{
  "dbId" : 11078619,
  "stableId" : "R-SPO-163685",
  "displayName" : "Integration of energy metabolism",
  "nodes" : [ {
    "id" : 26304,
    "reactomeId" : 113592,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 2724,
      "y" : 1220
    },
    "minX" : 2640,
    "maxX" : 2745,
    "minY" : 1204,
    "maxY" : 1266,
    "prop" : {
      "x" : 2704,
      "y" : 1205,
      "width" : 40,
      "height" : 31
    },
    "textPosition" : {
      "x" : 2708,
      "y" : 1210
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2739,
          "y" : 1210
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2739,
          "y" : 1210
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 26303,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2701,
          "y" : 1230
        },
        "to" : {
          "x" : 2640,
          "y" : 1266
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 26305,
    "reactomeId" : 76194,
    "displayName" : "CoA-SH",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 2732,
      "y" : 1263
    },
    "minX" : 2640,
    "maxX" : 2764,
    "minY" : 1247,
    "maxY" : 1279,
    "prop" : {
      "x" : 2701,
      "y" : 1248,
      "width" : 62,
      "height" : 31
    },
    "textPosition" : {
      "x" : 2705,
      "y" : 1253
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2758,
          "y" : 1253
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2758,
          "y" : 1253
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 26303,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2698,
          "y" : 1264
        },
        "to" : {
          "x" : 2640,
          "y" : 1266
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 26306,
    "reactomeId" : 8876730,
    "displayName" : "LCFA(-)",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 2807,
      "y" : 1027
    },
    "minX" : 2640,
    "maxX" : 2838,
    "minY" : 1011,
    "maxY" : 1266,
    "prop" : {
      "x" : 2777,
      "y" : 1012,
      "width" : 60,
      "height" : 31
    },
    "textPosition" : {
      "x" : 2781,
      "y" : 1017
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2832,
          "y" : 1017
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2832,
          "y" : 1017
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 26303,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 2796,
          "y" : 1046
        },
        "to" : {
          "x" : 2640,
          "y" : 1266
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 26307,
    "reactomeId" : 164991,
    "displayName" : "LCFA-CoA",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 2445,
      "y" : 1265
    },
    "minX" : 2408,
    "maxX" : 2541,
    "minY" : 1249,
    "maxY" : 1281,
    "prop" : {
      "x" : 2408,
      "y" : 1250,
      "width" : 75,
      "height" : 31
    },
    "textPosition" : {
      "x" : 2413,
      "y" : 1255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2478,
          "y" : 1255
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2478,
          "y" : 1255
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 26303,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 2486,
          "y" : 1265
        },
        "to" : {
          "x" : 2541,
          "y" : 1266
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 2493,
          "y" : 1261
        },
        "b" : {
          "x" : 2486,
          "y" : 1265
        },
        "c" : {
          "x" : 2493,
          "y" : 1269
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 2493,
          "y" : 1269
        }
      }
    } ]
  }, {
    "id" : 26308,
    "reactomeId" : 76577,
    "displayName" : "AMP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 2479,
      "y" : 1210
    },
    "minX" : 2458,
    "maxX" : 2541,
    "minY" : 1194,
    "maxY" : 1266,
    "prop" : {
      "x" : 2458,
      "y" : 1195,
      "width" : 42,
      "height" : 31
    },
    "textPosition" : {
      "x" : 2462,
      "y" : 1200
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2495,
          "y" : 1200
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2495,
          "y" : 1200
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 26303,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 2496,
          "y" : 1229
        },
        "to" : {
          "x" : 2541,
          "y" : 1266
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 2504,
          "y" : 1230
        },
        "b" : {
          "x" : 2496,
          "y" : 1229
        },
        "c" : {
          "x" : 2499,
          "y" : 1236
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 2499,
          "y" : 1236
        }
      }
    } ]
  }, {
    "id" : 26309,
    "reactomeId" : 111294,
    "displayName" : "PPi",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 2541,
      "y" : 1202
    },
    "minX" : 2524,
    "maxX" : 2559,
    "minY" : 1186,
    "maxY" : 1266,
    "prop" : {
      "x" : 2524,
      "y" : 1187,
      "width" : 34,
      "height" : 31
    },
    "textPosition" : {
      "x" : 2527,
      "y" : 1192
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 2553,
          "y" : 1192
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2553,
          "y" : 1192
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 26303,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 2541,
          "y" : 1221
        },
        "to" : {
          "x" : 2541,
          "y" : 1266
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 2545,
          "y" : 1228
        },
        "b" : {
          "x" : 2541,
          "y" : 1221
        },
        "c" : {
          "x" : 2537,
          "y" : 1228
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 2537,
          "y" : 1228
        }
      }
    } ]
  }, {
    "id" : 26310,
    "reactomeId" : 11060588,
    "displayName" : "ACSL3,4",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 2606,
      "y" : 1318
    },
    "minX" : 2578,
    "maxX" : 2635,
    "minY" : 1274,
    "maxY" : 1330,
    "prop" : {
      "x" : 2578,
      "y" : 1307,
      "width" : 57,
      "height" : 23
    },
    "textPosition" : {
      "x" : 2581,
      "y" : 1301
    },
    "connectors" : [ {
      "edgeId" : 26303,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 2605,
          "y" : 1301
        },
        "to" : {
          "x" : 2604,
          "y" : 1282
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 2604,
          "y" : 1278
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 2604,
          "y" : 1278
        }
      }
    } ]
  }, {
    "id" : 26286,
    "reactomeId" : 11056062,
    "displayName" : "Homologues of PRKCA",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1785,
      "y" : 1514
    },
    "minX" : 1752,
    "maxX" : 1809,
    "minY" : 1503,
    "maxY" : 1568,
    "prop" : {
      "x" : 1761,
      "y" : 1503,
      "width" : 48,
      "height" : 23
    },
    "textPosition" : {
      "x" : 1760,
      "y" : 1483
    },
    "connectors" : [ {
      "edgeId" : 26285,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1786,
          "y" : 1529
        },
        "to" : {
          "x" : 1791,
          "y" : 1568
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 26285,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 1777,
          "y" : 1529
        },
        "to" : {
          "x" : 1758,
          "y" : 1554
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1756,
          "y" : 1557
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1756,
          "y" : 1557
        }
      }
    } ]
  }, {
    "id" : 26287,
    "reactomeId" : 114519,
    "displayName" : "DAG",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1834,
      "y" : 1589
    },
    "minX" : 1791,
    "maxX" : 1857,
    "minY" : 1568,
    "maxY" : 1605,
    "prop" : {
      "x" : 1813,
      "y" : 1574,
      "width" : 43,
      "height" : 31
    },
    "textPosition" : {
      "x" : 1817,
      "y" : 1579
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1851,
          "y" : 1579
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1851,
          "y" : 1579
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 26285,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1810,
          "y" : 1578
        },
        "to" : {
          "x" : 1791,
          "y" : 1568
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 26288,
    "reactomeId" : 11059905,
    "displayName" : "Protein Kinase C, alpha type: DAG",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1647,
      "y" : 1592
    },
    "minX" : 1592,
    "maxX" : 1709,
    "minY" : 1568,
    "maxY" : 1611,
    "prop" : {
      "x" : 1592,
      "y" : 1574,
      "width" : 111,
      "height" : 37
    },
    "textPosition" : {
      "x" : 1596,
      "y" : 1562
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1703,
          "y" : 1574
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1703,
          "y" : 1574
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 26285,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 26290,
    "reactomeId" : 11055796,
    "displayName" : "PKA tetramer:4xcAMP",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 717,
      "y" : 337
    },
    "minX" : 672,
    "maxX" : 798,
    "minY" : 313,
    "maxY" : 364,
    "prop" : {
      "x" : 672,
      "y" : 319,
      "width" : 90,
      "height" : 37
    },
    "textPosition" : {
      "x" : 683,
      "y" : 307
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 762,
          "y" : 319
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 762,
          "y" : 319
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 26289,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 26289,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 765,
          "y" : 352
        },
        "to" : {
          "x" : 794,
          "y" : 364
        }
      }, {
        "from" : {
          "x" : 794,
          "y" : 364
        },
        "to" : {
          "x" : 794,
          "y" : 354
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 794,
          "y" : 350
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 794,
          "y" : 350
        }
      }
    } ]
  }, {
    "id" : 26291,
    "reactomeId" : 11055792,
    "displayName" : "PRKACA",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 892,
      "y" : 393
    },
    "minX" : 822,
    "maxX" : 962,
    "minY" : 337,
    "maxY" : 405,
    "prop" : {
      "x" : 828,
      "y" : 382,
      "width" : 128,
      "height" : 23
    },
    "textPosition" : {
      "x" : 864,
      "y" : 383
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 956,
          "y" : 382
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 956,
          "y" : 382
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 26289,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 877,
          "y" : 376
        },
        "to" : {
          "x" : 822,
          "y" : 337
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 843,
            "y" : 350
          },
          "b" : {
            "x" : 855,
            "y" : 362
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 849,
            "y" : 356
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 869,
          "y" : 375
        },
        "b" : {
          "x" : 877,
          "y" : 376
        },
        "c" : {
          "x" : 874,
          "y" : 369
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 874,
          "y" : 369
        }
      }
    } ]
  }, {
    "id" : 26292,
    "reactomeId" : 11055798,
    "displayName" : "cAMP:PKA regulatory subunit",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 888,
      "y" : 287
    },
    "minX" : 822,
    "maxX" : 961,
    "minY" : 263,
    "maxY" : 337,
    "prop" : {
      "x" : 822,
      "y" : 269,
      "width" : 133,
      "height" : 37
    },
    "textPosition" : {
      "x" : 827,
      "y" : 271
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 955,
          "y" : 269
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 955,
          "y" : 269
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 26289,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 863,
          "y" : 309
        },
        "to" : {
          "x" : 822,
          "y" : 337
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 860,
          "y" : 316
        },
        "b" : {
          "x" : 863,
          "y" : 309
        },
        "c" : {
          "x" : 855,
          "y" : 310
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 855,
          "y" : 310
        }
      }
    } ]
  }, {
    "id" : 26294,
    "reactomeId" : 29512,
    "displayName" : "Fru(6)P",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 270,
      "y" : 850
    },
    "minX" : 241,
    "maxX" : 341,
    "minY" : 834,
    "maxY" : 882,
    "prop" : {
      "x" : 241,
      "y" : 835,
      "width" : 58,
      "height" : 31
    },
    "textPosition" : {
      "x" : 243,
      "y" : 840
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 294,
          "y" : 840
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 294,
          "y" : 840
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 26293,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 302,
          "y" : 863
        },
        "to" : {
          "x" : 341,
          "y" : 882
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 26295,
    "reactomeId" : 29878,
    "displayName" : "E4P",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 269,
      "y" : 906
    },
    "minX" : 250,
    "maxX" : 341,
    "minY" : 882,
    "maxY" : 922,
    "prop" : {
      "x" : 250,
      "y" : 891,
      "width" : 39,
      "height" : 31
    },
    "textPosition" : {
      "x" : 253,
      "y" : 896
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 284,
          "y" : 896
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 284,
          "y" : 896
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 26293,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 292,
          "y" : 899
        },
        "to" : {
          "x" : 341,
          "y" : 882
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 26296,
    "reactomeId" : 29882,
    "displayName" : "SH7P",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 460,
      "y" : 910
    },
    "minX" : 413,
    "maxX" : 485,
    "minY" : 882,
    "maxY" : 926,
    "prop" : {
      "x" : 437,
      "y" : 895,
      "width" : 47,
      "height" : 31
    },
    "textPosition" : {
      "x" : 440,
      "y" : 900
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 479,
          "y" : 900
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 479,
          "y" : 900
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 26293,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 434,
          "y" : 896
        },
        "to" : {
          "x" : 413,
          "y" : 882
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 426,
          "y" : 895
        },
        "b" : {
          "x" : 434,
          "y" : 896
        },
        "c" : {
          "x" : 430,
          "y" : 889
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 430,
          "y" : 889
        }
      }
    } ]
  }, {
    "id" : 26297,
    "reactomeId" : 29578,
    "displayName" : "GA3P",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 463,
      "y" : 852
    },
    "minX" : 413,
    "maxX" : 489,
    "minY" : 836,
    "maxY" : 882,
    "prop" : {
      "x" : 439,
      "y" : 837,
      "width" : 49,
      "height" : 31
    },
    "textPosition" : {
      "x" : 443,
      "y" : 842
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 483,
          "y" : 842
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 483,
          "y" : 842
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 26293,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 436,
          "y" : 866
        },
        "to" : {
          "x" : 413,
          "y" : 882
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 433,
          "y" : 873
        },
        "b" : {
          "x" : 436,
          "y" : 866
        },
        "c" : {
          "x" : 428,
          "y" : 867
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 428,
          "y" : 867
        }
      }
    } ]
  }, {
    "id" : 26298,
    "reactomeId" : 11052696,
    "displayName" : "TALDO1 dimer",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 380,
      "y" : 953
    },
    "minX" : 333,
    "maxX" : 434,
    "minY" : 890,
    "maxY" : 965,
    "prop" : {
      "x" : 333,
      "y" : 942,
      "width" : 95,
      "height" : 23
    },
    "textPosition" : {
      "x" : 333,
      "y" : 944
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 428,
          "y" : 942
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 428,
          "y" : 942
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 26293,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 380,
          "y" : 939
        },
        "to" : {
          "x" : 380,
          "y" : 898
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 380,
          "y" : 894
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 380,
          "y" : 894
        }
      }
    } ]
  }, {
    "id" : 26300,
    "reactomeId" : 164121,
    "displayName" : "AMP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1778,
      "y" : 331
    },
    "minX" : 1757,
    "maxX" : 1800,
    "minY" : 315,
    "maxY" : 368,
    "prop" : {
      "x" : 1757,
      "y" : 316,
      "width" : 42,
      "height" : 31
    },
    "textPosition" : {
      "x" : 1761,
      "y" : 321
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1794,
          "y" : 321
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1794,
          "y" : 321
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 26299,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1771,
          "y" : 350
        },
        "to" : {
          "x" : 1762,
          "y" : 368
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 26301,
    "reactomeId" : 11056545,
    "displayName" : "AMPK heterotrimer (inactive)",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1829,
      "y" : 390
    },
    "minX" : 1762,
    "maxX" : 1896,
    "minY" : 366,
    "maxY" : 409,
    "prop" : {
      "x" : 1768,
      "y" : 372,
      "width" : 122,
      "height" : 37
    },
    "textPosition" : {
      "x" : 1783,
      "y" : 360
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1890,
          "y" : 372
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1890,
          "y" : 372
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 26299,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1772,
          "y" : 369
        },
        "to" : {
          "x" : 1762,
          "y" : 368
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 26302,
    "reactomeId" : 11056549,
    "displayName" : "AMPK heterotrimer:AMP",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1661,
      "y" : 368
    },
    "minX" : 1600,
    "maxX" : 1728,
    "minY" : 344,
    "maxY" : 387,
    "prop" : {
      "x" : 1600,
      "y" : 350,
      "width" : 122,
      "height" : 37
    },
    "textPosition" : {
      "x" : 1602,
      "y" : 352
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1722,
          "y" : 350
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1722,
          "y" : 350
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 26299,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  } ],
  "edges" : [ {
    "id" : 26289,
    "reactomeId" : 11055801,
    "displayName" : "cAMP induces dissociation of inactive PKA tetramers",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 794,
      "y" : 338
    },
    "minX" : 765,
    "maxX" : 822,
    "minY" : 332,
    "maxY" : 344,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 765,
        "y" : 337
      },
      "to" : {
        "x" : 794,
        "y" : 338
      }
    }, {
      "from" : {
        "x" : 794,
        "y" : 338
      },
      "to" : {
        "x" : 822,
        "y" : 337
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 788,
        "y" : 332
      },
      "b" : {
        "x" : 800,
        "y" : 344
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 794,
        "y" : 338
      }
    },
    "inputs" : [ {
      "id" : 26290
    } ],
    "outputs" : [ {
      "id" : 26291,
      "points" : [ {
        "x" : 877,
        "y" : 376
      } ],
      "stoichiometry" : 2
    }, {
      "id" : 26292,
      "points" : [ {
        "x" : 863,
        "y" : 309
      } ]
    } ],
    "catalysts" : [ {
      "id" : 26290,
      "points" : [ {
        "x" : 765,
        "y" : 352
      }, {
        "x" : 794,
        "y" : 364
      } ]
    } ]
  }, {
    "id" : 26293,
    "reactomeId" : 11056553,
    "displayName" : "D-fructose 6-phosphate + D-erythrose 4-phosphate  <=>  sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 380,
      "y" : 882
    },
    "minX" : 341,
    "maxX" : 413,
    "minY" : 876,
    "maxY" : 888,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 341,
        "y" : 882
      },
      "to" : {
        "x" : 380,
        "y" : 882
      }
    }, {
      "from" : {
        "x" : 380,
        "y" : 882
      },
      "to" : {
        "x" : 413,
        "y" : 882
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 374,
        "y" : 876
      },
      "b" : {
        "x" : 386,
        "y" : 888
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 380,
        "y" : 882
      }
    },
    "inputs" : [ {
      "id" : 26294,
      "points" : [ {
        "x" : 302,
        "y" : 863
      } ]
    }, {
      "id" : 26295,
      "points" : [ {
        "x" : 292,
        "y" : 899
      } ]
    } ],
    "outputs" : [ {
      "id" : 26296,
      "points" : [ {
        "x" : 434,
        "y" : 896
      } ]
    }, {
      "id" : 26297,
      "points" : [ {
        "x" : 436,
        "y" : 866
      } ]
    } ],
    "catalysts" : [ {
      "id" : 26298,
      "points" : [ {
        "x" : 380,
        "y" : 939
      } ]
    } ]
  }, {
    "id" : 26299,
    "reactomeId" : 11056551,
    "displayName" : "AMP binds to gamma subunit of AMP kinase heterotrimer",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1762,
      "y" : 367
    },
    "minX" : 1725,
    "maxX" : 1768,
    "minY" : 361,
    "maxY" : 373,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 1762,
        "y" : 368
      },
      "to" : {
        "x" : 1762,
        "y" : 367
      }
    }, {
      "from" : {
        "x" : 1762,
        "y" : 367
      },
      "to" : {
        "x" : 1725,
        "y" : 367
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1732,
        "y" : 363
      },
      "b" : {
        "x" : 1725,
        "y" : 367
      },
      "c" : {
        "x" : 1732,
        "y" : 371
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1732,
        "y" : 371
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1762,
        "y" : 367
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1762,
        "y" : 367
      }
    },
    "inputs" : [ {
      "id" : 26300,
      "points" : [ {
        "x" : 1771,
        "y" : 350
      } ]
    }, {
      "id" : 26301,
      "points" : [ {
        "x" : 1772,
        "y" : 369
      } ]
    } ],
    "outputs" : [ {
      "id" : 26302
    } ]
  }, {
    "id" : 26285,
    "reactomeId" : 11059908,
    "displayName" : "Diacylgycerol activates Protein kinase C, alpha type",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1749,
      "y" : 1567
    },
    "minX" : 1706,
    "maxX" : 1791,
    "minY" : 1561,
    "maxY" : 1578,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1791,
        "y" : 1568
      },
      "to" : {
        "x" : 1749,
        "y" : 1567
      }
    }, {
      "from" : {
        "x" : 1749,
        "y" : 1567
      },
      "to" : {
        "x" : 1706,
        "y" : 1578
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1712,
        "y" : 1572
      },
      "b" : {
        "x" : 1706,
        "y" : 1578
      },
      "c" : {
        "x" : 1714,
        "y" : 1580
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1714,
        "y" : 1580
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 1743,
        "y" : 1561
      },
      "b" : {
        "x" : 1755,
        "y" : 1573
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1749,
        "y" : 1567
      }
    },
    "inputs" : [ {
      "id" : 26286,
      "points" : [ {
        "x" : 1786,
        "y" : 1529
      } ]
    }, {
      "id" : 26287,
      "points" : [ {
        "x" : 1810,
        "y" : 1578
      } ]
    } ],
    "outputs" : [ {
      "id" : 26288
    } ],
    "catalysts" : [ {
      "id" : 26286,
      "points" : [ {
        "x" : 1777,
        "y" : 1529
      } ]
    } ]
  }, {
    "id" : 26303,
    "reactomeId" : 11060591,
    "displayName" : "ACSL3,4 ligates coenzyme A (CoA-SH) to a long chain fatty acid yielding fatty acyl-coenzyme A",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 2604,
      "y" : 1266
    },
    "minX" : 2541,
    "maxX" : 2640,
    "minY" : 1260,
    "maxY" : 1272,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 2640,
        "y" : 1266
      },
      "to" : {
        "x" : 2604,
        "y" : 1266
      }
    }, {
      "from" : {
        "x" : 2604,
        "y" : 1266
      },
      "to" : {
        "x" : 2541,
        "y" : 1266
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 2598,
        "y" : 1260
      },
      "b" : {
        "x" : 2610,
        "y" : 1272
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 2604,
        "y" : 1266
      }
    },
    "inputs" : [ {
      "id" : 26304,
      "points" : [ {
        "x" : 2701,
        "y" : 1230
      } ]
    }, {
      "id" : 26305,
      "points" : [ {
        "x" : 2698,
        "y" : 1264
      } ]
    }, {
      "id" : 26306,
      "points" : [ {
        "x" : 2796,
        "y" : 1046
      } ]
    } ],
    "outputs" : [ {
      "id" : 26307,
      "points" : [ {
        "x" : 2486,
        "y" : 1265
      } ]
    }, {
      "id" : 26308,
      "points" : [ {
        "x" : 2496,
        "y" : 1229
      } ]
    }, {
      "id" : 26309,
      "points" : [ {
        "x" : 2541,
        "y" : 1221
      } ]
    } ],
    "catalysts" : [ {
      "id" : 26310,
      "points" : [ {
        "x" : 2605,
        "y" : 1301
      } ]
    } ]
  } ],
  "compartments" : [ {
    "id" : 26342,
    "reactomeId" : 216798,
    "displayName" : "secretory granule",
    "schemaClass" : "GO_CellularComponent",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 2698,
      "y" : 619
    },
    "minX" : 2573,
    "maxX" : 2823,
    "minY" : 466,
    "maxY" : 773,
    "prop" : {
      "x" : 2573,
      "y" : 466,
      "width" : 250,
      "height" : 307
    },
    "textPosition" : {
      "x" : 2584,
      "y" : 724
    },
    "insets" : {
      "x" : 2583,
      "y" : 476,
      "width" : 230,
      "height" : 287
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    }
  }, {
    "id" : 26343,
    "reactomeId" : 17957,
    "displayName" : "endoplasmic reticulum lumen",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 2244,
      "y" : 1076
    },
    "minX" : 2105,
    "maxX" : 2383,
    "minY" : 930,
    "maxY" : 1223,
    "prop" : {
      "x" : 2105,
      "y" : 930,
      "width" : 278,
      "height" : 293
    },
    "textPosition" : {
      "x" : 2120,
      "y" : 1101
    },
    "insets" : {
      "x" : 2115,
      "y" : 940,
      "width" : 258,
      "height" : 273
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    }
  }, {
    "id" : 26312,
    "reactomeId" : 7660,
    "displayName" : "nucleoplasm",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 1574,
      "y" : 576
    },
    "minX" : 1065,
    "maxX" : 2084,
    "minY" : 180,
    "maxY" : 973,
    "prop" : {
      "x" : 1065,
      "y" : 180,
      "width" : 1019,
      "height" : 793
    },
    "textPosition" : {
      "x" : 1146,
      "y" : 533
    },
    "insets" : {
      "x" : 1075,
      "y" : 190,
      "width" : 999,
      "height" : 773
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 26301, 26302, 26300, 26299 ]
  }, {
    "id" : 26313,
    "reactomeId" : 70101,
    "displayName" : "cytosol",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 1456,
      "y" : 797
    },
    "minX" : 0,
    "maxX" : 2913,
    "minY" : 0,
    "maxY" : 1595,
    "prop" : {
      "x" : 0,
      "y" : 0,
      "width" : 2913,
      "height" : 1595
    },
    "textPosition" : {
      "x" : 232,
      "y" : 1317
    },
    "insets" : {
      "x" : 10,
      "y" : 10,
      "width" : 2893,
      "height" : 1575
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 26312, 26291, 26287, 26285, 26286, 26294, 26295, 26296, 26297, 26342, 26343, 26289, 26293, 26381, 26298, 26290, 26292, 26288, 26365, 26303, 26305, 26308, 26382, 26304, 26306, 26307, 26309 ]
  }, {
    "id" : 26365,
    "reactomeId" : 17906,
    "displayName" : "mitochondrial outer membrane",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 2547,
      "y" : 1338
    },
    "minX" : 2375,
    "maxX" : 2719,
    "minY" : 1299,
    "maxY" : 1378,
    "prop" : {
      "x" : 2375,
      "y" : 1299,
      "width" : 344,
      "height" : 79
    },
    "textPosition" : {
      "x" : 2452,
      "y" : 1331
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 26310 ]
  } ],
  "notes" : [ ],
  "links" : [ ],
  "shadows" : [ {
    "id" : 26368,
    "reactomeId" : 11078747,
    "displayName" : "Insulin effects increased synthesis of Xylulose-5-Phosphate",
    "schemaClass" : "Pathway",
    "renderableClass" : "Shadow",
    "position" : {
      "x" : 364,
      "y" : 900
    },
    "minX" : 231,
    "maxX" : 498,
    "minY" : 825,
    "maxY" : 975,
    "prop" : {
      "x" : 231,
      "y" : 825,
      "width" : 267,
      "height" : 150
    },
    "points" : [ {
      "x" : 231,
      "y" : 825
    }, {
      "x" : 498,
      "y" : 825
    }, {
      "x" : 498,
      "y" : 975
    }, {
      "x" : 231,
      "y" : 975
    } ],
    "colour" : "#008000"
  }, {
    "id" : 26369,
    "reactomeId" : 11079091,
    "displayName" : "Regulation of insulin secretion",
    "schemaClass" : "Pathway",
    "renderableClass" : "Shadow",
    "position" : {
      "x" : 2214,
      "y" : 1311
    },
    "minX" : 1582,
    "maxX" : 2847,
    "minY" : 1002,
    "maxY" : 1621,
    "prop" : {
      "x" : 1582,
      "y" : 1002,
      "width" : 1265,
      "height" : 619
    },
    "points" : [ {
      "x" : 1582,
      "y" : 1002
    }, {
      "x" : 2847,
      "y" : 1002
    }, {
      "x" : 2847,
      "y" : 1621
    }, {
      "x" : 1582,
      "y" : 1621
    } ],
    "colour" : "#666666"
  }, {
    "id" : 26366,
    "reactomeId" : 11078617,
    "displayName" : "Glucagon signaling in metabolic regulation",
    "schemaClass" : "Pathway",
    "renderableClass" : "Shadow",
    "position" : {
      "x" : 814,
      "y" : 337
    },
    "minX" : 662,
    "maxX" : 966,
    "minY" : 259,
    "maxY" : 415,
    "prop" : {
      "x" : 662,
      "y" : 259,
      "width" : 304,
      "height" : 156
    },
    "points" : [ {
      "x" : 662,
      "y" : 259
    }, {
      "x" : 966,
      "y" : 259
    }, {
      "x" : 966,
      "y" : 415
    }, {
      "x" : 662,
      "y" : 415
    } ],
    "colour" : "#4684ee"
  }, {
    "id" : 26367,
    "reactomeId" : 11078745,
    "displayName" : "AMPK inhibits chREBP transcriptional activation activity",
    "schemaClass" : "Pathway",
    "renderableClass" : "Shadow",
    "position" : {
      "x" : 1745,
      "y" : 362
    },
    "minX" : 1590,
    "maxX" : 1900,
    "minY" : 306,
    "maxY" : 419,
    "prop" : {
      "x" : 1590,
      "y" : 306,
      "width" : 310,
      "height" : 113
    },
    "points" : [ {
      "x" : 1590,
      "y" : 306
    }, {
      "x" : 1900,
      "y" : 306
    }, {
      "x" : 1900,
      "y" : 419
    }, {
      "x" : 1590,
      "y" : 419
    } ],
    "colour" : "#dc3912"
  } ],
  "minX" : 0,
  "maxX" : 2913,
  "minY" : 0,
  "maxY" : 1611,
  "disease" : false
}