{ "dbId" : 10225007, "stableId" : "R-RNO-8853659", "displayName" : "RET signaling", "nodes" : [ { "id" : 34048, "reactomeId" : 10198997, "displayName" : "RET:GFRA1,GFRA2", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 164, "y" : 119 }, "minX" : 103, "maxX" : 231, "minY" : 103, "maxY" : 158, "prop" : { "x" : 103, "y" : 109, "width" : 122, "height" : 21 }, "textPosition" : { "x" : 104, "y" : 109 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 225, "y" : 109 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 225, "y" : 109 } } }, "connectors" : [ { "edgeId" : 34117, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 34046, "type" : "INPUT", "segments" : [ { "from" : { "x" : 147, "y" : 133 }, "to" : { "x" : 104, "y" : 158 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 34049, "reactomeId" : 10198999, "displayName" : "RET:GFRA1,GFRA2:GDNF,NRTN", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 161, "y" : 223 }, "minX" : 118, "maxX" : 211, "minY" : 191, "maxY" : 249, "prop" : { "x" : 118, "y" : 197, "width" : 87, "height" : 52 }, "textPosition" : { "x" : 122, "y" : 200 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 205, "y" : 197 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 205, "y" : 197 } } }, "connectors" : [ { "edgeId" : 34046, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 34051, "reactomeId" : 10198981, "displayName" : "RET:GFRA1,GFRA3", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 163, "y" : 311 }, "minX" : 101, "maxX" : 209, "minY" : 286, "maxY" : 349, "prop" : { "x" : 124, "y" : 292, "width" : 79, "height" : 39 }, "textPosition" : { "x" : 124, "y" : 296 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 203, "y" : 292 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 203, "y" : 292 } } }, "connectors" : [ { "edgeId" : 34050, "type" : "INPUT", "segments" : [ { "from" : { "x" : 131, "y" : 334 }, "to" : { "x" : 101, "y" : 349 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 34058, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 34052, "reactomeId" : 10182367, "displayName" : "Artn", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 55, "y" : 317 }, "minX" : 32, "maxX" : 101, "minY" : 300, "maxY" : 349, "prop" : { "x" : 32, "y" : 306, "width" : 47, "height" : 22 }, "textPosition" : { "x" : 38, "y" : 306 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 79, "y" : 306 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 79, "y" : 306 } } }, "connectors" : [ { "edgeId" : 34050, "type" : "INPUT", "segments" : [ { "from" : { "x" : 70, "y" : 331 }, "to" : { "x" : 101, "y" : 349 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 34053, "reactomeId" : 10198995, "displayName" : "RET:GFRA1,GFRA3:ARTN", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 153, "y" : 420 }, "minX" : 97, "maxX" : 215, "minY" : 397, "maxY" : 438, "prop" : { "x" : 97, "y" : 403, "width" : 112, "height" : 35 }, "textPosition" : { "x" : 111, "y" : 403 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 209, "y" : 403 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 209, "y" : 403 } } }, "connectors" : [ { "edgeId" : 34050, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 34055, "reactomeId" : 10199001, "displayName" : "RET:GFRA4", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 159, "y" : 519 }, "minX" : 103, "maxX" : 204, "minY" : 502, "maxY" : 554, "prop" : { "x" : 121, "y" : 508, "width" : 77, "height" : 22 }, "textPosition" : { "x" : 122, "y" : 509 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 198, "y" : 508 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 198, "y" : 508 } } }, "connectors" : [ { "edgeId" : 34054, "type" : "INPUT", "segments" : [ { "from" : { "x" : 141, "y" : 533 }, "to" : { "x" : 103, "y" : 554 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 34119, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 34056, "reactomeId" : 10182419, "displayName" : "Pspn", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 66, "y" : 518 }, "minX" : 48, "maxX" : 103, "minY" : 501, "maxY" : 554, "prop" : { "x" : 48, "y" : 507, "width" : 37, "height" : 22 }, "textPosition" : { "x" : 51, "y" : 501 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 85, "y" : 507 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 85, "y" : 507 } } }, "connectors" : [ { "edgeId" : 34054, "type" : "INPUT", "segments" : [ { "from" : { "x" : 77, "y" : 532 }, "to" : { "x" : 103, "y" : 554 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 34057, "reactomeId" : 10199003, "displayName" : "RET:GFRA4:PSPN", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 153, "y" : 619 }, "minX" : 112, "maxX" : 201, "minY" : 595, "maxY" : 637, "prop" : { "x" : 112, "y" : 601, "width" : 83, "height" : 36 }, "textPosition" : { "x" : 114, "y" : 602 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 195, "y" : 601 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 195, "y" : 601 } } }, "connectors" : [ { "edgeId" : 34054, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 34059, "reactomeId" : 10182379, "displayName" : "GFRA1,GFRA3", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 383, "y" : 64 }, "minX" : 276, "maxX" : 429, "minY" : 53, "maxY" : 97, "prop" : { "x" : 338, "y" : 53, "width" : 91, "height" : 22 }, "textPosition" : { "x" : 357, "y" : 47 }, "connectors" : [ { "edgeId" : 34058, "type" : "INPUT", "segments" : [ { "from" : { "x" : 347, "y" : 81 }, "to" : { "x" : 276, "y" : 97 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 34060, "reactomeId" : 10198979, "displayName" : "RET", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 164, "y" : 70 }, "minX" : 144, "maxX" : 313, "minY" : 54, "maxY" : 130, "prop" : { "x" : 144, "y" : 60, "width" : 40, "height" : 20 }, "textPosition" : { "x" : 148, "y" : 60 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 184, "y" : 60 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 184, "y" : 60 } } }, "connectors" : [ { "edgeId" : 34117, "type" : "INPUT", "segments" : [ { "from" : { "x" : 187, "y" : 76 }, "to" : { "x" : 245, "y" : 96 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 34119, "type" : "INPUT", "segments" : [ { "from" : { "x" : 187, "y" : 78 }, "to" : { "x" : 313, "y" : 130 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 34058, "type" : "INPUT", "segments" : [ { "from" : { "x" : 187, "y" : 74 }, "to" : { "x" : 276, "y" : 97 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 34062, "reactomeId" : 10199005, "displayName" : "RET:GFRA:GDNF complexes", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 607, "y" : 65 }, "minX" : 557, "maxX" : 665, "minY" : 22, "maxY" : 89, "prop" : { "x" : 557, "y" : 42, "width" : 100, "height" : 47 }, "textPosition" : { "x" : 570, "y" : 41 }, "connectors" : [ { "edgeId" : 34061, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 2, "shape" : { "a" : { "x" : 653, "y" : 22 }, "b" : { "x" : 665, "y" : 34 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 659, "y" : 28 } } } } ] }, { "id" : 34063, "reactomeId" : 10199007, "displayName" : "2x RET:GFRA:GDNF complexes", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 737, "y" : 68 }, "minX" : 314, "maxX" : 833, "minY" : 44, "maxY" : 582, "prop" : { "x" : 679, "y" : 50, "width" : 117, "height" : 36 }, "textPosition" : { "x" : 681, "y" : 51 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 796, "y" : 50 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 796, "y" : 50 } } }, "connectors" : [ { "edgeId" : 34061, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 34064, "type" : "INPUT", "segments" : [ { "from" : { "x" : 782, "y" : 89 }, "to" : { "x" : 807, "y" : 96 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 34064, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 799, "y" : 59 }, "to" : { "x" : 829, "y" : 55 } }, { "from" : { "x" : 829, "y" : 55 }, "to" : { "x" : 829, "y" : 81 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 829, "y" : 85 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 829, "y" : 85 } } }, { "edgeId" : 34068, "type" : "INPUT", "segments" : [ { "from" : { "x" : 722, "y" : 89 }, "to" : { "x" : 314, "y" : 582 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 34065, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 773, "y" : 137 }, "minX" : 754, "maxX" : 807, "minY" : 96, "maxY" : 152, "prop" : { "x" : 754, "y" : 122, "width" : 38, "height" : 30 }, "textPosition" : { "x" : 757, "y" : 126 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 787, "y" : 127 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 787, "y" : 127 } } }, "connectors" : [ { "edgeId" : 34064, "type" : "INPUT", "segments" : [ { "from" : { "x" : 785, "y" : 119 }, "to" : { "x" : 807, "y" : 96 } } ], "stoichiometry" : { "value" : 30, "shape" : { "a" : { "x" : 790, "y" : 101 }, "b" : { "x" : 802, "y" : 113 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 796, "y" : 107 } } } } ] }, { "id" : 34066, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 882, "y" : 138 }, "minX" : 854, "maxX" : 903, "minY" : 96, "maxY" : 153, "prop" : { "x" : 862, "y" : 123, "width" : 40, "height" : 30 }, "textPosition" : { "x" : 865, "y" : 127 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 897, "y" : 128 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 897, "y" : 128 } } }, "connectors" : [ { "edgeId" : 34064, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 872, "y" : 120 }, "to" : { "x" : 854, "y" : 96 } } ], "stoichiometry" : { "value" : 30, "shape" : { "a" : { "x" : 857, "y" : 102 }, "b" : { "x" : 869, "y" : 114 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 863, "y" : 108 } } }, "endShape" : { "a" : { "x" : 865, "y" : 117 }, "b" : { "x" : 872, "y" : 120 }, "c" : { "x" : 871, "y" : 112 }, "type" : "ARROW", "centre" : { "x" : 871, "y" : 112 } } } ] }, { "id" : 34067, "reactomeId" : 10182431, "displayName" : "2x p-5Y-RET:GDNF:GFRA complexes", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 934, "y" : 61 }, "minX" : 854, "maxX" : 1841, "minY" : 6, "maxY" : 566, "prop" : { "x" : 881, "y" : 37, "width" : 107, "height" : 49 }, "textPosition" : { "x" : 892, "y" : 37 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 988, "y" : 37 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 988, "y" : 37 } } }, "connectors" : [ { "edgeId" : 34081, "type" : "INPUT", "segments" : [ { "from" : { "x" : 936, "y" : 89 }, "to" : { "x" : 969, "y" : 471 } }, { "from" : { "x" : 969, "y" : 471 }, "to" : { "x" : 1493, "y" : 470 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 34114, "type" : "INPUT", "segments" : [ { "from" : { "x" : 937, "y" : 89 }, "to" : { "x" : 976, "y" : 399 } }, { "from" : { "x" : 976, "y" : 399 }, "to" : { "x" : 1341, "y" : 396 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 34089, "type" : "INPUT", "segments" : [ { "from" : { "x" : 934, "y" : 89 }, "to" : { "x" : 947, "y" : 496 } }, { "from" : { "x" : 947, "y" : 496 }, "to" : { "x" : 1841, "y" : 566 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 34064, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 878, "y" : 84 }, "to" : { "x" : 854, "y" : 96 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 874, "y" : 91 }, "b" : { "x" : 878, "y" : 84 }, "c" : { "x" : 870, "y" : 84 }, "type" : "ARROW", "centre" : { "x" : 870, "y" : 84 } } }, { "edgeId" : 34072, "type" : "INPUT", "segments" : [ { "from" : { "x" : 991, "y" : 70 }, "to" : { "x" : 1063, "y" : 85 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 34075, "type" : "INPUT", "segments" : [ { "from" : { "x" : 975, "y" : 34 }, "to" : { "x" : 1022, "y" : 9 } }, { "from" : { "x" : 1022, "y" : 9 }, "to" : { "x" : 1528, "y" : 6 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 34108, "type" : "INPUT", "segments" : [ { "from" : { "x" : 939, "y" : 89 }, "to" : { "x" : 978, "y" : 242 } }, { "from" : { "x" : 978, "y" : 242 }, "to" : { "x" : 1180, "y" : 242 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 34078, "type" : "INPUT", "segments" : [ { "from" : { "x" : 945, "y" : 89 }, "to" : { "x" : 985, "y" : 167 } }, { "from" : { "x" : 985, "y" : 167 }, "to" : { "x" : 1123, "y" : 168 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 34111, "type" : "INPUT", "segments" : [ { "from" : { "x" : 938, "y" : 89 }, "to" : { "x" : 986, "y" : 318 } }, { "from" : { "x" : 986, "y" : 318 }, "to" : { "x" : 1248, "y" : 318 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 34069, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 276, "y" : 557 }, "minX" : 257, "maxX" : 314, "minY" : 541, "maxY" : 582, "prop" : { "x" : 257, "y" : 542, "width" : 38, "height" : 30 }, "textPosition" : { "x" : 260, "y" : 546 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 290, "y" : 547 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 290, "y" : 547 } } }, "connectors" : [ { "edgeId" : 34068, "type" : "INPUT", "segments" : [ { "from" : { "x" : 298, "y" : 569 }, "to" : { "x" : 314, "y" : 582 } } ], "stoichiometry" : { "value" : 6, "shape" : { "a" : { "x" : 300, "y" : 569 }, "b" : { "x" : 312, "y" : 581 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 306, "y" : 575 } } } } ] }, { "id" : 34070, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 265, "y" : 687 }, "minX" : 245, "maxX" : 286, "minY" : 671, "maxY" : 702, "prop" : { "x" : 245, "y" : 672, "width" : 40, "height" : 30 }, "textPosition" : { "x" : 248, "y" : 676 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 280, "y" : 677 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 280, "y" : 677 } } }, "connectors" : [ { "edgeId" : 34068, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 34071, "reactomeId" : 10175370, "displayName" : "Protein kinase A catalytic subunit", "schemaClass" : "CandidateSet", "renderableClass" : "EntitySet", "position" : { "x" : 396, "y" : 619 }, "minX" : 322, "maxX" : 435, "minY" : 589, "maxY" : 649, "prop" : { "x" : 357, "y" : 589, "width" : 78, "height" : 60 }, "textPosition" : { "x" : 363, "y" : 588 }, "connectors" : [ { "edgeId" : 34068, "type" : "CATALYST", "segments" : [ { "from" : { "x" : 351, "y" : 618 }, "to" : { "x" : 330, "y" : 618 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "c" : { "x" : 326, "y" : 618 }, "r" : 4, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 326, "y" : 618 } } } ] }, { "id" : 34073, "reactomeId" : 10199488, "displayName" : "RET interactors", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1038, "y" : 126 }, "minX" : 988, "maxX" : 1089, "minY" : 85, "maxY" : 139, "prop" : { "x" : 988, "y" : 113, "width" : 101, "height" : 26 }, "textPosition" : { "x" : 1000, "y" : 109 }, "connectors" : [ { "edgeId" : 34072, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1045, "y" : 107 }, "to" : { "x" : 1063, "y" : 85 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 34074, "reactomeId" : 10199490, "displayName" : "2x p-5Y-RET:GDNF:GFRA complexes:RET interactors", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1184, "y" : 64 }, "minX" : 1119, "maxX" : 1255, "minY" : 33, "maxY" : 89, "prop" : { "x" : 1119, "y" : 39, "width" : 130, "height" : 50 }, "textPosition" : { "x" : 1123, "y" : 40 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1249, "y" : 39 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1249, "y" : 39 } } }, "connectors" : [ { "edgeId" : 34072, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 34076, "reactomeId" : 10180750, "displayName" : "Frs2", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1480, "y" : 69 }, "minX" : 1459, "maxX" : 1528, "minY" : 6, "maxY" : 81, "prop" : { "x" : 1459, "y" : 58, "width" : 43, "height" : 23 }, "textPosition" : { "x" : 1463, "y" : 59 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1502, "y" : 58 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1502, "y" : 58 } } }, "connectors" : [ { "edgeId" : 34075, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1488, "y" : 55 }, "to" : { "x" : 1528, "y" : 6 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 34077, "reactomeId" : 10199400, "displayName" : "2x p-5Y-RET:GDNF:GFRA complexes:FRS2", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1630, "y" : 69 }, "minX" : 1572, "maxX" : 1695, "minY" : 38, "maxY" : 94, "prop" : { "x" : 1572, "y" : 44, "width" : 117, "height" : 50 }, "textPosition" : { "x" : 1576, "y" : 45 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1689, "y" : 44 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1689, "y" : 44 } } }, "connectors" : [ { "edgeId" : 34075, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 34079, "reactomeId" : 10199416, "displayName" : "DOK1,DOK2,DOK4,DOK5,DOK6", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1097, "y" : 202 }, "minX" : 1036, "maxX" : 1158, "minY" : 168, "maxY" : 221, "prop" : { "x" : 1036, "y" : 184, "width" : 122, "height" : 37 }, "textPosition" : { "x" : 1037, "y" : 185 }, "connectors" : [ { "edgeId" : 34078, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1111, "y" : 178 }, "to" : { "x" : 1123, "y" : 168 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 34080, "reactomeId" : 10199418, "displayName" : "2x p-5Y-RET:GDNF:GFRA complexes:DOK1,DOK2,DOK4,DOK5,DOK6", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1349, "y" : 67 }, "minX" : 1284, "maxX" : 1421, "minY" : 29, "maxY" : 100, "prop" : { "x" : 1284, "y" : 35, "width" : 131, "height" : 65 }, "textPosition" : { "x" : 1288, "y" : 37 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1415, "y" : 35 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1415, "y" : 35 } } }, "connectors" : [ { "edgeId" : 34078, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 34082, "reactomeId" : 10108630, "displayName" : "Shc1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1437, "y" : 503 }, "minX" : 1416, "maxX" : 1493, "minY" : 470, "maxY" : 514, "prop" : { "x" : 1416, "y" : 492, "width" : 43, "height" : 22 }, "textPosition" : { "x" : 1418, "y" : 492 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1459, "y" : 492 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1459, "y" : 492 } } }, "connectors" : [ { "edgeId" : 34081, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1455, "y" : 489 }, "to" : { "x" : 1493, "y" : 470 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 34083, "reactomeId" : 10198975, "displayName" : "2x p-5Y-RET:GDNF:GFRA complexes:SHC1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2250, "y" : 240 }, "minX" : 2192, "maxX" : 2315, "minY" : 209, "maxY" : 265, "prop" : { "x" : 2192, "y" : 215, "width" : 117, "height" : 50 }, "textPosition" : { "x" : 2195, "y" : 216 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2309, "y" : 215 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2309, "y" : 215 } } }, "connectors" : [ { "edgeId" : 34081, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 34084, "type" : "INPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 34085, "reactomeId" : 10182433, "displayName" : "2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2249, "y" : 395 }, "minX" : 2183, "maxX" : 2322, "minY" : 354, "maxY" : 481, "prop" : { "x" : 2183, "y" : 360, "width" : 133, "height" : 70 }, "textPosition" : { "x" : 2186, "y" : 367 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2316, "y" : 360 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2316, "y" : 360 } } }, "connectors" : [ { "edgeId" : 34084, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 34086, "type" : "INPUT", "segments" : [ { "from" : { "x" : 2231, "y" : 433 }, "to" : { "x" : 2205, "y" : 481 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 34087, "reactomeId" : 10108599, "displayName" : "GRB2-1:SOS1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1903, "y" : 499 }, "minX" : 1841, "maxX" : 2205, "minY" : 481, "maxY" : 566, "prop" : { "x" : 1856, "y" : 488, "width" : 94, "height" : 22 }, "textPosition" : { "x" : 1858, "y" : 489 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1950, "y" : 488 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1950, "y" : 488 } } }, "connectors" : [ { "edgeId" : 34086, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1953, "y" : 496 }, "to" : { "x" : 2205, "y" : 481 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 34089, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1892, "y" : 513 }, "to" : { "x" : 1841, "y" : 566 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 34088, "reactomeId" : 10182435, "displayName" : "2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1:SOS1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2241, "y" : 590 }, "minX" : 2169, "maxX" : 2319, "minY" : 551, "maxY" : 624, "prop" : { "x" : 2169, "y" : 557, "width" : 144, "height" : 67 }, "textPosition" : { "x" : 2177, "y" : 561 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2313, "y" : 557 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2313, "y" : 557 } } }, "connectors" : [ { "edgeId" : 34086, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 34090, "reactomeId" : 10182437, "displayName" : "2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1:SOS1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2247, "y" : 677 }, "minX" : 2183, "maxX" : 2317, "minY" : 643, "maxY" : 705, "prop" : { "x" : 2183, "y" : 649, "width" : 128, "height" : 56 }, "textPosition" : { "x" : 2186, "y" : 656 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2311, "y" : 649 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2311, "y" : 649 } } }, "connectors" : [ { "edgeId" : 34089, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 34092, "reactomeId" : 10108594, "displayName" : "Grb2", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 518, "y" : 607 }, "minX" : 489, "maxX" : 553, "minY" : 590, "maxY" : 658, "prop" : { "x" : 489, "y" : 596, "width" : 58, "height" : 22 }, "textPosition" : { "x" : 499, "y" : 596 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 547, "y" : 596 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 547, "y" : 596 } } }, "connectors" : [ { "edgeId" : 34091, "type" : "INPUT", "segments" : [ { "from" : { "x" : 525, "y" : 621 }, "to" : { "x" : 553, "y" : 658 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 34093, "reactomeId" : 10199036, "displayName" : "p-5Y-RET:GDNF:GFRA complexes with and without p-SHC1", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 492, "y" : 720 }, "minX" : 425, "maxX" : 559, "minY" : 658, "maxY" : 745, "prop" : { "x" : 425, "y" : 695, "width" : 134, "height" : 50 }, "textPosition" : { "x" : 428, "y" : 689 }, "connectors" : [ { "edgeId" : 34091, "type" : "INPUT", "segments" : [ { "from" : { "x" : 516, "y" : 689 }, "to" : { "x" : 553, "y" : 658 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 34094, "reactomeId" : 10199015, "displayName" : "2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 656, "y" : 718 }, "minX" : 591, "maxX" : 721, "minY" : 651, "maxY" : 750, "prop" : { "x" : 591, "y" : 686, "width" : 130, "height" : 64 }, "textPosition" : { "x" : 595, "y" : 686 }, "connectors" : [ { "edgeId" : 34091, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 34095, "type" : "INPUT", "segments" : [ { "from" : { "x" : 680, "y" : 680 }, "to" : { "x" : 707, "y" : 651 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 34096, "reactomeId" : 10199017, "displayName" : "GAB1,GAB2", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 656, "y" : 612 }, "minX" : 613, "maxX" : 707, "minY" : 602, "maxY" : 651, "prop" : { "x" : 613, "y" : 602, "width" : 87, "height" : 21 }, "textPosition" : { "x" : 617, "y" : 602 }, "connectors" : [ { "edgeId" : 34095, "type" : "INPUT", "segments" : [ { "from" : { "x" : 669, "y" : 629 }, "to" : { "x" : 707, "y" : 651 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 34097, "reactomeId" : 10199019, "displayName" : "2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:GAB1,GAB2", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 824, "y" : 717 }, "minX" : 754, "maxX" : 900, "minY" : 654, "maxY" : 749, "prop" : { "x" : 754, "y" : 685, "width" : 140, "height" : 64 }, "textPosition" : { "x" : 754, "y" : 686 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 894, "y" : 685 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 894, "y" : 685 } } }, "connectors" : [ { "edgeId" : 34095, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 34098, "type" : "INPUT", "segments" : [ { "from" : { "x" : 849, "y" : 682 }, "to" : { "x" : 875, "y" : 654 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 34099, "reactomeId" : 113592, "displayName" : "ATP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 824, "y" : 607 }, "minX" : 805, "maxX" : 875, "minY" : 591, "maxY" : 654, "prop" : { "x" : 805, "y" : 592, "width" : 38, "height" : 30 }, "textPosition" : { "x" : 808, "y" : 596 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 838, "y" : 597 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 838, "y" : 597 } } }, "connectors" : [ { "edgeId" : 34098, "type" : "INPUT", "segments" : [ { "from" : { "x" : 840, "y" : 625 }, "to" : { "x" : 875, "y" : 654 } } ], "stoichiometry" : { "value" : 5, "shape" : { "a" : { "x" : 851, "y" : 633 }, "b" : { "x" : 863, "y" : 645 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 857, "y" : 639 } } } } ] }, { "id" : 34100, "reactomeId" : 10199027, "displayName" : "2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 984, "y" : 714 }, "minX" : 915, "maxX" : 1513, "minY" : 615, "maxY" : 752, "prop" : { "x" : 915, "y" : 676, "width" : 138, "height" : 76 }, "textPosition" : { "x" : 921, "y" : 675 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1053, "y" : 676 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1053, "y" : 676 } } }, "connectors" : [ { "edgeId" : 34098, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 942, "y" : 673 }, "to" : { "x" : 919, "y" : 654 } } ], "stoichiometry" : { "value" : 1 }, "endShape" : { "a" : { "x" : 934, "y" : 672 }, "b" : { "x" : 942, "y" : 673 }, "c" : { "x" : 939, "y" : 666 }, "type" : "ARROW", "centre" : { "x" : 939, "y" : 666 } } }, { "edgeId" : 34102, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1056, "y" : 713 }, "to" : { "x" : 1144, "y" : 712 } } ], "stoichiometry" : { "value" : 1 } }, { "edgeId" : 34105, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1014, "y" : 673 }, "to" : { "x" : 1064, "y" : 615 } }, { "from" : { "x" : 1064, "y" : 615 }, "to" : { "x" : 1513, "y" : 617 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 34101, "reactomeId" : 29370, "displayName" : "ADP", "schemaClass" : "SimpleEntity", "renderableClass" : "Chemical", "position" : { "x" : 989, "y" : 606 }, "minX" : 919, "maxX" : 1010, "minY" : 590, "maxY" : 654, "prop" : { "x" : 969, "y" : 591, "width" : 40, "height" : 30 }, "textPosition" : { "x" : 972, "y" : 595 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1004, "y" : 596 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1004, "y" : 596 } } }, "connectors" : [ { "edgeId" : 34098, "type" : "OUTPUT", "segments" : [ { "from" : { "x" : 966, "y" : 619 }, "to" : { "x" : 919, "y" : 654 } } ], "stoichiometry" : { "value" : 5, "shape" : { "a" : { "x" : 936, "y" : 630 }, "b" : { "x" : 948, "y" : 642 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 942, "y" : 636 } } }, "endShape" : { "a" : { "x" : 963, "y" : 626 }, "b" : { "x" : 966, "y" : 619 }, "c" : { "x" : 958, "y" : 620 }, "type" : "ARROW", "centre" : { "x" : 958, "y" : 620 } } } ] }, { "id" : 34103, "reactomeId" : 10143211, "displayName" : "p85-containing Class 1A PI3Ks", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1126, "y" : 661 }, "minX" : 1060, "maxX" : 1192, "minY" : 643, "maxY" : 712, "prop" : { "x" : 1060, "y" : 643, "width" : 132, "height" : 36 }, "textPosition" : { "x" : 1073, "y" : 643 }, "connectors" : [ { "edgeId" : 34102, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1132, "y" : 685 }, "to" : { "x" : 1144, "y" : 712 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 34104, "reactomeId" : 10199324, "displayName" : "2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2:p85-containing Class 1A PI3Ks", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1321, "y" : 717 }, "minX" : 1248, "maxX" : 1400, "minY" : 664, "maxY" : 765, "prop" : { "x" : 1248, "y" : 670, "width" : 146, "height" : 95 }, "textPosition" : { "x" : 1248, "y" : 674 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1394, "y" : 670 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1394, "y" : 670 } } }, "connectors" : [ { "edgeId" : 34102, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 34106, "reactomeId" : 10116968, "displayName" : "PTPN11", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1460, "y" : 581 }, "minX" : 1432, "maxX" : 1513, "minY" : 564, "maxY" : 617, "prop" : { "x" : 1432, "y" : 570, "width" : 57, "height" : 23 }, "textPosition" : { "x" : 1432, "y" : 571 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1489, "y" : 570 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1489, "y" : 570 } } }, "connectors" : [ { "edgeId" : 34105, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1476, "y" : 596 }, "to" : { "x" : 1513, "y" : 617 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 34107, "reactomeId" : 10199396, "displayName" : "2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2:PTPN11", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1639, "y" : 716 }, "minX" : 1568, "maxX" : 1716, "minY" : 671, "maxY" : 755, "prop" : { "x" : 1568, "y" : 677, "width" : 142, "height" : 78 }, "textPosition" : { "x" : 1569, "y" : 678 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1710, "y" : 677 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1710, "y" : 677 } } }, "connectors" : [ { "edgeId" : 34105, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 34109, "reactomeId" : 10198985, "displayName" : "GRB7,GRB10", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1151, "y" : 284 }, "minX" : 1108, "maxX" : 1194, "minY" : 242, "maxY" : 299, "prop" : { "x" : 1108, "y" : 270, "width" : 86, "height" : 29 }, "textPosition" : { "x" : 1108, "y" : 274 }, "connectors" : [ { "edgeId" : 34108, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1161, "y" : 264 }, "to" : { "x" : 1180, "y" : 242 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 34110, "reactomeId" : 10198987, "displayName" : "2x p-5Y-RET:GDNF:GFRA complexes:GRB7,GRB10", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1802, "y" : 69 }, "minX" : 1742, "maxX" : 1869, "minY" : 32, "maxY" : 100, "prop" : { "x" : 1742, "y" : 38, "width" : 121, "height" : 62 }, "textPosition" : { "x" : 1745, "y" : 37 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1863, "y" : 38 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1863, "y" : 38 } } }, "connectors" : [ { "edgeId" : 34108, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 34112, "reactomeId" : 10125512, "displayName" : "PLCG1", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 1210, "y" : 360 }, "minX" : 1184, "maxX" : 1248, "minY" : 318, "maxY" : 372, "prop" : { "x" : 1184, "y" : 349, "width" : 53, "height" : 23 }, "textPosition" : { "x" : 1187, "y" : 350 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 1237, "y" : 349 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 1237, "y" : 349 } } }, "connectors" : [ { "edgeId" : 34111, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1220, "y" : 346 }, "to" : { "x" : 1248, "y" : 318 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 34113, "reactomeId" : 10198991, "displayName" : "2x p-5Y-RET:GDNF:GFRA complexes:PLCG1", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 1994, "y" : 74 }, "minX" : 1936, "maxX" : 2059, "minY" : 43, "maxY" : 99, "prop" : { "x" : 1936, "y" : 49, "width" : 117, "height" : 50 }, "textPosition" : { "x" : 1936, "y" : 50 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2053, "y" : 49 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2053, "y" : 49 } } }, "connectors" : [ { "edgeId" : 34111, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 34115, "reactomeId" : 10199449, "displayName" : "SRC-1, RAP1GAP", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 1256, "y" : 437 }, "minX" : 1200, "maxX" : 1341, "minY" : 396, "maxY" : 448, "prop" : { "x" : 1200, "y" : 426, "width" : 112, "height" : 22 }, "textPosition" : { "x" : 1201, "y" : 426 }, "connectors" : [ { "edgeId" : 34114, "type" : "INPUT", "segments" : [ { "from" : { "x" : 1278, "y" : 420 }, "to" : { "x" : 1341, "y" : 396 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 34116, "reactomeId" : 10199451, "displayName" : "2x p-5Y-RET:GDNF:GFRA complexes:SRC-1,RAP1GAP", "schemaClass" : "Complex", "renderableClass" : "Complex", "position" : { "x" : 2159, "y" : 70 }, "minX" : 2101, "maxX" : 2223, "minY" : 33, "maxY" : 101, "prop" : { "x" : 2101, "y" : 39, "width" : 116, "height" : 62 }, "textPosition" : { "x" : 2106, "y" : 38 }, "bgColor" : { "r" : 204, "g" : 255, "b" : 255 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 2217, "y" : 39 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 2217, "y" : 39 } } }, "connectors" : [ { "edgeId" : 34114, "type" : "OUTPUT", "segments" : [ ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 34118, "reactomeId" : 10182406, "displayName" : "GFRA1, GFRA2", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 274, "y" : 65 }, "minX" : 227, "maxX" : 322, "minY" : 54, "maxY" : 96, "prop" : { "x" : 227, "y" : 54, "width" : 95, "height" : 22 }, "textPosition" : { "x" : 246, "y" : 48 }, "connectors" : [ { "edgeId" : 34117, "type" : "INPUT", "segments" : [ { "from" : { "x" : 263, "y" : 82 }, "to" : { "x" : 245, "y" : 96 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 34120, "reactomeId" : 10182423, "displayName" : "Gfra4", "schemaClass" : "EntityWithAccessionedSequence", "renderableClass" : "Protein", "position" : { "x" : 485, "y" : 65 }, "minX" : 313, "maxX" : 515, "minY" : 48, "maxY" : 130, "prop" : { "x" : 461, "y" : 54, "width" : 48, "height" : 22 }, "textPosition" : { "x" : 464, "y" : 54 }, "interactorsSummary" : { "type" : "TR", "shape" : { "c" : { "x" : 509, "y" : 54 }, "r" : 6, "type" : "CIRCLE", "empty" : true, "centre" : { "x" : 509, "y" : 54 } } }, "connectors" : [ { "edgeId" : 34119, "type" : "INPUT", "segments" : [ { "from" : { "x" : 458, "y" : 74 }, "to" : { "x" : 313, "y" : 130 } } ], "stoichiometry" : { "value" : 1 } } ] }, { "id" : 34123, "reactomeId" : 10224791, "displayName" : "RAF/MAP kinase cascade", "schemaClass" : "Pathway", "renderableClass" : "EncapsulatedNode", "position" : { "x" : 2019, "y" : 600 }, "minX" : 1956, "maxX" : 2082, "minY" : 571, "maxY" : 630, "prop" : { "x" : 1956, "y" : 571, "width" : 126, "height" : 59 }, "textPosition" : { "x" : 1960, "y" : 579 }, "connectors" : [ ] }, { "id" : 34047, "reactomeId" : 10182400, "displayName" : "GDNF,NRTN", "schemaClass" : "DefinedSet", "renderableClass" : "EntitySet", "position" : { "x" : 42, "y" : 118 }, "minX" : 0, "maxX" : 104, "minY" : 107, "maxY" : 158, "prop" : { "x" : 0, "y" : 107, "width" : 84, "height" : 22 }, "textPosition" : { "x" : 2, "y" : 107 }, "connectors" : [ { "edgeId" : 34046, "type" : "INPUT", "segments" : [ { "from" : { "x" : 59, "y" : 135 }, "to" : { "x" : 104, "y" : 158 } } ], "stoichiometry" : { "value" : 1 } } ] } ], "edges" : [ { "id" : 34081, "reactomeId" : 10198977, "displayName" : "2x p-5Y-RET:GDNF:GFRA complexes bind SHC1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1582, "y" : 471 }, "minX" : 1493, "maxX" : 2189, "minY" : 260, "maxY" : 477, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1493, "y" : 470 }, "to" : { "x" : 1582, "y" : 471 } }, { "from" : { "x" : 1582, "y" : 471 }, "to" : { "x" : 2189, "y" : 260 } } ], "endShape" : { "a" : { "x" : 2184, "y" : 266 }, "b" : { "x" : 2189, "y" : 260 }, "c" : { "x" : 2181, "y" : 258 }, "type" : "ARROW", "centre" : { "x" : 2181, "y" : 258 } }, "reactionShape" : { "c" : { "x" : 1582, "y" : 471 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1582, "y" : 471 } }, "inputs" : [ { "id" : 34082, "points" : [ { "x" : 1455, "y" : 489 } ] }, { "id" : 34067, "points" : [ { "x" : 936, "y" : 89 }, { "x" : 969, "y" : 471 } ] } ], "outputs" : [ { "id" : 34083 } ] }, { "id" : 34114, "reactomeId" : 10199453, "displayName" : "2x p-5Y-RET:GDNF:GFRA complexes bind SRC1, RAP1GAP", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1535, "y" : 394 }, "minX" : 1341, "maxX" : 2098, "minY" : 100, "maxY" : 400, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1341, "y" : 396 }, "to" : { "x" : 1535, "y" : 394 } }, { "from" : { "x" : 1535, "y" : 394 }, "to" : { "x" : 2098, "y" : 100 } } ], "endShape" : { "a" : { "x" : 2094, "y" : 107 }, "b" : { "x" : 2098, "y" : 100 }, "c" : { "x" : 2090, "y" : 100 }, "type" : "ARROW", "centre" : { "x" : 2090, "y" : 100 } }, "reactionShape" : { "c" : { "x" : 1535, "y" : 394 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1535, "y" : 394 } }, "inputs" : [ { "id" : 34115, "points" : [ { "x" : 1278, "y" : 420 } ] }, { "id" : 34067, "points" : [ { "x" : 937, "y" : 89 }, { "x" : 976, "y" : 399 } ] } ], "outputs" : [ { "id" : 34116 } ] }, { "id" : 34050, "reactomeId" : 10199040, "displayName" : "ARTN binds RET:GFRA1,GFRA3", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 101, "y" : 372 }, "minX" : 95, "maxX" : 134, "minY" : 349, "maxY" : 400, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 101, "y" : 349 }, "to" : { "x" : 101, "y" : 372 } }, { "from" : { "x" : 101, "y" : 372 }, "to" : { "x" : 134, "y" : 400 } } ], "endShape" : { "a" : { "x" : 126, "y" : 399 }, "b" : { "x" : 134, "y" : 400 }, "c" : { "x" : 131, "y" : 392 }, "type" : "ARROW", "centre" : { "x" : 131, "y" : 392 } }, "reactionShape" : { "c" : { "x" : 101, "y" : 372 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 101, "y" : 372 } }, "inputs" : [ { "id" : 34051, "points" : [ { "x" : 131, "y" : 334 } ] }, { "id" : 34052, "points" : [ { "x" : 70, "y" : 331 } ] } ], "outputs" : [ { "id" : 34053 } ] }, { "id" : 34084, "reactomeId" : 10199330, "displayName" : "SHC1 in the RET complex is phosphorylated", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 2238, "y" : 315 }, "minX" : 2232, "maxX" : 2246, "minY" : 268, "maxY" : 357, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 2246, "y" : 268 }, "to" : { "x" : 2238, "y" : 315 } }, { "from" : { "x" : 2238, "y" : 315 }, "to" : { "x" : 2244, "y" : 357 } } ], "endShape" : { "a" : { "x" : 2239, "y" : 351 }, "b" : { "x" : 2244, "y" : 357 }, "c" : { "x" : 2247, "y" : 350 }, "type" : "ARROW", "centre" : { "x" : 2247, "y" : 350 } }, "reactionShape" : { "a" : { "x" : 2232, "y" : 309 }, "b" : { "x" : 2244, "y" : 321 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 2238, "y" : 315 } }, "inputs" : [ { "id" : 34083 } ], "outputs" : [ { "id" : 34085 } ] }, { "id" : 34117, "reactomeId" : 10202007, "displayName" : "RET binds GFRA1,GFRA2", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 244, "y" : 119 }, "minX" : 228, "maxX" : 250, "minY" : 96, "maxY" : 125, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 245, "y" : 96 }, "to" : { "x" : 244, "y" : 119 } }, { "from" : { "x" : 244, "y" : 119 }, "to" : { "x" : 228, "y" : 119 } } ], "endShape" : { "a" : { "x" : 235, "y" : 115 }, "b" : { "x" : 228, "y" : 119 }, "c" : { "x" : 235, "y" : 123 }, "type" : "ARROW", "centre" : { "x" : 235, "y" : 123 } }, "reactionShape" : { "c" : { "x" : 244, "y" : 119 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 244, "y" : 119 } }, "inputs" : [ { "id" : 34118, "points" : [ { "x" : 263, "y" : 82 } ] }, { "id" : 34060, "points" : [ { "x" : 187, "y" : 76 } ] } ], "outputs" : [ { "id" : 34048 } ] }, { "id" : 34086, "reactomeId" : 10198973, "displayName" : "2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 binds GRB2-1:SOS1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 2205, "y" : 514 }, "minX" : 2199, "maxX" : 2225, "minY" : 481, "maxY" : 554, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 2205, "y" : 481 }, "to" : { "x" : 2205, "y" : 514 } }, { "from" : { "x" : 2205, "y" : 514 }, "to" : { "x" : 2225, "y" : 554 } } ], "endShape" : { "a" : { "x" : 2218, "y" : 550 }, "b" : { "x" : 2225, "y" : 554 }, "c" : { "x" : 2225, "y" : 546 }, "type" : "ARROW", "centre" : { "x" : 2225, "y" : 546 } }, "reactionShape" : { "c" : { "x" : 2205, "y" : 514 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 2205, "y" : 514 } }, "inputs" : [ { "id" : 34087, "points" : [ { "x" : 1953, "y" : 496 } ] }, { "id" : 34085, "points" : [ { "x" : 2231, "y" : 433 } ] } ], "outputs" : [ { "id" : 34088 } ] }, { "id" : 34054, "reactomeId" : 10199042, "displayName" : "PSPN binds RET:GFRA4", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 102, "y" : 579 }, "minX" : 96, "maxX" : 130, "minY" : 554, "maxY" : 598, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 103, "y" : 554 }, "to" : { "x" : 102, "y" : 579 } }, { "from" : { "x" : 102, "y" : 579 }, "to" : { "x" : 130, "y" : 598 } } ], "endShape" : { "a" : { "x" : 122, "y" : 597 }, "b" : { "x" : 130, "y" : 598 }, "c" : { "x" : 127, "y" : 591 }, "type" : "ARROW", "centre" : { "x" : 127, "y" : 591 } }, "reactionShape" : { "c" : { "x" : 102, "y" : 579 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 102, "y" : 579 } }, "inputs" : [ { "id" : 34055, "points" : [ { "x" : 141, "y" : 533 } ] }, { "id" : 34056, "points" : [ { "x" : 77, "y" : 532 } ] } ], "outputs" : [ { "id" : 34057 } ] }, { "id" : 34119, "reactomeId" : 10202009, "displayName" : "RET binds GFRA4", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 315, "y" : 368 }, "minX" : 170, "maxX" : 321, "minY" : 130, "maxY" : 505, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 313, "y" : 130 }, "to" : { "x" : 315, "y" : 368 } }, { "from" : { "x" : 315, "y" : 368 }, "to" : { "x" : 170, "y" : 505 } } ], "endShape" : { "a" : { "x" : 172, "y" : 497 }, "b" : { "x" : 170, "y" : 505 }, "c" : { "x" : 178, "y" : 503 }, "type" : "ARROW", "centre" : { "x" : 178, "y" : 503 } }, "reactionShape" : { "c" : { "x" : 315, "y" : 368 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 315, "y" : 368 } }, "inputs" : [ { "id" : 34060, "points" : [ { "x" : 187, "y" : 78 } ] }, { "id" : 34120, "points" : [ { "x" : 458, "y" : 74 } ] } ], "outputs" : [ { "id" : 34055 } ] }, { "id" : 34089, "reactomeId" : 10199322, "displayName" : "2x p-5Y-RET:GDNF:GFRA complexes bind GRB2-1:SOS1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1843, "y" : 676 }, "minX" : 1837, "maxX" : 2180, "minY" : 566, "maxY" : 682, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1841, "y" : 566 }, "to" : { "x" : 1843, "y" : 676 } }, { "from" : { "x" : 1843, "y" : 676 }, "to" : { "x" : 2180, "y" : 676 } } ], "endShape" : { "a" : { "x" : 2173, "y" : 680 }, "b" : { "x" : 2180, "y" : 676 }, "c" : { "x" : 2173, "y" : 672 }, "type" : "ARROW", "centre" : { "x" : 2173, "y" : 672 } }, "reactionShape" : { "c" : { "x" : 1843, "y" : 676 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1843, "y" : 676 } }, "inputs" : [ { "id" : 34087, "points" : [ { "x" : 1892, "y" : 513 } ] }, { "id" : 34067, "points" : [ { "x" : 934, "y" : 89 }, { "x" : 947, "y" : 496 } ] } ], "outputs" : [ { "id" : 34090 } ] }, { "id" : 34058, "reactomeId" : 10198983, "displayName" : "RET binds GFRA1,GFRA3", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 276, "y" : 227 }, "minX" : 189, "maxX" : 282, "minY" : 97, "maxY" : 289, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 276, "y" : 97 }, "to" : { "x" : 276, "y" : 227 } }, { "from" : { "x" : 276, "y" : 227 }, "to" : { "x" : 189, "y" : 289 } } ], "endShape" : { "a" : { "x" : 192, "y" : 282 }, "b" : { "x" : 189, "y" : 289 }, "c" : { "x" : 197, "y" : 288 }, "type" : "ARROW", "centre" : { "x" : 197, "y" : 288 } }, "reactionShape" : { "c" : { "x" : 276, "y" : 227 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 276, "y" : 227 } }, "inputs" : [ { "id" : 34059, "points" : [ { "x" : 347, "y" : 81 } ] }, { "id" : 34060, "points" : [ { "x" : 187, "y" : 74 } ] } ], "outputs" : [ { "id" : 34051 } ] }, { "id" : 34091, "reactomeId" : 10199038, "displayName" : "p-5Y-RET complexes bind GRB2", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 603, "y" : 658 }, "minX" : 553, "maxX" : 627, "minY" : 652, "maxY" : 680, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 553, "y" : 658 }, "to" : { "x" : 603, "y" : 658 } }, { "from" : { "x" : 603, "y" : 658 }, "to" : { "x" : 627, "y" : 680 } } ], "endShape" : { "a" : { "x" : 619, "y" : 678 }, "b" : { "x" : 627, "y" : 680 }, "c" : { "x" : 625, "y" : 672 }, "type" : "ARROW", "centre" : { "x" : 625, "y" : 672 } }, "reactionShape" : { "a" : { "x" : 597, "y" : 652 }, "b" : { "x" : 609, "y" : 664 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 603, "y" : 658 } }, "inputs" : [ { "id" : 34092, "points" : [ { "x" : 525, "y" : 621 } ] }, { "id" : 34093, "points" : [ { "x" : 516, "y" : 689 } ] } ], "outputs" : [ { "id" : 34094 } ] }, { "id" : 34061, "reactomeId" : 10199009, "displayName" : "RET dimerizes", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 676, "y" : 21 }, "minX" : 643, "maxX" : 713, "minY" : 15, "maxY" : 47, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 643, "y" : 36 }, "to" : { "x" : 676, "y" : 21 } }, { "from" : { "x" : 676, "y" : 21 }, "to" : { "x" : 713, "y" : 47 } } ], "endShape" : { "a" : { "x" : 705, "y" : 46 }, "b" : { "x" : 713, "y" : 47 }, "c" : { "x" : 710, "y" : 40 }, "type" : "ARROW", "centre" : { "x" : 710, "y" : 40 } }, "reactionShape" : { "c" : { "x" : 676, "y" : 21 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 676, "y" : 21 } }, "inputs" : [ { "id" : 34062, "stoichiometry" : 2 } ], "outputs" : [ { "id" : 34063 } ] }, { "id" : 34095, "reactomeId" : 10199320, "displayName" : "p-5Y-RET-GRB2-containing complexes bind GAB1,GAB2", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 734, "y" : 651 }, "minX" : 707, "maxX" : 780, "minY" : 645, "maxY" : 682, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 707, "y" : 651 }, "to" : { "x" : 734, "y" : 651 } }, { "from" : { "x" : 734, "y" : 651 }, "to" : { "x" : 780, "y" : 682 } } ], "endShape" : { "a" : { "x" : 772, "y" : 681 }, "b" : { "x" : 780, "y" : 682 }, "c" : { "x" : 776, "y" : 675 }, "type" : "ARROW", "centre" : { "x" : 776, "y" : 675 } }, "reactionShape" : { "a" : { "x" : 728, "y" : 645 }, "b" : { "x" : 740, "y" : 657 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 734, "y" : 651 } }, "inputs" : [ { "id" : 34096, "points" : [ { "x" : 669, "y" : 629 } ] }, { "id" : 34094, "points" : [ { "x" : 680, "y" : 680 } ] } ], "outputs" : [ { "id" : 34097 } ] }, { "id" : 34064, "reactomeId" : 10199034, "displayName" : "RET tyrosine phosphorylation", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 829, "y" : 97 }, "minX" : 807, "maxX" : 854, "minY" : 91, "maxY" : 103, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 807, "y" : 96 }, "to" : { "x" : 829, "y" : 97 } }, { "from" : { "x" : 829, "y" : 97 }, "to" : { "x" : 854, "y" : 96 } } ], "reactionShape" : { "a" : { "x" : 823, "y" : 91 }, "b" : { "x" : 835, "y" : 103 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 829, "y" : 97 } }, "inputs" : [ { "id" : 34063, "points" : [ { "x" : 782, "y" : 89 } ] }, { "id" : 34065, "points" : [ { "x" : 785, "y" : 119 } ], "stoichiometry" : 30 } ], "outputs" : [ { "id" : 34066, "points" : [ { "x" : 872, "y" : 120 } ], "stoichiometry" : 30 }, { "id" : 34067, "points" : [ { "x" : 878, "y" : 84 } ] } ], "catalysts" : [ { "id" : 34063, "points" : [ { "x" : 799, "y" : 59 }, { "x" : 829, "y" : 55 } ] } ] }, { "id" : 34098, "reactomeId" : 10199029, "displayName" : "GAB in p-5Y-RET:GDNF:GFRA complexes is phosphorylated", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 896, "y" : 653 }, "minX" : 875, "maxX" : 919, "minY" : 647, "maxY" : 659, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 875, "y" : 654 }, "to" : { "x" : 896, "y" : 653 } }, { "from" : { "x" : 896, "y" : 653 }, "to" : { "x" : 919, "y" : 654 } } ], "reactionShape" : { "a" : { "x" : 890, "y" : 647 }, "b" : { "x" : 902, "y" : 659 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 896, "y" : 653 } }, "inputs" : [ { "id" : 34097, "points" : [ { "x" : 849, "y" : 682 } ] }, { "id" : 34099, "points" : [ { "x" : 840, "y" : 625 } ], "stoichiometry" : 5 } ], "outputs" : [ { "id" : 34100, "points" : [ { "x" : 942, "y" : 673 } ] }, { "id" : 34101, "points" : [ { "x" : 966, "y" : 619 } ], "stoichiometry" : 5 } ] }, { "id" : 34068, "reactomeId" : 10199328, "displayName" : "PKA phosphorylates RET:GDNF:GFRA dimer", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 314, "y" : 618 }, "minX" : 275, "maxX" : 320, "minY" : 582, "maxY" : 669, "reactionType" : "transition", "segments" : [ { "from" : { "x" : 314, "y" : 582 }, "to" : { "x" : 314, "y" : 618 } }, { "from" : { "x" : 314, "y" : 618 }, "to" : { "x" : 275, "y" : 669 } } ], "endShape" : { "a" : { "x" : 276, "y" : 661 }, "b" : { "x" : 275, "y" : 669 }, "c" : { "x" : 282, "y" : 666 }, "type" : "ARROW", "centre" : { "x" : 282, "y" : 666 } }, "reactionShape" : { "a" : { "x" : 308, "y" : 612 }, "b" : { "x" : 320, "y" : 624 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 314, "y" : 618 } }, "inputs" : [ { "id" : 34063, "points" : [ { "x" : 722, "y" : 89 } ] }, { "id" : 34069, "points" : [ { "x" : 298, "y" : 569 } ], "stoichiometry" : 6 } ], "outputs" : [ { "id" : 34070 } ], "catalysts" : [ { "id" : 34071, "points" : [ { "x" : 351, "y" : 618 } ] } ] }, { "id" : 34102, "reactomeId" : 10199326, "displayName" : "p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K", "schemaClass" : "BlackBoxEvent", "renderableClass" : "Reaction", "position" : { "x" : 1184, "y" : 712 }, "minX" : 1144, "maxX" : 1245, "minY" : 706, "maxY" : 718, "reactionType" : "omitted", "segments" : [ { "from" : { "x" : 1144, "y" : 712 }, "to" : { "x" : 1184, "y" : 712 } }, { "from" : { "x" : 1184, "y" : 712 }, "to" : { "x" : 1245, "y" : 714 } } ], "endShape" : { "a" : { "x" : 1238, "y" : 718 }, "b" : { "x" : 1245, "y" : 714 }, "c" : { "x" : 1238, "y" : 710 }, "type" : "ARROW", "centre" : { "x" : 1238, "y" : 710 } }, "reactionShape" : { "a" : { "x" : 1178, "y" : 706 }, "b" : { "x" : 1190, "y" : 718 }, "s" : "\\\\", "type" : "BOX", "empty" : true, "centre" : { "x" : 1184, "y" : 712 } }, "inputs" : [ { "id" : 34100, "points" : [ { "x" : 1056, "y" : 713 } ] }, { "id" : 34103, "points" : [ { "x" : 1132, "y" : 685 } ] } ], "outputs" : [ { "id" : 34104 } ] }, { "id" : 34072, "reactomeId" : 10199492, "displayName" : "2x p-5Y-RET:GDNF:GFRA complexes bind RET interactors", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1098, "y" : 84 }, "minX" : 1063, "maxX" : 1116, "minY" : 78, "maxY" : 90, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1063, "y" : 85 }, "to" : { "x" : 1098, "y" : 84 } }, { "from" : { "x" : 1098, "y" : 84 }, "to" : { "x" : 1116, "y" : 79 } } ], "endShape" : { "a" : { "x" : 1110, "y" : 85 }, "b" : { "x" : 1116, "y" : 79 }, "c" : { "x" : 1108, "y" : 77 }, "type" : "ARROW", "centre" : { "x" : 1108, "y" : 77 } }, "reactionShape" : { "c" : { "x" : 1098, "y" : 84 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1098, "y" : 84 } }, "inputs" : [ { "id" : 34073, "points" : [ { "x" : 1045, "y" : 107 } ] }, { "id" : 34067, "points" : [ { "x" : 991, "y" : 70 } ] } ], "outputs" : [ { "id" : 34074 } ] }, { "id" : 34105, "reactomeId" : 10199398, "displayName" : "p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1568, "y" : 618 }, "minX" : 1513, "maxX" : 1610, "minY" : 612, "maxY" : 674, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1513, "y" : 617 }, "to" : { "x" : 1568, "y" : 618 } }, { "from" : { "x" : 1568, "y" : 618 }, "to" : { "x" : 1610, "y" : 674 } } ], "endShape" : { "a" : { "x" : 1603, "y" : 671 }, "b" : { "x" : 1610, "y" : 674 }, "c" : { "x" : 1609, "y" : 666 }, "type" : "ARROW", "centre" : { "x" : 1609, "y" : 666 } }, "reactionShape" : { "c" : { "x" : 1568, "y" : 618 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1568, "y" : 618 } }, "inputs" : [ { "id" : 34100, "points" : [ { "x" : 1014, "y" : 673 }, { "x" : 1064, "y" : 615 } ] }, { "id" : 34106, "points" : [ { "x" : 1476, "y" : 596 } ] } ], "outputs" : [ { "id" : 34107 } ] }, { "id" : 34075, "reactomeId" : 10199402, "displayName" : "2x p-5Y-RET:GDNF:GFRA complexes bind FRS2", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1576, "y" : 6 }, "minX" : 1528, "maxX" : 1608, "minY" : 0, "maxY" : 41, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1528, "y" : 6 }, "to" : { "x" : 1576, "y" : 6 } }, { "from" : { "x" : 1576, "y" : 6 }, "to" : { "x" : 1608, "y" : 41 } } ], "endShape" : { "a" : { "x" : 1600, "y" : 39 }, "b" : { "x" : 1608, "y" : 41 }, "c" : { "x" : 1606, "y" : 33 }, "type" : "ARROW", "centre" : { "x" : 1606, "y" : 33 } }, "reactionShape" : { "c" : { "x" : 1576, "y" : 6 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1576, "y" : 6 } }, "inputs" : [ { "id" : 34076, "points" : [ { "x" : 1488, "y" : 55 } ] }, { "id" : 34067, "points" : [ { "x" : 975, "y" : 34 }, { "x" : 1022, "y" : 9 } ] } ], "outputs" : [ { "id" : 34077 } ] }, { "id" : 34108, "reactomeId" : 10198989, "displayName" : "2x p-5Y-RET:GDNF:GFRA complexes bind GRB7,10", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1448, "y" : 240 }, "minX" : 1180, "maxX" : 1739, "minY" : 98, "maxY" : 246, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1180, "y" : 242 }, "to" : { "x" : 1448, "y" : 240 } }, { "from" : { "x" : 1448, "y" : 240 }, "to" : { "x" : 1739, "y" : 98 } } ], "endShape" : { "a" : { "x" : 1735, "y" : 105 }, "b" : { "x" : 1739, "y" : 98 }, "c" : { "x" : 1731, "y" : 97 }, "type" : "ARROW", "centre" : { "x" : 1731, "y" : 97 } }, "reactionShape" : { "c" : { "x" : 1448, "y" : 240 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1448, "y" : 240 } }, "inputs" : [ { "id" : 34109, "points" : [ { "x" : 1161, "y" : 264 } ] }, { "id" : 34067, "points" : [ { "x" : 939, "y" : 89 }, { "x" : 978, "y" : 242 } ] } ], "outputs" : [ { "id" : 34110 } ] }, { "id" : 34078, "reactomeId" : 10199420, "displayName" : "2x p-5Y-RET:GDNF:GFRA complexes binds DOK1,DOK2,DOK4,DOK5,DOK6", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1201, "y" : 167 }, "minX" : 1123, "maxX" : 1300, "minY" : 103, "maxY" : 173, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1123, "y" : 168 }, "to" : { "x" : 1201, "y" : 167 } }, { "from" : { "x" : 1201, "y" : 167 }, "to" : { "x" : 1300, "y" : 103 } } ], "endShape" : { "a" : { "x" : 1296, "y" : 110 }, "b" : { "x" : 1300, "y" : 103 }, "c" : { "x" : 1292, "y" : 103 }, "type" : "ARROW", "centre" : { "x" : 1292, "y" : 103 } }, "reactionShape" : { "c" : { "x" : 1201, "y" : 167 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1201, "y" : 167 } }, "inputs" : [ { "id" : 34067, "points" : [ { "x" : 945, "y" : 89 }, { "x" : 985, "y" : 167 } ] }, { "id" : 34079, "points" : [ { "x" : 1111, "y" : 178 } ] } ], "outputs" : [ { "id" : 34080 } ] }, { "id" : 34046, "reactomeId" : 10199031, "displayName" : "GDNF,NRTN bind RET:GFRA1,GFRA2", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 103, "y" : 181 }, "minX" : 97, "maxX" : 125, "minY" : 158, "maxY" : 194, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 104, "y" : 158 }, "to" : { "x" : 103, "y" : 181 } }, { "from" : { "x" : 103, "y" : 181 }, "to" : { "x" : 125, "y" : 194 } } ], "endShape" : { "a" : { "x" : 117, "y" : 194 }, "b" : { "x" : 125, "y" : 194 }, "c" : { "x" : 121, "y" : 187 }, "type" : "ARROW", "centre" : { "x" : 121, "y" : 187 } }, "reactionShape" : { "c" : { "x" : 103, "y" : 181 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 103, "y" : 181 } }, "inputs" : [ { "id" : 34047, "points" : [ { "x" : 59, "y" : 135 } ] }, { "id" : 34048, "points" : [ { "x" : 147, "y" : 133 } ] } ], "outputs" : [ { "id" : 34049 } ] }, { "id" : 34111, "reactomeId" : 10198993, "displayName" : "2x p-5Y-RET:GDNF:GFRA complexes bind PLCgamma1", "schemaClass" : "Reaction", "renderableClass" : "Reaction", "position" : { "x" : 1496, "y" : 315 }, "minX" : 1248, "maxX" : 1942, "minY" : 102, "maxY" : 321, "reactionType" : "binding", "segments" : [ { "from" : { "x" : 1248, "y" : 318 }, "to" : { "x" : 1496, "y" : 315 } }, { "from" : { "x" : 1496, "y" : 315 }, "to" : { "x" : 1942, "y" : 102 } } ], "endShape" : { "a" : { "x" : 1937, "y" : 109 }, "b" : { "x" : 1942, "y" : 102 }, "c" : { "x" : 1934, "y" : 101 }, "type" : "ARROW", "centre" : { "x" : 1934, "y" : 101 } }, "reactionShape" : { "c" : { "x" : 1496, "y" : 315 }, "r" : 5, "type" : "CIRCLE", "centre" : { "x" : 1496, "y" : 315 } }, "inputs" : [ { "id" : 34112, "points" : [ { "x" : 1220, "y" : 346 } ] }, { "id" : 34067, "points" : [ { "x" : 938, "y" : 89 }, { "x" : 986, "y" : 318 } ] } ], "outputs" : [ { "id" : 34113 } ] } ], "compartments" : [ { "id" : 34121, "reactomeId" : 70101, "displayName" : "cytosol", "schemaClass" : "Compartment", "renderableClass" : "Compartment", "position" : { "x" : 1208, "y" : 394 }, "minX" : 156, "maxX" : 2260, "minY" : 61, "maxY" : 728, "prop" : { "x" : 156, "y" : 61, "width" : 2104, "height" : 667 }, "textPosition" : { "x" : 470, "y" : 477 }, "insets" : { "x" : 166, "y" : 71, "width" : 2084, "height" : 647 }, "bgColor" : { "r" : 250, "g" : 240, "b" : 240 }, "componentIds" : [ 34048, 34049, 34053, 34124, 34125, 34126, 34062, 34063, 34064, 34065, 34066, 34067, 34070, 34071, 34068, 34069, 34072, 34073, 34074, 34076, 34077, 34078, 34079, 34080, 34083, 34081, 34082, 34085, 34086, 34087, 34088, 34089, 34090, 34123, 34127, 34128, 34091, 34092, 34093, 34129, 34094, 34095, 34097, 34096, 34098, 34100, 34099, 34101, 34104, 34102, 34103, 34105, 34106, 34107, 34108, 34109, 34110, 34084, 34111, 34112, 34113, 34114, 34115, 34116, 34058, 34118, 34117, 34059, 34051, 34055, 34057, 34060, 34120, 34119 ] } ], "notes" : [ ], "links" : [ { "id" : 34128, "renderableClass" : "Interaction", "position" : { "x" : 2132, "y" : 637 }, "minX" : 2085, "maxX" : 2180, "minY" : 621, "maxY" : 654, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 2180, "y" : 654 }, "to" : { "x" : 2085, "y" : 621 } } ], "endShape" : { "a" : { "x" : 2093, "y" : 619 }, "b" : { "x" : 2085, "y" : 621 }, "c" : { "x" : 2090, "y" : 627 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 2090, "y" : 627 } }, "reactionShape" : { "a" : { "x" : 2126, "y" : 631 }, "b" : { "x" : 2138, "y" : 643 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2132, "y" : 637 } }, "inputs" : [ { "id" : 34090 } ], "outputs" : [ { "id" : 34123 } ] }, { "id" : 34129, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 648, "y" : 504 }, "minX" : 463, "maxX" : 927, "minY" : 89, "maxY" : 689, "segments" : [ { "from" : { "x" : 927, "y" : 89 }, "to" : { "x" : 834, "y" : 446 } }, { "from" : { "x" : 834, "y" : 446 }, "to" : { "x" : 463, "y" : 563 } }, { "from" : { "x" : 463, "y" : 563 }, "to" : { "x" : 487, "y" : 689 } } ], "reactionShape" : { "a" : { "x" : 642, "y" : 498 }, "b" : { "x" : 654, "y" : 510 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 648, "y" : 504 } }, "inputs" : [ { "id" : 34067 } ], "outputs" : [ { "id" : 34093 } ] }, { "id" : 34130, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 2345, "y" : 806 }, "minX" : 535, "maxX" : 2359, "minY" : 394, "maxY" : 812, "segments" : [ { "from" : { "x" : 2319, "y" : 394 }, "to" : { "x" : 2359, "y" : 394 } }, { "from" : { "x" : 2359, "y" : 394 }, "to" : { "x" : 2345, "y" : 806 } }, { "from" : { "x" : 2345, "y" : 806 }, "to" : { "x" : 652, "y" : 812 } }, { "from" : { "x" : 652, "y" : 812 }, "to" : { "x" : 535, "y" : 751 } } ], "reactionShape" : { "a" : { "x" : 2339, "y" : 800 }, "b" : { "x" : 2351, "y" : 812 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2345, "y" : 806 } }, "inputs" : [ { "id" : 34085 } ], "outputs" : [ { "id" : 34093 } ] }, { "id" : 34131, "renderableClass" : "EntitySetAndEntitySetLink", "position" : { "x" : 330, "y" : 62 }, "minX" : 324, "maxX" : 336, "minY" : 56, "maxY" : 68, "segments" : [ { "from" : { "x" : 328, "y" : 62 }, "to" : { "x" : 332, "y" : 62 } } ], "reactionShape" : { "a" : { "x" : 324, "y" : 56 }, "b" : { "x" : 336, "y" : 68 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 330, "y" : 62 } }, "inputs" : [ { "id" : 34118 } ], "outputs" : [ { "id" : 34059 } ] }, { "id" : 34124, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 379, "y" : 144 }, "minX" : 208, "maxX" : 551, "minY" : 82, "maxY" : 207, "segments" : [ { "from" : { "x" : 208, "y" : 207 }, "to" : { "x" : 551, "y" : 82 } } ], "reactionShape" : { "a" : { "x" : 373, "y" : 138 }, "b" : { "x" : 385, "y" : 150 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 379, "y" : 144 } }, "inputs" : [ { "id" : 34049 } ], "outputs" : [ { "id" : 34062 } ] }, { "id" : 34125, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 375, "y" : 247 }, "minX" : 175, "maxX" : 576, "minY" : 95, "maxY" : 400, "segments" : [ { "from" : { "x" : 175, "y" : 400 }, "to" : { "x" : 576, "y" : 95 } } ], "reactionShape" : { "a" : { "x" : 369, "y" : 241 }, "b" : { "x" : 381, "y" : 253 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 375, "y" : 247 } }, "inputs" : [ { "id" : 34053 } ], "outputs" : [ { "id" : 34062 } ] }, { "id" : 34126, "renderableClass" : "EntitySetAndMemberLink", "position" : { "x" : 377, "y" : 346 }, "minX" : 167, "maxX" : 587, "minY" : 95, "maxY" : 598, "segments" : [ { "from" : { "x" : 167, "y" : 598 }, "to" : { "x" : 587, "y" : 95 } } ], "reactionShape" : { "a" : { "x" : 371, "y" : 340 }, "b" : { "x" : 383, "y" : 352 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 377, "y" : 346 } }, "inputs" : [ { "id" : 34057 } ], "outputs" : [ { "id" : 34062 } ] }, { "id" : 34127, "renderableClass" : "Interaction", "position" : { "x" : 2125, "y" : 594 }, "minX" : 2085, "maxX" : 2166, "minY" : 588, "maxY" : 600, "interactionType" : "Activate", "segments" : [ { "from" : { "x" : 2166, "y" : 592 }, "to" : { "x" : 2085, "y" : 596 } } ], "endShape" : { "a" : { "x" : 2092, "y" : 592 }, "b" : { "x" : 2085, "y" : 596 }, "c" : { "x" : 2092, "y" : 600 }, "type" : "ARROW", "empty" : true, "centre" : { "x" : 2092, "y" : 600 } }, "reactionShape" : { "a" : { "x" : 2119, "y" : 588 }, "b" : { "x" : 2131, "y" : 600 }, "type" : "BOX", "empty" : true, "centre" : { "x" : 2125, "y" : 594 } }, "inputs" : [ { "id" : 34088 } ], "outputs" : [ { "id" : 34123 } ] } ], "shadows" : [ ], "minX" : 0, "maxX" : 2359, "minY" : 0, "maxY" : 812, "disease" : false }