" : 43, "height" : 31 }, "textPosition" : { "x" : 1504, "y" : 1364 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1538, "y" : 1364 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1538, "y" : 1364 } } }, "connectors" : [ { "edgeId" : 45487, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1523, "y" : 1356 }, "to" : { "x" : 1527, "y" : 1339 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 45489, "reactomeId" : 109277, "displayName" : "Pi", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1624, "y" : 1371 }, "minX" : 1597, "maxX" : 1639, "minY" : 1330, "maxY" : 1387, "prop" : { "x" : 1611, "y" : 1356, "width" : 27, "height" : 31 }, "textPosition" : { "x" : 1615, "y" : 1361 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1633, "y" : 1361 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1633, "y" : 1361 } } }, "connectors" : [ { "edgeId" : 45487, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1613, "y" : 1353 }, "to" : { "x" : 1597, "y" : 1330 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1606, "y" : 1350 }, "b" : { "x" : 1613, "y" : 1353 }, "c" : { "x" : 1612, "y" : 1345 }, "type" : "ARROW", "centre" : { "x" : 1612, "y" : 1345 } } } ] }, { "id" : 45490, "reactomeId" : 11060305, "displayName" : "dpp1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1472, "y" : 1292 }, "minX" : 1450, "maxX" : 1543, "minY" : 1275, "maxY" : 1330, "prop" : { "x" : 1450, "y" : 1281, "width" : 44, "height" : 23 }, "textPosition" : { "x" : 1452, "y" : 1282 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1494, "y" : 1281 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1494, "y" : 1281 } } }, "connectors" : [ { "edgeId" : 45487, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1497, "y" : 1303 }, "to" : { "x" : 1536, "y" : 1324 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1539, "y" : 1326 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1539, "y" : 1326 } } } ] }, { "id" : 45619, "reactomeId" : 9843733, "displayName" : "S1P", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1242, "y" : 1368 }, "minX" : 1223, "maxX" : 1262, "minY" : 1352, "maxY" : 1384, "prop" : { "x" : 1223, "y" : 1353, "width" : 38, "height" : 31 }, "textPosition" : { "x" : 1226, "y" : 1358 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1256, "y" : 1358 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1256, "y" : 1358 } } }, "connectors" : [ ] }, { "id" : 45538, "reactomeId" : 1660674, "displayName" : "GlcCer", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 449, "y" : 1199 }, "minX" : 422, "maxX" : 478, "minY" : 1183, "maxY" : 1215, "prop" : { "x" : 422, "y" : 1184, "width" : 55, "height" : 31 }, "textPosition" : { "x" : 425, "y" : 1189 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 472, "y" : 1189 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 472, "y" : 1189 } } }, "connectors" : [ ] }, { "id" : 45671, "reactomeId" : 11079907, "displayName" : "Glycosphingolipid transport", "schemaClass" : "Pathway", "renderableClass" : "EncapsulatedNode", "position" : { "x" : 570, "y" : 1241 }, "minX" : 505, "maxX" : 635, "minY" : 1215, "maxY" : 1268, "prop" : { "x" : 505, "y" : 1215, "width" : 130, "height" : 53 }, "textPosition" : { "x" : 506, "y" : 1220 }, "connectors" : [ ] }, { "id" : 45416, "reactomeId" : 70106, "displayName" : "H+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 583, "y" : 200 }, "minX" : 565, "maxX" : 602, "minY" : 184, "maxY" : 233, "prop" : { "x" : 565, "y" : 185, "width" : 36, "height" : 31 }, "textPosition" : { "x" : 569, "y" : 190 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 596, "y" : 190 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 596, "y" : 190 } } }, "connectors" : [ { "edgeId" : 45415, "type" : "INPUT", "segments" : [ { "from" : { "x" : 588, "y" : 219 }, "to" : { "x" : 595, "y" : 233 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 45417, "reactomeId" : 9841798, "displayName" : "3-ketosphingoid", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 671, "y" : 211 }, "minX" : 595, "maxX" : 729, "minY" : 195, "maxY" : 233, "prop" : { "x" : 615, "y" : 196, "width" : 113, "height" : 31 }, "textPosition" : { "x" : 617, "y" : 201 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 723, "y" : 201 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 723, "y" : 201 } } }, "connectors" : [ { "edgeId" : 45415, "type" : "INPUT", "segments" : [ { "from" : { "x" : 617, "y" : 230 }, "to" : { "x" : 595, "y" : 233 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 45418, "reactomeId" : 29364, "displayName" : "NADPH", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 495, "y" : 231 }, "minX" : 466, "maxX" : 595, "minY" : 215, "maxY" : 247, "prop" : { "x" : 466, "y" : 216, "width" : 59, "height" : 31 }, "textPosition" : { "x" : 470, "y" : 221 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 520, "y" : 221 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 520, "y" : 221 } } }, "connectors" : [ { "edgeId" : 45415, "type" : "INPUT", "segments" : [ { "from" : { "x" : 528, "y" : 231 }, "to" : { "x" : 595, "y" : 233 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 45419, "reactomeId" : 5279323, "displayName" : "sphingoid base", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 537, "y" : 334 }, "minX" : 485, "maxX" : 596, "minY" : 272, "maxY" : 361, "prop" : { "x" : 485, "y" : 319, "width" : 105, "height" : 31 }, "textPosition" : { "x" : 485, "y" : 324 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 585, "y" : 324 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 585, "y" : 324 } } }, "connectors" : [ { "edgeId" : 45415, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 551, "y" : 316 }, "to" : { "x" : 596, "y" : 272 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 553, "y" : 308 }, "b" : { "x" : 551, "y" : 316 }, "c" : { "x" : 559, "y" : 314 }, "type" : "ARROW", "centre" : { "x" : 559, "y" : 314 } } }, { "edgeId" : 45422, "type" : "INPUT", "segments" : [ { "from" : { "x" : 566, "y" : 353 }, "to" : { "x" : 588, "y" : 361 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 45420, "reactomeId" : 29366, "displayName" : "NADP+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 500, "y" : 290 }, "minX" : 470, "maxX" : 596, "minY" : 272, "maxY" : 306, "prop" : { "x" : 470, "y" : 275, "width" : 60, "height" : 31 }, "textPosition" : { "x" : 474, "y" : 280 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 525, "y" : 280 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 525, "y" : 280 } } }, "connectors" : [ { "edgeId" : 45415, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 533, "y" : 284 }, "to" : { "x" : 596, "y" : 272 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 539, "y" : 279 }, "b" : { "x" : 533, "y" : 284 }, "c" : { "x" : 541, "y" : 287 }, "type" : "ARROW", "centre" : { "x" : 541, "y" : 287 } } } ] }, { "id" : 45421, "reactomeId" : 11060239, "displayName" : "KDSR", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 672, "y" : 250 }, "minX" : 604, "maxX" : 698, "minY" : 233, "maxY" : 262, "prop" : { "x" : 652, "y" : 239, "width" : 40, "height" : 23 }, "textPosition" : { "x" : 652, "y" : 240 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 692, "y" : 239 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 692, "y" : 239 } } }, "connectors" : [ { "edgeId" : 45415, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 649, "y" : 250 }, "to" : { "x" : 612, "y" : 251 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 608, "y" : 251 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 608, "y" : 251 } } } ] }, { "id" : 45423, "reactomeId" : 1500578, "displayName" : "acyl-CoA", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 625, "y" : 333 }, "minX" : 588, "maxX" : 661, "minY" : 317, "maxY" : 361, "prop" : { "x" : 591, "y" : 318, "width" : 69, "height" : 31 }, "textPosition" : { "x" : 595, "y" : 323 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 655, "y" : 323 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 655, "y" : 323 } } }, "connectors" : [ { "edgeId" : 45422, "type" : "INPUT", "segments" : [ { "from" : { "x" : 604, "y" : 352 }, "to" : { "x" : 588, "y" : 361 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 45424, "reactomeId" : 428126, "displayName" : "DHCE", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 681, "y" : 465 }, "minX" : 590, "maxX" : 707, "minY" : 407, "maxY" : 481, "prop" : { "x" : 656, "y" : 450, "width" : 50, "height" : 31 }, "textPosition" : { "x" : 660, "y" : 455 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 701, "y" : 455 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 701, "y" : 455 } } }, "connectors" : [ { "edgeId" : 45422, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 656, "y" : 447 }, "to" : { "x" : 590, "y" : 407 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 648, "y" : 447 }, "b" : { "x" : 656, "y" : 447 }, "c" : { "x" : 652, "y" : 440 }, "type" : "ARROW", "centre" : { "x" : 652, "y" : 440 } } } ] }, { "id" : 45425, "reactomeId" : 76194, "displayName" : "CoA-SH", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 527, "y" : 413 }, "minX" : 496, "maxX" : 590, "minY" : 397, "maxY" : 429, "prop" : { "x" : 496, "y" : 398, "width" : 62, "height" : 31 }, "textPosition" : { "x" : 500, "y" : 403 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 553, "y" : 403 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 553, "y" : 403 } } }, "connectors" : [ { "edgeId" : 45422, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 561, "y" : 410 }, "to" : { "x" : 590, "y" : 407 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 567, "y" : 405 }, "b" : { "x" : 561, "y" : 410 }, "c" : { "x" : 568, "y" : 413 }, "type" : "ARROW", "centre" : { "x" : 568, "y" : 413 } } } ] }, { "id" : 45553, "reactomeId" : 11062987, "displayName" : "active ARS", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 779, "y" : 1157 }, "minX" : 745, "maxX" : 813, "minY" : 1146, "maxY" : 1169, "prop" : { "x" : 745, "y" : 1146, "width" : 68, "height" : 23 }, "textPosition" : { "x" : 754, "y" : 1140 }, "connectors" : [ ] }, { "id" : 45426, "reactomeId" : 70106, "displayName" : "H+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 612, "y" : 457 }, "minX" : 590, "maxX" : 631, "minY" : 407, "maxY" : 473, "prop" : { "x" : 594, "y" : 442, "width" : 36, "height" : 31 }, "textPosition" : { "x" : 598, "y" : 447 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 625, "y" : 447 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 625, "y" : 447 } } }, "connectors" : [ { "edgeId" : 45422, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 605, "y" : 439 }, "to" : { "x" : 590, "y" : 407 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 598, "y" : 434 }, "b" : { "x" : 605, "y" : 439 }, "c" : { "x" : 606, "y" : 431 }, "type" : "ARROW", "centre" : { "x" : 606, "y" : 431 } } } ], "trivial" : true }, { "id" : 45427, "reactomeId" : 11060282, "displayName" : "Ceramide synthases", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 670, "y" : 380 }, "minX" : 597, "maxX" : 733, "minY" : 369, "maxY" : 392, "prop" : { "x" : 608, "y" : 369, "width" : 125, "height" : 23 }, "textPosition" : { "x" : 634, "y" : 363 }, "connectors" : [ { "edgeId" : 45422, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 602, "y" : 380 }, "to" : { "x" : 605, "y" : 380 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 601, "y" : 380 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 601, "y" : 380 } } } ] }, { "id" : 45429, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1024, "y" : 745 }, "minX" : 1004, "maxX" : 1050, "minY" : 718, "maxY" : 761, "prop" : { "x" : 1004, "y" : 730, "width" : 40, "height" : 31 }, "textPosition" : { "x" : 1008, "y" : 735 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1039, "y" : 735 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1039, "y" : 735 } } }, "connectors" : [ { "edgeId" : 45428, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1038, "y" : 727 }, "to" : { "x" : 1050, "y" : 718 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 45430, "reactomeId" : 428682, "displayName" : "SPG", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 983, "y" : 721 }, "minX" : 964, "maxX" : 1065, "minY" : 683, "maxY" : 768, "prop" : { "x" : 964, "y" : 706, "width" : 39, "height" : 31 }, "textPosition" : { "x" : 967, "y" : 711 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 998, "y" : 711 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 998, "y" : 711 } } }, "connectors" : [ { "edgeId" : 45478, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 990, "y" : 740 }, "to" : { "x" : 1005, "y" : 768 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 997, "y" : 744 }, "b" : { "x" : 990, "y" : 740 }, "c" : { "x" : 990, "y" : 748 }, "type" : "ARROW", "centre" : { "x" : 990, "y" : 748 } } }, { "edgeId" : 45455, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1006, "y" : 711 }, "to" : { "x" : 1065, "y" : 683 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 45428, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1006, "y" : 720 }, "to" : { "x" : 1050, "y" : 718 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 45431, "reactomeId" : 5279322, "displayName" : "S1P", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1267, "y" : 713 }, "minX" : 1184, "maxX" : 1287, "minY" : 681, "maxY" : 795, "prop" : { "x" : 1248, "y" : 698, "width" : 38, "height" : 31 }, "textPosition" : { "x" : 1251, "y" : 703 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1281, "y" : 703 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1281, "y" : 703 } } }, "connectors" : [ { "edgeId" : 45478, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1260, "y" : 732 }, "to" : { "x" : 1230, "y" : 795 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 45455, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1245, "y" : 705 }, "to" : { "x" : 1184, "y" : 681 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1237, "y" : 706 }, "b" : { "x" : 1245, "y" : 705 }, "c" : { "x" : 1240, "y" : 699 }, "type" : "ARROW", "centre" : { "x" : 1240, "y" : 699 } } }, { "edgeId" : 45428, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1245, "y" : 713 }, "to" : { "x" : 1187, "y" : 717 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1238, "y" : 717 }, "b" : { "x" : 1245, "y" : 713 }, "c" : { "x" : 1238, "y" : 709 }, "type" : "ARROW", "centre" : { "x" : 1238, "y" : 709 } } } ] }, { "id" : 45432, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1207, "y" : 759 }, "minX" : 1187, "maxX" : 1229, "minY" : 717, "maxY" : 775, "prop" : { "x" : 1187, "y" : 744, "width" : 41, "height" : 31 }, "textPosition" : { "x" : 1191, "y" : 749 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1223, "y" : 749 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1223, "y" : 749 } } }, "connectors" : [ { "edgeId" : 45428, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1199, "y" : 741 }, "to" : { "x" : 1187, "y" : 717 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1192, "y" : 737 }, "b" : { "x" : 1199, "y" : 741 }, "c" : { "x" : 1199, "y" : 733 }, "type" : "ARROW", "centre" : { "x" : 1199, "y" : 733 } } } ] }, { "id" : 45433, "reactomeId" : 70106, "displayName" : "H+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1293, "y" : 754 }, "minX" : 1187, "maxX" : 1312, "minY" : 717, "maxY" : 770, "prop" : { "x" : 1275, "y" : 739, "width" : 36, "height" : 31 }, "textPosition" : { "x" : 1279, "y" : 744 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1306, "y" : 744 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1306, "y" : 744 } } }, "connectors" : [ { "edgeId" : 45428, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1272, "y" : 747 }, "to" : { "x" : 1187, "y" : 717 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1264, "y" : 748 }, "b" : { "x" : 1272, "y" : 747 }, "c" : { "x" : 1267, "y" : 741 }, "type" : "ARROW", "centre" : { "x" : 1267, "y" : 741 } } } ], "trivial" : true }, { "id" : 45434, "reactomeId" : 11059817, "displayName" : "Homologues of SPHK1", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1141, "y" : 758 }, "minX" : 1118, "maxX" : 1165, "minY" : 725, "maxY" : 770, "prop" : { "x" : 1118, "y" : 747, "width" : 47, "height" : 23 }, "textPosition" : { "x" : 1116, "y" : 720 }, "connectors" : [ { "edgeId" : 45428, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 1141, "y" : 744 }, "to" : { "x" : 1141, "y" : 733 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 1141, "y" : 729 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1141, "y" : 729 } } } ] }, { "id" : 45436, "reactomeId" : 1605713, "displayName" : "SPHM d18:1", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2510, "y" : 789 }, "minX" : 2466, "maxX" : 2556, "minY" : 773, "maxY" : 836, "prop" : { "x" : 2466, "y" : 774, "width" : 89, "height" : 31 }, "textPosition" : { "x" : 2469, "y" : 779 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2550, "y" : 779 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2550, "y" : 779 } } }, "connectors" : [ { "edgeId" : 45435, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2506, "y" : 808 }, "to" : { "x" : 2498, "y" : 836 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 45565, "reactomeId" : 6785915, "displayName" : "GalCer", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 669, "y" : 831 }, "minX" : 641, "maxX" : 698, "minY" : 815, "maxY" : 847, "prop" : { "x" : 641, "y" : 816, "width" : 56, "height" : 31 }, "textPosition" : { "x" : 644, "y" : 821 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 692, "y" : 821 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 692, "y" : 821 } } }, "connectors" : [ ] }, { "id" : 45437, "reactomeId" : 1605715, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2596, "y" : 818 }, "minX" : 2498, "maxX" : 2619, "minY" : 802, "maxY" : 836, "prop" : { "x" : 2575, "y" : 803, "width" : 43, "height" : 31 }, "textPosition" : { "x" : 2579, "y" : 808 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2613, "y" : 808 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2613, "y" : 808 } } }, "connectors" : [ { "edgeId" : 45435, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2572, "y" : 821 }, "to" : { "x" : 2498, "y" : 836 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 45438, "reactomeId" : 1605673, "displayName" : "CERA", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2356, "y" : 976 }, "minX" : 2332, "maxX" : 2497, "minY" : 878, "maxY" : 992, "prop" : { "x" : 2332, "y" : 961, "width" : 48, "height" : 31 }, "textPosition" : { "x" : 2336, "y" : 966 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2375, "y" : 966 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2375, "y" : 966 } } }, "connectors" : [ { "edgeId" : 45435, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 2378, "y" : 958 }, "to" : { "x" : 2497, "y" : 878 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2382, "y" : 951 }, "b" : { "x" : 2378, "y" : 958 }, "c" : { "x" : 2386, "y" : 957 }, "type" : "ARROW", "centre" : { "x" : 2386, "y" : 957 } } } ] }, { "id" : 45439, "reactomeId" : 1605750, "displayName" : "ChoP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 2498, "y" : 928 }, "minX" : 2475, "maxX" : 2522, "minY" : 878, "maxY" : 944, "prop" : { "x" : 2475, "y" : 913, "width" : 46, "height" : 31 }, "textPosition" : { "x" : 2478, "y" : 918 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2516, "y" : 918 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2516, "y" : 918 } } }, "connectors" : [ { "edgeId" : 45435, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 2497, "y" : 910 }, "to" : { "x" : 2497, "y" : 878 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 2493, "y" : 903 }, "b" : { "x" : 2497, "y" : 910 }, "c" : { "x" : 2501, "y" : 903 }, "type" : "ARROW", "centre" : { "x" : 2501, "y" : 903 } } } ] } ], "edges" : [ { "id" : 45442, "reactomeId" : 11062937, "displayName" : "SMPD2 and 3 hydrolyze sphingomyelin (plasma membrane)", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 6, "y" : 543 }, "minX" : 0, "maxX" : 33, "minY" : 363, "maxY" : 549, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 6, "y" : 363 }, "to" : { "x" : 6, "y" : 543 } }, { "from" : { "x" : 6, "y" : 543 }, "to" : { "x" : 33, "y" : 530 } } ], "reactionShape" : { "a" : { "x" : 0, "y" : 537 }, "b" : { "x" : 12, "y" : 549 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 6, "y" : 543 } }, "inputs" : [ { "id" : 45443, "points" : [ { "x" : 21, "y" : 367 } ] }, { "id" : 45444, "points" : [ { "x" : 137, "y" : 354 } ] } ], "outputs" : [ { "id" : 45445, "points" : [ { "x" : 46, "y" : 520 } ] }, { "id" : 45446, "points" : [ { "x" : 70, "y" : 583 } ] }, { "id" : 45447, "points" : [ { "x" : 140, "y" : 545 } ] } ], "catalysts" : [ { "id" : 45448, "points" : [ { "x" : 62, "y" : 631 } ] } ] }, { "id" : 45478, "reactomeId" : 11060300, "displayName" : "SGPP1,2 dephosphorylate sphingoid-1-phosphates", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1012, "y" : 786 }, "minX" : 1005, "maxX" : 1230, "minY" : 768, "maxY" : 795, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1230, "y" : 795 }, "to" : { "x" : 1012, "y" : 786 } }, { "from" : { "x" : 1012, "y" : 786 }, "to" : { "x" : 1005, "y" : 768 } } ], "reactionShape" : { "a" : { "x" : 1006, "y" : 780 }, "b" : { "x" : 1018, "y" : 792 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1012, "y" : 786 } }, "inputs" : [ { "id" : 45431, "points" : [ { "x" : 1260, "y" : 732 } ] }, { "id" : 45479, "points" : [ { "x" : 1248, "y" : 801 } ] } ], "outputs" : [ { "id" : 45480, "points" : [ { "x" : 977, "y" : 758 } ] }, { "id" : 45430, "points" : [ { "x" : 990, "y" : 740 } ] } ], "catalysts" : [ { "id" : 45481, "points" : [ { "x" : 963, "y" : 787 } ] } ] }, { "id" : 45415, "reactomeId" : 11060242, "displayName" : "KDSR reduces 3-ketosphingoid", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 596, "y" : 251 }, "minX" : 590, "maxX" : 602, "minY" : 233, "maxY" : 272, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 595, "y" : 233 }, "to" : { "x" : 596, "y" : 251 } }, { "from" : { "x" : 596, "y" : 251 }, "to" : { "x" : 596, "y" : 272 } } ], "reactionShape" : { "a" : { "x" : 590, "y" : 245 }, "b" : { "x" : 602, "y" : 257 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 596, "y" : 251 } }, "inputs" : [ { "id" : 45416, "points" : [ { "x" : 588, "y" : 219 } ] }, { "id" : 45417, "points" : [ { "x" : 617, "y" : 230 } ] }, { "id" : 45418, "points" : [ { "x" : 528, "y" : 231 } ] } ], "outputs" : [ { "id" : 45419, "points" : [ { "x" : 551, "y" : 316 } ] }, { "id" : 45420, "points" : [ { "x" : 533, "y" : 284 } ] } ], "catalysts" : [ { "id" : 45421, "points" : [ { "x" : 649, "y" : 250 } ] } ] }, { "id" : 45449, "reactomeId" : 11063094, "displayName" : "ENPP7 hydrolyzes sphingomyelin", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 170, "y" : 467 }, "minX" : 164, "maxX" : 176, "minY" : 425, "maxY" : 487, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 168, "y" : 425 }, "to" : { "x" : 170, "y" : 467 } }, { "from" : { "x" : 170, "y" : 467 }, "to" : { "x" : 164, "y" : 487 } } ], "reactionShape" : { "a" : { "x" : 164, "y" : 461 }, "b" : { "x" : 176, "y" : 473 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 170, "y" : 467 } }, "inputs" : [ { "id" : 45443, "points" : [ { "x" : 102, "y" : 399 } ] }, { "id" : 45444, "points" : [ { "x" : 162, "y" : 372 } ] } ], "outputs" : [ { "id" : 45445, "points" : [ { "x" : 100, "y" : 500 } ] }, { "id" : 45446, "points" : [ { "x" : 92, "y" : 583 } ] }, { "id" : 45447, "points" : [ { "x" : 161, "y" : 530 } ] } ], "catalysts" : [ { "id" : 45450, "points" : [ { "x" : 99, "y" : 681 }, { "x" : 149, "y" : 652 }, { "x" : 149, "y" : 590 }, { "x" : 189, "y" : 566 }, { "x" : 199, "y" : 466 } ] } ] }, { "id" : 45482, "reactomeId" : 11060314, "displayName" : "PLPP1,2,3 dephosphorylate cytosolic sphingosine-1-phosphate", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1547, "y" : 1130 }, "minX" : 1524, "maxX" : 1564, "minY" : 1124, "maxY" : 1136, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1524, "y" : 1130 }, "to" : { "x" : 1547, "y" : 1130 } }, { "from" : { "x" : 1547, "y" : 1130 }, "to" : { "x" : 1564, "y" : 1131 } } ], "reactionShape" : { "a" : { "x" : 1541, "y" : 1124 }, "b" : { "x" : 1553, "y" : 1136 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1547, "y" : 1130 } }, "inputs" : [ { "id" : 45483, "points" : [ { "x" : 1505, "y" : 1136 } ] }, { "id" : 45471, "points" : [ { "x" : 1381, "y" : 708 } ] } ], "outputs" : [ { "id" : 45484, "points" : [ { "x" : 1576, "y" : 1134 } ] }, { "id" : 45485, "points" : [ { "x" : 1581, "y" : 1113 } ] } ], "catalysts" : [ { "id" : 45486, "points" : [ { "x" : 1555, "y" : 1268 } ] } ] }, { "id" : 45451, "reactomeId" : 11063977, "displayName" : "M6PR transports activated ARSA to the lysosome", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1817, "y" : 862 }, "minX" : 799, "maxX" : 2026, "minY" : 779, "maxY" : 1420, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 799, "y" : 1234 }, "to" : { "x" : 991, "y" : 1415 } }, { "from" : { "x" : 991, "y" : 1415 }, "to" : { "x" : 1813, "y" : 1420 } }, { "from" : { "x" : 1813, "y" : 1420 }, "to" : { "x" : 1817, "y" : 862 } }, { "from" : { "x" : 1817, "y" : 862 }, "to" : { "x" : 1818, "y" : 809 } }, { "from" : { "x" : 1818, "y" : 809 }, "to" : { "x" : 2026, "y" : 779 } } ], "endShape" : { "a" : { "x" : 2020, "y" : 784 }, "b" : { "x" : 2026, "y" : 779 }, "c" : { "x" : 2019, "y" : 776 }, "type" : "ARROW", "centre" : { "x" : 2019, "y" : 776 } }, "reactionShape" : { "a" : { "x" : 1811, "y" : 856 }, "b" : { "x" : 1823, "y" : 868 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1817, "y" : 862 } }, "inputs" : [ { "id" : 45452 } ], "outputs" : [ { "id" : 45453 } ], "catalysts" : [ { "id" : 45454, "points" : [ { "x" : 1724, "y" : 807 } ] } ] }, { "id" : 45422, "reactomeId" : 11060285, "displayName" : "Ceramide synthases transfer acyl-CoA onto sphingoid", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 589, "y" : 380 }, "minX" : 583, "maxX" : 595, "minY" : 361, "maxY" : 407, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 588, "y" : 361 }, "to" : { "x" : 589, "y" : 380 } }, { "from" : { "x" : 589, "y" : 380 }, "to" : { "x" : 590, "y" : 407 } } ], "reactionShape" : { "a" : { "x" : 583, "y" : 374 }, "b" : { "x" : 595, "y" : 386 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 589, "y" : 380 } }, "inputs" : [ { "id" : 45419, "points" : [ { "x" : 566, "y" : 353 } ] }, { "id" : 45423, "points" : [ { "x" : 604, "y" : 352 } ] } ], "outputs" : [ { "id" : 45424, "points" : [ { "x" : 656, "y" : 447 } ] }, { "id" : 45425, "points" : [ { "x" : 561, "y" : 410 } ] }, { "id" : 45426, "points" : [ { "x" : 605, "y" : 439 } ] } ], "catalysts" : [ { "id" : 45427, "points" : [ { "x" : 602, "y" : 380 } ] } ] }, { "id" : 45455, "reactomeId" : 11075979, "displayName" : "SPHK2 phosphorylates sphingoid", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1136, "y" : 681 }, "minX" : 1065, "maxX" : 1184, "minY" : 675, "maxY" : 687, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1065, "y" : 683 }, "to" : { "x" : 1136, "y" : 681 } }, { "from" : { "x" : 1136, "y" : 681 }, "to" : { "x" : 1184, "y" : 681 } } ], "reactionShape" : { "a" : { "x" : 1130, "y" : 675 }, "b" : { "x" : 1142, "y" : 687 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1136, "y" : 681 } }, "inputs" : [ { "id" : 45456, "points" : [ { "x" : 1049, "y" : 680 } ] }, { "id" : 45430, "points" : [ { "x" : 1006, "y" : 711 } ] } ], "outputs" : [ { "id" : 45431, "points" : [ { "x" : 1245, "y" : 705 } ] }, { "id" : 45457, "points" : [ { "x" : 1289, "y" : 676 } ] }, { "id" : 45458, "points" : [ { "x" : 1257, "y" : 650 } ] } ], "catalysts" : [ { "id" : 45459, "points" : [ { "x" : 1134, "y" : 641 } ] } ], "inhibitors" : [ { "id" : 45460, "points" : [ { "x" : 1246, "y" : 620 } ] } ] }, { "id" : 45487, "reactomeId" : 11060308, "displayName" : "PLPP1 dephosphorylates extracellular sphingosine-1-phosphate", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1550, "y" : 1332 }, "minX" : 1527, "maxX" : 1597, "minY" : 1326, "maxY" : 1339, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1527, "y" : 1339 }, "to" : { "x" : 1550, "y" : 1332 } }, { "from" : { "x" : 1550, "y" : 1332 }, "to" : { "x" : 1597, "y" : 1330 } } ], "reactionShape" : { "a" : { "x" : 1544, "y" : 1326 }, "b" : { "x" : 1556, "y" : 1338 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1550, "y" : 1332 } }, "inputs" : [ { "id" : 45474, "points" : [ { "x" : 1507, "y" : 1339 } ] }, { "id" : 45488, "points" : [ { "x" : 1523, "y" : 1356 } ] } ], "outputs" : [ { "id" : 45489, "points" : [ { "x" : 1613, "y" : 1353 } ] }, { "id" : 45484, "points" : [ { "x" : 1608, "y" : 1171 } ] } ], "catalysts" : [ { "id" : 45490, "points" : [ { "x" : 1497, "y" : 1303 } ] } ] }, { "id" : 45428, "reactomeId" : 11060288, "displayName" : "SPHK1 phosphorylates sphingoid", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1141, "y" : 717 }, "minX" : 1050, "maxX" : 1187, "minY" : 711, "maxY" : 723, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1050, "y" : 718 }, "to" : { "x" : 1141, "y" : 717 } }, { "from" : { "x" : 1141, "y" : 717 }, "to" : { "x" : 1187, "y" : 717 } } ], "reactionShape" : { "a" : { "x" : 1135, "y" : 711 }, "b" : { "x" : 1147, "y" : 723 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1141, "y" : 717 } }, "inputs" : [ { "id" : 45429, "points" : [ { "x" : 1038, "y" : 727 } ] }, { "id" : 45430, "points" : [ { "x" : 1006, "y" : 720 } ] } ], "outputs" : [ { "id" : 45431, "points" : [ { "x" : 1245, "y" : 713 } ] }, { "id" : 45432, "points" : [ { "x" : 1199, "y" : 741 } ] }, { "id" : 45433, "points" : [ { "x" : 1272, "y" : 747 } ] } ], "catalysts" : [ { "id" : 45434, "points" : [ { "x" : 1141, "y" : 744 } ] } ] }, { "id" : 45461, "reactomeId" : 11075976, "displayName" : "SPHK2 binds SPHK2 inhibitors", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1198, "y" : 587 }, "minX" : 1192, "maxX" : 1229, "minY" : 581, "maxY" : 593, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1198, "y" : 586 }, "to" : { "x" : 1198, "y" : 587 } }, { "from" : { "x" : 1198, "y" : 587 }, "to" : { "x" : 1229, "y" : 591 } } ], "endShape" : { "a" : { "x" : 1222, "y" : 594 }, "b" : { "x" : 1229, "y" : 591 }, "c" : { "x" : 1223, "y" : 586 }, "type" : "ARROW", "centre" : { "x" : 1223, "y" : 586 } }, "reactionShape" : { "c" : { "x" : 1198, "y" : 587 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1198, "y" : 587 } }, "inputs" : [ { "id" : 45459, "points" : [ { "x" : 1152, "y" : 612 } ] }, { "id" : 45462, "points" : [ { "x" : 1269, "y" : 531 } ] } ], "outputs" : [ { "id" : 45460 } ] }, { "id" : 45463, "reactomeId" : 11077235, "displayName" : "ARSA removes sulfate from SM3", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2361, "y" : 535 }, "minX" : 2355, "maxX" : 2367, "minY" : 517, "maxY" : 556, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 2361, "y" : 517 }, "to" : { "x" : 2361, "y" : 535 } }, { "from" : { "x" : 2361, "y" : 535 }, "to" : { "x" : 2362, "y" : 556 } } ], "reactionShape" : { "a" : { "x" : 2355, "y" : 529 }, "b" : { "x" : 2367, "y" : 541 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2361, "y" : 535 } }, "inputs" : [ { "id" : 45464, "points" : [ { "x" : 2361, "y" : 480 } ] }, { "id" : 45465, "points" : [ { "x" : 2340, "y" : 502 } ] } ], "outputs" : [ { "id" : 45466, "points" : [ { "x" : 2362, "y" : 616 } ] }, { "id" : 45467, "points" : [ { "x" : 2337, "y" : 566 } ] } ], "catalysts" : [ { "id" : 45468, "points" : [ { "x" : 2348, "y" : 535 } ] } ] }, { "id" : 45435, "reactomeId" : 11062927, "displayName" : "SMPD1 hydrolyzes SPHM", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2498, "y" : 857 }, "minX" : 2492, "maxX" : 2504, "minY" : 836, "maxY" : 878, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 2498, "y" : 836 }, "to" : { "x" : 2498, "y" : 857 } }, { "from" : { "x" : 2498, "y" : 857 }, "to" : { "x" : 2497, "y" : 878 } } ], "reactionShape" : { "a" : { "x" : 2492, "y" : 851 }, "b" : { "x" : 2504, "y" : 863 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2498, "y" : 857 } }, "inputs" : [ { "id" : 45436, "points" : [ { "x" : 2506, "y" : 808 } ] }, { "id" : 45437, "points" : [ { "x" : 2572, "y" : 821 } ] } ], "outputs" : [ { "id" : 45438, "points" : [ { "x" : 2378, "y" : 958 } ] }, { "id" : 45439, "points" : [ { "x" : 2497, "y" : 910 } ] }, { "id" : 45440, "points" : [ { "x" : 2547, "y" : 893 } ] } ], "catalysts" : [ { "id" : 45441, "points" : [ { "x" : 2545, "y" : 856 } ] } ] }, { "id" : 45469, "reactomeId" : 11077246, "displayName" : "ABCC1,ABCG2 transport C18-S1P to extracellular region", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1405, "y" : 1293 }, "minX" : 1399, "maxX" : 1411, "minY" : 1287, "maxY" : 1299, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 1404, "y" : 1294 }, "to" : { "x" : 1405, "y" : 1293 } }, { "from" : { "x" : 1405, "y" : 1293 }, "to" : { "x" : 1407, "y" : 1295 } } ], "reactionShape" : { "a" : { "x" : 1399, "y" : 1287 }, "b" : { "x" : 1411, "y" : 1299 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1405, "y" : 1293 } }, "inputs" : [ { "id" : 45470, "points" : [ { "x" : 1378, "y" : 1231 } ] }, { "id" : 45471, "points" : [ { "x" : 1376, "y" : 708 } ] }, { "id" : 45472, "points" : [ { "x" : 1372, "y" : 1267 } ] } ], "outputs" : [ { "id" : 45473, "points" : [ { "x" : 1464, "y" : 1225 } ] }, { "id" : 45474, "points" : [ { "x" : 1447, "y" : 1321 } ] }, { "id" : 45475, "points" : [ { "x" : 1433, "y" : 1196 } ] }, { "id" : 45476, "points" : [ { "x" : 1494, "y" : 1247 } ] } ], "catalysts" : [ { "id" : 45477, "points" : [ { "x" : 1375, "y" : 1292 } ] } ] } ], "compartments" : [ { "id" : 45602, "reactomeId" : 432051, "displayName" : "transport vesicle", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 1691, "y" : 736 }, "minX" : 1616, "maxX" : 1767, "minY" : 671, "maxY" : 802, "prop" : { "x" : 1616, "y" : 671, "width" : 151, "height" : 131 }, "textPosition" : { "x" : 1636, "y" : 719 }, "insets" : { "x" : 1626, "y" : 681, "width" : 131, "height" : 111 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 45454 ] }, { "id" : 45491, "reactomeId" : 70101, "displayName" : "cytosol", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 1464, "y" : 661 }, "minX" : 73, "maxX" : 2855, "minY" : 24, "maxY" : 1299, "prop" : { "x" : 73, "y" : 24, "width" : 2782, "height" : 1275 }, "textPosition" : { "x" : 581, "y" : 1103 }, "insets" : { "x" : 83, "y" : 34, "width" : 2762, "height" : 1255 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 45415, 45422, 45425, 45426, 45428, 45501, 45502, 45486, 45490, 45512, 45532, 45418, 45416, 45420, 45444, 45471, 45673, 45566, 45539, 45434, 45455, 45459, 45461, 45462, 45460, 45579, 45577, 45582, 45602, 45451, 45447, 45419, 45423, 45431, 45432, 45433, 45429, 45430, 45457, 45458, 45469, 45470, 45472, 45473, 45477, 45475, 45476, 45479, 45456, 45684, 45685, 45686, 45445, 45443, 45448, 45446, 45450, 45449, 45478, 45480, 45482, 45483, 45485, 45484, 45671, 45691, 45692, 45687, 45690, 45688 ] }, { "id" : 45539, "reactomeId" : 17957, "displayName" : "endoplasmic reticulum lumen", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 803, "y" : 675 }, "minX" : 667, "maxX" : 940, "minY" : 87, "maxY" : 1263, "prop" : { "x" : 667, "y" : 87, "width" : 273, "height" : 1176 }, "textPosition" : { "x" : 690, "y" : 305 }, "insets" : { "x" : 677, "y" : 97, "width" : 253, "height" : 1156 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 45481, 45421, 45427, 45424, 45553, 45452, 45674, 45417, 45565 ] }, { "id" : 45512, "reactomeId" : 161320, "displayName" : "lysosomal lumen", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 2326, "y" : 724 }, "minX" : 1831, "maxX" : 2822, "minY" : 182, "maxY" : 1267, "prop" : { "x" : 1831, "y" : 182, "width" : 991, "height" : 1085 }, "textPosition" : { "x" : 2434, "y" : 228 }, "insets" : { "x" : 1841, "y" : 192, "width" : 971, "height" : 1065 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 45466, 45438, 45441, 45435, 45436, 45439, 45675, 45580, 45678, 45679, 45467, 45463, 45468, 45465, 45464, 45453, 45681, 45437, 45440 ] }, { "id" : 45579, "reactomeId" : 17940, "displayName" : "endosome", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 2468, "y" : 105 }, "minX" : 2344, "maxX" : 2592, "minY" : 51, "maxY" : 159, "prop" : { "x" : 2344, "y" : 51, "width" : 248, "height" : 108 }, "textPosition" : { "x" : 2429, "y" : 88 }, "insets" : { "x" : 2354, "y" : 61, "width" : 228, "height" : 88 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 } }, { "id" : 45580, "reactomeId" : 3828050, "displayName" : "multivesicular body, internal vesicle", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 2724, "y" : 402 }, "minX" : 2643, "maxX" : 2806, "minY" : 200, "maxY" : 605, "prop" : { "x" : 2643, "y" : 200, "width" : 163, "height" : 405 }, "textPosition" : { "x" : 2657, "y" : 213 }, "insets" : { "x" : 2653, "y" : 210, "width" : 143, "height" : 385 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 45581, 45680, 45682 ] }, { "id" : 45532, "reactomeId" : 17963, "displayName" : "Golgi lumen", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 338, "y" : 681 }, "minX" : 222, "maxX" : 455, "minY" : 97, "maxY" : 1266, "prop" : { "x" : 222, "y" : 97, "width" : 233, "height" : 1169 }, "textPosition" : { "x" : 358, "y" : 1216 }, "insets" : { "x" : 232, "y" : 107, "width" : 213, "height" : 1149 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 45538, 45689 ] }, { "id" : 45566, "reactomeId" : 13977, "displayName" : "lipid droplet", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 1684, "y" : 456 }, "minX" : 1594, "maxX" : 1775, "minY" : 348, "maxY" : 565, "prop" : { "x" : 1594, "y" : 348, "width" : 181, "height" : 217 }, "textPosition" : { "x" : 1605, "y" : 519 }, "insets" : { "x" : 1604, "y" : 358, "width" : 161, "height" : 197 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 } } ], "notes" : [ ], "links" : [ { "id" : 45683, "renderableClass" : "Interaction", "position" : { "x" : 1278, "y" : 1368 }, "minX" : 1264, "maxX" : 1292, "minY" : 1362, "maxY" : 1374, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 1264, "y" : 1368 }, "to" : { "x" : 1292, "y" : 1369 } } ], "endShape" : { "a" : { "x" : 1285, "y" : 1373 }, "b" : { "x" : 1292, "y" : 1369 }, "c" : { "x" : 1285, "y" : 1365 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 1285, "y" : 1365 } }, "reactionShape" : { "a" : { "x" : 1272, "y" : 1362 }, "b" : { "x" : 1284, "y" : 1374 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1278, "y" : 1368 } }, "inputs" : [ { "id" : 45619 } ], "outputs" : [ { "id" : 45576 } ] }, { "id" : 45673, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 1506, "y" : 1288 }, "minX" : 1497, "maxX" : 1516, "minY" : 1282, "maxY" : 1294, "segments" : [ { "from" : { "x" : 1497, "y" : 1289 }, "to" : { "x" : 1516, "y" : 1287 } } ], "reactionShape" : { "a" : { "x" : 1500, "y" : 1282 }, "b" : { "x" : 1512, "y" : 1294 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1506, "y" : 1288 } }, "inputs" : [ { "id" : 45490 } ], "outputs" : [ { "id" : 45486 } ] }, { "id" : 45674, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 782, "y" : 1190 }, "minX" : 776, "maxX" : 788, "minY" : 1175, "maxY" : 1205, "segments" : [ { "from" : { "x" : 785, "y" : 1205 }, "to" : { "x" : 780, "y" : 1175 } } ], "reactionShape" : { "a" : { "x" : 776, "y" : 1184 }, "b" : { "x" : 788, "y" : 1196 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 782, "y" : 1190 } }, "inputs" : [ { "id" : 45452 } ], "outputs" : [ { "id" : 45553 } ] }, { "id" : 45691, "renderableClass" : "Interaction", "position" : { "x" : 491, "y" : 1211 }, "minX" : 480, "maxX" : 502, "minY" : 1205, "maxY" : 1217, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 480, "y" : 1207 }, "to" : { "x" : 502, "y" : 1216 } } ], "endShape" : { "a" : { "x" : 494, "y" : 1217 }, "b" : { "x" : 502, "y" : 1216 }, "c" : { "x" : 497, "y" : 1210 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 497, "y" : 1210 } }, "reactionShape" : { "a" : { "x" : 485, "y" : 1205 }, "b" : { "x" : 497, "y" : 1217 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 491, "y" : 1211 } }, "inputs" : [ { "id" : 45538 } ], "outputs" : [ { "id" : 45671 } ] }, { "id" : 45676, "renderableClass" : "Interaction", "position" : { "x" : 1421, "y" : 1351 }, "minX" : 1411, "maxX" : 1432, "minY" : 1345, "maxY" : 1357, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 1432, "y" : 1348 }, "to" : { "x" : 1411, "y" : 1355 } } ], "endShape" : { "a" : { "x" : 1416, "y" : 1349 }, "b" : { "x" : 1411, "y" : 1355 }, "c" : { "x" : 1419, "y" : 1357 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 1419, "y" : 1357 } }, "reactionShape" : { "a" : { "x" : 1415, "y" : 1345 }, "b" : { "x" : 1427, "y" : 1357 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 1421, "y" : 1351 } }, "inputs" : [ { "id" : 45474 } ], "outputs" : [ { "id" : 45576 } ] }, { "id" : 45692, "renderableClass" : "Interaction", "position" : { "x" : 571, "y" : 993 }, "minX" : 565, "maxX" : 659, "minY" : 850, "maxY" : 1212, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 659, "y" : 850 }, "to" : { "x" : 571, "y" : 993 } }, { "from" : { "x" : 571, "y" : 993 }, "to" : { "x" : 570, "y" : 1212 } } ], "endShape" : { "a" : { "x" : 566, "y" : 1205 }, "b" : { "x" : 570, "y" : 1212 }, "c" : { "x" : 574, "y" : 1205 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 574, "y" : 1205 } }, "reactionShape" : { "a" : { "x" : 565, "y" : 987 }, "b" : { "x" : 577, "y" : 999 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 571, "y" : 993 } }, "inputs" : [ { "id" : 45565 } ], "outputs" : [ { "id" : 45671 } ] }, { "id" : 45677, "renderableClass" : "Interaction", "position" : { "x" : 2209, "y" : 23 }, "minX" : 2171, "maxX" : 2248, "minY" : 17, "maxY" : 29, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 2171, "y" : 22 }, "to" : { "x" : 2248, "y" : 24 } } ], "endShape" : { "a" : { "x" : 2241, "y" : 28 }, "b" : { "x" : 2248, "y" : 24 }, "c" : { "x" : 2241, "y" : 20 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 2241, "y" : 20 } }, "reactionShape" : { "a" : { "x" : 2203, "y" : 17 }, "b" : { "x" : 2215, "y" : 29 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2209, "y" : 23 } }, "inputs" : [ { "id" : 45582 } ], "outputs" : [ { "id" : 45577 } ] } ], "shadows" : [ { "id" : 45693, "reactomeId" : 11079139, "displayName" : "Sphingolipid de novo biosynthesis", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 995, "y" : 770 }, "minX" : 456, "maxX" : 1534, "minY" : 175, "maxY" : 1365, "prop" : { "x" : 456, "y" : 175, "width" : 1078, "height" : 153 }, "points" : [ { "x" : 456, "y" : 175 }, { "x" : 1534, "y" : 175 }, { "x" : 1534, "y" : 1365 }, { "x" : 456, "y" : 1365 } ], "colour" : "#4684ee" }, { "id" : 45694, "reactomeId" : 11079143, "displayName" : "Sphingolipid catabolism", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 1286, "y" : 1032 }, "minX" : 909, "maxX" : 1663, "minY" : 664, "maxY" : 1400, "prop" : { "x" : 909, "y" : 664, "width" : 754, "height" : 736 }, "points" : [ { "x" : 909, "y" : 664 }, { "x" : 1663, "y" : 664 }, { "x" : 1663, "y" : 1400 }, { "x" : 909, "y" : 1400 } ], "colour" : "#dc3912" }, { "id" : 45695, "reactomeId" : 11079297, "displayName" : "Glycosphingolipid metabolism", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 1309, "y" : 879 }, "minX" : -10, "maxX" : 2628, "minY" : 328, "maxY" : 1430, "prop" : { "x" : 1663, "y" : 664, "width" : 965, "height" : 736 }, "points" : [ { "x" : -10, "y" : 328 }, { "x" : 2628, "y" : 328 }, { "x" : 2628, "y" : 1430 }, { "x" : -10, "y" : 1430 } ], "colour" : "#008000" } ], "minX" : 0, "maxX" : 2855, "minY" : 0, "maxY" : 1420, "disease" : false }