{ "dbId" : 11107826, "stableId" : "R-SCE-3371556", "displayName" : "Cellular response to heat stress", "nodes" : [ { "id" : 22823, "reactomeId" : 11094143, "displayName" : "HSF1:HSP90:PTGES3", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 300, "y" : 184 }, "minX" : 236, "maxX" : 371, "minY" : 160, "maxY" : 202, "prop" : { "x" : 236, "y" : 166, "width" : 129, "height" : 36 }, "textPosition" : { "x" : 256, "y" : 167 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 365, "y" : 166 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 365, "y" : 166 } } }, "connectors" : [ { "edgeId" : 22822, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 22824, "reactomeId" : 11094000, "displayName" : "HSF1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 638, "y" : 224 }, "minX" : 434, "maxX" : 785, "minY" : 190, "maxY" : 286, "prop" : { "x" : 618, "y" : 213, "width" : 41, "height" : 22 }, "textPosition" : { "x" : 618, "y" : 213 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 659, "y" : 213 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 659, "y" : 213 } } }, "connectors" : [ { "edgeId" : 22822, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 615, "y" : 219 }, "to" : { "x" : 470, "y" : 190 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 607, "y" : 222 }, "b" : { "x" : 615, "y" : 219 }, "c" : { "x" : 609, "y" : 214 }, "type" : "ARROW", "centre" : { "x" : 609, "y" : 214 } } }, { "edgeId" : 22827, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 3, "shape" : { "a" : { "x" : 632, "y" : 250 }, "b" : { "x" : 644, "y" : 262 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 638, "y" : 256 } } } }, { "edgeId" : 22869, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 632, "y" : 238 }, "to" : { "x" : 608, "y" : 281 } }, { "from" : { "x" : 608, "y" : 281 }, "to" : { "x" : 434, "y" : 286 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 632, "y" : 246 }, "b" : { "x" : 632, "y" : 238 }, "c" : { "x" : 625, "y" : 242 }, "type" : "ARROW", "centre" : { "x" : 625, "y" : 242 } } }, { "edgeId" : 22838, "type" : "INPUT", "segments" : [ { "from" : { "x" : 662, "y" : 223 }, "to" : { "x" : 785, "y" : 217 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 22825, "reactomeId" : 11087310, "displayName" : "SBA1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 470, "y" : 239 }, "minX" : 434, "maxX" : 505, "minY" : 190, "maxY" : 286, "prop" : { "x" : 442, "y" : 228, "width" : 57, "height" : 22 }, "textPosition" : { "x" : 450, "y" : 228 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 499, "y" : 228 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 499, "y" : 228 } } }, "connectors" : [ { "edgeId" : 22822, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 470, "y" : 225 }, "to" : { "x" : 470, "y" : 190 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 464, "y" : 201 }, "b" : { "x" : 476, "y" : 213 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 470, "y" : 207 } } }, "endShape" : { "a" : { "x" : 466, "y" : 218 }, "b" : { "x" : 470, "y" : 225 }, "c" : { "x" : 474, "y" : 218 }, "type" : "ARROW", "centre" : { "x" : 474, "y" : 218 } } }, { "edgeId" : 22869, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 461, "y" : 253 }, "to" : { "x" : 434, "y" : 286 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 441, "y" : 263 }, "b" : { "x" : 453, "y" : 275 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 447, "y" : 269 } } }, "endShape" : { "a" : { "x" : 460, "y" : 261 }, "b" : { "x" : 461, "y" : 253 }, "c" : { "x" : 454, "y" : 256 }, "type" : "ARROW", "centre" : { "x" : 454, "y" : 256 } } } ] }, { "id" : 22826, "reactomeId" : 11094121, "displayName" : "HSP90:HSP90", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 559, "y" : 247 }, "minX" : 434, "maxX" : 607, "minY" : 190, "maxY" : 286, "prop" : { "x" : 512, "y" : 236, "width" : 95, "height" : 22 }, "textPosition" : { "x" : 512, "y" : 236 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "fgColor" : { "r" : 0, "g" : 0, "b" : 0 }, "connectors" : [ { "edgeId" : 22822, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 541, "y" : 230 }, "to" : { "x" : 470, "y" : 190 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 533, "y" : 230 }, "b" : { "x" : 541, "y" : 230 }, "c" : { "x" : 537, "y" : 223 }, "type" : "ARROW", "centre" : { "x" : 537, "y" : 223 } } }, { "edgeId" : 22869, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 523, "y" : 264 }, "to" : { "x" : 434, "y" : 286 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 517, "y" : 270 }, "b" : { "x" : 523, "y" : 264 }, "c" : { "x" : 515, "y" : 262 }, "type" : "ARROW", "centre" : { "x" : 515, "y" : 262 } } } ] }, { "id" : 22828, "reactomeId" : 11094135, "displayName" : "HSF1 trimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 676, "y" : 330 }, "minX" : 635, "maxX" : 723, "minY" : 313, "maxY" : 341, "prop" : { "x" : 635, "y" : 319, "width" : 82, "height" : 22 }, "textPosition" : { "x" : 635, "y" : 320 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 717, "y" : 319 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 717, "y" : 319 } } }, "connectors" : [ { "edgeId" : 22827, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 22830, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 22829, "reactomeId" : 11084671, "displayName" : "EEF1A1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 695, "y" : 275 }, "minX" : 647, "maxX" : 729, "minY" : 258, "maxY" : 286, "prop" : { "x" : 667, "y" : 264, "width" : 56, "height" : 22 }, "textPosition" : { "x" : 667, "y" : 264 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 723, "y" : 264 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 723, "y" : 264 } } }, "connectors" : [ { "edgeId" : 22827, "type" : "ACTIVATOR", "segments" : [ { "from" : { "x" : 664, "y" : 275 }, "to" : { "x" : 647, "y" : 275 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 654, "y" : 271 }, "b" : { "x" : 647, "y" : 275 }, "c" : { "x" : 654, "y" : 279 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 654, "y" : 279 } } } ] }, { "id" : 22831, "reactomeId" : 11094103, "displayName" : "HSF1 trimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 833, "y" : 535 }, "minX" : 792, "maxX" : 934, "minY" : 499, "maxY" : 546, "prop" : { "x" : 792, "y" : 524, "width" : 82, "height" : 22 }, "textPosition" : { "x" : 792, "y" : 525 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 874, "y" : 524 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 874, "y" : 524 } } }, "connectors" : [ { "edgeId" : 22850, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 22830, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 22833, "type" : "INPUT", "segments" : [ { "from" : { "x" : 863, "y" : 521 }, "to" : { "x" : 934, "y" : 499 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 22832, "reactomeId" : 11083397, "displayName" : "YWHAE dimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 952, "y" : 347 }, "minX" : 833, "maxX" : 1004, "minY" : 318, "maxY" : 437, "prop" : { "x" : 907, "y" : 336, "width" : 91, "height" : 22 }, "textPosition" : { "x" : 907, "y" : 337 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 998, "y" : 336 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 998, "y" : 336 } } }, "connectors" : [ { "edgeId" : 22830, "type" : "INHIBITOR", "segments" : [ { "from" : { "x" : 936, "y" : 361 }, "to" : { "x" : 853, "y" : 419 } }, { "from" : { "x" : 853, "y" : 419 }, "to" : { "x" : 836, "y" : 434 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 833, "y" : 431 }, "b" : { "x" : 839, "y" : 437 }, "c" : { "x" : 836, "y" : 434 }, "type" : "STOP", "centre" : { "x" : 836, "y" : 434 } } }, { "edgeId" : 22843, "type" : "INPUT", "segments" : [ { "from" : { "x" : 964, "y" : 333 }, "to" : { "x" : 985, "y" : 318 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 22834, "reactomeId" : 29358, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 869, "y" : 471 }, "minX" : 849, "maxX" : 934, "minY" : 455, "maxY" : 499, "prop" : { "x" : 849, "y" : 456, "width" : 40, "height" : 30 }, "textPosition" : { "x" : 853, "y" : 460 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 884, "y" : 461 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 884, "y" : 461 } } }, "connectors" : [ { "edgeId" : 22833, "type" : "INPUT", "segments" : [ { "from" : { "x" : 892, "y" : 479 }, "to" : { "x" : 934, "y" : 499 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 22835, "reactomeId" : 11094633, "displayName" : "p-S326-HSF1 trimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1210, "y" : 554 }, "minX" : 1001, "maxX" : 1301, "minY" : 498, "maxY" : 661, "prop" : { "x" : 1146, "y" : 543, "width" : 129, "height" : 22 }, "textPosition" : { "x" : 1146, "y" : 544 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1275, "y" : 543 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1275, "y" : 543 } } }, "connectors" : [ { "edgeId" : 22833, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1168, "y" : 540 }, "to" : { "x" : 1001, "y" : 498 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1160, "y" : 542 }, "b" : { "x" : 1168, "y" : 540 }, "c" : { "x" : 1162, "y" : 534 }, "type" : "ARROW", "centre" : { "x" : 1162, "y" : 534 } } }, { "edgeId" : 22866, "type" : "ACTIVATOR", "segments" : [ { "from" : { "x" : 1278, "y" : 556 }, "to" : { "x" : 1300, "y" : 558 } }, { "from" : { "x" : 1300, "y" : 558 }, "to" : { "x" : 1301, "y" : 602 } }, { "from" : { "x" : 1301, "y" : 602 }, "to" : { "x" : 1188, "y" : 661 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1192, "y" : 654 }, "b" : { "x" : 1188, "y" : 661 }, "c" : { "x" : 1196, "y" : 661 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 1196, "y" : 661 } } } ] }, { "id" : 22836, "reactomeId" : 113582, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1106, "y" : 472 }, "minX" : 1001, "maxX" : 1128, "minY" : 456, "maxY" : 498, "prop" : { "x" : 1086, "y" : 457, "width" : 41, "height" : 30 }, "textPosition" : { "x" : 1090, "y" : 461 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1122, "y" : 462 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1122, "y" : 462 } } }, "connectors" : [ { "edgeId" : 22833, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 1083, "y" : 477 }, "to" : { "x" : 1001, "y" : 498 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1077, "y" : 483 }, "b" : { "x" : 1083, "y" : 477 }, "c" : { "x" : 1075, "y" : 475 }, "type" : "ARROW", "centre" : { "x" : 1075, "y" : 475 } } } ] }, { "id" : 22837, "reactomeId" : 11094660, "displayName" : "mTORC1 dimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 966, "y" : 460 }, "minX" : 917, "maxX" : 1022, "minY" : 443, "maxY" : 490, "prop" : { "x" : 917, "y" : 449, "width" : 99, "height" : 22 }, "textPosition" : { "x" : 917, "y" : 450 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1016, "y" : 449 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1016, "y" : 449 } } }, "connectors" : [ { "edgeId" : 22833, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 966, "y" : 474 }, "to" : { "x" : 966, "y" : 482 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 967, "y" : 486 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 967, "y" : 486 } } } ] }, { "id" : 22839, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 723, "y" : 152 }, "minX" : 703, "maxX" : 785, "minY" : 136, "maxY" : 217, "prop" : { "x" : 703, "y" : 137, "width" : 40, "height" : 30 }, "textPosition" : { "x" : 707, "y" : 141 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 738, "y" : 142 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 738, "y" : 142 } } }, "connectors" : [ { "edgeId" : 22838, "type" : "INPUT", "segments" : [ { "from" : { "x" : 737, "y" : 170 }, "to" : { "x" : 785, "y" : 217 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 22840, "reactomeId" : 11094003, "displayName" : "phospho-HSF1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 960, "y" : 246 }, "minX" : 830, "maxX" : 1011, "minY" : 217, "maxY" : 257, "prop" : { "x" : 915, "y" : 235, "width" : 90, "height" : 22 }, "textPosition" : { "x" : 926, "y" : 229 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1005, "y" : 235 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1005, "y" : 235 } } }, "connectors" : [ { "edgeId" : 22838, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 912, "y" : 235 }, "to" : { "x" : 830, "y" : 217 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 904, "y" : 237 }, "b" : { "x" : 912, "y" : 235 }, "c" : { "x" : 906, "y" : 230 }, "type" : "ARROW", "centre" : { "x" : 906, "y" : 230 } } } ] }, { "id" : 22841, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 916, "y" : 145 }, "minX" : 830, "maxX" : 938, "minY" : 129, "maxY" : 217, "prop" : { "x" : 896, "y" : 130, "width" : 41, "height" : 30 }, "textPosition" : { "x" : 900, "y" : 134 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 932, "y" : 135 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 932, "y" : 135 } } }, "connectors" : [ { "edgeId" : 22838, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 898, "y" : 163 }, "to" : { "x" : 830, "y" : 217 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 895, "y" : 170 }, "b" : { "x" : 898, "y" : 163 }, "c" : { "x" : 890, "y" : 164 }, "type" : "ARROW", "centre" : { "x" : 890, "y" : 164 } } } ] }, { "id" : 22842, "reactomeId" : 11094020, "displayName" : "Homologues of GSK3B", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 807, "y" : 271 }, "minX" : 783, "maxX" : 832, "minY" : 225, "maxY" : 282, "prop" : { "x" : 783, "y" : 260, "width" : 49, "height" : 22 }, "textPosition" : { "x" : 782, "y" : 240 }, "connectors" : [ { "edgeId" : 22838, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 807, "y" : 257 }, "to" : { "x" : 808, "y" : 233 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 808, "y" : 229 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 808, "y" : 229 } } } ] }, { "id" : 22844, "reactomeId" : 11094601, "displayName" : "phospho-HSF1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 962, "y" : 283 }, "minX" : 903, "maxX" : 1027, "minY" : 266, "maxY" : 318, "prop" : { "x" : 903, "y" : 272, "width" : 118, "height" : 22 }, "textPosition" : { "x" : 912, "y" : 272 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1021, "y" : 272 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1021, "y" : 272 } } }, "connectors" : [ { "edgeId" : 22843, "type" : "INPUT", "segments" : [ { "from" : { "x" : 969, "y" : 297 }, "to" : { "x" : 985, "y" : 318 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 22845, "reactomeId" : 11094603, "displayName" : "p-S303,307-HSF1:YWHAE", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1097, "y" : 320 }, "minX" : 1036, "maxX" : 1164, "minY" : 296, "maxY" : 338, "prop" : { "x" : 1036, "y" : 302, "width" : 122, "height" : 36 }, "textPosition" : { "x" : 1037, "y" : 303 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1158, "y" : 302 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1158, "y" : 302 } } }, "connectors" : [ { "edgeId" : 22843, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 22847, "reactomeId" : 11094097, "displayName" : "SIRT1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1103, "y" : 959 }, "minX" : 1026, "maxX" : 1130, "minY" : 942, "maxY" : 996, "prop" : { "x" : 1082, "y" : 948, "width" : 42, "height" : 22 }, "textPosition" : { "x" : 1082, "y" : 948 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1124, "y" : 948 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1124, "y" : 948 } } }, "connectors" : [ { "edgeId" : 22846, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1079, "y" : 969 }, "to" : { "x" : 1026, "y" : 996 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 22848, "reactomeId" : 11094092, "displayName" : "HSP70:DNAJB1:Ac-K80-HSF1 trimer:target gene", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 973, "y" : 943 }, "minX" : 913, "maxX" : 1040, "minY" : 912, "maxY" : 996, "prop" : { "x" : 913, "y" : 918, "width" : 121, "height" : 50 }, "textPosition" : { "x" : 913, "y" : 919 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1034, "y" : 918 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1034, "y" : 918 } } }, "connectors" : [ { "edgeId" : 22846, "type" : "INPUT", "segments" : [ { "from" : { "x" : 998, "y" : 971 }, "to" : { "x" : 1026, "y" : 996 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 22849, "reactomeId" : 11094099, "displayName" : "SIRT1:HSP70:DNAJB1:Ac-K80-HSF1:target gene", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1029, "y" : 1107 }, "minX" : 808, "maxX" : 1095, "minY" : 1076, "maxY" : 1132, "prop" : { "x" : 969, "y" : 1082, "width" : 120, "height" : 50 }, "textPosition" : { "x" : 969, "y" : 1083 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1089, "y" : 1082 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1089, "y" : 1082 } } }, "connectors" : [ { "edgeId" : 22860, "type" : "INPUT", "segments" : [ { "from" : { "x" : 966, "y" : 1106 }, "to" : { "x" : 845, "y" : 1105 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 22860, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 966, "y" : 1099 }, "to" : { "x" : 812, "y" : 1079 } }, { "from" : { "x" : 812, "y" : 1079 }, "to" : { "x" : 812, "y" : 1090 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 812, "y" : 1094 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 812, "y" : 1094 } } }, { "edgeId" : 22846, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 22851, "reactomeId" : 11094643, "displayName" : "HSF1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 697, "y" : 538 }, "minX" : 653, "maxX" : 746, "minY" : 521, "maxY" : 549, "prop" : { "x" : 677, "y" : 527, "width" : 41, "height" : 22 }, "textPosition" : { "x" : 677, "y" : 527 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 718, "y" : 527 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 718, "y" : 527 } } }, "connectors" : [ { "edgeId" : 22850, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 3, "shape" : { "a" : { "x" : 734, "y" : 530 }, "b" : { "x" : 746, "y" : 542 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 740, "y" : 536 } } } }, { "edgeId" : 22852, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 674, "y" : 537 }, "to" : { "x" : 653, "y" : 537 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 667, "y" : 541 }, "b" : { "x" : 674, "y" : 537 }, "c" : { "x" : 667, "y" : 533 }, "type" : "ARROW", "centre" : { "x" : 667, "y" : 533 } } } ] }, { "id" : 22853, "reactomeId" : 11094673, "displayName" : "HSF1:HSP90:PTGES3", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 546, "y" : 537 }, "minX" : 482, "maxX" : 617, "minY" : 513, "maxY" : 555, "prop" : { "x" : 482, "y" : 519, "width" : 129, "height" : 36 }, "textPosition" : { "x" : 502, "y" : 520 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 611, "y" : 519 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 611, "y" : 519 } } }, "connectors" : [ { "edgeId" : 22852, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 22854, "reactomeId" : 11094665, "displayName" : "SBA1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 688, "y" : 491 }, "minX" : 653, "maxX" : 723, "minY" : 474, "maxY" : 537, "prop" : { "x" : 660, "y" : 480, "width" : 57, "height" : 22 }, "textPosition" : { "x" : 668, "y" : 480 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 717, "y" : 480 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 717, "y" : 480 } } }, "connectors" : [ { "edgeId" : 22852, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 679, "y" : 505 }, "to" : { "x" : 653, "y" : 537 } } ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 660, "y" : 515 }, "b" : { "x" : 672, "y" : 527 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 666, "y" : 521 } } }, "endShape" : { "a" : { "x" : 678, "y" : 513 }, "b" : { "x" : 679, "y" : 505 }, "c" : { "x" : 672, "y" : 508 }, "type" : "ARROW", "centre" : { "x" : 672, "y" : 508 } } } ] }, { "id" : 22855, "reactomeId" : 11094671, "displayName" : "HSP90:HSP90", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 678, "y" : 579 }, "minX" : 631, "maxX" : 726, "minY" : 537, "maxY" : 590, "prop" : { "x" : 631, "y" : 568, "width" : 95, "height" : 22 }, "textPosition" : { "x" : 631, "y" : 568 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "connectors" : [ { "edgeId" : 22852, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 671, "y" : 562 }, "to" : { "x" : 653, "y" : 537 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 664, "y" : 559 }, "b" : { "x" : 671, "y" : 562 }, "c" : { "x" : 670, "y" : 554 }, "type" : "ARROW", "centre" : { "x" : 670, "y" : 554 } } } ] }, { "id" : 22857, "reactomeId" : 11094081, "displayName" : "HSP70:DNAJB1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1163, "y" : 713 }, "minX" : 1112, "maxX" : 1219, "minY" : 696, "maxY" : 742, "prop" : { "x" : 1114, "y" : 702, "width" : 99, "height" : 22 }, "textPosition" : { "x" : 1114, "y" : 703 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1213, "y" : 702 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1213, "y" : 702 } } }, "connectors" : [ { "edgeId" : 22856, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1143, "y" : 727 }, "to" : { "x" : 1112, "y" : 742 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 22858, "reactomeId" : 11094105, "displayName" : "HSF1 trimer:target gene", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 964, "y" : 668 }, "minX" : 905, "maxX" : 1112, "minY" : 644, "maxY" : 742, "prop" : { "x" : 905, "y" : 650, "width" : 119, "height" : 36 }, "textPosition" : { "x" : 922, "y" : 651 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1024, "y" : 650 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1024, "y" : 650 } } }, "connectors" : [ { "edgeId" : 22856, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1000, "y" : 689 }, "to" : { "x" : 1112, "y" : 742 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 22866, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 22859, "reactomeId" : 11094107, "displayName" : "HSP70:DNAJB1:HSF1 trimer:target gene", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1020, "y" : 809 }, "minX" : 715, "maxX" : 1093, "minY" : 778, "maxY" : 1105, "prop" : { "x" : 954, "y" : 784, "width" : 133, "height" : 50 }, "textPosition" : { "x" : 956, "y" : 785 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1087, "y" : 784 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1087, "y" : 784 } } }, "connectors" : [ { "edgeId" : 22856, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 22860, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 951, "y" : 809 }, "to" : { "x" : 715, "y" : 811 } }, { "from" : { "x" : 715, "y" : 811 }, "to" : { "x" : 769, "y" : 1073 } }, { "from" : { "x" : 769, "y" : 1073 }, "to" : { "x" : 768, "y" : 1105 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 944, "y" : 813 }, "b" : { "x" : 951, "y" : 809 }, "c" : { "x" : 944, "y" : 805 }, "type" : "ARROW", "centre" : { "x" : 944, "y" : 805 } } } ] }, { "id" : 22861, "reactomeId" : 427523, "displayName" : "NAD+", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 1002, "y" : 1162 }, "minX" : 845, "maxX" : 1030, "minY" : 1105, "maxY" : 1177, "prop" : { "x" : 976, "y" : 1147, "width" : 53, "height" : 30 }, "textPosition" : { "x" : 980, "y" : 1151 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1024, "y" : 1152 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1024, "y" : 1152 } } }, "connectors" : [ { "edgeId" : 22860, "type" : "INPUT", "segments" : [ { "from" : { "x" : 973, "y" : 1152 }, "to" : { "x" : 845, "y" : 1105 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 22862, "reactomeId" : 113518, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 902, "y" : 1158 }, "minX" : 845, "maxX" : 925, "minY" : 1105, "maxY" : 1173, "prop" : { "x" : 881, "y" : 1143, "width" : 43, "height" : 30 }, "textPosition" : { "x" : 885, "y" : 1147 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 919, "y" : 1148 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 919, "y" : 1148 } } }, "connectors" : [ { "edgeId" : 22860, "type" : "INPUT", "segments" : [ { "from" : { "x" : 885, "y" : 1140 }, "to" : { "x" : 845, "y" : 1105 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 22863, "reactomeId" : 427498, "displayName" : "2'-O-acetyl-ADP-ribose", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 704, "y" : 1154 }, "minX" : 643, "maxX" : 768, "minY" : 1105, "maxY" : 1176, "prop" : { "x" : 643, "y" : 1132, "width" : 122, "height" : 44 }, "textPosition" : { "x" : 651, "y" : 1136 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 760, "y" : 1137 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 760, "y" : 1137 } } }, "connectors" : [ { "edgeId" : 22860, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 732, "y" : 1129 }, "to" : { "x" : 768, "y" : 1105 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 736, "y" : 1122 }, "b" : { "x" : 732, "y" : 1129 }, "c" : { "x" : 740, "y" : 1128 }, "type" : "ARROW", "centre" : { "x" : 740, "y" : 1128 } } } ] }, { "id" : 22864, "reactomeId" : 427497, "displayName" : "NAM", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 814, "y" : 1164 }, "minX" : 768, "maxX" : 837, "minY" : 1105, "maxY" : 1179, "prop" : { "x" : 792, "y" : 1149, "width" : 44, "height" : 30 }, "textPosition" : { "x" : 796, "y" : 1153 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 831, "y" : 1154 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 831, "y" : 1154 } } }, "connectors" : [ { "edgeId" : 22860, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 802, "y" : 1146 }, "to" : { "x" : 768, "y" : 1105 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 794, "y" : 1143 }, "b" : { "x" : 802, "y" : 1146 }, "c" : { "x" : 801, "y" : 1138 }, "type" : "ARROW", "centre" : { "x" : 801, "y" : 1138 } } } ] }, { "id" : 22865, "reactomeId" : 11094097, "displayName" : "SIRT1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 687, "y" : 1105 }, "minX" : 666, "maxX" : 768, "minY" : 1088, "maxY" : 1116, "prop" : { "x" : 666, "y" : 1094, "width" : 42, "height" : 22 }, "textPosition" : { "x" : 666, "y" : 1094 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 708, "y" : 1094 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 708, "y" : 1094 } } }, "connectors" : [ { "edgeId" : 22860, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 711, "y" : 1105 }, "to" : { "x" : 768, "y" : 1105 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 718, "y" : 1101 }, "b" : { "x" : 711, "y" : 1105 }, "c" : { "x" : 718, "y" : 1109 }, "type" : "ARROW", "centre" : { "x" : 718, "y" : 1109 } } } ] }, { "id" : 22867, "reactomeId" : 11094623, "displayName" : "Heat shock inducible proteins", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1293, "y" : 698 }, "minX" : 1229, "maxX" : 1358, "minY" : 673, "maxY" : 723, "prop" : { "x" : 1229, "y" : 673, "width" : 129, "height" : 50 }, "textPosition" : { "x" : 1233, "y" : 680 }, "connectors" : [ { "edgeId" : 22866, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 22868, "reactomeId" : 11094628, "displayName" : "p-S230-HSF1 trimer", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1191, "y" : 602 }, "minX" : 1127, "maxX" : 1262, "minY" : 585, "maxY" : 656, "prop" : { "x" : 1127, "y" : 591, "width" : 129, "height" : 22 }, "textPosition" : { "x" : 1127, "y" : 592 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1256, "y" : 591 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1256, "y" : 591 } } }, "connectors" : [ { "edgeId" : 22866, "type" : "ACTIVATOR", "segments" : [ { "from" : { "x" : 1187, "y" : 616 }, "to" : { "x" : 1179, "y" : 643 } }, { "from" : { "x" : 1179, "y" : 643 }, "to" : { "x" : 1180, "y" : 656 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 1175, "y" : 649 }, "b" : { "x" : 1180, "y" : 656 }, "c" : { "x" : 1183, "y" : 649 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 1183, "y" : 649 } } } ] }, { "id" : 22870, "reactomeId" : 11095403, "displayName" : "HSF1:HSP90:HDAC6:VCP:PTGES3", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 295, "y" : 242 }, "minX" : 230, "maxX" : 399, "minY" : 218, "maxY" : 285, "prop" : { "x" : 230, "y" : 224, "width" : 131, "height" : 36 }, "textPosition" : { "x" : 230, "y" : 225 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 361, "y" : 224 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 361, "y" : 224 } } }, "connectors" : [ { "edgeId" : 22869, "type" : "INPUT", "segments" : [ { "from" : { "x" : 317, "y" : 263 }, "to" : { "x" : 349, "y" : 285 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 22869, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 364, "y" : 259 }, "to" : { "x" : 392, "y" : 268 } }, { "from" : { "x" : 392, "y" : 268 }, "to" : { "x" : 393, "y" : 271 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 395, "y" : 274 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 395, "y" : 274 } } } ] }, { "id" : 22871, "reactomeId" : 5324631, "displayName" : "Ub-protein aggregates", "schemaClass" : "OtherEntity", "renderableClass" : "Entity", "position" : { "x" : 305, "y" : 316 }, "minX" : 264, "maxX" : 349, "minY" : 285, "maxY" : 334, "prop" : { "x" : 264, "y" : 298, "width" : 82, "height" : 36 }, "textPosition" : { "x" : 264, "y" : 298 }, "connectors" : [ { "edgeId" : 22869, "type" : "INPUT", "segments" : [ { "from" : { "x" : 330, "y" : 295 }, "to" : { "x" : 349, "y" : 285 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 22872, "reactomeId" : 11095405, "displayName" : "HDAC6:VCP:protein aggregates", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 522, "y" : 338 }, "minX" : 434, "maxX" : 594, "minY" : 286, "maxY" : 356, "prop" : { "x" : 456, "y" : 320, "width" : 132, "height" : 36 }, "textPosition" : { "x" : 456, "y" : 321 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 588, "y" : 320 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 588, "y" : 320 } } }, "connectors" : [ { "edgeId" : 22869, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 491, "y" : 317 }, "to" : { "x" : 434, "y" : 286 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 483, "y" : 317 }, "b" : { "x" : 491, "y" : 317 }, "c" : { "x" : 487, "y" : 310 }, "type" : "ARROW", "centre" : { "x" : 487, "y" : 310 } } } ] }, { "id" : 22874, "reactomeId" : 11095195, "displayName" : "HSP70s:ATP", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 211, "y" : 1047 }, "minX" : 144, "maxX" : 253, "minY" : 926, "maxY" : 1096, "prop" : { "x" : 170, "y" : 1036, "width" : 83, "height" : 22 }, "textPosition" : { "x" : 170, "y" : 1036 }, "connectors" : [ { "edgeId" : 22883, "type" : "INPUT", "segments" : [ { "from" : { "x" : 211, "y" : 1030 }, "to" : { "x" : 211, "y" : 926 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 22873, "type" : "INPUT", "segments" : [ { "from" : { "x" : 210, "y" : 1064 }, "to" : { "x" : 209, "y" : 1091 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 22879, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 195, "y" : 1064 }, "to" : { "x" : 144, "y" : 1096 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 191, "y" : 1071 }, "b" : { "x" : 195, "y" : 1064 }, "c" : { "x" : 187, "y" : 1064 }, "type" : "ARROW", "centre" : { "x" : 187, "y" : 1064 } } } ] }, { "id" : 22875, "reactomeId" : 29356, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 291, "y" : 1063 }, "minX" : 209, "maxX" : 314, "minY" : 1047, "maxY" : 1091, "prop" : { "x" : 269, "y" : 1048, "width" : 44, "height" : 30 }, "textPosition" : { "x" : 274, "y" : 1052 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 308, "y" : 1053 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 308, "y" : 1053 } } }, "connectors" : [ { "edgeId" : 22873, "type" : "INPUT", "segments" : [ { "from" : { "x" : 266, "y" : 1070 }, "to" : { "x" : 209, "y" : 1091 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 22876, "reactomeId" : 11095371, "displayName" : "HSP70s:ADP", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 277, "y" : 1203 }, "minX" : 144, "maxX" : 320, "minY" : 1152, "maxY" : 1214, "prop" : { "x" : 234, "y" : 1192, "width" : 86, "height" : 22 }, "textPosition" : { "x" : 234, "y" : 1192 }, "connectors" : [ { "edgeId" : 22873, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 277, "y" : 1186 }, "to" : { "x" : 277, "y" : 1152 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 273, "y" : 1179 }, "b" : { "x" : 277, "y" : 1186 }, "c" : { "x" : 281, "y" : 1179 }, "type" : "ARROW", "centre" : { "x" : 281, "y" : 1179 } } }, { "edgeId" : 22879, "type" : "INPUT", "segments" : [ { "from" : { "x" : 239, "y" : 1186 }, "to" : { "x" : 144, "y" : 1164 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 22877, "reactomeId" : 29372, "displayName" : "Pi", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 337, "y" : 1173 }, "minX" : 277, "maxX" : 355, "minY" : 1152, "maxY" : 1187, "prop" : { "x" : 321, "y" : 1160, "width" : 33, "height" : 27 }, "textPosition" : { "x" : 328, "y" : 1163 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 349, "y" : 1165 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 349, "y" : 1165 } } }, "connectors" : [ { "edgeId" : 22873, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 318, "y" : 1167 }, "to" : { "x" : 277, "y" : 1152 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 310, "y" : 1168 }, "b" : { "x" : 318, "y" : 1167 }, "c" : { "x" : 313, "y" : 1161 }, "type" : "ARROW", "centre" : { "x" : 313, "y" : 1161 } } } ] }, { "id" : 22878, "reactomeId" : 11095375, "displayName" : "DNAJB1,B6,C2,C7", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 390, "y" : 1116 }, "minX" : 286, "maxX" : 447, "minY" : 1105, "maxY" : 1127, "prop" : { "x" : 334, "y" : 1105, "width" : 113, "height" : 22 }, "textPosition" : { "x" : 334, "y" : 1105 }, "connectors" : [ { "edgeId" : 22873, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 328, "y" : 1117 }, "to" : { "x" : 294, "y" : 1118 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 290, "y" : 1119 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 290, "y" : 1119 } } } ] }, { "id" : 22880, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 106, "y" : 1204 }, "minX" : 86, "maxX" : 144, "minY" : 1164, "maxY" : 1219, "prop" : { "x" : 86, "y" : 1189, "width" : 41, "height" : 30 }, "textPosition" : { "x" : 91, "y" : 1193 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 122, "y" : 1194 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 122, "y" : 1194 } } }, "connectors" : [ { "edgeId" : 22879, "type" : "INPUT", "segments" : [ { "from" : { "x" : 120, "y" : 1186 }, "to" : { "x" : 144, "y" : 1164 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 22881, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 104, "y" : 1048 }, "minX" : 84, "maxX" : 144, "minY" : 1032, "maxY" : 1096, "prop" : { "x" : 84, "y" : 1033, "width" : 41, "height" : 30 }, "textPosition" : { "x" : 88, "y" : 1037 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 120, "y" : 1038 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 120, "y" : 1038 } } }, "connectors" : [ { "edgeId" : 22879, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 116, "y" : 1066 }, "to" : { "x" : 144, "y" : 1096 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 124, "y" : 1068 }, "b" : { "x" : 116, "y" : 1066 }, "c" : { "x" : 118, "y" : 1074 }, "type" : "ARROW", "centre" : { "x" : 118, "y" : 1074 } } } ] }, { "id" : 22882, "reactomeId" : 11095392, "displayName" : "SSE1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 71, "y" : 1133 }, "minX" : 29, "maxX" : 136, "minY" : 1116, "maxY" : 1144, "prop" : { "x" : 29, "y" : 1122, "width" : 85, "height" : 22 }, "textPosition" : { "x" : 51, "y" : 1122 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 114, "y" : 1122 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 114, "y" : 1122 } } }, "connectors" : [ { "edgeId" : 22879, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 120, "y" : 1134 }, "to" : { "x" : 128, "y" : 1134 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 132, "y" : 1135 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 132, "y" : 1135 } } } ] }, { "id" : 22884, "reactomeId" : 11095080, "displayName" : "OPI10", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 150, "y" : 895 }, "minX" : 122, "maxX" : 211, "minY" : 878, "maxY" : 926, "prop" : { "x" : 122, "y" : 884, "width" : 57, "height" : 22 }, "textPosition" : { "x" : 128, "y" : 884 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 179, "y" : 884 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 179, "y" : 884 } } }, "connectors" : [ { "edgeId" : 22883, "type" : "INPUT", "segments" : [ { "from" : { "x" : 171, "y" : 909 }, "to" : { "x" : 211, "y" : 926 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 22885, "reactomeId" : 11095197, "displayName" : "Hikeshi:HSP70s:ATP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 319, "y" : 855 }, "minX" : 256, "maxX" : 388, "minY" : 831, "maxY" : 873, "prop" : { "x" : 256, "y" : 837, "width" : 126, "height" : 36 }, "textPosition" : { "x" : 264, "y" : 838 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 382, "y" : 837 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 382, "y" : 837 } } }, "connectors" : [ { "edgeId" : 22883, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 22887, "reactomeId" : 11095309, "displayName" : "Hikeshi:HSP70s:ATP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 562, "y" : 855 }, "minX" : 499, "maxX" : 631, "minY" : 831, "maxY" : 900, "prop" : { "x" : 499, "y" : 837, "width" : 126, "height" : 36 }, "textPosition" : { "x" : 507, "y" : 838 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 625, "y" : 837 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 625, "y" : 837 } } }, "connectors" : [ { "edgeId" : 22886, "type" : "INPUT", "segments" : [ { "from" : { "x" : 562, "y" : 876 }, "to" : { "x" : 562, "y" : 900 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 22888, "reactomeId" : 113518, "displayName" : "H2O", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 620, "y" : 888 }, "minX" : 562, "maxX" : 643, "minY" : 872, "maxY" : 903, "prop" : { "x" : 598, "y" : 873, "width" : 44, "height" : 30 }, "textPosition" : { "x" : 603, "y" : 877 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 637, "y" : 878 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 637, "y" : 878 } } }, "connectors" : [ { "edgeId" : 22886, "type" : "INPUT", "segments" : [ { "from" : { "x" : 595, "y" : 892 }, "to" : { "x" : 562, "y" : 900 } } ], "stoichiometry" : { "value" : 1 } } ], "trivial" : true }, { "id" : 22889, "reactomeId" : 11095335, "displayName" : "HSP70s:ADP", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 569, "y" : 1057 }, "minX" : 526, "maxX" : 612, "minY" : 987, "maxY" : 1068, "prop" : { "x" : 526, "y" : 1046, "width" : 86, "height" : 22 }, "textPosition" : { "x" : 526, "y" : 1046 }, "connectors" : [ { "edgeId" : 22886, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 568, "y" : 1040 }, "to" : { "x" : 568, "y" : 987 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 564, "y" : 1033 }, "b" : { "x" : 568, "y" : 1040 }, "c" : { "x" : 572, "y" : 1033 }, "type" : "ARROW", "centre" : { "x" : 572, "y" : 1033 } } } ] }, { "id" : 22890, "reactomeId" : 113550, "displayName" : "Pi", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 621, "y" : 1023 }, "minX" : 568, "maxX" : 635, "minY" : 987, "maxY" : 1038, "prop" : { "x" : 608, "y" : 1008, "width" : 26, "height" : 30 }, "textPosition" : { "x" : 611, "y" : 1012 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 629, "y" : 1013 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 629, "y" : 1013 } } }, "connectors" : [ { "edgeId" : 22886, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 605, "y" : 1014 }, "to" : { "x" : 568, "y" : 987 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 597, "y" : 1013 }, "b" : { "x" : 605, "y" : 1014 }, "c" : { "x" : 602, "y" : 1007 }, "type" : "ARROW", "centre" : { "x" : 602, "y" : 1007 } } } ] }, { "id" : 22891, "reactomeId" : 11095307, "displayName" : "OPI10", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 641, "y" : 989 }, "minX" : 568, "maxX" : 674, "minY" : 972, "maxY" : 1000, "prop" : { "x" : 614, "y" : 978, "width" : 54, "height" : 22 }, "textPosition" : { "x" : 619, "y" : 978 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 668, "y" : 978 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 668, "y" : 978 } } }, "connectors" : [ { "edgeId" : 22886, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 611, "y" : 988 }, "to" : { "x" : 568, "y" : 987 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 604, "y" : 992 }, "b" : { "x" : 611, "y" : 988 }, "c" : { "x" : 604, "y" : 984 }, "type" : "ARROW", "centre" : { "x" : 604, "y" : 984 } } } ] }, { "id" : 22892, "reactomeId" : 11095342, "displayName" : "DNAJB1,B6,C2,C7", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 474, "y" : 943 }, "minX" : 418, "maxX" : 560, "minY" : 932, "maxY" : 954, "prop" : { "x" : 418, "y" : 932, "width" : 113, "height" : 22 }, "textPosition" : { "x" : 418, "y" : 932 }, "connectors" : [ { "edgeId" : 22886, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 537, "y" : 942 }, "to" : { "x" : 552, "y" : 942 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 556, "y" : 942 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 556, "y" : 942 } } } ] } ], "edges" : [ { "id" : 22850, "reactomeId" : 11094645, "displayName" : "Trimerization of HSF1 in the nucleus", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 759, "y" : 536 }, "minX" : 721, "maxX" : 789, "minY" : 530, "maxY" : 542, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 721, "y" : 537 }, "to" : { "x" : 759, "y" : 536 } }, { "from" : { "x" : 759, "y" : 536 }, "to" : { "x" : 789, "y" : 535 } } ], "endShape" : { "a" : { "x" : 782, "y" : 539 }, "b" : { "x" : 789, "y" : 535 }, "c" : { "x" : 782, "y" : 531 }, "type" : "ARROW", "centre" : { "x" : 782, "y" : 531 } }, "reactionShape" : { "c" : { "x" : 759, "y" : 536 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 759, "y" : 536 } }, "inputs" : [ { "id" : 22851, "stoichiometry" : 3 } ], "outputs" : [ { "id" : 22831 } ] }, { "id" : 22883, "reactomeId" : 11095199, "displayName" : "Hikeshi binds HSP70s:ATP", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 209, "y" : 924 }, "minX" : 203, "maxX" : 290, "minY" : 876, "maxY" : 930, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 211, "y" : 926 }, "to" : { "x" : 209, "y" : 924 } }, { "from" : { "x" : 209, "y" : 924 }, "to" : { "x" : 290, "y" : 876 } } ], "endShape" : { "a" : { "x" : 286, "y" : 883 }, "b" : { "x" : 290, "y" : 876 }, "c" : { "x" : 282, "y" : 876 }, "type" : "ARROW", "centre" : { "x" : 282, "y" : 876 } }, "reactionShape" : { "c" : { "x" : 209, "y" : 924 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 209, "y" : 924 } }, "inputs" : [ { "id" : 22874, "points" : [ { "x" : 211, "y" : 1030 } ] }, { "id" : 22884, "points" : [ { "x" : 171, "y" : 909 } ] } ], "outputs" : [ { "id" : 22885 } ] }, { "id" : 22852, "reactomeId" : 11094675, "displayName" : "Dissociation of HSF1:HSP90 complex in the nucleus", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 631, "y" : 537 }, "minX" : 614, "maxX" : 653, "minY" : 531, "maxY" : 543, "reactionType" : "dissociation", "segments" : [ { "from" : { "x" : 614, "y" : 537 }, "to" : { "x" : 631, "y" : 537 } }, { "from" : { "x" : 631, "y" : 537 }, "to" : { "x" : 653, "y" : 537 } } ], "reactionShape" : { "c" : { "x" : 631, "y" : 537 }, "r" : 5, "r1" : 3, "type" : "DOUBLE_CIRCLE", "empty" : true, "centre" : { "x" : 631, "y" : 537 } }, "inputs" : [ { "id" : 22853 } ], "outputs" : [ { "id" : 22854, "points" : [ { "x" : 679, "y" : 505 } ], "stoichiometry" : 2 }, { "id" : 22855, "points" : [ { "x" : 671, "y" : 562 } ] }, { "id" : 22851, "points" : [ { "x" : 674, "y" : 537 } ] } ] }, { "id" : 22822, "reactomeId" : 11094145, "displayName" : "Dissociation of cytosolic HSF1:HSP90 complex", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 443, "y" : 181 }, "minX" : 368, "maxX" : 470, "minY" : 175, "maxY" : 190, "reactionType" : "dissociation", "segments" : [ { "from" : { "x" : 368, "y" : 182 }, "to" : { "x" : 443, "y" : 181 } }, { "from" : { "x" : 443, "y" : 181 }, "to" : { "x" : 470, "y" : 190 } } ], "reactionShape" : { "c" : { "x" : 443, "y" : 181 }, "r" : 5, "r1" : 3, "type" : "DOUBLE_CIRCLE", "empty" : true, "centre" : { "x" : 443, "y" : 181 } }, "inputs" : [ { "id" : 22823 } ], "outputs" : [ { "id" : 22824, "points" : [ { "x" : 615, "y" : 219 } ] }, { "id" : 22825, "points" : [ { "x" : 470, "y" : 225 } ], "stoichiometry" : 2 }, { "id" : 22826, "points" : [ { "x" : 541, "y" : 230 } ] } ] }, { "id" : 22886, "reactomeId" : 11095345, "displayName" : "HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 568, "y" : 942 }, "minX" : 562, "maxX" : 574, "minY" : 900, "maxY" : 987, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 562, "y" : 900 }, "to" : { "x" : 568, "y" : 942 } }, { "from" : { "x" : 568, "y" : 942 }, "to" : { "x" : 568, "y" : 987 } } ], "reactionShape" : { "a" : { "x" : 562, "y" : 936 }, "b" : { "x" : 574, "y" : 948 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 568, "y" : 942 } }, "inputs" : [ { "id" : 22887, "points" : [ { "x" : 562, "y" : 876 } ] }, { "id" : 22888, "points" : [ { "x" : 595, "y" : 892 } ] } ], "outputs" : [ { "id" : 22889, "points" : [ { "x" : 568, "y" : 1040 } ] }, { "id" : 22890, "points" : [ { "x" : 605, "y" : 1014 } ] }, { "id" : 22891, "points" : [ { "x" : 611, "y" : 988 } ] } ], "catalysts" : [ { "id" : 22892, "points" : [ { "x" : 537, "y" : 942 } ] } ] }, { "id" : 22856, "reactomeId" : 11094641, "displayName" : "HSP70:DNAJB1 binds HSF1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1111, "y" : 773 }, "minX" : 1083, "maxX" : 1117, "minY" : 742, "maxY" : 781, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1112, "y" : 742 }, "to" : { "x" : 1111, "y" : 773 } }, { "from" : { "x" : 1111, "y" : 773 }, "to" : { "x" : 1083, "y" : 781 } } ], "endShape" : { "a" : { "x" : 1089, "y" : 775 }, "b" : { "x" : 1083, "y" : 781 }, "c" : { "x" : 1091, "y" : 783 }, "type" : "ARROW", "centre" : { "x" : 1091, "y" : 783 } }, "reactionShape" : { "c" : { "x" : 1111, "y" : 773 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1111, "y" : 773 } }, "inputs" : [ { "id" : 22857, "points" : [ { "x" : 1143, "y" : 727 } ] }, { "id" : 22858, "points" : [ { "x" : 1000, "y" : 689 } ] } ], "outputs" : [ { "id" : 22859 } ] }, { "id" : 22827, "reactomeId" : 11094153, "displayName" : "Trimerization of cytosolic HSF1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 638, "y" : 275 }, "minX" : 632, "maxX" : 668, "minY" : 238, "maxY" : 316, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 638, "y" : 238 }, "to" : { "x" : 638, "y" : 275 } }, { "from" : { "x" : 638, "y" : 275 }, "to" : { "x" : 668, "y" : 316 } } ], "endShape" : { "a" : { "x" : 661, "y" : 313 }, "b" : { "x" : 668, "y" : 316 }, "c" : { "x" : 667, "y" : 308 }, "type" : "ARROW", "centre" : { "x" : 667, "y" : 308 } }, "reactionShape" : { "c" : { "x" : 638, "y" : 275 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 638, "y" : 275 } }, "inputs" : [ { "id" : 22824, "stoichiometry" : 3 } ], "outputs" : [ { "id" : 22828 } ], "activators" : [ { "id" : 22829, "points" : [ { "x" : 664, "y" : 275 } ] } ] }, { "id" : 22860, "reactomeId" : 11094110, "displayName" : "SIRT1 deacetylates HSF1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 812, "y" : 1106 }, "minX" : 768, "maxX" : 845, "minY" : 1100, "maxY" : 1112, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 845, "y" : 1105 }, "to" : { "x" : 812, "y" : 1106 } }, { "from" : { "x" : 812, "y" : 1106 }, "to" : { "x" : 768, "y" : 1105 } } ], "reactionShape" : { "a" : { "x" : 806, "y" : 1100 }, "b" : { "x" : 818, "y" : 1112 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 812, "y" : 1106 } }, "inputs" : [ { "id" : 22849, "points" : [ { "x" : 966, "y" : 1106 } ] }, { "id" : 22861, "points" : [ { "x" : 973, "y" : 1152 } ] }, { "id" : 22862, "points" : [ { "x" : 885, "y" : 1140 } ] } ], "outputs" : [ { "id" : 22863, "points" : [ { "x" : 732, "y" : 1129 } ] }, { "id" : 22859, "points" : [ { "x" : 951, "y" : 809 }, { "x" : 715, "y" : 811 }, { "x" : 769, "y" : 1073 } ] }, { "id" : 22864, "points" : [ { "x" : 802, "y" : 1146 } ] }, { "id" : 22865, "points" : [ { "x" : 711, "y" : 1105 } ] } ], "catalysts" : [ { "id" : 22849, "points" : [ { "x" : 966, "y" : 1099 }, { "x" : 812, "y" : 1079 } ] } ] }, { "id" : 22830, "reactomeId" : 11094137, "displayName" : "HSF1 trimer translocates to the nucleus", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 829, "y" : 440 }, "minX" : 691, "maxX" : 835, "minY" : 344, "maxY" : 521, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 691, "y" : 344 }, "to" : { "x" : 829, "y" : 440 } }, { "from" : { "x" : 829, "y" : 440 }, "to" : { "x" : 832, "y" : 521 } } ], "endShape" : { "a" : { "x" : 828, "y" : 514 }, "b" : { "x" : 832, "y" : 521 }, "c" : { "x" : 836, "y" : 514 }, "type" : "ARROW", "centre" : { "x" : 836, "y" : 514 } }, "reactionShape" : { "a" : { "x" : 823, "y" : 434 }, "b" : { "x" : 835, "y" : 446 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 829, "y" : 440 } }, "inputs" : [ { "id" : 22828 } ], "outputs" : [ { "id" : 22831 } ], "inhibitors" : [ { "id" : 22832, "points" : [ { "x" : 936, "y" : 361 }, { "x" : 853, "y" : 419 } ] } ] }, { "id" : 22833, "reactomeId" : 11094663, "displayName" : "Phosphorylation of HSF1 at Ser326 induces transactivation", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 967, "y" : 498 }, "minX" : 934, "maxX" : 1001, "minY" : 492, "maxY" : 504, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 934, "y" : 499 }, "to" : { "x" : 967, "y" : 498 } }, { "from" : { "x" : 967, "y" : 498 }, "to" : { "x" : 1001, "y" : 498 } } ], "reactionShape" : { "a" : { "x" : 961, "y" : 492 }, "b" : { "x" : 973, "y" : 504 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 967, "y" : 498 } }, "inputs" : [ { "id" : 22831, "points" : [ { "x" : 863, "y" : 521 } ] }, { "id" : 22834, "points" : [ { "x" : 892, "y" : 479 } ] } ], "outputs" : [ { "id" : 22835, "points" : [ { "x" : 1168, "y" : 540 } ] }, { "id" : 22836, "points" : [ { "x" : 1083, "y" : 477 } ] } ], "catalysts" : [ { "id" : 22837, "points" : [ { "x" : 966, "y" : 474 } ] } ] }, { "id" : 22866, "reactomeId" : 11094635, "displayName" : "HSF1-mediated gene expression", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 1180, "y" : 665 }, "minX" : 1027, "maxX" : 1223, "minY" : 659, "maxY" : 679, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 1027, "y" : 667 }, "to" : { "x" : 1180, "y" : 665 } }, { "from" : { "x" : 1180, "y" : 665 }, "to" : { "x" : 1223, "y" : 679 } } ], "endShape" : { "a" : { "x" : 1215, "y" : 681 }, "b" : { "x" : 1223, "y" : 679 }, "c" : { "x" : 1218, "y" : 673 }, "type" : "ARROW", "centre" : { "x" : 1218, "y" : 673 } }, "reactionShape" : { "a" : { "x" : 1174, "y" : 659 }, "b" : { "x" : 1186, "y" : 671 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 1180, "y" : 665 } }, "inputs" : [ { "id" : 22858 } ], "outputs" : [ { "id" : 22867 } ], "activators" : [ { "id" : 22868, "points" : [ { "x" : 1187, "y" : 616 }, { "x" : 1179, "y" : 643 } ] }, { "id" : 22835, "points" : [ { "x" : 1278, "y" : 556 }, { "x" : 1300, "y" : 558 }, { "x" : 1301, "y" : 602 } ] } ] }, { "id" : 22869, "reactomeId" : 11095408, "displayName" : "Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 400, "y" : 285 }, "minX" : 349, "maxX" : 434, "minY" : 279, "maxY" : 291, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 349, "y" : 285 }, "to" : { "x" : 400, "y" : 285 } }, { "from" : { "x" : 400, "y" : 285 }, "to" : { "x" : 434, "y" : 286 } } ], "reactionShape" : { "a" : { "x" : 394, "y" : 279 }, "b" : { "x" : 406, "y" : 291 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 400, "y" : 285 } }, "inputs" : [ { "id" : 22870, "points" : [ { "x" : 317, "y" : 263 } ] }, { "id" : 22871, "points" : [ { "x" : 330, "y" : 295 } ] } ], "outputs" : [ { "id" : 22826, "points" : [ { "x" : 523, "y" : 264 } ] }, { "id" : 22824, "points" : [ { "x" : 632, "y" : 238 }, { "x" : 608, "y" : 281 } ] }, { "id" : 22872, "points" : [ { "x" : 491, "y" : 317 } ] }, { "id" : 22825, "points" : [ { "x" : 461, "y" : 253 } ], "stoichiometry" : 2 } ], "catalysts" : [ { "id" : 22870, "points" : [ { "x" : 364, "y" : 259 }, { "x" : 392, "y" : 268 } ] } ] }, { "id" : 22838, "reactomeId" : 11094023, "displayName" : "Constitutive phosphorylation by GSK3", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 808, "y" : 217 }, "minX" : 785, "maxX" : 830, "minY" : 211, "maxY" : 223, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 785, "y" : 217 }, "to" : { "x" : 808, "y" : 217 } }, { "from" : { "x" : 808, "y" : 217 }, "to" : { "x" : 830, "y" : 217 } } ], "reactionShape" : { "a" : { "x" : 802, "y" : 211 }, "b" : { "x" : 814, "y" : 223 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 808, "y" : 217 } }, "inputs" : [ { "id" : 22839, "points" : [ { "x" : 737, "y" : 170 } ] }, { "id" : 22824, "points" : [ { "x" : 662, "y" : 223 } ] } ], "outputs" : [ { "id" : 22840, "points" : [ { "x" : 912, "y" : 235 } ] }, { "id" : 22841, "points" : [ { "x" : 898, "y" : 163 } ] } ], "catalysts" : [ { "id" : 22842, "points" : [ { "x" : 807, "y" : 257 } ] } ] }, { "id" : 22873, "reactomeId" : 11095378, "displayName" : "HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 278, "y" : 1119 }, "minX" : 209, "maxX" : 284, "minY" : 1091, "maxY" : 1152, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 209, "y" : 1091 }, "to" : { "x" : 278, "y" : 1119 } }, { "from" : { "x" : 278, "y" : 1119 }, "to" : { "x" : 277, "y" : 1152 } } ], "reactionShape" : { "a" : { "x" : 272, "y" : 1113 }, "b" : { "x" : 284, "y" : 1125 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 278, "y" : 1119 } }, "inputs" : [ { "id" : 22874, "points" : [ { "x" : 210, "y" : 1064 } ] }, { "id" : 22875, "points" : [ { "x" : 266, "y" : 1070 } ] } ], "outputs" : [ { "id" : 22876, "points" : [ { "x" : 277, "y" : 1186 } ] }, { "id" : 22877, "points" : [ { "x" : 318, "y" : 1167 } ] } ], "catalysts" : [ { "id" : 22878, "points" : [ { "x" : 328, "y" : 1117 } ] } ] }, { "id" : 22843, "reactomeId" : 11094605, "displayName" : "p-S303,307-HSF1 binds YWHAE (14-3-3)", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1007, "y" : 318 }, "minX" : 985, "maxX" : 1033, "minY" : 312, "maxY" : 324, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 985, "y" : 318 }, "to" : { "x" : 1007, "y" : 318 } }, { "from" : { "x" : 1007, "y" : 318 }, "to" : { "x" : 1033, "y" : 318 } } ], "endShape" : { "a" : { "x" : 1026, "y" : 322 }, "b" : { "x" : 1033, "y" : 318 }, "c" : { "x" : 1026, "y" : 314 }, "type" : "ARROW", "centre" : { "x" : 1026, "y" : 314 } }, "reactionShape" : { "c" : { "x" : 1007, "y" : 318 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1007, "y" : 318 } }, "inputs" : [ { "id" : 22832, "points" : [ { "x" : 964, "y" : 333 } ] }, { "id" : 22844, "points" : [ { "x" : 969, "y" : 297 } ] } ], "outputs" : [ { "id" : 22845 } ] }, { "id" : 22846, "reactomeId" : 11094131, "displayName" : "SIRT1 binds to HSF1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1027, "y" : 1023 }, "minX" : 1021, "maxX" : 1033, "minY" : 996, "maxY" : 1079, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1026, "y" : 996 }, "to" : { "x" : 1027, "y" : 1023 } }, { "from" : { "x" : 1027, "y" : 1023 }, "to" : { "x" : 1028, "y" : 1079 } } ], "endShape" : { "a" : { "x" : 1024, "y" : 1072 }, "b" : { "x" : 1028, "y" : 1079 }, "c" : { "x" : 1032, "y" : 1072 }, "type" : "ARROW", "centre" : { "x" : 1032, "y" : 1072 } }, "reactionShape" : { "c" : { "x" : 1027, "y" : 1023 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1027, "y" : 1023 } }, "inputs" : [ { "id" : 22847, "points" : [ { "x" : 1079, "y" : 969 } ] }, { "id" : 22848, "points" : [ { "x" : 998, "y" : 971 } ] } ], "outputs" : [ { "id" : 22849 } ] }, { "id" : 22879, "reactomeId" : 11095395, "displayName" : "HSP110s exchange ATP for ADP on HSP70s:ADP", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 144, "y" : 1135 }, "minX" : 138, "maxX" : 150, "minY" : 1096, "maxY" : 1164, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 144, "y" : 1164 }, "to" : { "x" : 144, "y" : 1135 } }, { "from" : { "x" : 144, "y" : 1135 }, "to" : { "x" : 144, "y" : 1096 } } ], "reactionShape" : { "a" : { "x" : 138, "y" : 1129 }, "b" : { "x" : 150, "y" : 1141 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 144, "y" : 1135 } }, "inputs" : [ { "id" : 22876, "points" : [ { "x" : 239, "y" : 1186 } ] }, { "id" : 22880, "points" : [ { "x" : 120, "y" : 1186 } ] } ], "outputs" : [ { "id" : 22874, "points" : [ { "x" : 195, "y" : 1064 } ] }, { "id" : 22881, "points" : [ { "x" : 116, "y" : 1066 } ] } ], "catalysts" : [ { "id" : 22882, "points" : [ { "x" : 120, "y" : 1134 } ] } ] } ], "compartments" : [ { "id" : 22893, "reactomeId" : 70101, "displayName" : "cytosol", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 852, "y" : 626 }, "minX" : 0, "maxX" : 1704, "minY" : 0, "maxY" : 1253, "prop" : { "x" : 0, "y" : 0, "width" : 1704, "height" : 1253 }, "textPosition" : { "x" : 1106, "y" : 59 }, "insets" : { "x" : 10, "y" : 10, "width" : 1684, "height" : 1233 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 22822, 22823, 22826, 22894, 22824, 22825, 22827, 22828, 22829, 22832, 22838, 22839, 22840, 22841, 22842, 22843, 22844, 22845, 22904, 22872, 22869, 22870, 22871, 22873, 22874, 22875, 22876, 22879, 22880, 22881, 22883, 22884, 22885, 22877, 22882, 22878 ] }, { "id" : 22894, "reactomeId" : 7660, "displayName" : "nucleoplasm", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 923, "y" : 821 }, "minX" : 455, "maxX" : 1392, "minY" : 434, "maxY" : 1209, "prop" : { "x" : 455, "y" : 434, "width" : 937, "height" : 775 }, "textPosition" : { "x" : 503, "y" : 454 }, "insets" : { "x" : 465, "y" : 444, "width" : 917, "height" : 755 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 22831, 22858, 22833, 22835, 22868, 22830, 22846, 22847, 22850, 22851, 22852, 22853, 22854, 22855, 22856, 22857, 22859, 22848, 22849, 22860, 22861, 22865, 22866, 22834, 22836, 22837, 22864, 22862, 22905, 22863, 22867, 22887, 22890, 22891, 22888, 22889, 22892, 22886 ] } ], "notes" : [ { "id" : 22904, "displayName" : "STRESS", "renderableClass" : "Note", "position" : { "x" : 400, "y" : 171 }, "minX" : 370, "maxX" : 430, "minY" : 155, "maxY" : 187, "prop" : { "x" : 370, "y" : 155, "width" : 60, "height" : 32 }, "textPosition" : { "x" : 372, "y" : 160 } }, { "id" : 22905, "displayName" : "STRESS", "renderableClass" : "Note", "position" : { "x" : 631, "y" : 520 }, "minX" : 601, "maxX" : 661, "minY" : 504, "maxY" : 536, "prop" : { "x" : 601, "y" : 504, "width" : 60, "height" : 32 }, "textPosition" : { "x" : 603, "y" : 509 } } ], "links" : [ ], "shadows" : [ { "id" : 22906, "reactomeId" : 11107824, "displayName" : "Regulation of HSF1-mediated heat shock response", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 593, "y" : 674 }, "minX" : 19, "maxX" : 1168, "minY" : 120, "maxY" : 1229, "prop" : { "x" : 19, "y" : 844, "width" : 1149, "height" : 385 }, "points" : [ { "x" : 19, "y" : 120 }, { "x" : 1168, "y" : 120 }, { "x" : 1168, "y" : 1229 }, { "x" : 19, "y" : 1229 } ], "colour" : "#4684ee" }, { "id" : 22907, "reactomeId" : 11107828, "displayName" : "HSF1 activation", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 614, "y" : 378 }, "minX" : 220, "maxX" : 1008, "minY" : 156, "maxY" : 600, "prop" : { "x" : 220, "y" : 156, "width" : 788, "height" : 283 }, "points" : [ { "x" : 220, "y" : 156 }, { "x" : 1008, "y" : 156 }, { "x" : 1008, "y" : 600 }, { "x" : 220, "y" : 600 } ], "colour" : "#dc3912" }, { "id" : 22908, "reactomeId" : 11107852, "displayName" : "HSF1-dependent transactivation", "schemaClass" : "Pathway", "renderableClass" : "Shadow", "position" : { "x" : 1075, "y" : 641 }, "minX" : 782, "maxX" : 1368, "minY" : 439, "maxY" : 844, "prop" : { "x" : 1168, "y" : 439, "width" : 200, "height" : 405 }, "points" : [ { "x" : 782, "y" : 439 }, { "x" : 1368, "y" : 439 }, { "x" : 1368, "y" : 844 }, { "x" : 782, "y" : 844 } ], "colour" : "#008000" } ], "minX" : 0, "maxX" : 1704, "minY" : 0, "maxY" : 1253, "disease" : false }