{
  "dbId" : 10222835,
  "stableId" : "R-RNO-975871",
  "displayName" : "MyD88 cascade initiated on plasma membrane",
  "nodes" : [ {
    "id" : 54344,
    "reactomeId" : 10222847,
    "displayName" : "MAP kinase activation",
    "schemaClass" : "Pathway",
    "renderableClass" : "ProcessNode",
    "position" : {
      "x" : 837,
      "y" : 590
    },
    "minX" : 763,
    "maxX" : 911,
    "minY" : 538,
    "maxY" : 643,
    "prop" : {
      "x" : 763,
      "y" : 538,
      "width" : 148,
      "height" : 105
    },
    "textPosition" : {
      "x" : 791,
      "y" : 569
    },
    "connectors" : [ ]
  }, {
    "id" : 54345,
    "reactomeId" : 10222875,
    "displayName" : "TAK1-dependent IKK and NF-kappa-B activation",
    "schemaClass" : "Pathway",
    "renderableClass" : "ProcessNode",
    "position" : {
      "x" : 837,
      "y" : 433
    },
    "minX" : 746,
    "maxX" : 928,
    "minY" : 385,
    "maxY" : 482,
    "prop" : {
      "x" : 746,
      "y" : 385,
      "width" : 182,
      "height" : 97
    },
    "textPosition" : {
      "x" : 751,
      "y" : 412
    },
    "connectors" : [ ]
  }, {
    "id" : 54294,
    "reactomeId" : 10117103,
    "displayName" : "MAP3K1",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1208,
      "y" : 635
    },
    "minX" : 1177,
    "maxX" : 1255,
    "minY" : 620,
    "maxY" : 671,
    "prop" : {
      "x" : 1177,
      "y" : 626,
      "width" : 62,
      "height" : 19
    },
    "textPosition" : {
      "x" : 1179,
      "y" : 625
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1239,
          "y" : 626
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1239,
          "y" : 626
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 54293,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1220,
          "y" : 648
        },
        "to" : {
          "x" : 1255,
          "y" : 671
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 54295,
    "reactomeId" : 10117110,
    "displayName" : "Traf6",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1316,
      "y" : 638
    },
    "minX" : 1255,
    "maxX" : 1349,
    "minY" : 621,
    "maxY" : 671,
    "prop" : {
      "x" : 1290,
      "y" : 627,
      "width" : 53,
      "height" : 22
    },
    "textPosition" : {
      "x" : 1296,
      "y" : 627
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1343,
          "y" : 627
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1343,
          "y" : 627
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 54293,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1295,
          "y" : 652
        },
        "to" : {
          "x" : 1255,
          "y" : 671
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 54296,
    "reactomeId" : 10117112,
    "displayName" : "MEKK1:activated TRAF6",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1261,
      "y" : 775
    },
    "minX" : 1204,
    "maxX" : 1324,
    "minY" : 752,
    "maxY" : 793,
    "prop" : {
      "x" : 1204,
      "y" : 758,
      "width" : 114,
      "height" : 35
    },
    "textPosition" : {
      "x" : 1204,
      "y" : 758
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1318,
          "y" : 758
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1318,
          "y" : 758
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 54293,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 54297,
    "reactomeId" : 10117117,
    "displayName" : "Ecsit",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1192,
      "y" : 704
    },
    "minX" : 1167,
    "maxX" : 1247,
    "minY" : 688,
    "maxY" : 715,
    "prop" : {
      "x" : 1167,
      "y" : 694,
      "width" : 50,
      "height" : 21
    },
    "textPosition" : {
      "x" : 1173,
      "y" : 694
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1217,
          "y" : 694
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1217,
          "y" : 694
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 54293,
      "type" : "ACTIVATOR",
      "segments" : [ {
        "from" : {
          "x" : 1220,
          "y" : 705
        },
        "to" : {
          "x" : 1247,
          "y" : 707
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1240,
          "y" : 710
        },
        "b" : {
          "x" : 1247,
          "y" : 707
        },
        "c" : {
          "x" : 1240,
          "y" : 702
        },
        "type" : "ARROW",
        "empty" : true,
        "centre" : {
          "x" : 1240,
          "y" : 702
        }
      }
    } ]
  }, {
    "id" : 54299,
    "reactomeId" : 10146204,
    "displayName" : "TRAF6:hp-IRAK1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1640,
      "y" : 1005
    },
    "minX" : 1586,
    "maxX" : 1739,
    "minY" : 137,
    "maxY" : 1016,
    "prop" : {
      "x" : 1586,
      "y" : 995,
      "width" : 108,
      "height" : 21
    },
    "textPosition" : {
      "x" : 1588,
      "y" : 995
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1694,
          "y" : 995
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1694,
          "y" : 995
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 54298,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1697,
          "y" : 1005
        },
        "to" : {
          "x" : 1739,
          "y" : 1005
        }
      }, {
        "from" : {
          "x" : 1739,
          "y" : 1005
        },
        "to" : {
          "x" : 1739,
          "y" : 181
        }
      }, {
        "from" : {
          "x" : 1739,
          "y" : 181
        },
        "to" : {
          "x" : 1617,
          "y" : 137
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 54300,
    "reactomeId" : 10141927,
    "displayName" : "p-Pellino-1,2,(3)",
    "schemaClass" : "CandidateSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1537,
      "y" : 186
    },
    "minX" : 1483,
    "maxX" : 1617,
    "minY" : 137,
    "maxY" : 197,
    "prop" : {
      "x" : 1483,
      "y" : 176,
      "width" : 109,
      "height" : 21
    },
    "textPosition" : {
      "x" : 1484,
      "y" : 176
    },
    "connectors" : [ {
      "edgeId" : 54298,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1554,
          "y" : 170
        },
        "to" : {
          "x" : 1617,
          "y" : 137
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 54301,
    "reactomeId" : 10146206,
    "displayName" : "TRAF6:hp-IRAK1:Pellino",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1568,
      "y" : 31
    },
    "minX" : 1461,
    "maxX" : 1630,
    "minY" : 8,
    "maxY" : 76,
    "prop" : {
      "x" : 1513,
      "y" : 14,
      "width" : 111,
      "height" : 35
    },
    "textPosition" : {
      "x" : 1514,
      "y" : 14
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1624,
          "y" : 14
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1624,
          "y" : 14
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 54298,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 54302,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1541,
          "y" : 52
        },
        "to" : {
          "x" : 1500,
          "y" : 76
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 54302,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 1510,
          "y" : 43
        },
        "to" : {
          "x" : 1468,
          "y" : 54
        }
      }, {
        "from" : {
          "x" : 1468,
          "y" : 54
        },
        "to" : {
          "x" : 1466,
          "y" : 61
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1465,
          "y" : 64
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1465,
          "y" : 64
        }
      }
    } ]
  }, {
    "id" : 54303,
    "reactomeId" : 113592,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1532,
      "y" : 113
    },
    "minX" : 1500,
    "maxX" : 1553,
    "minY" : 76,
    "maxY" : 128,
    "prop" : {
      "x" : 1513,
      "y" : 99,
      "width" : 39,
      "height" : 29
    },
    "textPosition" : {
      "x" : 1517,
      "y" : 103
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1547,
          "y" : 104
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1547,
          "y" : 104
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 54302,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1519,
          "y" : 96
        },
        "to" : {
          "x" : 1500,
          "y" : 76
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 54304,
    "reactomeId" : 29370,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1406,
      "y" : 116
    },
    "minX" : 1386,
    "maxX" : 1428,
    "minY" : 101,
    "maxY" : 131,
    "prop" : {
      "x" : 1386,
      "y" : 102,
      "width" : 41,
      "height" : 29
    },
    "textPosition" : {
      "x" : 1390,
      "y" : 106
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1422,
          "y" : 107
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1422,
          "y" : 107
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 54302,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 54306,
    "reactomeId" : 10117453,
    "displayName" : "K63polyUb",
    "schemaClass" : "Polymer",
    "renderableClass" : "Entity",
    "position" : {
      "x" : 1397,
      "y" : 165
    },
    "minX" : 1300,
    "maxX" : 1456,
    "minY" : 71,
    "maxY" : 176,
    "prop" : {
      "x" : 1338,
      "y" : 155,
      "width" : 118,
      "height" : 21
    },
    "textPosition" : {
      "x" : 1360,
      "y" : 155
    },
    "connectors" : [ {
      "edgeId" : 54305,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1386,
          "y" : 152
        },
        "to" : {
          "x" : 1300,
          "y" : 71
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 1337,
            "y" : 105
          },
          "b" : {
            "x" : 1349,
            "y" : 117
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1343,
            "y" : 111
          }
        }
      }
    } ]
  }, {
    "id" : 54307,
    "reactomeId" : 10146206,
    "displayName" : "TRAF6:hp-IRAK1:Pellino",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1378,
      "y" : 30
    },
    "minX" : 1267,
    "maxX" : 1429,
    "minY" : 7,
    "maxY" : 71,
    "prop" : {
      "x" : 1333,
      "y" : 13,
      "width" : 90,
      "height" : 35
    },
    "textPosition" : {
      "x" : 1334,
      "y" : 13
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1423,
          "y" : 13
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1423,
          "y" : 13
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 54305,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1344,
          "y" : 51
        },
        "to" : {
          "x" : 1300,
          "y" : 71
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 54305,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 1330,
          "y" : 30
        },
        "to" : {
          "x" : 1279,
          "y" : 32
        }
      }, {
        "from" : {
          "x" : 1279,
          "y" : 32
        },
        "to" : {
          "x" : 1273,
          "y" : 54
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1271,
          "y" : 57
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1271,
          "y" : 57
        }
      }
    } ]
  }, {
    "id" : 54308,
    "reactomeId" : 10117489,
    "displayName" : "UBE2N:UBE2V1",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1261,
      "y" : 168
    },
    "minX" : 1212,
    "maxX" : 1314,
    "minY" : 71,
    "maxY" : 186,
    "prop" : {
      "x" : 1214,
      "y" : 151,
      "width" : 94,
      "height" : 35
    },
    "textPosition" : {
      "x" : 1232,
      "y" : 151
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1308,
          "y" : 151
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1308,
          "y" : 151
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 54305,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1268,
          "y" : 148
        },
        "to" : {
          "x" : 1300,
          "y" : 71
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 54305,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1252,
          "y" : 148
        },
        "to" : {
          "x" : 1212,
          "y" : 72
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1245,
          "y" : 144
        },
        "b" : {
          "x" : 1252,
          "y" : 148
        },
        "c" : {
          "x" : 1252,
          "y" : 140
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1252,
          "y" : 140
        }
      }
    } ]
  }, {
    "id" : 54309,
    "reactomeId" : 10146196,
    "displayName" : "K63-linked polyUb p-IRAK1:TRAF6",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1078,
      "y" : 23
    },
    "minX" : 1007,
    "maxX" : 1212,
    "minY" : 0,
    "maxY" : 104,
    "prop" : {
      "x" : 1016,
      "y" : 6,
      "width" : 125,
      "height" : 35
    },
    "textPosition" : {
      "x" : 1017,
      "y" : 6
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1141,
          "y" : 6
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1141,
          "y" : 6
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 54305,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1125,
          "y" : 44
        },
        "to" : {
          "x" : 1212,
          "y" : 72
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1133,
          "y" : 42
        },
        "b" : {
          "x" : 1125,
          "y" : 44
        },
        "c" : {
          "x" : 1130,
          "y" : 50
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1130,
          "y" : 50
        }
      }
    }, {
      "edgeId" : 54311,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1062,
          "y" : 44
        },
        "to" : {
          "x" : 1007,
          "y" : 104
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 54310,
    "reactomeId" : 10141927,
    "displayName" : "p-Pellino-1,2,(3)",
    "schemaClass" : "CandidateSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1124,
      "y" : 166
    },
    "minX" : 1070,
    "maxX" : 1212,
    "minY" : 72,
    "maxY" : 177,
    "prop" : {
      "x" : 1070,
      "y" : 156,
      "width" : 109,
      "height" : 21
    },
    "textPosition" : {
      "x" : 1071,
      "y" : 156
    },
    "connectors" : [ {
      "edgeId" : 54305,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1133,
          "y" : 150
        },
        "to" : {
          "x" : 1212,
          "y" : 72
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1135,
          "y" : 142
        },
        "b" : {
          "x" : 1133,
          "y" : 150
        },
        "c" : {
          "x" : 1141,
          "y" : 148
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1141,
          "y" : 148
        }
      }
    } ]
  }, {
    "id" : 54312,
    "reactomeId" : 10125739,
    "displayName" : "CHUK:IKBKB:IKBKG",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1076,
      "y" : 111
    },
    "minX" : 1007,
    "maxX" : 1123,
    "minY" : 89,
    "maxY" : 128,
    "prop" : {
      "x" : 1036,
      "y" : 95,
      "width" : 81,
      "height" : 33
    },
    "textPosition" : {
      "x" : 1037,
      "y" : 93
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1117,
          "y" : 95
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1117,
          "y" : 95
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 54311,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1033,
          "y" : 106
        },
        "to" : {
          "x" : 1007,
          "y" : 104
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 54313,
    "reactomeId" : 10146198,
    "displayName" : "TRAF6:K63-linked polyUb p-IRAK1:IKK complex",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 836,
      "y" : 37
    },
    "minX" : 770,
    "maxX" : 909,
    "minY" : 7,
    "maxY" : 62,
    "prop" : {
      "x" : 770,
      "y" : 13,
      "width" : 133,
      "height" : 49
    },
    "textPosition" : {
      "x" : 774,
      "y" : 13
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 903,
          "y" : 13
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 903,
          "y" : 13
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 54311,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 54315,
    "reactomeId" : 10146151,
    "displayName" : "TRAF6:p-IRAK2",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1636,
      "y" : 889
    },
    "minX" : 1586,
    "maxX" : 1692,
    "minY" : 853,
    "maxY" : 900,
    "prop" : {
      "x" : 1586,
      "y" : 879,
      "width" : 100,
      "height" : 21
    },
    "textPosition" : {
      "x" : 1588,
      "y" : 879
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1686,
          "y" : 879
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1686,
          "y" : 879
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 54314,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1622,
          "y" : 876
        },
        "to" : {
          "x" : 1589,
          "y" : 853
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 54316,
    "reactomeId" : 10117110,
    "displayName" : "Traf6",
    "schemaClass" : "EntityWithAccessionedSequence",
    "renderableClass" : "Protein",
    "position" : {
      "x" : 1523,
      "y" : 891
    },
    "minX" : 1497,
    "maxX" : 1589,
    "minY" : 853,
    "maxY" : 902,
    "prop" : {
      "x" : 1497,
      "y" : 880,
      "width" : 53,
      "height" : 22
    },
    "textPosition" : {
      "x" : 1503,
      "y" : 880
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1550,
          "y" : 880
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1550,
          "y" : 880
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 54314,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1542,
          "y" : 877
        },
        "to" : {
          "x" : 1589,
          "y" : 853
        }
      } ],
      "stoichiometry" : {
        "value" : 2,
        "shape" : {
          "a" : {
            "x" : 1559,
            "y" : 859
          },
          "b" : {
            "x" : 1571,
            "y" : 871
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1565,
            "y" : 865
          }
        }
      }
    } ]
  }, {
    "id" : 54317,
    "reactomeId" : 10146153,
    "displayName" : "p-IRAK2:oligo-TRAF6",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1631,
      "y" : 748
    },
    "minX" : 1570,
    "maxX" : 1687,
    "minY" : 664,
    "maxY" : 766,
    "prop" : {
      "x" : 1581,
      "y" : 731,
      "width" : 100,
      "height" : 35
    },
    "textPosition" : {
      "x" : 1585,
      "y" : 731
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1681,
          "y" : 731
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1681,
          "y" : 731
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 54314,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 54318,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1605,
          "y" : 728
        },
        "to" : {
          "x" : 1570,
          "y" : 706
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 54318,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 1625,
          "y" : 728
        },
        "to" : {
          "x" : 1606,
          "y" : 673
        }
      }, {
        "from" : {
          "x" : 1606,
          "y" : 673
        },
        "to" : {
          "x" : 1587,
          "y" : 669
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1583,
          "y" : 668
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1583,
          "y" : 668
        }
      }
    } ]
  }, {
    "id" : 54319,
    "reactomeId" : 10103388,
    "displayName" : "Ub",
    "schemaClass" : "DefinedSet",
    "renderableClass" : "EntitySet",
    "position" : {
      "x" : 1478,
      "y" : 763
    },
    "minX" : 1439,
    "maxX" : 1570,
    "minY" : 706,
    "maxY" : 775,
    "prop" : {
      "x" : 1439,
      "y" : 751,
      "width" : 79,
      "height" : 24
    },
    "textPosition" : {
      "x" : 1466,
      "y" : 752
    },
    "connectors" : [ {
      "edgeId" : 54329,
      "type" : "INPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 54318,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1497,
          "y" : 745
        },
        "to" : {
          "x" : 1570,
          "y" : 706
        }
      } ],
      "stoichiometry" : {
        "value" : 9,
        "shape" : {
          "a" : {
            "x" : 1527,
            "y" : 719
          },
          "b" : {
            "x" : 1539,
            "y" : 731
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1533,
            "y" : 725
          }
        }
      }
    } ]
  }, {
    "id" : 54320,
    "reactomeId" : 10146158,
    "displayName" : "p-IRAK2:K63-linked pUb oligo-TRAF6",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1632,
      "y" : 602
    },
    "minX" : 1485,
    "maxX" : 1695,
    "minY" : 539,
    "maxY" : 682,
    "prop" : {
      "x" : 1575,
      "y" : 578,
      "width" : 114,
      "height" : 49
    },
    "textPosition" : {
      "x" : 1576,
      "y" : 578
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1689,
          "y" : 578
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1689,
          "y" : 578
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 54321,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1616,
          "y" : 575
        },
        "to" : {
          "x" : 1592,
          "y" : 539
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 54329,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 1585,
          "y" : 630
        },
        "to" : {
          "x" : 1492,
          "y" : 676
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1489,
          "y" : 678
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1489,
          "y" : 678
        }
      }
    }, {
      "edgeId" : 54318,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 54322,
    "reactomeId" : 10140908,
    "displayName" : "TAK1 complex",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1459,
      "y" : 561
    },
    "minX" : 1412,
    "maxX" : 1592,
    "minY" : 539,
    "maxY" : 572,
    "prop" : {
      "x" : 1412,
      "y" : 551,
      "width" : 95,
      "height" : 21
    },
    "textPosition" : {
      "x" : 1413,
      "y" : 551
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1507,
          "y" : 551
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1507,
          "y" : 551
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 54321,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1510,
          "y" : 553
        },
        "to" : {
          "x" : 1592,
          "y" : 539
        }
      } ],
      "stoichiometry" : {
        "value" : 3,
        "shape" : {
          "a" : {
            "x" : 1545,
            "y" : 540
          },
          "b" : {
            "x" : 1557,
            "y" : 552
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1551,
            "y" : 546
          }
        }
      }
    } ]
  }, {
    "id" : 54323,
    "reactomeId" : 10117453,
    "displayName" : "K63polyUb",
    "schemaClass" : "Polymer",
    "renderableClass" : "Entity",
    "position" : {
      "x" : 1479,
      "y" : 614
    },
    "minX" : 1420,
    "maxX" : 1592,
    "minY" : 539,
    "maxY" : 625,
    "prop" : {
      "x" : 1420,
      "y" : 604,
      "width" : 118,
      "height" : 21
    },
    "textPosition" : {
      "x" : 1442,
      "y" : 604
    },
    "connectors" : [ {
      "edgeId" : 54321,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1494,
          "y" : 601
        },
        "to" : {
          "x" : 1592,
          "y" : 539
        }
      } ],
      "stoichiometry" : {
        "value" : 3,
        "shape" : {
          "a" : {
            "x" : 1537,
            "y" : 564
          },
          "b" : {
            "x" : 1549,
            "y" : 576
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1543,
            "y" : 570
          }
        }
      }
    }, {
      "edgeId" : 54329,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    } ]
  }, {
    "id" : 54324,
    "reactomeId" : 10146176,
    "displayName" : "p-IRAK2:K63-linked pUb oligo-TRAF6:free K63 pUb:TAK1 complex",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1655,
      "y" : 453
    },
    "minX" : 1561,
    "maxX" : 1723,
    "minY" : 382,
    "maxY" : 485,
    "prop" : {
      "x" : 1594,
      "y" : 422,
      "width" : 123,
      "height" : 63
    },
    "textPosition" : {
      "x" : 1592,
      "y" : 422
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1717,
          "y" : 422
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1717,
          "y" : 422
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 54321,
      "type" : "OUTPUT",
      "segments" : [ ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 54325,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1591,
          "y" : 430
        },
        "to" : {
          "x" : 1561,
          "y" : 418
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      }
    }, {
      "edgeId" : 54325,
      "type" : "CATALYST",
      "segments" : [ {
        "from" : {
          "x" : 1621,
          "y" : 419
        },
        "to" : {
          "x" : 1582,
          "y" : 385
        }
      }, {
        "from" : {
          "x" : 1582,
          "y" : 385
        },
        "to" : {
          "x" : 1576,
          "y" : 386
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "c" : {
          "x" : 1572,
          "y" : 386
        },
        "r" : 4,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1572,
          "y" : 386
        }
      }
    } ]
  }, {
    "id" : 54326,
    "reactomeId" : 113592,
    "displayName" : "ATP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1517,
      "y" : 462
    },
    "minX" : 1498,
    "maxX" : 1561,
    "minY" : 418,
    "maxY" : 477,
    "prop" : {
      "x" : 1498,
      "y" : 448,
      "width" : 39,
      "height" : 29
    },
    "textPosition" : {
      "x" : 1502,
      "y" : 452
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1532,
          "y" : 453
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1532,
          "y" : 453
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 54325,
      "type" : "INPUT",
      "segments" : [ {
        "from" : {
          "x" : 1531,
          "y" : 445
        },
        "to" : {
          "x" : 1561,
          "y" : 418
        }
      } ],
      "stoichiometry" : {
        "value" : 6,
        "shape" : {
          "a" : {
            "x" : 1540,
            "y" : 425
          },
          "b" : {
            "x" : 1552,
            "y" : 437
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1546,
            "y" : 431
          }
        }
      }
    } ]
  }, {
    "id" : 54327,
    "reactomeId" : 10146187,
    "displayName" : "p-IRAK2:K63-linked pUb oligo-TRAF6:free K63-linked pUb:p-TAK1complex",
    "schemaClass" : "Complex",
    "renderableClass" : "Complex",
    "position" : {
      "x" : 1626,
      "y" : 269
    },
    "minX" : 1559,
    "maxX" : 1689,
    "minY" : 225,
    "maxY" : 358,
    "prop" : {
      "x" : 1569,
      "y" : 231,
      "width" : 114,
      "height" : 77
    },
    "textPosition" : {
      "x" : 1570,
      "y" : 231
    },
    "bgColor" : {
      "r" : 204,
      "g" : 255,
      "b" : 255
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1683,
          "y" : 231
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1683,
          "y" : 231
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 54325,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1597,
          "y" : 311
        },
        "to" : {
          "x" : 1559,
          "y" : 358
        }
      } ],
      "stoichiometry" : {
        "value" : 1
      },
      "endShape" : {
        "a" : {
          "x" : 1596,
          "y" : 319
        },
        "b" : {
          "x" : 1597,
          "y" : 311
        },
        "c" : {
          "x" : 1590,
          "y" : 314
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1590,
          "y" : 314
        }
      }
    } ]
  }, {
    "id" : 54328,
    "reactomeId" : 29370,
    "displayName" : "ADP",
    "schemaClass" : "SimpleEntity",
    "renderableClass" : "Chemical",
    "position" : {
      "x" : 1502,
      "y" : 331
    },
    "minX" : 1482,
    "maxX" : 1559,
    "minY" : 316,
    "maxY" : 358,
    "prop" : {
      "x" : 1482,
      "y" : 317,
      "width" : 41,
      "height" : 29
    },
    "textPosition" : {
      "x" : 1486,
      "y" : 321
    },
    "interactorsSummary" : {
      "type" : "TR",
      "shape" : {
        "c" : {
          "x" : 1518,
          "y" : 322
        },
        "r" : 6,
        "type" : "CIRCLE",
        "empty" : true,
        "centre" : {
          "x" : 1518,
          "y" : 322
        }
      }
    },
    "connectors" : [ {
      "edgeId" : 54325,
      "type" : "OUTPUT",
      "segments" : [ {
        "from" : {
          "x" : 1526,
          "y" : 340
        },
        "to" : {
          "x" : 1559,
          "y" : 358
        }
      } ],
      "stoichiometry" : {
        "value" : 6,
        "shape" : {
          "a" : {
            "x" : 1536,
            "y" : 343
          },
          "b" : {
            "x" : 1548,
            "y" : 355
          },
          "type" : "BOX",
          "empty" : true,
          "centre" : {
            "x" : 1542,
            "y" : 349
          }
        }
      },
      "endShape" : {
        "a" : {
          "x" : 1534,
          "y" : 340
        },
        "b" : {
          "x" : 1526,
          "y" : 340
        },
        "c" : {
          "x" : 1530,
          "y" : 347
        },
        "type" : "ARROW",
        "centre" : {
          "x" : 1530,
          "y" : 347
        }
      }
    } ]
  } ],
  "edges" : [ {
    "id" : 54321,
    "reactomeId" : 10146178,
    "displayName" : "Activated TRAF6:p-IRAK2 interacts with TAK1 complex",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1592,
      "y" : 508
    },
    "minX" : 1586,
    "maxX" : 1618,
    "minY" : 488,
    "maxY" : 539,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 1592,
        "y" : 539
      },
      "to" : {
        "x" : 1592,
        "y" : 508
      }
    }, {
      "from" : {
        "x" : 1592,
        "y" : 508
      },
      "to" : {
        "x" : 1618,
        "y" : 488
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1615,
        "y" : 495
      },
      "b" : {
        "x" : 1618,
        "y" : 488
      },
      "c" : {
        "x" : 1610,
        "y" : 489
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1610,
        "y" : 489
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1592,
        "y" : 508
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1592,
        "y" : 508
      }
    },
    "inputs" : [ {
      "id" : 54322,
      "points" : [ {
        "x" : 1510,
        "y" : 553
      } ],
      "stoichiometry" : 3
    }, {
      "id" : 54320,
      "points" : [ {
        "x" : 1616,
        "y" : 575
      } ]
    }, {
      "id" : 54323,
      "points" : [ {
        "x" : 1494,
        "y" : 601
      } ],
      "stoichiometry" : 3
    } ],
    "outputs" : [ {
      "id" : 54324
    } ]
  }, {
    "id" : 54305,
    "reactomeId" : 10146214,
    "displayName" : "Pellino ubiquitinates hp-IRAK1",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1268,
      "y" : 69
    },
    "minX" : 1212,
    "maxX" : 1300,
    "minY" : 63,
    "maxY" : 75,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1300,
        "y" : 71
      },
      "to" : {
        "x" : 1268,
        "y" : 69
      }
    }, {
      "from" : {
        "x" : 1268,
        "y" : 69
      },
      "to" : {
        "x" : 1212,
        "y" : 72
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1262,
        "y" : 63
      },
      "b" : {
        "x" : 1274,
        "y" : 75
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1268,
        "y" : 69
      }
    },
    "inputs" : [ {
      "id" : 54306,
      "points" : [ {
        "x" : 1386,
        "y" : 152
      } ],
      "stoichiometry" : 2
    }, {
      "id" : 54307,
      "points" : [ {
        "x" : 1344,
        "y" : 51
      } ]
    }, {
      "id" : 54308,
      "points" : [ {
        "x" : 1268,
        "y" : 148
      } ]
    } ],
    "outputs" : [ {
      "id" : 54309,
      "points" : [ {
        "x" : 1125,
        "y" : 44
      } ]
    }, {
      "id" : 54308,
      "points" : [ {
        "x" : 1252,
        "y" : 148
      } ]
    }, {
      "id" : 54310,
      "points" : [ {
        "x" : 1133,
        "y" : 150
      } ]
    } ],
    "catalysts" : [ {
      "id" : 54307,
      "points" : [ {
        "x" : 1330,
        "y" : 30
      }, {
        "x" : 1279,
        "y" : 32
      } ]
    } ]
  }, {
    "id" : 54325,
    "reactomeId" : 10146190,
    "displayName" : "Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1560,
      "y" : 388
    },
    "minX" : 1554,
    "maxX" : 1566,
    "minY" : 358,
    "maxY" : 418,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1561,
        "y" : 418
      },
      "to" : {
        "x" : 1560,
        "y" : 388
      }
    }, {
      "from" : {
        "x" : 1560,
        "y" : 388
      },
      "to" : {
        "x" : 1559,
        "y" : 358
      }
    } ],
    "reactionShape" : {
      "a" : {
        "x" : 1554,
        "y" : 382
      },
      "b" : {
        "x" : 1566,
        "y" : 394
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1560,
        "y" : 388
      }
    },
    "inputs" : [ {
      "id" : 54324,
      "points" : [ {
        "x" : 1591,
        "y" : 430
      } ]
    }, {
      "id" : 54326,
      "points" : [ {
        "x" : 1531,
        "y" : 445
      } ],
      "stoichiometry" : 6
    } ],
    "outputs" : [ {
      "id" : 54327,
      "points" : [ {
        "x" : 1597,
        "y" : 311
      } ]
    }, {
      "id" : 54328,
      "points" : [ {
        "x" : 1526,
        "y" : 340
      } ],
      "stoichiometry" : 6
    } ],
    "catalysts" : [ {
      "id" : 54324,
      "points" : [ {
        "x" : 1621,
        "y" : 419
      }, {
        "x" : 1582,
        "y" : 385
      } ]
    } ]
  }, {
    "id" : 54293,
    "reactomeId" : 10117119,
    "displayName" : "TRAF6 binds MEKK1",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1256,
      "y" : 707
    },
    "minX" : 1250,
    "maxX" : 1262,
    "minY" : 671,
    "maxY" : 755,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 1255,
        "y" : 671
      },
      "to" : {
        "x" : 1256,
        "y" : 707
      }
    }, {
      "from" : {
        "x" : 1256,
        "y" : 707
      },
      "to" : {
        "x" : 1259,
        "y" : 755
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1255,
        "y" : 748
      },
      "b" : {
        "x" : 1259,
        "y" : 755
      },
      "c" : {
        "x" : 1263,
        "y" : 748
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1263,
        "y" : 748
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1256,
        "y" : 707
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1256,
        "y" : 707
      }
    },
    "inputs" : [ {
      "id" : 54294,
      "points" : [ {
        "x" : 1220,
        "y" : 648
      } ]
    }, {
      "id" : 54295,
      "points" : [ {
        "x" : 1295,
        "y" : 652
      } ]
    } ],
    "outputs" : [ {
      "id" : 54296
    } ],
    "activators" : [ {
      "id" : 54297,
      "points" : [ {
        "x" : 1220,
        "y" : 705
      } ]
    } ]
  }, {
    "id" : 54311,
    "reactomeId" : 10146200,
    "displayName" : "NEMO subunit of IKK complex binds to activated IRAK1",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 937,
      "y" : 104
    },
    "minX" : 872,
    "maxX" : 1007,
    "minY" : 65,
    "maxY" : 110,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 1007,
        "y" : 104
      },
      "to" : {
        "x" : 937,
        "y" : 104
      }
    }, {
      "from" : {
        "x" : 937,
        "y" : 104
      },
      "to" : {
        "x" : 872,
        "y" : 65
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 880,
        "y" : 65
      },
      "b" : {
        "x" : 872,
        "y" : 65
      },
      "c" : {
        "x" : 876,
        "y" : 72
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 876,
        "y" : 72
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 937,
        "y" : 104
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 937,
        "y" : 104
      }
    },
    "inputs" : [ {
      "id" : 54309,
      "points" : [ {
        "x" : 1062,
        "y" : 44
      } ]
    }, {
      "id" : 54312,
      "points" : [ {
        "x" : 1033,
        "y" : 106
      } ]
    } ],
    "outputs" : [ {
      "id" : 54313
    } ]
  }, {
    "id" : 54329,
    "reactomeId" : 10146185,
    "displayName" : "Activated TRAF6 synthesizes unanchored polyubiquitin chains",
    "schemaClass" : "Polymerisation",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1478,
      "y" : 683
    },
    "minX" : 1472,
    "maxX" : 1484,
    "minY" : 628,
    "maxY" : 745,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 1478,
        "y" : 745
      },
      "to" : {
        "x" : 1478,
        "y" : 683
      }
    }, {
      "from" : {
        "x" : 1478,
        "y" : 683
      },
      "to" : {
        "x" : 1478,
        "y" : 628
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1482,
        "y" : 635
      },
      "b" : {
        "x" : 1478,
        "y" : 628
      },
      "c" : {
        "x" : 1474,
        "y" : 635
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1474,
        "y" : 635
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1478,
        "y" : 683
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1478,
        "y" : 683
      }
    },
    "inputs" : [ {
      "id" : 54319
    } ],
    "outputs" : [ {
      "id" : 54323
    } ],
    "catalysts" : [ {
      "id" : 54320,
      "points" : [ {
        "x" : 1585,
        "y" : 630
      } ]
    } ]
  }, {
    "id" : 54298,
    "reactomeId" : 10146211,
    "displayName" : "Pellino binds hp-IRAK1:TRAF6",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1603,
      "y" : 84
    },
    "minX" : 1579,
    "maxX" : 1617,
    "minY" : 52,
    "maxY" : 137,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 1617,
        "y" : 137
      },
      "to" : {
        "x" : 1603,
        "y" : 84
      }
    }, {
      "from" : {
        "x" : 1603,
        "y" : 84
      },
      "to" : {
        "x" : 1579,
        "y" : 52
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1586,
        "y" : 55
      },
      "b" : {
        "x" : 1579,
        "y" : 52
      },
      "c" : {
        "x" : 1580,
        "y" : 60
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1580,
        "y" : 60
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1603,
        "y" : 84
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1603,
        "y" : 84
      }
    },
    "inputs" : [ {
      "id" : 54299,
      "points" : [ {
        "x" : 1697,
        "y" : 1005
      }, {
        "x" : 1739,
        "y" : 1005
      }, {
        "x" : 1739,
        "y" : 181
      } ]
    }, {
      "id" : 54300,
      "points" : [ {
        "x" : 1554,
        "y" : 170
      } ]
    } ],
    "outputs" : [ {
      "id" : 54301
    } ]
  }, {
    "id" : 54314,
    "reactomeId" : 10146180,
    "displayName" : "IRAK2 induces TRAF6 oligomerization",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1589,
      "y" : 809
    },
    "minX" : 1583,
    "maxX" : 1618,
    "minY" : 769,
    "maxY" : 853,
    "reactionType" : "binding",
    "segments" : [ {
      "from" : {
        "x" : 1589,
        "y" : 853
      },
      "to" : {
        "x" : 1589,
        "y" : 809
      }
    }, {
      "from" : {
        "x" : 1589,
        "y" : 809
      },
      "to" : {
        "x" : 1618,
        "y" : 769
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1617,
        "y" : 777
      },
      "b" : {
        "x" : 1618,
        "y" : 769
      },
      "c" : {
        "x" : 1611,
        "y" : 772
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1611,
        "y" : 772
      }
    },
    "reactionShape" : {
      "c" : {
        "x" : 1589,
        "y" : 809
      },
      "r" : 5,
      "type" : "CIRCLE",
      "centre" : {
        "x" : 1589,
        "y" : 809
      }
    },
    "inputs" : [ {
      "id" : 54315,
      "points" : [ {
        "x" : 1622,
        "y" : 876
      } ]
    }, {
      "id" : 54316,
      "points" : [ {
        "x" : 1542,
        "y" : 877
      } ],
      "stoichiometry" : 2
    } ],
    "outputs" : [ {
      "id" : 54317
    } ]
  }, {
    "id" : 54318,
    "reactomeId" : 10146161,
    "displayName" : "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2",
    "schemaClass" : "BlackBoxEvent",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1571,
      "y" : 665
    },
    "minX" : 1565,
    "maxX" : 1608,
    "minY" : 630,
    "maxY" : 706,
    "reactionType" : "omitted",
    "segments" : [ {
      "from" : {
        "x" : 1570,
        "y" : 706
      },
      "to" : {
        "x" : 1571,
        "y" : 665
      }
    }, {
      "from" : {
        "x" : 1571,
        "y" : 665
      },
      "to" : {
        "x" : 1608,
        "y" : 630
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1606,
        "y" : 638
      },
      "b" : {
        "x" : 1608,
        "y" : 630
      },
      "c" : {
        "x" : 1600,
        "y" : 632
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1600,
        "y" : 632
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 1565,
        "y" : 659
      },
      "b" : {
        "x" : 1577,
        "y" : 671
      },
      "s" : "\\\\",
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1571,
        "y" : 665
      }
    },
    "inputs" : [ {
      "id" : 54317,
      "points" : [ {
        "x" : 1605,
        "y" : 728
      } ]
    }, {
      "id" : 54319,
      "points" : [ {
        "x" : 1497,
        "y" : 745
      } ],
      "stoichiometry" : 9
    } ],
    "outputs" : [ {
      "id" : 54320
    } ],
    "catalysts" : [ {
      "id" : 54317,
      "points" : [ {
        "x" : 1625,
        "y" : 728
      }, {
        "x" : 1606,
        "y" : 673
      } ]
    } ]
  }, {
    "id" : 54302,
    "reactomeId" : 10146209,
    "displayName" : "IRAK1 phosphorylates Pellino",
    "schemaClass" : "Reaction",
    "renderableClass" : "Reaction",
    "position" : {
      "x" : 1462,
      "y" : 76
    },
    "minX" : 1426,
    "maxX" : 1500,
    "minY" : 70,
    "maxY" : 99,
    "reactionType" : "transition",
    "segments" : [ {
      "from" : {
        "x" : 1500,
        "y" : 76
      },
      "to" : {
        "x" : 1462,
        "y" : 76
      }
    }, {
      "from" : {
        "x" : 1462,
        "y" : 76
      },
      "to" : {
        "x" : 1426,
        "y" : 99
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 1430,
        "y" : 92
      },
      "b" : {
        "x" : 1426,
        "y" : 99
      },
      "c" : {
        "x" : 1434,
        "y" : 99
      },
      "type" : "ARROW",
      "centre" : {
        "x" : 1434,
        "y" : 99
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 1456,
        "y" : 70
      },
      "b" : {
        "x" : 1468,
        "y" : 82
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1462,
        "y" : 76
      }
    },
    "inputs" : [ {
      "id" : 54301,
      "points" : [ {
        "x" : 1541,
        "y" : 52
      } ]
    }, {
      "id" : 54303,
      "points" : [ {
        "x" : 1519,
        "y" : 96
      } ]
    } ],
    "outputs" : [ {
      "id" : 54304
    } ],
    "catalysts" : [ {
      "id" : 54301,
      "points" : [ {
        "x" : 1510,
        "y" : 43
      }, {
        "x" : 1468,
        "y" : 54
      } ]
    } ]
  } ],
  "compartments" : [ {
    "id" : 54330,
    "reactomeId" : 70101,
    "displayName" : "cytosol",
    "schemaClass" : "Compartment",
    "renderableClass" : "Compartment",
    "position" : {
      "x" : 814,
      "y" : 573
    },
    "minX" : 0,
    "maxX" : 1629,
    "minY" : 38,
    "maxY" : 1109,
    "prop" : {
      "x" : 0,
      "y" : 38,
      "width" : 1629,
      "height" : 1071
    },
    "textPosition" : {
      "x" : 462,
      "y" : 617
    },
    "insets" : {
      "x" : 10,
      "y" : 48,
      "width" : 1609,
      "height" : 1051
    },
    "bgColor" : {
      "r" : 250,
      "g" : 240,
      "b" : 240
    },
    "componentIds" : [ 54295, 54293, 54294, 54296, 54297, 54344, 54345, 54301, 54307, 54309, 54313, 54299, 54300, 54303, 54304, 54308, 54306, 54312, 54302, 54305, 54311, 54310, 54317, 54314, 54315, 54316, 54318, 54320, 54319, 54329, 54323, 54321, 54324, 54322, 54327, 54325, 54328, 54326, 54346, 54347, 54348, 54298 ]
  } ],
  "notes" : [ ],
  "links" : [ {
    "id" : 54346,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 866,
      "y" : 330
    },
    "minX" : 850,
    "maxX" : 1566,
    "minY" : 273,
    "maxY" : 382,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 1566,
        "y" : 273
      },
      "to" : {
        "x" : 866,
        "y" : 330
      }
    }, {
      "from" : {
        "x" : 866,
        "y" : 330
      },
      "to" : {
        "x" : 850,
        "y" : 382
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 848,
        "y" : 374
      },
      "b" : {
        "x" : 850,
        "y" : 382
      },
      "c" : {
        "x" : 856,
        "y" : 377
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 856,
        "y" : 377
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 860,
        "y" : 324
      },
      "b" : {
        "x" : 872,
        "y" : 336
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 866,
        "y" : 330
      }
    },
    "inputs" : [ {
      "id" : 54327
    } ],
    "outputs" : [ {
      "id" : 54345
    } ]
  }, {
    "id" : 54347,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 1458,
      "y" : 304
    },
    "minX" : 914,
    "maxX" : 1566,
    "minY" : 280,
    "maxY" : 555,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 1566,
        "y" : 280
      },
      "to" : {
        "x" : 1458,
        "y" : 304
      }
    }, {
      "from" : {
        "x" : 1458,
        "y" : 304
      },
      "to" : {
        "x" : 914,
        "y" : 555
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 919,
        "y" : 548
      },
      "b" : {
        "x" : 914,
        "y" : 555
      },
      "c" : {
        "x" : 922,
        "y" : 556
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 922,
        "y" : 556
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 1452,
        "y" : 298
      },
      "b" : {
        "x" : 1464,
        "y" : 310
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 1458,
        "y" : 304
      }
    },
    "inputs" : [ {
      "id" : 54327
    } ],
    "outputs" : [ {
      "id" : 54344
    } ]
  }, {
    "id" : 54348,
    "renderableClass" : "Interaction",
    "position" : {
      "x" : 836,
      "y" : 223
    },
    "minX" : 830,
    "maxX" : 842,
    "minY" : 65,
    "maxY" : 382,
    "interactionType" : "Activate",
    "segments" : [ {
      "from" : {
        "x" : 836,
        "y" : 65
      },
      "to" : {
        "x" : 836,
        "y" : 382
      }
    } ],
    "endShape" : {
      "a" : {
        "x" : 832,
        "y" : 375
      },
      "b" : {
        "x" : 836,
        "y" : 382
      },
      "c" : {
        "x" : 840,
        "y" : 375
      },
      "type" : "ARROW",
      "empty" : true,
      "centre" : {
        "x" : 840,
        "y" : 375
      }
    },
    "reactionShape" : {
      "a" : {
        "x" : 830,
        "y" : 217
      },
      "b" : {
        "x" : 842,
        "y" : 229
      },
      "type" : "BOX",
      "empty" : true,
      "centre" : {
        "x" : 836,
        "y" : 223
      }
    },
    "inputs" : [ {
      "id" : 54313
    } ],
    "outputs" : [ {
      "id" : 54345
    } ]
  } ],
  "shadows" : [ {
    "id" : 54349,
    "reactomeId" : 10224049,
    "displayName" : "IRAK2 mediated activation of TAK1 complex",
    "schemaClass" : "Pathway",
    "renderableClass" : "Shadow",
    "position" : {
      "x" : 1564,
      "y" : 566
    },
    "minX" : 1402,
    "maxX" : 1727,
    "minY" : 221,
    "maxY" : 912,
    "prop" : {
      "x" : 1402,
      "y" : 221,
      "width" : 325,
      "height" : 691
    },
    "points" : [ {
      "x" : 1402,
      "y" : 221
    }, {
      "x" : 1727,
      "y" : 221
    }, {
      "x" : 1727,
      "y" : 912
    }, {
      "x" : 1402,
      "y" : 912
    } ],
    "colour" : "#4684ee"
  }, {
    "id" : 54350,
    "reactomeId" : 10224051,
    "displayName" : "IRAK1 recruits IKK complex",
    "schemaClass" : "Pathway",
    "renderableClass" : "Shadow",
    "position" : {
      "x" : 1232,
      "y" : 511
    },
    "minX" : 760,
    "maxX" : 1704,
    "minY" : -4,
    "maxY" : 1026,
    "prop" : {
      "x" : 760,
      "y" : 221,
      "width" : 642,
      "height" : 691
    },
    "points" : [ {
      "x" : 760,
      "y" : -4
    }, {
      "x" : 1704,
      "y" : -4
    }, {
      "x" : 1704,
      "y" : 1026
    }, {
      "x" : 760,
      "y" : 1026
    } ],
    "colour" : "#dc3912"
  } ],
  "minX" : 0,
  "maxX" : 1739,
  "minY" : 0,
  "maxY" : 1109,
  "disease" : false
}