{
  "dbId" : 10225445,
  "stId" : "R-RNO-9840373",
  "speciesName" : "Rattus norvegicus",
  "nodes" : [ {
    "dbId" : 10133816,
    "stId" : "R-RNO-9633006",
    "displayName" : "p-S52-EIF2S1:EIF2S2:EIF2S3 [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 48895,
    "diagramIds" : [ 115554 ],
    "parents" : [ ],
    "children" : [ 10106533, 10133814, 10106540 ]
  }, {
    "dbId" : 3777117,
    "stId" : "R-ALL-3777117",
    "displayName" : "Zn2+ [mitochondrial intermembrane space]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 115539 ],
    "identifier" : "29105",
    "standardIdentifier" : "chebi:29105",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10133814,
    "stId" : "R-RNO-381060",
    "displayName" : "phospho-Eif2s1 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48895,
    "identifier" : "P68101",
    "standardIdentifier" : "uniprot:P68101",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Eif2s1" ],
    "parents" : [ 10133816 ],
    "children" : [ ]
  }, {
    "dbId" : 189422,
    "stId" : "R-ALL-189422",
    "displayName" : "H2O [mitochondrial intermembrane space]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 115543 ],
    "identifier" : "15377",
    "standardIdentifier" : "chebi:15377",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10217622,
    "stId" : "R-RNO-9840385",
    "displayName" : "DELE1(143-515):EIF2AK1 [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 48895,
    "diagramIds" : [ 115551 ],
    "parents" : [ ],
    "children" : [ 10217620, 10217602 ]
  }, {
    "dbId" : 10205302,
    "stId" : "R-RNO-8953721",
    "displayName" : "Phb2 [mitochondrial inner membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48895,
    "identifier" : "Q5XIH7",
    "standardIdentifier" : "uniprot:Q5XIH7",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Phb2" ],
    "parents" : [ 10217613 ],
    "children" : [ ]
  }, {
    "dbId" : 10217620,
    "stId" : "R-RNO-9840382",
    "displayName" : "EIF2AK1 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48895,
    "diagramIds" : [ 115550 ],
    "identifier" : "Q63185",
    "standardIdentifier" : "uniprot:Q63185",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10217622 ],
    "children" : [ ]
  }, {
    "dbId" : 10217610,
    "stId" : "R-RNO-9840535",
    "displayName" : "OMA1(144-447):Zn2+ [mitochondrial inner membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48895,
    "diagramIds" : [ 115540 ],
    "parents" : [ ],
    "children" : [ 8949653, 10217608 ]
  }, {
    "dbId" : 10205354,
    "stId" : "R-RNO-8949651",
    "displayName" : "YME1L1:Zn2+ [mitochondrial inner membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48895,
    "parents" : [ 10217638 ],
    "children" : [ 8949653, 10205352 ]
  }, {
    "dbId" : 10217608,
    "stId" : "R-RNO-9840539",
    "displayName" : "OMA1(144-447) [mitochondrial inner membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48895,
    "identifier" : "D3ZS74",
    "standardIdentifier" : "uniprot:D3ZS74",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10217610 ],
    "children" : [ ]
  }, {
    "dbId" : 10205352,
    "stId" : "R-RNO-8949648",
    "displayName" : "YME1L1 [mitochondrial inner membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48895,
    "identifier" : "Q925S8",
    "standardIdentifier" : "uniprot:Q925S8",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10205354 ],
    "children" : [ ]
  }, {
    "dbId" : 5696069,
    "stId" : "R-ALL-5696069",
    "displayName" : "ATP [mitochondrial intermembrane space]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "diagramIds" : [ 115541 ],
    "identifier" : "30616",
    "standardIdentifier" : "chebi:30616",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10106542,
    "stId" : "R-RNO-72515",
    "displayName" : "EIF2S1:EIF2S2:EIF2S3 [cytosol]",
    "schemaClass" : "Complex",
    "speciesId" : 48895,
    "diagramIds" : [ 115553 ],
    "parents" : [ ],
    "children" : [ 10106533, 10106529, 10106540 ]
  }, {
    "dbId" : 10106540,
    "stId" : "R-RNO-72514",
    "displayName" : "EIF2S3 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48895,
    "identifier" : "P81795",
    "standardIdentifier" : "uniprot:P81795",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10133816, 10106542 ],
    "children" : [ ]
  }, {
    "dbId" : 10217613,
    "stId" : "R-RNO-9840657",
    "displayName" : "PHB2:STOML2 [mitochondrial inner membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48895,
    "diagramIds" : [ 115546 ],
    "parents" : [ ],
    "children" : [ 10205302, 10205347 ]
  }, {
    "dbId" : 10205347,
    "stId" : "R-RNO-8953739",
    "displayName" : "Stoml2 [mitochondrial inner membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48895,
    "identifier" : "Q4FZT0",
    "standardIdentifier" : "uniprot:Q4FZT0",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Stoml2" ],
    "parents" : [ 10217613 ],
    "children" : [ ]
  }, {
    "dbId" : 10217602,
    "stId" : "R-RNO-9840380",
    "displayName" : "Dele1 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48895,
    "diagramIds" : [ 115548 ],
    "identifier" : "P60924",
    "standardIdentifier" : "uniprot:P60924",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Dele1" ],
    "parents" : [ 10217622 ],
    "children" : [ ]
  }, {
    "dbId" : 10106529,
    "stId" : "R-RNO-72510",
    "displayName" : "Eif2s1 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48895,
    "identifier" : "P68101",
    "standardIdentifier" : "uniprot:P68101",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Eif2s1" ],
    "parents" : [ 10106542 ],
    "children" : [ ]
  }, {
    "dbId" : 10217600,
    "stId" : "R-RNO-9840386",
    "displayName" : "Dele1 [mitochondrial inner membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48895,
    "diagramIds" : [ 115545 ],
    "identifier" : "P60924",
    "standardIdentifier" : "uniprot:P60924",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Dele1" ],
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 8949653,
    "stId" : "R-ALL-8949653",
    "displayName" : "Zn2+ [mitochondrial inner membrane]",
    "schemaClass" : "SimpleEntity",
    "speciesId" : 0,
    "identifier" : "29105",
    "standardIdentifier" : "chebi:29105",
    "referenceType" : "ReferenceMolecule",
    "parents" : [ 10217610, 10205354 ],
    "children" : [ ]
  }, {
    "dbId" : 10217638,
    "stId" : "R-RNO-9839129",
    "displayName" : "YME1L1:Zn2+ hexamer [mitochondrial inner membrane]",
    "schemaClass" : "Complex",
    "speciesId" : 48895,
    "diagramIds" : [ 115538 ],
    "parents" : [ ],
    "children" : [ 10205354 ]
  }, {
    "dbId" : 10217606,
    "stId" : "R-RNO-9840377",
    "displayName" : "Dele1 [mitochondrial inner membrane]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48895,
    "diagramIds" : [ 115544 ],
    "identifier" : "P60924",
    "standardIdentifier" : "uniprot:P60924",
    "referenceType" : "ReferenceGeneProduct",
    "geneNames" : [ "Dele1" ],
    "parents" : [ ],
    "children" : [ ]
  }, {
    "dbId" : 10106533,
    "stId" : "R-RNO-72512",
    "displayName" : "EIF2S2 [cytosol]",
    "schemaClass" : "EntityWithAccessionedSequence",
    "speciesId" : 48895,
    "identifier" : "Q6P685",
    "standardIdentifier" : "uniprot:Q6P685",
    "referenceType" : "ReferenceGeneProduct",
    "parents" : [ 10133816, 10106542 ],
    "children" : [ ]
  } ],
  "edges" : [ {
    "dbId" : 10217627,
    "stId" : "R-RNO-9840429",
    "displayName" : "DELE1(143-515) binds EIF2AK1 (HRI)",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "preceding" : [ 10217604 ],
    "following" : [ 10217624 ],
    "inputs" : [ 10217620, 10217602 ],
    "outputs" : [ 10217622 ],
    "efs" : [ ],
    "diagramIds" : [ 115549 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10217640,
    "stId" : "R-RNO-9840564",
    "displayName" : "OMA1 hydrolyzes YME1L1",
    "schemaClass" : "BlackBoxEvent",
    "speciesId" : 0,
    "inputs" : [ 10217638 ],
    "outputs" : [ 3777117 ],
    "catalysts" : [ 10217610 ],
    "efs" : [ ],
    "inhibitors" : [ 5696069 ],
    "diagramIds" : [ 115537 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10217624,
    "stId" : "R-RNO-9840415",
    "displayName" : "DELE1(143-515):EIF2AK1 enhances phosphorylation of EIF2S1 (EIF2alpha)",
    "schemaClass" : "BlackBoxEvent",
    "speciesId" : 0,
    "preceding" : [ 10217627 ],
    "inputs" : [ 10106542 ],
    "outputs" : [ 10133816 ],
    "efs" : [ ],
    "activators" : [ 10217622 ],
    "diagramIds" : [ 115552 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10217615,
    "stId" : "R-RNO-9840408",
    "displayName" : "OMA1 cleaves DELE1",
    "schemaClass" : "Reaction",
    "speciesId" : 0,
    "following" : [ 10217604 ],
    "inputs" : [ 10217606, 189422 ],
    "outputs" : [ 10217600 ],
    "catalysts" : [ 10217610 ],
    "efs" : [ ],
    "inhibitors" : [ 10217613 ],
    "diagramIds" : [ 115542 ],
    "entityFunctionalStatus" : [ ]
  }, {
    "dbId" : 10217604,
    "stId" : "R-RNO-9840401",
    "displayName" : "DELE1(143-515) is released into the cytosol",
    "schemaClass" : "BlackBoxEvent",
    "speciesId" : 0,
    "preceding" : [ 10217615 ],
    "following" : [ 10217627 ],
    "inputs" : [ 10217600 ],
    "outputs" : [ 10217602 ],
    "efs" : [ ],
    "diagramIds" : [ 115547 ],
    "entityFunctionalStatus" : [ ]
  } ]
}